L-lactate dehydrogenase A chain

AltitudeomicsDB
Protein Official symbol LDHA
Aliases LDHA PIG19
Chromosomal Location  11
Length 332
Uniprot ID P00338
EC number 1.1.1.27
Protein family Information(Pfam) PF02866;PF00056;
PDB id 1I10;4AJP;4JNK;4L4R;4L4S;4M49;4OJN;4OKN;4QO7;4QO8;4QSM;4QT0;4R68;4R69;4RLS;4ZVV;5IXS;5IXY;5W8H;5W8I;5W8J;5W8K;5W8L;5ZJD;5ZJE;5ZJF;6BAD;6BAG;6BAX;6BAZ;6BB0;6BB1;6BB2;6BB3;6MV8;6MVA;
InterPro ID IPR001557;IPR011304;IPR018177;IPR022383;IPR001236;IPR015955;IPR036291;
dbSNP rs748436361 rs200093825

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
GPI G6PD 0.994
H6PD GPI 0.991
JUN COPS5 0.99
GPI PKM 0.987
CREB1 JUN 0.987
CREB1 EP300 0.985
GPI PKLR 0.983
PC PKLR 0.971
LDHA LDHD 0.969
GPI ALDOA 0.969
PC PKM 0.969
LDHA HIF1A 0.968
ALDOA PKM 0.968
LDHA ME2 0.968
JUN EP300 0.965
GPI LDHB 0.964
LDHA PC 0.961
HIF1A EP300 0.96
LDHA PKM 0.96
PC ME2 0.959
G6PD PKM 0.959
H6PD PKM 0.957
PKLR ME2 0.956
LDHB LDHD 0.954
H6PD PKLR 0.954
HIF1A JUN 0.954
HIF1A COPS5 0.953
ARNT EP300 0.951
G6PD PKLR 0.951
ME2 PKM 0.951
LDHB PC 0.947
LDHB G6PD 0.947
LDHA ARNT 0.946
LDHA GPI 0.945
ALDOA PKLR 0.944
LDHB GOT1 0.943
HIF1A CREB1 0.943
H6PD G6PD 0.942
HIF1A ARNT 0.94
PC GOT1 0.938
LDHB ME2 0.937
PC LDHD 0.931
GOT1 GOT2 0.931
CREB1 ARNT 0.929
LDHA GOT1 0.929
PKLR LDHD 0.928
LDHA EP300 0.927
LDHB PKM 0.925
COPS5 EP300 0.924
PKM LDHD 0.923
JUN ARNT 0.923
LDHB GOT2 0.922
LDHA G6PD 0.922
LDHA CREB1 0.921
LDHA GOT2 0.92
ARNT COPS5 0.918
LDHA JUN 0.918
H6PD LDHA 0.913
PC GOT2 0.913
LDHA COPS5 0.913
LDHA ALDOA 0.912
ALDOA G6PD 0.912
ME2 LDHD 0.912
LDHA LDHB 0.912
H6PD LDHB 0.91
CREB1 COPS5 0.908
LDHB PKLR 0.906
LDHA PKLR 0.906
H6PD ALDOA 0.9
Gene Ontology Semantic Similarity
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# 2821 (GPI) 3091 (HIF1A) 1385 (CREB1) 2023 (ENO1) 3939 (LDHA) 3725 (JUN) 5315 (PKM) 226 (ALDOA) 5313 (PKLR) 405 (ARNT) 5091 (PC) 6888 (TALDO1) 2539 (G6PD) 5160 (PDHA1) 3945 (LDHB) 3948 (LDHC) 4200 (ME2) 10987 (COPS5) 2805 (GOT1) 2806 (GOT2) 7167 (TPI1) 2033 (EP300) 197257 (LDHD)
2821 (GPI) 1.00 0.44 0.28 0.36 0.39 0.27 0.36 0.38 0.20 0.32 0.42 0.42 0.35 0.24 0.41 0.18 0.20 0.29 0.17 0.21 0.81 0.30 0.60
3091 (HIF1A) 0.44 1.00 0.79 0.66 0.59 0.78 0.61 0.62 0.16 0.83 0.59 0.59 0.58 0.18 0.60 0.14 0.25 0.59 0.12 0.28 0.63 0.63 1.00
1385 (CREB1) 0.28 0.79 1.00 0.57 0.43 0.89 0.48 0.54 0.16 0.73 0.42 0.42 0.47 0.18 0.47 0.14 0.22 0.49 0.11 0.25 0.44 0.57 1.00
2023 (ENO1) 0.36 0.66 0.57 1.00 0.62 0.65 0.70 0.73 0.20 0.65 0.55 0.55 0.61 0.24 0.58 0.18 0.23 0.54 0.14 0.40 0.55 0.52 1.00
3939 (LDHA) 0.39 0.59 0.43 0.62 1.00 0.45 0.66 0.68 0.18 0.54 0.62 0.62 0.67 0.36 0.92 1.00 0.42 0.46 0.16 0.27 0.61 0.47 1.00
3725 (JUN) 0.27 0.78 0.89 0.65 0.45 1.00 0.54 0.58 0.16 0.78 0.44 0.44 0.50 0.18 0.47 0.14 0.22 0.54 0.10 0.33 0.45 0.63 1.00
5315 (PKM) 0.36 0.61 0.48 0.70 0.66 0.54 1.00 0.74 1.00 0.60 0.58 0.63 0.56 0.24 0.59 0.18 0.23 0.55 0.21 0.50 0.57 0.56 1.00
226 (ALDOA) 0.38 0.62 0.54 0.73 0.68 0.58 0.74 1.00 0.20 0.62 0.63 0.63 0.69 0.24 0.67 0.18 0.24 0.60 0.14 0.40 0.62 0.55 1.00
5313 (PKLR) 0.20 0.16 0.16 0.20 0.18 0.16 1.00 0.20 1.00 0.16 0.24 0.40 0.20 0.24 0.18 0.18 0.21 0.20 0.34 0.34 0.20 0.48 0.16
405 (ARNT) 0.32 0.83 0.73 0.65 0.54 0.78 0.60 0.62 0.16 1.00 0.53 0.53 0.54 0.18 0.55 0.14 0.24 0.49 0.12 0.34 0.54 0.58 1.00
5091 (PC) 0.42 0.59 0.42 0.55 0.62 0.44 0.58 0.63 0.24 0.53 1.00 0.64 0.57 0.27 0.65 0.21 0.27 0.45 0.22 0.30 0.61 0.47 1.00
6888 (TALDO1) 0.42 0.59 0.42 0.55 0.62 0.44 0.63 0.63 0.40 0.53 0.64 1.00 0.57 0.27 0.65 0.21 0.27 0.45 0.34 0.38 0.61 0.52 1.00
2539 (G6PD) 0.35 0.58 0.47 0.61 0.67 0.50 0.56 0.69 0.20 0.54 0.57 0.57 1.00 0.40 0.74 0.66 0.36 0.47 0.14 0.29 0.56 0.48 1.00
5160 (PDHA1) 0.24 0.18 0.18 0.24 0.36 0.18 0.24 0.24 0.24 0.18 0.27 0.27 0.40 1.00 0.36 0.36 0.40 0.24 0.24 0.24 0.24 0.33 0.18
3945 (LDHB) 0.41 0.60 0.47 0.58 0.92 0.47 0.59 0.67 0.18 0.55 0.65 0.65 0.74 0.36 1.00 1.00 0.42 0.48 0.17 0.28 0.63 0.47 1.00
