ALTITUDEOMICSDB

Tumor necrosis factor

AltitudeomicsDB

Protein Official symbol	TNF
Aliases	TNF TNFA TNFSF2
Chromosomal Location	6
Length	233
Uniprot ID	P01375
EC number	None
Protein family Information(Pfam)	PF00229;
PDB id	1A8M;1TNF;2AZ5;2E7A;2TUN;2ZJC;2ZPX;3ALQ;3IT8;3L9J;3WD5;4G3Y;4TSV;4TWT;4Y6O;5M2I;5M2J;5M2M;5MU8;5TSW;5UUI;5WUX;5YOY;6OOY;6OOZ;6OP0;6RMJ;
InterPro ID	IPR006053;IPR002959;IPR021184;IPR006052;IPR008983;
dbSNP	rs4645843 rs1800620

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
TNF	TNFRSF1A	0.999
IKBKB	TNF	0.999
BIRC3	TRAF2	0.999
TRAF6	MAP3K7	0.999
TAB2	RIPK1	0.999
JUN	FOS	0.999
MAP3K7	TAB1	0.999
TNF	TNFRSF1B	0.999
TNF	MAP3K7	0.999
RIPK1	TRAF2	0.999
IKBKG	TNF	0.999
IKBKB	NFKBIA	0.999
TNF	RIPK1	0.999
TNF	TAB2	0.999
IKBKG	IKBKB	0.999
NFKB1	NFKBIA	0.999
TRAF6	TAB2	0.999
MAP3K7	TAB2	0.999
TNF	TRADD	0.999
TNF	TRAF2	0.999
IKBKG	RIPK1	0.999
CASP8	FADD	0.999
TRADD	RIPK1	0.999
CHUK	NFKBIA	0.998
IKBKG	CHUK	0.998
CASP8	TRADD	0.998
TAB2	TAB1	0.998
CASP8	RIPK1	0.998
RELA	NFKBIA	0.998
BIRC2	TRAF2	0.997
IL6	STAT3	0.997
IL10	TNF	0.997
IKBKB	RELA	0.997
IL10	IL6	0.997
IKBKG	NFKBIA	0.997
LTA	TNFRSF1A	0.997
IKBKG	MAP3K7	0.997
TRADD	TRAF2	0.997
IL10	IL1B	0.996
TRADD	FADD	0.996
IKBKG	CYLD	0.996
TRADD	TNFRSF1A	0.996
IL6	IL4	0.996
LTA	LTBR	0.996
IKBKG	RELA	0.996
TRAF6	TAB1	0.996
BIRC2	CASP8	0.996
BIRC2	TNF	0.996
IL10	CXCL8	0.996
JUN	MAPK14	0.995
TRAF1	BIRC3	0.995
IKBKG	RNF31	0.995
IL10	CCL2	0.995
RELA	CHUK	0.995
IKBKB	NFKB1	0.995
MAPK14	TAB1	0.995
IL10	STAT3	0.995
TNF	VCAM1	0.994
TRAF2	TNFRSF1A	0.994
CASP8	TRAF2	0.994
TNFRSF1B	TNFRSF1A	0.994
FADD	RIPK1	0.994
IKBKG	TRAF6	0.994
FADD	TNFRSF1A	0.993
TRAF1	CASP8	0.993
RELA	EP300	0.993
CASP8	BIRC3	0.993
CXCL8	IL1B	0.992
IKBKG	TAB2	0.992
TNF	NFKBIA	0.992
CXCL8	IL4	0.992
MYC	JUN	0.992
TNF	IL13	0.992
RELA	NFKB1	0.992
IKBKG	TRAF2	0.992
TNF	IL4	0.992
IL4	CCL2	0.991
IKBKB	MAP3K7	0.991
IKBKB	CHUK	0.991
IKBKG	TAB1	0.991
CYLD	RNF31	0.991
IL1B	IL4	0.991
MYC	STAT3	0.99
TRAF6	CYLD	0.99
PPARG	EP300	0.99
BIRC2	RIPK1	0.99
TNF	RELA	0.99
STAT1	IFNG	0.989
TNF	IL1B	0.989
BIRC2	TRAF1	0.989
CYLD	RIPK1	0.989
CASP8	TNFRSF1A	0.989
MAP3K7	BIRC3	0.988
FOS	STAT3	0.988
FADD	TRAF2	0.988
IL6	IL13	0.988
RELA	CXCL8	0.987
IL13	VCAM1	0.987
TNFAIP3	TNF	0.987
IKBKB	TNFRSF1A	0.986
BIRC3	RIPK1	0.986
TNF	JUN	0.986
TNF	CASP8	0.986
PSMC3	TNF	0.986
IKBKG	BIRC2	0.985
IKBKB	BIRC3	0.985
CHUK	NFKB1	0.985
RIPK1	TNFRSF1A	0.985
IL6	CXCL8	0.985
IL6	JUN	0.984
TNF	NOS2	0.984
TNF	IL6	0.984
TNF	BIRC3	0.984
MAP3K5	TRAF2	0.984
BIRC2	MAP3K7	0.984
TNF	MAPK14	0.984
IL6	IL1B	0.984
TNFAIP3	TRAF1	0.983
IL6	STAT1	0.983
CXCL8	STAT3	0.983
TRAF6	TRAF2	0.983
TNFRSF1B	TRAF1	0.983
IL6	RELA	0.983
CXCL8	IL13	0.983
TNF	PPARG	0.982
IL6	CCL2	0.982
STAT1	MAPK14	0.982
IL6	FOS	0.982
TNF	TNFSF13B	0.982
RELA	MAP3K7	0.981
TRAF1	TNFRSF1A	0.981
IKBKB	TRAF2	0.981
TNF	TRAF1	0.981
BIRC2	TNFRSF1A	0.981
TNF	FADD	0.981
STAT3	CCL2	0.981
CHUK	TRAF2	0.981
TNF	FOS	0.981
IL13	CCL2	0.981
TNFRSF1B	TRAF2	0.98
STAT3	IL4	0.98
RELA	JUN	0.98
RELA	BIRC3	0.98
CXCL8	CCL2	0.98
IL10	TNFRSF1B	0.98
IKBKG	NFKB1	0.98
MYC	EP300	0.979
IKBKG	BIRC3	0.979
IKBKG	TNFRSF1A	0.979
JUN	EP300	0.979
TNF	ADAM17	0.979
BIRC2	TRADD	0.979
JUN	MAPK11	0.979
TRAF1	TRADD	0.979
TNF	CD40LG	0.979
STAT1	EP300	0.978
IL1B	MAPK14	0.978
JUN	CCL2	0.978
FOS	MAPK14	0.978
IL13	STAT3	0.978
MAPK14	NFKBIA	0.977
TNFAIP3	TRAF6	0.977
TRAF1	TRAF2	0.977
LTA	TNFRSF1B	0.977
STAT3	EP300	0.976
CHUK	TAB2	0.976
TNF	STAT3	0.976
TRAF6	IL1B	0.976
IL1B	NFKB1	0.976
MYC	TNF	0.976
BIRC3	TNFRSF1A	0.976
TRAF6	TNFRSF1A	0.976
TRAF6	MAP3K5	0.975
TNFAIP3	BIRC3	0.975
TRAF6	IKBKB	0.975
TNF	IFNG	0.975
BIRC2	FADD	0.974
CXCL8	MAPK14	0.974
TNFSF13B	CD40LG	0.974
TRAF1	MAP3K5	0.974
IKBKB	TAB2	0.974
IKBKG	TNFAIP3	0.973
MAPK11	TAB1	0.973
RNF31	TNFRSF1A	0.973
TRAF6	CHUK	0.973
TNF	CXCL8	0.973
TNF	LTBR	0.973
TRAF6	RIPK1	0.972
TNF	STAT1	0.972
TNFAIP3	TNFRSF1A	0.972
TRAF6	TNF	0.972
CYLD	TRAF2	0.972
BIRC2	TAB2	0.972
IL10	IL4	0.972
IL13	IL1B	0.972
MYC	RELA	0.972
STAT1	STAT3	0.972
TNF	CHUK	0.972
STAT3	MAPK14	0.971
BIRC2	RNF31	0.971
TNF	CCL2	0.971
TNFRSF1B	TRADD	0.971
IL13	IL4	0.971
JUN	CXCL8	0.971
CHUK	TNFRSF1A	0.971
MAP3K7	NFKBIA	0.971
IKBKG	FADD	0.971
IKBKB	TAB1	0.971
TNF	MAP3K5	0.971
FADD	BIRC3	0.971
TRAF6	TRADD	0.97
TRAF6	MAPK14	0.97
CYLD	TNFRSF1A	0.97
FOS	EP300	0.97
TNFRSF1B	ADAM17	0.97
TRAF1	RIPK1	0.97
BIRC2	RELA	0.97
FOS	CCL2	0.97
TNFAIP3	RIPK1	0.969
IKBKG	CASP8	0.969
JUN	NFKBIA	0.968
RELA	FOS	0.968
TNF	NFKB1	0.968
IKBKG	TRADD	0.968
FOS	PPARG	0.968
TAB2	TRAF2	0.968
TAB2	NFKB1	0.968
PSMC3	TRAF2	0.967
MAP3K7	TNFRSF1A	0.966
CASP8	IL1B	0.966
BIRC2	CYLD	0.966
TNF	CYLD	0.966
TNF	CAV1	0.965
TNF	TAB1	0.965
IL10	TNFRSF1A	0.965
TRAF2	TAB1	0.965
RNF31	RIPK1	0.965
STAT3	IL1B	0.965
CYLD	MAP3K7	0.965
TNF	RNF31	0.964
TRAF1	CD40LG	0.964
TNF	MAPK11	0.964
IKBKB	CASP8	0.963
CYLD	TAB2	0.963
IL6	NFKB1	0.963
CHUK	MAP3K7	0.963
TNFAIP3	IKBKB	0.963
JUN	IL1B	0.963
TAB2	TRADD	0.962
TRADD	BIRC3	0.962
RIPK1	NFKB1	0.962
STAT1	IL13	0.962
IL4	MAPK14	0.962
RELA	PPARG	0.962
CHUK	TRADD	0.962
TRAF6	RELA	0.961
TNF	EP300	0.961
STAT1	TNFRSF1A	0.961
BIRC3	TAB1	0.961
CHUK	CASP8	0.961
BIRC2	IKBKB	0.961
LTA	TNF	0.961
MAP3K7	NFKB1	0.96
EP300	NFKB1	0.96
RELA	TNFRSF1A	0.96
TNFAIP3	CHUK	0.96
CXCL8	EP300	0.959
RNF31	TRAF2	0.959
RELA	IFNG	0.959
BIRC2	CHUK	0.959
BIRC2	LTBR	0.959
PPARG	NFKB1	0.958
TRAF6	NFKBIA	0.958
TRAF6	NFKB1	0.958
CYLD	STAT1	0.958
CXCL8	NFKB1	0.958
RNF31	BIRC3	0.958
TRAF1	NFKBIA	0.957
MAP3K7	TRAF2	0.957
TNFAIP3	TRAF2	0.957
JUN	PPARG	0.956
CYLD	TRADD	0.956
EP300	NFKBIA	0.956
JUN	NOS2	0.956
TNFAIP3	BIRC2	0.956
CYLD	FADD	0.956
MAP3K5	CASP8	0.956
TNFAIP3	RNF31	0.956
CD40LG	TRAF2	0.956
NFKBIA	TNFRSF1A	0.955
BIRC2	TAB1	0.955
TAB2	BIRC3	0.955
TRADD	RNF31	0.955
TRADD	TAB1	0.955
NOS2	STAT3	0.955
BIRC2	CD40LG	0.955
TAB2	TNFRSF1A	0.954
RELA	IL1B	0.954
CHUK	TAB1	0.954
STAT1	FADD	0.954
TRAF6	CD40LG	0.954
IL10	IL13	0.954
STAT3	TNFRSF1A	0.954
TRAF2	LTBR	0.954
JUN	IL4	0.954
RIPK1	TAB1	0.953
TRAF1	NFKB1	0.953
NOS2	NFKBIA	0.953
TNFRSF1B	RIPK1	0.953
RELA	TRAF1	0.953
RELA	CASP8	0.953
CYLD	BIRC3	0.952
TRAF1	FADD	0.952
NFKB1	TNFRSF1A	0.952
TRAF6	FADD	0.952
STAT1	MAPK11	0.951
RELA	NOS2	0.951
STAT1	TRADD	0.951
TNFRSF1B	CD40LG	0.951
RELA	TRADD	0.951
MAP3K7	MAPK14	0.95
IKBKB	RIPK1	0.95
MAP3K5	FADD	0.95
CAV1	TNFRSF1A	0.95
CASP8	NFKB1	0.95
TAB2	MAPK14	0.95
EP300	MAPK14	0.95
TNFAIP3	FADD	0.95
TAB1	TNFRSF1A	0.95
IL1B	CCL2	0.95
VCAM1	STAT3	0.949
JUN	IFNG	0.949
MYC	MAPK14	0.949
MAPK14	NFKB1	0.948
RELA	RIPK1	0.948
IKBKB	TRADD	0.948
CD40LG	BIRC3	0.948
RELA	MAPK14	0.948
MAP3K5	TNFRSF1A	0.948
LTA	CD40LG	0.948
RELA	TRAF2	0.947
MAP3K5	TRADD	0.947
TNFRSF1B	TNFSF13B	0.947
CHUK	BIRC3	0.947
TRAF2	NFKBIA	0.946
IL10	IFNG	0.946
RELA	TAB2	0.946
MAP3K7	RIPK1	0.946
STAT1	VCAM1	0.946
IKBKB	CYLD	0.945
RELA	TAB1	0.945
RELA	CD40LG	0.945
TNFRSF1B	BIRC3	0.944
MAPK11	MAPK14	0.944
TRAF6	TNFSF13B	0.944
TNFAIP3	TAB2	0.944
TRADD	NFKB1	0.944
CYLD	CHUK	0.944
CHUK	RIPK1	0.943
CYLD	TAB1	0.943
BIRC2	TNFRSF1B	0.943
MYC	NFKBIA	0.943
IKBKB	RNF31	0.943
RELA	IL4	0.942
NFKBIA	TAB1	0.942
CHUK	FADD	0.942
BIRC2	TNFSF13B	0.942
TNFSF13B	LTBR	0.942
MAPK11	IL1B	0.942
TRADD	CAV1	0.941
TAB2	NFKBIA	0.941
TNFRSF1B	STAT3	0.941
TNFAIP3	TRADD	0.941
VCAM1	CCL2	0.94
IKBKB	FADD	0.94
NFKB1	TAB1	0.939
IL6	IFNG	0.939
RELA	CCL2	0.939
CD40LG	NFKB1	0.938
CAV1	TRAF2	0.938
BIRC3	LTBR	0.938
CHUK	RNF31	0.938
CD40LG	LTBR	0.937
TNFAIP3	MAP3K7	0.937
BIRC2	BIRC3	0.937
RIPK1	NFKBIA	0.937
TNFSF13B	BIRC3	0.936
PSMC3	NFKB1	0.935
LTA	RIPK1	0.935
STAT1	RIPK1	0.934
TNFSF13B	TRAF2	0.933
TRAF2	NFKB1	0.933
PSMC3	BIRC2	0.932
BIRC2	LTA	0.932
TRAF2	MAPK14	0.932
MYC	MAPK11	0.931
CD40LG	NFKBIA	0.931
TRAF6	MAPK11	0.931
CYLD	CASP8	0.931
MAP3K7	TRADD	0.931
MAP3K5	RIPK1	0.929
LTA	TRAF1	0.928
CD40LG	MAPK14	0.927
TNFAIP3	NFKBIA	0.926
MAPK11	FOS	0.926
BIRC3	NFKB1	0.926
PSMC3	NFKBIA	0.926
LTA	TNFSF13B	0.925
MAP3K5	BIRC3	0.924
TAB2	MAPK11	0.924
TRAF6	ADAM17	0.923
MAP3K7	MAPK11	0.923
IL1B	EP300	0.923
JUN	STAT3	0.921
IL4	IFNG	0.921
RIPK1	MAPK14	0.92
PPARG	TNFRSF1A	0.92
TNFRSF1B	LTBR	0.919
LTA	TRAF2	0.919
STAT1	TRAF2	0.918
MYC	NOS2	0.918
TNFAIP3	TAB1	0.917
LTA	BIRC3	0.917
IL10	MAP3K5	0.917
MYC	FOS	0.915
CD40LG	IL4	0.914
MAPK11	CXCL8	0.914
MAPK11	TRAF2	0.91
CAV1	RIPK1	0.904
CD40LG	MAPK11	0.904
PSMC3	LTA	0.904
PSMC3	BIRC3	0.903
PSMC3	RELA	0.902
PSMC3	LTBR	0.902
IL1B	IFNG	0.902
PSMC3	TNFRSF1B	0.9
PSMC3	TNFSF13B	0.9
PSMC3	CD40LG	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	23118 (TAB2)	7189 (TRAF6)	4790 (NFKB1)	7124 (TNF)	8517 (IKBKG)	6885 (MAP3K7)	8717 (TRADD)	3551 (IKBKB)	330 (BIRC3)	3725 (JUN)	841 (CASP8)	8737 (RIPK1)	5970 (RELA)	1147 (CHUK)	3569 (IL6)	329 (BIRC2)	3586 (IL10)	4049 (LTA)	7185 (TRAF1)	1432 (MAPK14)	8772 (FADD)	7186 (TRAF2)	7133 (TNFRSF1B)	4609 (MYC)	3576 (CXCL8)	3565 (IL4)	1540 (CYLD)	3553 (IL1B)	5468 (PPARG)	6772 (STAT1)	2353 (FOS)	7128 (TNFAIP3)	3596 (IL13)	5702 (PSMC3)	4217 (MAP3K5)	6774 (STAT3)	10673 (TNFSF13B)	55072 (RNF31)	5600 (MAPK11)	2033 (EP300)	959 (CD40LG)	4792 (NFKBIA)	4843 (NOS2)	10454 (TAB1)	857 (CAV1)	7412 (VCAM1)	7132 (TNFRSF1A)	4055 (LTBR)	6347 (CCL2)	6868 (ADAM17)
