ALTITUDEOMICSDB

Janus kinase 2

AltitudeomicsDB

Protein Official symbol	JAK2
Aliases	JAK2
Chromosomal Location	9
Length	1132
Uniprot ID	O60674
EC number	2.7.10.2
Protein family Information(Pfam)	PF18379;PF18377;PF17887;PF07714;PF00017;
PDB id	2B7A;2W1I;2XA4;3E62;3E63;3E64;3FUP;3IO7;3IOK;3JY9;3KCK;3KRR;3LPB;3Q32;3RVG;3TJC;3TJD;3UGC;3ZMM;4AQC;4BBE;4BBF;4C61;4C62;4D0W;4D0X;4D1S;4E4M;4E6D;4E6Q;4F08;4F09;4FVP;4FVQ;4FVR;4GFM;4GMY;4HGE;4IVA;4JI9;4JIA;4P7E;4YTC;4YTF;4YTH;4YTI;4Z32;4ZIM;5AEP;5CF4;5CF5;5CF6;5CF8;5HEZ;5I4N;5L3A;5TQ3;5TQ4;5TQ5;5TQ6;5TQ7;5TQ8;5USY;5USZ;5UT0;5UT1;5UT2;5UT3;5UT4;5UT5;5UT6;5WEV;5WIJ;5WIK;5WIL;5WIM;5WIN;6AAJ;6BBV;6BRW;6BS0;6BSS;6D2I;6DRW;6E2P;6E2Q;6G3C;6M9H;6OAV;6OBB;6OBF;6OBL;6OCC;
InterPro ID	IPR019749;IPR035963;IPR000299;IPR041155;IPR041046;IPR041381;IPR037838;IPR035860;IPR011009;IPR000719;IPR017441;IPR035588;IPR035589;IPR001245;IPR000980;IPR036860;IPR008266;IPR020635;IPR016251;IPR020693;
dbSNP	rs56118985 rs55667734 rs55953208 rs2230723 rs121912473 rs17490221 rs121912472 rs77375493 rs77375493 rs41316003

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
JAK2	STAT5B	0.9990000000000001
PRLR	PRL	0.9990000000000001
SHC1	GRB2	0.9990000000000001
EPO	EPOR	0.9990000000000001
PTPN11	IRS1	0.9990000000000001
HRAS	RAF1	0.9990000000000001
JAK2	STAT5A	0.9990000000000001
JAK2	STAT3	0.998
CXCR4	CXCL12	0.998
JAK2	STAT1	0.998
LEPR	LEP	0.998
IL6	IL6ST	0.997
IL6	STAT3	0.997
MPL	THPO	0.996
CSF2RB	CSF2	0.996
SOCS3	STAT3	0.995
KRAS	RAF1	0.995
JAK2	EPOR	0.995
CSF2	IL3	0.995
HRAS	KRAS	0.995
JAK2	SOCS3	0.9940000000000001
IL4R	STAT6	0.993
JAK2	PTPN1	0.993
PIK3R1	IRS1	0.992
JAK2	PTPN11	0.992
GRB2	IRS1	0.992
LEP	STAT3	0.992
IL6	SOCS3	0.992
JAK2	SOCS1	0.992
PIK3R1	SHC1	0.992
JAK2	STAT2	0.992
PTPN11	STAT3	0.991
IFNGR1	IFNGR2	0.991
JAK2	MPL	0.991
LEPR	SOCS3	0.99
JAK2	LEPR	0.99
PTPN1	IRS1	0.99
LEPR	STAT3	0.99
IFNGR1	STAT1	0.99
SHC1	IRS1	0.9890000000000001
STAT5A	EPOR	0.9890000000000001
GRB2	PTPN11	0.9890000000000001
GHR	JAK2	0.9890000000000001
HRAS	GRB2	0.9890000000000001
SOCS3	LEP	0.9890000000000001
PRLR	STAT5B	0.988
JAK2	EPO	0.988
PTPN11	SOCS3	0.987
IL6ST	STAT3	0.987
IL23R	STAT3	0.987
PRLR	STAT5A	0.987
PIK3R1	HRAS	0.987
SOCS3	IRS1	0.987
STAT5A	PRL	0.986
STAT1	SOCS3	0.986
STAT1	PTPN11	0.986
GRB2	JAK2	0.986
GRB2	KRAS	0.985
PTPN2	STAT3	0.985
JAK2	IRS1	0.985
SOCS2	JAK2	0.9840000000000001
STAT1	PTPN2	0.9840000000000001
STAT4	JAK2	0.9840000000000001
JAK2	LEP	0.9840000000000001
CISH	STAT5A	0.9840000000000001
SOCS1	STAT3	0.9840000000000001
IL3	STAT5B	0.9840000000000001
PRL	STAT5B	0.983
GHR	STAT5B	0.983
STAT5A	IL3	0.983
PTPN2	STAT5B	0.983
IL6	STAT1	0.983
PTPN6	JAK2	0.983
STAT5A	PTPN2	0.983
SOCS2	STAT5A	0.983
LEP	IRS1	0.982
CISH	STAT5B	0.982
JAK2	STAT6	0.982
HRAS	PTPN11	0.982
GHR	STAT5A	0.982
STAT5B	EPOR	0.982
GRB2	PTPN1	0.982
JAK2	SOCS5	0.982
JAK2	IRS2	0.982
SOCS2	STAT5B	0.982
STAT5A	CSF2	0.981
CXCR4	STAT3	0.981
PRLR	JAK2	0.981
IL6	STAT6	0.981
CSF2	STAT5B	0.981
HRAS	JAK2	0.981
PIK3R1	IRS2	0.98
JAK2	IL23R	0.98
PTPN1	LEP	0.98
JAK2	PRL	0.98
JAK2	IFNGR1	0.9790000000000001
JAK2	SH2B3	0.9790000000000001
CSF2	STAT3	0.9790000000000001
PIK3R1	STAT3	0.978
PTPN6	STAT5B	0.978
CSF2RB	IL3	0.978
SOCS1	IRS1	0.977
STAT5A	EPO	0.976
JAK2	CDKN1B	0.976
SHC1	IRS2	0.976
STAT5A	STAT3	0.976
JAK2	IFNGR2	0.976
SHC1	JAK2	0.976
JAK2	PRMT5	0.976
IL4R	SOCS5	0.976
PTPN11	KRAS	0.976
PTPN1	LEPR	0.975
CXCR4	JAK2	0.975
STAT1	STAT5A	0.975
IL6	JAK2	0.975
PIK3R1	GRB2	0.975
SHC1	MPL	0.975
JAK2	SH2B1	0.975
STAT5B	EPO	0.9740000000000001
PTPN6	IRS1	0.9740000000000001
STAT5A	SOCS3	0.973
SOCS3	STAT5B	0.973
PTPN2	STAT6	0.973
SOCS1	STAT6	0.973
GHR	SOCS3	0.973
CISH	JAK2	0.973
CXCL12	STAT3	0.972
PIK3R1	PTPN11	0.972
PTPN1	STAT5A	0.972
STAT1	STAT3	0.972
CISH	STAT3	0.972
PTPN1	STAT5B	0.972
IFNGR1	SOCS1	0.972
STAT1	STAT2	0.971
PTPN6	STAT5A	0.971
GHR	SOCS2	0.97
STAT5A	SOCS1	0.97
GHR	CISH	0.9690000000000001
PTPN11	CSF2	0.9690000000000001
SOCS1	STAT5B	0.9690000000000001
SOCS3	SOCS5	0.9690000000000001
IL6ST	SOCS3	0.968
IL4R	STAT3	0.968
SHC1	KRAS	0.9670000000000001
IL6ST	STAT1	0.9670000000000001
GRB2	SOCS1	0.966
CSF2RB	STAT5A	0.966
EPO	THPO	0.966
SOCS3	STAT6	0.966
CSF2RB	JAK2	0.966
IRS2	LEP	0.966
JAK2	IL3	0.966
STAT4	IL23R	0.966
JAK2	THPO	0.965
SOCS1	STAT2	0.965
GRB2	EPOR	0.965
JAK2	IL6ST	0.965
SOCS3	STAT2	0.965
IL6ST	PTPN11	0.965
HRAS	SHC1	0.965
PIK3R1	JAK2	0.9640000000000001
JAK2	PTPN2	0.9640000000000001
JAK2	BCR	0.963
SOCS3	EPO	0.963
SOCS3	EPOR	0.963
HRAS	IL3	0.963
SHC1	PTPN11	0.9620000000000001
JAK2	KRAS	0.9620000000000001
JAK2	CSF2	0.9620000000000001
JAK2	NFKBIA	0.9620000000000001
MPL	STAT5B	0.9620000000000001
MPL	STAT5A	0.9620000000000001
STAT1	CSF2	0.9620000000000001
PTPN6	STAT6	0.9620000000000001
CXCL12	JAK2	0.9620000000000001
GHR	PRL	0.9620000000000001
IL4R	JAK2	0.9620000000000001
JAK2	RAF1	0.9620000000000001
CXCR4	STAT1	0.961
SHC1	PTPN6	0.961
LEP	PRL	0.961
STAT5B	STAT3	0.961
GHR	IRS1	0.96
STAT5B	THPO	0.96
PTPN11	STAT2	0.9590000000000001
GRB2	IRS2	0.9590000000000001
GRB2	STAT3	0.9590000000000001
IL6	CSF2	0.9590000000000001
GHR	STAT3	0.958
IRS2	SOCS3	0.958
STAT1	SOCS1	0.9570000000000001
STAT5A	THPO	0.9570000000000001
HRAS	IRS1	0.9570000000000001
SHC1	EPOR	0.956
PIK3R1	PTPN6	0.956
IRS1	KRAS	0.955
GRB2	BCR	0.955
CXCR4	STAT5B	0.955
IL6	PTPN11	0.9540000000000001
PTPN6	EPOR	0.9540000000000001
STAT4	IL6ST	0.9540000000000001
IL4R	IRS2	0.9540000000000001
SOCS5	STAT6	0.9540000000000001
PIK3R1	NFKBIA	0.953
SH2B3	EPOR	0.953
GHR	PIK3R1	0.953
PRL	STAT3	0.953
IRS2	IRS1	0.953
SOCS2	SOCS3	0.9520000000000001
PIK3R1	KRAS	0.9520000000000001
PTPN6	CSF2RB	0.951
