Alcohol dehydrogenase 1A (class I), alpha polypeptide
AltitudeomicsDB
| Protein Official symbol |
ADH1A |
| Aliases |
ADH1A ADH1 |
| Chromosomal Location |
4 |
| Length |
375 |
| Uniprot ID |
P07327 |
| EC number |
1.1.1.1 |
| Protein family Information(Pfam) |
PF08240;PF00107; |
| PDB id |
1HSO;1U3T; |
| InterPro ID |
IPR013149;IPR013154;IPR002328;IPR011032;IPR036291;IPR020843; |
| dbSNP |
None |
AltitudeomicsDB
| Protein 1 |
Protein 2 |
Combine Score |
| ADH1B |
ALDH2 |
0.993 |
| ADH1B |
ADH1A |
0.982 |
| CYP2E1 |
ADH1C |
0.974 |
| CYP2E1 |
ADH1B |
0.974 |
| ADH1C |
ADH1B |
0.973 |
| CYP2E1 |
ALDH2 |
0.973 |
| LRAT |
CYP26A1 |
0.97 |
| CYP2E1 |
ADH1A |
0.962 |
| ADH1C |
ALDH2 |
0.946 |
| AOX1 |
ADH1B |
0.938 |
| LRAT |
RETSAT |
0.937 |
| LRAT |
ADH1A |
0.935 |
| CYP26A1 |
ADH1A |
0.935 |
| RETSAT |
CYP26A1 |
0.935 |
| AOX1 |
ADH1A |
0.929 |
| ADH1C |
CYP26A1 |
0.924 |
| AOX1 |
BCO1 |
0.923 |
| ADH1C |
LRAT |
0.923 |
| RETSAT |
ADH1A |
0.922 |
| LRAT |
ADH1B |
0.918 |
| ADH1C |
AOX1 |
0.918 |
| ADH1B |
CYP26A1 |
0.918 |
| ADH1C |
ADH1A |
0.916 |
| ADH1C |
RETSAT |
0.913 |
| AOX1 |
CYP26A1 |
0.912 |
| ADH1C |
BCO1 |
0.911 |
| ALDH2 |
ADH1A |
0.909 |
| BCO1 |
ADH1A |
0.905 |
| ADH1B |
RETSAT |
0.903 |
| ADH1B |
BCO1 |
0.903 |
| PNPLA4 |
ADH1A |
0.9 |
| PNPLA4 |
ADH1B |
0.9 |
| PNPLA4 |
CYP26A1 |
0.9 |
| PNPLA4 |
RETSAT |
0.9 |
| ADH1C |
PNPLA4 |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
| # |
217 (ALDH2) |
124 (ADH1A) |
126 (ADH1C) |
125 (ADH1B) |
1592 (CYP26A1) |
54884 (RETSAT) |
53630 (BCO1) |
9227 (LRAT) |
316 (AOX1) |
8228 (PNPLA4) |
1571 (CYP2E1) |
|
217 (ALDH2)
|
1.00
|
0.32
|
0.28
|
0.23
|
0.35
|
0.44
|
0.26
|
0.23
|
0.44
|
0.18
|
0.42
|
|
124 (ADH1A)
|
0.32
|
1.00
|
0.88
|
0.69
|
0.39
|
0.50
|
0.28
|
0.24
|
0.43
|
0.19
|
0.53
|
|
126 (ADH1C)
|
0.28
|
0.88
|
1.00
|
0.72
|
0.26
|
0.55
|
0.29
|
0.24
|
0.20
|
0.19
|
0.39
|
|
125 (ADH1B)
|
0.23
|
0.69
|
0.72
|
1.00
|
0.28
|
0.39
|
0.22
|
0.18
|
0.34
|
0.15
|
0.35
|
|
1592 (CYP26A1)
|
0.35
|
0.39
|
0.26
|
0.28
|
1.00
|
0.39
|
0.24
|
0.21
|
0.40
|
0.16
|
0.78
|
|
54884 (RETSAT)
|
0.44
|
0.50
|
0.55
|
0.39
|
0.39
|
1.00
|
0.48
|
0.38
|
0.32
|
0.32
|
0.60
|
|
53630 (BCO1)
|
0.26
|
0.28
|
0.29
|
0.22
|
0.24
|
0.48
|
1.00
|
0.26
|
0.19
|
0.21
|
0.35
|
|
9227 (LRAT)
|
0.23
|
0.24
|
0.24
|
0.18
|
0.21
|
0.38
|
0.26
|
1.00
|
0.18
|
0.23
|
0.30
|
|
316 (AOX1)
|
0.44
|
0.43
|
0.20
|
0.34
|
0.40
|
0.32
|
0.19
|
0.18
|
1.00
|
0.13
|
0.48
|
|
8228 (PNPLA4)
|
0.18
|
0.19
|
0.19
|
0.15
|
0.16
|
0.32
|
0.21
|
0.23
|
0.13
|
1.00
|
0.23
|
|
