Endothelial PAS domain-containing protein 1
AltitudeomicsDB
Protein Official symbol |
EPAS1 |
Aliases |
EPAS1 BHLHE73 HIF2A MOP2 PASD2 |
Chromosomal Location |
2 |
Length |
870 |
Uniprot ID |
Q99814 |
EC number |
None |
Protein family Information(Pfam) |
PF11413;PF08778;PF00989;PF08447; |
PDB id |
1P97;2A24;3F1N;3F1O;3F1P;3H7W;3H82;4GHI;4GS9;4PKY;4XT2;5KIZ;5TBM;5UFP;6BVB;6CZW;6D09;6D0B;6D0C;6I7Q;6I7R; |
InterPro ID |
IPR011598;IPR014887;IPR021537;IPR036638;IPR001067;IPR001610;IPR000014;IPR035965;IPR013767;IPR013655; |
dbSNP |
rs137853037 rs137853036 rs137853036 rs59901247 rs61518065 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
PSMC3 |
PSMC6 |
0.999 |
PSMD12 |
PSMD7 |
0.999 |
PSMD12 |
PSMD2 |
0.999 |
PSMD1 |
PSMD7 |
0.999 |
PSMD2 |
PSMD1 |
0.999 |
PSMD12 |
PSMD1 |
0.999 |
PSMC6 |
PSMC2 |
0.999 |
PSMC2 |
PSMD1 |
0.998 |
PSMB4 |
PSMA2 |
0.998 |
SOX2 |
POU5F1 |
0.998 |
PSMC3 |
PSMD2 |
0.998 |
PSMC3 |
PSMD1 |
0.998 |
PSMC3 |
PSMD12 |
0.998 |
PSMC3 |
PSMC2 |
0.998 |
PSMB4 |
PSMB6 |
0.998 |
PSMC2 |
PSMD12 |
0.998 |
PSMC6 |
PSMD12 |
0.998 |
TCEB1 |
TCEB2 |
0.998 |
PSMC2 |
PSMD2 |
0.998 |
POU5F1 |
NANOG |
0.998 |
PSMB6 |
PSMA2 |
0.998 |
PSMD2 |
PSMD7 |
0.998 |
PSMC2 |
PSMA2 |
0.997 |
PSMC6 |
PSMD2 |
0.997 |
PSMC3 |
PSMD7 |
0.997 |
PSMC6 |
PSMD7 |
0.997 |
PSMC2 |
PSMD7 |
0.997 |
PSMC6 |
PSMA2 |
0.997 |
SOX2 |
NANOG |
0.996 |
PSMC2 |
PSMB4 |
0.996 |
PSMC6 |
PSMD1 |
0.996 |
LIN28A |
POU5F1 |
0.996 |
KLF4 |
NANOG |
0.996 |
KLF4 |
SOX2 |
0.995 |
CUL2 |
TCEB2 |
0.995 |
LIN28A |
NANOG |
0.994 |
PSMC6 |
PSMB4 |
0.994 |
KLF4 |
POU5F1 |
0.994 |
TCEB1 |
CUL2 |
0.994 |
VEGFA |
HIF1A |
0.994 |
TCEB1 |
RBX1 |
0.993 |
CUL2 |
RBX1 |
0.993 |
TCEB2 |
RBX1 |
0.992 |
TCEB1 |
VHL |
0.992 |
HIF1A |
HIF1AN |
0.992 |
LIN28A |
SOX2 |
0.992 |
PSMA2 |
PSMD7 |
0.991 |
CUL2 |
VHL |
0.99 |
PSMC3 |
PSMA2 |
0.99 |
PSMC3 |
PSMB4 |
0.99 |
TCEB2 |
VHL |
0.99 |
NANOG |
SALL4 |
0.989 |
POU5F1 |
SALL4 |
0.989 |
KLF4 |
LIN28A |
0.989 |
PSMD1 |
PSMA2 |
0.988 |
PSMB4 |
PSMD7 |
0.988 |
PSMC3 |
PSMB6 |
0.988 |
PSMC6 |
PSMB6 |
0.987 |
PSMD12 |
PSMA2 |
0.986 |
EGLN1 |
EPAS1 |
0.986 |
PSMC2 |
PSMB6 |
0.986 |
PSMD1 |
PSMB4 |
0.986 |
UBC |
UBB |
0.985 |
HIF1A |
EPO |
0.984 |
EP300 |
CREBBP |
0.984 |
HIF1A |
CA9 |
0.983 |
HIF1A |
VHL |
0.982 |
EGLN1 |
VHL |
0.982 |
HIF1A |
EGLN1 |
0.982 |
PSMB6 |
PSMD7 |
0.982 |
PSMD2 |
PSMA2 |
0.982 |
HIF1A |
EGLN3 |
0.981 |
PSMD12 |
PSMB4 |
0.981 |
EP300 |
SIRT1 |
0.98 |
PSMD2 |
PSMB4 |
0.979 |
EGLN2 |
HIF1A |
0.977 |
VEGFA |
ARNT |
0.977 |
LIN28A |
SALL4 |
0.976 |
SOX2 |
SALL4 |
0.975 |
VHL |
EGLN3 |
0.975 |
VEGFA |
EPAS1 |
0.974 |
EPAS1 |
VHL |
0.974 |
PSMD1 |
PSMB6 |
0.973 |
PRDM14 |
POU5F1 |
0.972 |
EGLN2 |
EPAS1 |
0.972 |
PRDM14 |
NANOG |
0.972 |
PSMD12 |
PSMB6 |
0.97 |
EPAS1 |
EPO |
0.969 |
SOX2 |
PRDM14 |
0.969 |
CA9 |
EPAS1 |
0.969 |
CITED2 |
CREBBP |
0.968 |
VHL |
RBX1 |
0.968 |
PSMD2 |
PSMB6 |
0.966 |
VEGFA |
VHL |
0.965 |
UBE2D3 |
RBX1 |
0.963 |
KLF4 |
SMAD2 |
0.963 |
TCEB1 |
UBXN7 |
0.963 |
EPAS1 |
EGLN3 |
0.962 |
TCEB1 |
EGLN1 |
0.961 |
PSMD7 |
PSMD5 |
0.961 |
HIF1A |
EP300 |
0.96 |
CITED2 |
EP300 |
0.96 |
CUL2 |
UBXN7 |
0.96 |
PSMA2 |
RBX1 |
0.958 |
LIN28A |
PRDM14 |
0.957 |
ARNT |
EPO |
0.956 |
SMAD2 |
NANOG |
0.956 |
SMAD4 |
EP300 |
0.955 |
UBC |
UBE2D3 |
0.955 |
SMAD2 |
POU5F1 |
0.954 |
TCEB1 |
EGLN3 |
0.954 |
EP300 |
NR3C1 |
0.953 |
CUL2 |
EGLN1 |
0.953 |
PSMC3 |
VHL |
0.952 |
EP300 |
SMAD2 |
0.952 |
EGLN1 |
TCEB2 |
0.952 |
CREBBP |
NR3C1 |
0.951 |
ARNT |
EP300 |
0.951 |
VEGFA |
EP300 |
0.951 |
SOX2 |
SMAD2 |
0.95 |
PSMC3 |
TCEB2 |
0.95 |
TCEB1 |
PSMA2 |
0.949 |
HIF3A |
EGLN3 |
0.949 |
UBXN7 |
RBX1 |
0.949 |
TCEB1 |
HIF1A |
0.949 |
HIF1A |
TCEB2 |
0.949 |
PSMD1 |
TCEB2 |
0.948 |
CUL2 |
HIF1A |
0.948 |
PSMD12 |
PSMD5 |
0.948 |
PSMD1 |
PSMD5 |
0.947 |
EGLN2 |
HIF3A |
0.947 |
CUL2 |
EGLN3 |
0.946 |
HIF1A |
CREBBP |
0.945 |
SMAD4 |
CREBBP |
0.944 |
CA9 |
HIF3A |
0.944 |
HIF3A |
EGLN1 |
0.944 |
HIF3A |
VHL |
0.943 |
TCEB2 |
EGLN3 |
0.943 |
CITED2 |
HIF1A |
0.943 |
EPAS1 |
TCEB2 |
0.943 |
CA9 |
ARNT |
0.943 |
PSMD2 |
PSMD5 |
0.943 |
CREBBP |
SMAD2 |
0.942 |
PSMC3 |
TCEB1 |
0.942 |
KLF4 |
EP300 |
0.942 |
SMAD4 |
SOX2 |
0.942 |
TCEB1 |
EPAS1 |
0.942 |
POLR2A |
TCEB1 |
0.941 |
POLR2A |
EP300 |
0.941 |
PSMB6 |
RBX1 |
0.941 |
SMAD4 |
POU5F1 |
0.941 |
PSMD2 |
TCEB2 |
0.94 |
HIF1A |
ARNT |
0.94 |
PSMB6 |
PSMD5 |
0.939 |
SMAD4 |
NANOG |