IFNGR1	PTPN11	0.95
SHC1	PTPN2	0.95
IL4R	STAT5A	0.95
GHR	SOCS1	0.9490000000000001
STAT1	IL23R	0.9490000000000001
STAT2	STAT3	0.9490000000000001
STAT5A	STAT5B	0.9490000000000001
SOCS3	KRAS	0.948
IL4R	STAT1	0.948
PRLR	PTPN11	0.948
IL4R	IRS1	0.948
PTPN11	IL3	0.9470000000000001
CXCR4	STAT2	0.9470000000000001
LEP	STAT5B	0.946
STAT5A	LEP	0.946
SHC1	IL4R	0.946
HRAS	SOCS3	0.946
CXCR4	PTPN11	0.946
CISH	STAT1	0.946
SHC1	CSF2RB	0.946
PTPN11	LEP	0.945
IFNGR1	SOCS3	0.945
HRAS	CSF2	0.945
STAT4	STAT1	0.945
IL4R	STAT5B	0.945
STAT5A	IL23R	0.945
STAT3	THPO	0.9440000000000001
GRB2	SH2B3	0.9440000000000001
HRAS	SOCS1	0.9440000000000001
IRS2	EPOR	0.9440000000000001
IL4R	SOCS1	0.9440000000000001
IL6	LEP	0.943
STAT1	STAT5B	0.943
MPL	STAT3	0.943
BCR	STAT5B	0.943
GRB2	IL6ST	0.943
PTPN6	IL4R	0.943
STAT5A	BCR	0.9420000000000001
PRLR	STAT3	0.9420000000000001
GRB2	IL3	0.9420000000000001
SHC1	IL3	0.9420000000000001
IL6ST	STAT2	0.9420000000000001
STAT1	PRL	0.941
CSF2RB	STAT5B	0.941
CSF2	KRAS	0.941
PTPN6	CXCR4	0.941
STAT1	EPO	0.941
SH2B3	EPO	0.94
SOCS2	CISH	0.94
SHC1	BCR	0.94
CSF2RB	STAT3	0.94
CXCR4	STAT5A	0.94
IFNGR1	PTPN2	0.9390000000000001
SHC1	PTPN1	0.9390000000000001
IL6	GRB2	0.9390000000000001
CSF2RB	PTPN11	0.9390000000000001
CSF2RB	STAT1	0.938
STAT4	STAT3	0.938
IL6ST	STAT5A	0.938
HRAS	CXCL12	0.938
PRLR	STAT1	0.937
IL23R	STAT6	0.937
HRAS	IRS2	0.937
IRS2	PTPN11	0.937
PTPN6	PTPN11	0.937
PTPN6	BCR	0.9359999999999999
GRB2	PTPN2	0.9359999999999999
IRS2	PTPN1	0.9359999999999999
PIK3R1	BCR	0.935
SOCS1	IFNGR2	0.935
STAT2	CSF2	0.935
IRS2	KRAS	0.935
STAT1	EPOR	0.935
IRS1	PRL	0.934
SOCS3	IL23R	0.934
CXCL12	STAT1	0.9329999999999999
STAT1	IFNGR2	0.9329999999999999
IL3	KRAS	0.932
CXCL12	STAT5A	0.932
SHC1	THPO	0.932
PRLR	CISH	0.932
GRB2	EPO	0.932
GHR	PTPN1	0.932
IL23R	NFKBIA	0.932
CXCL12	STAT5B	0.9309999999999999
STAT6	STAT3	0.9309999999999999
STAT1	STAT6	0.9309999999999999
GHR	PTPN6	0.93
SOCS3	SOCS1	0.93
STAT1	THPO	0.929
GHR	IRS2	0.929
PTPN6	STAT2	0.929
CISH	STAT6	0.929
PTPN6	SOCS3	0.929
SHC1	IL6	0.929
IRS2	PRL	0.929
PIK3R1	CSF2RB	0.9279999999999999
MPL	STAT1	0.9279999999999999
PRLR	IRS2	0.9279999999999999
GHR	STAT1	0.927
PIK3R1	PTPN1	0.927
STAT5A	STAT2	0.927
SH2B3	SOCS3	0.927
SHC1	EPO	0.9259999999999999
SOCS3	IFNGR2	0.9259999999999999
CISH	SOCS3	0.9259999999999999
CISH	STAT2	0.9259999999999999
PTPN11	PRL	0.9259999999999999
GRB2	CSF2	0.9259999999999999
STAT2	STAT5B	0.925
SHC1	CSF2	0.925
GRB2	MPL	0.925
CISH	STAT4	0.925
SOCS1	SOCS5	0.924
CISH	SOCS5	0.924
PTPN6	IL3	0.9229999999999999
GHR	PRLR	0.922
IL6	IL23R	0.922
PTPN1	STAT2	0.9209999999999999
PTPN1	IFNGR1	0.92
STAT4	STAT5A	0.92
PIK3R1	IL3	0.92
CXCL12	PTPN11	0.919
BCR	STAT3	0.919
PIK3R1	CXCR4	0.919
SOCS2	SOCS5	0.919
PTPN6	CXCL12	0.9179999999999999
IRS2	EPO	0.9179999999999999
PTPN6	EPO	0.9179999999999999
STAT4	STAT5B	0.9179999999999999
PTPN6	PTPN2	0.9179999999999999
GRB2	THPO	0.9179999999999999
PRLR	IRS1	0.917
IL3	EPO	0.915
PIK3R1	CXCL12	0.915
PTPN6	IFNGR1	0.915
PTPN6	CSF2	0.914
IRS2	SOCS1	0.914
SH2B1	IRS1	0.9129999999999999
PTPN11	IFNGR2	0.912
IL4R	GRB2	0.9109999999999999
CSF2RB	GRB2	0.9109999999999999
CSF2RB	STAT2	0.91
CXCL12	RAF1	0.91
CXCL12	STAT2	0.91
PIK3R1	THPO	0.909
STAT4	STAT2	0.909
PRL	EPO	0.9079999999999999
STAT2	STAT6	0.9079999999999999
STAT1	BCR	0.907
PIK3R1	CSF2	0.9059999999999999
PTPN1	IFNGR2	0.9059999999999999
HRAS	CSF2RB	0.904
PIK3R1	IFNGR1	0.904
SOCS5	STAT5B	0.904
PIK3R1	MPL	0.904
STAT5A	SOCS5	0.904
CSF2RB	KRAS	0.903
PIK3R1	IL4R	0.903
PTPN6	IFNGR2	0.903
PIK3R1	STAT6	0.903
PIK3R1	IL23R	0.9

Gene Ontology Semantic Similarity

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#	3717 (JAK2)	5618 (PRLR)	6464 (SHC1)	2056 (EPO)	5781 (PTPN11)	3265 (HRAS)	7852 (CXCR4)	3953 (LEPR)	3569 (IL6)	4352 (MPL)	1439 (CSF2RB)	9021 (SOCS3)	3845 (KRAS)	1437 (CSF2)	3566 (IL4R)	5295 (PIK3R1)	2885 (GRB2)	3952 (LEP)	3459 (IFNGR1)	5770 (PTPN1)	6776 (STAT5A)	2690 (GHR)	3572 (IL6ST)	149233 (IL23R)	6772 (STAT1)	5771 (PTPN2)	8835 (SOCS2)	6775 (STAT4)	1154 (CISH)	8651 (SOCS1)	3562 (IL3)	5617 (PRL)	5777 (PTPN6)	6777 (STAT5B)	6387 (CXCL12)	8660 (IRS2)	3667 (IRS1)	9655 (SOCS5)	10019 (SH2B3)	6773 (STAT2)	6774 (STAT3)	613 (BCR)	6778 (STAT6)	25970 (SH2B1)	2057 (EPOR)	5894 (RAF1)	7066 (THPO)	3460 (IFNGR2)	1027 (CDKN1B)	10419 (PRMT5)	4792 (NFKBIA)
3717 (JAK2)	1.00	0.48	0.62	1.00	0.55	0.47	0.48	0.46	0.58	0.46	0.71	0.49	0.52	0.81	0.47	0.64	0.78	0.43	0.48	0.58	0.74	0.57	0.48	0.55	0.53	0.56	0.57	1.00	0.52	0.55	0.75	0.54	0.51	0.70	0.51	0.68	0.72	0.51	1.00	0.53	0.52	0.72	0.48	1.00	0.50	0.76	0.84	0.09	0.52	0.46	0.56
5618 (PRLR)	0.48	1.00	0.54	1.00	0.39	0.45	0.64	0.70	0.58	0.70	0.60	0.53	0.57	0.48	0.63	0.58	0.52	0.41	0.65	0.53	0.49	0.77	0.73	0.66	0.54	0.52	0.55	1.00	0.54	0.55	0.39	0.55	0.54	0.51	0.46	0.49	0.52	0.53	1.00	0.60	0.52	0.50	0.50	1.00	0.71	0.48	0.69	0.39	0.55	0.35	0.66
6464 (SHC1)	0.62	0.54	1.00	1.00	0.52	0.54	0.54	0.53	0.63	0.53	0.57	0.57	0.63	0.65	0.54	0.74	0.74	0.52	0.56	0.63	0.56	0.61	0.51	0.58	0.54	0.63	0.63	1.00	0.57	0.62	0.60	0.61	0.54	0.55	0.58	0.66	0.76	0.61	1.00	0.62	0.51	0.52	0.54	1.00	0.58	0.53	0.70	0.10	0.56	0.43	0.63
2056 (EPO)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	0.13	1.00	1.00	1.00
5781 (PTPN11)	0.55	0.39	0.52	1.00	1.00	0.41	0.43	0.37	0.47	0.37	0.42	0.39	0.48	0.49	0.37	0.66	0.67	0.34	0.39	0.65	0.52	0.47	0.40	0.42	0.44	0.70	0.50	1.00	0.44	0.41	0.44	0.43	0.69	0.52	0.41	0.70	0.68	0.40	1.00	0.45	0.44	0.52	0.41	1.00	0.43	0.58	0.69	0.08	0.43	0.37	0.52