23118 (TAB2)	1.00	0.65	0.48	0.69	0.78	0.57	0.76	0.57	0.52	0.45	0.49	0.59	0.49	0.62	0.74	0.58	0.74	0.82	0.74	0.55	0.74	0.62	0.65	0.55	0.69	0.75	0.52	0.66	0.53	0.55	0.56	0.69	1.00	0.61	0.50	0.50	0.84	0.72	0.56	0.46	0.77	0.74	0.46	0.69	0.62	0.54	0.67	0.68	0.52	0.58
7189 (TRAF6)	0.65	1.00	0.55	0.72	0.69	0.65	0.74	0.70	0.70	0.54	0.61	0.70	0.62	0.65	0.66	0.69	0.66	0.82	0.82	0.67	0.72	0.88	0.68	0.58	0.64	0.66	0.66	0.56	0.58	0.67	0.58	0.71	1.00	0.64	0.59	0.61	0.68	0.78	0.62	0.56	0.68	0.77	0.54	0.63	0.71	0.52	0.63	0.71	0.54	0.61
4790 (NFKB1)	0.48	0.55	1.00	0.70	0.56	0.48	0.54	0.50	0.43	0.80	0.45	0.51	0.88	0.52	0.51	0.47	0.51	0.82	0.54	0.47	0.55	0.54	0.47	0.82	0.48	0.49	0.45	0.41	0.77	0.77	0.82	0.50	1.00	0.50	0.45	0.80	0.50	0.48	0.44	0.60	0.48	0.58	0.47	0.46	0.54	0.38	0.47	0.51	0.38	0.47
7124 (TNF)	0.69	0.72	0.70	1.00	0.66	0.62	0.74	0.59	0.56	0.63	0.54	0.65	0.62	0.63	0.76	0.58	0.76	0.84	0.82	0.58	0.85	0.72	0.64	0.70	0.68	0.70	0.55	0.69	0.64	0.74	0.70	0.67	1.00	0.65	0.54	0.65	0.76	0.65	0.58	0.57	0.75	0.74	0.54	0.65	0.66	0.53	0.65	0.69	0.58	0.60
8517 (IKBKG)	0.78	0.69	0.56	0.66	1.00	0.61	0.71	0.69	0.57	0.55	0.61	0.74	0.58	0.73	0.67	0.61	0.67	0.82	0.75	0.61	0.70	0.73	0.72	0.57	0.64	0.67	0.56	0.61	0.60	0.62	0.62	0.69	1.00	0.62	0.62	0.63	0.69	0.75	0.60	0.51	0.67	0.74	0.55	0.64	0.64	0.51	0.66	0.74	0.50	0.61
6885 (MAP3K7)	0.57	0.65	0.48	0.62	0.61	1.00	0.65	0.89	0.60	0.46	0.53	0.83	0.49	0.89	0.59	0.61	0.59	0.82	0.64	0.82	0.65	0.63	0.53	0.51	0.55	0.58	0.50	0.50	0.52	0.54	0.51	0.61	1.00	0.56	0.82	0.51	0.60	0.62	0.91	0.51	0.57	0.65	0.45	0.53	0.60	0.46	0.54	0.60	0.74	0.53
8717 (TRADD)	0.76	0.74	0.54	0.74	0.71	0.65	1.00	0.65	0.59	0.51	0.56	0.70	0.55	0.66	0.74	0.60	0.74	0.82	0.78	0.63	0.78	0.70	0.69	0.59	0.71	0.75	0.61	0.68	0.57	0.63	0.60	0.66	1.00	0.69	0.57	0.58	0.80	0.70	0.63	0.50	0.76	0.79	0.52	0.71	0.68	0.57	0.70	0.75	0.55	0.63
3551 (IKBKB)	0.57	0.70	0.50	0.59	0.69	0.89	0.65	1.00	0.60	0.50	0.52	0.79	0.54	0.96	0.59	0.60	0.59	0.82	0.61	0.81	0.62	0.65	0.54	0.51	0.55	0.58	0.56	0.49	0.54	0.56	0.55	0.59	1.00	0.54	0.80	0.57	0.59	0.61	0.83	0.51	0.57	0.63	0.50	0.53	0.62	0.45	0.55	0.57	0.69	0.53
330 (BIRC3)	0.52	0.70	0.43	0.56	0.57	0.60	0.59	0.60	1.00	0.43	0.52	0.60	0.46	0.61	0.56	0.83	0.56	0.82	0.58	0.57	0.60	0.68	0.47	0.48	0.50	0.54	0.50	0.47	0.49	0.48	0.47	0.70	1.00	0.52	0.53	0.46	0.56	0.76	0.54	0.57	0.52	0.60	0.43	0.53	0.59	0.45	0.48	0.51	0.51	0.52
3725 (JUN)	0.45	0.54	0.80	0.63	0.55	0.46	0.51	0.50	0.43	1.00	0.45	0.49	0.83	0.51	0.47	0.52	0.47	0.82	0.51	0.47	0.52	0.54	0.45	0.79	0.45	0.46	0.43	0.38	0.76	0.76	0.84	0.49	1.00	0.47	0.46	0.80	0.46	0.46	0.42	0.63	0.45	0.56	0.49	0.48	0.57	0.36	0.45	0.48	0.36	0.45
841 (CASP8)	0.49	0.61	0.45	0.54	0.61	0.53	0.56	0.52	0.52	0.45	1.00	0.59	0.50	0.54	0.51	0.54	0.51	0.82	0.60	0.49	0.60	0.61	0.53	0.47	0.48	0.50	0.66	0.45	0.51	0.50	0.47	0.67	1.00	0.56	0.48	0.50	0.51	0.57	0.45	0.48	0.49	0.61	0.45	0.46	0.56	0.42	0.48	0.58	0.41	0.69
8737 (RIPK1)	0.59	0.70	0.51	0.65	0.74	0.83	0.70	0.79	0.60	0.49	0.59	1.00	0.54	0.78	0.61	0.60	0.61	0.82	0.73	0.75	0.69	0.76	0.65	0.57	0.58	0.61	0.52	0.55	0.56	0.59	0.54	0.61	1.00	0.58	0.74	0.59	0.63	0.68	0.78	0.52	0.63	0.70	0.49	0.57	0.62	0.50	0.59	0.69	0.67	0.57
5970 (RELA)	0.49	0.62	0.88	0.62	0.58	0.49	0.55	0.54	0.46	0.83	0.50	0.54	1.00	0.53	0.51	0.50	0.51	0.82	0.55	0.51	0.54	0.58	0.51	0.83	0.49	0.50	0.49	0.41	0.77	0.79	0.76	0.51	1.00	0.51	0.49	0.85	0.50	0.52	0.47	0.61	0.49	0.61	0.52	0.48	0.57	0.39	0.49	0.54	0.39	0.48
1147 (CHUK)	0.62	0.65	0.52	0.63	0.73	0.89	0.66	0.96	0.61	0.51	0.54	0.78	0.53	1.00	0.63	0.61	0.63	0.82	0.65	0.77	0.66	0.63	0.58	0.53	0.59	0.62	0.52	0.53	0.55	0.57	0.57	0.61	1.00	0.57	0.79	0.55	0.65	0.64	0.83	0.51	0.62	0.66	0.51	0.57	0.60	0.48	0.59	0.61	0.70	0.55
3569 (IL6)	0.74	0.66	0.51	0.76	0.67	0.59	0.74	0.59	0.56	0.47	0.51	0.61	0.51	0.63	1.00	0.58	0.94	0.84	0.74	0.57	0.75	0.64	0.66	0.57	0.72	0.89	0.55	0.84	0.54	0.57	0.58	0.61	1.00	0.63	0.53	0.52	0.86	0.67	0.60	0.48	0.75	0.73	0.52	0.69	0.65	0.55	0.68	0.68	0.66	0.69
329 (BIRC2)	0.58	0.69	0.47	0.58	0.61	0.61	0.60	0.60	0.83	0.52	0.54	0.60	0.50	0.61	0.58	1.00	0.58	0.82	0.59	0.58	0.60	0.66	0.53	0.51	0.55	0.57	0.62	0.48	0.59	0.52	0.53	0.71	1.00	0.55	0.59	0.50	0.58	0.74	0.57	0.63	0.56	0.61	0.49	0.57	0.60	0.47	0.54	0.55	0.50	0.55
3586 (IL10)	0.74	0.66	0.51	0.76	0.67	0.59	0.74	0.59	0.56	0.47	0.51	0.61	0.51	0.63	0.94	0.58	1.00	0.84	0.74	0.57	0.75	0.64	0.66	0.57	0.72	0.89	0.55	0.84	0.54	0.57	0.58	0.61	1.00	0.63	0.53	0.52	0.86	0.67	0.60	0.48	0.75	0.73	0.52	0.69	0.65	0.55	0.68	0.68	0.66	0.65
4049 (LTA)	0.82	0.82	0.82	0.84	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.84	0.82	0.84	1.00	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.84	0.82	0.84	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.82	1.00	0.82	0.82	0.82	0.82	0.82	1.00	0.82	1.00	0.66	0.82	0.82	1.00	0.84
7185 (TRAF1)	0.74	0.82	0.54	0.82	0.75	0.64	0.78	0.61	0.58	0.51	0.60	0.73	0.55	0.65	0.74	0.59	0.74	0.82	1.00	0.61	0.82	0.81	0.77	0.58	0.70	0.74	0.57	0.65	0.56	0.68	0.59	0.65	1.00	0.68	0.55	0.55	0.80	0.77	0.61	0.49	0.80	0.84	0.52	0.69	0.67	0.55	0.68	0.82	0.56	0.62
1432 (MAPK14)	0.55	0.67	0.47	0.58	0.61	0.82	0.63	0.81	0.57	0.47	0.49	0.75	0.51	0.77	0.57	0.58	0.57	0.82	0.61	1.00	0.62	0.69	0.54	0.52	0.54	0.56	0.52	0.48	0.54	0.54	0.51	0.58	1.00	0.52	0.78	0.56	0.58	0.60	0.84	0.50	0.55	0.67	0.45	0.52	0.63	0.44	0.54	0.56	0.65	0.52
8772 (FADD)	0.74	0.72	0.55	0.85	0.70	0.65	0.78	0.62	0.60	0.52	0.60	0.69	0.54	0.66	0.75	0.60	0.75	0.82	0.82	0.62	1.00	0.74	0.68	0.59	0.72	0.76	0.58	0.69	0.57	0.67	0.60	0.71	1.00	0.68	0.58	0.56	0.79	0.69	0.63	0.50	0.82	0.78	0.53	0.70	0.68	0.56	0.69	0.73	0.58	0.64
7186 (TRAF2)	0.62	0.88	0.54	0.72	0.73	0.63	0.70	0.65	0.68	0.54	0.61	0.76	0.58	0.63	0.64	0.66	0.64	0.82	0.81	0.69	0.74	1.00	0.67	0.56	0.61	0.64	0.61	0.55	0.59	0.67	0.57	0.70	1.00	0.61	0.61	0.66	0.66	0.76	0.60	0.55	0.71	0.75	0.53	0.61	0.71	0.50	0.62	0.70	0.54	0.59
7133 (TNFRSF1B)	0.65	0.68	0.47	0.64	0.72	0.53	0.69	0.54	0.47	0.45	0.53	0.65	0.51	0.58	0.66	0.53	0.66	0.82	0.77	0.54	0.68	0.67	1.00	0.53	0.61	0.66	0.49	0.57	0.55	0.53	0.53	0.56	1.00	0.56	0.48	0.50	0.71	0.72	0.51	0.45	0.65	0.76	0.44	0.59	0.61	0.48	0.88	0.97	0.47	0.54
4609 (MYC)	0.55	0.58	0.82	0.70	0.57	0.51	0.59	0.51	0.48	0.79	0.47	0.57	0.83	0.53	0.57	0.51	0.57	0.82	0.58	0.52	0.59	0.56	0.53	1.00	0.54	0.56	0.49	0.47	0.74	0.78	0.80	0.53	1.00	0.54	0.48	0.84	0.58	0.54	0.49	0.62	0.55	0.65	0.51	0.53	0.57	0.46	0.53	0.55	0.43	0.53
3576 (CXCL8)	0.69	0.64	0.48	0.68	0.64	0.55	0.71	0.55	0.50	0.45	0.48	0.58	0.49	0.59	0.72	0.55	0.72	0.82	0.70	0.54	0.72	0.61	0.61	0.54	1.00	0.70	0.51	0.67	0.52	0.54	0.54	0.58	1.00	0.58	0.49	0.49	0.78	0.63	0.53	0.46	0.70	0.70	0.47	0.62	0.62	0.50	0.62	0.64	0.73	0.57
3565 (IL4)	0.75	0.66	0.49	0.70	0.67	0.58	0.75	0.58	0.54	0.46	0.50	0.61	0.50	0.62	0.89	0.57	0.89	0.84	0.74	0.56	0.76	0.64	0.66	0.56	0.70	1.00	0.54	0.77	0.53	0.56	0.57	0.60	1.00	0.62	0.51	0.51	0.87	0.67	0.58	0.47	0.77	0.73	0.50	0.69	0.64	0.55	0.67	0.68	0.61	0.65
1540 (CYLD)	0.52	0.66	0.45	0.55	0.56	0.50	0.61	0.56	0.50	0.43	0.66	0.52	0.49	0.52	0.55	0.62	0.55	0.82	0.57	0.52	0.58	0.61	0.49	0.49	0.51	0.54	1.00	0.46	0.54	0.50	0.48	0.78	1.00	0.55	0.50	0.50	0.55	0.54	0.46	0.47	0.52	0.60	0.45	0.49	0.60	0.43	0.50	0.52	0.42	0.61
3553 (IL1B)	0.66	0.56	0.41	0.69	0.61	0.50	0.68	0.49	0.47	0.38	0.45	0.55	0.41	0.53	0.84	0.48	0.84	0.84	0.65	0.48	0.69	0.55	0.57	0.47	0.67	0.77	0.46	1.00	0.46	0.49	0.48	0.51	0.82	0.53	0.48	0.42	0.79	0.58	0.51	0.40	0.69	0.62	0.44	0.61	0.55	0.49	0.59	0.59	0.61	0.62
5468 (PPARG)	0.53	0.58	0.77	0.64	0.60	0.52	0.57	0.54	0.49	0.76	0.51	0.56	0.77	0.55	0.54	0.59	0.54	0.82	0.56	0.54	0.57	0.59	0.55	0.74	0.52	0.53	0.54	0.46	1.00	0.72	0.72	0.55	1.00	0.53	0.53	0.76	0.54	0.53	0.50	0.68	0.53	0.62	0.54	0.51	0.58	0.42	0.55	0.57	0.42	0.51
6772 (STAT1)	0.55	0.67	0.77	0.74	0.62	0.54	0.63	0.56	0.48	0.76	0.50	0.59	0.79	0.57	0.57	0.52	0.57	0.82	0.68	0.54	0.67	0.67	0.53	0.78	0.54	0.56	0.50	0.49	0.72	1.00	0.74	0.57	1.00	0.55	0.53	0.79	0.59	0.55	0.49	0.58	0.58	0.65	0.54	0.53	0.63	0.45	0.53	0.58	0.46	0.52
2353 (FOS)	0.56	0.58	0.82	0.70	0.62	0.51	0.60	0.55	0.47	0.84	0.47	0.54	0.76	0.57	0.58	0.53	0.58	0.82	0.59	0.51	0.60	0.57	0.53	0.80	0.54	0.57	0.48	0.48	0.72	0.74	1.00	0.53	1.00	0.54	0.47	0.74	0.58	0.54	0.48	0.61	0.56	0.64	0.47	0.53	0.57	0.43	0.53	0.55	0.43	0.52
7128 (TNFAIP3)	0.69	0.71	0.50	0.67	0.69	0.61	0.66	0.59	0.70	0.49	0.67	0.61	0.51	0.61	0.61	0.71	0.61	0.82	0.65	0.58	0.71	0.70	0.56	0.53	0.58	0.60	0.78	0.51	0.55	0.57	0.53	1.00	1.00	0.62	0.55	0.52	0.62	0.78	0.56	0.54	0.60	0.67	0.49	0.57	0.62	0.49	0.57	0.61	0.50	0.63
3596 (IL13)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	0.82	1.00
5702 (PSMC3)	0.61	0.64	0.50	0.65	0.62	0.56	0.69	0.54	0.52	0.47	0.56	0.58	0.51	0.57	0.63	0.55	0.63	0.82	0.68	0.52	0.68	0.61	0.56	0.54	0.58	0.62	0.55	0.53	0.53	0.55	0.54	0.62	1.00	1.00	0.49	0.52	0.65	0.59	0.50	0.47	0.61	0.70	0.46	0.57	0.61	0.47	0.57	0.63	0.46	0.57
