ALTITUDEOMICSDB

Hypoxia-inducible factor 1-alpha

AltitudeomicsDB

Protein Official symbol	HIF1A
Aliases	HIF1A BHLHE78 MOP1 PASD8
Chromosomal Location	14
Length	826
Uniprot ID	Q16665
EC number	None
Protein family Information(Pfam)	PF11413;PF08778;PF00989;PF08447;
PDB id	1D7G;1H2K;1H2L;1H2M;1L3E;1L8C;1LM8;1LQB;2ILM;3HQR;3HQU;4AJY;4H6J;5JWP;5L9B;5L9V;5LA9;5LAS;6GFX;6GMR;
InterPro ID	IPR011598;IPR001321;IPR014887;IPR021537;IPR036638;IPR001610;IPR000014;IPR035965;IPR013767;IPR013655;
dbSNP	rs11549465 rs11549467 rs1802821

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
PSMC3	PSMC5	0.999
PSMC3	PSMC6	0.999
PSMC5	PSMC1	0.999
PSMC6	PSMC5	0.998
PSMC6	PSMC1	0.998
PSMC3	PSMC1	0.998
TCEB1	TCEB2	0.998
TP53	MDM2	0.997
CDKN1A	TP53	0.996
AKT1	NOS3	0.996
CDKN2A	TP53	0.996
CUL2	TCEB2	0.995
TCEB1	CUL2	0.994
VEGFA	HIF1A	0.994
VEGFA	NOS3	0.993
AKT1	STAT3	0.993
AKT1	TP53	0.993
TCEB1	RBX1	0.993
CUL2	RBX1	0.993
JUN	MAPK3	0.992
TCEB2	RBX1	0.992
HIF1A	HIF1AN	0.992
TCEB1	VHL	0.992
EGFR	STAT3	0.992
AKT1	HSP90AA1	0.991
VEGFA	STAT3	0.991
CREB1	CREBBP	0.991
AKT1	CREB1	0.99
TCEB2	VHL	0.99
CUL2	VHL	0.99
JUN	COPS5	0.99
JUN	TP53	0.99
EGFR	HBEGF	0.989
CDKN2A	MDM2	0.989
HEY2	NOTCH1	0.988
HSP90AA1	NOS3	0.987
CREB1	JUN	0.987
TP53	STAT3	0.986
CREB1	EP300	0.985
EP300	CREBBP	0.984
AKT1	CDKN1A	0.984
HSP90AA1	TP53	0.984
HIF1A	EPO	0.984
HIF1A	CA9	0.983
HIF1A	NAA10	0.983
TP53	EP300	0.983
TP53	CREBBP	0.983
HIF1A	VHL	0.982
AKT1	HIF1A	0.982
EGLN1	VHL	0.982
HIF1A	EGLN1	0.982
CDKN2A	CDKN1A	0.981
STAT3	MAPK3	0.981
P4HB	OS9	0.981
HIF1A	EGLN3	0.981
AKT1	EDN1	0.98
TCEB1	COPS5	0.98
CREB1	MAPK3	0.98
HSP90AA1	EGFR	0.98
VEGFA	JUN	0.979
VEGFA	EGFR	0.979
COPS5	RBX1	0.978
HIF1A	STAT3	0.977
EGLN2	HIF1A	0.977
VEGFA	ARNT	0.977
SP1	TP53	0.976
VHL	EGLN3	0.975
JUN	SMAD3	0.975
AKT1	MDM2	0.974
CDKN1A	JUN	0.974
GNB2L1	HSP90AA1	0.974
SMAD3	EP300	0.973
HIF1A	EGFR	0.973
HSP90AA1	STAT3	0.973
JUN	NR3C1	0.972
CDKN2A	SMAD4	0.971
TCEB1	GNB2L1	0.97
HIF1A	NOS3	0.969
HSP90AA1	NR3C1	0.969
CDKN1A	SMAD3	0.969
CUL2	COPS5	0.969
CITED2	CREBBP	0.968
VHL	RBX1	0.968
LDHA	HIF1A	0.968
COPS5	TP53	0.968
HIF1A	TP53	0.966
UBE2D2	RBX1	0.966
JUN	EP300	0.965
CDKN1A	SP1	0.965
VEGFA	VHL	0.965
EDN1	MAPK3	0.964
HSP90AA1	MAPK3	0.964
SMAD3	MAPK3	0.962
EP300	MDM2	0.962
JUN	NOTCH1	0.962
JUN	SMAD4	0.962
CREB1	EDN1	0.962
TCEB1	EGLN1	0.961
EGLN1	OS9	0.96
VEGFA	HSP90AA1	0.96
AKT1	EP300	0.96
CITED2	EP300	0.96
HIF1A	EP300	0.96
AKT1	ARNT	0.96
NOTCH1	EP300	0.959
AKT1	STAT6	0.959
HIF1A	HSP90AA1	0.958
CDKN1A	SMAD4	0.958
STAT3	EP300	0.957
JUN	CREBBP	0.957
JUN	SP1	0.957
EP300	HDAC7	0.956
ARNT	EPO	0.956
SMAD4	EP300	0.955
TP53	NR3C1	0.955
EDN1	JUN	0.955
VEGFA	CREB1	0.954
TCEB1	EGLN3	0.954
HIF1A	JUN	0.954
CDKN1A	STAT3	0.954
HIF1A	COPS5	0.953
CUL2	EGLN1	0.953
GNB2L1	TCEB2	0.953
EP300	NR3C1	0.953
NOTCH1	CREBBP	0.952
EGLN1	TCEB2	0.952
PSMC3	VHL	0.952
JUN	NOS3	0.952
CDKN1A	EP300	0.952
ARNT	EP300	0.951
AKT1	CREBBP	0.951
HIF1A	OS9	0.951
VEGFA	AKT1	0.951
CREBBP	NR3C1	0.951
SP1	EP300	0.951
VEGFA	EP300	0.951
EGFR	TP53	0.951
PSMC3	TCEB2	0.95
TCEB1	HIF1A	0.949
EDN1	EGFR	0.949
HIF1A	NOTCH1	0.949
HIF1A	TCEB2	0.949
CUL2	HIF1A	0.948
STAT3	CREBBP	0.947
PSMC5	VHL	0.947
TP53	MAPK3	0.946
LDHA	ARNT	0.946
CUL2	EGLN3	0.946
HIF1A	MAPK3	0.945
HIF1A	EDN1	0.945
CREB1	NOS3	0.945
SMAD3	CREBBP	0.945
HIF1A	CREBBP	0.945
CREBBP	MDM2	0.944
PSMC1	VHL	0.944
SMAD4	CREBBP	0.944
SP1	MAPK3	0.944
TCEB2	EGLN3	0.943
CA9	ARNT	0.943
CITED2	HIF1A	0.943
HIF1A	CREB1	0.943
PSMC3	TCEB1	0.942
HSP90AA1	EP300	0.942
HIF1A	MDM2	0.942
MAPK3	NR3C1	0.942
TCEB1	HSP90AA1	0.942
EDN1	NOS3	0.941
CDKN1A	HSP90AA1	0.94
HIF1A	ARNT	0.94
VEGFA	STAT6	0.939
EP300	EPO	0.939
SMAD3	SP1	0.939
CREB1	CDKN1A	0.938
STAT6	TP53	0.938
HIF1A	CDKN2A	0.937
EGFR	MAPK3	0.937
CDKN2A	SMAD3	0.937
TP53	HDAC7	0.937
HIF1A	CDKN1A	0.937
CREBBP	HDAC7	0.937
TCEB1	UBE2D2	0.937
HSP90AA1	TCEB2	0.936
ARNT	CREBBP	0.936
STAT3	RORA	0.936
PSMC6	VHL	0.935
EP300	RORA	0.935
JUN	EPO	0.935
HIF1A	PSMC6	0.934
PSMC3	CUL2	0.934
SMAD4	SP1	0.933
HIF1A	SMAD4	0.933
SMAD3	NR3C1	0.932
TCEB1	PSMC6	0.932
HIF1A	SMAD3	0.932
PSMC3	EGLN3	0.932
HIF1A	SP1	0.932
PSMC3	HIF1A	0.931
OS9	EGLN3	0.931
STAT6	STAT3	0.931
VEGFA	CREBBP	0.93
CA9	EP300	0.93
CREB1	EPO	0.93
COPS5	TCEB2	0.93
CREB1	ARNT	0.929
PSMC5	TCEB2	0.929
HIF1A	NR3C1	0.929
EGLN1	RBX1	0.928
EDN1	EP300	0.928
CREBBP	RBX1	0.928
PSMC3	EGLN1	0.928
CREBBP	EPO	0.928
NOTCH1	RBX1	0.928
EP300	RBX1	0.928
COPS5	VHL	0.928
HIF1A	RBX1	0.927
EGLN2	OS9	0.927
LDHA	EP300	0.927
NOS3	EP300	0.926
ARNT	SP1	0.926
UBE2D2	TCEB2	0.926
HIF1A	PSMC5	0.925
HIF1A	GNB2L1	0.925
COPS5	EP300	0.924
SMAD4	NR3C1	0.924
HIF1A	HBEGF	0.923
JUN	ARNT	0.923
PSMC6	TP53	0.923
HIF1A	PSMC1	0.923
HIF1A	HDAC7	0.922
PSMC5	RBX1	0.921
LDHA	CREB1	0.921
CUL2	UBE2D2	0.921
PSMC6	RBX1	0.921
CDKN1A	STAT6	0.92
NOTCH1	HDAC7	0.92
CDKN1A	COPS5	0.919
PSMC3	TP53	0.919
TCEB1	PSMC5	0.919
COPS5	EPO	0.919
JUN	HDAC7	0.919
ARNT	NOS3	0.919
HIF1A	STAT6	0.919
HIF1A	P4HB	0.919
EGLN3	RBX1	0.919
LDHA	JUN	0.918
VEGFA	COPS5	0.918
PSMC6	CDKN1A	0.918
VEGFA	EPO	0.918
TCEB2	PSMC1	0.918
VEGFA	TP53	0.918
ARNT	COPS5	0.918
HIF1A	RORA	0.917
HEY2	ARNT	0.917
TP53	PSMC1	0.917
STAT6	RORA	0.917
NOTCH1	TP53	0.917
EDN1	ARNT	0.917
PSMC1	RBX1	0.916
HIF1A	UBE2D2	0.916
HIF1A	HEY2	0.916
SMAD4	SMAD3	0.916
PSMC5	TP53	0.915
HSP90AA1	STAT6	0.915
HSP90AA1	HBEGF	0.915
TCEB1	PSMC1	0.915
CA9	CREBBP	0.914
UBE2D2	EGFR	0.913
PSMC3	RBX1	0.913
LDHA	COPS5	0.913
PSMC6	TCEB2	0.912
HEY2	EP300	0.911
CUL2	PSMC6	0.911
AKT1	JUN	0.91
CITED2	ARNT	0.91
CUL2	PSMC1	0.91
CDKN1A	ARNT	0.908
UBE2D2	VHL	0.908
CREB1	COPS5	0.908
EDN1	COPS5	0.908
EGLN2	EGLN1	0.907
ARNT	SMAD3	0.907
UBE2D2	EGLN1	0.906
EGLN2	EGLN3	0.905
EGLN1	EGLN3	0.905
UBE2D2	EGLN3	0.904
CUL2	PSMC5	0.904
PSMC6	EGLN1	0.903
ARNT	SMAD4	0.902
CITED2	HDAC7	0.902
COPS5	NOS3	0.902
PSMC6	EGLN3	0.901
CDKN1A	PSMC5	0.901
EGLN1	PSMC5	0.9
PSMC3	CDKN1A	0.9
HEY2	CREBBP	0.9
ARNT	HDAC7	0.9
CDKN1A	PSMC1	0.9
PSMC1	EGLN3	0.9
PSMC5	EGLN3	0.9
EGLN1	PSMC1	0.9

Gene Ontology Semantic Similarity

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#	5702 (PSMC3)	5705 (PSMC5)	5706 (PSMC6)	6921 (TCEB1)	7157 (TP53)	1026 (CDKN1A)	207 (AKT1)	1029 (CDKN2A)	8453 (CUL2)	7422 (VEGFA)	3725 (JUN)	6923 (TCEB2)	3091 (HIF1A)	1956 (EGFR)	1385 (CREB1)	23493 (HEY2)	3320 (HSP90AA1)	2033 (EP300)	54583 (EGLN1)	6774 (STAT3)	5034 (P4HB)	10987 (COPS5)	112398 (EGLN2)	6667 (SP1)	7428 (VHL)	10399 (GNB2L1)	4088 (SMAD3)	10370 (CITED2)	3939 (LDHA)	7322 (UBE2D2)	1906 (EDN1)	4851 (NOTCH1)	405 (ARNT)	4089 (SMAD4)	1387 (CREBBP)	5700 (PSMC1)	768 (CA9)	5595 (MAPK3)	6778 (STAT6)	10956 (OS9)	4846 (NOS3)	112399 (EGLN3)	4193 (MDM2)	9978 (RBX1)	55662 (HIF1AN)	1839 (HBEGF)	2056 (EPO)	8260 (NAA10)	2908 (NR3C1)	51564 (HDAC7)	6095 (RORA)