3948 (LDHC) 0.18 0.14 0.14 0.18 1.00 0.14 0.18 0.18 0.18 0.14 0.21 0.21 0.66 0.36 1.00 1.00 0.56 0.18 0.18 0.18 0.18 0.25 0.14
4200 (ME2) 0.20 0.25 0.22 0.23 0.42 0.22 0.23 0.24 0.21 0.24 0.27 0.27 0.36 0.40 0.42 0.56 1.00 0.23 0.20 0.20 0.24 0.23 0.34
10987 (COPS5) 0.29 0.59 0.49 0.54 0.46 0.54 0.55 0.60 0.20 0.49 0.45 0.45 0.47 0.24 0.48 0.18 0.23 1.00 0.16 0.37 0.46 0.53 1.00
2805 (GOT1) 0.17 0.12 0.11 0.14 0.16 0.10 0.21 0.14 0.34 0.12 0.22 0.34 0.14 0.24 0.17 0.18 0.20 0.16 1.00 0.71 0.17 0.19 0.16
2806 (GOT2) 0.21 0.28 0.25 0.40 0.27 0.33 0.50 0.40 0.34 0.34 0.30 0.38 0.29 0.24 0.28 0.18 0.20 0.37 0.71 1.00 0.27 0.35 0.37
7167 (TPI1) 0.81 0.63 0.44 0.55 0.61 0.45 0.57 0.62 0.20 0.54 0.61 0.61 0.56 0.24 0.63 0.18 0.24 0.46 0.17 0.27 1.00 0.47 1.00
2033 (EP300) 0.30 0.63 0.57 0.52 0.47 0.63 0.56 0.55 0.48 0.58 0.47 0.52 0.48 0.33 0.47 0.25 0.23 0.53 0.19 0.35 0.47 1.00 1.00
197257 (LDHD) 0.60 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.16 1.00 1.00 1.00 1.00 0.18 1.00 0.14 0.34 1.00 0.16 0.37 1.00 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
LDHA Mice Blood 8% Oxygen 7600 m 24 hours upregulated 8 RT-qPCR Western US C57BL/6 mice 2.7 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
LDHA Human Muscle biopsies - 3500-4500 m 30 day downregulated - 2-DE Himalayas Tibetan and nepali - Nepali controls residing at 1300m 14734630
LDHA Mice Blood 8% Oxygen 7600 m 24 hours upregulated 4.6 RT-qPCR Western US C57BL/6 mice 2.7 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EBF1 1879 LDHA 3939 distal 22955619 TRANSFAC
MEF2A 4205 LDHA 3939 distal 22955619 TRANSFAC
BCL11A 53335 LDHA 3939 distal 22955619 TRANSFAC
TCF12 6938 LDHA 3939 distal 22955619 TRANSFAC
BATF 10538 LDHA 3939 distal 22955619 TRANSFAC
NR3C1 2908 LDHA 3939 proximal_filtered 22955619 TRANSFAC
NRF1 4899 LDHA 3939 proximal_filtered 22955619 TRANSFAC
MYC 4609 LDHA 3939 proximal_filtered 22955619 TRANSFAC
HIF1A 3091 LDHA 3939 Activation 21799768 TRUSST
ATF1 466 LDHA 3939 Unknown 7930616 TRUSST
JUN 3725 LDHA 3939 Unknown 16498264 TRUSST
HSF1 3297 LDHA 3939 Activation 11956291 TRUSST
SP1 6667 LDHA 3939 Repression 11781715 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT025431 hsa-miR-34a-5p Homo sapiens LDHA 3939 Homo sapiens Luciferase reporter assay Functional MTI 26902416
MIRT025431 hsa-miR-34a-5p Homo sapiens LDHA 3939 Homo sapiens Reporter assay;Proteomics Functional MTI 21566225
MIRT025431 hsa-miR-34a-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT028212 hsa-miR-33a-5p Homo sapiens LDHA 3939 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT036157 hsa-miR-320c Homo sapiens LDHA 3939 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT036678 hsa-miR-935 Homo sapiens LDHA 3939 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT043068 hsa-miR-324-5p Homo sapiens LDHA 3939 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT043959 hsa-miR-378a-3p Homo sapiens LDHA 3939 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT043554 hsa-miR-331-3p Homo sapiens LDHA 3939 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050430 hsa-miR-23a-3p Homo sapiens LDHA 3939 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050430 hsa-miR-23a-3p Homo sapiens LDHA 3939 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 23064179
MIRT051827 hsa-let-7c-5p Homo sapiens LDHA 3939 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT054320 hsa-miR-24-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT054320 hsa-miR-24-3p Homo sapiens LDHA 3939 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 23064179
MIRT054321 hsa-miR-210-3p Homo sapiens LDHA 3939 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 23064179
