Sulfotransferase 1A1

AltitudeomicsDB
Protein Official symbol SULT1A1
Aliases SULT1A1 STP STP1 OK/SW-cl.88
Chromosomal Location  16
Length 295
Uniprot ID P50225
EC number 2.8.2.1
Protein family Information(Pfam) PF00685;
PDB id 1LS6;1Z28;2D06;3QVU;3QVV;3U3J;3U3K;3U3M;3U3O;3U3R;4GRA;
InterPro ID IPR027417;IPR000863;
dbSNP rs72547527 rs1042014 rs1042011 rs1042028 rs1801030 rs35728980 rs36043491

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SULT1A2 SULT1A1 0.975
SULT1A1 ADH1B 0.913
SULT1A1 DIO1 0.906
SULT1A1 ADH6 0.902
SULT1A2 ADH1B 0.902
DIO2 SULT1A2 0.902
DIO2 SULT1A1 0.902
SULT1A2 DIO1 0.902
SULT1A2 ADH6 0.902
Gene Ontology Semantic Similarity
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# 6817 (SULT1A1) 125 (ADH1B) 1733 (DIO1) 130 (ADH6) 6799 (SULT1A2) 1734 (DIO2)
6817 (SULT1A1) 1.00 0.23 0.38 0.24 0.98 0.41
125 (ADH1B) 0.23 1.00 0.37 0.97 0.23 0.33
1733 (DIO1) 0.38 0.37 1.00 0.41 0.40 0.87
130 (ADH6) 0.24 0.97 0.41 1.00 0.25 0.37
6799 (SULT1A2) 0.98 0.23 0.40 0.25 1.00 0.43
1734 (DIO2) 0.41 0.33 0.87 0.37 0.43 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
SULT1A1 Rat Plasma - 7620 m 12 hours upregulated 1.6 2-DE Northern indo-australian plate Sprague-dawley rats 1 Male SD rats weighing 220g 24842778
SULT1A1 Rat Lungs - 7600 m 24 hours upregulated 5.2 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
SULT1A1 Rat Lungs - 7600 m 6 hours upregulated 1.2 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
SULT1A1 Rat Plasma - 7620 m 24 hours upregulated 1.33 2-DE Northern indo-australian plate Sprague-dawley rats 1 Male SD rats weighing 220g 24842778
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
CEBPB 1051 SULT1A1 6817 distal 22955619 TRANSFAC
MAX 4149 SULT1A1 6817 distal 22955619 TRANSFAC
FOS 2353 SULT1A1 6817 distal 22955619 TRANSFAC
GATA2 2624 SULT1A1 6817 distal 22955619 TRANSFAC
CTCF 10664 SULT1A1 6817 distal 22955619 TRANSFAC
JUND 3727 SULT1A1 6817 distal 22955619 TRANSFAC
TAF1 6872 SULT1A1 6817 distal 22955619 TRANSFAC
YY1 7528 SULT1A1 6817 distal 22955619 TRANSFAC
SMARCA4 6597 SULT1A1 6817 distal 22955619 TRANSFAC
SPI1 6688 SULT1A1 6817 distal 22955619 TRANSFAC
CCNT2 905 SULT1A1 6817 distal 22955619 TRANSFAC
GABPA 2551 SULT1A1 6817 distal 22955619 TRANSFAC
HMGN3 9324 SULT1A1 6817 distal 22955619 TRANSFAC
HEY1 23462 SULT1A1 6817 distal 22955619 TRANSFAC
GATA1 2623 SULT1A1 6817 distal 22955619 TRANSFAC
TAL1 6886 SULT1A1 6817 distal 22955619 TRANSFAC
EP300 2033 SULT1A1 6817 distal 22955619 TRANSFAC
HDAC2 3066 SULT1A1 6817 distal 22955619 TRANSFAC
RAD21 5885 SULT1A1 6817 distal 22955619 TRANSFAC
E2F6 1876 SULT1A1 6817 distal 22955619 TRANSFAC
EGR1 1958 SULT1A1 6817 distal 22955619 TRANSFAC
TBP 6908 SULT1A1 6817 distal 22955619 TRANSFAC
MAFK 7975 SULT1A1 6817 proximal_filtered 22955619 TRANSFAC
MAFF 23764 SULT1A1 6817 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT004760 hsa-miR-631 Homo sapiens SULT1A1 6817 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 20881232
Gene Ontology
ID GO ID GO Term GO Type
6817 GO:0008202 steroid metabolic process GOTERM_BP_DIRECT
6817 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
6817 GO:0009812 flavonoid metabolic process GOTERM_BP_DIRECT
6817 GO:0004062 aminoacylase activity GOTERM_MF_DIRECT
6817 GO:0047894 CDP-glycerol diphosphatase activity GOTERM_MF_DIRECT
6817 GO:0006584 catecholamine metabolic process GOTERM_BP_DIRECT
6817 GO:0005829 cytosol GOTERM_CC_DIRECT
6817 GO:0006805 xenobiotic metabolic process GOTERM_BP_DIRECT
6817 GO:0051923 sulfation GOTERM_BP_DIRECT
6817 GO:0050294 inositol oxygenase activity GOTERM_MF_DIRECT
6817 GO:0009308 amine metabolic process GOTERM_BP_DIRECT
6817 GO:0008210 estrogen metabolic process GOTERM_BP_DIRECT
6817 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process GOTERM_BP_DIRECT
6817 GO:0005515 protein binding GOTERM_MF_DIRECT
6817 GO:0008146 drug binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
6817 hsa05204 Chemical carcinogenesis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
SULT1A1 6817 Chromosome Aberrations C0008625 Cell or Molecular Dysfunction 0.3 0.564 0.517 group
SULT1A1 6817 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.33 0.564 0.517 disease
SULT1A1 6817 Myocardial Ischemia C0151744 Disease or Syndrome 0.3 0.564 0.517 disease
SULT1A1 6817 Cancer of Urinary Tract C0751571 Neoplastic Process 0.3 0.564 0.517 disease
SULT1A1 6817 Prostatic Neoplasms C0033578 Neoplastic Process 0.31 0.564 0.517 group
SULT1A1 6817 Autosome Abnormalities C0004403 Cell or Molecular Dysfunction 0.3 0.564 0.517 group
SULT1A1 6817 Malignant tumor of colon C0007102 Neoplastic Process 0.31 0.564 0.517 disease
SULT1A1 6817 Urologic Neoplasms C0042076 Neoplastic Process 0.3 0.564 0.517 group
SULT1A1 6817 Genomic Instability C0919532 Cell or Molecular Dysfunction 0.3 0.564 0.517 phenotype
SULT1A1 6817 Colonic Neoplasms C0009375 Neoplastic Process 0.3 0.564 0.517 group
SULT1A1 6817 Depressive Symptoms C0086132 Sign or Symptom 0.31 0.564 0.517 phenotype
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types