ALTITUDEOMICSDB

Erythropoietin

AltitudeomicsDB

Protein Official symbol	EPO
Aliases	EPO
Chromosomal Location	7
Length	193
Uniprot ID	P01588
EC number	None
Protein family Information(Pfam)	PF00758;
PDB id	1BUY;1CN4;1EER;
InterPro ID	IPR009079;IPR019767;IPR001323;IPR003013;
dbSNP	rs62483572 rs137953994 rs11976235 rs149431976 rs1358275550

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
CREB1	CREBBP	0.999
SHC1	GRB2	0.999
SOS1	GRB2	0.999
KIT	KITLG	0.999
JAK2	STAT5A	0.999
MAPK8	JUN	0.999
EPO	EPOR	0.999
GRB2	CBL	0.999
JAK2	STAT5B	0.999
HIF1A	EP300	0.998
HIF1A	CREBBP	0.998
JAK2	STAT1	0.998
HIF1A	ARNT	0.998
CREB1	EP300	0.997
ARNT	EPAS1	0.997
GRB2	GAB1	0.996
VEGFA	HIF1A	0.996
STAT1	CREBBP	0.995
CRKL	CBL	0.995
JUN	MAPK14	0.995
JAK2	EPOR	0.995
JAK2	SOCS3	0.994
SHC1	CBL	0.994
JUN	COPS5	0.994
CREB1	JUN	0.993
EP300	CREBBP	0.99
STAT5A	EPOR	0.989
SHC1	SOS1	0.989
JAK2	EPO	0.988
EPAS1	EP300	0.988
STAT5A	PRL	0.986
GRB2	JAK2	0.986
STAT1	SOCS3	0.986
CREB1	MAPK14	0.985
LYN	SHC1	0.985
LYN	PTPN6	0.984
HIF1A	EPO	0.984
EPO	KITLG	0.984
IL3	STAT5B	0.984
PTPN6	JAK2	0.983
VEGFA	JUN	0.983
STAT5A	IL3	0.983
PRL	STAT5B	0.983
STAT1	MAPK14	0.982
STAT5B	EPOR	0.982
JAK2	IRS2	0.982
EPO	CSF3	0.981
ARNT	EP300	0.98
STAT1	KIT	0.98
JAK2	PRL	0.98
VEGFA	EPAS1	0.98
JUN	EP300	0.979
JAK2	SH2B3	0.979
LYN	CBL	0.979
EPAS1	CREBBP	0.979
STAT1	EP300	0.978
CRKL	GAB1	0.978
PTPN6	STAT5B	0.978
SOS1	GAB1	0.977
VEGFA	ARNT	0.977
LYN	EPOR	0.976
LYN	STAT5A	0.976
STAT5A	EPO	0.976
SHC1	IRS2	0.976
SHC1	JAK2	0.976
LYN	STAT5B	0.975
STAT1	STAT5A	0.975
SHC1	MAPK8	0.975
SHC1	GAB1	0.975
JUN	CREBBP	0.974
STAT5B	EPO	0.974
STAT5A	SOCS3	0.973
VEGFA	EP300	0.973
SOCS3	STAT5B	0.973
CBL	PLCG1	0.972
LYN	CRKL	0.972
STAT5A	KIT	0.972
PTPN6	STAT5A	0.971
PLCG1	EPOR	0.971
KIT	EPOR	0.97
STAT5B	KIT	0.97
HIF1A	COPS5	0.97
KITLG	EPOR	0.97
STAT5A	CREBBP	0.97
HIF1A	JUN	0.97
VEGFA	CREB1	0.97
STAT5A	EP300	0.969
KIT	EPO	0.969
EPAS1	EPO	0.969
HIF3A	ARNT	0.968
MAPK8	EP300	0.968
STAT5B	EP300	0.968
LYN	PLCG1	0.968
GRB2	KIT	0.967
BTK	CBL	0.966
EPO	THPO	0.966
JAK2	IL3	0.966
SOS1	PLCG1	0.966
GRB2	EPOR	0.965
JAK2	THPO	0.965
SOS1	CBL	0.965
SHC1	MAPK14	0.964
STAT5B	CREBBP	0.964
SOCS3	EPOR	0.963
SOCS3	EPO	0.963
GRB2	PLCG1	0.963
HIF3A	EP300	0.962
GRB2	VAV2	0.961
SHC1	PTPN6	0.961
KIT	CBL	0.961
BTK	PTPN6	0.961
SH2B3	KIT	0.96
JAK2	KIT	0.96
EP300	NFKB1	0.96
STAT5B	THPO	0.96
ARNT	CREBBP	0.96
HIF3A	CREBBP	0.959
GRB2	IRS2	0.959
TEC	PLCG1	0.959
GAB1	PLCG1	0.958
IRS2	SOCS3	0.958
STAT5A	THPO	0.957
MAPK8	CRKL	0.957
SOS1	VAV2	0.957
VEGFA	CREBBP	0.956
JAK2	PLCG1	0.956
CSF3	THPO	0.956
SHC1	EPOR	0.956
ARNT	EPO	0.956
BTK	PLCG1	0.955
PTPN6	EPOR	0.954
PTPN6	KIT	0.953
LYN	KIT	0.953
VEGFA	KIT	0.953
SH2B3	EPOR	0.953
JAK2	CBL	0.953
EP300	MAPK14	0.95
BTK	LYN	0.95
LYN	JAK2	0.95
JUN	ARNT	0.95
GRB2	TEC	0.95
PTPN6	CBL	0.949
STAT5A	STAT5B	0.949
JAK2	CRKL	0.948
BTK	SHC1	0.948
MAPK14	NFKB1	0.948
VEGFA	GRB2	0.948
SHC1	KIT	0.947
VEGFA	SHC1	0.947
JAK2	NFKB1	0.946
SOS1	RAP1A	0.946
BTK	EPO	0.945
LYN	VAV2	0.945
BTK	GRB2	0.945
JAK2	KITLG	0.945
GRB2	CRKL	0.945
CRKL	EPOR	0.944
LYN	STAT1	0.944
GRB2	SH2B3	0.944
LYN	JUN	0.944
IRS2	EPOR	0.944
HIF1A	CREB1	0.943
MAPK8	MAPK14	0.943
MAPK8	IRS2	0.943
EP300	EPO	0.943
STAT1	STAT5B	0.943
VAV2	RAP1A	0.943
CREB1	GRB2	0.942
TEC	VAV2	0.942
SHC1	CREB1	0.942
GRB2	IL3	0.942
SHC1	IL3	0.942
STAT1	PRL	0.941
LYN	MAPK8	0.941
LYN	TEC	0.941
GAB1	EPOR	0.941
STAT1	EPO	0.941
SH2B3	EPO	0.94
HIF3A	EPAS1	0.94
TEC	KIT	0.94
BTK	JUN	0.94
LYN	KITLG	0.94
LYN	GRB2	0.939
CBL	EPOR	0.939
HIF1A	HIF3A	0.939
SOS1	EPOR	0.938
MAPK8	EPO	0.937
GRB2	KITLG	0.937
JAK2	TEC	0.937
MAPK8	NFKB1	0.935
VEGFA	PLCG1	0.935
JUN	EPO	0.935
STAT1	EPOR	0.935
BTK	TEC	0.934
CREB1	ARNT	0.934
MAPK8	KITLG	0.933
CREBBP	MAPK14	0.933
SHC1	THPO	0.932
CREBBP	NFKB1	0.932
RAP1A	CRKL	0.932
SOS1	JAK2	0.932
GRB2	EPO	0.932
COPS5	EP300	0.932
SH2B3	KITLG	0.93
LYN	MAPK14	0.93
CREB1	EPO	0.93
PTPN6	CRKL	0.93
LYN	EPO	0.929
PTPN6	SOCS3	0.929
SHC1	KITLG	0.929
IRS2	PRL	0.929
STAT1	THPO	0.929
VEGFA	HIF3A	0.929
VEGFA	SOS1	0.928
CREBBP	EPO	0.928
LYN	SOS1	0.928
BTK	MAPK8	0.927
SH2B3	SOCS3	0.927
HIF3A	EPO	0.926
PTPN6	NFKB1	0.926
SHC1	EPO	0.926
EPO	MAPK14	0.925
LYN	NFKB1	0.924
STAT5A	PLCG1	0.924
BTK	VAV2	0.924
PTPN6	IL3	0.923
SOS1	KIT	0.922
MAPK8	KIT	0.922
MAPK8	GAB1	0.922
CREB1	PLCG1	0.922
MAPK8	EPOR	0.921
BTK	SOS1	0.921
JAK2	RAP1A	0.921
SOS1	IL3	0.921
VEGFA	CBL	0.921
STAT1	PLCG1	0.921
CBL	EPO	0.921
IL3	KITLG	0.92
SOS1	IRS2	0.92
JAK2	GAB1	0.92
CRKL	EPO	0.92
COPS5	EPO	0.919
BTK	JAK2	0.919
JAK2	VAV2	0.919
VEGFA	PTPN6	0.919
SOCS3	CBL	0.919
NFKB1	EPOR	0.918
SOS1	CREB1	0.918
VEGFA	COPS5	0.918
GRB2	THPO	0.918
PTPN6	EPO	0.918
EPO	PLCG1	0.918
ARNT	COPS5	0.918
IRS2	EPO	0.918
CRKL	SOCS3	0.918
VEGFA	EPO	0.918
EPO	NFKB1	0.918
MAPK14	EPOR	0.916
HIF1A	EPAS1	0.916
GRB2	COPS5	0.915
VEGFA	GAB1	0.915
PLCG1	THPO	0.915
IL3	EPO	0.915
VAV2	PLCG1	0.914
RAP1A	GAB1	0.914
BTK	EPOR	0.914
KIT	GAB1	0.913
PTPN6	KITLG	0.913
SOS1	TEC	0.912
SHC1	RAP1A	0.909
CREB1	COPS5	0.908
PRL	EPO	0.908
SOS1	KITLG	0.908
GAB1	EPO	0.907
RAP1A	CBL	0.906
SOS1	EPO	0.905
GAB1	KITLG	0.905
TEC	EPOR	0.904
TEC	KITLG	0.903
RAP1A	EPO	0.902
COPS5	SOCS3	0.902
HAMP	EPO	0.902
RAP1A	EPOR	0.901
TEC	EPO	0.9
SOS1	THPO	0.9
VAV2	EPOR	0.9
COPS5	PLCG1	0.9
VAV2	EPO	0.9

Gene Ontology Semantic Similarity

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#	1385 (CREB1)	6464 (SHC1)	6654 (SOS1)	3815 (KIT)	3717 (JAK2)	5599 (MAPK8)	2056 (EPO)	2885 (GRB2)	3091 (HIF1A)	405 (ARNT)	7422 (VEGFA)	6772 (STAT1)	1399 (CRKL)	3725 (JUN)	2033 (EP300)	6776 (STAT5A)	2034 (EPAS1)	4067 (LYN)	3562 (IL3)	5777 (PTPN6)	5617 (PRL)	6777 (STAT5B)	9021 (SOCS3)	867 (CBL)	5335 (PLCG1)	4254 (KITLG)	64344 (HIF3A)	695 (BTK)	10019 (SH2B3)	7006 (TEC)	2549 (GAB1)	8660 (IRS2)	1440 (CSF3)	1432 (MAPK14)	7410 (VAV2)	1387 (CREBBP)	5906 (RAP1A)	10987 (COPS5)	4790 (NFKB1)	2057 (EPOR)	7066 (THPO)
1385 (CREB1)	1.00	0.46	0.37	0.39	0.47	0.42	0.43	0.51	0.80	0.78	0.53	0.80	0.53	0.89	0.54	0.67	0.74	0.41	0.24	0.39	0.45	0.66	0.39	0.60	0.41	0.39	1.00	0.41	0.42	0.40	0.40	0.41	0.43	0.45	0.41	0.72	0.41	0.44	0.85	0.45	0.37
6464 (SHC1)	0.46	1.00	0.67	0.57	0.63	0.52	0.59	0.77	0.59	0.52	0.63	0.54	0.65	0.48	0.44	0.51	0.57	0.59	0.52	0.58	0.61	0.53	0.55	0.65	0.62	0.64	0.21	0.56	0.69	0.63	0.54	0.67	0.59	0.54	0.72	0.48	0.62	0.47	0.49	0.58	0.62
6654 (SOS1)	0.37	0.67	1.00	0.60	0.61	0.48	0.54	0.65	0.53	0.44	0.56	0.49	0.53	0.49	0.38	0.38	0.49	0.43	0.64	0.38	0.51	0.43	0.48	0.46	0.41	0.76	0.21	0.39	0.45	0.41	0.40	0.68	0.47	0.45	0.86	0.41	0.68	0.34	0.41	0.47	0.43
3815 (KIT)	0.39	0.57	0.60	1.00	0.76	0.65	0.47	0.71	0.52	0.48	0.58	0.51	0.52	0.45	0.43	0.62	0.48	0.69	0.65	0.49	0.49	0.63	0.43	0.50	0.42	0.77	0.21	0.66	0.46	0.64	0.66	0.75	0.44	0.64	0.58	0.44	0.53	0.37	0.42	0.63	0.41
3717 (JAK2)	0.47	0.63	0.61	0.76	1.00	0.70	0.55	0.75	0.59	0.52	0.63	0.56	0.58	0.50	0.50	0.69	0.55	0.77	0.68	0.51	0.57	0.68	0.50	0.58	0.53	0.70	0.21	0.74	0.53	0.71	0.63	0.70	0.54	0.71	0.60	0.50	0.56	0.46	0.49	0.54	0.51
5599 (MAPK8)	0.42	0.52	0.48	0.65	0.70	1.00	0.51	0.63	0.56	0.45	0.55	0.52	0.52	0.47	0.47	0.63	0.50	0.71	0.54	0.43	0.51	0.62	0.49	0.55	0.45	0.63	0.21	0.64	0.47	0.64	0.63	0.64	0.52	0.83	0.50	0.47	0.46	0.39	0.42	0.48	0.42
2056 (EPO)	0.43	0.59	0.54	0.47	0.55	0.51	1.00	0.57	0.59	0.51	0.66	0.54	0.65	0.48	0.42	0.50	0.59	0.54	0.43	0.48	0.71	0.53	0.68	0.55	0.53	0.55	0.21	0.49	0.63	0.56	0.53	0.54	0.72	0.53	0.58	0.47	0.56	0.43	0.47	0.62	0.67
2885 (GRB2)	0.51	0.77	0.65	0.71	0.75	0.63	0.57	1.00	0.62	0.57	0.62	0.58	0.75	0.57	0.51	0.59	0.61	0.66	0.52	0.58	0.59	0.59	0.55	0.64	0.62	0.76	0.21	0.62	0.58	0.61	0.77	0.78	0.54	0.64	0.69	0.53	0.61	0.53	0.54	0.59	0.53
3091 (HIF1A)	0.80	0.59	0.53	0.52	0.59	0.56	0.59	0.62	1.00	0.86	0.62	0.83	0.63	0.82	0.56	0.76	0.89	0.55	0.32	0.57	0.61	0.77	0.56	0.71	0.59	0.56	1.00	0.54	0.60	0.57	0.55	0.55	0.58	0.61	0.57	0.70	0.56	0.53	0.80	0.59	0.52
405 (ARNT)	0.78	0.52	0.44	0.48	0.52	0.45	0.51	0.57	0.86	1.00	0.61	0.79	0.62	0.83	0.52	0.70	0.89	0.48	0.28	0.45	0.54	0.70	0.47	0.63	0.47	0.47	1.00	0.47	0.51	0.48	0.47	0.47	0.47	0.50	0.49	0.68	0.48	0.46	0.86	0.52	0.46
7422 (VEGFA)	0.53	0.63	0.56	0.58	0.63	0.55	0.66	0.62	0.62	0.61	1.00	0.60	0.64	0.56	0.48	0.57	0.63	0.61	0.48	0.55	0.66	0.59	0.58	0.59	0.57	0.58	0.28	0.59	0.61	0.61	0.57	0.57	0.69	0.57	0.59	0.53	0.59	0.53	0.57	0.64	0.65
6772 (STAT1)	0.80	0.54	0.49	0.51	0.56	0.52	0.54	0.58	0.83	0.79	0.60	1.00	0.64	0.81	0.59	0.69	0.78	0.51	0.31	0.50	0.56	0.73	0.51	0.66	0.51	0.51	1.00	0.52	0.54	0.52	0.51	0.51	0.53	0.55	0.52	0.70	0.53	0.49	0.80	0.56	0.47
1399 (CRKL)	0.53	0.65	0.53	0.52	0.58	0.52	0.65	0.75	0.63	0.62	0.64	0.64	1.00	0.59	0.49	0.56	0.71	0.56	0.33	0.60	0.70	0.57	0.59	0.63	0.58	0.60	0.21	0.58	0.70	0.61	0.67	0.57	0.60	0.57	0.69	0.54	0.60	0.57	0.58	0.71	0.60
3725 (JUN)	0.89	0.48	0.49	0.45	0.50	0.47	0.48	0.57	0.82	0.83	0.56	0.81	0.59	1.00	0.60	0.62	0.78	0.44	0.26	0.43	0.47	0.63	0.45	0.58	0.44	0.44	1.00	0.45	0.46	0.44	0.43	0.45	0.43	0.48	0.46	0.74	0.45	0.52	0.84	0.48	0.38
2033 (EP300)	0.54	0.44	0.38	0.43	0.50	0.47	0.42	0.51	0.56	0.52	0.48	0.59	0.49	0.60	1.00	0.42	0.55	0.48	0.27	0.40	0.43	0.50	0.39	0.48	0.41	0.42	0.21	0.43	0.41	0.43	0.43	0.44	0.38	0.46	0.41	0.79	0.42	0.47	0.52	0.42	0.37
6776 (STAT5A)	0.67	0.51	0.38	0.62	0.69	0.63	0.50	0.59	0.76	0.70	0.57	0.69	0.56	0.62	0.42	1.00	0.71	0.70	0.52	0.40	0.56	0.89	0.41	0.69	0.44	0.54	1.00	0.66	0.50	0.66	0.59	0.57	0.50	0.65	0.46	0.58	0.45	0.35	0.67	0.51	0.47
2034 (EPAS1)	0.74	0.57	0.49	0.48	0.55	0.50	0.59	0.61	0.89	0.89	0.63	0.78	0.71	0.78	0.55	0.71	1.00	0.52	0.31	0.50	0.64	0.70	0.54	0.63	0.54	0.54	1.00	0.52	0.61	0.56	0.54	0.53	0.58	0.56	0.56	0.67	0.55	0.51	0.81	0.61	0.54
4067 (LYN)	0.41	0.59	0.43	0.69	0.77	0.71	0.54	0.66	0.55	0.48	0.61	0.51	0.56	0.44	0.48	0.70	0.52	1.00	0.60	0.59	0.58	0.68	0.46	0.61	0.48	0.62	0.21	0.73	0.52	0.75	0.65	0.64	0.54	0.69	0.48	0.49	0.48	0.43	0.45	0.52	0.55
3562 (IL3)	0.24	0.52	0.64	0.65	0.68	0.54	0.43	0.52	0.32	0.28	0.48	0.31	0.33	0.26	0.27	0.52	0.31	0.60	1.00	0.25	0.46	0.47	0.33	0.37	0.31	0.70	0.17	0.54	0.35	0.55	0.47	0.63	0.48	0.49	0.57	0.28	0.48	0.24	0.25	0.32	0.42
5777 (PTPN6)	0.39	0.58	0.38	0.49	0.51	0.43	0.48	0.58	0.57	0.45	0.55	0.50	0.60	0.43	0.40	0.40	0.50	0.59	0.25	1.00	0.52	0.45	0.41	0.50	0.59	0.42	0.21	0.41	0.50	0.44	0.42	0.44	0.49	0.50	0.53	0.42	0.44	0.40	0.42	0.57	0.43
5617 (PRL)	0.45	0.61	0.51	0.49	0.57	0.51	0.71	0.59	0.61	0.54	0.66	0.56	0.70	0.47	0.43	0.56	0.64	0.58	0.46	0.52	1.00	0.57	0.60	0.59	0.59	0.60	0.21	0.53	0.74	0.63	0.58	0.57	0.72	0.57	0.62	0.48	0.61	0.46	0.50	0.71	0.79
6777 (STAT5B)	0.66	0.53	0.43	0.63	0.68	0.62	0.53	0.59	0.77	0.70	0.59	0.73	0.57	0.63	0.50	0.89	0.70	0.68	0.47	0.45	0.57	1.00	0.47	0.67	0.48	0.56	1.00	0.65	0.53	0.64	0.59	0.58	0.51	0.64	0.49	0.63	0.54	0.41	0.67	0.53	0.49
9021 (SOCS3)	0.39	0.55	0.48	0.43	0.50	0.49	0.68	0.55	0.56	0.47	0.58	0.51	0.59	0.45	0.39	0.41	0.54	0.46	0.33	0.41	0.60	0.47	1.00	0.49	0.45	0.49	0.21	0.42	0.53	0.46	0.44	0.49	0.54	0.48	0.55	0.43	0.50	0.35	0.43	0.54	0.51
867 (CBL)	0.60	0.65	0.46	0.50	0.58	0.55	0.55	0.64	0.71	0.63	0.59	0.66	0.63	0.58	0.48	0.69	0.63	0.61	0.37	0.50	0.59	0.67	0.49	1.00	0.53	0.53	0.82	0.52	0.61	0.55	0.54	0.54	0.54	0.56	0.52	0.58	0.51	0.45	0.61	0.55	0.54
5335 (PLCG1)	0.41	0.62	0.41	0.42	0.53	0.45	0.53	0.62	0.59	0.47	0.57	0.51	0.58	0.44	0.41	0.44	0.54	0.48	0.31	0.59	0.59	0.48	0.45	0.53	1.00	0.46	0.21	0.44	0.55	0.48	0.46	0.47	0.55	0.52	0.49	0.44	0.48	0.43	0.44	0.53	0.51
4254 (KITLG)	0.39	0.64	0.76	0.77	0.70	0.63	0.55	0.76	0.56	0.47	0.58	0.51	0.60	0.44	0.42	0.54	0.54	0.62	0.70	0.42	0.60	0.56	0.49	0.53	0.46	1.00	0.21	0.56	0.54	0.60	0.78	0.89	0.54	0.62	0.75	0.45	0.66	0.36	0.44	0.55	0.52
64344 (HIF3A)	1.00	0.21	0.21	0.21	0.21	0.21	0.21	0.21	1.00	1.00	0.28	1.00	0.21	1.00	0.21	1.00	1.00	0.21	0.17	0.21	0.21	1.00	0.21	0.82	0.21	0.21	1.00	0.21	0.21	0.21	0.21	0.21	0.17	0.21	0.21	0.82	0.21	0.21	1.00	0.21	0.17
695 (BTK)	0.41	0.56	0.39	0.66	0.74	0.64	0.49	0.62	0.54	0.47	0.59	0.52	0.58	0.45	0.43	0.66	0.52	0.73	0.54	0.41	0.53	0.65	0.42	0.52	0.44	0.56	0.21	1.00	0.48	0.83	0.60	0.58	0.48	0.66	0.45	0.45	0.45	0.37	0.45	0.54	0.44
10019 (SH2B3)	0.42	0.69	0.45	0.46	0.53	0.47	0.63	0.58	0.60	0.51	0.61	0.54	0.70	0.46	0.41	0.50	0.61	0.52	0.35	0.50	0.74	0.53	0.53	0.61	0.55	0.54	0.21	0.48	1.00	0.57	0.56	0.52	0.66	0.55	0.57	0.46	0.56	0.41	0.47	0.67	0.69
7006 (TEC)	0.40	0.63	0.41	0.64	0.71	0.64	0.56	0.61	0.57	0.48	0.61	0.52	0.61	0.44	0.43	0.66	0.56	0.75	0.55	0.44	0.63	0.64	0.46	0.55	0.48	0.60	0.21	0.83	0.57	1.00	0.63	0.61	0.56	0.67	0.51	0.46	0.50	0.38	0.45	0.57	0.55
2549 (GAB1)	0.40	0.54	0.40	0.66	0.63	0.63	0.53	0.77	0.55	0.47	0.57	0.51	0.67	0.43	0.43	0.59	0.54	0.65	0.47	0.42	0.58	0.59	0.44	0.54	0.46	0.78	0.21	0.60	0.56	0.63	1.00	0.81	0.52	0.64	0.48	0.46	0.47	0.37	0.44	0.53	0.49
8660 (IRS2)	0.41	0.67	0.68	0.75	0.70	0.64	0.54	0.78	0.55	0.47	0.57	0.51	0.57	0.45	0.44	0.57	0.53	0.64	0.63	0.44	0.57	0.58	0.49	0.54	0.47	0.89	0.21	0.58	0.52	0.61	0.81	1.00	0.51	0.62	0.67	0.46	0.61	0.40	0.44	0.53	0.50
1440 (CSF3)	0.43	0.59	0.47	0.44	0.54	0.52	0.72	0.54	0.58	0.47	0.69	0.53	0.60	0.43	0.38	0.50	0.58	0.54	0.48	0.49	0.72	0.51	0.54	0.54	0.55	0.54	0.17	0.48	0.66	0.56	0.52	0.51	1.00	0.58	0.55	0.42	0.54	0.43	0.43	0.62	0.83
1432 (MAPK14)	0.45	0.54	0.45	0.64	0.71	0.83	0.53	0.64	0.61	0.50	0.57	0.55	0.57	0.48	0.46	0.65	0.56	0.69	0.49	0.50	0.57	0.64	0.48	0.56	0.52	0.62	0.21	0.66	0.55	0.67	0.64	0.62	0.58	1.00	0.50	0.49	0.50	0.43	0.47	0.55	0.47
7410 (VAV2)	0.41	0.72	0.86	0.58	0.60	0.50	0.58	0.69	0.57	0.49	0.59	0.52	0.69	0.46	0.41	0.46	0.56	0.48	0.57	0.53	0.62	0.49	0.55	0.52	0.49	0.75	0.21	0.45	0.57	0.51	0.48	0.67	0.55	0.50	1.00	0.45	0.69	0.39	0.45	0.57	0.53
1387 (CREBBP)	0.72	0.48	0.41	0.44	0.50	0.47	0.47	0.53	0.70	0.68	0.53	0.70	0.54	0.74	0.79	0.58	0.67	0.49	0.28	0.42	0.48	0.63	0.43	0.58	0.44	0.45	0.82	0.45	0.46	0.46	0.46	0.46	0.42	0.49	0.45	1.00	0.47	0.50	0.70	0.46	0.39
5906 (RAP1A)	0.41	0.62	0.68	0.53	0.56	0.46	0.56	0.61	0.56	0.48	0.59	0.53	0.60	0.45	0.42	0.45	0.55	0.48	0.48	0.44	0.61	0.54	0.50	0.51	0.48	0.66	0.21	0.45	0.56	0.50	0.47	0.61	0.54	0.50	0.69	0.47	1.00	0.39	0.45	0.56	0.52
10987 (COPS5)	0.44	0.47	0.34	0.37	0.46	0.39	0.43	0.53	0.53	0.46	0.53	0.49	0.57	0.52	0.47	0.35	0.51	0.43	0.24	0.40	0.46	0.41	0.35	0.45	0.43	0.36	0.21	0.37	0.41	0.38	0.37	0.40	0.43	0.43	0.39	0.50	0.39	1.00	0.42	0.43	0.38
4790 (NFKB1)	0.85	0.49	0.41	0.42	0.49	0.42	0.47	0.54	0.80	0.86	0.57	0.80	0.58	0.84	0.52	0.67	0.81	0.45	0.25	0.42	0.50	0.67	0.43	0.61	0.44	0.44	1.00	0.45	0.47	0.45	0.44	0.44	0.43	0.47	0.45	0.70	0.45	0.42	1.00	0.50	0.40
2057 (EPOR)	0.45	0.58	0.47	0.63	0.54	0.48	0.62	0.59	0.59	0.52	0.64	0.56	0.71	0.48	0.42	0.51	0.61	0.52	0.32	0.57	0.71	0.53	0.54	0.55	0.53	0.55	0.21	0.54	0.67	0.57	0.53	0.53	0.62	0.55	0.57	0.46	0.56	0.43	0.50	1.00	0.62
7066 (THPO)	0.37	0.62	0.43	0.41	0.51	0.42	0.67	0.53	0.52	0.46	0.65	0.47	0.60	0.38	0.37	0.47	0.54	0.55	0.42	0.43	0.79	0.49	0.51	0.54	0.51	0.52	0.17	0.44	0.69	0.55	0.49	0.50	0.83	0.47	0.53	0.39	0.52	0.38	0.40	0.62	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
EPO	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	6	RT-qPCR	Western US	C57BL/6 mice	–7	7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
EPO	yellow-rumped warblers (Setophaga coronata)	Blood	-	3000 m	None	upregulated	-	RT-PCR	None	Setophaga coronata	-	Soldier exposed to high altitude compared to their low altitude profile	30266786
EPO	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	5.2	RT-qPCR	Western US	C57BL/6 mice	–7	7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
EPO	Human	Blood	3-10% Oxygen	5800 m	2 hours	upregulated	-	-	-	-	-	Soldier exposed to high altitude compared to their low altitude profile	http://dx.doi.org/10.4172/jpb.S3-004

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
MAX	4149	EPO	2056	distal	22955619	TRANSFAC
GATA2	2624	EPO	2056	distal	22955619	TRANSFAC
TBP	6908	EPO	2056	distal	22955619	TRANSFAC
TAF7	6879	EPO	2056	distal	22955619	TRANSFAC
EP300	2033	EPO	2056	distal	22955619	TRANSFAC
HEY1	23462	EPO	2056	distal	22955619	TRANSFAC
CEBPB	1051	EPO	2056	distal	22955619	TRANSFAC
EGR1	1958	EPO	2056	distal	22955619	TRANSFAC
SPI1	6688	EPO	2056	distal	22955619	TRANSFAC
E2F6	1876	EPO	2056	distal	22955619	TRANSFAC
JUND	3727	EPO	2056	distal	22955619	TRANSFAC
TAL1	6886	EPO	2056	distal	22955619	TRANSFAC
HDAC2	3066	EPO	2056	distal	22955619	TRANSFAC
MXI1	4601	EPO	2056	distal	22955619	TRANSFAC
GATA1	2623	EPO	2056	Repression	17344317	TRUSST
NCOA1	8648	EPO	2056	Unknown	17455323	TRUSST
GATA3	2625	EPO	2056	Activation	22753726	TRUSST
HIF1A	3091	EPO	2056	Activation	16246168	TRUSST
ARNT	405	EPO	2056	Unknown	11704867	TRUSST
SMAD4	4089	EPO	2056	Unknown	16757577	TRUSST
NCOA3	8202	EPO	2056	Unknown	17455323	TRUSST
SP1	6667	EPO	2056	Activation	20971808	TRUSST
SMAD3	4088	EPO	2056	Activation	21700680	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT022112	hsa-miR-125b-5p	Homo sapiens	EPO	2056	Homo sapiens	Luciferase reporter assay	Functional MTI	24165569

Gene Ontology

ID	GO ID	GO Term	GO Type
2056	GO:0018105	peptidyl-serine phosphorylation	GOTERM_BP_DIRECT
2056	GO:0030218	erythrocyte differentiation	GOTERM_BP_DIRECT
2056	GO:0007165	signal transduction	GOTERM_BP_DIRECT
2056	GO:0048678	response to axon injury	GOTERM_BP_DIRECT
2056	GO:0055093	response to hyperoxia	GOTERM_BP_DIRECT
2056	GO:0006953	acute-phase response	GOTERM_BP_DIRECT
2056	GO:0008015	blood circulation	GOTERM_BP_DIRECT
2056	GO:0045893	positive regulation of transcription	GOTERM_BP_DIRECT
2056	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	GOTERM_BP_DIRECT
2056	GO:0009986	cell surface	GOTERM_CC_DIRECT
2056	GO:0006915	apoptotic process	GOTERM_BP_DIRECT
2056	GO:0005128	cytokine activity	GOTERM_MF_DIRECT
2056	GO:0005179	hormone activity	GOTERM_MF_DIRECT
2056	GO:0043249	erythrocyte maturation	GOTERM_BP_DIRECT
2056	GO:0071548	response to dexamethasone	GOTERM_BP_DIRECT
2056	GO:2001258	negative regulation of cation channel activity	GOTERM_BP_DIRECT
2056	GO:0005615	extracellular space	GOTERM_CC_DIRECT
2056	GO:0007568	aging	GOTERM_BP_DIRECT
2056	GO:0051602	response to electrical stimulus	GOTERM_BP_DIRECT
2056	GO:0070555	response to interleukin-1	GOTERM_BP_DIRECT
2056	GO:0007566	embryo implantation	GOTERM_BP_DIRECT
2056	GO:0042541	hemoglobin biosynthetic process	GOTERM_BP_DIRECT
2056	GO:0045740	positive regulation of DNA replication	GOTERM_BP_DIRECT
2056	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GOTERM_BP_DIRECT
2056	GO:0001666	response to hypoxia	GOTERM_BP_DIRECT
2056	GO:0032496	response to lipopolysaccharide	GOTERM_BP_DIRECT
2056	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	GOTERM_BP_DIRECT
2056	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
2056	GO:1902251	negative regulation of erythrocyte apoptotic process	GOTERM_BP_DIRECT
2056	GO:0030295	sphingolipid activator protein activity	GOTERM_MF_DIRECT
2056	GO:0009651	response to salt stress	GOTERM_BP_DIRECT
2056	GO:0010976	positive regulation of neuron projection development	GOTERM_BP_DIRECT
2056	GO:0033189	response to vitamin A	GOTERM_BP_DIRECT
2056	GO:0033574	response to testosterone	GOTERM_BP_DIRECT
2056	GO:0005515	protein binding	GOTERM_MF_DIRECT
2056	GO:0046579	positive regulation of Ras protein signal transduction	GOTERM_BP_DIRECT
2056	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GOTERM_BP_DIRECT
2056	GO:0071474	cellular hyperosmotic response	GOTERM_BP_DIRECT
2056	GO:0044297	cell body	GOTERM_CC_DIRECT
2056	GO:0008284	positive regulation of cell proliferation	GOTERM_BP_DIRECT
2056	GO:0032147	activation of protein kinase activity	GOTERM_BP_DIRECT
2056	GO:0005576	extracellular region	GOTERM_CC_DIRECT
2056	GO:0006357	regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
2056	GO:0010523	negative regulation of calcium ion transport into cytosol	GOTERM_BP_DIRECT
2056	GO:0033033	negative regulation of myeloid cell apoptotic process	GOTERM_BP_DIRECT
2056	GO:0042104	positive regulation of activated T cell proliferation	GOTERM_BP_DIRECT
2056	GO:0043627	response to estrogen	GOTERM_BP_DIRECT
2056	GO:1901215	negative regulation of neuron death	GOTERM_BP_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
2056	hsa04060	Cytokine-cytokine receptor interaction
2056	hsa04066	HIF-1 signaling pathway
2056	hsa04151	PI3K-Akt signaling pathway
2056	hsa04640	Hematopoietic cell lineage
2056	hsa04630	Jak-STAT signaling pathway

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
EPO	2056	Anemia	C0002871	Disease or Syndrome	0.4	0.425	0.759	disease
EPO	2056	Cognition Disorders	C0009241	Mental or Behavioral Dysfunction	0.3	0.425	0.759	group
EPO	2056	Hemolytic-Uremic Syndrome	C0019061	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Anemia, Microangiopathic	C0002889	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Fatigue	C0015672	Sign or Symptom	0.31	0.425	0.759	phenotype
EPO	2056	Hypertensive disease	C0020538	Disease or Syndrome	0.39	0.425	0.759	group
EPO	2056	Kidney Failure, Acute	C0022660	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	melanoma	C0025202	Neoplastic Process	0.35	0.425	0.759	disease
EPO	2056	Paraneoplastic Syndromes	C0030472	Neoplastic Process	0.3	0.425	0.759	group
EPO	2056	Kidney Failure	C0035078	Disease or Syndrome	0.34	0.425	0.759	disease
EPO	2056	Uremia	C0041948	Disease or Syndrome	0.31	0.425	0.759	disease
EPO	2056	CNS disorder	C0007682	Disease or Syndrome	0.31	0.425	0.759	group
EPO	2056	Experimental Autoimmune Encephalomyelitis	C0014072	Experimental Model of Disease	0.3	0.425	0.759	disease
EPO	2056	Nerve Degeneration	C0027746	Cell or Molecular Dysfunction	0.3	0.425	0.759	phenotype
EPO	2056	Pancytopenia	C0030312	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Poisoning	C0032343	Injury or Poisoning	0.3	0.425	0.759	group
EPO	2056	Sarcoma, Experimental	C0036216	Experimental Model of Disease; Neoplastic Process	0.3	0.425	0.759	disease
EPO	2056	Thrombocytopenia	C0040034	Disease or Syndrome	0.3	0.425	0.759	phenotype
EPO	2056	Status Epilepticus	C0038220	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Cooley's anemia	C0002875	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Kidney Failure, Chronic	C0022661	Disease or Syndrome	0.4	0.425	0.759	disease
EPO	2056	Neoplasm Metastasis	C0027627	Neoplastic Process	0.32	0.425	0.759	phenotype
EPO	2056	Pulmonary Embolism	C0034065	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Hemoglobin F Disease	C0019025	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Sarcoma, Jensen	C0036219	Experimental Model of Disease; Neoplastic Process	0.3	0.425	0.759	disease
EPO	2056	Venous Thrombosis	C0042487	Pathologic Function	0.3	0.425	0.759	phenotype
EPO	2056	Tachycardia, Ventricular	C0042514	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Neoplasm Invasiveness	C0027626	Pathologic Function	0.3	0.425	0.759	phenotype
EPO	2056	Myocardial Diseases, Secondary	C0036529	Disease or Syndrome	0.3	0.425	0.759	group
EPO	2056	Gastric ulcer	C0038358	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Thyroid Neoplasm	C0040136	Neoplastic Process	0.31	0.425	0.759	disease
EPO	2056	Cardiomyopathies, Primary	C0033141	Disease or Syndrome	0.3	0.425	0.759	group
EPO	2056	Shock, Cardiogenic	C0036980	Pathologic Function	0.3	0.425	0.759	phenotype
EPO	2056	beta Thalassemia	C0005283	Disease or Syndrome	0.34	0.425	0.759	disease
EPO	2056	Heart Diseases	C0018799	Disease or Syndrome	0.32	0.425	0.759	group
EPO	2056	Inflammation	C0021368	Pathologic Function	0.3	0.425	0.759	phenotype
EPO	2056	Anemia, Hemolytic	C0002878	Disease or Syndrome	0.33	0.425	0.759	disease
EPO	2056	Calcinosis	C0006663	Pathologic Function	0.3	0.425	0.759	phenotype
EPO	2056	Coronary Arteriosclerosis	C0010054	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Myocardial Infarction	C0027051	Disease or Syndrome	0.37	0.425	0.759	disease
EPO	2056	Ventricular Fibrillation	C0042510	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Anemia, Hemolytic, Acquired	C0002879	Disease or Syndrome	0.3	0.425	0.759	group
EPO	2056	Kidney Diseases	C0022658	Disease or Syndrome	0.36	0.425	0.759	group
EPO	2056	Thrombosis	C0040053	Pathologic Function	0.3	0.425	0.759	phenotype
EPO	2056	Ventricular Septal Defects	C0018818	Congenital Abnormality	0.3	0.425	0.759	group
EPO	2056	Sarcoma, Engelbreth-Holm-Swarm	C0036214	Experimental Model of Disease; Neoplastic Process	0.3	0.425	0.759	disease
EPO	2056	Vascular Diseases	C0042373	Disease or Syndrome	0.3	0.425	0.759	group
EPO	2056	Congenital diaphragmatic hernia	C0235833	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Thrombus	C0087086	Pathologic Function	0.3	0.425	0.759	phenotype
EPO	2056	Thyroid Gland Follicular Adenoma	C0151468	Neoplastic Process	0.3	0.425	0.759	disease
EPO	2056	Tumoral calcinosis	C0263628	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Degenerative Diseases, Central Nervous System	C0270715	Disease or Syndrome	0.3	0.425	0.759	group
EPO	2056	Simple Partial Status Epilepticus	C0751524	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Hematopoetic Myelodysplasia	C2713368	Pathologic Function	0.3	0.425	0.759	disease
EPO	2056	Polyneuropathy	C0152025	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Cardiomyopathies	C0878544	Disease or Syndrome	0.3	0.425	0.759	group
EPO	2056	Neurodegenerative Disorders	C0524851	Disease or Syndrome	0.32	0.425	0.759	group
EPO	2056	Status Epilepticus, Subclinical	C0751522	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Petit mal status	C0270823	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Polyneuropathy, Critical Illness	C0393851	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Brain Injuries, Focal	C0452047	Injury or Poisoning	0.3	0.425	0.759	group
EPO	2056	Coronary Artery Disease	C1956346	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Polyneuropathy, Motor	C0271683	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Polyneuropathy, Familial	C0751448	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Acute Kidney Insufficiency	C1565662	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Thalassemia Intermedia	C0271979	Disease or Syndrome	0.32	0.425	0.759	disease
EPO	2056	Thalassemia Minor	C0085578	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Congenital hernia of foramen of Bochdalek	C0265700	Congenital Abnormality	0.3	0.425	0.759	disease
EPO	2056	Complex Partial Status Epilepticus	C0393734	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 2 (finding)	C2675471	Finding	0.3	0.425	0.759	phenotype
EPO	2056	MYELODYSPLASTIC SYNDROME	C3463824	Neoplastic Process	0.4	0.425	0.759	group
EPO	2056	Lassitude	C0086525	Sign or Symptom	0.3	0.425	0.759	phenotype
EPO	2056	Non-Convulsive Status Epilepticus	C0751523	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Microangiopathic hemolytic anemia	C0221021	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Brain Lacerations	C0272945	Injury or Poisoning	0.3	0.425	0.759	disease
EPO	2056	Pulmonary Thromboembolisms	C0524702	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Deep Vein Thrombosis	C0149871	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Weight decreased	C1262477	Finding	0.3	0.425	0.759	phenotype
EPO	2056	Congenital hernia of foramen of Morgagni	C0265699	Congenital Abnormality	0.3	0.425	0.759	disease
EPO	2056	Grand Mal Status Epilepticus	C0311335	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Thyroid carcinoma	C0549473	Neoplastic Process	0.3	0.425	0.759	disease
EPO	2056	Acquired Polyneuropathy	C0751449	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Degenerative Diseases, Spinal Cord	C0751733	Disease or Syndrome	0.3	0.425	0.759	disease
EPO	2056	Renal Insufficiency	C1565489	Disease or Syndrome	0.32	0.425	0.759	disease
EPO	2056	Injuries, Acute Brain	C0085742	Injury or Poisoning	0.3	0.425	0.759	group
EPO	2056	Brain Injuries	C0270611	Injury or Poisoning	0.3	0.425	0.759	group
EPO	2056	Microcalcification	C0521174	Pathologic Function	0.3	0.425	0.759	phenotype
EPO	2056	Acute kidney injury	C2609414	Injury or Poisoning	0.3	0.425	0.759	disease
EPO	2056	Liver carcinoma	C2239176	Neoplastic Process	0.4	0.425	0.759	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
EPO	2056	ALPHA INTERFERON	CETUXIMAB	CHEMBL1201577	None
EPO	2056	ARSENIC TRIOXIDE	ARSENIC TRIOXIDE	CHEMBL1200978	None
EPO	2056	CHELATORS	None	None	None
EPO	2056	HUMAN CHORIONIC GONADOTROPIN	GONADOTROPIN, CHORIONIC	CHEMBL1201509	None
EPO	2056	INTERLEUKIN-1-ALPHA	None	None	None
EPO	2056	MYCOPHENOLATE MOFETIL	MYCOPHENOLATE MOFETIL	CHEMBL1456	None
EPO	2056	OXYMETHOLONE	OXYMETHOLONE	CHEMBL1200585	None