0.939 |
EP300 |
EPO |
0.939 |
PSMB4 |
RBX1 |
0.939 |
TCEB1 |
PSMD7 |
0.938 |
HIF1AN |
EPAS1 |
0.938 |
POLR2A |
RBX1 |
0.937 |
PSMB4 |
PSMD5 |
0.937 |
ARNT |
CREBBP |
0.936 |
EPAS1 |
SIRT1 |
0.936 |
ARNT |
EPAS1 |
0.936 |
UBB |
PSMB4 |
0.935 |
UBE2D3 |
UBB |
0.935 |
PSMC6 |
VHL |
0.935 |
KLF4 |
SMAD4 |
0.935 |
CUL2 |
EPAS1 |
0.935 |
TCEB1 |
UBE2D3 |
0.934 |
HIF1A |
PSMC6 |
0.934 |
PSMC3 |
CUL2 |
0.934 |
EPAS1 |
EP300 |
0.934 |
PSMC3 |
UBB |
0.933 |
HIF1A |
SMAD4 |
0.933 |
TCEB1 |
PSMC6 |
0.932 |
PSMC3 |
EGLN3 |
0.932 |
TCEB2 |
PSMA2 |
0.932 |
TCEB1 |
PSMD1 |
0.932 |
PSMB6 |
TCEB2 |
0.931 |
PRDM14 |
SALL4 |
0.931 |
KLF4 |
SALL4 |
0.931 |
PSMC3 |
EPAS1 |
0.931 |
TCEB1 |
PSMD12 |
0.931 |
PSMC3 |
HIF1A |
0.931 |
VEGFA |
CREBBP |
0.93 |
CA9 |
EP300 |
0.93 |
EGLN1 |
LIMD1 |
0.93 |
TCEB2 |
PSMD7 |
0.93 |
VEGFA |
HIF3A |
0.929 |
HIF1A |
NR3C1 |
0.929 |
PSMD12 |
TCEB2 |
0.929 |
EPAS1 |
POU5F1 |
0.929 |
PSMC3 |
EGLN1 |
0.928 |
CREBBP |
EPO |
0.928 |
POLR2A |
UBC |
0.928 |
EP300 |
RBX1 |
0.928 |
CREBBP |
RBX1 |
0.928 |
PSMC6 |
PSMD5 |
0.928 |
CITED2 |
EPAS1 |
0.928 |
EGLN1 |
RBX1 |
0.928 |
TCEB1 |
PSMD2 |
0.928 |
POLR2A |
CREBBP |
0.928 |
HIF1A |
RBX1 |
0.927 |
KLF4 |
PRDM14 |
0.926 |
HIF3A |
ARNT |
0.926 |
UBE2D3 |
UBXN7 |
0.926 |
TCEB1 |
PSMB4 |
0.926 |
PSMC3 |
UBC |
0.926 |
HIF3A |
EPO |
0.926 |
CUL2 |
UBE2D3 |
0.925 |
UBC |
RBX1 |
0.925 |
LIN28A |
SMAD2 |
0.925 |
TCEB1 |
PSMC2 |
0.925 |
SMAD4 |
NR3C1 |
0.924 |
KLF4 |
EPAS1 |
0.924 |
UBC |
PSMD12 |
0.924 |
PSMD7 |
RBX1 |
0.924 |
EPAS1 |
RBX1 |
0.923 |
HIF3A |
TCEB2 |
0.923 |
PSMD1 |
UBB |
0.923 |
SOX2 |
EPAS1 |
0.923 |
EPAS1 |
SALL4 |
0.922 |
PSMB4 |
TCEB2 |
0.922 |
PSMC6 |
RBX1 |
0.921 |
LIMD1 |
EGLN3 |
0.921 |
UBC |
PSMD2 |
0.921 |
EPAS1 |
NANOG |
0.921 |
UBB |
SMAD2 |
0.92 |
UBB |
RBX1 |
0.92 |
UBB |
PSMB6 |
0.92 |
TCEB1 |
PSMB6 |
0.92 |
UBC |
PSMB6 |
0.919 |
EGLN3 |
RBX1 |
0.919 |
LIN28A |
SMAD4 |
0.919 |
PSMD2 |
UBB |
0.919 |
EPAS1 |
CREBBP |
0.919 |
LIMD1 |
VHL |
0.918 |
SMAD4 |
SMAD2 |
0.918 |
SMAD2 |
SALL4 |
0.918 |
VEGFA |
EPO |
0.918 |
UBC |
PSMB4 |
0.918 |
ARNT |
SIRT1 |
0.918 |
SMAD4 |
SALL4 |
0.917 |
TCEB1 |
UBC |
0.917 |
UBC |
PSMD7 |
0.917 |
EPAS1 |
NR3C1 |
0.917 |
POLR2A |
EPAS1 |
0.916 |
CUL2 |
UBC |
0.916 |
POLR2A |
NR3C1 |
0.916 |
UBC |
HIF1A |
0.916 |
UBB |
EP300 |
0.916 |
PSMC2 |
PSMD5 |
0.916 |
TCEB1 |
HIF3A |
0.916 |
UBE2D3 |
TCEB2 |
0.915 |
PSMD12 |
UBB |
0.915 |
POLR2A |
TCEB2 |
0.915 |
UBC |
PSMC2 |
0.915 |
HIF3A |
EP300 |
0.915 |
PSMC2 |
TCEB2 |
0.915 |
TCEB1 |
UBB |
0.915 |
UBXN7 |
TCEB2 |
0.914 |
UBC |
EP300 |
0.914 |
CA9 |
CREBBP |
0.914 |
UBC |
PSMD1 |
0.914 |
CUL2 |
HIF3A |
0.914 |
SMAD4 |
EPAS1 |
0.913 |
CUL2 |
PSMD12 |
0.913 |
HIF1A |
HIGD1A |
0.913 |
UBC |
SMAD2 |
0.913 |
CITED2 |
HIF3A |
0.913 |
PSMC3 |
RBX1 |
0.913 |
PSMD12 |
RBX1 |
0.912 |
PSMC6 |
TCEB2 |
0.912 |
CUL2 |
PSMC2 |
0.912 |
CUL2 |
PSMD7 |
0.912 |
HIF1A |
UBXN7 |
0.912 |
PSMC3 |
PSMD5 |
0.912 |
UBB |
PSMD7 |
0.912 |
UBC |
UBXN7 |
0.911 |
UBB |
UBXN7 |
0.911 |
CUL2 |
PSMC6 |
0.911 |
EGLN1 |
UBB |
0.911 |
PRDM14 |
SMAD2 |
0.911 |
LIMD1 |
EPAS1 |
0.911 |
PTK6 |
HIF1A |
0.911 |
CITED2 |
ARNT |
0.91 |
CUL2 |
UBB |
0.91 |
UBB |
TCEB2 |
0.91 |
PSMD2 |
EPAS1 |
0.91 |
UBC |
PSMD5 |
0.91 |
UBE2D3 |
SMAD4 |
0.909 |
POLR2A |
NANOG |
0.909 |
UBC |
PSMC6 |
0.909 |
HIF3A |
RBX1 |
0.909 |
PSMC2 |
RBX1 |
0.909 |
UBC |
VHL |
0.909 |
POLR2A |
SOX2 |
0.908 |
UBC |
PSMA2 |
0.908 |
POLR2A |
UBB |
0.908 |
UBB |
EGLN3 |
0.908 |
EGLN1 |
PSMD2 |
0.908 |
UBC |
TCEB2 |
0.908 |
CUL2 |
PSMD2 |
0.908 |
UBC |
EGLN1 |
0.908 |
HIF3A |
EPAS1 |
0.908 |
CUL2 |
PSMD1 |
0.907 |
HIGD1A |
EPAS1 |
0.907 |
HIF1A |
PSMD2 |
0.907 |
PSMD1 |
EPAS1 |
0.907 |
PSMD1 |
RBX1 |
0.907 |
WTIP |
HIF3A |
0.907 |
TCEB2 |
PSMD5 |
0.907 |
HIF1A |
UBE2D3 |
0.907 |
PSMC2 |
UBB |
0.907 |
HIF1A |
EPAS1 |
0.907 |
UBE2D3 |
SMAD2 |
0.907 |
EGLN2 |
EGLN1 |
0.907 |
HIF1A |
LIMD1 |
0.907 |
HIF3A |
CREBBP |
0.907 |
PSMD2 |
RBX1 |
0.907 |
RBX1 |
PSMD5 |
0.907 |
WTIP |
HIF1A |
0.906 |
UBB |
VHL |
0.906 |
EPAS1 |
SMAD2 |
0.906 |
HIF1A |
PSMD5 |
0.906 |
PSMC6 |
UBB |
0.906 |
HIF1A |
PSMD1 |
0.906 |
ARNT |
APEX1 |
0.906 |
HIF1A |
HIF3A |
0.906 |
PTK6 |
EPAS1 |
0.905 |
UBC |
SMAD4 |
0.905 |
UBC |
EPAS1 |
0.905 |
TCEB1 |
PSMD5 |
0.905 |
PRDM14 |
EPAS1 |
0.905 |
HIF1A |
PSMD12 |
0.905 |
CUL2 |
PSMA2 |
0.905 |
UBE2D3 |
EPAS1 |
0.905 |
EGLN2 |
EGLN3 |
0.905 |
PSMA2 |