3265 (HRAS)	0.47	0.45	0.54	1.00	0.41	1.00	0.49	0.44	0.58	0.44	0.38	0.48	0.57	0.45	0.46	0.52	0.51	0.41	0.48	0.55	0.48	0.57	0.44	0.51	0.50	0.53	0.52	1.00	0.50	0.48	0.37	0.55	0.47	0.49	0.45	0.45	0.49	0.49	1.00	0.58	0.47	0.42	0.48	1.00	0.53	0.47	0.69	0.09	0.47	0.39	0.61
7852 (CXCR4)	0.48	0.64	0.54	1.00	0.43	0.49	1.00	0.75	0.58	0.75	0.64	0.52	0.57	0.50	0.68	0.53	0.52	0.40	0.69	0.55	0.52	0.57	0.68	0.69	0.52	0.53	0.54	1.00	0.54	0.51	0.38	0.56	0.60	0.52	0.47	0.54	0.55	0.52	1.00	0.58	0.52	0.47	0.51	1.00	0.72	0.51	0.69	0.34	0.52	0.40	0.66
3953 (LEPR)	0.46	0.70	0.53	1.00	0.37	0.44	0.75	1.00	0.60	0.94	0.68	0.48	0.60	0.44	0.80	0.52	0.50	0.44	0.84	0.53	0.48	0.59	0.77	0.81	0.50	0.52	0.52	1.00	0.51	0.48	0.38	0.58	0.64	0.50	0.48	0.51	0.53	0.48	1.00	0.62	0.50	0.39	0.48	1.00	0.87	0.47	0.69	0.66	0.49	0.33	0.64
3569 (IL6)	0.58	0.58	0.63	1.00	0.47	0.58	0.58	0.60	1.00	0.60	0.48	0.67	0.77	0.61	0.62	0.58	0.58	0.66	0.67	0.62	0.67	0.70	0.58	0.72	0.57	0.64	0.67	1.00	0.65	0.62	0.67	0.78	0.59	0.61	0.68	0.55	0.57	0.65	1.00	0.79	0.52	0.55	0.60	1.00	0.69	0.55	1.00	0.11	0.56	0.42	0.73
4352 (MPL)	0.46	0.70	0.53	1.00	0.37	0.44	0.75	0.94	0.60	1.00	0.68	0.48	0.60	0.44	0.80	0.52	0.50	0.44	0.84	0.53	0.48	0.59	0.77	0.81	0.50	0.52	0.52	1.00	0.51	0.48	0.38	0.58	0.64	0.50	0.48	0.51	0.53	0.48	1.00	0.62	0.50	0.39	0.48	1.00	0.87	0.47	0.69	0.66	0.49	0.33	0.64
1439 (CSF2RB)	0.71	0.60	0.57	1.00	0.42	0.38	0.64	0.68	0.48	0.68	1.00	0.39	0.45	0.73	0.61	0.55	0.65	0.32	0.62	0.46	0.59	0.48	0.67	0.64	0.45	0.44	0.45	1.00	0.47	0.43	0.63	0.43	0.49	0.57	0.41	0.66	0.63	0.40	1.00	0.46	0.46	0.58	0.41	1.00	0.67	0.63	0.69	0.49	0.45	0.34	0.54
9021 (SOCS3)	0.49	0.53	0.57	1.00	0.39	0.48	0.52	0.48	0.67	0.48	0.39	1.00	0.71	0.52	0.50	0.59	0.53	0.52	0.56	0.57	0.56	0.65	0.46	0.58	0.52	0.57	0.83	1.00	0.90	0.87	0.43	0.68	0.49	0.54	0.52	0.49	0.52	0.90	1.00	0.74	0.48	0.48	0.52	1.00	0.62	0.49	0.69	0.11	0.73	0.35	0.69
3845 (KRAS)	0.52	0.57	0.63	1.00	0.48	0.57	0.57	0.60	0.77	0.60	0.45	0.71	1.00	0.61	0.62	0.59	0.56	0.62	0.71	0.62	0.71	0.73	0.50	0.68	0.56	0.67	0.66	1.00	0.66	0.61	0.47	0.83	0.59	0.62	0.58	0.58	0.58	0.67	1.00	0.88	0.51	0.53	0.59	1.00	0.73	0.55	0.69	0.12	0.60	0.40	0.76
1437 (CSF2)	0.81	0.48	0.65	1.00	0.49	0.45	0.50	0.44	0.61	0.44	0.73	0.52	0.61	1.00	0.46	0.61	0.73	0.44	0.49	0.54	0.84	0.59	0.44	0.53	0.50	0.53	0.55	1.00	0.55	0.53	0.81	0.59	0.45	0.70	0.49	0.74	0.69	0.51	1.00	0.63	0.47	0.75	0.49	1.00	0.55	0.75	0.69	0.11	0.50	0.38	0.64
3566 (IL4R)	0.47	0.63	0.54	1.00	0.37	0.46	0.68	0.80	0.62	0.80	0.61	0.50	0.62	0.46	1.00	0.53	0.51	0.45	0.74	0.54	0.50	0.60	0.72	0.73	0.50	0.53	0.54	1.00	0.55	0.50	0.39	0.60	0.57	0.51	0.49	0.57	0.57	0.50	1.00	0.64	0.54	0.41	0.49	1.00	0.78	0.52	0.69	0.55	0.58	0.34	0.65
5295 (PIK3R1)	0.64	0.58	0.74	1.00	0.66	0.52	0.53	0.52	0.58	0.52	0.55	0.59	0.59	0.61	0.53	1.00	0.75	0.45	0.54	0.58	0.61	0.61	0.50	0.55	0.53	0.59	0.63	1.00	0.59	0.65	0.52	0.57	0.53	0.59	0.53	0.74	0.80	0.62	1.00	0.58	0.55	0.63	0.56	1.00	0.55	0.63	0.70	0.10	0.62	0.47	0.63
2885 (GRB2)	0.78	0.52	0.74	1.00	0.67	0.51	0.52	0.50	0.58	0.50	0.65	0.53	0.56	0.73	0.51	0.75	1.00	0.42	0.52	0.66	0.67	0.61	0.50	0.54	0.58	0.58	0.59	1.00	0.55	0.58	0.62	0.56	0.55	0.64	0.50	0.75	0.78	0.55	1.00	0.59	0.58	0.66	0.54	1.00	0.56	0.71	0.70	0.09	0.55	0.48	0.61
3952 (LEP)	0.43	0.41	0.52	0.69	0.34	0.41	0.40	0.44	0.66	0.44	0.32	0.52	0.62	0.44	0.45	0.45	0.42	1.00	0.52	0.47	0.52	0.52	0.38	0.51	0.44	0.50	0.55	0.69	0.48	0.47	0.47	0.65	0.42	0.46	0.59	0.41	0.43	0.52	0.69	0.63	0.35	0.38	0.42	0.69	0.53	0.38	0.70	0.08	0.38	0.28	0.53
3459 (IFNGR1)	0.48	0.65	0.56	1.00	0.39	0.48	0.69	0.84	0.67	0.84	0.62	0.56	0.71	0.49	0.74	0.54	0.52	0.52	1.00	0.57	0.56	0.65	0.72	0.78	0.52	0.57	0.58	1.00	0.56	0.53	0.41	0.68	0.60	0.54	0.51	0.50	0.53	0.55	1.00	0.73	0.49	0.43	0.52	1.00	0.85	0.49	0.69	0.71	0.50	0.35	0.69
5770 (PTPN1)	0.58	0.53	0.63	1.00	0.65	0.55	0.55	0.53	0.62	0.53	0.46	0.57	0.62	0.54	0.54	0.58	0.66	0.47	0.57	1.00	0.57	0.68	0.50	0.57	0.64	0.81	0.58	1.00	0.57	0.62	0.43	0.61	0.79	0.55	0.53	0.52	0.59	0.66	1.00	0.63	0.60	0.51	0.56	1.00	0.59	0.59	0.70	0.09	0.59	0.45	0.68
6776 (STAT5A)	0.74	0.49	0.56	1.00	0.52	0.48	0.52	0.48	0.67	0.48	0.59	0.56	0.71	0.84	0.50	0.61	0.67	0.52	0.56	0.57	1.00	0.65	0.46	0.58	0.52	0.57	0.58	1.00	0.57	0.53	0.67	0.68	0.49	0.76	0.52	0.62	0.61	0.55	1.00	0.74	0.48	0.81	0.52	1.00	0.62	0.80	0.69	0.11	0.49	0.39	0.69
2690 (GHR)	0.57	0.77	0.61	1.00	0.47	0.57	0.57	0.59	0.70	0.59	0.48	0.65	0.73	0.59	0.60	0.61	0.61	0.52	0.65	0.68	0.65	1.00	0.56	0.64	0.62	0.71	0.63	1.00	0.63	0.68	0.44	0.72	0.67	0.61	0.54	0.55	0.60	0.67	1.00	0.77	0.59	0.54	0.60	1.00	0.69	0.61	0.69	0.11	0.61	0.42	0.76
3572 (IL6ST)	0.48	0.73	0.51	1.00	0.40	0.44	0.68	0.77	0.58	0.77	0.67	0.46	0.50	0.44	0.72	0.50	0.50	0.38	0.72	0.50	0.46	0.56	1.00	0.77	0.52	0.48	0.50	1.00	0.49	0.46	0.41	0.52	0.58	0.48	0.48	0.51	0.53	0.46	1.00	0.52	0.53	0.42	0.47	1.00	0.77	0.46	0.69	0.45	0.48	0.37	0.56
149233 (IL23R)	0.55	0.66	0.58	1.00	0.42	0.51	0.69	0.81	0.72	0.81	0.64	0.58	0.68	0.53	0.73	0.55	0.54	0.51	0.78	0.57	0.58	0.64	0.77	1.00	0.54	0.58	0.60	1.00	0.58	0.55	0.51	0.69	0.61	0.55	0.55	0.53	0.54	0.57	1.00	0.70	0.51	0.48	0.54	1.00	0.81	0.51	0.69	0.43	0.52	0.38	0.68
6772 (STAT1)	0.53	0.54	0.54	1.00	0.44	0.50	0.52	0.50	0.57	0.50	0.45	0.52	0.56	0.50	0.50	0.53	0.58	0.44	0.52	0.64	0.52	0.62	0.52	0.54	1.00	0.54	0.55	1.00	0.54	0.52	0.40	0.56	0.51	0.66	0.49	0.50	0.52	0.52	1.00	0.61	0.79	0.48	0.81	1.00	0.57	0.54	0.69	0.09	0.51	0.52	0.65
5771 (PTPN2)	0.56	0.52	0.63	1.00	0.70	0.53	0.53	0.52	0.64	0.52	0.44	0.57	0.67	0.53	0.53	0.59	0.58	0.50	0.57	0.81	0.57	0.71	0.48	0.58	0.54	1.00	0.58	1.00	0.57	0.64	0.44	0.63	0.85	0.55	0.54	0.54	0.62	0.69	1.00	0.65	0.54	0.49	0.54	1.00	0.60	0.57	0.69	0.09	0.60	0.40	0.67