MIRT265630 hsa-miR-203a-3p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT265634 hsa-miR-4524b-3p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT265632 hsa-miR-4305 Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT332417 hsa-miR-489-3p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT332416 hsa-miR-425-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT332419 hsa-miR-3913-3p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT367770 hsa-miR-4670-3p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT367768 hsa-miR-505-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT474210 hsa-miR-190b Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT474211 hsa-miR-190a-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT504906 hsa-miR-1252-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504904 hsa-miR-4276 Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504908 hsa-miR-410-3p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504907 hsa-miR-5190 Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504905 hsa-miR-190a-3p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT656756 hsa-miR-1304-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656755 hsa-miR-6890-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656750 hsa-miR-4654 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656746 hsa-miR-769-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656754 hsa-miR-4772-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656748 hsa-miR-8057 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656749 hsa-miR-4769-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656753 hsa-miR-4284 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656751 hsa-miR-638 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656752 hsa-miR-4713-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656747 hsa-miR-450b-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT702290 hsa-miR-302a-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702294 hsa-miR-34b-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702293 hsa-miR-577 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702291 hsa-miR-1288-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702292 hsa-miR-383-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702295 hsa-miR-8080 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT732042 hsa-miR-34a-3p Homo sapiens LDHA 3939 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27186405
MIRT732042 hsa-miR-34a-3p Homo sapiens LDHA 3939 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25333573
MIRT733180 hsa-miR-374a-5p Homo sapiens LDHA 3939 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26062441
MIRT734229 hsa-miR-200b-3p Homo sapiens LDHA 3939 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27374173
MIRT741478 hsa-miR-34c-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT743412 hsa-miR-4257 Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT744892 hsa-miR-4466 Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT745402 hsa-miR-449a Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT745434 hsa-miR-449b-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT750608 hsa-miR-548au-3p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT752434 hsa-miR-6134 Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT754766 hsa-miR-675-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT756778 hsa-miR-6815-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT757475 hsa-miR-6847-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT757927 hsa-miR-6865-5p Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT759166 hsa-miR-7150 Homo sapiens LDHA 3939 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT783759 hsa-miR-135a-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783761 hsa-miR-135b-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783993 hsa-miR-186-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784565 hsa-miR-3119 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784601 hsa-miR-3133 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784968 hsa-miR-3616-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785579 hsa-miR-4282 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787482 hsa-miR-548ax Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787449 hsa-miR-548ao-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787679 hsa-miR-5585-5p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787844 hsa-miR-573 Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT790008 hsa-miR-942-3p Homo sapiens LDHA 3939 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
