All-trans-retinol 13,14-reductase
AltitudeomicsDB
Protein Official symbol |
RETSAT |
Aliases |
RETSAT PPSIG UNQ439/PRO872 |
Chromosomal Location |
2 |
Length |
610 |
Uniprot ID |
Q6NUM9 |
EC number |
1.3.99.23 |
Protein family Information(Pfam) |
None |
PDB id |
None |
InterPro ID |
IPR036188; |
dbSNP |
rs4832169 rs4832168 rs13384912 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
ADH1B |
ADH1A |
0.982 |
RDH12 |
LRAT |
0.979 |
RDH10 |
CYP26A1 |
0.973 |
LRAT |
CYP26A1 |
0.97 |
LRAT |
RDH10 |
0.969 |
RDH11 |
LRAT |
0.966 |
DHRS3 |
CYP26A1 |
0.962 |
DHRS9 |
LRAT |
0.953 |
RDH16 |
CYP26A1 |
0.951 |
RDH8 |
LRAT |
0.95 |
RDH16 |
LRAT |
0.949 |
ADH7 |
LRAT |
0.947 |
RDH12 |
RETSAT |
0.946 |
DHRS9 |
CYP26A1 |
0.946 |
DHRS3 |
LRAT |
0.945 |
ADH7 |
CYP26A1 |
0.942 |
RDH11 |
RETSAT |
0.938 |
LRAT |
RETSAT |
0.937 |
RETSAT |
CYP26A1 |
0.935 |
LRAT |
ADH1A |
0.935 |
CYP26A1 |
ADH1A |
0.935 |
DHRS3 |
RETSAT |
0.934 |
ADH5 |
CYP26A1 |
0.933 |
RDH12 |
CYP26A1 |
0.933 |
ADH4 |
CYP26A1 |
0.932 |
SDR16C5 |
RETSAT |
0.932 |
RDH11 |
CYP26A1 |
0.93 |
DHRS4 |
RETSAT |
0.929 |
RDH8 |
RETSAT |
0.929 |
RETSAT |
RDH10 |
0.927 |
ADH1C |
CYP26A1 |
0.924 |
ADH6 |
CYP26A1 |
0.924 |
RDH8 |
CYP26A1 |
0.923 |
ADH1C |
LRAT |
0.923 |
RETSAT |
ADH1A |
0.922 |
LRAT |
SDR16C5 |
0.921 |
DGAT1 |
DHRS4 |
0.921 |
DGAT1 |
CYP26A1 |
0.921 |
HSD17B6 |
RETSAT |
0.92 |
PNPLA4 |
DHRS4 |
0.919 |
ADH5 |
RETSAT |
0.919 |
DHRS4 |
CYP26A1 |
0.918 |
DGAT1 |
HSD17B6 |
0.918 |
ADH1B |
CYP26A1 |
0.918 |
LRAT |
ADH1B |
0.918 |
DGAT1 |
AWAT2 |
0.917 |
DGAT1 |
RDH10 |
0.917 |
DGAT1 |
DHRS9 |
0.917 |
HSD17B6 |
LRAT |
0.917 |
LRAT |
ADH5 |
0.916 |
DGAT1 |
RETSAT |
0.916 |
ADH1C |
ADH1A |
0.916 |
ADH1C |
ADH1B |
0.915 |
DGAT1 |
DHRS3 |
0.915 |
DHRS9 |
RETSAT |
0.914 |
ADH1C |
RETSAT |
0.913 |
LRAT |
ADH4 |
0.911 |
LRAT |
DHRS4 |
0.91 |
ADH7 |
PNPLA4 |
0.909 |
DHRS9 |
DHRS4 |
0.907 |
DGAT1 |
SDR16C5 |
0.906 |
RETSAT |
ADH4 |
0.906 |
ADH6 |
LRAT |
0.906 |
DGAT1 |
RDH11 |
0.905 |
AWAT2 |
DHRS4 |
0.905 |
AWAT2 |
RDH10 |
0.904 |
AWAT2 |
RDH11 |
0.904 |
AWAT2 |
SDR16C5 |
0.904 |
RDH16 |
RETSAT |
0.904 |
DHRS3 |
AWAT2 |
0.904 |
ADH1B |
RETSAT |
0.903 |
AWAT2 |
RETSAT |
0.903 |
ADH7 |
RETSAT |
0.902 |
ADH6 |
RETSAT |
0.902 |
AWAT2 |
CYP26A1 |
0.901 |
PNPLA4 |
RDH10 |
0.901 |
PNPLA4 |
SDR16C5 |
0.901 |
HSD17B6 |
PNPLA4 |
0.901 |
DHRS3 |
PNPLA4 |
0.901 |
PNPLA4 |
RETSAT |
0.9 |
PNPLA4 |
CYP26A1 |
0.9 |
HSD17B6 |
AWAT2 |
0.9 |
DHRS9 |
PNPLA4 |
0.9 |
PNPLA4 |
ADH5 |
0.9 |
PNPLA4 |
ADH4 |
0.9 |
RDH12 |
PNPLA4 |
0.9 |
PNPLA4 |
ADH1B |
0.9 |
PNPLA4 |
ADH1A |
0.9 |
RDH11 |
PNPLA4 |
0.9 |
RDH8 |
PNPLA4 |
0.9 |
AWAT2 |
DHRS9 |
0.9 |
RDH16 |
PNPLA4 |
0.9 |
ADH6 |
PNPLA4 |
0.9 |
ADH1C |
PNPLA4 |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
