Krueppel-like factor 4

AltitudeomicsDB
Protein Official symbol KLF4
Aliases KLF4 EZF GKLF
Chromosomal Location  9
Length 513
Uniprot ID O43474
EC number None
Protein family Information(Pfam) PF00096;
PDB id None
InterPro ID IPR036236;IPR013087;
dbSNP rs1059913 rs1059914

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
POU5F1 NANOG 0.999
SOX2 POU5F1 0.999
TCF7L2 CTNNB1 0.998
SMAD4 SMAD2 0.997
SOX2 NANOG 0.997
KLF4 SOX2 0.996
KLF4 NANOG 0.996
LIN28A POU5F1 0.996
LIN28A NANOG 0.994
LIN28A SOX2 0.994
KLF4 POU5F1 0.994
NANOG SALL4 0.994
POU5F1 SALL4 0.994
TCF7L2 EP300 0.992
MYC CTNNB1 0.991
KLF4 LIN28A 0.989
EPAS1 EP300 0.988
CEBPB EP300 0.985
SOX2 SALL4 0.981
MYC TCF7L2 0.979
MYC EP300 0.979
MYC SMAD4 0.978
KLF4 CTNNB1 0.978
CTNNB1 SOX2 0.978
CTNNB1 SMAD4 0.977
CTNNB1 EP300 0.977
LIN28A SALL4 0.976
PRDM14 NANOG 0.975
MYC SMAD2 0.975
PRDM14 POU5F1 0.973
SOX2 PRDM14 0.972
KLF4 SMAD2 0.972
SMAD4 EP300 0.972
EP300 SMAD2 0.972
KLF4 EP300 0.966
LIN28A PRDM14 0.957
PBX1 NANOG 0.957
SMAD2 NANOG 0.956
SMAD2 POU5F1 0.955
POU5F1 ZSCAN10 0.955
SOX2 SMAD2 0.955
MYC KLF4 0.951
ZSCAN10 NANOG 0.95
LIN28A ZSCAN10 0.949
SOX2 ZSCAN10 0.948
SMAD4 CEBPB 0.947
EPAS1 POU5F1 0.945
SMAD4 NANOG 0.944
SMAD4 SOX2 0.944
KLF4 CEBPB 0.943
MYC SOX2 0.943
SMAD4 POU5F1 0.942
PBX1 POU5F1 0.94
KLF4 SMAD4 0.938
PBX1 EP300 0.936
PBX1 SMAD4 0.936
SOX2 EPAS1 0.935
PBX1 SMAD2 0.933
PBX1 SOX2 0.932
MYC POU5F1 0.932
PRDM14 SALL4 0.932
KLF4 SALL4 0.931
TCF7L2 SMAD4 0.929
ZSCAN10 SALL4 0.928
KLF4 PRDM14 0.926
KLF4 EPAS1 0.926
LIN28A SMAD2 0.925
PRDM14 ZSCAN10 0.925
KLF4 TCF7L2 0.923
PBX1 KLF4 0.923
EPAS1 SALL4 0.922
EPAS1 NANOG 0.921
LIN28A SMAD4 0.919
SMAD2 SALL4 0.918
CEBPB SMAD2 0.917
SMAD4 SALL4 0.917
PRDM14 SMAD2 0.915
SMAD4 EPAS1 0.914
KLF4 ZSCAN10 0.911
PBX1 ZSCAN10 0.91
EPAS1 SMAD2 0.909
PBX1 SALL4 0.909
SMAD4 PRDM14 0.909
PBX1 PRDM14 0.908
PRDM14 EPAS1 0.907
SMAD2 ZSCAN10 0.905
SMAD4 ZSCAN10 0.904
LIN28A EPAS1 0.903
PBX1 LIN28A 0.903
EPAS1 ZSCAN10 0.902
PBX1 EPAS1 0.902
Gene Ontology Semantic Similarity
Download Tab separated file
# 5460 (POU5F1) 6657 (SOX2) 6934 (TCF7L2) 4089 (SMAD4) 9314 (KLF4) 79727 (LIN28A) 79923 (NANOG) 4609 (MYC) 2034 (EPAS1) 1051 (CEBPB) 1499 (CTNNB1) 63978 (PRDM14) 2033 (EP300) 5087 (PBX1) 4087 (SMAD2) 84891 (ZSCAN10) 57167 (SALL4)
5460 (POU5F1) 1.00 0.92 0.80 0.78 0.75 0.67 0.85 0.84 0.85 0.86 0.57 0.85 0.52 0.90 0.78 0.78 0.65
6657 (SOX2) 0.92 1.00 0.82 0.81 0.81 0.63 0.87 0.88 0.87 0.85 0.58 0.84 0.50 0.89 0.78 0.82 0.68
6934 (TCF7L2) 0.80 0.82 1.00 0.78 0.82 0.58 0.81 0.87 0.81 0.80 0.73 0.80 0.63 0.82 0.76 0.54 0.68
4089 (SMAD4) 0.78 0.81 0.78 1.00 0.77 0.52 0.83 0.81 0.74 0.79 0.61 0.75 0.56 0.78 0.81 0.58 0.58
9314 (KLF4) 0.75 0.81 0.82 0.77 1.00 0.44 0.79 0.84 0.73 0.76 0.64 0.72 0.51 0.78 0.73 0.61 0.65