5702 (PSMC3)	1.00	0.85	0.96	0.64	0.52	0.47	0.50	0.59	0.62	0.64	0.48	0.71	0.59	0.48	0.45	0.42	0.65	0.42	0.50	0.51	0.46	0.47	0.51	0.49	0.62	0.58	0.51	0.57	0.63	0.56	0.66	0.54	0.52	0.47	0.47	0.83	0.63	0.59	0.56	1.00	0.42	0.55	0.54	0.53	0.52	0.38	0.62	0.40	0.42	0.65	0.45
5705 (PSMC5)	0.85	1.00	0.84	0.62	0.53	0.49	0.49	0.61	0.61	0.61	0.49	0.68	0.62	0.48	0.45	0.47	0.63	0.47	0.52	0.53	0.48	0.49	0.52	0.53	0.67	0.58	0.52	0.57	0.62	0.57	0.65	0.55	0.56	0.46	0.52	0.85	0.62	0.56	0.53	1.00	0.44	0.56	0.53	0.58	0.53	0.40	0.62	0.43	0.44	0.67	0.51
5706 (PSMC6)	0.96	0.84	1.00	0.65	0.52	0.49	0.52	0.60	0.63	0.64	0.49	0.71	0.60	0.49	0.47	0.44	0.65	0.43	0.52	0.52	0.48	0.49	0.53	0.50	0.63	0.59	0.51	0.58	0.64	0.58	0.67	0.56	0.54	0.48	0.48	0.82	0.64	0.60	0.57	1.00	0.44	0.57	0.55	0.55	0.53	0.39	0.63	0.43	0.44	0.66	0.46
6921 (TCEB1)	0.64	0.62	0.65	1.00	0.50	0.48	0.53	0.56	0.83	0.60	0.45	0.70	0.58	0.49	0.41	0.40	0.53	0.47	0.50	0.47	0.46	0.42	0.49	0.47	0.91	0.56	0.48	0.55	0.62	0.90	0.65	0.51	0.49	0.43	0.49	0.51	0.62	0.63	0.49	1.00	0.42	0.54	0.68	0.84	0.51	0.43	0.60	0.48	0.40	0.75	0.43
7157 (TP53)	0.52	0.53	0.52	0.50	1.00	0.54	0.55	0.59	0.52	0.56	0.80	0.53	0.79	0.62	0.76	0.72	0.66	0.59	0.54	0.80	0.54	0.50	0.51	0.78	0.56	0.64	0.79	0.62	0.51	0.52	0.52	0.68	0.73	0.71	0.70	0.55	0.50	0.52	0.73	1.00	0.54	0.49	0.66	0.53	0.55	0.35	0.51	0.47	0.69	0.56	0.74
1026 (CDKN1A)	0.47	0.49	0.49	0.48	0.54	1.00	0.63	0.73	0.55	0.54	0.48	0.56	0.59	0.62	0.40	0.38	0.60	0.43	0.43	0.48	0.40	0.37	0.41	0.44	0.53	0.66	0.50	0.51	0.46	0.53	0.51	0.56	0.44	0.41	0.46	0.42	0.44	0.64	0.43	1.00	0.38	0.42	0.55	0.53	0.45	0.46	0.63	0.40	0.42	0.62	0.40
207 (AKT1)	0.50	0.49	0.52	0.53	0.55	0.63	1.00	0.49	0.51	0.58	0.50	0.49	0.54	0.69	0.44	0.41	0.73	0.47	0.47	0.50	0.44	0.41	0.44	0.48	0.57	0.58	0.50	0.48	0.47	0.53	0.50	0.51	0.48	0.47	0.47	0.45	0.46	0.77	0.47	1.00	0.48	0.45	0.57	0.54	0.51	0.58	0.50	0.46	0.41	0.59	0.42
1029 (CDKN2A)	0.59	0.61	0.60	0.56	0.59	0.73	0.49	1.00	0.56	0.59	0.57	0.62	0.65	0.51	0.47	0.50	0.61	0.47	0.49	0.59	0.55	0.51	0.48	0.57	0.60	0.71	0.58	0.54	0.57	0.52	0.61	0.60	0.58	0.52	0.51	0.64	0.56	0.52	0.52	1.00	0.46	0.51	0.55	0.52	0.53	0.37	0.64	0.40	0.49	0.70	0.53
8453 (CUL2)	0.62	0.61	0.63	0.83	0.52	0.55	0.51	0.56	1.00	0.60	0.48	0.83	0.62	0.52	0.43	0.41	0.56	0.45	0.50	0.48	0.45	0.41	0.49	0.47	0.89	0.57	0.51	0.55	0.60	0.88	0.64	0.53	0.50	0.43	0.48	0.51	0.59	0.59	0.50	1.00	0.41	0.52	0.70	0.89	0.50	0.40	0.60	0.44	0.41	0.70	0.43
7422 (VEGFA)	0.64	0.61	0.64	0.60	0.56	0.54	0.58	0.59	0.60	1.00	0.56	0.62	0.62	0.56	0.53	0.50	0.59	0.48	0.56	0.58	0.57	0.53	0.56	0.55	0.60	0.64	0.57	0.59	0.61	0.58	0.65	0.58	0.61	0.57	0.53	0.57	0.60	0.60	0.59	1.00	0.52	0.58	0.57	0.57	0.59	0.59	0.66	0.51	0.51	0.62	0.52
3725 (JUN)	0.48	0.49	0.49	0.45	0.80	0.48	0.50	0.57	0.48	0.56	1.00	0.50	0.82	0.57	0.89	0.81	0.60	0.60	0.45	0.85	0.53	0.52	0.43	0.85	0.50	0.61	0.85	0.66	0.45	0.47	0.48	0.72	0.83	0.84	0.74	0.54	0.44	0.47	0.77	1.00	0.45	0.43	0.54	0.49	0.48	0.32	0.48	0.40	0.72	0.51	0.81
6923 (TCEB2)	0.71	0.68	0.71	0.70	0.53	0.56	0.49	0.62	0.83	0.62	0.50	1.00	0.65	0.51	0.44	0.42	0.57	0.42	0.53	0.50	0.47	0.44	0.52	0.49	0.67	0.59	0.52	0.59	0.69	0.72	0.71	0.59	0.53	0.45	0.47	0.56	0.69	0.57	0.54	1.00	0.41	0.58	0.57	0.63	0.52	0.39	0.67	0.40	0.43	0.68	0.45
3091 (HIF1A)	0.59	0.62	0.60	0.58	0.79	0.59	0.54	0.65	0.62	0.62	0.82	0.65	1.00	0.59	0.80	0.80	0.62	0.56	0.57	0.83	0.57	0.53	0.54	0.81	0.64	0.65	0.79	0.74	0.59	0.60	0.60	0.77	0.86	0.74	0.70	0.59	0.58	0.57	0.81	1.00	0.50	0.56	0.61	0.60	0.55	0.39	0.59	0.49	0.76	0.66	0.81
1956 (EGFR)	0.48	0.48	0.49	0.49	0.62	0.62	0.69	0.51	0.52	0.56	0.57	0.51	0.59	1.00	0.48	0.48	0.68	0.52	0.47	0.56	0.48	0.43	0.44	0.55	0.54	0.61	0.56	0.51	0.49	0.52	0.49	0.53	0.53	0.53	0.52	0.47	0.46	0.67	0.51	1.00	0.45	0.44	0.57	0.53	0.46	0.59	0.49	0.44	0.50	0.54	0.49
1385 (CREB1)	0.45	0.45	0.47	0.41	0.76	0.40	0.44	0.47	0.43	0.53	0.89	0.44	0.80	0.48	1.00	0.85	0.52	0.54	0.41	0.84	0.42	0.44	0.39	0.82	0.47	0.53	0.81	0.71	0.42	0.41	0.46	0.78	0.78	0.84	0.72	0.44	0.41	0.44	0.85	1.00	0.38	0.39	0.48	0.43	0.43	0.29	0.43	0.35	0.76	0.50	0.80
23493 (HEY2)	0.42	0.47	0.44	0.40	0.72	0.38	0.41	0.50	0.41	0.50	0.81	0.42	0.80	0.48	0.85	1.00	0.51	0.55	0.40	0.80	0.44	0.44	0.38	0.86	0.46	0.52	0.78	0.68	0.41	0.39	0.45	0.68	0.83	0.80	0.75	0.47	0.40	0.41	0.79	1.00	0.40	0.38	0.47	0.43	0.43	0.29	0.42	0.34	0.70	0.49	0.83
3320 (HSP90AA1)	0.65	0.63	0.65	0.53	0.66	0.60	0.73	0.61	0.56	0.59	0.60	0.57	0.62	0.68	0.52	0.51	1.00	0.50	0.52	0.58	0.53	0.52	0.49	0.58	0.57	0.65	0.59	0.52	0.52	0.56	0.54	0.57	0.56	0.55	0.51	0.68	0.52	0.61	0.52	1.00	0.55	0.50	0.66	0.55	0.53	0.45	0.54	0.47	0.49	0.59	0.52
2033 (EP300)	0.42	0.47	0.43	0.47	0.59	0.43	0.47	0.47	0.45	0.48	0.60	0.42	0.56	0.52	0.54	0.55	0.50	1.00	0.42	0.55	0.45	0.47	0.41	0.60	0.51	0.50	0.61	0.53	0.42	0.47	0.44	0.47	0.52	0.56	0.79	0.46	0.42	0.48	0.46	1.00	0.45	0.41	0.53	0.52	0.44	0.34	0.42	0.64	0.46	0.54	0.55
54583 (EGLN1)	0.50	0.52	0.52	0.50	0.54	0.43	0.47	0.49	0.50	0.56	0.45	0.53	0.57	0.47	0.41	0.40	0.52	0.42	1.00	0.46	0.69	0.39	0.93	0.46	0.56	0.55	0.50	0.50	0.55	0.49	0.54	0.48	0.46	0.41	0.44	0.45	0.48	0.50	0.46	1.00	0.53	0.89	0.56	0.50	0.78	0.34	0.50	0.37	0.39	0.58	0.41
6774 (STAT3)	0.51	0.53	0.52	0.47	0.80	0.48	0.50	0.59	0.48	0.58	0.85	0.50	0.83	0.56	0.84	0.80	0.58	0.55	0.46	1.00	0.50	0.46	0.45	0.90	0.52	0.62	0.82	0.64	0.48	0.46	0.51	0.74	0.84	0.84	0.70	0.53	0.47	0.51	0.84	1.00	0.46	0.46	0.52	0.49	0.50	0.33	0.49	0.41	0.81	0.59	0.84
5034 (P4HB)	0.46	0.48	0.48	0.46	0.54	0.40	0.44	0.55	0.45	0.57	0.53	0.47	0.57	0.48	0.42	0.44	0.53	0.45	0.69	0.50	1.00	0.44	0.65	0.52	0.49	0.56	0.52	0.46	0.50	0.45	0.50	0.43	0.53	0.47	0.46	0.52	0.45	0.46	0.44	1.00	0.51	0.70	0.53	0.46	0.60	0.33	0.46	0.36	0.41	0.53	0.47
10987 (COPS5)	0.47	0.49	0.49	0.42	0.50	0.37	0.41	0.51	0.41	0.53	0.52	0.44	0.53	0.43	0.44	0.44	0.52	0.47	0.39	0.46	0.44	1.00	0.38	0.47	0.47	0.53	0.52	0.60	0.42	0.41	0.48	0.39	0.46	0.48	0.50	0.51	0.40	0.43	0.40	1.00	0.40	0.38	0.51	0.44	0.44	0.30	0.43	0.32	0.37	0.51	0.42
112398 (EGLN2)	0.51	0.52	0.53	0.49	0.51	0.41	0.44	0.48	0.49	0.56	0.43	0.52	0.54	0.44	0.39	0.38	0.49	0.41	0.93	0.45	0.65	0.38	1.00	0.45	0.53	0.52	0.49	0.49	0.55	0.47	0.54	0.44	0.46	0.41	0.43	0.44	0.48	0.48	0.44	1.00	0.51	0.85	0.54	0.48	0.81	0.34	0.50	0.36	0.38	0.57	0.40
6667 (SP1)	0.49	0.53	0.50	0.47	0.78	0.44	0.48	0.57	0.47	0.55	0.85	0.49	0.81	0.55	0.82	0.86	0.58	0.60	0.46	0.90	0.52	0.47	0.45	1.00	0.52	0.59	0.81	0.59	0.48	0.46	0.50	0.73	0.86	0.85	0.74	0.56	0.47	0.47	0.79	1.00	0.47	0.45	0.52	0.49	0.50	0.32	0.48	0.41	0.76	0.55	0.87
7428 (VHL)	0.62	0.67	0.63	0.91	0.56	0.53	0.57	0.60	0.89	0.60	0.50	0.67	0.64	0.54	0.47	0.46	0.57	0.51	0.56	0.52	0.49	0.47	0.53	0.52	1.00	0.60	0.53	0.57	0.61	0.88	0.63	0.57	0.54	0.45	0.55	0.55	0.61	0.65	0.53	1.00	0.46	0.56	0.74	0.92	0.54	0.44	0.60	0.52	0.44	0.79	0.49
10399 (GNB2L1)	0.58	0.58	0.59	0.56	0.64	0.66	0.58	0.71	0.57	0.64	0.61	0.59	0.65	0.61	0.53	0.52	0.65	0.50	0.55	0.62	0.56	0.53	0.52	0.59	0.60	1.00	0.61	0.57	0.60	0.55	0.61	0.63	0.60	0.56	0.53	0.59	0.56	0.57	0.58	1.00	0.50	0.54	0.61	0.54	0.56	0.43	0.63	0.53	0.52	0.64	0.54
4088 (SMAD3)	0.51	0.52	0.51	0.48	0.79	0.50	0.50	0.58	0.51	0.57	0.85	0.52	0.79	0.56	0.81	0.78	0.59	0.61	0.50	0.82	0.52	0.52	0.49	0.81	0.53	0.61	1.00	0.63	0.49	0.50	0.50	0.68	0.77	0.83	0.71	0.55	0.48	0.52	0.73	1.00	0.49	0.47	0.59	0.52	0.54	0.35	0.50	0.44	0.71	0.56	0.76
10370 (CITED2)	0.57	0.57	0.58	0.55	0.62	0.51	0.48	0.54	0.55	0.59	0.66	0.59	0.74	0.51	0.71	0.68	0.52	0.53	0.50	0.64	0.46	0.60	0.49	0.59	0.57	0.57	0.63	1.00	0.56	0.52	0.59	0.60	0.64	0.63	0.69	0.51	0.55	0.52	0.68	1.00	0.42	0.51	0.55	0.51	0.51	0.36	0.56	0.44	0.58	0.59	0.61
3939 (LDHA)	0.63	0.62	0.64	0.62	0.51	0.46	0.47	0.57	0.60	0.61	0.45	0.69	0.59	0.49	0.42	0.41	0.52	0.42	0.55	0.48	0.50	0.42	0.55	0.48	0.61	0.60	0.49	0.56	1.00	0.55	0.65	0.53	0.50	0.44	0.46	0.52	0.61	0.54	0.51	1.00	0.46	0.60	0.53	0.53	0.54	0.38	0.61	0.39	0.42	0.65	0.44
7322 (UBE2D2)	0.56	0.57	0.58	0.90	0.52	0.53	0.53	0.52	0.88	0.58	0.47	0.72	0.60	0.52	0.41	0.39	0.56	0.47	0.49	0.46	0.45	0.41	0.47	0.46	0.88	0.55	0.50	0.52	0.55	1.00	0.59	0.49	0.48	0.42	0.49	0.48	0.54	0.60	0.47	1.00	0.42	0.50	0.72	0.88	0.50	0.41	0.54	0.47	0.40	0.72	0.42
1906 (EDN1)	0.66	0.65	0.67	0.65	0.52	0.51	0.50	0.61	0.64	0.65	0.48	0.71	0.60	0.49	0.46	0.45	0.54	0.44	0.54	0.51	0.50	0.48	0.54	0.50	0.63	0.61	0.50	0.59	0.65	0.59	1.00	0.57	0.54	0.47	0.49	0.57	0.65	0.57	0.55	1.00	0.44	0.58	0.53	0.56	0.53	0.47	0.71	0.45	0.45	0.66	0.48
4851 (NOTCH1)	0.54	0.55	0.56	0.51	0.68	0.56	0.51	0.60	0.53	0.58	0.72	0.59	0.77	0.53	0.78	0.68	0.57	0.47	0.48	0.74	0.43	0.39	0.44	0.73	0.57	0.63	0.68	0.60	0.53	0.49	0.57	1.00	0.68	0.67	0.58	0.48	0.50	0.50	0.82	1.00	0.39	0.46	0.51	0.49	0.47	0.38	0.58	0.37	0.67	0.59	0.73
405 (ARNT)	0.52	0.56	0.54	0.49	0.73	0.44	0.48	0.58	0.50	0.61	0.83	0.53	0.86	0.53	0.78	0.83	0.56	0.52	0.46	0.84	0.53	0.46	0.46	0.86	0.54	0.60	0.77	0.64	0.50	0.48	0.54	0.68	1.00	0.79	0.68	0.55	0.49	0.49	0.80	1.00	0.45	0.47	0.51	0.51	0.52	0.35	0.51	0.40	0.70	0.56	0.83
4089 (SMAD4)	0.47	0.46	0.48	0.43	0.71	0.41	0.47	0.52	0.43	0.57	0.84	0.45	0.74	0.53	0.84	0.80	0.55	0.56	0.41	0.84	0.47	0.48	0.41	0.85	0.45	0.56	0.83	0.63	0.44	0.42	0.47	0.67	0.79	1.00	0.69	0.50	0.43	0.47	0.75	1.00	0.44	0.41	0.50	0.43	0.48	0.34	0.45	0.37	0.73	0.48	0.78
1387 (CREBBP)	0.47	0.52	0.48	0.49	0.70	0.46	0.47	0.51	0.48	0.53	0.74	0.47	0.70	0.52	0.72	0.75	0.51	0.79	0.44	0.70	0.46	0.50	0.43	0.74	0.55	0.53	0.71	0.69	0.46	0.49	0.49	0.58	0.68	0.69	1.00	0.49	0.45	0.49	0.64	1.00	0.44	0.44	0.54	0.54	0.47	0.34	0.47	0.67	0.59	0.56	0.71
5700 (PSMC1)	0.83	0.85	0.82	0.51	0.55	0.42	0.45	0.64	0.51	0.57	0.54	0.56	0.59	0.47	0.44	0.47	0.68	0.46	0.45	0.53	0.52	0.51	0.44	0.56	0.55	0.59	0.55	0.51	0.52	0.48	0.57	0.48	0.55	0.50	0.49	1.00	0.50	0.49	0.48	1.00	0.45	0.46	0.54	0.50	0.48	0.34	0.52	0.36	0.43	0.58	0.51
768 (CA9)	0.63	0.62	0.64	0.62	0.50	0.44	0.46	0.56	0.59	0.60	0.44	0.69	0.58	0.46	0.41	0.40	0.52	0.42	0.48	0.47	0.45	0.40	0.48	0.47	0.61	0.56	0.48	0.55	0.61	0.54	0.65	0.50	0.49	0.43	0.45	0.50	1.00	0.53	0.49	1.00	0.41	0.52	0.53	0.53	0.50	0.37	0.60	0.37	0.40	0.65	0.42
5595 (MAPK3)	0.59	0.56	0.60	0.63	0.52	0.64	0.77	0.52	0.59	0.60	0.47	0.57	0.57	0.67	0.44	0.41	0.61	0.48	0.50	0.51	0.46	0.43	0.48	0.47	0.65	0.57	0.52	0.52	0.54	0.60	0.57	0.50	0.49	0.47	0.49	0.49	0.53	1.00	0.54	1.00	0.44	0.50	0.59	0.60	0.51	0.58	0.54	0.48	0.42	0.64	0.43
6778 (STAT6)	0.56	0.53	0.57	0.49	0.73	0.43	0.47	0.52	0.50	0.59	0.77	0.54	0.81	0.51	0.85	0.79	0.52	0.46	0.46	0.84	0.44	0.40	0.44	0.79	0.53	0.58	0.73	0.68	0.51	0.47	0.55	0.82	0.80	0.75	0.64	0.48	0.49	0.54	1.00	1.00	0.40	0.46	0.51	0.48	0.48	0.34	0.52	0.38	0.73	0.56	0.82
10956 (OS9)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00
4846 (NOS3)	0.42	0.44	0.44	0.42	0.54	0.38	0.48	0.46	0.41	0.52	0.45	0.41	0.50	0.45	0.38	0.40	0.55	0.45	0.53	0.46	0.51	0.40	0.51	0.47	0.46	0.50	0.49	0.42	0.46	0.42	0.44	0.39	0.45	0.44	0.44	0.45	0.41	0.44	0.40	1.00	1.00	0.48	0.54	0.46	0.62	0.35	0.41	0.37	0.39	0.48	0.43
112399 (EGLN3)	0.55	0.56	0.57	0.54	0.49	0.42	0.45	0.51	0.52	0.58	0.43	0.58	0.56	0.44	0.39	0.38	0.50	0.41	0.89	0.46	0.70	0.38	0.85	0.45	0.56	0.54	0.47	0.51	0.60	0.50	0.58	0.46	0.47	0.41	0.44	0.46	0.52	0.50	0.46	1.00	0.48	1.00	0.52	0.50	0.70	0.35	0.53	0.36	0.38	0.60	0.41
4193 (MDM2)	0.54	0.53	0.55	0.68	0.66	0.55	0.57	0.55	0.70	0.57	0.54	0.57	0.61	0.57	0.48	0.47	0.66	0.53	0.56	0.52	0.53	0.51	0.54	0.52	0.74	0.61	0.59	0.55	0.53	0.72	0.53	0.51	0.51	0.50	0.54	0.54	0.53	0.59	0.51	1.00	0.54	0.52	1.00	0.76	0.58	0.39	0.51	0.54	0.45	0.68	0.48
9978 (RBX1)	0.53	0.58	0.55	0.84	0.53	0.53	0.54	0.52	0.89	0.57	0.49	0.63	0.60	0.53	0.43	0.43	0.55	0.52	0.50	0.49	0.46	0.44	0.48	0.49	0.92	0.54	0.52	0.51	0.53	0.88	0.56	0.49	0.51	0.43	0.54	0.50	0.53	0.60	0.48	1.00	0.46	0.50	0.76	1.00	0.51	0.41	0.52	0.50	0.41	0.74	0.46
55662 (HIF1AN)	0.52	0.53	0.53	0.51	0.55	0.45	0.51	0.53	0.50	0.59	0.48	0.52	0.55	0.46	0.43	0.43	0.53	0.44	0.78	0.50	0.60	0.44	0.81	0.50	0.54	0.56	0.54	0.51	0.54	0.50	0.53	0.47	0.52	0.48	0.47	0.48	0.50	0.51	0.48	1.00	0.62	0.70	0.58	0.51	1.00	0.38	0.51	0.42	0.42	0.55	0.44
1839 (HBEGF)	0.38	0.40	0.39	0.43	0.35	0.46	0.58	0.37	0.40	0.59	0.32	0.39	0.39	0.59	0.29	0.29	0.45	0.34	0.34	0.33	0.33	0.30	0.34	0.32	0.44	0.43	0.35	0.36	0.38	0.41	0.47	0.38	0.35	0.34	0.34	0.34	0.37	0.58	0.34	0.69	0.35	0.35	0.39	0.41	0.38	1.00	0.43	0.33	0.29	0.44	0.30
2056 (EPO)	0.62	0.62	0.63	0.60	0.51	0.63	0.50	0.64	0.60	0.66	0.48	0.67	0.59	0.49	0.43	0.42	0.54	0.42	0.50	0.49	0.46	0.43	0.50	0.48	0.60	0.63	0.50	0.56	0.61	0.54	0.71	0.58	0.51	0.45	0.47	0.52	0.60	0.54	0.52	1.00	0.41	0.53	0.51	0.52	0.51	0.43	1.00	0.40	0.42	0.63	0.45
8260 (NAA10)	0.40	0.43	0.43	0.48	0.47	0.40	0.46	0.40	0.44	0.51	0.40	0.40	0.49	0.44	0.35	0.34	0.47	0.64	0.37	0.41	0.36	0.32	0.36	0.41	0.52	0.53	0.44	0.44	0.39	0.47	0.45	0.37	0.40	0.37	0.67	0.36	0.37	0.48	0.38	1.00	0.37	0.36	0.54	0.50	0.42	0.33	0.40	1.00	0.34	0.55	0.36
2908 (NR3C1)	0.42	0.44	0.44	0.40	0.69	0.42	0.41	0.49	0.41	0.51	0.72	0.43	0.76	0.50	0.76	0.70	0.49	0.46	0.39	0.81	0.41	0.37	0.38	0.76	0.44	0.52	0.71	0.58	0.42	0.40	0.45	0.67	0.70	0.73	0.59	0.43	0.40	0.42	0.73	1.00	0.39	0.38	0.45	0.41	0.42	0.29	0.42	0.34	1.00	0.52	0.76
51564 (HDAC7)	0.65	0.67	0.66	0.75	0.56	0.62	0.59	0.70	0.70	0.62	0.51	0.68	0.66	0.54	0.50	0.49	0.59	0.54	0.58	0.59	0.53	0.51	0.57	0.55	0.79	0.64	0.56	0.59	0.65	0.72	0.66	0.59	0.56	0.48	0.56	0.58	0.65	0.64	0.56	1.00	0.48	0.60	0.68	0.74	0.55	0.44	0.63	0.55	0.52	1.00	0.50
6095 (RORA)	0.45	0.51	0.46	0.43	0.74	0.40	0.42	0.53	0.43	0.52	0.81	0.45	0.81	0.49	0.80	0.83	0.52	0.55	0.41	0.84	0.47	0.42	0.40	0.87	0.49	0.54	0.76	0.61	0.44	0.42	0.48	0.73	0.83	0.78	0.71	0.51	0.42	0.43	0.82	1.00	0.43	0.41	0.48	0.46	0.44	0.30	0.45	0.36	0.76	0.50	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
HIF1A	Human	Blood	-	3500 m	24 hours	upregulated	1.3	RT-qPCR	The South Atlantic States, USA	Americans	1	Soldier exposed to high altitude compared to their low altitude profile	24183776
HIF1A	Sheep	Heart	60 mm Hg	3820 m	110 day	upregulated	-	Western immunoblotting	CA, United States of America	Time-dated pregnant sheep	-	Soldier exposed to high altitude compared to their low altitude profile	30017521
HIF1A	Human	Blood	-	4000 m	24 hours	upregulated	3.2	RT-qPCR	The South Atlantic States, USA	Americans	1	Soldier exposed to high altitude compared to their low altitude profile	24183776
HIF1A	Human	Blood	-	3000m	24 hours	downregulated	−1.0	RT-qPCR	The South Atlantic States, USA	Americans	1	Soldier exposed to high altitude compared to their low altitude profile	24183776
HIF1A	Human	Blood	3-10% Oxygen	5800 m	2 hours	upregulated	-	-	-	-	-	Soldier exposed to high altitude compared to their low altitude profile	http://dx.doi.org/10.4172/jpb.S3-004
HIF1A	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	20.4	RT-qPCR	Western US	C57BL/6 mice	1.7	7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
HIF1A	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	4.9	RT-qPCR	Western US	C57BL/6 mice	1.7	7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
HIF1A	Human	Human Body	-	4000 m	2 months	upregulated	-	PCR-direct sequencing or TaqMan SNP genotyping assay.	-	Tibetan	-	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	29625625

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
SREBF1	6720	HIF1A	3091	proximal_filtered	22955619	TRANSFAC
HIF1A	3091	AGTR1	185	Unknown	10628750	TRUSST
HIF1A	3091	ALOX5AP	241	Unknown	10657944	TRUSST
HIF1A	3091	BAX	581	Repression	18940792	TRUSST
HIF1A	3091	CCND1	595	Activation	17312387	TRUSST
HIF1A	3091	APEX1	328	Unknown	22792348	TRUSST
HIF1A	3091	ALDOA	226	Unknown	15123725	TRUSST
HIF1A	3091	ALAS2	212	Repression	18031796	TRUSST
HIF1A	3091	KLK3	354	Unknown	9880489	TRUSST
HIF1A	3091	AR	367	Unknown	10022897	TRUSST
HIF1A	3091	ARNT	405	Activation	21099103	TRUSST
HIF1A	3091	ASS1	445	Unknown	19351848	TRUSST
HIF1A	3091	BID	637	Repression	20659323	TRUSST
HIF1A	3091	BNIP3	664	Unknown	18320073	TRUSST
HIF1A	3091	CA9	768	Activation	9113387	TRUSST
HIF1A	3091	CDH1	999	Repression	11287612	TRUSST
HIF1A	3091	CCR7	1236	Unknown	18955504	TRUSST
HIF1A	3091	CTGF	1490	Unknown	18342537	TRUSST
HIF1A	3091	ACE	1636	Unknown	11095974	TRUSST
HIF1A	3091	E2F3	1871	Unknown	11057754	TRUSST
HIF1A	3091	EDNRB	1910	Repression	11592817	TRUSST
HIF1A	3091	HBEGF	1839	Activation	20086032	TRUSST
HIF1A	3091	EDN1	1906	Unknown	14988427	TRUSST
HIF1A	3091	EPO	2056	Activation	16246168	TRUSST
HIF1A	3091	ERCC2	2068	Unknown	11870074	TRUSST
HIF1A	3091	ENO1	2023	Repression	19382146	TRUSST
HIF1A	3091	SLC29A1	2030	Activation	12170778	TRUSST
HIF1A	3091	FGF2	2247	Repression	22865884	TRUSST
HIF1A	3091	GAPDH	2597	Activation	14555651	TRUSST
HIF1A	3091	GCK	2645	Activation	17343826	TRUSST
NFKB1	4790	HIF1A	3091	Repression	19173292	TRUSST
YY1	7528	HIF1A	3091	Repression	22179513	TRUSST
KLF5	688	HIF1A	3091	Repression	2498646	TRUSST
BRCA1	672	HIF1A	3091	Unknown	11313879	TRUSST
NFKB2	4791	HIF1A	3091	Unknown	17915561	TRUSST
HIF3A	64344	HIF1A	3091	Activation	9734357	TRUSST
MITF	4286	HIF1A	3091	Unknown	17938209	TRUSST
FOXO4	4303	HIF1A	3091	Repression	21757709	TRUSST
ZFP36	7538	HIF1A	3091	Repression	1909121	TRUSST
STAT3	6774	HIF1A	3091	Activation	9562250	TRUSST
HIF1A	3091	NR3C1	2908	Activation	10801796	TRUSST
HDAC7	51564	HIF1A	3091	Repression	17182846	TRUSST
LIMD1	8994	HIF1A	3091	Repression	17056544	TRUSST
VHL	7428	HIF1A	3091	Unknown	23595228	TRUSST
HIPK2	28996	HIF1A	3091	Unknown	11846562	TRUSST
USF2	7392	HIF1A	3091	Unknown	23595228	TRUSST
EGR1	1958	HIF1A	3091	Unknown	12432566	TRUSST
SIRT1	23411	HIF1A	3091	Activation	19329434	TRUSST
HSF2	3298	HIF1A	3091	Unknown	10037443	TRUSST
RELA	5970	HIF1A	3091	Activation	14737107	TRUSST
ARNT	405	HIF1A	3091	Repression	21544813	TRUSST
HIF1A	3091	HIF1A	3091	Unknown	11313879	TRUSST
HSF4	3299	HIF1A	3091	Unknown	10037443	TRUSST
HIF1A	3091	NR4A1	3164	Unknown	9729303	TRUSST
HIF1A	3091	LDHA	3939	Activation	21799768	TRUSST
HIF1A	3091	LEP	3952	Activation	10212281	TRUSST
HIF1A	3091	LOX	4015	Unknown	19259613	TRUSST
HIF1A	3091	ITGB2	3689	Repression	9076342	TRUSST
HIF1A	3091	MET	4233	Unknown	10601637	TRUSST
HIF1A	3091	MIF	4282	Activation	19717648	TRUSST
HIF1A	3091	MMP2	4313	Unknown	8670251	TRUSST
HIF1A	3091	MUC3A	4584	Unknown	23000483	TRUSST
HIF1A	3091	MUC1	4582	Activation	11551969	TRUSST
HIF1A	3091	NT5E	4907	Activation	21698120	TRUSST
HIF1A	3091	SERPINE1	5054	Activation	22641097	TRUSST
HIF1A	3091	PFKFB4	5210	Activation	10348353	TRUSST
HIF1A	3091	PGK1	5230	Unknown	15937477	TRUSST
HIF1A	3091	ABCB1	5243	Repression	10455139	TRUSST
HIF1A	3091	PIK3CA	5290	Activation	21132541	TRUSST
HIF1A	3091	PFKFB3	5209	Unknown	21179557	TRUSST
HIF1A	3091	PLAU	5328	Unknown	12032322	TRUSST
HIF1A	3091	PPP1R3C	5507	Unknown	14504408	TRUSST
HIF1A	3091	PPARA	5465	Activation	20506119	TRUSST
HIF1A	3091	CXCL12	6387	Repression	21152868	TRUSST
HIF1A	3091	SLC2A1	6513	Unknown	16261846	TRUSST
HIF1A	3091	SDHB	6390	Repression	16304843	TRUSST
HIF1A	3091	RORA	6095	Unknown	20530581	TRUSST
HIF1A	3091	STAT3	6774	Repression	19940030	TRUSST
HIF1A	3091	TERT	7015	Activation	10629091	TRUSST
HIF1A	3091	TFRC	7037	Unknown	8914017	TRUSST
HIF1A	3091	TGFB3	7043	Unknown	15149733	TRUSST
HIF1A	3091	TLR2	7097	Unknown	17167270	TRUSST
HIF1A	3091	TIMP2	7077	Unknown	10212217	TRUSST
HIF1A	3091	TWIST1	7291	Activation	22706202	TRUSST
HIF1A	3091	VEGFA	7422	Activation	23482931	TRUSST
HIF1A	3091	VEGFB	7423	Activation	9988737	TRUSST
HIF1A	3091	XPC	7508	Unknown	17046972	TRUSST
HIF1A	3091	VIM	7431	Activation	20404171	TRUSST
HIF1A	3091	VHL	7428	Activation	11891324	TRUSST
HIF1A	3091	ZNF217	7764	Activation	8774732	TRUSST
HIF1A	3091	RECK	8434	Unknown	20686504	TRUSST
HIF1A	3091	CXCR4	7852	Unknown	14702349	TRUSST
HIF1A	3091	SOCS1	8651	Activation	12744731	TRUSST
HIF1A	3091	PTGES	9536	Unknown	10510472	TRUSST
HIF1A	3091	ARNT2	9915	Unknown	15302867	TRUSST
HIF1A	3091	TUBB3	10381	Unknown	10707962	TRUSST
HIF1A	3091	TLR6	10333	Unknown	19255092	TRUSST
HIF1A	3091	WASF3	10810	Unknown	23926105	TRUSST
HIF1A	3091	FAM162A	26355	Repression	19117054	TRUSST
HIF1A	3091	SETD2	29072	Unknown	15483224	TRUSST
HIF1A	3091	EGLN1	54583	Unknown	18097593	TRUSST
HIF1A	3091	ACE2	59272	Repression	16158053	TRUSST
HIF1A	3091	EGLN3	112399	Activation	22024429	TRUSST
HIF1A	3091	TWIST2	117581	Unknown	12539223	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT000002	hsa-miR-20a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23911400
MIRT000002	hsa-miR-20a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//Western blot//Northern blot//qRT-PCR	Functional MTI	18632605
MIRT000002	hsa-miR-20a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT000498	hsa-miR-20b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	qRT-PCR//ELISA//ChIP//Western blot	Functional MTI	20232316
MIRT000498	hsa-miR-20b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26612965
MIRT000496	hsa-miR-519c-3p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	20233879
MIRT000498	hsa-miR-20b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT000498	hsa-miR-20b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	qRT-PCR	Functional MTI (Weak)	26793992
MIRT004588	hsa-miR-17-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//Microarray//qRT-PCR//Western blot	Functional MTI	24252850
MIRT004587	hsa-miR-18a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay	Functional MTI	27080303
MIRT004588	hsa-miR-17-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23911400
MIRT004587	hsa-miR-18a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT004587	hsa-miR-18a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT004487	hsa-miR-107	Homo sapiens	HIF1A	3091	Homo sapiens	qRT-PCR//Luciferase reporter assay//Western blot//Northern blot	Functional MTI	20308559
MIRT004588	hsa-miR-17-5p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT004587	hsa-miR-18a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26622381
MIRT004587	hsa-miR-18a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Sequencing	Functional MTI (Weak)	20371350
MIRT005926	hsa-miR-424-5p	Homo sapiens	HIF1A	3091	Homo sapiens	ChIP-seq//Luciferase reporter assay//Microarray//qRT-PCR//Western blot	Functional MTI	20972335
MIRT006138	hsa-miR-199a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay	Functional MTI	26344589
MIRT006138	hsa-miR-199a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay	Functional MTI	27122154
MIRT006138	hsa-miR-199a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	24839982
MIRT006138	hsa-miR-199a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Immunohistochemistry//qRT-PCR//Western blot	Functional MTI	24022342
MIRT006138	hsa-miR-199a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	21847633
MIRT006138	hsa-miR-199a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//Microarray//qRT-PCR//Western blot	Functional MTI	26783726
MIRT006744	hsa-miR-138-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay	Functional MTI	23389731
MIRT006744	hsa-miR-138-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay	Functional MTI	21875287
MIRT007022	hsa-miR-199b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay	Functional MTI	21557766
MIRT028216	hsa-miR-33a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Sequencing	Functional MTI (Weak)	20371350
MIRT028216	hsa-miR-33a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay	Functional MTI	25891797
MIRT038587	hsa-miR-106b-3p	Homo sapiens	HIF1A	3091	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT051936	hsa-let-7b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT054349	hsa-miR-210-3p	Homo sapiens	HIF1A	3091	Homo sapiens	QRTPCR//Western blot	Functional MTI	23618526
MIRT070733	hsa-miR-935	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070728	hsa-miR-6815-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070739	hsa-miR-6511a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070734	hsa-miR-1910-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070742	hsa-miR-93-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Flow//Immunocytochemistry//Next Generation Sequencing (NGS)//qRT-PCR	Functional MTI (Weak)	26815014
MIRT070745	hsa-miR-106b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27325313
MIRT070730	hsa-miR-589-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070731	hsa-miR-889-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070741	hsa-miR-6806-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070743	hsa-miR-106a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27325313
MIRT070740	hsa-miR-6755-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070723	hsa-miR-3668	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070742	hsa-miR-93-5p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT070737	hsa-miR-5094	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070735	hsa-miR-3074-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070742	hsa-miR-93-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Microarray//qRT-PCR	Functional MTI (Weak)	22815788
MIRT070774	hsa-miR-4282	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT070745	hsa-miR-106b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT070750	hsa-miR-519d-3p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT070721	hsa-miR-3121-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT138601	hsa-miR-8055	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT191496	hsa-miR-18b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27220837
MIRT191502	hsa-miR-4735-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT191495	hsa-miR-153-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT191496	hsa-miR-18b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT191495	hsa-miR-153-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT191510	hsa-miR-576-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT191501	hsa-miR-3662	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT191502	hsa-miR-4735-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT191496	hsa-miR-18b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT191501	hsa-miR-3662	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT191495	hsa-miR-153-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	27554040
MIRT279539	hsa-miR-5681b	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT279526	hsa-miR-151a-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT398180	hsa-miR-5692a	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT398180	hsa-miR-5692a	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT398178	hsa-miR-155-5p	Homo sapiens	HIF1A	3091	Homo sapiens	qRT-PCR//Immunohistochemistry//Western blot	Functional MTI	25143000
MIRT437403	hsa-miR-22-3p	Homo sapiens	HIF1A	3091	Homo sapiens	Immunofluorescence//qRT-PCR//Western blot	Functional MTI	24496460
MIRT437916	hsa-miR-21-5p	Homo sapiens	HIF1A	3091	Homo sapiens	ChIP-seq	Functional MTI (Weak)	23726431
MIRT536880	hsa-miR-5089-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT536882	hsa-miR-1322	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT536882	hsa-miR-1322	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT536880	hsa-miR-5089-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT536881	hsa-miR-4662a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT536881	hsa-miR-4662a-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT547979	hsa-miR-4799-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT547976	hsa-miR-4418	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT547980	hsa-miR-4463	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT547978	hsa-miR-217	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT547975	hsa-miR-509-3-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT547977	hsa-miR-6807-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT547974	hsa-miR-509-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT547981	hsa-miR-4499	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557309	hsa-miR-329-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557310	hsa-miR-4748	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557311	hsa-miR-4464	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557315	hsa-miR-940	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557316	hsa-miR-6893-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557313	hsa-miR-34b-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557314	hsa-miR-2682-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557318	hsa-miR-106a-3p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557319	hsa-miR-299-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557312	hsa-miR-449c-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT557317	hsa-miR-6808-5p	Homo sapiens	HIF1A	3091	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT702961	hsa-miR-625-3p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702963	hsa-miR-3609	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702964	hsa-miR-494-3p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702956	hsa-miR-4470	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702958	hsa-miR-558	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702959	hsa-miR-3160-3p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702957	hsa-miR-4487	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702962	hsa-miR-548ah-5p	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702960	hsa-miR-3128	Homo sapiens	HIF1A	3091	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT731849	hsa-miR-433-3p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27815672
MIRT731838	hsa-miR-27a-3p	Homo sapiens	HIF1A	3091	Homo sapiens	ChIP-seq//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26292288
MIRT731348	hsa-miR-142-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	28069592
MIRT732516	hsa-miR-429	Homo sapiens	HIF1A	3091	Homo sapiens	qRT-PCR//Western blot	Functional MTI	25550463
MIRT733004	hsa-miR-338-3p	Homo sapiens	HIF1A	3091	Homo sapiens	Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26260688
MIRT733159	hsa-miR-186-5p	Homo sapiens	HIF1A	3091	Homo sapiens	ChIP-seq//Immunohistochemistry//In situ hybridization//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27159677
MIRT733856	hsa-miR-138-1-3p	Homo sapiens	HIF1A	3091	Homo sapiens	qRT-PCR//Western blot	Functional MTI	27284341
MIRT734225	hsa-miR-145-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Chromatin immunoprecipitation//qRT-PCR	Functional MTI (Weak)	26196183
MIRT734294	hsa-miR-200c-5p	Homo sapiens	HIF1A	3091	Homo sapiens	Flow//Immunocytochemistry//Next Generation Sequencing (NGS)//qRT-PCR	Functional MTI (Weak)	26815014
MIRT734722	hsa-miR-497-3p	Homo sapiens	HIF1A	3091	Homo sapiens	Western blot//Immunohistochemistry	Functional MTI	26718330

Gene Ontology

ID	GO ID	GO Term	GO Type
3091	GO:0003151	outflow tract morphogenesis	GOTERM_BP_DIRECT
3091	GO:0010573	vascular endothelial growth factor production	GOTERM_BP_DIRECT
3091	GO:0016239	positive regulation of macroautophagy	GOTERM_BP_DIRECT
3091	GO:0030502	negative regulation of bone mineralization	GOTERM_BP_DIRECT
3091	GO:0032007	negative regulation of TOR signaling	GOTERM_BP_DIRECT
3091	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GOTERM_BP_DIRECT
3091	GO:0048546	digestive tract morphogenesis	GOTERM_BP_DIRECT
3091	GO:0010634	positive regulation of epithelial cell migration	GOTERM_BP_DIRECT
3091	GO:0014850	response to muscle activity	GOTERM_BP_DIRECT
3091	GO:0032909	regulation of transforming growth factor beta2 production	GOTERM_BP_DIRECT
3091	GO:0006355	regulation of transcription	GOTERM_BP_DIRECT
3091	GO:0042789	mRNA transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
3091	GO:0003700	transcription factor activity	GOTERM_MF_DIRECT
3091	GO:0001666	response to hypoxia	GOTERM_BP_DIRECT
3091	GO:0010870	positive regulation of receptor biosynthetic process	GOTERM_BP_DIRECT
3091	GO:0002052	positive regulation of neuroblast proliferation	GOTERM_BP_DIRECT
3091	GO:0051216	cartilage development	GOTERM_BP_DIRECT
3091	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	GOTERM_BP_DIRECT
3091	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
3091	GO:0070244	negative regulation of thymocyte apoptotic process	GOTERM_BP_DIRECT
3091	GO:0000989	transcription factor activity	GOTERM_MF_DIRECT
3091	GO:0001525	angiogenesis	GOTERM_BP_DIRECT
3091	GO:0001077	transcriptional activator activity	GOTERM_MF_DIRECT
3091	GO:0006089	lactate metabolic process	GOTERM_BP_DIRECT
3091	GO:0019896	axonal transport of mitochondrion	GOTERM_BP_DIRECT
3091	GO:0021987	cerebral cortex development	GOTERM_BP_DIRECT
3091	GO:0032722	positive regulation of chemokine production	GOTERM_BP_DIRECT
3091	GO:0045821	positive regulation of glycolytic process	GOTERM_BP_DIRECT
3091	GO:0061072	iris morphogenesis	GOTERM_BP_DIRECT
3091	GO:0031514	motile cilium	GOTERM_CC_DIRECT
3091	GO:0051879	misfolded protein binding	GOTERM_MF_DIRECT
3091	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
3091	GO:0032963	collagen metabolic process	GOTERM_BP_DIRECT
3091	GO:0001755	neural crest cell migration	GOTERM_BP_DIRECT
3091	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GOTERM_BP_DIRECT
3091	GO:0051000	positive regulation of nitric-oxide synthase activity	GOTERM_BP_DIRECT
3091	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GOTERM_BP_DIRECT
3091	GO:1903599	positive regulation of mitophagy	GOTERM_BP_DIRECT
3091	GO:2001054	negative regulation of mesenchymal cell apoptotic process	GOTERM_BP_DIRECT
3091	GO:0001076	core promoter sequence-specific DNA binding	GOTERM_MF_DIRECT
3091	GO:0042826	histone deacetylase binding	GOTERM_MF_DIRECT
3091	GO:0019901	protein kinase binding	GOTERM_MF_DIRECT
3091	GO:0046982	protein heterodimerization activity	GOTERM_MF_DIRECT
3091	GO:0005829	cytosol	GOTERM_CC_DIRECT
3091	GO:0043565	sequence-specific DNA binding	GOTERM_MF_DIRECT
3091	GO:0001938	positive regulation of endothelial cell proliferation	GOTERM_BP_DIRECT
3091	GO:0006879	cellular iron ion homeostasis	GOTERM_BP_DIRECT
3091	GO:0010628	positive regulation of gene expression	GOTERM_BP_DIRECT
3091	GO:0021502	neural fold elevation formation	GOTERM_BP_DIRECT
3091	GO:0046716	muscle cell cellular homeostasis	GOTERM_BP_DIRECT
3091	GO:0046886	positive regulation of hormone biosynthetic process	GOTERM_BP_DIRECT
3091	GO:0071456	cellular response to hypoxia	GOTERM_BP_DIRECT
3091	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GOTERM_BP_DIRECT
3091	GO:0003705	transcription factor activity	GOTERM_MF_DIRECT
3091	GO:0001922	B-1 B cell homeostasis	GOTERM_BP_DIRECT
3091	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	GOTERM_BP_DIRECT
3091	GO:0035162	embryonic hemopoiesis	GOTERM_BP_DIRECT
3091	GO:0045648	positive regulation of erythrocyte differentiation	GOTERM_BP_DIRECT
3091	GO:0045766	positive regulation of angiogenesis	GOTERM_BP_DIRECT
3091	GO:0045893	positive regulation of transcription	GOTERM_BP_DIRECT
3091	GO:0071347	cellular response to interleukin-1	GOTERM_BP_DIRECT
3091	GO:0003208	cardiac ventricle morphogenesis	GOTERM_BP_DIRECT
3091	GO:0010468	regulation of gene expression	GOTERM_BP_DIRECT
3091	GO:0061298	retina vasculature development in camera-type eye	GOTERM_BP_DIRECT
3091	GO:0045926	negative regulation of growth	GOTERM_BP_DIRECT
3091	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	GOTERM_BP_DIRECT
3091	GO:0070101	positive regulation of chemokine-mediated signaling pathway	GOTERM_BP_DIRECT
3091	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	GOTERM_BP_DIRECT
3091	GO:0001892	embryonic placenta development	GOTERM_BP_DIRECT
3091	GO:0008542	visual learning	GOTERM_BP_DIRECT
3091	GO:0010575	positive regulation of vascular endothelial growth factor production	GOTERM_BP_DIRECT
3091	GO:0071542	dopaminergic neuron differentiation	GOTERM_BP_DIRECT
3091	GO:0035257	dopamine binding	GOTERM_MF_DIRECT
3091	GO:0005515	protein binding	GOTERM_MF_DIRECT
3091	GO:0008134	transcription factor binding	GOTERM_MF_DIRECT
3091	GO:0031625	ubiquitin protein ligase binding	GOTERM_MF_DIRECT
3091	GO:0090575	RNA polymerase II transcription factor complex	GOTERM_CC_DIRECT
3091	GO:0007595	lactation	GOTERM_BP_DIRECT
3091	GO:0042541	hemoglobin biosynthetic process	GOTERM_BP_DIRECT
3091	GO:0042593	glucose homeostasis	GOTERM_BP_DIRECT
3091	GO:1902895	positive regulation of pri-miRNA transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
3091	GO:2000378	negative regulation of reactive oxygen species metabolic process	GOTERM_BP_DIRECT
3091	GO:0001837	epithelial to mesenchymal transition	GOTERM_BP_DIRECT
3091	GO:0006366	transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
3091	GO:0007165	signal transduction	GOTERM_BP_DIRECT
3091	GO:0032364	oxygen homeostasis	GOTERM_BP_DIRECT
3091	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GOTERM_BP_DIRECT
3091	GO:1903715	regulation of aerobic respiration	GOTERM_BP_DIRECT
3091	GO:0001947	heart looping	GOTERM_BP_DIRECT
3091	GO:0006351	transcription	GOTERM_BP_DIRECT
3091	GO:0051541	elastin metabolic process	GOTERM_BP_DIRECT
3091	GO:0060574	intestinal epithelial cell maturation	GOTERM_BP_DIRECT
3091	GO:0001228	transcriptional repressor activity	GOTERM_MF_DIRECT
3091	GO:0019899	enzyme binding	GOTERM_MF_DIRECT
3091	GO:0005667	transcription factor complex	GOTERM_CC_DIRECT
3091	GO:1904115	axon cytoplasm	GOTERM_CC_DIRECT
3091	GO:0035035	phosphatidylinositol 3-kinase regulator activity	GOTERM_MF_DIRECT
3091	GO:0005654	nucleoplasm	GOTERM_CC_DIRECT
3091	GO:0005634	nucleus	GOTERM_CC_DIRECT
3091	GO:0016607	nuclear speck	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
3091	hsa04066	HIF-1 signaling pathway
3091	hsa04919	Thyroid hormone signaling pathway
3091	hsa05200	Pathways in cancer
3091	hsa05211	Renal cell carcinoma
3091	hsa05230	Central carbon metabolism in cancer
3091	hsa05231	Choline metabolism in cancer
3091	hsa05205	Proteoglycans in cancer

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
HIF1A	3091	Malignant neoplasm of breast	C0006142	Neoplastic Process	0.4	0.367	0.793	disease
HIF1A	3091	Anaplastic carcinoma	C0205696	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Undifferentiated carcinoma	C0205698	Neoplastic Process	0.3	0.367	0.793	phenotype
HIF1A	3091	Cardiomegaly	C0018800	Finding	0.3	0.367	0.793	phenotype
HIF1A	3091	Subependymal Giant Cell Astrocytoma	C0205768	Neoplastic Process	0.31	0.367	0.793	disease
HIF1A	3091	Anaplasia	C0002793	Neoplastic Process	0.32	0.367	0.793	disease
HIF1A	3091	Malignant neoplasm of skin	C0007114	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Brain Ischemia	C0007786	Disease or Syndrome	0.51	0.367	0.793	disease
HIF1A	3091	Pulmonary Hypertension	C0020542	Pathologic Function	0.5	0.367	0.793	phenotype
HIF1A	3091	Carcinoma, Spindle-Cell	C0205697	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Heart Failure, Right-Sided	C0235527	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Squamous cell carcinoma of esophagus	C0279626	Neoplastic Process	0.37	0.367	0.793	disease
HIF1A	3091	Juvenile Pilocytic Astrocytoma	C0280783	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Prostatic Neoplasms	C0033578	Neoplastic Process	0.4	0.367	0.793	group
HIF1A	3091	Spinal Cord Injuries	C0037929	Injury or Poisoning	0.3	0.367	0.793	group
HIF1A	3091	Cerebral Hypoxia-Ischemia	C0178540	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Myocardial Reperfusion Injury	C0027055	Pathologic Function	0.3	0.367	0.793	phenotype
HIF1A	3091	Astrocytoma	C0004114	Neoplastic Process	0.37	0.367	0.793	disease
HIF1A	3091	Anaplastic astrocytoma	C0334579	Neoplastic Process	0.32	0.367	0.793	disease
HIF1A	3091	Biliary cirrhosis	C0023892	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Pancreatic Neoplasm	C0030297	Neoplastic Process	0.4	0.367	0.793	disease
HIF1A	3091	Thyroid Gland Follicular Adenoma	C0151468	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Noninfiltrating Intraductal Carcinoma	C0007124	Neoplastic Process	0.32	0.367	0.793	disease
HIF1A	3091	Primary biliary cirrhosis	C0008312	Disease or Syndrome	0.31	0.367	0.793	disease
HIF1A	3091	Glioblastoma	C0017636	Neoplastic Process	0.4	0.367	0.793	disease
HIF1A	3091	Left-Sided Heart Failure	C0023212	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Biliary Cirrhosis, Secondary	C0238065	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Carcinomatosis	C0205699	Neoplastic Process	0.3	0.367	0.793	phenotype
HIF1A	3091	Carcinoma	C0007097	Neoplastic Process	0.3	0.367	0.793	group
HIF1A	3091	Heart failure	C0018801	Disease or Syndrome	0.57	0.367	0.793	disease
HIF1A	3091	Hypertensive disease	C0020538	Disease or Syndrome	0.6	0.367	0.793	group
HIF1A	3091	Thyroid Neoplasm	C0040136	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Skin Neoplasms	C0037286	Neoplastic Process	0.3	0.367	0.793	group
HIF1A	3091	Congenital Heart Defects	C0018798	Congenital Abnormality	0.3	0.367	0.793	group
HIF1A	3091	Hemangioblastoma	C0206734	Neoplastic Process	0.35	0.367	0.793	disease
HIF1A	3091	Cholangitis, Sclerosing	C0008313	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Hyperplasia	C0020507	Pathologic Function	0.31	0.367	0.793	phenotype
HIF1A	3091	Neoplasm Invasiveness	C0027626	Pathologic Function	0.3	0.367	0.793	phenotype
HIF1A	3091	Diffuse Astrocytoma	C0280785	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Congestive heart failure	C0018802	Disease or Syndrome	0.55	0.367	0.793	disease
HIF1A	3091	Lung diseases	C0024115	Disease or Syndrome	0.32	0.367	0.793	group
HIF1A	3091	Radiation Injuries, Experimental	C0034531	Injury or Poisoning	0.3	0.367	0.793	group
HIF1A	3091	Giant Cell Glioblastoma	C0334588	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Intracranial Astrocytoma	C0750936	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Anoxic-Ischemic Encephalopathy	C0752305	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Hypoxia-Ischemia, Brain	C0752308	Disease or Syndrome	0.31	0.367	0.793	disease
HIF1A	3091	Mammary Neoplasms, Human	C1257931	Neoplastic Process	0.3	0.367	0.793	group
HIF1A	3091	Childhood Cerebral Astrocytoma	C0338070	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.4	0.367	0.793	disease
HIF1A	3091	Glioblastoma Multiforme	C1621958	Neoplastic Process	0.4	0.367	0.793	disease
HIF1A	3091	Idiopathic Pulmonary Fibrosis	C1800706	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Spinal Cord Contusion	C0433895	Injury or Poisoning	0.3	0.367	0.793	disease
HIF1A	3091	Atypical Ductal Breast Hyperplasia	C1332347	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Cerebral Astrocytoma	C0750935	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Spinal Cord Laceration	C0433900	Injury or Poisoning	0.3	0.367	0.793	disease
HIF1A	3091	Breast Carcinoma	C0678222	Neoplastic Process	0.4	0.367	0.793	disease
HIF1A	3091	Anoxia-Ischemia, Brain	C0752306	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Spinal Cord transection injury	C0433905	Injury or Poisoning	0.3	0.367	0.793	disease
HIF1A	3091	Mixed oligoastrocytoma	C0547065	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Fibrillary Astrocytoma	C0334582	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Pilocytic Astrocytoma	C0334583	Neoplastic Process	0.31	0.367	0.793	disease
HIF1A	3091	Hypoxic-Ischemic Encephalopathy	C0752304	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Ductal Carcinoma	C1176475	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Mammary Neoplasms	C1458155	Neoplastic Process	0.4	0.367	0.793	group
HIF1A	3091	Primary sclerosing cholangitis	C0566602	Disease or Syndrome	0.31	0.367	0.793	disease
HIF1A	3091	Thyroid carcinoma	C0549473	Neoplastic Process	0.33	0.367	0.793	disease
HIF1A	3091	Cardiac Hypertrophy	C1383860	Pathologic Function	0.3	0.367	0.793	phenotype
HIF1A	3091	Protoplasmic astrocytoma	C0334580	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Multiple Hemangioblastomas	C0751692	Neoplastic Process	0.3	0.367	0.793	group
HIF1A	3091	Heart Decompensation	C1961112	Pathologic Function	0.3	0.367	0.793	phenotype
HIF1A	3091	Complications of Diabetes Mellitus	C0342257	Disease or Syndrome	0.3	0.367	0.793	group
HIF1A	3091	Gemistocytic astrocytoma	C0334581	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Cerebral Ischemia	C0917798	Disease or Syndrome	0.33	0.367	0.793	disease
HIF1A	3091	Grade I Astrocytoma	C1704230	Neoplastic Process	0.3	0.367	0.793	disease
HIF1A	3091	Malignant neoplasm of pancreas	C0346647	Neoplastic Process	0.4	0.367	0.793	disease
HIF1A	3091	Post-Traumatic Myelopathy	C0751515	Injury or Poisoning	0.3	0.367	0.793	disease
HIF1A	3091	Anoxia-Ischemia, Cerebral	C0752307	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Myocardial Failure	C1959583	Disease or Syndrome	0.3	0.367	0.793	disease
HIF1A	3091	Familial erythrocytosis	C0152264	Disease or Syndrome	0.31	0.367	0.793	disease
HIF1A	3091	Mental Depression	C0011570	Mental or Behavioral Dysfunction	0.3	0.367	0.793	disease
HIF1A	3091	Mood Disorders	C0525045	Mental or Behavioral Dysfunction	0.3	0.367	0.793	group
HIF1A	3091	Major Depressive Disorder	C1269683	Mental or Behavioral Dysfunction	0.3	0.367	0.793	disease
HIF1A	3091	Unipolar Depression	C0041696	Mental or Behavioral Dysfunction	0.3	0.367	0.793	disease
HIF1A	3091	Bipolar Disorder	C0005586	Mental or Behavioral Dysfunction	0.3	0.367	0.793	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
HIF1A	3091	COBALT	None	None	None
HIF1A	3091	DEFEROXAMINE	DEFEROXAMINE	CHEMBL556	None
HIF1A	3091	ENMD-1198	CHEMBL1080759	CHEMBL1080759	None
HIF1A	3091	EPO	EPOETIN ALFA	CHEMBL1201565	None
HIF1A	3091	EZN-2968	None	None	antagonist
HIF1A	3091	GELDANAMYCIN	GELDANAMYCIN	CHEMBL278315	None
HIF1A	3091	HIF-1ALPHA	CHEMBL299763	CHEMBL299763	None
HIF1A	3091	HYPERBARIC OXYGEN	None	None	None
HIF1A	3091	None	None	None	None
HIF1A	3091	NITROGLYCERIN	NITROGLYCERIN	CHEMBL730	inhibitor
HIF1A	3091	NOSCAPINE	NOSCAPINE	CHEMBL364713	None
HIF1A	3091	PIMONIDAZOLE	PIMONIDAZOLE	CHEMBL58752	None
HIF1A	3091	PX-478	None	None	None
HIF1A	3091	PX-478	None	None	inhibitor
HIF1A	3091	PROTEASOME INHIBITOR	None	None	None
HIF1A	3091	Sunitinib	SUNITINIB	CHEMBL535	None
HIF1A	3091	SPC/ENZ2968	None	None	None