PSMD5 |
0.905 |
SMAD4 |
PRDM14 |
0.905 |
HIF1A |
PSMB6 |
0.905 |
EGLN1 |
EGLN3 |
0.905 |
WTIP |
LIMD1 |
0.905 |
HIF3A |
LIMD1 |
0.905 |
UBE2D3 |
VHL |
0.905 |
HIF1A |
PSMB4 |
0.904 |
WTIP |
EPAS1 |
0.904 |
UBC |
EGLN3 |
0.904 |
CUL2 |
LIMD1 |
0.904 |
UBB |
PSMD5 |
0.904 |
HIF1A |
PSMC2 |
0.904 |
PSMD12 |
VHL |
0.904 |
PTK6 |
NR3C1 |
0.904 |
CUL2 |
PSMB4 |
0.903 |
LIMD1 |
TCEB2 |
0.903 |
LIMD1 |
RBX1 |
0.903 |
HIF3A |
PSMD1 |
0.903 |
LIN28A |
EPAS1 |
0.903 |
HIF1A |
PSMD7 |
0.903 |
EPAS1 |
PSMD5 |
0.903 |
UBE2D3 |
EGLN3 |
0.903 |
UBXN7 |
EPAS1 |
0.903 |
UBB |
PSMA2 |
0.903 |
PSMB4 |
EPAS1 |
0.903 |
PSMD2 |
VHL |
0.903 |
PSMC2 |
EPAS1 |
0.903 |
PSMC6 |
EGLN1 |
0.903 |
HIF1A |
UBB |
0.903 |
HIF1A |
PSMA2 |
0.903 |
UBC |
HIF3A |
0.903 |
PSMD12 |
EPAS1 |
0.903 |
TCEB1 |
LIMD1 |
0.903 |
PSMC6 |
EPAS1 |
0.903 |
UBXN7 |
VHL |
0.903 |
EPAS1 |
APEX1 |
0.903 |
UBB |
EPAS1 |
0.902 |
EPAS1 |
PSMA2 |
0.902 |
WTIP |
PSMD1 |
0.902 |
HIF3A |
UBB |
0.902 |
PSMD2 |
LIMD1 |
0.902 |
PSMD2 |
EGLN3 |
0.902 |
HIGD1A |
ARNT |
0.902 |
WTIP |
PSMD2 |
0.902 |
PSMB6 |
EGLN3 |
0.902 |
WTIP |
TCEB2 |
0.902 |
CUL2 |
PSMD5 |
0.902 |
PSMB6 |
EPAS1 |
0.902 |
PSMD1 |
LIMD1 |
0.902 |
ARNT |
SMAD4 |
0.902 |
EPAS1 |
PSMD7 |
0.902 |
PSMC2 |
HIF3A |
0.901 |
VHL |
PSMA2 |
0.901 |
HIF3A |
PSMD2 |
0.901 |
HIF3A |
PSMD7 |
0.901 |
HIF3A |
UBE2D3 |
0.901 |
HIF3A |
UBXN7 |
0.901 |
PSMC6 |
EGLN3 |
0.901 |
HIF3A |
PSMD12 |
0.901 |
WTIP |
PSMA2 |
0.901 |
CUL2 |
PSMB6 |
0.901 |
HIF3A |
PSMB4 |
0.901 |
LIMD1 |
PSMA2 |
0.901 |
PSMC6 |
LIMD1 |
0.901 |
EGLN1 |
UBE2D3 |
0.901 |
WTIP |
PSMC6 |
0.901 |
WTIP |
UBB |
0.9 |
PSMD12 |
LIMD1 |
0.9 |
PSMC2 |
VHL |
0.9 |
PSMB4 |
LIMD1 |
0.9 |
PSMC3 |
WTIP |
0.9 |
WTIP |
PSMD12 |
0.9 |
PSMC2 |
EGLN3 |
0.9 |
WTIP |
EGLN1 |
0.9 |
PTK6 |
UBB |
0.9 |
UBC |
LIMD1 |
0.9 |
EGLN1 |
PSMD1 |
0.9 |
LIMD1 |
PSMD7 |
0.9 |
WTIP |
UBE2D3 |
0.9 |
PSMC6 |
HIF3A |
0.9 |
WTIP |
UBC |
0.9 |
HIF3A |
PSMA2 |
0.9 |
PSMB4 |
EGLN3 |
0.9 |
EGLN1 |
PSMB4 |
0.9 |
WTIP |
VHL |
0.9 |
EGLN3 |
PSMD5 |
0.9 |
WTIP |
CUL2 |
0.9 |
SMAD4 |
UBB |
0.9 |
EGLN3 |
PSMA2 |
0.9 |
LIMD1 |
PSMB6 |
0.9 |
PSMD12 |
EGLN3 |
0.9 |
PSMD1 |
EGLN3 |
0.9 |
VHL |
PSMD5 |
0.9 |
WTIP |
PSMB6 |
0.9 |
WTIP |
RBX1 |
0.9 |
LIMD1 |
PSMD5 |
0.9 |
PSMB6 |
VHL |
0.9 |
PSMC2 |
EGLN1 |
0.9 |
WTIP |
EGLN3 |
0.9 |
UBE2D3 |
LIMD1 |
0.9 |
PSMC3 |
HIF3A |
0.9 |
VHL |
PSMD7 |
0.9 |
PSMC2 |
LIMD1 |
0.9 |
WTIP |
PSMB4 |
0.9 |
PSMD1 |
VHL |
0.9 |
WTIP |
PSMD7 |
0.9 |
PSMC3 |
LIMD1 |
0.9 |
PSMB4 |
VHL |
0.9 |
POLR2A |
SALL4 |
0.9 |
HIF3A |
PSMD5 |
0.9 |
WTIP |
PSMC2 |
0.9 |
EGLN3 |
PSMD7 |
0.9 |
EGLN1 |
PSMD5 |
0.9 |
EGLN1 |
PSMD12 |
0.9 |
TCEB1 |
WTIP |
0.9 |
PTK6 |
UBC |
0.9 |
WTIP |
PSMD5 |
0.9 |
EGLN1 |
PSMD7 |
0.9 |
UBB |
LIMD1 |
0.9 |
EGLN1 |
PSMB6 |
0.9 |
HIGD1A |
HIF3A |
0.9 |
EGLN1 |
PSMA2 |
0.9 |
HIF3A |
PSMB6 |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
5702 (PSMC3) |
5707 (PSMD1) |
5708 (PSMD2) |
5706 (PSMC6) |
5701 (PSMC2) |
5692 (PSMB4) |
6657 (SOX2) |
6921 (TCEB1) |
5460 (POU5F1) |
5694 (PSMB6) |
79727 (LIN28A) |
9314 (KLF4) |
8453 (CUL2) |
7422 (VEGFA) |
6923 (TCEB2) |
3091 (HIF1A) |
5683 (PSMA2) |
79923 (NANOG) |
54583 (EGLN1) |
7316 (UBC) |
2033 (EP300) |
112398 (EGLN2) |
7428 (VHL) |
2034 (EPAS1) |
63978 (PRDM14) |
768 (CA9) |
10370 (CITED2) |
7323 (UBE2D3) |
5713 (PSMD7) |
405 (ARNT) |
4087 (SMAD2) |
4089 (SMAD4) |
1387 (CREBBP) |
64344 (HIF3A) |
26043 (UBXN7) |
5430 (POLR2A) |
55662 (HIF1AN) |
7314 (UBB) |
8994 (LIMD1) |
112399 (EGLN3) |
5753 (PTK6) |
126374 (WTIP) |
9978 (RBX1) |
57167 (SALL4) |
2056 (EPO) |
23411 (SIRT1) |
5711 (PSMD5) |
2908 (NR3C1) |
328 (APEX1) |
5702 (PSMC3)
|
1.00
|
0.66
|
0.67
|
0.96
|
0.92
|
0.67
|
0.44
|
0.64
|
0.45
|
0.49
|
0.47
|
0.43
|
0.62
|
0.64
|
0.71
|
0.59
|
0.67
|
0.42
|
0.50
|
0.62
|
0.42
|
0.51
|
0.62
|
0.61
|
0.49
|
0.63
|
0.57
|
0.56
|
0.74
|
0.52
|
0.50
|
0.47
|
0.47
|
0.21
|
0.72
|
0.53
|
0.52
|
0.65
|
0.57
|
0.55
|
0.65
|
0.63
|
0.53
|
0.63
|
0.62
|
0.58
|
1.00
|
0.42
|
0.33
|
5707 (PSMD1)
|
0.66
|
1.00
|
0.92
|
0.66
|
0.64
|
0.92
|
0.43
|
0.61
|
0.49
|
0.76
|
0.45
|
0.42
|
0.73
|
0.60
|
0.83
|
0.62
|
0.92
|
0.40
|
0.51
|
0.70
|
0.42
|
0.50
|
0.63
|
0.59
|
0.47
|
0.60
|
0.55
|
0.66
|
0.67
|
0.50
|
0.52
|
0.44
|
0.46
|
0.21
|
0.81
|
0.59
|
0.51
|
0.76
|
0.54
|
0.53
|
0.59
|
0.59
|
0.61
|
0.60
|
0.60
|
0.58
|
1.00
|
0.41
|
0.35
|
5708 (PSMD2)
|
0.67
|
0.92
|
1.00
|
0.67
|
0.64
|
1.00
|
0.41
|
0.62
|
0.42
|
0.85
|
0.43
|
0.40
|
0.59
|
0.60
|
0.69
|
0.58
|
1.00
|
0.38
|
0.48
|
0.60
|
0.42
|
0.48
|
0.61
|
0.59
|
0.45
|
0.60
|
0.55
|
0.54
|
0.69
|
0.49
|
0.48
|
0.43
|
0.45
|
0.21
|
0.71
|
0.51
|
0.50
|
0.63
|
0.53
|
0.52
|
0.59
|
0.59
|
0.53
|
0.59
|
0.60
|
0.57
|
1.00
|
0.40
|
0.34
|
5706 (PSMC6)
|
0.96
|
0.66
|
0.67
|
1.00
|
0.89
|
0.67
|
0.46
|
0.65
|
0.46
|
0.49
|
0.50
|
0.45
|
0.63
|
0.64
|
0.71
|
0.60
|
0.67
|
0.44
|
0.52
|
0.63
|
0.43
|
0.53
|
0.63
|
0.61
|
0.52
|
0.64
|
0.58
|
0.58
|
0.73
|
0.54
|
0.50
|
0.48
|
0.48
|
0.21
|
0.72
|
0.54
|
0.53
|
0.66
|
0.59
|
0.57
|
0.66
|
0.64
|
0.55
|
0.64
|
0.63
|
0.58
|
1.00
|
0.44
|
0.34
|
5701 (PSMC2)
|
0.92
|
0.64
|
0.64
|
0.89
|
1.00
|
0.64
|
0.43
|
0.61
|
0.44
|
0.47
|
0.46
|
0.42
|
0.60
|
0.61
|
0.68
|
0.60
|
0.64
|
0.41
|
0.49
|
0.61
|
0.43
|
0.49
|
0.63
|
0.61
|
0.48
|
0.60
|
0.56
|
0.54
|
0.69
|
0.52
|
0.50
|
0.44
|
0.47
|
0.21
|
0.73
|
0.51
|
0.50
|
0.63
|
0.55
|
0.53
|
0.59
|
0.60
|
0.54
|
0.61
|
0.61
|
0.57
|
1.00
|
0.41
|
0.32
|
5692 (PSMB4)
|
0.67
|
0.92
|
1.00
|
0.67
|
0.64
|
1.00
|
0.41
|
0.62
|
0.42
|
0.85
|
0.43
|
0.40
|
0.59
|
0.60
|
0.69
|
0.58
|
1.00
|
0.38
|
0.48
|
0.60
|
0.42
|
0.48
|
0.61
|
0.59
|
0.45
|
0.60
|
0.55
|
0.54
|
0.69
|
0.49
|
0.48
|
0.43
|
0.45
|
0.21
|
0.71
|
0.51
|
0.50
|
0.63
|
0.53
|
0.52
|
0.59
|
0.59
|
0.53
|
0.59
|
0.60
|
0.57
|
1.00
|
0.40
|
0.34
|
6657 (SOX2)
|
0.44
|
0.43
|
0.41
|
0.46
|
0.43
|
0.41
|
1.00
|
0.41
|
0.92
|
0.28
|
0.63
|
0.81
|
0.42
|
0.53
|
0.45
|
0.82
|
0.41
|
0.87
|
0.39
|
0.63
|
0.50
|
0.38
|
0.45
|
0.87
|
0.84
|
0.41
|
0.61
|
0.40
|
0.45
|
0.86
|
0.78
|
0.81
|
0.65
|
1.00
|
0.50
|
0.63
|
0.43
|
0.46
|
0.40
|
0.38
|
0.45
|
0.41
|
0.42
|
0.68
|
0.44
|
0.56
|
1.00
|
0.73
|
0.44
|
6921 (TCEB1)
|
0.64
|
0.61
|
0.62
|
0.65
|
0.61
|
0.62
|
0.41
|
1.00
|
0.42
|
0.46
|
0.44
|
0.40
|
0.83
|
0.60
|
0.70
|
0.58
|
0.62
|
0.38
|
0.50
|
0.61
|
0.47
|
0.49
|
0.91
|
0.59
|
0.45
|
0.62
|
0.55
|
0.90
|
0.70
|
0.49
|
0.48
|
0.43
|
0.49
|
0.21
|
0.72
|
0.56
|
0.51
|
0.64
|
0.54
|
0.54
|
0.65
|
0.59
|
0.84
|
0.60
|
0.60
|
0.54
|
1.00
|
0.40
|
0.31
|
5460 (POU5F1)
|
0.45
|
0.49
|
0.42
|
0.46
|
0.44
|
0.42
|
0.92
|
0.42
|
1.00
|
0.29
|
0.67
|
0.75
|
0.49
|
0.53
|
0.52
|
0.84
|
0.42
|
0.85
|
0.41
|
0.71
|
0.52
|
0.39
|
0.46
|
0.85
|
0.85
|
0.42
|
0.60
|
0.47
|
0.46
|
0.83
|
0.78
|
0.78
|
0.68
|
1.00
|
0.55
|
0.69
|
0.44
|
0.52
|
0.41
|
0.40
|
0.45
|
0.42
|
0.47
|
0.65
|
0.45
|
0.53
|
1.00
|
0.69
|
0.46
|
5694 (PSMB6)
|
0.49
|
0.76
|
0.85
|
0.49
|
0.47
|
0.85
|
0.28
|
0.46
|
0.29
|
1.00
|
0.30
|
0.28
|
0.43
|
0.41
|
0.48
|
0.40
|
0.85
|
0.27
|
0.36
|
0.42
|
0.30
|
0.35
|
0.45
|
0.40
|
0.32
|
0.45
|
0.38
|
0.41
|
0.49
|
0.34
|
0.33
|
0.29
|
0.32
|
0.15
|
0.49
|
0.36
|
0.36
|
0.44
|
0.37
|
0.39
|
0.42
|
0.42
|
0.39
|
0.42
|
0.42
|
0.42
|
0.69
|
0.28
|
0.28
|
79727 (LIN28A)
|
0.47
|
0.45
|
0.43
|
0.50
|
0.46
|
0.43
|
0.63
|
0.44
|
0.67
|
0.30
|
1.00
|
0.44
|
0.45
|
0.54
|
0.49
|
0.59
|
0.43
|
0.51
|
0.40
|
0.74
|
0.46
|
0.40
|
0.48
|
0.65
|
0.55
|
0.43
|
0.47
|
0.42
|
0.49
|
0.55
|
0.57
|
0.52
|
0.49
|
0.21
|
0.54
|
0.67
|
0.45
|
0.47
|
0.42
|
0.40
|
0.47
|
0.44
|
0.44
|
0.44
|
0.47
|
0.49
|
1.00
|
0.42
|
0.42
|
9314 (KLF4)
|
0.43
|
0.42
|
0.40
|
0.45
|
0.42
|
0.40
|
0.81
|
0.40
|
0.75
|
0.28
|
0.44
|
1.00
|
0.41
|
0.52
|
0.44
|
0.75
|
0.40
|
0.79
|
0.43
|
0.50
|
0.51
|
0.43
|
0.45
|
0.73
|
0.72
|
0.40
|
0.67
|
0.40
|
0.44
|
0.77
|
0.73
|
0.77
|
0.71
|
1.00
|
0.50
|
0.55
|
0.51
|
0.45
|
0.54
|
0.38
|
0.44
|
0.44
|
0.43
|
0.65
|
0.43
|
0.56
|
1.00
|
0.73
|
0.39
|
8453 (CUL2)
|
0.62
|
0.73
|
0.59
|
0.63
|
0.60
|
0.59
|
0.42
|
0.83
|
0.49
|
0.43
|
0.45
|
0.41
|
1.00
|
0.60
|
0.83
|
0.62
|
0.59
|
0.40
|
0.50
|
0.70
|
0.45
|
0.49
|
0.89
|
0.59
|
0.47
|
0.59
|
0.55
|
0.88
|
0.67
|
0.50
|
0.52
|
0.43
|
0.48
|
0.21
|
0.81
|
0.61
|
0.50
|
0.75
|
0.54
|
0.52
|
0.62
|
0.59
|
0.89
|
0.59
|
0.60
|
0.53
|
1.00
|
0.41
|
0.30
|
7422 (VEGFA)
|
0.64
|
0.60
|
0.60
|
0.64
|
0.61
|
0.60
|
0.53
|
0.60
|
0.53
|
0.41
|
0.54
|
0.52
|
0.60
|
1.00
|
0.62
|
0.62
|
0.60
|
0.52
|
0.56
|
0.61
|
0.48
|
0.56
|
0.60
|
0.63
|
0.56
|
0.60
|
0.59
|
0.58
|
0.67
|
0.61
|
0.55
|
0.57
|
0.53
|
0.28
|
0.64
|
0.56
|
0.59
|
0.62
|
0.59
|
0.58
|
0.67
|
0.60
|
0.57
|
0.61
|
0.66
|
0.58
|
1.00
|
0.51
|
0.41
|
6923 (TCEB2)
|
0.71
|
0.83
|
0.69
|
0.71
|
0.68
|
0.69
|
0.45
|
0.70
|
0.52
|
0.48
|
0.49
|
0.44
|
0.83
|
0.62
|
1.00
|
0.65
|
0.69
|
0.43
|
0.53
|
0.77
|
0.42
|
0.52
|
0.67
|
0.63
|
0.52
|
0.69
|
0.59
|
0.72
|
0.80
|
0.53
|
0.53
|
0.45
|
0.47
|
0.21
|
0.92
|
0.62
|
0.52
|
0.87
|
0.62
|
0.58
|
0.64
|
0.70
|
0.63
|
0.70
|
0.67
|
0.54
|
1.00
|
0.43
|
0.29
|
3091 (HIF1A)
|
0.59
|
0.62
|
0.58
|
0.60
|
0.60
|
0.58
|
0.82
|
0.58
|
0.84
|
0.40
|
0.59
|
0.75
|
0.62
|
0.62
|
0.65
|
1.00
|
0.58
|
0.80
|
0.57
|
0.67
|
0.56
|
0.54
|
0.64
|
0.89
|
0.80
|
0.58
|
0.74
|
0.60
|
0.61
|
0.86
|
0.77
|
0.74
|
0.70
|
1.00
|
0.68
|
0.64
|
0.55
|
0.65
|
0.57
|
0.56
|
0.59
|
0.58
|
0.60
|
0.78
|
0.59
|
0.69
|
1.00
|
0.76
|
0.46
|
5683 (PSMA2)
|
0.67
|
0.92
|
1.00
|
0.67
|
0.64
|
1.00
|
0.41
|
0.62
|
0.42
|
0.85
|
0.43
|
0.40
|
0.59
|
0.60
|
0.69
|
0.58
|
1.00
|
0.38
|
0.48
|
0.60
|
0.42
|
0.48
|
0.61
|
0.59
|
0.45
|
0.60
|
0.55
|
0.54
|
0.69
|
0.49
|
0.48
|
0.43
|
0.45
|
0.21
|
0.71
|
0.51
|
0.50
|
0.63
|
0.53
|
0.52
|
0.59
|
0.59
|
0.53
|
0.59
|
0.60
|
0.57
|
1.00
|
0.40
|
0.34
|
79923 (NANOG)
|
0.42
|
0.40
|
0.38
|
0.44
|
0.41
|
0.38
|
0.87
|
0.38
|
0.85
|
0.27
|
0.51
|
0.79
|
0.40
|
0.52
|
0.43
|
0.80
|
0.38
|
1.00
|
0.37
|
0.55
|
0.52
|
0.36
|
0.43
|
0.81
|
0.84
|
0.38
|
0.73
|
0.38
|
0.43
|
0.82
|
0.76
|
0.83
|
0.69
|
1.00
|
0.48
|
0.56
|
0.42
|
0.44
|
0.53
|
0.36
|
0.43
|
0.55
|
0.41
|
0.67
|
0.42
|
0.59
|
1.00
|
0.73
|
0.47
|
54583 (EGLN1)
|
0.50
|
0.51
|
0.48
|
0.52
|
0.49
|
0.48
|
0.39
|
0.50
|
0.41
|
0.36
|
0.40
|
0.43
|
0.50
|
0.56
|
0.53
|
0.57
|
0.48
|
0.37
|
1.00
|
0.54
|
0.42
|
0.93
|
0.56
|
0.53
|
0.41
|
0.48
|
0.50
|
0.49
|
0.52
|
0.46
|
0.48
|
0.41
|
0.44
|
0.21
|
0.58
|
0.47
|
0.78
|
0.53
|
0.53
|
0.89
|
0.50
|
0.47
|
0.50
|
0.47
|
0.50
|
0.53
|
1.00
|
0.39
|
0.38
|
7316 (UBC)
|
0.62
|
0.70
|
0.60
|
0.63
|
0.61
|
0.60
|
0.63
|
0.61
|
0.71
|
0.42
|
0.74
|
0.50
|
0.70
|
0.61
|
0.77
|
0.67
|
0.60
|
0.55
|
0.54
|
1.00
|
0.48
|
0.51
|
0.64
|
0.69
|
0.61
|
0.60
|
0.58
|
0.65
|
0.66
|
0.60
|
0.62
|
0.55
|
0.53
|
0.28
|
0.77
|
0.72
|
0.52
|
0.88
|
0.57
|
0.55
|
0.60
|
0.61
|
0.60
|
0.61
|
0.61
|
0.55
|
1.00
|
0.48
|
0.42
|
2033 (EP300)
|
0.42
|
0.42
|
0.42
|
0.43
|
0.43
|
0.42
|
0.50
|
0.47
|
0.52
|
0.30
|
0.46
|
0.51
|
0.45
|
0.48
|
0.42
|
0.56
|
0.42
|
0.52
|
0.42
|
0.48
|
1.00
|
0.41
|
0.51
|
0.55
|
0.51
|
0.42
|
0.53
|
0.47
|
0.42
|
0.52
|
0.56
|
0.56
|
0.79
|
0.21
|
0.47
|
0.57
|
0.44
|
0.43
|
0.44
|
0.41
|
0.47
|
0.45
|
0.52
|
0.41
|
0.42
|
0.55
|
1.00
|
0.46
|
0.51
|
112398 (EGLN2)
|
0.51
|
0.50
|
0.48
|
0.53
|
0.49
|
0.48
|
0.38
|
0.49
|
0.39
|
0.35
|
0.40
|
0.43
|
0.49
|
0.56
|
0.52
|
0.54
|
0.48
|
0.36
|
0.93
|
0.51
|
0.41
|
1.00
|
0.53
|
0.51
|
0.41
|
0.48
|
0.49
|
0.47
|
0.52
|
0.46
|
0.46
|
0.41
|
0.43
|
0.21
|
0.57
|
0.46
|
0.81
|
0.51
|
0.53
|
0.85
|
0.50
|
0.46
|
0.48
|
0.47
|
0.50
|
0.51
|
1.00
|
0.38
|
0.36
|
7428 (VHL)
|
0.62
|
0.63
|
0.61
|
0.63
|
0.63
|
0.61
|
0.45
|
0.91
|
0.46
|
0.45
|
0.48
|
0.45
|
0.89
|
0.60
|
0.67
|
0.64
|
0.61
|
0.43
|
0.56
|
0.64
|
0.51
|
0.53
|
1.00
|
0.63
|
0.50
|
0.61
|
0.57
|
0.88
|
0.65
|
0.54
|
0.53
|
0.45
|
0.55
|
0.21
|
0.73
|
0.58
|
0.54
|
0.64
|
0.56
|
0.56
|
0.65
|
0.59
|
0.92
|
0.60
|
0.60
|
0.59
|
1.00
|
0.44
|
0.35
|
2034 (EPAS1)
|
0.61
|
0.59
|
0.59
|
0.61
|
0.61
|
0.59
|
0.87
|
0.59
|
0.85
|
0.40
|
0.65
|
0.73
|
0.59
|
0.63
|
0.63
|
0.89
|
0.59
|
0.81
|
0.53
|
0.69
|
0.55
|
0.51
|
0.63
|
1.00
|
0.86
|
0.59
|
0.68
|
0.55
|
0.64
|
0.89
|
0.74
|
0.74
|
0.67
|
1.00
|
0.69
|
0.68
|
0.52
|
0.61
|
0.56
|
0.54
|
0.58
|
0.59
|
0.56
|
0.77
|
0.59
|
0.59
|
1.00
|
0.67
|
0.45
|
63978 (PRDM14)
|
0.49
|
0.47
|
0.45
|
0.52
|
0.48
|
0.45
|
0.84
|
0.45
|
0.85
|
0.32
|
0.55
|
0.72
|
0.47
|
0.56
|
0.52
|
0.80
|
0.45
|
0.84
|
0.41
|
0.61
|
0.51
|
0.41
|
0.50
|
0.86
|
1.00
|
0.45
|
0.61
|
0.44
|
0.52
|
0.81
|
0.72
|
0.75
|
0.63
|
1.00
|
0.57
|
0.61
|
0.45
|
0.50
|
0.44
|
0.41
|
0.49
|
0.45
|
0.45
|
0.68
|
0.49
|
0.53
|
1.00
|
0.67
|
0.42
|
768 (CA9)
|
0.63
|
0.60
|
0.60
|
0.64
|
0.60
|
0.60
|
0.41
|
0.62
|
0.42
|
0.45
|
0.43
|
0.40
|
0.59
|
0.60
|
0.69
|
0.58
|
0.60
|
0.38
|
0.48
|
0.60
|
0.42
|
0.48
|
0.61
|
0.59
|
0.45
|
1.00
|
0.55
|
0.54
|
0.69
|
0.49
|
0.48
|
0.43
|
0.45
|
0.21
|
0.71
|
0.51
|
0.50
|
0.63
|
0.53
|
0.52
|
0.59
|
0.59
|
0.53
|
0.59
|
0.60
|
0.53
|
1.00
|
0.40
|
0.31
|
10370 (CITED2)
|
0.57
|
0.55
|
0.55
|
0.58
|
0.56
|
0.55
|
0.61
|
0.55
|
0.60
|
0.38
|
0.47
|
0.67
|
0.55
|
0.59
|
0.59
|
0.74
|
0.55
|
0.73
|
0.50
|
0.58
|
0.53
|
0.49
|
0.57
|
0.68
|
0.61
|
0.55
|
1.00
|
0.52
|
0.59
|
0.64
|
0.59
|
0.63
|
0.69
|
0.82
|
0.62
|
0.56
|
0.51
|
0.58
|
0.72
|
0.51
|
0.55
|
0.76
|
0.51
|
0.67
|
0.56
|
0.64
|
1.00
|
0.58
|
0.45
|
7323 (UBE2D3)
|
0.56
|
0.66
|
0.54
|
0.58
|
0.54
|
0.54
|
0.40
|
0.90
|
0.47
|
0.41
|
0.42
|
0.40
|
0.88
|
0.58
|
0.72
|
0.60
|
0.54
|
0.38
|
0.49
|
0.65
|
0.47
|
0.47
|
0.88
|
0.55
|
0.44
|
0.54
|
0.52
|
1.00
|
0.59
|
0.48
|
0.51
|
0.42
|
0.49
|
0.21
|
0.73
|
0.60
|
0.50
|
0.68
|
0.49
|
0.50
|
0.60
|
0.52
|
0.88
|
0.52
|
0.54
|
0.54
|
1.00
|
0.40
|
0.32
|
5713 (PSMD7)
|
0.74
|
0.67
|
0.69
|
0.73
|
0.69
|
0.69
|
0.45
|
0.70
|
0.46
|
0.49
|
0.49
|
0.44
|
0.67
|
0.67
|
0.80
|
0.61
|
0.69
|
0.43
|
0.52
|
0.66
|
0.42
|
0.52
|
0.65
|
0.64
|
0.52
|
0.69
|
0.59
|
0.59
|
1.00
|
0.59
|
0.50
|
0.49
|
0.47
|
0.21
|
0.79
|
0.54
|
0.57
|
0.71
|
0.62
|
0.58
|
0.66
|
0.70
|
0.55
|
0.71
|
0.67
|
0.54
|
1.00
|
0.43
|
0.29
|
405 (ARNT)
|
0.52
|
0.50
|
0.49
|
0.54
|
0.52
|
0.49
|
0.86
|
0.49
|
0.83
|
0.34
|
0.55
|
0.77
|
0.50
|
0.61
|
0.53
|
0.86
|
0.49
|
0.82
|
0.46
|
0.60
|
0.52
|
0.46
|
0.54
|
0.89
|
0.81
|
0.49
|
0.64
|
0.48
|
0.59
|
1.00
|
0.76
|
0.79
|
0.68
|
1.00
|
0.59
|
0.59
|
0.52
|
0.53
|
0.48
|
0.47
|
0.52
|
0.49
|
0.51
|
0.71
|
0.51
|
0.57
|
1.00
|
0.70
|
0.43
|
4087 (SMAD2)
|
0.50
|
0.52
|
0.48
|
0.50
|
0.50
|
0.48
|
0.78
|
0.48
|
0.78
|
0.33
|
0.57
|
0.73
|
0.52
|
0.55
|
0.53
|
0.77
|
0.48
|
0.76
|
0.48
|
0.62
|
0.56
|
0.46
|
0.53
|
0.74
|
0.72
|
0.48
|
0.59
|
0.51
|
0.50
|
0.76
|
1.00
|
0.81
|
0.67
|
1.00
|
0.57
|
0.62
|
0.48
|
0.54
|
0.48
|
0.47
|
0.50
|
0.48
|
0.52
|
0.62
|
0.51
|
0.58
|
1.00
|
0.71
|
0.48
|
4089 (SMAD4)
|
0.47
|
0.44
|
0.43
|
0.48
|
0.44
|
0.43
|
0.81
|
0.43
|
0.78
|
0.29
|
0.52
|
0.77
|
0.43
|
0.57
|
0.45
|
0.74
|
0.43
|
0.83
|
0.41
|
0.55
|
0.56
|
0.41
|
0.45
|
0.74
|
0.75
|
0.43
|
0.63
|
0.42
|
0.49
|
0.79
|
0.81
|
1.00
|
0.69
|
1.00
|
0.48
|
0.57
|
0.48
|
0.46
|
0.49
|
0.41
|
0.47
|
0.50
|
0.43
|
0.58
|
0.45
|
0.58
|
1.00
|
0.73
|
0.49
|
1387 (CREBBP)
|
0.47
|
0.46
|
0.45
|
0.48
|
0.47
|
0.45
|
0.65
|
0.49
|
0.68
|
0.32
|
0.49
|
0.71
|
0.48
|
0.53
|
0.47
|
0.70
|
0.45
|
0.69
|
0.44
|
0.53
|
0.79
|
0.43
|
0.55
|
0.67
|
0.63
|
0.45
|
0.69
|
0.49
|
0.47
|
0.68
|
0.67
|
0.69
|
1.00
|
0.82
|
0.54
|
0.58
|
0.47
|
0.48
|
0.50
|
0.44
|
0.49
|
0.51
|
0.54
|
0.55
|
0.47
|
0.59
|
1.00
|
0.59
|
0.49
|
64344 (HIF3A)
|
0.21
|
0.21
|
0.21
|
0.21
|
0.21
|
0.21
|
1.00
|
0.21
|
1.00
|
0.15
|
0.21
|
1.00
|
0.21
|
0.28
|
0.21
|
1.00
|
0.21
|
1.00
|
0.21
|
0.28
|
0.21
|
0.21
|
0.21
|
1.00
|
1.00
|
0.21
|
0.82
|
0.21
|
0.21
|
1.00
|
1.00
|
1.00
|
0.82
|
1.00
|
0.21
|
0.21
|
0.21
|
0.28
|
0.21
|
0.21
|
0.21
|
0.21
|
0.21
|
1.00
|
0.21
|
0.65
|
0.21
|
1.00
|
0.21
|
26043 (UBXN7)
|
0.72
|
0.81
|
0.71
|
0.72
|
0.73
|
0.71
|
0.50
|
0.72
|
0.55
|
0.49
|
0.54
|
0.50
|
0.81
|
0.64
|
0.92
|
0.68
|
0.71
|
0.48
|
0.58
|
0.77
|
0.47
|
0.57
|
0.73
|
0.69
|
0.57
|
0.71
|
0.62
|
0.73
|
0.79
|
0.59
|
0.57
|
0.48
|
0.54
|
0.21
|
1.00
|
0.64
|
0.56
|
0.84
|
0.66
|
0.63
|
0.67
|
0.72
|
0.68
|
0.72
|
0.69
|
0.58
|
1.00
|
0.46
|
0.32
|
5430 (POLR2A)
|
0.53
|
0.59
|
0.51
|
0.54
|
0.51
|
0.51
|
0.63
|
0.56
|
0.69
|
0.36
|
0.67
|
0.55
|
0.61
|
0.56
|
0.62
|
0.64
|
0.51
|
0.56
|
0.47
|
0.72
|
0.57
|
0.46
|
0.58
|
0.68
|
0.61
|
0.51
|
0.56
|
0.60
|
0.54
|
0.59
|
0.62
|
0.57
|
0.58
|
0.21
|
0.64
|
1.00
|
0.48
|
0.61
|
0.48
|
0.48
|
0.58
|
0.50
|
0.59
|
0.50
|
0.52
|
0.53
|
1.00
|
0.47
|
0.46
|
55662 (HIF1AN)
|
0.52
|
0.51
|
0.50
|
0.53
|
0.50
|
0.50
|
0.43
|
0.51
|
0.44
|
0.36
|
0.45
|
0.51
|
0.50
|
0.59
|
0.52
|
0.55
|
0.50
|
0.42
|
0.78
|
0.52
|
0.44
|
0.81
|
0.54
|
0.52
|
0.45
|
0.50
|
0.51
|
0.50
|
0.57
|
0.52
|
0.48
|
0.48
|
0.47
|
0.21
|
0.56
|
0.48
|
1.00
|
0.51
|
0.59
|
0.70
|
0.53
|
0.49
|
0.51
|
0.49
|
0.51
|
0.54
|
1.00
|
0.42
|
0.43
|
7314 (UBB)
|
0.65
|
0.76
|
0.63
|
0.66
|
0.63
|
0.63
|
0.46
|
0.64
|
0.52
|
0.44
|
0.47
|
0.45
|
0.75
|
0.62
|
0.87
|
0.65
|
0.63
|
0.44
|
0.53
|
0.88
|
0.43
|
0.51
|
0.64
|
0.61
|
0.50
|
0.63
|
0.58
|
0.68
|
0.71
|
0.53
|
0.54
|
0.46
|
0.48
|
0.28
|
0.84
|
0.61
|
0.51
|
1.00
|
0.58
|
0.55
|
0.61
|
0.64
|
0.62
|
0.64
|
0.63
|
0.55
|
1.00
|
0.44
|
0.31
|
8994 (LIMD1)
|
0.57
|
0.54
|
0.53
|
0.59
|
0.55
|