79727 (LIN28A) 0.67 0.63 0.58 0.52 0.44 1.00 0.51 0.54 0.65 0.52 0.60 0.55 0.46 0.56 0.57 0.41 0.44
79923 (NANOG) 0.85 0.87 0.81 0.83 0.79 0.51 1.00 0.85 0.81 0.86 0.61 0.84 0.52 0.90 0.76 0.75 0.67
4609 (MYC) 0.84 0.88 0.87 0.81 0.84 0.54 0.85 1.00 0.84 0.84 0.63 0.81 0.58 0.86 0.81 0.64 0.71
2034 (EPAS1) 0.85 0.87 0.81 0.74 0.73 0.65 0.81 0.84 1.00 0.87 0.68 0.86 0.55 0.87 0.74 0.67 0.77
1051 (CEBPB) 0.86 0.85 0.80 0.79 0.76 0.52 0.86 0.84 0.87 1.00 0.58 0.86 0.49 0.91 0.75 0.71 0.74
1499 (CTNNB1) 0.57 0.58 0.73 0.61 0.64 0.60 0.61 0.63 0.68 0.58 1.00 0.63 0.68 0.61 0.63 0.23 0.66
63978 (PRDM14) 0.85 0.84 0.80 0.75 0.72 0.55 0.84 0.81 0.86 0.86 0.63 1.00 0.51 0.93 0.72 0.79 0.68
2033 (EP300) 0.52 0.50 0.63 0.56 0.51 0.46 0.52 0.58 0.55 0.49 0.68 0.51 1.00 0.50 0.56 0.26 0.41
5087 (PBX1) 0.90 0.89 0.82 0.78 0.78 0.56 0.90 0.86 0.87 0.91 0.61 0.93 0.50 1.00 0.75 0.83 0.77
4087 (SMAD2) 0.78 0.78 0.76 0.81 0.73 0.57 0.76 0.81 0.74 0.75 0.63 0.72 0.56 0.75 1.00 0.48 0.62
84891 (ZSCAN10) 0.78 0.82 0.54 0.58 0.61 0.41 0.75 0.64 0.67 0.71 0.23 0.79 0.26 0.83 0.48 1.00 0.69
57167 (SALL4) 0.65 0.68 0.68 0.58 0.65 0.44 0.67 0.71 0.77 0.74 0.66 0.68 0.41 0.77 0.62 0.69 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
KLF4 Toad Heart - 3464 m 33 day upregulated 2.136815145 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
KLF4 9314 BIRC5 332 Activation 12010810 TRUSST
KLF4 9314 ATF3 467 Unknown 16619263 TRUSST
KLF4 9314 CCND1 595 Activation 19051271 TRUSST
KLF4 9314 ALPI 248 Repression 15517885 TRUSST
KLF4 9314 BDKRB2 624 Activation 19814803 TRUSST
KLF4 9314 CCNB1 891 Activation 10961992 TRUSST
KLF4 9314 CD14 929 Unknown 19763505 TRUSST
KLF4 9314 CDH1 999 Unknown 19446338 TRUSST
KLF4 9314 CDH5 1003 Unknown 17998316 TRUSST
KLF4 9314 CDKN1A 1026 Unknown 19139263 TRUSST
KLF4 9314 CDKN1B 1027 Unknown 15541732 TRUSST
KLF4 9314 CDKN1C 1028 Activation 20568120 TRUSST
KLF4 9314 CDX2 1045 Unknown 10196224 TRUSST
KLF4 9314 CYP1A1 1543 Activation 18636947 TRUSST
KLF4 9314 HDC 3067 Unknown 22223884 TRUSST
KLF4 9314 HSPA8 3312 Activation 14585961 TRUSST
KLF4 9314 IVL 3713 Activation 12849008 TRUSST
KLF4 9314 KRT19 3880 Activation 12149223 TRUSST
KLF4 9314 IL1B 3553 Activation 15242350 TRUSST
KLF4 9314 IL6 3569 Repression 18270252 TRUSST
KLF4 9314 LAMA3 3909 Unknown 9199305 TRUSST
KLF4 9314 MMP2 4313 Unknown 14610084 TRUSST
KLF4 9314 ODC1 4953 Repression 11704838 TRUSST
KLF4 9314 PFKP 5214 Unknown 9516823 TRUSST
KLF4 9314 RARA 5914 Unknown 10527846 TRUSST
KLF4 9314 SOD1 6647 Activation 24242046 TRUSST
KLF4 9314 TAGLN 6876 Activation 15772294 TRUSST
KLF4 9314 THBD 7056 Activation 19351864 TRUSST
KLF4 9314 TP53 7157 Activation 7559449 TRUSST
KLF4 9314 VEGFA 7422 Unknown 21408189 TRUSST