1571 (CYP2E1)
|
0.42
|
0.53
|
0.39
|
0.35
|
0.78
|
0.60
|
0.35
|
0.30
|
0.48
|
0.23
|
1.00
|
Association with High Altitude
| Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
| ADH1A |
Human |
Blood |
- |
3250 m |
4 day |
upregulated |
2.4322 |
Microarray |
Himalayas |
Indians |
1 |
Sea level healthy individuals |
24465776 |
| ADH1A |
Rat |
Kidney |
- |
7628 m |
7 day |
downregulated |
-7.28 |
2-DE |
northern Indo-Australian Plate |
Male sprague-dawley |
1 |
Male SD rats weighing 250-260g |
30005088 |
Association with TF
| TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
| GATA2 |
2624 |
ADH1A |
124 |
Repression |
24173718 |
TRUSST |
Association with miRNA
| miRTarBase ID |
miRNA |
Species (miRNA) |
Protein Official Symbol |
Human Entrez ID |
Species (Target Gene) |
Experiments |
Support Type |
References (PMID) |
| MIRT021722 |
hsa-miR-132-3p |
Homo sapiens |
ADH1A |
124 |
Homo sapiens |
Microarray |
Functional MTI (Weak) |
17612493 |
Gene Ontology
| ID |
GO ID |
GO Term |
GO Type |
| 124 |
GO:0006066 |
alcohol metabolic process |
GOTERM_BP_DIRECT |
| 124 |
GO:0004022 |
adenosylmethionine decarboxylase activity |
GOTERM_MF_DIRECT |
| 124 |
GO:0008270 |
zinc ion binding |
GOTERM_MF_DIRECT |
| 124 |
GO:0004745 |
protein tyrosine phosphatase activity |
GOTERM_MF_DIRECT |
| 124 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
| 124 |
GO:0005829 |
cytosol |
GOTERM_CC_DIRECT |
| 124 |
GO:0006069 |
ethanol oxidation |
GOTERM_BP_DIRECT |
| 124 |
GO:0017144 |
drug metabolic process |
GOTERM_BP_DIRECT |
| 124 |
GO:0004024 |
L-alanine:2-oxoglutarate aminotransferase activity |
GOTERM_MF_DIRECT |
Pathways
| Human Entrez ID |
KEGG ID |
KEGG Term |
| 124 |
hsa00010 |
Glycolysis / Gluconeogenesis |
| 124 |
hsa00071 |
Fatty acid degradation |
| 124 |
hsa00350 |
Tyrosine metabolism |
| 124 |
hsa00982 |
Drug metabolism - cytochrome P450 |
| 124 |
hsa00980 |
Metabolism of xenobiotics by cytochrome P450 |
| 124 |
hsa01100 |
Metabolic pathways |
| 124 |
hsa00830 |
Retinol metabolism |
| 124 |
hsa05204 |
Chemical carcinogenesis |
Association with Disease
| Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
| ADH1A |
124 |
Alcoholic Intoxication, Chronic |
C0001973 |
Mental or Behavioral Dysfunction |
0.33 |
0.676 |
0.448 |
disease |
Association with Drug
| Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |
| ADH1A |
124 |
FOMEPIZOLE |
FOMEPIZOLE |
CHEMBL1308 |
None |
| ADH1A |
124 |
FOMEPIZOLE |
FOMEPIZOLE |
CHEMBL1308 |
inhibitor |
| ADH1A |
124 |
FOMEPIZOLE |
FOMEPIZOLE |
CHEMBL1308 |
None |