Egl nine homolog 2

AltitudeomicsDB
Protein Official symbol EGLN2
Aliases EGLN2 EIT6
Chromosomal Location  19
Length 407
Uniprot ID Q96KS0
EC number 1.14.11.-; 1.14.11.29
Protein family Information(Pfam) PF13640;
PDB id 5V1B;
InterPro ID IPR005123;IPR006620;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
HIF1A EGLN1 0.999
EGLN1 EPAS1 0.997
EGLN2 HIF1A 0.995
EGLN2 EPAS1 0.994
HIF1A EGLN3 0.991
EPAS1 EGLN3 0.983
HIF3A EGLN3 0.976
EGLN2 HIF3A 0.975
EGLN1 OS9 0.974
HIF3A EGLN1 0.973
HIF1A OS9 0.966
OS9 EGLN3 0.952
HIF3A EPAS1 0.94
HIF1A HIF3A 0.939
EGLN1 EGLN3 0.931
EGLN2 EGLN3 0.931
EGLN2 OS9 0.927
HIF1A EPAS1 0.916
EGLN2 EGLN1 0.907
Gene Ontology Semantic Similarity
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# 3091 (HIF1A) 54583 (EGLN1) 112398 (EGLN2) 2034 (EPAS1) 64344 (HIF3A) 10956 (OS9) 112399 (EGLN3)
3091 (HIF1A) 1.00 0.57 0.54 0.89 1.00 1.00 0.56
54583 (EGLN1) 0.57 1.00 0.93 0.53 0.21 1.00 0.89
112398 (EGLN2) 0.54 0.93 1.00 0.51 0.21 1.00 0.85
2034 (EPAS1) 0.89 0.53 0.51 1.00 1.00 1.00 0.54
64344 (HIF3A) 1.00 0.21 0.21 1.00 1.00 0.21 0.21
10956 (OS9) 1.00 1.00 1.00 1.00 0.21 1.00 1.00
112399 (EGLN3) 0.56 0.89 0.85 0.54 0.21 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
EGLN2 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 11.3 RT-qPCR Western US C57BL/6 mice 1.4 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
EGLN2 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 8.5 RT-qPCR Western US C57BL/6 mice 1.4 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
NR3C1 2908 EGLN2 112398 proximal_filtered 22955619 TRANSFAC
CTCF 10664 EGLN2 112398 proximal_filtered 22955619 TRANSFAC
USF1 7391 EGLN2 112398 proximal_filtered 22955619 TRANSFAC
ARNT 405 EGLN2 112398 Activation 22431919 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT006784 hsa-miR-205-5p Homo sapiens EGLN2 112398 Homo sapiens Luciferase reporter assay//Microarray//qRT-PCR//Western blot Functional MTI 22859986
MIRT049430 hsa-miR-92a-3p Homo sapiens EGLN2 112398 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051206 hsa-miR-16-5p Homo sapiens EGLN2 112398 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT708268 hsa-miR-6829-3p Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT708265 hsa-miR-6836-3p Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT708267 hsa-miR-7977 Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT708273 hsa-miR-4267 Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT708270 hsa-miR-6778-3p Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT708266 hsa-miR-6749-3p Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT708269 hsa-miR-6791-3p Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT708272 hsa-miR-5193 Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT708271 hsa-miR-136-5p Homo sapiens EGLN2 112398 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
Gene Ontology
ID GO ID GO Term GO Type
112398 GO:0016705 oxidoreductase activity GOTERM_MF_DIRECT
112398 GO:0031418 carboxylic acid binding GOTERM_MF_DIRECT
112398 GO:0016491 oxidoreductase activity GOTERM_MF_DIRECT
112398 GO:0019826 oxygen binding GOTERM_MF_DIRECT
112398 GO:0043523 regulation of neuron apoptotic process GOTERM_BP_DIRECT
112398 GO:0045454 cell redox homeostasis GOTERM_BP_DIRECT
112398 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
112398 GO:0005634 nucleus GOTERM_CC_DIRECT
112398 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
112398 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline GOTERM_BP_DIRECT
112398 GO:0045732 positive regulation of protein catabolic process GOTERM_BP_DIRECT
112398 GO:0030520 intracellular estrogen receptor signaling pathway GOTERM_BP_DIRECT
112398 GO:0016706 oxidoreductase activity GOTERM_MF_DIRECT
112398 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
112398 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GOTERM_BP_DIRECT
112398 GO:0005506 iron ion binding GOTERM_MF_DIRECT
112398 GO:0008198 phosphatidate phosphatase activity GOTERM_MF_DIRECT
112398 GO:0001558 regulation of cell growth GOTERM_BP_DIRECT
112398 GO:0005515 protein binding GOTERM_MF_DIRECT
112398 GO:0031545 thyrotropin-releasing hormone receptor binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
112398 hsa04066 HIF-1 signaling pathway
112398 hsa05200 Pathways in cancer
112398 hsa05211 Renal cell carcinoma
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
EGLN2 112398 Malignant neoplasm of aortic body and other paraganglia C0438413 Neoplastic Process 0.3 0.624 0.586 disease
EGLN2 112398 Benign neoplasm of aortic body and other paraganglia C0154045 Neoplastic Process 0.3 0.624 0.586 disease
EGLN2 112398 Benign neoplasm of adrenal gland C0154040 Neoplastic Process 0.3 0.624 0.586 disease
EGLN2 112398 Malignant Adrenal Medulla Neoplasm C0344456 Neoplastic Process 0.3 0.624 0.586 disease
EGLN2 112398 TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) C1861063 Finding 0.3 0.624 0.586 phenotype
EGLN2 112398 Familial erythrocytosis C0152264 Disease or Syndrome 0.3 0.624 0.586 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
EGLN2 112398 AKB-6548 VADADUSTAT CHEMBL3646221 None
EGLN2 112398 COMPOUND 6EE [PMID: 22364528] None None inhibitor
EGLN2 112398 DAPRODUSTAT DAPRODUSTAT CHEMBL3544988 inhibitor
EGLN2 112398 FG-2216 CHEMBL426560 CHEMBL426560 inhibitor
EGLN2 112398 FG-4592 ROXADUSTAT CHEMBL2338329 None
EGLN2 112398 FG-2216 CHEMBL426560 CHEMBL426560 None
EGLN2 112398 FG-4592 ROXADUSTAT CHEMBL2338329 inhibitor
EGLN2 112398 GSK1278863 DAPRODUSTAT CHEMBL3544988 inhibitor
EGLN2 112398 ROXADUSTAT ROXADUSTAT CHEMBL2338329 inhibitor