KLF4 9314 VDR 7421 Activation 22551584 TRUSST
HDAC4 9759 KLF4 9314 Repression 16423052 TRUSST
SOX9 6662 KLF4 9314 Unknown 10734131 TRUSST
HDAC2 3066 KLF4 9314 Activation 20658750 TRUSST
TP63 8626 KLF4 9314 Unknown 10734131 TRUSST
TCF4 6925 KLF4 9314 Activation 16785240 TRUSST
CDX2 1045 KLF4 9314 Activation 20658750 TRUSST
PPARG 5468 KLF4 9314 Activation 16628196 TRUSST
HDAC1 3065 KLF4 9314 Repression 16423052 TRUSST
RUNX1 100506403861 KLF4 9314 Unknown 22208359 TRUSST
APC 324 KLF4 9314 Repression 21220691 TRUSST
KLF4 9314 GDF15 9518 Unknown 22991139 TRUSST
KLF4 9314 IFITM3 10410 Activation 10779377 TRUSST
KLF4 9314 GPA33 10223 Repression 23836662 TRUSST
KLF4 9314 LXN 56925 Unknown 8861962 TRUSST
KLF4 9314 NANOG 79923 Unknown 16809478 TRUSST
KLF4 9314 ZNF750 79755 Unknown 20482443 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT000308 hsa-miR-145-5p Homo sapiens KLF4 9314 Homo sapiens qRT-PCR Functional MTI (Weak) 23312222
MIRT000308 hsa-miR-145-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 28380435
MIRT000308 hsa-miR-145-5p Homo sapiens KLF4 9314 Homo sapiens qRT-PCR//Western blot Functional MTI 25273883
MIRT000308 hsa-miR-145-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26181633
MIRT000308 hsa-miR-145-5p Homo sapiens KLF4 9314 Homo sapiens Northern blot//qRT-PCR//Western blot Functional MTI 26197891
MIRT000308 hsa-miR-145-5p Homo sapiens KLF4 9314 Homo sapiens FACS//Flow//GFP reporter assay//In situ hybridization//Luciferase reporter assay//qRT-PCR//Reporter assay;Western blot;qRT-PCR Functional MTI 19409607
MIRT003216 hsa-miR-10b-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24573354
MIRT003216 hsa-miR-10b-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26191201
MIRT003216 hsa-miR-10b-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay Functional MTI 27669739
MIRT003216 hsa-miR-10b-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 27764757
MIRT003216 hsa-miR-10b-5p Homo sapiens KLF4 9314 Homo sapiens Flow//qRT-PCR//Western blot Functional MTI 24216130
MIRT003216 hsa-miR-10b-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 20075075
MIRT003605 hsa-miR-25-3p Homo sapiens KLF4 9314 Homo sapiens Western blot Functional MTI 19541842
MIRT003605 hsa-miR-25-3p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay Functional MTI 25923408
MIRT005440 hsa-miR-135b-5p Homo sapiens KLF4 9314 Homo sapiens qRT-PCR Functional MTI (Weak) 26877610
MIRT005440 hsa-miR-135b-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//Microarray//qRT-PCR Functional MTI 20981674
MIRT005674 hsa-miR-130a-3p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//Microarray//qRT-PCR Functional MTI 20981674
MIRT006086 hsa-miR-663a Homo sapiens KLF4 9314 Homo sapiens Microarray//qRT-PCR Functional MTI (Weak) 21378144