8835 (SOCS2)	0.57	0.55	0.63	1.00	0.50	0.52	0.54	0.52	0.67	0.52	0.45	0.83	0.66	0.55	0.54	0.63	0.59	0.55	0.58	0.58	0.58	0.63	0.50	0.60	0.55	0.58	1.00	1.00	0.78	0.85	0.49	0.67	0.53	0.55	0.57	0.52	0.58	0.79	1.00	0.67	0.50	0.52	0.54	1.00	0.61	0.51	0.70	0.10	0.70	0.39	0.67
6775 (STAT4)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	0.13	1.00	1.00	1.00
1154 (CISH)	0.52	0.54	0.57	1.00	0.44	0.50	0.54	0.51	0.65	0.51	0.47	0.90	0.66	0.55	0.55	0.59	0.55	0.48	0.56	0.57	0.57	0.63	0.49	0.58	0.54	0.57	0.78	1.00	1.00	0.82	0.46	0.64	0.51	0.57	0.57	0.57	0.57	0.83	1.00	0.68	0.53	0.51	0.56	1.00	0.61	0.52	0.69	0.17	0.72	0.40	0.67
8651 (SOCS1)	0.55	0.55	0.62	1.00	0.41	0.48	0.51	0.48	0.62	0.48	0.43	0.87	0.61	0.53	0.50	0.65	0.58	0.47	0.53	0.62	0.53	0.68	0.46	0.55	0.52	0.64	0.85	1.00	0.82	1.00	0.45	0.60	0.58	0.52	0.52	0.51	0.61	0.87	1.00	0.63	0.52	0.51	0.51	1.00	0.57	0.53	0.70	0.10	0.78	0.37	0.65
3562 (IL3)	0.75	0.39	0.60	0.69	0.44	0.37	0.38	0.38	0.67	0.38	0.63	0.43	0.47	0.81	0.39	0.52	0.62	0.47	0.41	0.43	0.67	0.44	0.41	0.51	0.40	0.44	0.49	0.69	0.46	0.45	1.00	0.53	0.38	0.57	0.55	0.63	0.58	0.45	0.69	0.48	0.35	0.63	0.38	0.69	0.43	0.61	0.70	0.09	0.39	0.33	0.46
5617 (PRL)	0.54	0.55	0.61	1.00	0.43	0.55	0.56	0.58	0.78	0.58	0.43	0.68	0.83	0.59	0.60	0.57	0.56	0.65	0.68	0.61	0.68	0.72	0.52	0.69	0.56	0.63	0.67	1.00	0.64	0.60	0.53	1.00	0.57	0.60	0.64	0.53	0.55	0.64	1.00	0.85	0.50	0.51	0.58	1.00	0.71	0.53	0.69	0.12	0.54	0.38	0.74
5777 (PTPN6)	0.51	0.54	0.54	1.00	0.69	0.47	0.60	0.64	0.59	0.64	0.49	0.49	0.59	0.45	0.57	0.53	0.55	0.42	0.60	0.79	0.49	0.67	0.58	0.61	0.51	0.85	0.53	1.00	0.51	0.58	0.38	0.57	1.00	0.50	0.47	0.47	0.55	0.54	1.00	0.61	0.51	0.42	0.49	1.00	0.64	0.53	0.69	0.28	0.54	0.35	0.64
6777 (STAT5B)	0.70	0.51	0.55	1.00	0.52	0.49	0.52	0.50	0.61	0.50	0.57	0.54	0.62	0.70	0.51	0.59	0.64	0.46	0.54	0.55	0.76	0.61	0.48	0.55	0.66	0.55	0.55	1.00	0.57	0.52	0.57	0.60	0.50	1.00	0.51	0.59	0.59	0.53	1.00	0.62	0.65	0.69	0.68	1.00	0.57	0.72	0.69	0.11	0.51	0.45	0.64
6387 (CXCL12)	0.51	0.46	0.58	0.82	0.41	0.45	0.47	0.48	0.68	0.48	0.41	0.52	0.58	0.49	0.49	0.53	0.50	0.59	0.51	0.53	0.52	0.54	0.48	0.55	0.49	0.54	0.57	0.82	0.57	0.52	0.55	0.64	0.47	0.51	1.00	0.49	0.51	0.53	0.82	0.59	0.44	0.45	0.48	0.82	0.53	0.46	0.84	0.11	0.46	0.36	0.56
8660 (IRS2)	0.68	0.49	0.66	1.00	0.70	0.45	0.54	0.51	0.55	0.51	0.66	0.49	0.58	0.74	0.57	0.74	0.75	0.41	0.50	0.52	0.62	0.55	0.51	0.53	0.50	0.54	0.52	1.00	0.57	0.51	0.63	0.53	0.47	0.59	0.49	1.00	0.89	0.49	1.00	0.55	0.54	0.61	0.49	1.00	0.54	0.64	0.69	0.18	0.55	0.40	0.59
3667 (IRS1)	0.72	0.52	0.76	1.00	0.68	0.49	0.55	0.53	0.57	0.53	0.63	0.52	0.58	0.69	0.57	0.80	0.78	0.43	0.53	0.59	0.61	0.60	0.53	0.54	0.52	0.62	0.58	1.00	0.57	0.61	0.58	0.55	0.55	0.59	0.51	0.89	1.00	0.57	1.00	0.56	0.58	0.60	0.51	1.00	0.55	0.65	0.70	0.15	0.59	0.44	0.59
9655 (SOCS5)	0.51	0.53	0.61	1.00	0.40	0.49	0.52	0.48	0.65	0.48	0.40	0.90	0.67	0.51	0.50	0.62	0.55	0.52	0.55	0.66	0.55	0.67	0.46	0.57	0.52	0.69	0.79	1.00	0.83	0.87	0.45	0.64	0.54	0.53	0.53	0.49	0.57	1.00	1.00	0.69	0.50	0.48	0.52	1.00	0.59	0.51	0.69	0.10	0.74	0.36	0.68
10019 (SH2B3)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	0.13	1.00	1.00	1.00
6773 (STAT2)	0.53	0.60	0.62	1.00	0.45	0.58	0.58	0.62	0.79	0.62	0.46	0.74	0.88	0.63	0.64	0.58	0.59	0.63	0.73	0.63	0.74	0.77	0.52	0.70	0.61	0.65	0.67	1.00	0.68	0.63	0.48	0.85	0.61	0.62	0.59	0.55	0.56	0.69	1.00	1.00	0.54	0.55	0.65	1.00	0.83	0.59	0.69	0.12	0.56	0.40	0.81
6774 (STAT3)	0.52	0.52	0.51	1.00	0.44	0.47	0.52	0.50	0.52	0.50	0.46	0.48	0.51	0.47	0.54	0.55	0.58	0.35	0.49	0.60	0.48	0.59	0.53	0.51	0.79	0.54	0.50	1.00	0.53	0.52	0.35	0.50	0.51	0.65	0.44	0.54	0.58	0.50	1.00	0.54	1.00	0.45	0.80	1.00	0.54	0.53	0.69	0.14	0.57	0.50	0.60
613 (BCR)	0.72	0.50	0.52	1.00	0.52	0.42	0.47	0.39	0.55	0.39	0.58	0.48	0.53	0.75	0.41	0.63	0.66	0.38	0.43	0.51	0.81	0.54	0.42	0.48	0.48	0.49	0.52	1.00	0.51	0.51	0.63	0.51	0.42	0.69	0.45	0.61	0.60	0.48	1.00	0.55	0.45	1.00	0.45	1.00	0.49	0.79	0.69	0.10	0.51	0.41	0.60
6778 (STAT6)	0.48	0.50	0.54	1.00	0.41	0.48	0.51	0.48	0.60	0.48	0.41	0.52	0.59	0.49	0.49	0.56	0.54	0.42	0.52	0.56	0.52	0.60	0.47	0.54	0.81	0.54	0.54	1.00	0.56	0.51	0.38	0.58	0.49	0.68	0.48	0.49	0.51	0.52	1.00	0.65	0.80	0.45	1.00	1.00	0.60	0.52	0.69	0.10	0.54	0.45	0.66
25970 (SH2B1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	0.13	1.00	1.00	1.00
2057 (EPOR)	0.50	0.71	0.58	1.00	0.43	0.53	0.72	0.87	0.69	0.87	0.67	0.62	0.73	0.55	0.78	0.55	0.56	0.53	0.85	0.59	0.62	0.69	0.77	0.81	0.57	0.60	0.61	1.00	0.61	0.57	0.43	0.71	0.64	0.57	0.53	0.54	0.55	0.59	1.00	0.83	0.54	0.49	0.60	1.00	1.00	0.56	0.69	0.51	0.53	0.38	0.74
5894 (RAF1)	0.76	0.48	0.53	1.00	0.58	0.47	0.51	0.47	0.55	0.47	0.63	0.49	0.55	0.75	0.52	0.63	0.71	0.38	0.49	0.59	0.80	0.61	0.46	0.51	0.54	0.57	0.51	1.00	0.52	0.53	0.61	0.53	0.53	0.72	0.46	0.64	0.65	0.51	1.00	0.59	0.53	0.79	0.52	1.00	0.56	1.00	0.69	0.11	0.54	0.46	0.65
7066 (THPO)	0.84	0.69	0.70	0.69	0.69	0.69	0.69	0.69	1.00	0.69	0.69	0.69	0.69	0.69	0.69	0.70	0.70	0.70	0.69	0.70	0.69	0.69	0.69	0.69	0.69	0.69	0.70	0.69	0.69	0.70	0.70	0.69	0.69	0.69	0.84	0.69	0.70	0.69	0.69	0.69	0.69	0.69	0.69	0.69	0.69	0.69	1.00	0.09	0.69	0.69	0.69
3460 (IFNGR2)	0.09	0.39	0.10	0.13	0.08	0.09	0.34	0.66	0.11	0.66	0.49	0.11	0.12	0.11	0.55	0.10	0.09	0.08	0.71	0.09	0.11	0.11	0.45	0.43	0.09	0.09	0.10	0.13	0.17	0.10	0.09	0.12	0.28	0.11	0.11	0.18	0.15	0.10	0.13	0.12	0.14	0.10	0.10	0.13	0.51	0.11	0.09	1.00	0.13	0.08	0.11