125 (ADH1B) |
145226 (RDH12) |
157506 (RDH10) |
9227 (LRAT) |
51109 (RDH11) |
9249 (DHRS3) |
10170 (DHRS9) |
8608 (RDH16) |
50700 (RDH8) |
131 (ADH7) |
54884 (RETSAT) |
1592 (CYP26A1) |
128 (ADH5) |
127 (ADH4) |
195814 (SDR16C5) |
10901 (DHRS4) |
126 (ADH1C) |
130 (ADH6) |
8694 (DGAT1) |
8630 (HSD17B6) |
8228 (PNPLA4) |
158835 (AWAT2) |
125 (ADH1B)
|
1.00
|
0.48
|
0.46
|
0.18
|
0.54
|
0.39
|
0.54
|
0.41
|
0.63
|
0.52
|
0.39
|
0.28
|
0.57
|
0.57
|
0.35
|
0.48
|
0.72
|
0.97
|
0.25
|
0.37
|
0.15
|
0.13
|
145226 (RDH12)
|
0.48
|
1.00
|
0.83
|
0.22
|
0.98
|
0.72
|
0.63
|
0.65
|
1.00
|
0.59
|
0.47
|
0.39
|
0.45
|
0.49
|
0.74
|
0.77
|
0.68
|
0.55
|
0.49
|
0.47
|
0.18
|
0.16
|
157506 (RDH10)
|
0.46
|
0.83
|
1.00
|
0.23
|
0.84
|
0.72
|
0.70
|
0.69
|
1.00
|
0.50
|
0.52
|
0.24
|
0.38
|
0.44
|
0.49
|
0.68
|
0.79
|
0.55
|
0.22
|
0.47
|
0.18
|
0.16
|
9227 (LRAT)
|
0.18
|
0.22
|
0.23
|
1.00
|
0.25
|
0.22
|
0.30
|
0.24
|
0.28
|
0.21
|
0.38
|
0.21
|
0.21
|
0.22
|
0.21
|
0.26
|
0.24
|
0.21
|
0.69
|
0.46
|
0.23
|
0.70
|
51109 (RDH11)
|
0.54
|
0.98
|
0.84
|
0.25
|
1.00
|
0.74
|
0.69
|
0.68
|
1.00
|
0.64
|
0.53
|
0.41
|
0.52
|
0.55
|
0.75
|
0.83
|
0.74
|
0.63
|
0.48
|
0.53
|
0.20
|
0.18
|
9249 (DHRS3)
|
0.39
|
0.72
|
0.72
|
0.22
|
0.74
|
1.00
|
0.57
|
0.79
|
1.00
|
0.52
|
0.43
|
0.37
|
0.57
|
0.54
|
0.51
|
0.62
|
0.60
|
0.46
|
0.29
|
0.62
|
0.17
|
0.16
|
10170 (DHRS9)
|
0.54
|
0.63
|
0.70
|
0.30
|
0.69
|
0.57
|
1.00
|
0.65
|
1.00
|
0.58
|
0.53
|
0.27
|
0.43
|
0.52
|
0.52
|
0.57
|
0.82
|
0.66
|
0.29
|
0.55
|
0.23
|
0.21
|
8608 (RDH16)
|
0.41
|
0.65
|
0.69
|
0.24
|
0.68
|
0.79
|
0.65
|
1.00
|
1.00
|
0.49
|
0.49
|
0.30
|
0.59
|
0.44
|
0.53
|
0.55
|
0.71
|
0.50
|
0.28
|
0.73
|
0.20
|
0.18
|
50700 (RDH8)
|
0.63
|
1.00
|
1.00
|
0.28
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.60
|
0.36
|
0.73
|
1.00
|
1.00
|
0.73
|
1.00
|
0.73
|
0.28
|
0.60
|
0.20
|
0.17
|
131 (ADH7)
|
0.52
|
0.59
|
0.50
|
0.21
|
0.64
|
0.52
|
0.58
|
0.49
|
1.00
|
1.00
|
0.42
|
0.37
|
0.48
|
0.70
|
0.51
|
0.57
|
0.66
|
0.60
|
0.32
|
0.41
|
0.16
|
0.14
|
54884 (RETSAT)
|
0.39
|
0.47
|
0.52
|
0.38
|
0.53
|
0.43
|
0.53
|
0.49
|
0.60
|
0.42
|
1.00
|
0.39
|
0.39
|
0.44
|
0.38
|
0.54
|
0.55
|
0.46
|
0.37
|
0.76
|
0.32
|
0.29
|
1592 (CYP26A1)
|
0.28
|
0.39
|
0.24
|
0.21
|
0.41
|
0.37
|
0.27
|
0.30
|
0.36
|
0.37
|
0.39
|
1.00
|
0.41
|
0.39
|
0.36
|
0.37
|
0.26
|
0.30
|
0.35
|
0.41
|
0.16
|
0.15
|
128 (ADH5)
|
0.57
|
0.45
|
0.38
|
0.21
|
0.52
|
0.57
|
0.43
|
0.59
|
0.73
|
0.48
|
0.39
|
0.41
|
1.00
|
0.58
|
0.38
|
0.48
|
0.44
|
0.61
|
0.29
|
0.57
|
0.16
|
0.15
|
127 (ADH4)
|
0.57
|
0.49
|
0.44
|
0.22
|
0.55
|
0.54
|
0.52
|
0.44
|
1.00
|
0.70
|
0.44
|
0.39
|
0.58
|
1.00
|
0.43
|
0.54