4217 (MAP3K5)	0.50	0.59	0.45	0.54	0.62	0.82	0.57	0.80	0.53	0.46	0.48	0.74	0.49	0.79	0.53	0.59	0.53	0.82	0.55	0.78	0.58	0.61	0.48	0.48	0.49	0.51	0.50	0.48	0.53	0.53	0.47	0.55	1.00	0.49	1.00	0.53	0.52	0.55	0.76	0.49	0.50	0.58	0.53	0.47	0.56	0.40	0.48	0.51	0.63	0.50
6774 (STAT3)	0.50	0.61	0.80	0.65	0.63	0.51	0.58	0.57	0.46	0.80	0.50	0.59	0.85	0.55	0.52	0.50	0.52	0.82	0.55	0.56	0.56	0.66	0.50	0.84	0.49	0.51	0.50	0.42	0.76	0.79	0.74	0.52	1.00	0.52	0.53	1.00	0.51	0.50	0.48	0.59	0.50	0.60	0.52	0.49	0.59	0.40	0.51	0.54	0.40	0.49
10673 (TNFSF13B)	0.84	0.68	0.50	0.76	0.69	0.60	0.80	0.59	0.56	0.46	0.51	0.63	0.50	0.65	0.86	0.58	0.86	1.00	0.80	0.58	0.79	0.66	0.71	0.58	0.78	0.87	0.55	0.79	0.54	0.59	0.58	0.62	1.00	0.65	0.52	0.51	1.00	0.72	0.61	0.49	0.87	0.77	0.51	0.76	0.67	0.61	0.73	0.73	0.68	0.66
55072 (RNF31)	0.72	0.78	0.48	0.65	0.75	0.62	0.70	0.61	0.76	0.46	0.57	0.68	0.52	0.64	0.67	0.74	0.67	0.82	0.77	0.60	0.69	0.76	0.72	0.54	0.63	0.67	0.54	0.58	0.53	0.55	0.54	0.78	1.00	0.59	0.55	0.50	0.72	1.00	0.60	0.53	0.67	0.76	0.47	0.61	0.61	0.52	0.61	0.73	0.54	0.58
5600 (MAPK11)	0.56	0.62	0.44	0.58	0.60	0.91	0.63	0.83	0.54	0.42	0.45	0.78	0.47	0.83	0.60	0.57	0.60	0.82	0.61	0.84	0.63	0.60	0.51	0.49	0.53	0.58	0.46	0.51	0.50	0.49	0.48	0.56	1.00	0.50	0.76	0.48	0.61	0.60	1.00	0.48	0.56	0.63	0.41	0.49	0.57	0.43	0.52	0.55	0.71	0.50
2033 (EP300)	0.46	0.56	0.60	0.57	0.51	0.51	0.50	0.51	0.57	0.63	0.48	0.52	0.61	0.51	0.48	0.63	0.48	0.82	0.49	0.50	0.50	0.55	0.45	0.62	0.46	0.47	0.47	0.40	0.68	0.58	0.61	0.54	1.00	0.47	0.49	0.59	0.49	0.53	0.48	1.00	0.46	0.54	0.48	0.45	0.52	0.39	0.46	0.47	0.44	0.47
959 (CD40LG)	0.77	0.68	0.48	0.75	0.67	0.57	0.76	0.57	0.52	0.45	0.49	0.63	0.49	0.62	0.75	0.56	0.75	0.82	0.80	0.55	0.82	0.71	0.65	0.55	0.70	0.77	0.52	0.69	0.53	0.58	0.56	0.60	1.00	0.61	0.50	0.50	0.87	0.67	0.56	0.46	1.00	0.74	0.47	0.69	0.63	0.54	0.67	0.68	0.56	0.59
4792 (NFKBIA)	0.74	0.77	0.58	0.74	0.74	0.65	0.79	0.63	0.60	0.56	0.61	0.70	0.61	0.66	0.73	0.61	0.73	0.82	0.84	0.67	0.78	0.75	0.76	0.65	0.70	0.73	0.60	0.62	0.62	0.65	0.64	0.67	1.00	0.70	0.58	0.60	0.77	0.76	0.63	0.54	0.74	1.00	0.54	0.70	0.70	0.56	0.69	0.80	0.54	0.63
4843 (NOS2)	0.46	0.54	0.47	0.54	0.55	0.45	0.52	0.50	0.43	0.49	0.45	0.49	0.52	0.51	0.52	0.49	0.52	1.00	0.52	0.45	0.53	0.53	0.44	0.51	0.47	0.50	0.45	0.44	0.54	0.54	0.47	0.49	1.00	0.46	0.53	0.52	0.51	0.47	0.41	0.48	0.47	0.54	1.00	0.43	0.55	0.41	0.45	0.47	0.42	0.48
10454 (TAB1)	0.69	0.63	0.46	0.65	0.64	0.53	0.71	0.53	0.53	0.48	0.46	0.57	0.48	0.57	0.69	0.57	0.69	0.82	0.69	0.52	0.70	0.61	0.59	0.53	0.62	0.69	0.49	0.61	0.51	0.53	0.53	0.57	1.00	0.57	0.47	0.49	0.76	0.61	0.49	0.45	0.69	0.70	0.43	1.00	0.67	0.49	0.61	0.63	0.48	0.55
857 (CAV1)	0.62	0.71	0.54	0.66	0.64	0.60	0.68	0.62	0.59	0.57	0.56	0.62	0.57	0.60	0.65	0.60	0.65	1.00	0.67	0.63	0.68	0.71	0.61	0.57	0.62	0.64	0.60	0.55	0.58	0.63	0.57	0.62	1.00	0.61	0.56	0.59	0.67	0.61	0.57	0.52	0.63	0.70	0.55	0.67	1.00	0.50	0.60	0.64	0.54	0.60
7412 (VCAM1)	0.54	0.52	0.38	0.53	0.51	0.46	0.57	0.45	0.45	0.36	0.42	0.50	0.39	0.48	0.55	0.47	0.55	0.66	0.55	0.44	0.56	0.50	0.48	0.46	0.50	0.55	0.43	0.49	0.42	0.45	0.43	0.49	0.82	0.47	0.40	0.40	0.61	0.52	0.43	0.39	0.54	0.56	0.41	0.49	0.50	1.00	0.49	0.51	0.43	0.57
7132 (TNFRSF1A)	0.67	0.63	0.47	0.65	0.66	0.54	0.70	0.55	0.48	0.45	0.48	0.59	0.49	0.59	0.68	0.54	0.68	0.82	0.68	0.54	0.69	0.62	0.88	0.53	0.62	0.67	0.50	0.59	0.55	0.53	0.53	0.57	1.00	0.57	0.48	0.51	0.73	0.61	0.52	0.46	0.67	0.69	0.45	0.61	0.60	0.49	1.00	0.87	0.48	0.55
4055 (LTBR)	0.68	0.71	0.51	0.69	0.74	0.60	0.75	0.57	0.51	0.48	0.58	0.69	0.54	0.61	0.68	0.55	0.68	0.82	0.82	0.56	0.73	0.70	0.97	0.55	0.64	0.68	0.52	0.59	0.57	0.58	0.55	0.61	1.00	0.63	0.51	0.54	0.73	0.73	0.55	0.47	0.68	0.80	0.47	0.63	0.64	0.51	0.87	1.00	0.49	0.57
6347 (CCL2)	0.52	0.54	0.38	0.58	0.50	0.74	0.55	0.69	0.51	0.36	0.41	0.67	0.39	0.70	0.66	0.50	0.66	1.00	0.56	0.65	0.58	0.54	0.47	0.43	0.73	0.61	0.42	0.61	0.42	0.46	0.43	0.50	0.82	0.46	0.63	0.40	0.68	0.54	0.71	0.44	0.56	0.54	0.42	0.48	0.54	0.43	0.48	0.49	1.00	0.53
6868 (ADAM17)	0.58	0.61	0.47	0.60	0.61	0.53	0.63	0.53	0.52	0.45	0.69	0.57	0.48	0.55	0.69	0.55	0.65	0.84	0.62	0.52	0.64	0.59	0.54	0.53	0.57	0.65	0.61	0.62	0.51	0.52	0.52	0.63	1.00	0.57	0.50	0.49	0.66	0.58	0.50	0.47	0.59	0.63	0.48	0.55	0.60	0.57	0.55	0.57	0.53	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
TNF	Human	Vastus Lateralis Biopsy Samples	-	4300 m	1 day	upregulated	-	RT-PCR	Western US	Americans	-	Ameriacans at 50 m, Natick, Massachusetts, USA	30009538
TNF	Human	Blood	-	3250 m	4 day	upregulated	1.78	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776
TNF	Human	Blood	-	3250 m	4 day	upregulated	1.78	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
NFKB1	4790	TNF	7124	proximal_filtered	22955619	TRANSFAC
HDAC3	8841	TNF	7124	Unknown	11259372	TRUSST
HSF1	3297	TNF	7124	Unknown	11118053	TRUSST
NR4A1	3164	TNF	7124	Unknown	20169197	TRUSST
ATF2	1386	TNF	7124	Unknown	17513757	TRUSST
HDAC11	79885	TNF	7124	Unknown	11259372	TRUSST
JUN	3725	TNF	7124	Unknown	10586089	TRUSST
E2F1	1869	TNF	7124	Repression	15228586	TRUSST
ETV4	2118	TNF	7124	Activation	11478739	TRUSST
CEBPB	1051	TNF	7124	Activation	11478739	TRUSST
EGR1	1958	TNF	7124	Unknown	11259372	TRUSST
HMGB2	3148	TNF	7124	Unknown	10760799	TRUSST
NFAT5	10725	TNF	7124	Unknown	10586089	TRUSST
IRF5	3663	TNF	7124	Activation	16604092	TRUSST
LRRFIP1	9208	TNF	7124	Activation	16604092	TRUSST
CEBPD	1052	TNF	7124	Unknown	11259372	TRUSST
SP1	6667	TNF	7124	Unknown	10586089	TRUSST
RELA	5970	TNF	7124	Activation	17541284	TRUSST
SPI1	6688	TNF	7124	Unknown	10049733	TRUSST
SIRT1	23411	TNF	7124	Repression	20169197	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT006787	hsa-miR-19a-3p	Homo sapiens	TNF	7124	Homo sapiens	Luciferase reporter assay	Functional MTI	21271217
MIRT006857	hsa-miR-203a-3p	Homo sapiens	TNF	7124	Homo sapiens	Luciferase reporter assay	Functional MTI	22917968
MIRT006787	hsa-miR-19a-3p	Homo sapiens	TNF	7124	Homo sapiens	Luciferase reporter assay	Functional MTI	26041742
MIRT006787	hsa-miR-19a-3p	Homo sapiens	TNF	7124	Homo sapiens	Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23795660
MIRT053456	hsa-miR-452-5p	Homo sapiens	TNF	7124	Homo sapiens	Microarray	Functional MTI (Weak)	23807165
MIRT054325	hsa-miR-187-3p	Homo sapiens	TNF	7124	Homo sapiens	Immunoblot//Luciferase reporter assay//qRT-PCR	Functional MTI	23071313
MIRT054762	hsa-miR-130a-3p	Homo sapiens	TNF	7124	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blotting	Functional MTI	24885472
MIRT054762	hsa-miR-130a-3p	Homo sapiens	TNF	7124	Homo sapiens	ChIP//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26435691
MIRT054762	hsa-miR-130a-3p	Homo sapiens	TNF	7124	Homo sapiens	qRT-PCR//Western blot	Non-Functional MTI	26045761
MIRT437418	hsa-miR-143-3p	Homo sapiens	TNF	7124	Homo sapiens	Luciferase reporter assay//qRT-PCR	Functional MTI	23804075
MIRT733472	hsa-miR-125b-5p	Homo sapiens	TNF	7124	Homo sapiens	ChIP//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26435691
MIRT733712	hsa-miR-24-3p	Homo sapiens	TNF	7124	Homo sapiens	Microarray//qRT-PCR	Functional MTI (Weak)	28057018
MIRT733989	hsa-miR-34a-5p	Homo sapiens	TNF	7124	Homo sapiens	PCR array	Functional MTI (Weak)	28097098
MIRT734730	hsa-miR-17-5p	Homo sapiens	TNF	7124	Homo sapiens	Luciferase reporter assay	Functional MTI	26041742

Gene Ontology

ID	GO ID	GO Term	GO Type
7124	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
7124	GO:0000185	activation of MAPKKK activity	GOTERM_BP_DIRECT
7124	GO:0002740	negative regulation of cytokine secretion involved in immune response	GOTERM_BP_DIRECT
7124	GO:0010693	negative regulation of alkaline phosphatase activity	GOTERM_BP_DIRECT
7124	GO:0030316	osteoclast differentiation	GOTERM_BP_DIRECT
7124	GO:0045080	positive regulation of chemokine biosynthetic process	GOTERM_BP_DIRECT
7124	GO:0045123	cellular extravasation	GOTERM_BP_DIRECT
7124	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	GOTERM_BP_DIRECT
7124	GO:0000187	activation of MAPK activity	GOTERM_BP_DIRECT
7124	GO:0006955	immune response	GOTERM_BP_DIRECT
7124	GO:0007249	I-kappaB kinase/NF-kappaB signaling	GOTERM_BP_DIRECT
7124	GO:0030730	sequestering of triglyceride	GOTERM_BP_DIRECT
7124	GO:0043406	positive regulation of MAP kinase activity	GOTERM_BP_DIRECT
7124	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	GOTERM_BP_DIRECT
7124	GO:0006954	inflammatory response	GOTERM_BP_DIRECT
7124	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	GOTERM_BP_DIRECT
7124	GO:0032800	receptor biosynthetic process	GOTERM_BP_DIRECT
7124	GO:0034116	positive regulation of heterotypic cell-cell adhesion	GOTERM_BP_DIRECT
7124	GO:0045670	regulation of osteoclast differentiation	GOTERM_BP_DIRECT
7124	GO:0050715	positive regulation of cytokine secretion	GOTERM_BP_DIRECT
7124	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	GOTERM_BP_DIRECT
7124	GO:0097191	extrinsic apoptotic signaling pathway	GOTERM_BP_DIRECT
7124	GO:1903140	regulation of establishment of endothelial barrier	GOTERM_BP_DIRECT
7124	GO:2000343	positive regulation of chemokine	GOTERM_BP_DIRECT
7124	GO:0005887	integral component of plasma membrane	GOTERM_CC_DIRECT
7124	GO:0001819	positive regulation of cytokine production	GOTERM_BP_DIRECT
7124	GO:0006006	glucose metabolic process	GOTERM_BP_DIRECT
7124	GO:0043491	protein kinase B signaling	GOTERM_BP_DIRECT
7124	GO:0045071	negative regulation of viral genome replication	GOTERM_BP_DIRECT
7124	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GOTERM_BP_DIRECT
7124	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GOTERM_BP_DIRECT
7124	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GOTERM_BP_DIRECT
7124	GO:0010628	positive regulation of gene expression	GOTERM_BP_DIRECT
7124	GO:0030198	extracellular matrix organization	GOTERM_BP_DIRECT
7124	GO:0010629	negative regulation of gene expression	GOTERM_BP_DIRECT
7124	GO:0045662	negative regulation of myoblast differentiation	GOTERM_BP_DIRECT
7124	GO:0045668	negative regulation of osteoblast differentiation	GOTERM_BP_DIRECT
7124	GO:0045860	positive regulation of protein kinase activity	GOTERM_BP_DIRECT
7124	GO:1903347	negative regulation of bicellular tight junction assembly	GOTERM_BP_DIRECT
7124	GO:1904999	positive regulation of leukocyte adhesion to arterial endothelial cell	GOTERM_BP_DIRECT
7124	GO:2000010	positive regulation of protein localization to cell surface	GOTERM_BP_DIRECT
7124	GO:0005164	platelet-derived growth factor receptor binding	GOTERM_MF_DIRECT
7124	GO:0046325	negative regulation of glucose import	GOTERM_BP_DIRECT
7124	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	GOTERM_BP_DIRECT
7124	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GOTERM_BP_DIRECT
7124	GO:0009897	external side of plasma membrane	GOTERM_CC_DIRECT
7124	GO:0016020	membrane	GOTERM_CC_DIRECT
7124	GO:0002439	chronic inflammatory response to antigenic stimulus	GOTERM_BP_DIRECT
7124	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GOTERM_BP_DIRECT
7124	GO:0000060	protein import into nucleus	GOTERM_BP_DIRECT
7124	GO:0001934	positive regulation of protein phosphorylation	GOTERM_BP_DIRECT
7124	GO:0009651	response to salt stress	GOTERM_BP_DIRECT
7124	GO:0042127	regulation of cell proliferation	GOTERM_BP_DIRECT
7124	GO:0032755	positive regulation of interleukin-6 production	GOTERM_BP_DIRECT
7124	GO:0033209	tumor necrosis factor-mediated signaling pathway	GOTERM_BP_DIRECT
7124	GO:0043243	positive regulation of protein complex disassembly	GOTERM_BP_DIRECT
7124	GO:0045416	positive regulation of interleukin-8 biosynthetic process	GOTERM_BP_DIRECT
7124	GO:0031663	lipopolysaccharide-mediated signaling pathway	GOTERM_BP_DIRECT
7124	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GOTERM_BP_DIRECT
7124	GO:0043242	negative regulation of protein complex disassembly	GOTERM_BP_DIRECT
7124	GO:0044130	negative regulation of growth of symbiont in host	GOTERM_BP_DIRECT
7124	GO:0051533	positive regulation of NFAT protein import into nucleus	GOTERM_BP_DIRECT
7124	GO:0042802	identical protein binding	GOTERM_MF_DIRECT
7124	GO:0009986	cell surface	GOTERM_CC_DIRECT
7124	GO:0016021	integral component of membrane	GOTERM_CC_DIRECT
7124	GO:0045672	positive regulation of osteoclast differentiation	GOTERM_BP_DIRECT
7124	GO:0071677	positive regulation of mononuclear cell migration	GOTERM_BP_DIRECT
7124	GO:0097527	necroptotic signaling pathway	GOTERM_BP_DIRECT
7124	GO:0001891	phagocytic cup	GOTERM_CC_DIRECT
7124	GO:0045121	membrane raft	GOTERM_CC_DIRECT
7124	GO:0000165	MAPK cascade	GOTERM_BP_DIRECT
7124	GO:0030866	cortical actin cytoskeleton organization	GOTERM_BP_DIRECT
7124	GO:0032722	positive regulation of chemokine production	GOTERM_BP_DIRECT
7124	GO:0032729	positive regulation of interferon-gamma production	GOTERM_BP_DIRECT
7124	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	GOTERM_BP_DIRECT
7124	GO:0042346	positive regulation of NF-kappaB import into nucleus	GOTERM_BP_DIRECT
7124	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GOTERM_BP_DIRECT
7124	GO:0007254	JNK cascade	GOTERM_BP_DIRECT
7124	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GOTERM_BP_DIRECT
7124	GO:0031622	positive regulation of fever generation	GOTERM_BP_DIRECT
7124	GO:0032757	positive regulation of interleukin-8 production	GOTERM_BP_DIRECT
7124	GO:0006959	humoral immune response	GOTERM_BP_DIRECT
7124	GO:0010888	negative regulation of lipid storage	GOTERM_BP_DIRECT
7124	GO:0031334	positive regulation of protein complex assembly	GOTERM_BP_DIRECT
7124	GO:0043065	positive regulation of apoptotic process	GOTERM_BP_DIRECT
7124	GO:0043068	positive regulation of programmed cell death	GOTERM_BP_DIRECT
7124	GO:0043507	positive regulation of JUN kinase activity	GOTERM_BP_DIRECT
7124	GO:0009615	response to virus	GOTERM_BP_DIRECT
7124	GO:0032715	negative regulation of interleukin-6 production	GOTERM_BP_DIRECT
7124	GO:0045892	negative regulation of transcription	GOTERM_BP_DIRECT
7124	GO:0061048	negative regulation of branching involved in lung morphogenesis	GOTERM_BP_DIRECT
7124	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GOTERM_BP_DIRECT
7124	GO:0071550	death-inducing signaling complex assembly	GOTERM_BP_DIRECT
7124	GO:0005576	extracellular region	GOTERM_CC_DIRECT
7124	GO:0045785	positive regulation of cell adhesion	GOTERM_BP_DIRECT
7124	GO:0051222	positive regulation of protein transport	GOTERM_BP_DIRECT
7124	GO:0051897	positive regulation of protein kinase B signaling	GOTERM_BP_DIRECT
7124	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	GOTERM_BP_DIRECT
7124	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GOTERM_BP_DIRECT
7124	GO:0044212	transcription regulatory region DNA binding	GOTERM_MF_DIRECT
7124	GO:0048661	positive regulation of smooth muscle cell proliferation	GOTERM_BP_DIRECT
7124	GO:0071222	cellular response to lipopolysaccharide	GOTERM_BP_DIRECT
7124	GO:0071407	cellular response to organic cyclic compound	GOTERM_BP_DIRECT
7124	GO:1901671	positive regulation of superoxide dismutase activity	GOTERM_BP_DIRECT
7124	GO:0002020	protease binding	GOTERM_MF_DIRECT
7124	GO:0045429	positive regulation of nitric oxide biosynthetic process	GOTERM_BP_DIRECT
7124	GO:0045599	negative regulation of fat cell differentiation	GOTERM_BP_DIRECT
7124	GO:0045893	positive regulation of transcription	GOTERM_BP_DIRECT
7124	GO:0050830	defense response to Gram-positive bacterium	GOTERM_BP_DIRECT
7124	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GOTERM_BP_DIRECT
7124	GO:0060557	positive regulation of vitamin D biosynthetic process	GOTERM_BP_DIRECT
7124	GO:0072659	protein localization to plasma membrane	GOTERM_BP_DIRECT
7124	GO:0005515	protein binding	GOTERM_MF_DIRECT
7124	GO:0050766	positive regulation of phagocytosis	GOTERM_BP_DIRECT
7124	GO:0071803	positive regulation of podosome assembly	GOTERM_BP_DIRECT
7124	GO:0050796	regulation of insulin secretion	GOTERM_BP_DIRECT
7124	GO:0090002	establishment of protein localization to plasma membrane	GOTERM_BP_DIRECT
7124	GO:0005125	cytokine activity	GOTERM_MF_DIRECT
7124	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
7124	GO:0045994	positive regulation of translational initiation by iron	GOTERM_BP_DIRECT
7124	GO:0046330	positive regulation of JNK cascade	GOTERM_BP_DIRECT
7124	GO:0051023	regulation of immunoglobulin secretion	GOTERM_BP_DIRECT
7124	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
7124	GO:0048566	embryonic digestive tract development	GOTERM_BP_DIRECT
7124	GO:0050901	leukocyte tethering or rolling	GOTERM_BP_DIRECT
7124	GO:0050995	negative regulation of lipid catabolic process	GOTERM_BP_DIRECT
7124	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	GOTERM_BP_DIRECT
7124	GO:2000304	positive regulation of ceramide biosynthetic process	GOTERM_BP_DIRECT
7124	GO:0051384	response to glucocorticoid	GOTERM_BP_DIRECT
7124	GO:0051798	positive regulation of hair follicle development	GOTERM_BP_DIRECT
7124	GO:0005615	extracellular space	GOTERM_CC_DIRECT
7124	GO:0055037	recycling endosome	GOTERM_CC_DIRECT
7124	GO:0060693	regulation of branching involved in salivary gland morphogenesis	GOTERM_BP_DIRECT
7124	GO:0071230	cellular response to amino acid stimulus	GOTERM_BP_DIRECT
7124	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GOTERM_BP_DIRECT
7124	GO:2000377	regulation of reactive oxygen species metabolic process	GOTERM_BP_DIRECT
7124	GO:0071316	cellular response to nicotine	GOTERM_BP_DIRECT
7124	GO:2000334	positive regulation of blood microparticle formation	GOTERM_BP_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
7124	hsa04010	MAPK signaling pathway
7124	hsa04060	Cytokine-cytokine receptor interaction
7124	hsa04064	NF-kappa B signaling pathway
7124	hsa04071	Sphingolipid signaling pathway
7124	hsa04150	mTOR signaling pathway
7124	hsa04210	Apoptosis
7124	hsa04380	Osteoclast differentiation
7124	hsa04621	NOD-like receptor signaling pathway
7124	hsa04660	T cell receptor signaling pathway
7124	hsa04650	Natural killer cell mediated cytotoxicity
7124	hsa04350	TGF-beta signaling pathway
7124	hsa04612	Antigen processing and presentation
7124	hsa04640	Hematopoietic cell lineage
7124	hsa04620	Toll-like receptor signaling pathway
7124	hsa04622	RIG-I-like receptor signaling pathway
7124	hsa04664	Fc epsilon RI signaling pathway
7124	hsa04668	TNF signaling pathway
7124	hsa04940	Type I diabetes mellitus
7124	hsa04920	Adipocytokine signaling pathway
7124	hsa04930	Type II diabetes mellitus
7124	hsa05014	Amyotrophic lateral sclerosis
7124	hsa04932	Non-alcoholic fatty liver disease
7124	hsa04931	Insulin resistance
7124	hsa05010	Alzheimer's disease
7124	hsa05133	Pertussis
7124	hsa05134	Legionellosis
7124	hsa05164	Influenza A
7124	hsa05146	Amoebiasis
7124	hsa05168	Herpes simplex infection
7124	hsa05140	Leishmaniasis
7124	hsa05143	African trypanosomiasis
7124	hsa05142	Chagas disease
7124	hsa05160	Hepatitis C
7124	hsa05145	Toxoplasmosis
7124	hsa05152	Tuberculosis
7124	hsa05161	Hepatitis B
7124	hsa05166	HTLV-I infection
7124	hsa05144	Malaria
7124	hsa05205	Proteoglycans in cancer
7124	hsa05321	Inflammatory bowel disease
7124	hsa05310	Asthma
7124	hsa05332	Graft-versus-host disease
7124	hsa05322	Systemic lupus erythematosus
7124	hsa05330	Allograft rejection
7124	hsa05323	Rheumatoid arthritis
7124	hsa05410	Hypertrophic cardiomyopathy
7124	hsa05414	Dilated cardiomyopathy

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
TNF	7124	Rheumatoid Arthritis	C0003873	Disease or Syndrome	0.7	0.263	0.966	disease
TNF	7124	Bladder Neoplasm	C0005695	Neoplastic Process	0.4	0.263	0.966	group
TNF	7124	Atherosclerosis	C0004153	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Malignant neoplasm of urinary bladder	C0005684	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Anemia	C0002871	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Refractory anemias	C0002893	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Anthracosis	C0003165	Disease or Syndrome	0.37	0.263	0.966	disease
TNF	7124	Carcinoma, Transitional Cell	C0007138	Neoplastic Process	0.32	0.263	0.966	disease
TNF	7124	Fatty Liver	C0015695	Disease or Syndrome	0.39	0.263	0.966	disease
TNF	7124	Fever	C0015967	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Hepatolenticular Degeneration	C0019202	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Diaphragmatic Hernia	C0019284	Anatomical Abnormality	0.3	0.263	0.966	phenotype
TNF	7124	Coxsackievirus Infections	C0010246	Disease or Syndrome	0.3	0.263	0.966	group
TNF	7124	Diabetes Mellitus, Insulin-Dependent	C0011854	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Fanconi Anemia	C0015625	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Hypotension	C0020649	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Leishmaniasis, Cutaneous	C0023283	Disease or Syndrome	0.38	0.263	0.966	disease
TNF	7124	Glioma	C0017638	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Pulmonary Hypertension	C0020542	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Kidney Failure, Chronic	C0022661	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Liver diseases	C0023895	Disease or Syndrome	0.4	0.263	0.966	group
TNF	7124	Arthritis, Psoriatic	C0003872	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Alloxan Diabetes	C0002152	Experimental Model of Disease	0.3	0.263	0.966	disease
TNF	7124	Cachexia	C0006625	Sign or Symptom	0.4	0.263	0.966	phenotype
TNF	7124	Adenocarcinoma	C0001418	Neoplastic Process	0.4	0.263	0.966	group
TNF	7124	Anemia, Sickle Cell	C0002895	Disease or Syndrome	0.34	0.263	0.966	disease
TNF	7124	Malignant neoplasm of breast	C0006142	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Dermatomyositis	C0011633	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Diabetes Mellitus, Non-Insulin-Dependent	C0011860	Disease or Syndrome	0.6	0.263	0.966	disease
TNF	7124	Cardiac Arrest	C0018790	Disease or Syndrome	0.56	0.263	0.966	disease
TNF	7124	Hepatitis, Toxic	C0019193	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Leishmaniasis	C0023281	Disease or Syndrome	0.35	0.263	0.966	disease
TNF	7124	Malaria	C0024530	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Listeriosis	C0023860	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Chronic Obstructive Airway Disease	C0024117	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Diabetes Mellitus, Experimental	C0011853	Experimental Model of Disease	0.3	0.263	0.966	disease
TNF	7124	Hepatoma, Novikoff	C0019208	Experimental Model of Disease; Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Hypersensitivity	C0020517	Pathologic Function	0.3	0.263	0.966	group
TNF	7124	Congestive heart failure	C0018802	Disease or Syndrome	0.6	0.263	0.966	disease
TNF	7124	Hemochromatosis	C0018995	Disease or Syndrome	0.34	0.263	0.966	disease
TNF	7124	Lung diseases	C0024115	Disease or Syndrome	0.57	0.263	0.966	group
TNF	7124	Anxiety Disorders	C0003469	Mental or Behavioral Dysfunction	0.31	0.263	0.966	group
TNF	7124	Arthritis, Adjuvant-Induced	C0003865	Experimental Model of Disease	0.3	0.263	0.966	disease
TNF	7124	Malignant tumor of colon	C0007102	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Albuminuria	C0001925	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Anorexia	C0003123	Disease or Syndrome	0.37	0.263	0.966	disease
TNF	7124	Arthritis, Infectious	C0003869	Disease or Syndrome	0.31	0.263	0.966	group
TNF	7124	Brain Ischemia	C0007786	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Crohn Disease	C0010346	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Scleroderma	C0011644	Disease or Syndrome	0.35	0.263	0.966	disease
TNF	7124	Drug Allergy	C0013182	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Edema	C0013604	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Glomerulonephritis	C0017658	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Hepatic Encephalopathy	C0019151	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Hepatitis, Alcoholic	C0019187	Disease or Syndrome	0.39	0.263	0.966	disease
TNF	7124	Left-Sided Heart Failure	C0023212	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Heart failure	C0018801	Disease or Syndrome	0.6	0.263	0.966	disease
TNF	7124	Hepatoma, Morris	C0019207	Experimental Model of Disease; Neoplastic Process	0.31	0.263	0.966	disease
TNF	7124	Inflammation	C0021368	Pathologic Function	0.4	0.263	0.966	phenotype
TNF	7124	Fibrosis	C0016059	Pathologic Function	0.34	0.263	0.966	phenotype
TNF	7124	Colitis	C0009319	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Colorectal Carcinoma	C0009402	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Cardiomegaly	C0018800	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Hypertensive disease	C0020538	Disease or Syndrome	0.6	0.263	0.966	group
TNF	7124	Hypoglycemia	C0020615	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Leishmaniasis, Visceral	C0023290	Disease or Syndrome	0.35	0.263	0.966	disease
TNF	7124	Liver neoplasms	C0023903	Neoplastic Process	0.4	0.263	0.966	group
TNF	7124	Liver Neoplasms, Experimental	C0023904	Experimental Model of Disease; Neoplastic Process	0.3	0.263	0.966	group
TNF	7124	Alzheimer's Disease	C0002395	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Asbestosis	C0003949	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Berylliosis	C0005138	Injury or Poisoning	0.31	0.263	0.966	disease
TNF	7124	Arthritis, Viral	C0003875	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Asthma	C0004096	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Burn injury	C0006434	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Cholestasis	C0008370	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Bronchiectasis	C0006267	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Chlamydia Infections	C0008149	Disease or Syndrome	0.33	0.263	0.966	group
TNF	7124	Cholestasis, Extrahepatic	C0005398	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Cerebral Edema	C0006114	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Ulcerative Colitis	C0009324	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Heat Stroke	C0018843	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Hyperbilirubinemia	C0020433	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Hypercalcemia	C0020437	Disease or Syndrome	0.33	0.263	0.966	disease
TNF	7124	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.263	0.966	disease
TNF	7124	Lung Neoplasms	C0024121	Neoplastic Process	0.37	0.263	0.966	group
TNF	7124	Colonic Neoplasms	C0009375	Neoplastic Process	0.33	0.263	0.966	group
TNF	7124	Hepatic Coma	C0019147	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Hypothermia, natural	C0020672	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Inflammatory Bowel Diseases	C0021390	Disease or Syndrome	0.6	0.263	0.966	group
TNF	7124	Insulin Resistance	C0021655	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Hemolytic-Uremic Syndrome	C0019061	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Liver Cirrhosis, Alcoholic	C0023891	Disease or Syndrome	0.35	0.263	0.966	disease
TNF	7124	Colorectal Neoplasms	C0009404	Neoplastic Process	0.38	0.263	0.966	group
TNF	7124	Presenile dementia	C0011265	Mental or Behavioral Dysfunction	0.39	0.263	0.966	disease
TNF	7124	Hyperalgesia	C0020429	Sign or Symptom	0.32	0.263	0.966	phenotype
TNF	7124	Kidney Failure, Acute	C0022660	Disease or Syndrome	0.33	0.263	0.966	disease
TNF	7124	Neoplasms, Experimental	C0027659	Experimental Model of Disease; Neoplastic Process	0.3	0.263	0.966	group
TNF	7124	Oral Submucous Fibrosis	C0029172	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Pain	C0030193	Sign or Symptom	0.4	0.263	0.966	phenotype
TNF	7124	Premature Birth	C0151526	Pathologic Function	0.33	0.263	0.966	phenotype
TNF	7124	Liver Failure, Acute	C0162557	Disease or Syndrome	0.39	0.263	0.966	disease
TNF	7124	Myocardial Infarction	C0027051	Disease or Syndrome	0.6	0.263	0.966	disease
TNF	7124	Osteoporosis, Postmenopausal	C0029458	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Parkinson Disease	C0030567	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Pulmonary Emphysema	C0034067	Disease or Syndrome	0.37	0.263	0.966	disease
TNF	7124	Hamman-Rich syndrome	C0085786	Disease or Syndrome	0.35	0.263	0.966	disease
TNF	7124	Thrombus	C0087086	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Dermatitis, Allergic Contact	C0162820	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Pain, Burning	C0234230	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Multiple Organ Failure	C0026766	Pathologic Function	0.31	0.263	0.966	phenotype
TNF	7124	Necrosis	C0027540	Organ or Tissue Function	0.3	0.263	0.966	phenotype
TNF	7124	Neoplasm Invasiveness	C0027626	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Pancreatic Neoplasm	C0030297	Neoplastic Process	0.34	0.263	0.966	disease
TNF	7124	Psoriasis	C0033860	Disease or Syndrome	0.5	0.263	0.966	disease
TNF	7124	Reperfusion Injury	C0035126	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Septic Shock	C0036983	Pathologic Function	0.31	0.263	0.966	phenotype
TNF	7124	Injuries, Acute Brain	C0085742	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Carcinoma, Granular Cell	C0205644	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Neurogenic Muscular Atrophy	C0270948	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Pleurisy	C0032231	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Endotoxic shock	C0036981	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	mixed gliomas	C0259783	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Linear Scleroderma	C0263409	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Panacinar Emphysema	C0264393	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Brain Injuries	C0270611	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Arsenic Poisoning, Inorganic	C0274861	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Septicemia	C0036690	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Soft Tissue Neoplasms	C0037579	Neoplastic Process	0.3	0.263	0.966	group
TNF	7124	Leishmaniasis, New World	C0086540	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Pleoconial Myopathies	C0162669	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Adenocarcinoma, Oxyphilic	C0205642	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Nerve Degeneration	C0027746	Cell or Molecular Dysfunction	0.3	0.263	0.966	phenotype
TNF	7124	Neuralgia	C0027796	Sign or Symptom	0.35	0.263	0.966	phenotype
TNF	7124	Respiratory Hypersensitivity	C0035228	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Dermatologic disorders	C0037274	Disease or Syndrome	0.36	0.263	0.966	group
TNF	7124	Thrombosis	C0040053	Pathologic Function	0.31	0.263	0.966	phenotype
TNF	7124	Adenocarcinoma, Basal Cell	C0205641	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Cholestasis of pregnancy	C0268318	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Myocarditis	C0027059	Disease or Syndrome	0.35	0.263	0.966	disease
TNF	7124	Nausea	C0027497	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Neoplasm Metastasis	C0027627	Neoplastic Process	0.4	0.263	0.966	phenotype
TNF	7124	Trigeminal Neuralgia	C0040997	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Neuralgia, Vidian	C0042656	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Tachyarrhythmia	C0080203	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Migraine Disorders	C0149931	Disease or Syndrome	0.4	0.263	0.966	group
TNF	7124	Mitochondrial Myopathies	C0162670	Disease or Syndrome	0.3	0.263	0.966	group
TNF	7124	Cardiovirus Infections	C0206617	Disease or Syndrome	0.3	0.263	0.966	group
TNF	7124	Muscular Atrophy	C0026846	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	nervous system disorder	C0027765	Disease or Syndrome	0.38	0.263	0.966	group
TNF	7124	Obesity	C0028754	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Pustulosis of Palms and Soles	C0030246	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Experimental Hepatoma	C0086404	Experimental Model of Disease; Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Stunned Myocardium	C0206145	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Adult type dermatomyositis	C0221056	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Lytic lesion	C0221204	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Placenta Disorders	C0032045	Pathologic Function	0.3	0.263	0.966	group
TNF	7124	Pleural effusion disorder	C0032227	Disease or Syndrome	0.31	0.263	0.966	group
TNF	7124	Vascular Diseases	C0042373	Disease or Syndrome	0.33	0.263	0.966	group
TNF	7124	Urban cutaneous leishmaniasis	C0086541	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Liver Dysfunction	C0086565	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Vascular System Injuries	C0178324	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Diabetes, Autoimmune	C0205734	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Neuralgia, Stump	C0234249	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Radiating pain	C0234254	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Crohn's disease of the ileum	C0267380	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Pneumonia	C0032285	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Shock, Hemorrhagic	C0036982	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Centriacinar Emphysema	C0221227	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Status Epilepticus	C0038220	Disease or Syndrome	0.51	0.263	0.966	disease
TNF	7124	Myocardial Ischemia	C0151744	Disease or Syndrome	0.35	0.263	0.966	disease
TNF	7124	Crohn's disease of large bowel	C0156147	Disease or Syndrome	0.5	0.263	0.966	disease
TNF	7124	Ache	C0234238	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Ventricular Dysfunction	C0242973	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Petit mal status	C0270823	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Brain Lacerations	C0272945	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Lung Injury	C0273115	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	melanoma	C0025202	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Retinal Diseases	C0035309	Disease or Syndrome	0.37	0.263	0.966	group
TNF	7124	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.4	0.263	0.966	disease
TNF	7124	Cerebrovascular accident	C0038454	Disease or Syndrome	0.4	0.263	0.966	group
TNF	7124	Neuralgia, Supraorbital	C0038870	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Wounds and Injuries	C0043251	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Adenocarcinoma, Tubular	C0205645	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Sarcoma, Spindle Cell	C0205945	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Heart Failure, Right-Sided	C0235527	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Malignant neoplasm of lung	C0242379	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Polymyositis Ossificans	C0263984	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Lobar Pneumonia	C0032300	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Fasting Hypoglycemia	C0271708	Disease or Syndrome	0.3	0.263	0.966	phenotype
TNF	7124	Pulmonary Edema	C0034063	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Stomach Neoplasms	C0038356	Neoplastic Process	0.37	0.263	0.966	group
TNF	7124	Nervous System, Organic Arsenic Poisoning	C0274862	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Gastric ulcer	C0038358	Disease or Syndrome	0.35	0.263	0.966	disease
TNF	7124	Weight Gain	C0043094	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Myocardial Stunning	C0206146	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Dermatomyositis, Childhood Type	C0263666	Disease or Syndrome	0.38	0.263	0.966	disease
TNF	7124	Reactive hypoglycemia	C0271710	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Cardiomyopathies, Primary	C0033141	Disease or Syndrome	0.51	0.263	0.966	group
TNF	7124	Radiation Injuries, Experimental	C0034531	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Myocardial Diseases, Secondary	C0036529	Disease or Syndrome	0.5	0.263	0.966	group
TNF	7124	Compression of spinal cord	C0037926	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Megaconial Myopathies	C0162668	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Carcinoma, Cribriform	C0205643	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Sepsis	C0243026	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Asthma, Occupational	C0264423	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Hypothermia, Accidental	C0274285	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Milk-Alkali Syndrome	C0026141	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Pregnancy Complications, Cardiovascular	C0032963	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Pyemia	C0034189	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Localized scleroderma	C0036420	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Streptozotocin Diabetes	C0038433	Experimental Model of Disease	0.3	0.263	0.966	disease
TNF	7124	Fibromatosis, Aggressive	C0079218	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Polymyositis	C0085655	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Thyroid Gland Follicular Adenoma	C0151468	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Pulmonary Fibrosis	C0034069	Disease or Syndrome	0.37	0.263	0.966	disease
TNF	7124	Respiratory Tract Diseases	C0035242	Disease or Syndrome	0.32	0.263	0.966	group
TNF	7124	Tachycardia	C0039231	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Thyroid Neoplasm	C0040136	Neoplastic Process	0.31	0.263	0.966	disease
TNF	7124	Urticaria	C0042109	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Injury wounds	C0043250	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Anasarca	C0151603	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Sarcoma, Epithelioid	C0205944	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Neuralgia, Atypical	C0234247	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Vasogenic Brain Edema	C0750969	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Malignant neoplasm of liver	C0345904	Neoplastic Process	0.36	0.263	0.966	disease
TNF	7124	Malignant neoplasm of pancreas	C0346647	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Simple Partial Status Epilepticus	C0751524	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Arsenic Poisoning	C0311375	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Stable angina	C0340288	Disease or Syndrome	0.33	0.263	0.966	disease
TNF	7124	Hibernation, Myocardial	C0376416	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Pain, Crushing	C0458259	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Vasogenic Cerebral Edema	C0472387	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Acute Confusional Senile Dementia	C0546126	Mental or Behavioral Dysfunction	0.3	0.263	0.966	disease
TNF	7124	Status Epilepticus, Subclinical	C0751522	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Diabetic Cardiomyopathies	C0853897	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Complex Partial Status Epilepticus	C0393734	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Hyperhomocysteinemia	C0598608	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Toxic Shock Syndrome	C0600327	Disease or Syndrome	0.54	0.263	0.966	disease
TNF	7124	Pain, Migratory	C0751407	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Acute Cerebrovascular Accidents	C0751956	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Experimental Lung Inflammation	C0887898	Experimental Model of Disease	0.3	0.263	0.966	disease
TNF	7124	Allodynia	C0458247	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Fulminant Hepatic Failure with Cerebral Edema	C0751197	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Paroxysmal Nerve Pain	C0751373	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Drug-Induced Liver Disease	C0860207	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Familial Alzheimer Disease (FAD)	C0276496	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Neuralgia, Perineal	C0423711	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Cardiopulmonary Arrest	C0600228	Pathologic Function	0.5	0.263	0.966	phenotype
TNF	7124	Hyperalgesia, Secondary	C0751212	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Non-Convulsive Status Epilepticus	C0751523	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Cardiomyopathies	C0878544	Disease or Syndrome	0.59	0.263	0.966	group
TNF	7124	Anxiety States, Neurotic	C0376280	Mental or Behavioral Dysfunction	0.3	0.263	0.966	disease
TNF	7124	Neuralgia, Iliohypogastric Nerve	C0423712	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Pain, Splitting	C0458257	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Suffering, Physical	C0751408	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Trigeminal Neuralgia, Idiopathic	C0393786	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Neurogenic Inflammation	C0600467	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Alzheimer Disease, Early Onset	C0750901	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Hepatic Stupor	C0751198	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Hyperalgesia, Primary	C0751211	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Cytotoxic Brain Edema	C0750970	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Hyperalgesia, Thermal	C0751214	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Insulin Sensitivity	C0920563	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Grand Mal Status Epilepticus	C0311335	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Brain Injuries, Focal	C0452047	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Breast Carcinoma	C0678222	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Carditis	C0869523	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Secondary Trigeminal Neuralgia	C0393787	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Chronic Alcoholic Hepatitis	C0524610	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Neuralgia, Ilioinguinal	C0751371	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Manganese Poisoning	C0677050	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Regional enteritis	C0678202	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Alzheimer's Disease, Focal Onset	C0750900	Mental or Behavioral Dysfunction	0.3	0.263	0.966	disease
TNF	7124	Tactile Allodynia	C0751213	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Nerve Pain	C0751372	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Arsenic Encephalopathy	C0751851	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Hereditary hemochromatosis	C0392514	Disease or Syndrome	0.33	0.263	0.966	disease
TNF	7124	Alzheimer Disease, Late Onset	C0494463	Mental or Behavioral Dysfunction	0.33	0.263	0.966	disease
TNF	7124	Thyroid carcinoma	C0549473	Neoplastic Process	0.39	0.263	0.966	disease
TNF	7124	Polymyositis, Idiopathic	C0554591	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Brittle diabetes	C0342302	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	HIV Wasting Syndrome	C0343755	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Conus Medullaris Syndrome	C0742803	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Arsenic Induced Polyneuropathy	C0751852	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Cerebral Ischemia	C0917798	Disease or Syndrome	0.32	0.263	0.966	disease
TNF	7124	Cytotoxic Cerebral Edema	C0472388	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Malignant Glioma	C0555198	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Venous Thromboembolism	C1861172	Disease or Syndrome	0.3	0.263	0.966	phenotype
TNF	7124	Sarcoma	C1261473	Neoplastic Process	0.4	0.263	0.966	group
TNF	7124	Hepatitis, Drug-Induced	C1262760	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Atherogenesis	C1563937	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.263	0.966	disease
TNF	7124	Morphea	C1527383	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Liver carcinoma	C2239176	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Acute Coronary Syndrome	C0948089	Disease or Syndrome	0.38	0.263	0.966	disease
TNF	7124	Familial intrahepatic cholestasis of pregnancy	C3489728	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Arthritis, Bacterial	C1692886	Disease or Syndrome	0.3	0.263	0.966	group
TNF	7124	Myocardial Failure	C1959583	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Drug-Induced Acute Liver Injury	C3658290	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1	C3887485	Finding	0.3	0.263	0.966	phenotype
TNF	7124	Amyotrophic Lateral Sclerosis, Sporadic	C1862941	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Mechanical Allodynia	C2936719	Sign or Symptom	0.3	0.263	0.966	phenotype