Gene Ontology
ID GO ID GO Term GO Type
3939 GO:0009749 response to glucose GOTERM_BP_DIRECT
3939 GO:0042542 response to hydrogen peroxide GOTERM_BP_DIRECT
3939 GO:0005975 carbohydrate metabolic process GOTERM_BP_DIRECT
3939 GO:0016616 amino acid binding GOTERM_MF_DIRECT
3939 GO:0005829 cytosol GOTERM_CC_DIRECT
3939 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3939 GO:0019752 carboxylic acid metabolic process GOTERM_BP_DIRECT
3939 GO:0016020 membrane GOTERM_CC_DIRECT
3939 GO:0048569 post-embryonic organ development GOTERM_BP_DIRECT
3939 GO:0004459 phosphatidylinositol phospholipase C activity GOTERM_MF_DIRECT
3939 GO:0005515 protein binding GOTERM_MF_DIRECT
3939 GO:0051287 NAD binding GOTERM_MF_DIRECT
3939 GO:0042802 identical protein binding GOTERM_MF_DIRECT
3939 GO:0098641 cadherin binding involved in cell-cell adhesion GOTERM_MF_DIRECT
3939 GO:0019900 kinase binding GOTERM_MF_DIRECT
3939 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
3939 GO:0007584 response to nutrient GOTERM_BP_DIRECT
3939 GO:0005913 cell-cell adherens junction GOTERM_CC_DIRECT
3939 GO:0006089 lactate metabolic process GOTERM_BP_DIRECT
3939 GO:0006090 pyruvate metabolic process GOTERM_BP_DIRECT
3939 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
3939 GO:0005634 nucleus GOTERM_CC_DIRECT
3939 GO:0043627 response to estrogen GOTERM_BP_DIRECT
3939 GO:0051591 response to cAMP GOTERM_BP_DIRECT
3939 GO:0021762 substantia nigra development GOTERM_BP_DIRECT
3939 GO:0006096 glycolytic process GOTERM_BP_DIRECT
3939 GO:0005737 cytoplasm GOTERM_CC_DIRECT
3939 GO:0019674 NAD metabolic process GOTERM_BP_DIRECT
3939 GO:0042493 response to drug GOTERM_BP_DIRECT
3939 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
3939 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
3939 GO:0098609 cell-cell adhesion GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3939 hsa00010 Glycolysis / Gluconeogenesis
3939 hsa00270 Cysteine and methionine metabolism
3939 hsa00620 Pyruvate metabolism
3939 hsa01100 Metabolic pathways
3939 hsa00640 Propanoate metabolism
3939 hsa01130 Biosynthesis of antibiotics
3939 hsa04922 Glucagon signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
LDHA 3939 Myocardial Diseases, Secondary C0036529 Disease or Syndrome 0.3 0.562 0.655 group
LDHA 3939 Cardiomyopathies, Primary C0033141 Disease or Syndrome 0.3 0.562 0.655 group
LDHA 3939 Myoglobinuria C0027080 Finding 0.4 0.562 0.655 phenotype
LDHA 3939 Myocardial Infarction C0027051 Disease or Syndrome 0.3 0.562 0.655 disease
LDHA 3939 Cardiomyopathies C0878544 Disease or Syndrome 0.3 0.562 0.655 group
LDHA 3939 Adenocarcinoma of lung (disorder) C0152013 Neoplastic Process 0.3 0.562 0.655 disease
LDHA 3939 Lactate dehydrogenase deficiency type A C2931743 Disease or Syndrome 0.5 0.562 0.655 disease
LDHA 3939 Rhabdomyolysis C0035410 Pathologic Function 0.4 0.562 0.655 phenotype
LDHA 3939 Ketotic hypoglycemia C0271713 Disease or Syndrome 0.3 0.562 0.655 phenotype
LDHA 3939 Major Depressive Disorder C1269683 Mental or Behavioral Dysfunction 0.3 0.562 0.655 disease
LDHA 3939 Mood Disorders C0525045 Mental or Behavioral Dysfunction 0.3 0.562 0.655 group
LDHA 3939 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.3 0.562 0.655 disease
LDHA 3939 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.3 0.562 0.655 disease
LDHA 3939 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.3 0.562 0.655 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
LDHA 3939 ANTHRACYCLINES None None None