1027 (CDKN1B)	0.52	0.55	0.56	1.00	0.43	0.47	0.52	0.49	0.56	0.49	0.45	0.73	0.60	0.50	0.58	0.62	0.55	0.38	0.50	0.59	0.49	0.61	0.48	0.52	0.51	0.60	0.70	1.00	0.72	0.78	0.39	0.54	0.54	0.51	0.46	0.55	0.59	0.74	1.00	0.56	0.57	0.51	0.54	1.00	0.53	0.54	0.69	0.13	1.00	0.39	0.60
10419 (PRMT5)	0.46	0.35	0.43	1.00	0.37	0.39	0.40	0.33	0.42	0.33	0.34	0.35	0.40	0.38	0.34	0.47	0.48	0.28	0.35	0.45	0.39	0.42	0.37	0.38	0.52	0.40	0.39	1.00	0.40	0.37	0.33	0.38	0.35	0.45	0.36	0.40	0.44	0.36	1.00	0.40	0.50	0.41	0.45	1.00	0.38	0.46	0.69	0.08	0.39	1.00	0.47
4792 (NFKBIA)	0.56	0.66	0.63	1.00	0.52	0.61	0.66	0.64	0.73	0.64	0.54	0.69	0.76	0.64	0.65	0.63	0.61	0.53	0.69	0.68	0.69	0.76	0.56	0.68	0.65	0.67	0.67	1.00	0.67	0.65	0.46	0.74	0.64	0.64	0.56	0.59	0.59	0.68	1.00	0.81	0.60	0.60	0.66	1.00	0.74	0.65	0.69	0.11	0.60	0.47	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
JAK2	Human	Blood	-	3250 m	4 day	upregulated	1.9198	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776
JAK2	Human	Blood	-	3250 m	4 day	upregulated	1.9198	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
ESR1	2099	JAK2	3717	Unknown	10606246	TRUSST
STAT3	6774	JAK2	3717	Repression	1323141	TRUSST
STAT1	6772	JAK2	3717	Unknown	23962719	TRUSST
BRCA1	672	JAK2	3717	Activation	11327698	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT000707	hsa-miR-135a-5p	Homo sapiens	JAK2	3717	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	19666866
MIRT000707	hsa-miR-135a-5p	Homo sapiens	JAK2	3717	Homo sapiens	qRT-PCR//Western blot	Functional MTI	22310976
MIRT001749	hsa-miR-375	Homo sapiens	JAK2	3717	Homo sapiens	Western blot	Functional MTI	28186962
MIRT001749	hsa-miR-375	Homo sapiens	JAK2	3717	Homo sapiens	Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	24718681
MIRT001749	hsa-miR-375	Homo sapiens	JAK2	3717	Homo sapiens	Luciferase reporter assay	Functional MTI	28006751
MIRT001749	hsa-miR-375	Homo sapiens	JAK2	3717	Homo sapiens	Luciferase reporter assay//qRT-PCR	Functional MTI	25055044
MIRT001749	hsa-miR-375	Homo sapiens	JAK2	3717	Homo sapiens	Luciferase reporter assay//Western blot//Reporter assay;Western blot	Functional MTI	20548334
MIRT001749	hsa-miR-375	Homo sapiens	JAK2	3717	Homo sapiens	Reporter assay	Functional MTI	15806104
MIRT017973	hsa-miR-335-5p	Homo sapiens	JAK2	3717	Homo sapiens	Microarray	Functional MTI (Weak)	18185580
MIRT044858	hsa-miR-195-5p	Homo sapiens	JAK2	3717	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT051067	hsa-miR-16-5p	Homo sapiens	JAK2	3717	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT379479	hsa-miR-101-3p	Homo sapiens	JAK2	3717	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26498873
MIRT379479	hsa-miR-101-3p	Homo sapiens	JAK2	3717	Homo sapiens	Flow//qRT-PCR	Functional MTI (Weak)	27517565
MIRT623561	hsa-miR-8485	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT623561	hsa-miR-8485	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	27418678
MIRT623561	hsa-miR-8485	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22927820
MIRT623561	hsa-miR-8485	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT628089	hsa-miR-548as-3p	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22927820
MIRT628089	hsa-miR-548as-3p	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT628089	hsa-miR-548as-3p	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT678309	hsa-miR-5692a	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT678309	hsa-miR-5692a	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22927820
MIRT678308	hsa-miR-568	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT678309	hsa-miR-5692a	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT678309	hsa-miR-5692a	Homo sapiens	JAK2	3717	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	27418678
MIRT734987	hsa-miR-125b-5p	Homo sapiens	JAK2	3717	Homo sapiens	qRT-PCR//Western blot	Functional MTI	26011312
MIRT735041	hsa-miR-216a-5p	Homo sapiens	JAK2	3717	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26149212
MIRT734988	hsa-miR-125a-5p	Homo sapiens	JAK2	3717	Homo sapiens	qRT-PCR//Western blot	Functional MTI	26011312
MIRT735423	hsa-miR-204-5p	Homo sapiens	JAK2	3717	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27323056

Gene Ontology

ID	GO ID	GO Term	GO Type
3717	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	GOTERM_BP_DIRECT
3717	GO:0005515	protein binding	GOTERM_MF_DIRECT
3717	GO:0005524	ATP binding	GOTERM_MF_DIRECT
3717	GO:0033130	GTPase activating protein binding	GOTERM_MF_DIRECT
3717	GO:0005634	nucleus	GOTERM_CC_DIRECT
3717	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GOTERM_BP_DIRECT
3717	GO:0042506	tyrosine phosphorylation of Stat5 protein	GOTERM_BP_DIRECT
3717	GO:0005143	growth hormone receptor binding	GOTERM_MF_DIRECT
3717	GO:0005654	nucleoplasm	GOTERM_CC_DIRECT
3717	GO:0005901	caveola	GOTERM_CC_DIRECT
3717	GO:0016363	nuclear matrix	GOTERM_CC_DIRECT
3717	GO:0032516	positive regulation of phosphoprotein phosphatase activity	GOTERM_BP_DIRECT
3717	GO:0033194	response to hydroperoxide	GOTERM_BP_DIRECT
3717	GO:0045087	innate immune response	GOTERM_BP_DIRECT
3717	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GOTERM_BP_DIRECT
3717	GO:0005102	GTPase activator activity	GOTERM_MF_DIRECT
3717	GO:0006915	apoptotic process	GOTERM_BP_DIRECT
3717	GO:0010811	positive regulation of cell-substrate adhesion	GOTERM_BP_DIRECT
3717	GO:0018108	peptidyl-tyrosine phosphorylation	GOTERM_BP_DIRECT
3717	GO:0060399	positive regulation of growth hormone receptor signaling pathway	GOTERM_BP_DIRECT
3717	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GOTERM_BP_DIRECT
3717	GO:0002250	adaptive immune response	GOTERM_BP_DIRECT
