Lactate dehydrogenase B chain

AltitudeomicsDB
Protein Official symbol LDHB
Aliases LDHB
Chromosomal Location  12
Length 334
Uniprot ID P07195
EC number 1.1.1.27
Protein family Information(Pfam) PF02866;PF00056;
PDB id 1I0Z;1T2F;
InterPro ID IPR001557;IPR011304;IPR018177;IPR022383;IPR001236;IPR015955;IPR036291;
dbSNP rs118203897 rs777954556 rs118203896 rs118203895 rs7966339 rs267607212

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
LDHA LDHB 0.994
GPI G6PD 0.994
H6PD GPI 0.991
GPI TALDO1 0.991
GPI PKM 0.987
GPI PKLR 0.983
PC PKLR 0.979
PC PKM 0.978
LDHA PKM 0.977
LDHA ME2 0.971
LDHA LDHD 0.969
PC ME2 0.965
LDHA PC 0.965
GPI LDHB 0.964
PC GOT1 0.96
G6PD PKM 0.959
H6PD TALDO1 0.959
LDHB PKM 0.958
H6PD PKM 0.957
PKLR ME2 0.956
H6PD PKLR 0.954
LDHB LDHD 0.954
LDHB G6PD 0.952
LDHB PC 0.952
ME2 PKM 0.951
LDHC LDHD 0.951
G6PD PKLR 0.951
G6PD TALDO1 0.949
LDHA GPI 0.945
LDHB GOT1 0.944
PC GOT2 0.943
LDHB ME2 0.943
H6PD G6PD 0.942
LDHC ME2 0.942
LDHC PC 0.942
LDHA TALDO1 0.933
TALDO1 PKM 0.932
PC LDHD 0.931
GOT1 GOT2 0.931
LDHC GOT1 0.93
LDHA GOT1 0.93
PKLR LDHD 0.93
LDHC PKLR 0.925
PKM LDHD 0.924
LDHB GOT2 0.923
LDHA G6PD 0.922
LDHB TALDO1 0.921
LDHB PKLR 0.92
LDHA PKLR 0.92
LDHA GOT2 0.92
LDHC GPI 0.917
PKLR TALDO1 0.915
LDHC LDHB 0.914
LDHA LDHC 0.914
H6PD LDHA 0.913
ME2 LDHD 0.912
H6PD LDHC 0.91
H6PD LDHB 0.91
LDHC PKM 0.902
LDHC G6PD 0.902
LDHC TALDO1 0.901
Gene Ontology Semantic Similarity
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# 3939 (LDHA) 2821 (GPI) 5091 (PC) 2539 (G6PD) 3945 (LDHB) 5313 (PKLR) 4200 (ME2) 3948 (LDHC) 6888 (TALDO1) 2805 (GOT1) 5315 (PKM) 197257 (LDHD) 2806 (GOT2)
3939 (LDHA) 1.00 0.39 0.65 0.67 0.92 0.18 0.44 1.00 0.62 0.16 0.66 0.72 0.25
2821 (GPI) 0.39 1.00 0.43 0.49 0.40 0.28 0.25 0.25 0.42 0.21 0.37 0.36 0.26
5091 (PC) 0.65 0.43 1.00 0.65 0.74 0.24 0.26 0.21 0.67 0.20 0.61 0.53 0.29
2539 (G6PD) 0.67 0.49 0.65 1.00 0.74 0.20 0.39 0.66 0.57 0.14 0.56 0.71 0.28
3945 (LDHB) 0.92 0.40 0.74 0.74 1.00 0.18 0.44 1.00 0.65 0.17 0.59 0.74 0.26
5313 (PKLR) 0.18 0.28 0.24 0.20 0.18 1.00 0.21 0.18 0.40 0.34 1.00 0.18 0.34
4200 (ME2) 0.44 0.25 0.26 0.39 0.44 0.21 1.00 0.56 0.26 0.19 0.23 0.43 0.19
3948 (LDHC) 1.00 0.25 0.21 0.66 1.00 0.18 0.56 1.00 0.21 0.18 0.18 0.78 0.18
6888 (TALDO1) 0.62 0.42 0.67 0.57 0.65 0.40 0.26 0.21 1.00 0.34 0.63 0.48 0.39
2805 (GOT1) 0.16 0.21 0.20 0.14 0.17 0.34 0.19 0.18 0.34 1.00 0.21 0.16 0.71
5315 (PKM) 0.66 0.37 0.61 0.56 0.59 1.00 0.23 0.18 0.63 0.21 1.00 0.50 0.48
197257 (LDHD) 0.72 0.36 0.53 0.71 0.74 0.18 0.43 0.78 0.48 0.16 0.50 1.00 0.26
2806 (GOT2) 0.25 0.26 0.29 0.28 0.26 0.34 0.19 0.18 0.39 0.71 0.48 0.26 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
LDHB Toad Heart - 3464 m 33 day downregulated -2.004165443 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
MYC 4609 LDHB 3945 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT019875 hsa-miR-375 Homo sapiens LDHB 3945 Homo sapiens Microarray//qRT-PCR//Western blot Functional MTI 22752059
MIRT019875 hsa-miR-375 Homo sapiens LDHB 3945 Homo sapiens Microarray Functional MTI (Weak) 20215506
MIRT019875 hsa-miR-375 Homo sapiens LDHB 3945 Homo sapiens Immunohistochemistry//Luciferase reporter assay//Microarray//QRTPCR Functional MTI 23497265
MIRT038609 hsa-miR-186-3p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039024 hsa-miR-766-3p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT040197 hsa-miR-615-3p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT043198 hsa-miR-324-5p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT045350 hsa-miR-185-5p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046914 hsa-miR-221-3p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048133 hsa-miR-197-3p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048552 hsa-miR-100-5p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050573 hsa-miR-20a-5p Homo sapiens LDHB 3945 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT054322 hsa-miR-23a-3p Homo sapiens LDHB 3945 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 23064179