0.53
|
0.40
|
0.54
|
0.41
|
0.37
|
0.42
|
0.54
|
0.54
|
0.59
|
0.62
|
0.57
|
0.53
|
0.53
|
0.53
|
0.57
|
0.44
|
0.53
|
0.56
|
0.56
|
0.44
|
0.53
|
0.72
|
0.49
|
0.62
|
0.48
|
0.48
|
0.49
|
0.50
|
0.21
|
0.66
|
0.48
|
0.59
|
0.58
|
1.00
|
0.47
|
0.55
|
0.86
|
0.49
|
0.54
|
0.56
|
0.57
|
1.00
|
0.40
|
0.39
|
112399 (EGLN3)
|
0.55
|
0.53
|
0.52
|
0.57
|
0.53
|
0.52
|
0.38
|
0.54
|
0.40
|
0.39
|
0.40
|
0.38
|
0.52
|
0.58
|
0.58
|
0.56
|
0.52
|
0.36
|
0.89
|
0.55
|
0.41
|
0.85
|
0.56
|
0.54
|
0.41
|
0.52
|
0.51
|
0.50
|
0.58
|
0.47
|
0.47
|
0.41
|
0.44
|
0.21
|
0.63
|
0.48
|
0.70
|
0.55
|
0.47
|
1.00
|
0.53
|
0.49
|
0.50
|
0.50
|
0.53
|
0.52
|
1.00
|
0.38
|
0.33
|
5753 (PTK6)
|
0.65
|
0.59
|
0.59
|
0.66
|
0.59
|
0.59
|
0.45
|
0.65
|
0.45
|
0.42
|
0.47
|
0.44
|
0.62
|
0.67
|
0.64
|
0.59
|
0.59
|
0.43
|
0.50
|
0.60
|
0.47
|
0.50
|
0.65
|
0.58
|
0.49
|
0.59
|
0.55
|
0.60
|
0.66
|
0.52
|
0.50
|
0.47
|
0.49
|
0.21
|
0.67
|
0.58
|
0.53
|
0.61
|
0.55
|
0.53
|
1.00
|
0.58
|
0.58
|
0.58
|
0.62
|
0.55
|
1.00
|
0.43
|
0.32
|
126374 (WTIP)
|
0.63
|
0.59
|
0.59
|
0.64
|
0.60
|
0.59
|
0.41
|
0.59
|
0.42
|
0.42
|
0.44
|
0.44
|
0.59
|
0.60
|
0.70
|
0.58
|
0.59
|
0.55
|
0.47
|
0.61
|
0.45
|
0.46
|
0.59
|
0.59
|
0.45
|
0.59
|
0.76
|
0.52
|
0.70
|
0.49
|
0.48
|
0.50
|
0.51
|
0.21
|
0.72
|
0.50
|
0.49
|
0.64
|
0.86
|
0.49
|
0.58
|
1.00
|
0.50
|
0.60
|
0.60
|
0.59
|
1.00
|
0.40
|
0.36
|
9978 (RBX1)
|
0.53
|
0.61
|
0.53
|
0.55
|
0.54
|
0.53
|
0.42
|
0.84
|
0.47
|
0.39
|
0.44
|
0.43
|
0.89
|
0.57
|
0.63
|
0.60
|
0.53
|
0.41
|
0.50
|
0.60
|
0.52
|
0.48
|
0.92
|
0.56
|
0.45
|
0.53
|
0.51
|
0.88
|
0.55
|
0.51
|
0.52
|
0.43
|
0.54
|
0.21
|
0.68
|
0.59
|
0.51
|
0.62
|
0.49
|
0.50
|
0.58
|
0.50
|
1.00
|
0.51
|
0.52
|
0.56
|
1.00
|
0.41
|
0.36
|
57167 (SALL4)
|
0.63
|
0.60
|
0.59
|
0.64
|
0.61
|
0.59
|
0.68
|
0.60
|
0.65
|
0.42
|
0.44
|
0.65
|
0.59
|
0.61
|
0.70
|
0.78
|
0.59
|
0.67
|
0.47
|
0.61
|
0.41
|
0.47
|
0.60
|
0.77
|
0.68
|
0.59
|
0.67
|
0.52
|
0.71
|
0.71
|
0.62
|
0.58
|
0.55
|
1.00
|
0.72
|
0.50
|
0.49
|
0.64
|
0.54
|
0.50
|
0.58
|
0.60
|
0.51
|
1.00
|
0.61
|
0.56
|
1.00
|
0.62
|
0.27
|
2056 (EPO)
|
0.62
|
0.60
|
0.60
|
0.63
|
0.61
|
0.60
|
0.44
|
0.60
|
0.45
|
0.42
|
0.47
|
0.43
|
0.60
|
0.66
|
0.67
|
0.59
|
0.60
|
0.42
|
0.50
|
0.61
|
0.42
|
0.50
|
0.60
|
0.59
|
0.49
|
0.60
|
0.56
|
0.54
|
0.67
|
0.51
|
0.51
|
0.45
|
0.47
|
0.21
|
0.69
|
0.52
|
0.51
|
0.63
|
0.56
|
0.53
|
0.62
|
0.60
|
0.52
|
0.61
|
1.00
|
0.53
|
1.00
|
0.42
|
0.30
|
23411 (SIRT1)
|
0.58
|
0.58
|
0.57
|
0.58
|
0.57
|
0.57
|
0.56
|
0.54
|
0.53
|
0.42
|
0.49
|
0.56
|
0.53
|
0.58
|
0.54
|
0.69
|
0.57
|
0.59
|
0.53
|
0.55
|
0.55
|
0.51
|
0.59
|
0.59
|
0.53
|
0.53
|
0.64
|
0.54
|
0.54
|
0.57
|
0.58
|
0.58
|
0.59
|
0.65
|
0.58
|
0.53
|
0.54
|
0.55
|
0.57
|
0.52
|
0.55
|
0.59
|
0.56
|
0.56
|
0.53
|
1.00
|
1.00
|
0.56
|
0.52
|
5711 (PSMD5)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.69
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.21
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
2908 (NR3C1)
|
0.42
|
0.41
|
0.40
|
0.44
|
0.41
|
0.40
|
0.73
|
0.40
|
0.69
|
0.28
|
0.42
|
0.73
|
0.41
|
0.51
|
0.43
|
0.76
|
0.40
|
0.73
|
0.39
|
0.48
|
0.46
|
0.38
|
0.44
|
0.67
|
0.67
|
0.40
|
0.58
|
0.40
|
0.43
|
0.70
|
0.71
|
0.73
|
0.59
|
1.00
|
0.46
|
0.47
|
0.42
|
0.44
|
0.40
|
0.38
|
0.43
|
0.40
|
0.41
|
0.62
|
0.42
|
0.56
|
1.00
|
1.00
|
0.34
|
328 (APEX1)
|
0.33
|
0.35
|
0.34
|
0.34
|
0.32
|
0.34
|
0.44
|
0.31
|
0.46
|
0.28
|
0.42
|
0.39
|
0.30
|
0.41
|
0.29
|
0.46
|
0.34
|
0.47
|
0.38
|
0.42
|
0.51
|
0.36
|
0.35
|
0.45
|
0.42
|
0.31
|
0.45
|
0.32
|
0.29
|
0.43
|
0.48
|
0.49
|
0.49
|
0.21
|
0.32
|
0.46
|
0.43
|
0.31
|
0.39
|
0.33
|
0.32
|
0.36
|
0.36
|
0.27
|
0.30
|
0.52
|
1.00
|
0.34
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
EPAS1 |
Human |
Blood |
3-10% Oxygen |
5800 m |
2 hours |
upregulated |
- |
- |
- |
- |
- |
Soldier exposed to high altitude compared to their low altitude profile |
http://dx.doi.org/10.4172/jpb.S3-004 |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
2034 |
GO:0035019 |
somatic stem cell population maintenance |
GOTERM_BP_DIRECT |
2034 |
GO:0002027 |
regulation of heart rate |
GOTERM_BP_DIRECT |
2034 |
GO:0008134 |
transcription factor binding |
GOTERM_MF_DIRECT |
2034 |
GO:0005667 |
transcription factor complex |
GOTERM_CC_DIRECT |
2034 |