3717	GO:0007498	mesoderm development	GOTERM_BP_DIRECT
3717	GO:0046777	protein autophosphorylation	GOTERM_BP_DIRECT
3717	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GOTERM_BP_DIRECT
3717	GO:0004713	protein serine/threonine/tyrosine kinase activity	GOTERM_MF_DIRECT
3717	GO:0031702	adrenomedullin receptor binding	GOTERM_MF_DIRECT
3717	GO:0007167	enzyme linked receptor protein signaling pathway	GOTERM_BP_DIRECT
3717	GO:0031959	mineralocorticoid receptor signaling pathway	GOTERM_BP_DIRECT
3717	GO:0032731	positive regulation of interleukin-1 beta production	GOTERM_BP_DIRECT
3717	GO:0038083	peptidyl-tyrosine autophosphorylation	GOTERM_BP_DIRECT
3717	GO:0042503	tyrosine phosphorylation of Stat3 protein	GOTERM_BP_DIRECT
3717	GO:0060396	growth hormone receptor signaling pathway	GOTERM_BP_DIRECT
3717	GO:0070671	response to interleukin-12	GOTERM_BP_DIRECT
3717	GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	GOTERM_BP_DIRECT
3717	GO:0019901	protein kinase binding	GOTERM_MF_DIRECT
3717	GO:0016020	membrane	GOTERM_CC_DIRECT
3717	GO:0030335	positive regulation of cell migration	GOTERM_BP_DIRECT
3717	GO:0035722	interleukin-12-mediated signaling pathway	GOTERM_BP_DIRECT
3717	GO:0042127	regulation of cell proliferation	GOTERM_BP_DIRECT
3717	GO:0043524	negative regulation of neuron apoptotic process	GOTERM_BP_DIRECT
3717	GO:0097191	extrinsic apoptotic signaling pathway	GOTERM_BP_DIRECT
3717	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GOTERM_BP_DIRECT
3717	GO:0004715	protein tyrosine kinase activity	GOTERM_MF_DIRECT
3717	GO:0007204	positive regulation of cytosolic calcium ion concentration	GOTERM_BP_DIRECT
3717	GO:0008285	negative regulation of cell proliferation	GOTERM_BP_DIRECT
3717	GO:0016477	cell migration	GOTERM_BP_DIRECT
3717	GO:0032760	positive regulation of tumor necrosis factor production	GOTERM_BP_DIRECT
3717	GO:0033160	positive regulation of protein import into nucleus	GOTERM_BP_DIRECT
3717	GO:0033209	tumor necrosis factor-mediated signaling pathway	GOTERM_BP_DIRECT
3717	GO:0060333	interferon-gamma-mediated signaling pathway	GOTERM_BP_DIRECT
3717	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	GOTERM_BP_DIRECT
3717	GO:0005088	guanyl-nucleotide exchange factor activity	GOTERM_MF_DIRECT
3717	GO:0016301	lipase activity	GOTERM_MF_DIRECT
3717	GO:0046872	metal ion binding	GOTERM_MF_DIRECT
3717	GO:0007186	G-protein coupled receptor signaling pathway	GOTERM_BP_DIRECT
3717	GO:0007260	tyrosine phosphorylation of STAT protein	GOTERM_BP_DIRECT
3717	GO:0007262	STAT protein import into nucleus	GOTERM_BP_DIRECT
3717	GO:0007596	blood coagulation	GOTERM_BP_DIRECT
3717	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	GOTERM_BP_DIRECT
3717	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	GOTERM_BP_DIRECT
3717	GO:0042977	activation of JAK2 kinase activity	GOTERM_BP_DIRECT
3717	GO:0042981	regulation of apoptotic process	GOTERM_BP_DIRECT
3717	GO:0043560	phosphatidylinositol 3-kinase binding	GOTERM_MF_DIRECT
3717	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GOTERM_CC_DIRECT
3717	GO:0006928	movement of cell or subcellular component	GOTERM_BP_DIRECT
3717	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	GOTERM_BP_DIRECT
3717	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GOTERM_BP_DIRECT
3717	GO:0030154	cell differentiation	GOTERM_BP_DIRECT
3717	GO:0045597	positive regulation of cell differentiation	GOTERM_BP_DIRECT
3717	GO:0050729	positive regulation of inflammatory response	GOTERM_BP_DIRECT
3717	GO:0050867	positive regulation of cell activation	GOTERM_BP_DIRECT
3717	GO:0061180	mammary gland epithelium development	GOTERM_BP_DIRECT
3717	GO:0042169	chemoattractant activity	GOTERM_MF_DIRECT
3717	GO:0007259	JAK-STAT cascade	GOTERM_BP_DIRECT
3717	GO:0043388	positive regulation of DNA binding	GOTERM_BP_DIRECT
3717	GO:0043392	negative regulation of DNA binding	GOTERM_BP_DIRECT
3717	GO:0043547	positive regulation of GTPase activity	GOTERM_BP_DIRECT
3717	GO:1904037	positive regulation of epithelial cell apoptotic process	GOTERM_BP_DIRECT
3717	GO:0006468	protein phosphorylation	GOTERM_BP_DIRECT
3717	GO:0019221	cytokine-mediated signaling pathway	GOTERM_BP_DIRECT
3717	GO:0031103	axon regeneration	GOTERM_BP_DIRECT
3717	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	GOTERM_BP_DIRECT
3717	GO:0000165	MAPK cascade	GOTERM_BP_DIRECT
3717	GO:0022408	negative regulation of cell-cell adhesion	GOTERM_BP_DIRECT
3717	GO:0030041	actin filament polymerization	GOTERM_BP_DIRECT
3717	GO:0030218	erythrocyte differentiation	GOTERM_BP_DIRECT
3717	GO:0035556	intracellular signal transduction	GOTERM_BP_DIRECT
3717	GO:0042508	tyrosine phosphorylation of Stat1 protein	GOTERM_BP_DIRECT
3717	GO:0020037	interleukin-1 binding	GOTERM_MF_DIRECT
3717	GO:0035401	enhancer binding	GOTERM_MF_DIRECT
3717	GO:0042393	sphingosine-1-phosphate phosphatase activity	GOTERM_MF_DIRECT
3717	GO:0043548	protein serine/threonine kinase activator activity	GOTERM_MF_DIRECT
3717	GO:0051428	alpha-actinin binding	GOTERM_MF_DIRECT
3717	GO:0032024	positive regulation of insulin secretion	GOTERM_BP_DIRECT
3717	GO:0034612	response to tumor necrosis factor	GOTERM_BP_DIRECT
3717	GO:0045429	positive regulation of nitric oxide biosynthetic process	GOTERM_BP_DIRECT
3717	GO:0050727	regulation of inflammatory response	GOTERM_BP_DIRECT
3717	GO:0004672	prostaglandin-D synthase activity	GOTERM_MF_DIRECT
3717	GO:0008022	microtubule binding	GOTERM_MF_DIRECT
3717	GO:0005829	cytosol	GOTERM_CC_DIRECT