|
0.56
|
0.63
|
0.28
|
0.44
|
0.16
|
0.15
|
195814 (SDR16C5)
|
0.35
|
0.74
|
0.49
|
0.21
|
0.75
|
0.51
|
0.52
|
0.53
|
1.00
|
0.51
|
0.38
|
0.36
|
0.38
|
0.43
|
1.00
|
0.60
|
0.54
|
0.42
|
0.47
|
0.41
|
0.16
|
0.15
|
10901 (DHRS4)
|
0.48
|
0.77
|
0.68
|
0.26
|
0.83
|
0.62
|
0.57
|
0.55
|
0.73
|
0.57
|
0.54
|
0.37
|
0.48
|
0.54
|
0.60
|
1.00
|
0.60
|
0.56
|
0.40
|
0.53
|
0.20
|
0.18
|
126 (ADH1C)
|
0.72
|
0.68
|
0.79
|
0.24
|
0.74
|
0.60
|
0.82
|
0.71
|
1.00
|
0.66
|
0.55
|
0.26
|
0.44
|
0.56
|
0.54
|
0.60
|
1.00
|
0.80
|
0.24
|
0.50
|
0.19
|
0.17
|
130 (ADH6)
|
0.97
|
0.55
|
0.55
|
0.21
|
0.63
|
0.46
|
0.66
|
0.50
|
0.73
|
0.60
|
0.46
|
0.30
|
0.61
|
0.63
|
0.42
|
0.56
|
0.80
|
1.00
|
0.27
|
0.43
|
0.17
|
0.15
|
8694 (DGAT1)
|
0.25
|
0.49
|
0.22
|
0.69
|
0.48
|
0.29
|
0.29
|
0.28
|
0.28
|
0.32
|
0.37
|
0.35
|
0.29
|
0.28
|
0.47
|
0.40
|
0.24
|
0.27
|
1.00
|
0.46
|
0.23
|
0.60
|
8630 (HSD17B6)
|
0.37
|
0.47
|
0.47
|
0.46
|
0.53
|
0.62
|
0.55
|
0.73
|
0.60
|
0.41
|
0.76
|
0.41
|
0.57
|
0.44
|
0.41
|
0.53
|
0.50
|
0.43
|
0.46
|
1.00
|
0.38
|
0.36
|
8228 (PNPLA4)
|
0.15
|
0.18
|
0.18
|
0.23
|
0.20
|
0.17
|
0.23
|
0.20
|
0.20
|
0.16
|
0.32
|
0.16
|
0.16
|
0.16
|
0.16
|
0.20
|
0.19
|
0.17
|
0.23
|
0.38
|
1.00
|
0.17
|
158835 (AWAT2)
|
0.13
|
0.16
|
0.16
|
0.70
|
0.18
|
0.16
|
0.21
|
0.18
|
0.17
|
0.14
|
0.29
|
0.15
|
0.15
|
0.15
|
0.15
|
0.18
|
0.17
|
0.15
|
0.60
|
0.36
|
0.17
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
RETSAT |
Toad |
Heart |
- |
3464 m |
33 day |
downregulated |
-2.342045208 |
RNA-seq |
Tibetan Plateau |
Asiatic toad |
1 |
Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - |
28673260 |
Association with TF
TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
TAF1 |
6872 |
RETSAT |
54884 |
proximal_filtered |
22955619 |
TRANSFAC |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
54884 |
GO:0042572 |
retinol metabolic process |
GOTERM_BP_DIRECT |
54884 |
GO:0005789 |
endoplasmic reticulum membrane |
GOTERM_CC_DIRECT |
54884 |
GO:0005640 |
nuclear outer membrane |
GOTERM_CC_DIRECT |
54884 |
GO:0031965 |
nuclear membrane |
GOTERM_CC_DIRECT |
54884 |
GO:0016491 |
oxidoreductase activity |
GOTERM_MF_DIRECT |
54884 |
GO:0051786 |
4 iron |
GOTERM_MF_DIRECT |
54884 |
GO:0016020 |
membrane |
GOTERM_CC_DIRECT |
54884 |
GO:0055114 |
oxidation-reduction process |
GOTERM_BP_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
54884 |
hsa00830 |
Retinol metabolism |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
RETSAT |
54884 |
SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 |
C0796154 |
Disease or Syndrome |
0.3 |
0.928 |
0.31 |
disease |
Association with Drug
Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |