Alcohol dehydrogenase 1B (class I), beta polypeptide

AltitudeomicsDB
Protein Official symbol ADH1B
Aliases ADH1B ADH2
Chromosomal Location 4
Length 375
Uniprot ID P00325
EC number 1.1.1.105
Protein family Information(Pfam) PF08240;PF00107;
PDB id 1DEH;1HDX;1HDY;1HDZ;1HSZ;1HTB;1U3U;1U3V;3HUD;
InterPro ID IPR013149;IPR013154;IPR002328;IPR011032;IPR036291;IPR020843;
dbSNP rs1229984 rs1041969 rs6413413 rs2066702

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SULT1A2 SULT1A1 0.995
ADH1B ALDH2 0.993
COMT MAOA 0.987
ADH1B ADH1A 0.982
CYP2E1 ADH1C 0.9740000000000001
CYP2E1 ADH1B 0.9740000000000001
CYP2E1 ALDH2 0.973
ADH1C ADH1B 0.973
LRAT CYP26A1 0.97
CYP2E1 ADH1A 0.9620000000000001
ALDH3A2 ADH1B 0.948
ADH1C ALDH2 0.946
CYP2E1 ALDH3A2 0.9440000000000001
MAOA ALDH2 0.9420000000000001
COMT ADH1B 0.94
MAOA ADH1B 0.938
AOX1 ADH1B 0.938
COMT ALDH2 0.938
LRAT RETSAT 0.937
AOX1 MAOA 0.937
RETSAT CYP26A1 0.935
LRAT ADH1A 0.935
CYP26A1 ADH1A 0.935
AOX1 ADH1A 0.929
ALDH3A2 MAOA 0.9279999999999999
ADH1C CYP26A1 0.924
ADH1C LRAT 0.9229999999999999
AOX1 BCO1 0.9229999999999999
RETSAT ADH1A 0.922
LRAT ADH1B 0.9179999999999999
COMT ALDH3A2 0.9179999999999999
ADH1B CYP26A1 0.9179999999999999
ADH1C AOX1 0.9179999999999999
ADH1C ADH1A 0.9159999999999999
ADH1C RETSAT 0.9129999999999999
SULT1A1 ADH1B 0.9129999999999999
AOX1 CYP26A1 0.912
ADH1C BCO1 0.9109999999999999
ALDH2 ADH1A 0.909
ADH1B UGT2B10 0.9059999999999999
BCO1 ADH1A 0.905
ADH1B BCO1 0.903
ADH1B RETSAT 0.903
UGT2B11 ADH1B 0.902
SULT1A2 ADH1B 0.902
PNPLA4 CYP26A1 0.9
PNPLA4 ADH1B 0.9
PNPLA4 RETSAT 0.9
ADH1C PNPLA4 0.9
PNPLA4 ADH1A 0.9
Gene Ontology Semantic Similarity
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# 6799 (SULT1A2) 125 (ADH1B) 1312 (COMT) 1571 (CYP2E1) 126 (ADH1C) 9227 (LRAT) 224 (ALDH3A2) 4128 (MAOA) 316 (AOX1) 54884 (RETSAT) 1592 (CYP26A1) 6817 (SULT1A1) 217 (ALDH2) 53630 (BCO1) 10720 (UGT2B11) 8228 (PNPLA4) 124 (ADH1A)
6799 (SULT1A2) 1.00 0.23 0.56 0.45 0.21 0.42 0.21 0.24 0.27 0.34 0.33 0.98 0.26 0.22 0.36 0.33 0.41
125 (ADH1B) 0.23 1.00 0.23 0.35 0.72 0.18 0.32 0.29 0.31 0.39 0.28 0.22 0.23 0.27 0.16 0.22 0.69
1312 (COMT) 0.56 0.23 1.00 0.44 0.20 0.41 0.20 0.24 0.26 0.33 0.32 0.54 0.25 0.22 0.36 0.32 0.41
1571 (CYP2E1) 0.45 0.35 0.44 1.00 0.39 0.30 0.37 0.60 0.50 0.59 0.79 0.44 0.43 0.55 0.31 0.37 0.55
126 (ADH1C) 0.21 0.72 0.20 0.39 1.00 0.24 0.46 0.34 0.37 0.55 0.26 0.21 0.28 0.31 0.18 0.25 0.88
9227 (LRAT) 0.42 0.18 0.41 0.30 0.24 1.00 0.24 0.28 0.27 0.38 0.21 0.43 0.23 0.26 0.43 0.30 0.24
224 (ALDH3A2) 0.21 0.32 0.20 0.37 0.46 0.24 1.00 0.34 0.48 0.55 0.25 0.21 0.56 0.31 0.18 0.25 0.41
4128 (MAOA) 0.24 0.29 0.24 0.60 0.34 0.28 0.34 1.00 0.48 0.60 0.36 0.24 0.34 0.31 0.18 0.28 0.34
316 (AOX1) 0.27 0.31 0.26 0.50 0.37 0.27 0.48 0.48 1.00 0.58 0.39 0.27 0.60 0.44 0.25 0.29 0.38
54884 (RETSAT) 0.34 0.39 0.33 0.59 0.55 0.38 0.55 0.60 0.58 1.00 0.40 0.35 0.44 0.55 0.31 0.39 0.50
1592 (CYP26A1) 0.33 0.28 0.32 0.79 0.26 0.21 0.25 0.36 0.39 0.40 1.00 0.32 0.35 0.33 0.19 0.29 0.39
6817 (SULT1A1) 0.98 0.22 0.54 0.44 0.21 0.43 0.21 0.24 0.27 0.35 0.32 1.00 0.25 0.22 0.36 0.32 0.39
217 (ALDH2) 0.26 0.23 0.25 0.43 0.28 0.23 0.56 0.34 0.60 0.44 0.35 0.25 1.00 0.31 0.18 0.35 0.32
53630 (BCO1) 0.22 0.27 0.22 0.55 0.31 0.26 0.31 0.31 0.44 0.55 0.33 0.22 0.31 1.00 0.17 0.25 0.31
10720 (UGT2B11) 0.36 0.16 0.36 0.31 0.18 0.43 0.18 0.18 0.25 0.31 0.19 0.36 0.18 0.17 1.00 0.24 0.18
8228 (PNPLA4) 0.33 0.22 0.32 0.37 0.25 0.30 0.25 0.28 0.29 0.39 0.29 0.32 0.35 0.25 0.24 1.00 0.31
124 (ADH1A) 0.41 0.69 0.41 0.55 0.88 0.24 0.41 0.34 0.38 0.50 0.39 0.39 0.32 0.31 0.18 0.31 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ADH1B Human Blood - 3250 m 4 day upregulated 2.4322 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
JUNB 3726 ADH1B 125 distal 22955619 TRANSFAC