TNF	7124	Arthritis, Collagen-Induced	C0971858	Experimental Model of Disease	0.3	0.263	0.966	disease
TNF	7124	Beryllium Disease	C2350873	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Mammary Neoplasms, Human	C1257931	Neoplastic Process	0.3	0.263	0.966	group
TNF	7124	Cirrhosis	C1623038	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Coronary Restenosis	C0948480	Disease or Syndrome	0.31	0.263	0.966	disease
TNF	7124	Mammary Neoplasms	C1458155	Neoplastic Process	0.4	0.263	0.966	group
TNF	7124	Brain Edema	C1527311	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Severe Sepsis	C1719672	Disease or Syndrome	0.36	0.263	0.966	disease
TNF	7124	Chronic Lung Injury	C2350344	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Arthritis, Suppurative	C3891815	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Acute kidney injury	C2609414	Injury or Poisoning	0.3	0.263	0.966	disease
TNF	7124	Cardiac Hypertrophy	C1383860	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Steatohepatitis	C2711227	Disease or Syndrome	0.4	0.263	0.966	disease
TNF	7124	Colorectal Cancer	C1527249	Neoplastic Process	0.4	0.263	0.966	disease
TNF	7124	Hepatic Form of Wilson Disease	C1527352	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	AMYOTROPHIC LATERAL SCLEROSIS 1	C1862939	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Infection	C3714514	Pathologic Function	0.4	0.263	0.966	group
TNF	7124	Diabetes Mellitus, Ketosis-Prone	C3837958	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Allergic Reaction	C1527304	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Pulmonary Fibrosis - from Asbestos Exposure	C2930617	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Pneumonitis	C3714636	Disease or Syndrome	0.37	0.263	0.966	disease
TNF	7124	Chemical and Drug Induced Liver Injury	C4277682	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Arthritis, Experimental	C0993582	Experimental Model of Disease	0.3	0.263	0.966	disease
TNF	7124	Anxiety neurosis (finding)	C1279420	Mental or Behavioral Dysfunction	0.31	0.263	0.966	disease
TNF	7124	Acute Kidney Insufficiency	C1565662	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Bright Disease	C1704377	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Traumatic injury	C3263723	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Research-Related Injuries	C4046002	Injury or Poisoning	0.3	0.263	0.966	group
TNF	7124	Chemically-Induced Liver Toxicity	C4279912	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Focal Emphysema	C2350878	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	IIeocolitis	C0949272	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Luft Disease	C0949496	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Chronic Airflow Obstruction	C1527303	Disease or Syndrome	0.3	0.263	0.966	disease
TNF	7124	Heart Decompensation	C1961112	Pathologic Function	0.3	0.263	0.966	phenotype
TNF	7124	Major Depressive Disorder	C1269683	Mental or Behavioral Dysfunction	0.38	0.263	0.966	disease
TNF	7124	Depressive disorder	C0011581	Mental or Behavioral Dysfunction	0.4	0.263	0.966	disease
TNF	7124	Mental Depression	C0011570	Mental or Behavioral Dysfunction	0.4	0.263	0.966	disease
TNF	7124	Mood Disorders	C0525045	Mental or Behavioral Dysfunction	0.34	0.263	0.966	group
TNF	7124	Unipolar Depression	C0041696	Mental or Behavioral Dysfunction	0.35	0.263	0.966	disease
TNF	7124	Bipolar Disorder	C0005586	Mental or Behavioral Dysfunction	0.36	0.263	0.966	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
TNF	7124	ABX-0401	None	None	None
TNF	7124	ADALIMUMAB	ADALIMUMAB	CHEMBL1201580	None
TNF	7124	ADALIMUMAB	ADALIMUMAB	CHEMBL1201580	None
TNF	7124	AFELIMOMAB	AFELIMOMAB	CHEMBL2108887	inhibitor
TNF	7124	ADALIMUMAB	ADALIMUMAB	CHEMBL1201580	inhibitor
TNF	7124	ADALIMUMAB	ADALIMUMAB	CHEMBL1201580	antibody
TNF	7124	AME-527	None	None	None
TNF	7124	ANESTHETICS	None	None	None
TNF	7124	AN0128	CHEMBL219629	CHEMBL219629	inhibitor
TNF	7124	ART621	PLACULUMAB	CHEMBL2108739	None
TNF	7124	ART621	PLACULUMAB	CHEMBL2108739	inhibitor
TNF	7124	AVX-470	None	None	None
TNF	7124	AZ-9773	AZ-9773	CHEMBL2109587	inhibitor
TNF	7124	BCG	None	None	None
TNF	7124	BETA-LAPACHONE	BETA-LAPACHONE	CHEMBL15192	None
TNF	7124	BUPIVACAINE	BUPIVACAINE	CHEMBL1098	None
TNF	7124	CELASTROL	CELASTROL	CHEMBL301982	None
TNF	7124	CERTOLIZUMAB	None	None	inhibitor
TNF	7124	CEFOTAXIME	CEFOTAXIME	CHEMBL1730	None
TNF	7124	CERTOLIZUMAB PEGOL	CERTOLIZUMAB PEGOL	CHEMBL1201831	inhibitor
TNF	7124	CGP41251	MIDOSTAURIN	CHEMBL608533	None
TNF	7124	CERTOLIZUMAB PEGOL	CERTOLIZUMAB PEGOL	CHEMBL1201831	None
TNF	7124	CARBAMAZEPINE	CARBAMAZEPINE	CHEMBL108	None
TNF	7124	CERTOLIZUMAB PEGOL	CERTOLIZUMAB PEGOL	CHEMBL1201831	None
TNF	7124	CERTOLIZUMAB PEGOL	CERTOLIZUMAB PEGOL	CHEMBL1201831	antibody
TNF	7124	CNTO 148	GOLIMUMAB	CHEMBL1201833	None
TNF	7124	COPTIS	None	None	None
TNF	7124	CRX-191	None	None	inhibitor
TNF	7124	CYTOFAB	NAFAMOSTAT	CHEMBL273264	antibody
TNF	7124	CYT007-TNFQB	None	None	None
TNF	7124	CYTOFAB	NAFAMOSTAT	CHEMBL273264	None
TNF	7124	DERSALAZINE	DERSALAZINE	CHEMBL2106406	None
TNF	7124	DIDANOSINE	DIDANOSINE	CHEMBL1460	None
TNF	7124	ESBA105	None	None	None
TNF	7124	ETANERCEPT	ETANERCEPT	CHEMBL1201572	inhibitor
TNF	7124	ETANERCEPT	ETANERCEPT	CHEMBL1201572	antibody
TNF	7124	ETANERCEPT	ETANERCEPT	CHEMBL1201572	None
TNF	7124	ETANERCEPT	ETANERCEPT	CHEMBL1201572	None
TNF	7124	FLUOCINOLONE ACETONIDE	FLUOCINOLONE ACETONIDE	CHEMBL989	None
TNF	7124	FOLIC ACID	FOLIC ACID	CHEMBL1622	None
TNF	7124	GENTAMICIN	GENTAMICIN	CHEMBL3039597	None
TNF	7124	GENZ29155	ORTATAXEL	CHEMBL382300	inhibitor
TNF	7124	GLIMEPIRIDE	GLIMEPIRIDE	CHEMBL1481	None
TNF	7124	GOLIMUMAB	GOLIMUMAB	CHEMBL1201833	None
TNF	7124	GOLIMUMAB	GOLIMUMAB	CHEMBL1201833	antibody
TNF	7124	GOLIMUMAB	GOLIMUMAB	CHEMBL1201833	None
TNF	7124	GOLIMUMAB	GOLIMUMAB	CHEMBL1201833	inhibitor
TNF	7124	HEXADECYLPHOSPHOCHOLINE	MILTEFOSINE	CHEMBL125	None
TNF	7124	HALOFUGINONE	HALOFUGINONE	CHEMBL1197091	None
TNF	7124	HORMONES	None	None	None
TNF	7124	HYDROXYCHLOROQUINE	HYDROXYCHLOROQUINE	CHEMBL1535	None
TNF	7124	IMMUNOSTIMULANT	None	None	None
TNF	7124	INFLIXIMAB	INFLIXIMAB	CHEMBL1201581	None
TNF	7124	INFLIXIMAB	INFLIXIMAB	CHEMBL1201581	antibody
TNF	7124	INFLIXIMAB	INFLIXIMAB	CHEMBL1201581	inhibitor
TNF	7124	INFLIXIMAB	INFLIXIMAB	CHEMBL1201581	None
TNF	7124	INSULIN	None	None	None
TNF	7124	ISIS-104838	None	None	None
TNF	7124	IP-751	AJULEMIC ACID	CHEMBL456341	inhibitor
TNF	7124	KW-2149	None	None	None
TNF	7124	LACTULOSE	LACTULOSE HYDRATE	CHEMBL1237068	None
TNF	7124	LENALIDOMIDE	LENALIDOMIDE	CHEMBL848	inhibitor
TNF	7124	LENALIDOMIDE	LENALIDOMIDE	CHEMBL848	None
TNF	7124	LENERCEPT	LENERCEPT	CHEMBL2108208	inhibitor
TNF	7124	MAGNESIUM SULFATE	MAGNESIUM SULFATE	CHEMBL1200456	None
TNF	7124	MEROPENEM	MEROPENEM	CHEMBL127	None
TNF	7124	METHIMAZOLE	METHIMAZOLE	CHEMBL1515	None
TNF	7124	MIDAZOLAM	MIDAZOLAM	CHEMBL655	None
TNF	7124	NERELIMOMAB	NERELIMOMAB	CHEMBL2108566	inhibitor
TNF	7124	NORDIHYDROGUAIARETIC ACID	NORDIHYDROGUAIARETIC ACID	CHEMBL52	None
TNF	7124	OK-432	PENICILLIN G SODIUM	CHEMBL1126	None
TNF	7124	OMEPRAZOLE	OMEPRAZOLE	CHEMBL1503	None
TNF	7124	ONERCEPT	ONERCEPT	CHEMBL2107911	inhibitor
TNF	7124	OZORALIZUMAB	OZORALIZUMAB	CHEMBL1743054	None
TNF	7124	OZORALIZUMAB	OZORALIZUMAB	CHEMBL1743054	inhibitor
TNF	7124	PCB	PROCARBAZINE	CHEMBL1321	None
TNF	7124	PEGSUNERCEPT	PEGSUNERCEPT	CHEMBL1743057	inhibitor
TNF	7124	PENTOXIFYLLINE	PENTOXIFYLLINE	CHEMBL628	antibody
TNF	7124	PF-04236921	PF-04236921	CHEMBL2109613	None
TNF	7124	PLACULUMAB	PLACULUMAB	CHEMBL2108739	inhibitor
TNF	7124	PNEUMOCOCCAL POLYSACCHARIDE VACCINE	None	None	None
TNF	7124	POLYPHENOL	None	None	None
TNF	7124	PIRFENIDONE	PIRFENIDONE	CHEMBL1256391	inhibitor
TNF	7124	PRAZOSIN HYDROCHLORIDE	PRAZOSIN HYDROCHLORIDE	CHEMBL1558	None
TNF	7124	PROTON PUMP INHIBITOR	None	None	None
TNF	7124	PYRIDOXINE	PYRIDOXINE	CHEMBL1364	None
TNF	7124	PROPYLTHIOURACIL	PROPYLTHIOURACIL	CHEMBL1518	None
TNF	7124	RABEPRAZOLE	RABEPRAZOLE	CHEMBL1219	None
TNF	7124	RDP58	DELMITIDE	CHEMBL2108587	inhibitor
TNF	7124	RDP-58	DELMITIDE	CHEMBL2108587	inhibitor
TNF	7124	RISPERIDONE	RISPERIDONE	CHEMBL85	None
TNF	7124	RUTIN	RUTIN	CHEMBL226335	None
TNF	7124	SODIUM CROMOGLYCATE	CROMOLYN SODIUM	CHEMBL74	None
TNF	7124	SPIRONOLACTONE	SPIRONOLACTONE	CHEMBL1393	None
TNF	7124	TALACTOFERRIN ALFA	TALACTOFERRIN ALFA	CHEMBL2108651	inhibitor
TNF	7124	TAXANES	None	None	None
TNF	7124	TETRANDRINE	None	None	None
TNF	7124	TGAAC94	URAPIDIL	CHEMBL279229	None
TNF	7124	TGAAC-94	URAPIDIL	CHEMBL279229	inhibitor
TNF	7124	THALIDOMIDE	THALIDOMIDE	CHEMBL468	inhibitor
TNF	7124	THALIDOMIDE	THALIDOMIDE	CHEMBL468	None
TNF	7124	THALIDOMIDE	THALIDOMIDE	CHEMBL468	None
TNF	7124	TIMOLOL MALEATE	TIMOLOL MALEATE	CHEMBL1200870	None
TNF	7124	TNF-ALPHA ADENOVECTOR	None	None	None
TNF	7124	TPA	PHORBOL MYRISTATE ACETATE	CHEMBL279115	None
TNF	7124	TZT-1027	None	None	None
TNF	7124	VADIMEZAN	VADIMEZAN	CHEMBL71263	inducer