MIRT054323 hsa-miR-24-3p Homo sapiens LDHB 3945 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 23064179
MIRT054324 hsa-miR-210-3p Homo sapiens LDHB 3945 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 23064179
Gene Ontology
ID GO ID GO Term GO Type
3945 GO:0005975 carbohydrate metabolic process GOTERM_BP_DIRECT
3945 GO:0019674 NAD metabolic process GOTERM_BP_DIRECT
3945 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3945 GO:0045121 membrane raft GOTERM_CC_DIRECT
3945 GO:0005737 cytoplasm GOTERM_CC_DIRECT
3945 GO:0042802 identical protein binding GOTERM_MF_DIRECT
3945 GO:0043209 myelin sheath GOTERM_CC_DIRECT
3945 GO:0005829 cytosol GOTERM_CC_DIRECT
3945 GO:0005515 protein binding GOTERM_MF_DIRECT
3945 GO:0016020 membrane GOTERM_CC_DIRECT
3945 GO:0006089 lactate metabolic process GOTERM_BP_DIRECT
3945 GO:0051287 NAD binding GOTERM_MF_DIRECT
3945 GO:0005739 mitochondrion GOTERM_CC_DIRECT
3945 GO:0006090 pyruvate metabolic process GOTERM_BP_DIRECT
3945 GO:0019900 kinase binding GOTERM_MF_DIRECT
3945 GO:0019752 carboxylic acid metabolic process GOTERM_BP_DIRECT
3945 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
3945 GO:0004459 phosphatidylinositol phospholipase C activity GOTERM_MF_DIRECT
3945 GO:0016616 malate dehydrogenase activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3945 hsa00010 Glycolysis / Gluconeogenesis
3945 hsa00270 Cysteine and methionine metabolism
3945 hsa00620 Pyruvate metabolism
3945 hsa00640 Propanoate metabolism
3945 hsa01130 Biosynthesis of antibiotics
3945 hsa01100 Metabolic pathways
3945 hsa04922 Glucagon signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
LDHB 3945 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.633 0.414 group
LDHB 3945 Chromophobe Renal Cell Carcinoma C1266042 Neoplastic Process 0.3 0.633 0.414 disease
LDHB 3945 Collecting Duct Carcinoma of the Kidney C1266044 Neoplastic Process 0.3 0.633 0.414 disease
LDHB 3945 Renal Cell Carcinoma C0007134 Neoplastic Process 0.3 0.633 0.414 disease
LDHB 3945 Acute Coronary Syndrome C0948089 Disease or Syndrome 0.3 0.633 0.414 disease
LDHB 3945 Papillary Renal Cell Carcinoma C1306837 Neoplastic Process 0.3 0.633 0.414 disease
LDHB 3945 Neoplasm Invasiveness C0027626 Pathologic Function 0.3 0.633 0.414 phenotype
LDHB 3945 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.633 0.414 disease
LDHB 3945 Atypical Ductal Breast Hyperplasia C1332347 Neoplastic Process 0.3 0.633 0.414 disease
LDHB 3945 Inborn Errors of Metabolism C0025521 Congenital Abnormality; Disease or Syndrome 0.3 0.633 0.414 group
LDHB 3945 Prostatic Neoplasms C0033578 Neoplastic Process 0.3 0.633 0.414 group
LDHB 3945 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.31 0.633 0.414 disease
LDHB 3945 Sarcomatoid Renal Cell Carcinoma C1266043 Neoplastic Process 0.3 0.633 0.414 disease
LDHB 3945 Conventional (Clear Cell) Renal Cell Carcinoma C0279702 Neoplastic Process 0.3 0.633 0.414 disease
LDHB 3945 Breast Carcinoma C0678222 Neoplastic Process 0.33 0.633 0.414 disease
LDHB 3945 Mammary Neoplasms C1458155 Neoplastic Process 0.3 0.633 0.414 group
LDHB 3945 Malignant neoplasm of breast C0006142 Neoplastic Process 0.33 0.633 0.414 disease
LDHB 3945 Noninfiltrating Intraductal Carcinoma C0007124 Neoplastic Process 0.31 0.633 0.414 disease
LDHB 3945 Lactate Dehydrogenase B Deficiency C3279904 Disease or Syndrome 0.6 0.633 0.414 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types