Complement C1q A Chain

AltitudeomicsDB
Protein Official symbol C1QA
Aliases C1QA
Chromosomal Location  1
Length 245
Uniprot ID P02745
EC number None
Protein family Information(Pfam) PF00386;PF01391;
PDB id 1PK6;2JG8;2JG9;2WNU;2WNV;5HKJ;5HZF;6FCZ;
InterPro ID IPR001073;IPR008160;IPR037572;IPR008983;
dbSNP rs17887074

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
C1QA C1QB 0.999
C1QC C1QB 0.998
C1QA C1QC 0.996
C1R SERPING1 0.992
C1S SERPING1 0.99
C1R C1S 0.988
C4B C1S 0.983
C4A C1S 0.983
C1R C4A 0.977
C1R C4B 0.977
C4B C4A 0.976
C1S C1QB 0.972
C1S C1QC 0.97
C1R C1QC 0.968
C1QB SERPING1 0.968
VSIG4 C1QB 0.967
VSIG4 C1QA 0.966
C1QA SERPING1 0.965
C1R C1QB 0.965
CSF1R TYROBP 0.964
C4B C1QB 0.963
C4A C2 0.962
C4B C2 0.962
C4A C1QB 0.961
C1QC SERPING1 0.961
C4A C1QC 0.959
C1R C1QA 0.959
C4B C1QC 0.959
C1S C1QA 0.959
C4B C1QA 0.957
C4A C1QA 0.955
C1R C2 0.948
C1R CRP 0.938
C1S CRP 0.938
C1QC C2 0.937
IGHV3-11 IGLL5 0.933
C1QA TYROBP 0.932
C1QB C2 0.932
IGLL5 C1QA 0.928
C1S C2 0.927
C1QA CRP 0.923
C1QC CRP 0.92
C1QA C2 0.92
IGLL5 C1QB 0.913
C1QB CSF1R 0.913
C1QB CRP 0.911
IGLL5 C4B 0.909
IGLL5 C1QC 0.909
IGLL5 C4A 0.907
IGLL5 C2 0.902
IGHV3-11 C2 0.9
C1R IGLL5 0.9
IGHV3-11 C4B 0.9
IGHV3-11 SERPING1 0.9
IGHV3-11 C1QC 0.9
IGHV3-11 CRP 0.9
IGLL5 SERPING1 0.9
IGLL5 CRP 0.9
IGHV3-11 C1S 0.9
IGHV3-11 C1QA 0.9
IGHV3-11 C4A 0.9
IGHV3-11 C1R 0.9
IGHV3-11 C1QB 0.9
IGLL5 C1S 0.9
C1QA CSF1R 0.9
Gene Ontology Semantic Similarity
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# 714 (C1QC) 712 (C1QA) 715 (C1R) 721 (C4B) 716 (C1S) 720 (C4A) 713 (C1QB) 1436 (CSF1R) 100423062 (IGLL5) 710 (SERPING1) 717 (C2) 7305 (TYROBP) 1401 (CRP)
714 (C1QC) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.10 0.12 0.12 1.00 0.12 0.12
712 (C1QA) 1.00 1.00 0.86 0.84 0.96 0.80 1.00 0.49 0.52 0.56 1.00 0.67 0.54
715 (C1R) 1.00 0.86 1.00 0.77 0.86 0.71 0.86 0.41 0.43 0.46 0.86 0.56 0.63
721 (C4B) 1.00 0.84 0.77 1.00 0.81 0.77 0.84 0.41 0.48 0.49 0.84 0.56 0.51
716 (C1S) 1.00 0.96 0.86 0.81 1.00 0.74 0.96 0.55 0.53 0.61 0.96 0.74 0.57
720 (C4A) 1.00 0.80 0.71 0.77 0.74 1.00 0.80 0.31 0.33 0.35 0.80 0.41 0.46
713 (C1QB) 1.00 1.00 0.86 0.84 0.96 0.80 1.00 0.49 0.52 0.56 1.00 0.67 0.54
1436 (CSF1R) 0.10 0.49 0.41 0.41 0.55 0.31 0.49 1.00 0.42 0.48 0.49 0.60 0.46
100423062 (IGLL5) 0.12 0.52 0.43 0.48 0.53 0.33 0.52 0.42 1.00 0.52 0.52 0.63 0.50
710 (SERPING1) 0.12 0.56 0.46 0.49 0.61 0.35 0.56 0.48 0.52 1.00 0.56 0.67 0.54
717 (C2) 1.00 1.00 0.86 0.84 0.96 0.80 1.00 0.49 0.52 0.56 1.00 0.67 0.54
7305 (TYROBP) 0.12 0.67 0.56 0.56 0.74 0.41 0.67 0.60 0.63 0.67 0.67 1.00 0.62
1401 (CRP) 0.12 0.54 0.63 0.51 0.57 0.46 0.54 0.46 0.50 0.54 0.54 0.62 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