3717	GO:0045121	membrane raft	GOTERM_CC_DIRECT
3717	GO:0000186	activation of MAPKK activity	GOTERM_BP_DIRECT
3717	GO:0007165	signal transduction	GOTERM_BP_DIRECT
3717	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GOTERM_BP_DIRECT
3717	GO:0032496	response to lipopolysaccharide	GOTERM_BP_DIRECT
3717	GO:0035409	histone H3-Y41 phosphorylation	GOTERM_BP_DIRECT
3717	GO:0045822	negative regulation of heart contraction	GOTERM_BP_DIRECT
3717	GO:0046677	response to antibiotic	GOTERM_BP_DIRECT
3717	GO:0048008	platelet-derived growth factor receptor signaling pathway	GOTERM_BP_DIRECT
3717	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
3717	GO:0005856	cytoskeleton	GOTERM_CC_DIRECT
3717	GO:0005131	cytokine receptor binding	GOTERM_MF_DIRECT
3717	GO:0031904	endosome lumen	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
3717	hsa04062	Chemokine signaling pathway
3717	hsa04151	PI3K-Akt signaling pathway
3717	hsa04550	Signaling pathways regulating pluripotency of stem cells
3717	hsa04630	Jak-STAT signaling pathway
3717	hsa04725	Cholinergic synapse
3717	hsa04917	Prolactin signaling pathway
3717	hsa04920	Adipocytokine signaling pathway
3717	hsa05145	Toxoplasmosis
3717	hsa05168	Herpes simplex infection
3717	hsa05152	Tuberculosis
3717	hsa05140	Leishmaniasis
3717	hsa05162	Measles
3717	hsa05164	Influenza A

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
JAK2	3717	Diffuse Large B-Cell Lymphoma	C0079744	Neoplastic Process	0.34	0.43	0.69	disease
JAK2	3717	Precursor Cell Lymphoblastic Leukemia Lymphoma	C1961102	Neoplastic Process	0.4	0.43	0.69	disease
JAK2	3717	Childhood Diffuse Large B-Cell Lymphoma	C1332967	Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	Myeloid Leukemia, Chronic	C0023473	Neoplastic Process	0.5	0.43	0.69	disease
JAK2	3717	Adult Diffuse Large B-Cell Lymphoma	C1332201	Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	Hematologic Neoplasms	C0376545	Neoplastic Process	0.4	0.43	0.69	group
JAK2	3717	Primary Myelofibrosis	C0001815	Neoplastic Process	1	0.43	0.69	disease
JAK2	3717	Leukemia, Myelocytic, Acute	C0023467	Neoplastic Process	0.8	0.43	0.69	disease
JAK2	3717	Hepatoma, Novikoff	C0019208	Experimental Model of Disease; Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	Experimental Hepatoma	C0086404	Experimental Model of Disease; Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	Tumoral calcinosis	C0263628	Disease or Syndrome	0.3	0.43	0.69	disease
JAK2	3717	Deep Vein Thrombosis	C0149871	Disease or Syndrome	0.3	0.43	0.69	disease
JAK2	3717	Thrombocytosis	C0836924	Disease or Syndrome	0.5	0.43	0.69	disease
JAK2	3717	Nonalcoholic Steatohepatitis	C3241937	Disease or Syndrome	0.3	0.43	0.69	disease
JAK2	3717	Thrombocytosis, Autosomal Dominant	C3489628	Disease or Syndrome	0.3	0.43	0.69	disease
JAK2	3717	Ulcerative Colitis	C0009324	Disease or Syndrome	0.38	0.43	0.69	disease
JAK2	3717	Pregnancy Complications	C0032962	Pathologic Function	0.31	0.43	0.69	group
JAK2	3717	Prostatic Neoplasms	C0033578	Neoplastic Process	0.3	0.43	0.69	group
JAK2	3717	Non-alcoholic Fatty Liver Disease	C0400966	Disease or Syndrome	0.3	0.43	0.69	disease
JAK2	3717	Mesenteric Vascular Occlusion	C0025472	Disease or Syndrome	0.3	0.43	0.69	disease
JAK2	3717	Uterine Cervical Neoplasm	C0007873	Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.43	0.69	disease
JAK2	3717	Heart valve disease	C0018824	Disease or Syndrome	0.3	0.43	0.69	group
JAK2	3717	Acute Myeloid Leukemia, M1	C0026998	Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	Familial erythrocytosis	C0152264	Disease or Syndrome	0.33	0.43	0.69	disease
JAK2	3717	Polycythemia	C0032461	Disease or Syndrome	0.4	0.43	0.69	disease
JAK2	3717	Thromboembolism	C0040038	Pathologic Function	0.41	0.43	0.69	phenotype
JAK2	3717	Venous Thrombosis	C0042487	Pathologic Function	0.46	0.43	0.69	phenotype
JAK2	3717	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.36	0.43	0.69	disease
JAK2	3717	Microcalcification	C0521174	Pathologic Function	0.3	0.43	0.69	phenotype
JAK2	3717	Abortion, Tubal	C0000822	Pathologic Function	0.3	0.43	0.69	disease
JAK2	3717	leukemia	C0023418	Neoplastic Process	0.4	0.43	0.69	disease
JAK2	3717	cervical cancer	C4048328	Neoplastic Process	0.31	0.43	0.69	disease
JAK2	3717	Myeloproliferative disease	C0027022	Neoplastic Process	0.5	0.43	0.69	group
JAK2	3717	Inflammation	C0021368	Pathologic Function	0.3	0.43	0.69	phenotype
JAK2	3717	Spontaneous abortion	C0000786	Pathologic Function	0.3	0.43	0.69	phenotype
JAK2	3717	Calcinosis	C0006663	Pathologic Function	0.3	0.43	0.69	phenotype
JAK2	3717	Hepatoma, Morris	C0019207	Experimental Model of Disease; Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	Liver Neoplasms, Experimental	C0023904	Experimental Model of Disease; Neoplastic Process	0.3	0.43	0.69	group
JAK2	3717	Myocardial Ischemia	C0151744	Disease or Syndrome	0.31	0.43	0.69	disease
JAK2	3717	Acute Myeloid Leukemia (AML-M2)	C1879321	Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	Erythrocytosis	C1527405	Finding	0.3	0.43	0.69	phenotype
JAK2	3717	Thrombocythemia, Essential	C0040028	Disease or Syndrome	0.8	0.43	0.69	disease
JAK2	3717	Budd-Chiari Syndrome	C0856761	Disease or Syndrome	0.7	0.43	0.69	disease
JAK2	3717	Hepatic Vein Thrombosis	C0019154	Disease or Syndrome	0.58	0.43	0.69	disease
JAK2	3717	Polycythemia Vera	C0032463	Neoplastic Process	1	0.43	0.69	disease
JAK2	3717	Cytopenia	C0010828	Pathologic Function	0.3	0.43	0.69	phenotype
JAK2	3717	Congenital anemia	C0158995	Disease or Syndrome	0.3	0.43	0.69	disease