CEBPB 1051 ADH1B 125 distal 22955619 TRANSFAC
JUND 3727 ADH1B 125 distal 22955619 TRANSFAC
FOS 2353 ADH1B 125 distal 22955619 TRANSFAC
CTCF 10664 ADH1B 125 distal 22955619 TRANSFAC
JUN 3725 ADH1B 125 distal 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT504583 hsa-miR-1277-5p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT504584 hsa-miR-190a-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT504583 hsa-miR-1277-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504583 hsa-miR-1277-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT504584 hsa-miR-190a-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT504588 hsa-miR-5011-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504589 hsa-miR-4280 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT504588 hsa-miR-5011-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT504584 hsa-miR-190a-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504586 hsa-miR-3189-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504587 hsa-miR-5699-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT504586 hsa-miR-3189-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT504588 hsa-miR-5011-5p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT504585 hsa-miR-4758-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504587 hsa-miR-5699-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504585 hsa-miR-4758-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT504589 hsa-miR-4280 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518100 hsa-let-7f-1-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518107 hsa-miR-381-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518101 hsa-let-7b-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518102 hsa-let-7a-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT518104 hsa-miR-4666a-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT518106 hsa-miR-34b-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518099 hsa-miR-98-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518100 hsa-let-7f-1-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT518103 hsa-miR-4705 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518103 hsa-miR-4705 Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT518108 hsa-miR-300 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518108 hsa-miR-300 Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT518099 hsa-miR-98-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518106 hsa-miR-34b-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518105 hsa-miR-5580-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518099 hsa-miR-98-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT518108 hsa-miR-300 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518101 hsa-let-7b-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT518103 hsa-miR-4705 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518104 hsa-miR-4666a-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518107 hsa-miR-381-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT518102 hsa-let-7a-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518108 hsa-miR-300 Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT518107 hsa-miR-381-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518101 hsa-let-7b-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518102 hsa-let-7a-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT518105 hsa-miR-5580-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT518100 hsa-let-7f-1-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518104 hsa-miR-4666a-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT518106 hsa-miR-34b-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT518107 hsa-miR-381-3p Homo sapiens ADH1B 125 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT551502 hsa-miR-297 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT551503 hsa-miR-568 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT551501 hsa-miR-3149 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT551507 hsa-miR-511-3p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT551505 hsa-miR-223-5p Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT551506 hsa-miR-567 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT551504 hsa-miR-3924 Homo sapiens ADH1B 125 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