C1QA Bird Kidney - 4000 m Native downregulated -2.33 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
C1QA Human Serum - 2400 m 0.5 hours upregulated 0.068 2-DE Western Europe Germans 0.143 Healthy adults never had ear surgery or problems with pressure equalization 28858246
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT017487 hsa-miR-335-5p Homo sapiens C1QA 712 Homo sapiens Microarray Functional MTI (Weak) 18185580
Gene Ontology
ID GO ID GO Term GO Type
712 GO:0006956 complement activation GOTERM_BP_DIRECT
712 GO:0007267 cell-cell signaling GOTERM_BP_DIRECT
712 GO:0045087 innate immune response GOTERM_BP_DIRECT
712 GO:0004252 serine-type endopeptidase activity GOTERM_MF_DIRECT
712 GO:0006508 proteolysis GOTERM_BP_DIRECT
712 GO:0005515 protein binding GOTERM_MF_DIRECT
712 GO:0006958 complement activation GOTERM_BP_DIRECT
712 GO:0005576 extracellular region GOTERM_CC_DIRECT
712 GO:0010039 response to iron ion GOTERM_BP_DIRECT
712 GO:0005581 collagen trimer GOTERM_CC_DIRECT
712 GO:0005602 complement component C1 complex GOTERM_CC_DIRECT
712 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
712 hsa04610 Complement and coagulation cascades
712 hsa05020 Prion diseases
712 hsa05133 Pertussis
712 hsa05142 Chagas disease
712 hsa05150 Staphylococcus aureus infection
712 hsa05322 Systemic lupus erythematosus
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
C1QA 712 Glomerulonephritis, Membranoproliferative C0017662 Disease or Syndrome 0.3 0.667 0.483 disease
C1QA 712 Membranoproliferative Glomerulonephritis, Type II C0268743 Disease or Syndrome 0.3 0.667 0.483 disease
C1QA 712 Membranoproliferative Glomerulonephritis, Type III C1720821 Disease or Syndrome 0.3 0.667 0.483 disease
C1QA 712 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.667 0.483 disease
C1QA 712 Lupus Erythematosus, Systemic C0024141 Disease or Syndrome 0.56 0.667 0.483 disease
C1QA 712 C1q DEFICIENCY C3150902 Disease or Syndrome 0.4 0.667 0.483 disease
C1QA 712 Exanthema C0015230 Sign or Symptom 0.3 0.667 0.483 phenotype
C1QA 712 Immune Complex Diseases C0020951 Disease or Syndrome 0.3 0.667 0.483 group
C1QA 712 Membranoproliferative Glomerulonephritis, Type I C0268742 Disease or Syndrome 0.3 0.667 0.483 disease
C1QA 712 Libman-Sacks Disease C0242380 Disease or Syndrome 0.3 0.667 0.483 disease
C1QA 712 IGA Glomerulonephritis C0017661 Disease or Syndrome 0.3 0.667 0.483 disease
C1QA 712 SYSTEMIC LUPUS ERYTHEMATOSUS 16 C3280742 Disease or Syndrome 0.3 0.667 0.483 disease
C1QA 712 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.01 0.667 0.483 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
C1QA 712 IMMUNE GLOBULIN None None None