JAK2	3717	Familial thrombocytosis	C4303761	Disease or Syndrome	0.3	0.43	0.69	disease
JAK2	3717	Myelofibrosis	C0026987	Neoplastic Process	0.7	0.43	0.69	disease
JAK2	3717	Ovarian Serous Adenocarcinoma	C1335177	Neoplastic Process	0.3	0.43	0.69	disease
JAK2	3717	LEUKEMIA, ACUTE MYELOID, SUSCEPTIBILITY TO	C3275959	Finding	0.3	0.43	0.69	phenotype
JAK2	3717	THROMBOCYTHEMIA 3	C3281125	Disease or Syndrome	0.4	0.43	0.69	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
JAK2	3717	A-1155463	None	None	None
JAK2	3717	AC430	None	None	inhibitor
JAK2	3717	AC-430	AC-430	CHEMBL3545241	inhibitor
JAK2	3717	AC430	AC-430	CHEMBL3545241	None
JAK2	3717	AT9283	AT-9283	CHEMBL495727	inhibitor
JAK2	3717	AT9283	AT-9283	CHEMBL495727	inhibitor
JAK2	3717	AT-9283	AT-9283	CHEMBL495727	inhibitor
JAK2	3717	AT-9283	AT-9283	CHEMBL495727	inhibitor
JAK2	3717	AUY922	NVP-AUY922	CHEMBL252164	None
JAK2	3717	AZ960	None	None	None
JAK2	3717	AZD1480	AZD-1480	CHEMBL1231124	inhibitor
JAK2	3717	AZD1208	AZD-1208	CHEMBL3545423	None
JAK2	3717	AZD1480	AZD-1480	CHEMBL1231124	inhibitor
JAK2	3717	AZ960	None	None	inhibitor
JAK2	3717	AZD1480	AZD-1480	CHEMBL1231124	None
JAK2	3717	AZD-1480	AZD-1480	CHEMBL1231124	inhibitor
JAK2	3717	BARICITINIB	BARICITINIB	CHEMBL2105759	inhibitor
JAK2	3717	BARICITINIB	BARICITINIB	CHEMBL2105759	inhibitor
JAK2	3717	BEZ235	DACTOLISIB	CHEMBL1879463	None
JAK2	3717	BMS-911543	BMS-911543	CHEMBL3545215	inhibitor
JAK2	3717	BMS-911543	BMS-911543	CHEMBL3545215	inhibitor
JAK2	3717	CERDULATINIB	Cerdulatinib	CHEMBL3545284	inhibitor
JAK2	3717	CEP-33779	CHEMBL2062804	CHEMBL2062804	inhibitor
JAK2	3717	CHZ868	None	None	None
JAK2	3717	COMPOUND 19A [PMID: 24359159]	CHEMBL3116050	CHEMBL3116050	inhibitor
JAK2	3717	COMPOUND 1D [PMID: 21493067]	None	None	inhibitor
JAK2	3717	CT-1578	CT-1578	CHEMBL3544962	inhibitor
JAK2	3717	DECERNOTINIB	DECERNOTINIB	CHEMBL3039513	inhibitor
JAK2	3717	ENMD-2076	ENMD-2076	CHEMBL482968	None
JAK2	3717	FEDRATINIB	FEDRATINIB	CHEMBL1287853	inhibitor
JAK2	3717	FEDRATINIB	FEDRATINIB	CHEMBL1287853	inhibitor
JAK2	3717	FILGOTINIB	FILGOTINIB	CHEMBL3301607	inhibitor
JAK2	3717	GANDOTINIB	GANDOTINIB	CHEMBL2107823	inhibitor
JAK2	3717	GANDOTINIB	GANDOTINIB	CHEMBL2107823	inhibitor
JAK2	3717	GDC-0941	PICTILISIB	CHEMBL521851	None
JAK2	3717	GLPG0634	FILGOTINIB	CHEMBL3301607	None
JAK2	3717	Go 6976	GO-6976	CHEMBL302449	None
JAK2	3717	GSAO	None	None	inhibitor
JAK2	3717	HG-10-102-01	None	None	inhibitor
JAK2	3717	Imatinib	IMATINIB	CHEMBL941	None
JAK2	3717	INCB18424	RUXOLITINIB PHOSPHATE	CHEMBL1795071	inhibitor
JAK2	3717	INCB28050	PIBOSEROD	CHEMBL356359	inhibitor
JAK2	3717	INCB18424	RUXOLITINIB	CHEMBL1789941	None
JAK2	3717	INCB018424	RUXOLITINIB PHOSPHATE	CHEMBL1795071	inhibitor
JAK2	3717	ITF2357	CHEMBL1213492	CHEMBL1213492	inhibitor
JAK2	3717	INCB018424	RUXOLITINIB PHOSPHATE	CHEMBL1795071	inhibitor
JAK2	3717	ITACITINIB	ITACITINIB	CHEMBL3622820	inhibitor
JAK2	3717	JAK3 INHIBITOR II	None	None	inhibitor
JAK2	3717	JAK INHIBITOR I	CHEMBL21156	CHEMBL21156	inhibitor
JAK2	3717	LESTAURTINIB	LESTAURTINIB	CHEMBL603469	inhibitor
JAK2	3717	JTE-052	PAROXETINE	CHEMBL490	inhibitor
JAK2	3717	LESTAURTINIB	LESTAURTINIB	CHEMBL603469	None
JAK2	3717	Lestaurtinib	LESTAURTINIB	CHEMBL603469	None
JAK2	3717	LY2784544	GANDOTINIB	CHEMBL2107823	inhibitor
JAK2	3717	LY3009104	BARICITINIB	CHEMBL2105759	None
JAK2	3717	LS-104	LS-104	CHEMBL3544997	inhibitor
JAK2	3717	MOMELOTINIB	MOMELOTINIB	CHEMBL1078178	inhibitor
JAK2	3717	MOMELOTINIB	MOMELOTINIB	CHEMBL1078178	inhibitor
JAK2	3717	Momelotinib	MOMELOTINIB	CHEMBL1078178	None
JAK2	3717	NS-018	NS-018	CHEMBL3545217	inhibitor
JAK2	3717	NS-018	NS-018	CHEMBL3545217	inhibitor
JAK2	3717	NVP-BVB808	None	None	None
JAK2	3717	NVP-BSK805	None	None	None
JAK2	3717	paclitaxel	PACLITAXEL	CHEMBL428647	None
JAK2	3717	PACRITINIB	PACRITINIB	CHEMBL2035187	inhibitor
JAK2	3717	PACRITINIB	PACRITINIB	CHEMBL2035187	inhibitor
JAK2	3717	PEGYLATED IFN-ALPHA-2A	None	None	None
JAK2	3717	PEMBROLIZUMAB	PEMBROLIZUMAB	CHEMBL3137343	None
JAK2	3717	PEFICITINIB	PEFICITINIB	CHEMBL3137308	inhibitor
JAK2	3717	Pembrolizumab	PEMBROLIZUMAB	CHEMBL3137343	None
JAK2	3717	Pyridone 6	CHEMBL21156	CHEMBL21156	None
JAK2	3717	RGB-286638	RGB-286638	CHEMBL3545083	inhibitor
JAK2	3717	Ruxolitinib	RUXOLITINIB	CHEMBL1789941	None
JAK2	3717	Ruxolitinib	RUXOLITINIB	CHEMBL1789941	None
JAK2	3717	Ruxolitinib	RUXOLITINIB	CHEMBL1789941	None
JAK2	3717	RUXOLITINIB	RUXOLITINIB	CHEMBL1789941	inhibitor
JAK2	3717	RUXOLITINIB	RUXOLITINIB	CHEMBL1789941	inhibitor
JAK2	3717	RUXOLITINIB	RUXOLITINIB	CHEMBL1789941	None
JAK2	3717	RUXOLITINIB	RUXOLITINIB	CHEMBL1789941	inhibitor
JAK2	3717	RP6530	RP-6530	CHEMBL3545141	None
JAK2	3717	RUXOLITINIB PHOSPHATE	RUXOLITINIB PHOSPHATE	CHEMBL1795071	inhibitor
JAK2	3717	SAR302503	FEDRATINIB	CHEMBL1287853	None
JAK2	3717	SAR302503	FEDRATINIB	CHEMBL1287853	inhibitor
JAK2	3717	SGI-1776	SGI-1776	CHEMBL1952329	None
JAK2	3717	SHP099	None	None	None
JAK2	3717	SB1518	PACRITINIB	CHEMBL2035187	None
JAK2	3717	TG02	TG-02	CHEMBL1944698	inhibitor
JAK2	3717	TG101348	FEDRATINIB	CHEMBL1287853	None
JAK2	3717	TG101348	FEDRATINIB	CHEMBL1287853	None
JAK2	3717	TG-02	TG-02	CHEMBL1944698	inhibitor
JAK2	3717	TG02, SB1317	None	None	None
JAK2	3717	TG101348	FEDRATINIB	CHEMBL1287853	inhibitor
JAK2	3717	TGX-221	None	None	None
JAK2	3717	TOFACITINIB CITRATE	TOFACITINIB CITRATE	CHEMBL2103743	inhibitor
JAK2	3717	XL019	XL-019	CHEMBL3545328	inhibitor
JAK2	3717	XL019	XL-019	CHEMBL3545328	inhibitor
JAK2	3717	ZSTK474	ZSTK-474	CHEMBL586701	None
JAK2	3717	XL-019	XL-019	CHEMBL3545328	inhibitor
JAK2	3717	XL019	XL-019	CHEMBL3545328	None