ALTITUDEOMICSDB

Plasma retinol binding protein precursor

Protein Official symbol	RBP4
Aliases	RBP4 PRO2222
Chromosomal Location	10
Length	201
Uniprot ID	P02753
EC number	None
Protein family Information(Pfam)	PF00061;
PDB id	1BRP;1BRQ;1JYD;1JYJ;1QAB;1RBP;1RLB;2WQ9;2WQA;2WR6;3BSZ;3FMZ;4O9S;4PSQ;5NTY;5NU2;5NU6;5NU7;5NU8;5NU9;5NUA;5NUB;
InterPro ID	IPR012674;IPR022271;IPR022272;IPR000566;IPR002449;
dbSNP	rs121918584 rs794726862 rs794726861 rs121918585

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Showing 1 to 10 of 12 entries

#	5950 (RBP4)	64220 (STRA6)	7276 (TTR)	221223 (CES5A)	283848 (CES4A)	5947 (RBP1)	5948 (RBP2)	1066 (CES1)	83758 (RBP5)	8824 (CES2)
5950 (RBP4)	1.00	1.00	0.62	0.14	0.14	0.60	0.66	0.14	0.70	0.18
64220 (STRA6)	1.00	1.00	0.17	0.12	0.12	0.12	0.12	0.12	0.17	0.12
7276 (TTR)	0.62	0.17	1.00	0.16	0.16	0.35	0.41	0.16	0.74	0.18
221223 (CES5A)	0.14	0.12	0.16	1.00	1.00	0.10	0.12	1.00	0.15	1.00
283848 (CES4A)	0.14	0.12	0.16	1.00	1.00	0.10	0.12	1.00	0.15	1.00
5947 (RBP1)	0.60	0.12	0.35	0.10	0.10	1.00	1.00	0.10	0.76	0.12
5948 (RBP2)	0.66	0.12	0.41	0.12	0.12	1.00	1.00	0.12	1.00	0.12
1066 (CES1)	0.14	0.12	0.16	1.00	1.00	0.10	0.12	1.00	0.15	1.00
83758 (RBP5)	0.70	0.17	0.74	0.15	0.15	0.76	1.00	0.15	1.00	0.18
8824 (CES2)	0.18	0.12	0.18	1.00	1.00	0.12	0.12	1.00	0.18	1.00

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Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
RBP4	Human	Plasma	-	3500 m	4 day	upregulated	0.393±0.043	2-DE	Northern indo-australian plate	Indians	0.191±0.030	healthy sea level controls	21755356
RBP4	Toad	Heart	-	3464 m	33 day	downregulated	-2.282577677	RNA-seq	Tibetan Plateau	Asiatic toad	1	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	28673260
RBP4	Human	Plasma	-	3500-4000m	Native	downregulated	-1.87	2-DE	Northern indo-australian plate	Ladakhi	1	Sea level healthy individuals	23844025

Showing 1 to 3 of 3 entries

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TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
CEBPB	1051	RBP4	5950	proximal_filtered	22955619	TRANSFAC
E2F6	1876	RBP4	5950	distal	22955619	TRANSFAC
MAX	4149	RBP4	5950	distal	22955619	TRANSFAC
MYC	4609	RBP4	5950	distal	22955619	TRANSFAC
TAF1	6872	RBP4	5950	distal	22955619	TRANSFAC
TAL1	6886	RBP4	5950	distal	22955619	TRANSFAC
USF1	7391	RBP4	5950	distal	22955619	TRANSFAC
YY1	7528	RBP4	5950	distal	22955619	TRANSFAC

Showing 1 to 8 of 8 entries

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miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
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ID	GO ID	GO Term	GO Type
5950	GO:0006094	gluconeogenesis	GOTERM_BP_DIRECT
5950	GO:0007507	heart development	GOTERM_BP_DIRECT
5950	GO:0001523	retinoid metabolic process	GOTERM_BP_DIRECT
5950	GO:0007601	visual perception	GOTERM_BP_DIRECT
5950	GO:0030324	lung development	GOTERM_BP_DIRECT
5950	GO:0030277	maintenance of gastrointestinal epithelium	GOTERM_BP_DIRECT
5950	GO:0001654	eye development	GOTERM_BP_DIRECT
5950	GO:0032024	positive regulation of insulin secretion	GOTERM_BP_DIRECT
5950	GO:0060065	uterus development	GOTERM_BP_DIRECT
5950	GO:0060347	heart trabecula formation	GOTERM_BP_DIRECT

Showing 1 to 10 of 37 entries

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Human Entrez ID	KEGG ID	KEGG Term
No data available in table

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Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
RBP4	5950	Heart failure	C0018801	Disease or Syndrome	0.3	0.534	0.724	disease
RBP4	5950	Mammary Neoplasms, Experimental	C0024668	Experimental Model of Disease; Neoplastic Process	0.3	0.534	0.724	group
RBP4	5950	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.31	0.534	0.724	disease
RBP4	5950	Necrosis	C0027540	Organ or Tissue Function	0.3	0.534	0.724	phenotype
RBP4	5950	Carcinoma	C0007097	Neoplastic Process	0.3	0.534	0.724	group
RBP4	5950	Animal Mammary Neoplasms	C0024667	Neoplastic Process	0.3	0.534	0.724	group
RBP4	5950	Spontaneous abortion	C0000786	Pathologic Function	0.3	0.534	0.724	phenotype
RBP4	5950	Left-Sided Heart Failure	C0023212	Disease or Syndrome	0.3	0.534	0.724	disease
RBP4	5950	Alcoholic Liver Diseases	C0023896	Disease or Syndrome	0.3	0.534	0.724	group
RBP4	5950	Polycystic Ovary Syndrome	C0032460	Disease or Syndrome	0.32	0.534	0.724	disease

Showing 1 to 10 of 32 entries

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Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
RBP4	5950	A1120	GENISTEIN	CHEMBL44	inhibitor
RBP4	5950	FENRETINIDE	FENRETINIDE	CHEMBL7301	None
RBP4	5950	ROSIGLITAZONE	ROSIGLITAZONE	CHEMBL121	None

Showing 1 to 3 of 3 entries