Gene Ontology
ID GO ID GO Term GO Type
125 GO:0006069 ethanol oxidation GOTERM_BP_DIRECT
125 GO:0004024 alcohol dehydrogenase GOTERM_MF_DIRECT
125 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
125 GO:0016491 1-phosphatidylinositol-3-kinase activity GOTERM_MF_DIRECT
125 GO:0005829 cytosol GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
125 hsa00071 Fatty acid degradation
125 hsa00010 Glycolysis / Gluconeogenesis
125 hsa00350 Tyrosine metabolism
125 hsa00982 Drug metabolism - cytochrome P450
125 hsa00980 Metabolism of xenobiotics by cytochrome P450
125 hsa01100 Metabolic pathways
125 hsa00830 Retinol metabolism
125 hsa05204 Chemical carcinogenesis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ADH1B 125 Esophageal Neoplasms C0014859 Neoplastic Process 0.4 0.525 0.759 group
ADH1B 125 Mouth Neoplasms C0026640 Neoplastic Process 0.3 0.525 0.759 group
ADH1B 125 Anterior Choroidal Artery Infarction C0751012 Disease or Syndrome 0.3 0.525 0.759 disease
ADH1B 125 Posterior Choroidal Artery Infarction C0887799 Disease or Syndrome 0.3 0.525 0.759 phenotype
ADH1B 125 Cerebral Infarction, Left Hemisphere C0751010 Disease or Syndrome 0.3 0.525 0.759 disease
ADH1B 125 Subcortical Infarction C0751014 Disease or Syndrome 0.3 0.525 0.759 disease
ADH1B 125 Alcohol Use Disorder C0001956 Mental or Behavioral Dysfunction 0.4 0.525 0.759 disease
ADH1B 125 Colorectal Neoplasms C0009404 Neoplastic Process 0.32 0.525 0.759 group
ADH1B 125 Malignant neoplasm of mouth C0153381 Neoplastic Process 0.4 0.525 0.759 disease
ADH1B 125 Laryngeal neoplasm C0023055 Neoplastic Process 0.3 0.525 0.759 disease
ADH1B 125 Squamous cell carcinoma of esophagus C0279626 Neoplastic Process 0.4 0.525 0.759 disease
ADH1B 125 Cerebral Infarction, Right Hemisphere C0751011 Disease or Syndrome 0.3 0.525 0.759 disease
ADH1B 125 Malignant neoplasm of pharynx C0153405 Neoplastic Process 0.41 0.525 0.759 disease
ADH1B 125 Colorectal Cancer C1527249 Neoplastic Process 0.35 0.525 0.759 disease
ADH1B 125 Pharyngeal Neoplasms C0031347 Neoplastic Process 0.3 0.525 0.759 group
ADH1B 125 Malignant neoplasm of esophagus C0546837 Neoplastic Process 0.4 0.525 0.759 disease
ADH1B 125 Malignant neoplasm of larynx C0007107 Neoplastic Process 0.31 0.525 0.759 disease
ADH1B 125 Cerebral Infarction C0007785 Disease or Syndrome 0.31 0.525 0.759 disease
ADH1B 125 Obesity C0028754 Disease or Syndrome 0.31 0.525 0.759 disease
ADH1B 125 Colorectal Carcinoma C0009402 Neoplastic Process 0.35 0.525 0.759 disease
ADH1B 125 Alcohol abuse C0085762 Mental or Behavioral Dysfunction 0.58 0.525 0.759 disease
ADH1B 125 Alcoholic Intoxication, Chronic C0001973 Mental or Behavioral Dysfunction 0.7 0.525 0.759 disease
ADH1B 125 Alcoholic Intoxication C0001969 Mental or Behavioral Dysfunction 0.33 0.525 0.759 disease
ADH1B 125 Wernicke-Korsakoff Syndrome C0349464 Mental or Behavioral Dysfunction 0.31 0.525 0.759 disease
ADH1B 125 Hangover from alcohol C0393756 Sign or Symptom 0.3 0.525 0.759 phenotype
ADH1B 125 Psychotic Disorders C0033975 Mental or Behavioral Dysfunction 0.32 0.525 0.759 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ADH1B 125 FOMEPIZOLE FOMEPIZOLE CHEMBL1308 None
ADH1B 125 FOMEPIZOLE FOMEPIZOLE CHEMBL1308 inhibitor
ADH1B 125 FOMEPIZOLE FOMEPIZOLE CHEMBL1308 None