Alcohol dehydrogenase 1C (class I), gamma polypeptide

AltitudeomicsDB
Protein Official symbol ADH1C
Aliases ADH1C ADH3
Chromosomal Location 4
Length 375
Uniprot ID P00326
EC number 1.1.1.1
Protein family Information(Pfam) PF08240;PF00107;
PDB id 1DDA;1HT0;1U3W;
InterPro ID IPR013149;IPR013154;IPR002328;IPR011032;IPR036291;IPR020843;
dbSNP rs35385902 rs34195308 rs1693482 rs698 rs35719513

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ADH1B ALDH2 0.993
ADH1B ADH1A 0.982
CYP2E1 ADH1B 0.9740000000000001
CYP2E1 ADH1C 0.9740000000000001
ADH1C ADH1B 0.973
CYP2E1 ALDH2 0.973
LRAT CYP26A1 0.97
CYP2E1 ADH1A 0.9620000000000001
ADH1C ALDH2 0.946
AOX1 ADH1B 0.938
LRAT RETSAT 0.937
RETSAT CYP26A1 0.935
LRAT ADH1A 0.935
CYP26A1 ADH1A 0.935
AOX1 ADH1A 0.929
ADH1C CYP26A1 0.924
ADH1C LRAT 0.9229999999999999
AOX1 BCO1 0.9229999999999999
RETSAT ADH1A 0.922
ADH1C AOX1 0.9179999999999999
LRAT ADH1B 0.9179999999999999
ADH1B CYP26A1 0.9179999999999999
ADH1C ADH1A 0.9159999999999999
ADH1C RETSAT 0.9129999999999999
AOX1 CYP26A1 0.912
ADH1C BCO1 0.9109999999999999
ALDH2 ADH1A 0.909
BCO1 ADH1A 0.905
ADH1B BCO1 0.903
ADH1B RETSAT 0.903
PNPLA4 RETSAT 0.9
PNPLA4 CYP26A1 0.9
ADH1C PNPLA4 0.9
PNPLA4 ADH1A 0.9
PNPLA4 ADH1B 0.9
Gene Ontology Semantic Similarity
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# 125 (ADH1B) 1571 (CYP2E1) 126 (ADH1C) 9227 (LRAT) 316 (AOX1) 54884 (RETSAT) 1592 (CYP26A1) 217 (ALDH2) 53630 (BCO1) 8228 (PNPLA4) 124 (ADH1A)
125 (ADH1B) 1.00 0.35 0.72 0.18 0.31 0.39 0.28 0.23 0.27 0.22 0.69
1571 (CYP2E1) 0.35 1.00 0.39 0.30 0.50 0.59 0.79 0.43 0.55 0.37 0.55
126 (ADH1C) 0.72 0.39 1.00 0.24 0.37 0.55 0.26 0.28 0.31 0.25 0.88
9227 (LRAT) 0.18 0.30 0.24 1.00 0.27 0.38 0.21 0.23 0.26 0.30 0.24
316 (AOX1) 0.31 0.50 0.37 0.27 1.00 0.58 0.39 0.60 0.44 0.29 0.38
54884 (RETSAT) 0.39 0.59 0.55 0.38 0.58 1.00 0.40 0.44 0.55 0.39 0.50
1592 (CYP26A1) 0.28 0.79 0.26 0.21 0.39 0.40 1.00 0.35 0.33 0.29 0.39
217 (ALDH2) 0.23 0.43 0.28 0.23 0.60 0.44 0.35 1.00 0.31 0.35 0.32
53630 (BCO1) 0.27 0.55 0.31 0.26 0.44 0.55 0.33 0.31 1.00 0.25 0.31
8228 (PNPLA4) 0.22 0.37 0.25 0.30 0.29 0.39 0.29 0.35 0.25 1.00 0.31
124 (ADH1A) 0.69 0.55 0.88 0.24 0.38 0.50 0.39 0.32 0.31 0.31 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ADH1C Human Blood - 3250 m 4 day upregulated 2.4322 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
126 GO:0004024 alcohol dehydrogenase GOTERM_MF_DIRECT
126 GO:0016491 tRNA GOTERM_MF_DIRECT
126 GO:0004745 purine-nucleoside phosphorylase activity GOTERM_MF_DIRECT
126 GO:0006069 ethanol oxidation GOTERM_BP_DIRECT
126 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
126 GO:0004022 N6- GOTERM_MF_DIRECT
126 GO:0005829 cytosol GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
126 hsa00071 Fatty acid degradation
126 hsa00010 Glycolysis / Gluconeogenesis
126 hsa00350 Tyrosine metabolism
126 hsa01100 Metabolic pathways
126 hsa00982 Drug metabolism - cytochrome P450
126 hsa00980 Metabolism of xenobiotics by cytochrome P450
126 hsa00830 Retinol metabolism
126 hsa05204 Chemical carcinogenesis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ADH1C 126 Mouth Neoplasms C0026640 Neoplastic Process 0.3 0.567 0.655 group
ADH1C 126 Malignant neoplasm of mouth C0153381 Neoplastic Process 0.33 0.567 0.655 disease
ADH1C 126 Alcohol Use Disorder C0001956 Mental or Behavioral Dysfunction 0.32 0.567 0.655 disease
ADH1C 126 PARKINSON DISEASE, LATE-ONSET C3160718 Disease or Syndrome 0.3 0.567 0.655 disease
ADH1C 126 Alcoholic Intoxication, Chronic C0001973 Mental or Behavioral Dysfunction 0.7 0.567 0.655 disease
ADH1C 126 Alcohol abuse C0085762 Mental or Behavioral Dysfunction 0.53 0.567 0.655 disease
ADH1C 126 Alcoholic Intoxication C0001969 Mental or Behavioral Dysfunction 0.32 0.567 0.655 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ADH1C 126 FOMEPIZOLE FOMEPIZOLE CHEMBL1308 None
ADH1C 126 FOMEPIZOLE FOMEPIZOLE CHEMBL1308 inhibitor
ADH1C 126 FOMEPIZOLE FOMEPIZOLE CHEMBL1308 None
ADH1C 126 RETINOIC ACID TRETINOIN CHEMBL38 None