Carbonic anhydrase 9

AltitudeomicsDB
Protein Official symbol CA9
Aliases CA9 G250 MN
Chromosomal Location  9
Length 459
Uniprot ID Q16790
EC number 4.2.1.1
Protein family Information(Pfam) PF00194;
PDB id 2HKF;3IAI;5DVX;5FL4;5FL5;5FL6;6FE0;6FE1;6FE2;6G98;6G9U;6QN2;6QN5;6QN6;6QUT;6RQN;6RQQ;6RQU;6RQW;
InterPro ID IPR018429;IPR001148;IPR036398;IPR023561;IPR018338;
dbSNP rs2071676 rs3829078

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
EP300 CREBBP 0.984
HIF1A CA9 0.983
CA9 EPAS1 0.969
HIF1A EP300 0.96
ARNT EP300 0.951
HIF1A CREBBP 0.945
CA9 HIF3A 0.944
CA9 ARNT 0.943
HIF1A ARNT 0.94
ARNT CREBBP 0.936
ARNT EPAS1 0.936
EPAS1 EP300 0.934
CA9 EP300 0.93
HIF3A ARNT 0.926
EPAS1 CREBBP 0.919
HIF3A EP300 0.915
CA9 CREBBP 0.914
HIF3A EPAS1 0.908
HIF3A CREBBP 0.907
HIF1A EPAS1 0.907
HIF1A HIF3A 0.906
Gene Ontology Semantic Similarity
Download Tab separated file
# 2033 (EP300) 3091 (HIF1A) 768 (CA9) 405 (ARNT) 2034 (EPAS1) 64344 (HIF3A) 1387 (CREBBP)
2033 (EP300) 1.00 0.56 0.42 0.52 0.55 0.21 0.79
3091 (HIF1A) 0.56 1.00 0.58 0.86 0.89 1.00 0.70
768 (CA9) 0.42 0.58 1.00 0.49 0.59 0.21 0.45
405 (ARNT) 0.52 0.86 0.49 1.00 0.89 1.00 0.68
2034 (EPAS1) 0.55 0.89 0.59 0.89 1.00 1.00 0.67
64344 (HIF3A) 0.21 1.00 0.21 1.00 1.00 1.00 0.82
1387 (CREBBP) 0.79 0.70 0.45 0.68 0.67 0.82 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CA9 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 7.2 RT-qPCR Western US C57BL/6 mice –3.7 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
CA9 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 8.3 RT-qPCR Western US C57BL/6 mice –3.7 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
CTCF 10664 CA9 768 distal 22955619 TRANSFAC
NR3C1 2908 CA9 768 proximal_filtered 22955619 TRANSFAC
AHR 196 CA9 768 Activation 21132541 TRUSST
ATF4 468 CA9 768 Unknown 21866569 TRUSST
SP1 6667 CA9 768 Unknown 11278818 TRUSST
VHL 7428 CA9 768 Activation 21964930 TRUSST
EP300 2033 CA9 768 Unknown 22102412 TRUSST
EPAS1 2034 CA9 768 Unknown 9265625 TRUSST
HDAC4 9759 CA9 768 Repression 9303434 TRUSST
ARNT 405 CA9 768 Activation 22169226 TRUSST
ETS1 2113 CA9 768 Repression 10569470 TRUSST
SP3 6670 CA9 768 Unknown 11278818 TRUSST
HIF1A 3091 CA9 768 Activation 9113387 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT027439 hsa-miR-98-5p Homo sapiens CA9 768 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT028954 hsa-miR-26b-5p Homo sapiens CA9 768 Homo sapiens Microarray Functional MTI (Weak) 19088304
Gene Ontology
ID GO ID GO Term GO Type
768 GO:0005886 plasma membrane GOTERM_CC_DIRECT
768 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
768 GO:0006730 one-carbon metabolic process GOTERM_BP_DIRECT
768 GO:0002009 morphogenesis of an epithelium GOTERM_BP_DIRECT
768 GO:0033574 response to testosterone GOTERM_BP_DIRECT
768 GO:0004089 carbonate dehydratase activity GOTERM_MF_DIRECT
768 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
768 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GOTERM_BP_DIRECT
768 GO:0042493 response to drug GOTERM_BP_DIRECT
768 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
768 GO:0016323 basolateral plasma membrane GOTERM_CC_DIRECT
768 GO:0015701 bicarbonate transport GOTERM_BP_DIRECT
768 GO:0005730 nucleolus GOTERM_CC_DIRECT
768 GO:0031528 microvillus membrane GOTERM_CC_DIRECT
768 GO:0046903 secretion GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
768 hsa00910 Nitrogen metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CA9 768 Anaplasia C0002793 Neoplastic Process 0.3 0.537 0.586 disease
CA9 768 Hypoxia C0242184 Pathologic Function 0.3 0.537 0.586 phenotype
CA9 768 Hypoxemia C0700292 Finding 0.3 0.537 0.586 phenotype
CA9 768 Ductal Carcinoma C1176475 Neoplastic Process 0.32 0.537 0.586 disease
CA9 768 Noninfiltrating Intraductal Carcinoma C0007124 Neoplastic Process 0.32 0.537 0.586 disease
CA9 768 Anoxia C0003130 Pathologic Function 0.4 0.537 0.586 phenotype
CA9 768 Atypical Ductal Breast Hyperplasia C1332347 Neoplastic Process 0.3 0.537 0.586 disease
CA9 768 Myeloid Leukemia, Chronic C0023473 Neoplastic Process 0.31 0.537 0.586 disease
CA9 768 Anoxemia C0003129 Sign or Symptom 0.3 0.537 0.586 phenotype
CA9 768 Pulmonary Hypertension C0020542 Pathologic Function 0.3 0.537 0.586 phenotype
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
CA9 768 CG250 177LU CG250 177LU CHEMBL3707297 None
CA9 768 CG250 111IN CG250 111IN CHEMBL3707280 None
CA9 768 ETHOXZOLAMIDE ETHOXZOLAMIDE CHEMBL18 inhibitor
CA9 768 GIRENTUXIMAB GIRENTUXIMAB CHEMBL1743027 None
CA9 768 IODINE I 124 GIRENTUXIMAB IODINE I 124 GIRENTUXIMAB CHEMBL2108713 None
CA9 768 Sunitinib SUNITINIB CHEMBL535 None