GO:0001892 |
embryonic placenta development |
GOTERM_BP_DIRECT |
2034 |
GO:0007165 |
signal transduction |
GOTERM_BP_DIRECT |
2034 |
GO:0042415 |
norepinephrine metabolic process |
GOTERM_BP_DIRECT |
2034 |
GO:0007005 |
mitochondrion organization |
GOTERM_BP_DIRECT |
2034 |
GO:0007601 |
visual perception |
GOTERM_BP_DIRECT |
2034 |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
GOTERM_BP_DIRECT |
2034 |
GO:0003677 |
DNA binding |
GOTERM_MF_DIRECT |
2034 |
GO:0005737 |
cytoplasm |
GOTERM_CC_DIRECT |
2034 |
GO:0035035 |
immunoglobulin receptor binding |
GOTERM_MF_DIRECT |
2034 |
GO:0016607 |
nuclear speck |
GOTERM_CC_DIRECT |
2034 |
GO:0003700 |
transcription factor activity |
GOTERM_MF_DIRECT |
2034 |
GO:0001525 |
angiogenesis |
GOTERM_BP_DIRECT |
2034 |
GO:0006366 |
transcription from RNA polymerase II promoter |
GOTERM_BP_DIRECT |
2034 |
GO:0001974 |
blood vessel remodeling |
GOTERM_BP_DIRECT |
2034 |
GO:0048469 |
cell maturation |
GOTERM_BP_DIRECT |
2034 |
GO:0061418 |
regulation of transcription from RNA polymerase II promoter in response to hypoxia |
GOTERM_BP_DIRECT |
2034 |
GO:0005654 |
nucleoplasm |
GOTERM_CC_DIRECT |
2034 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
2034 |
GO:0048625 |
myoblast fate commitment |
GOTERM_BP_DIRECT |
2034 |
GO:0055072 |
iron ion homeostasis |
GOTERM_BP_DIRECT |
2034 |
GO:0043565 |
sequence-specific DNA binding |
GOTERM_MF_DIRECT |
2034 |
GO:0043619 |
regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
GOTERM_BP_DIRECT |
2034 |
GO:0006351 |
transcription |
GOTERM_BP_DIRECT |
2034 |
GO:0030218 |
erythrocyte differentiation |
GOTERM_BP_DIRECT |
2034 |
GO:0043129 |
surfactant homeostasis |
GOTERM_BP_DIRECT |
2034 |
GO:0071456 |
cellular response to hypoxia |
GOTERM_BP_DIRECT |
2034 |
GO:0000981 |
RNA polymerase II transcription factor activity |
GOTERM_MF_DIRECT |
2034 |
GO:0001666 |
response to hypoxia |
GOTERM_BP_DIRECT |
2034 |
GO:0046982 |
protein heterodimerization activity |
GOTERM_MF_DIRECT |
2034 |
GO:0030324 |
lung development |
GOTERM_BP_DIRECT |
2034 |
GO:0005634 |
nucleus |
GOTERM_CC_DIRECT |
2034 |
GO:0005829 |
cytosol |
GOTERM_CC_DIRECT |
2034 |
GO:0001077 |
transcriptional activator activity |
GOTERM_MF_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
2034 |
hsa05200 |
Pathways in cancer |
2034 |
hsa05211 |
Renal cell carcinoma |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
EPAS1 |
2034 |
Benign neoplasm of aortic body and other paraganglia |
C0154045 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Benign neoplasm of adrenal gland |
C0154040 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Malignant neoplasm of aortic body and other paraganglia |
C0438413 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Malignant Adrenal Medulla Neoplasm |
C0344456 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Chromosome Aberrations |
C0008625 |
Cell or Molecular Dysfunction |
0.3 |
0.509 |
0.586 |
group |
EPAS1 |
2034 |
Conventional (Clear Cell) Renal Cell Carcinoma |
C0279702 |
Neoplastic Process |
0.4 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Collecting Duct Carcinoma of the Kidney |
C1266044 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Sarcomatoid Renal Cell Carcinoma |
C1266043 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Renal Cell Carcinoma |
C0007134 |
Neoplastic Process |
0.7 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Papillary Renal Cell Carcinoma |
C1306837 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Autosome Abnormalities |
C0004403 |
Cell or Molecular Dysfunction |
0.3 |
0.509 |
0.586 |
group |
EPAS1 |
2034 |
Neoplastic Cell Transformation |
C0007621 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
phenotype |
EPAS1 |
2034 |
Chromophobe Renal Cell Carcinoma |
C1266042 |
Neoplastic Process |
0.3 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Erythrocytosis, Familial, 4 |
C2673187 |
Disease or Syndrome |
0.6 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Familial erythrocytosis |
C0152264 |
Disease or Syndrome |
0.35 |
0.509 |
0.586 |
disease |
EPAS1 |
2034 |
Secondary polycythemia |
C1318533 |
Disease or Syndrome |
0.3 |
0.509 |
0.586 |
disease |
Association with Drug
Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |
EPAS1 |
2034 |
EZN-2968 |
None |
None |
antisense |