MIRT006688 hsa-miR-103a-3p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 22593189
MIRT006688 hsa-miR-103a-3p Homo sapiens KLF4 9314 Homo sapiens Flow//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 28445396
MIRT006692 hsa-miR-107 Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 22593189
MIRT016880 hsa-miR-335-5p Homo sapiens KLF4 9314 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT021926 hsa-miR-128-3p Homo sapiens KLF4 9314 Homo sapiens Flow//qRT-PCR//Western blot Functional MTI 23019226
MIRT021926 hsa-miR-128-3p Homo sapiens KLF4 9314 Homo sapiens Reporter assay Non-Functional MTI 19409607
MIRT022234 hsa-miR-124-3p Homo sapiens KLF4 9314 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT046110 hsa-miR-30b-5p Homo sapiens KLF4 9314 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT053079 hsa-miR-15a-5p Homo sapiens KLF4 9314 Homo sapiens Western blot Functional MTI 23867820
MIRT052916 hsa-miR-29a-3p Homo sapiens KLF4 9314 Homo sapiens Immunoprecipitaion//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24281002
MIRT053423 hsa-miR-624-3p Homo sapiens KLF4 9314 Homo sapiens Microarray Functional MTI (Weak) 23807165
MIRT052916 hsa-miR-29a-3p Homo sapiens KLF4 9314 Homo sapiens Immunofluorescence//qRT-PCR//Reporter assay Functional MTI 22751119
MIRT054372 hsa-miR-34a-5p Homo sapiens KLF4 9314 Homo sapiens Immunoblot//qRT-PCR Functional MTI (Weak) 28250026
MIRT054913 hsa-miR-7-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay Functional MTI 26172296
MIRT054372 hsa-miR-34a-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24415058
MIRT054913 hsa-miR-7-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 28239300
MIRT054372 hsa-miR-34a-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25362853
MIRT054913 hsa-miR-7-5p Homo sapiens KLF4 9314 Homo sapiens Immunoblot//Luciferase reporter assay//qRT-PCR Functional MTI 23384942
MIRT054913 hsa-miR-7-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24200387
MIRT054913 hsa-miR-7-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27431648
MIRT438305 hsa-miR-152-3p Homo sapiens KLF4 9314 Homo sapiens Immunoprecipitaion//qRT-PCR//Western blot//Luciferase reporter assay Functional MTI 25218589
MIRT438288 hsa-miR-137 Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay Functional MTI 24084696
MIRT438357 hsa-miR-206 Homo sapiens KLF4 9314 Homo sapiens Flow//qRT-PCR Functional MTI (Weak) 24855559
MIRT732068 hsa-miR-32-5p Homo sapiens KLF4 9314 Homo sapiens Immunohistochemistry//Immunoprecipitaion//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27871067
MIRT732242 hsa-miR-367-3p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27335771
MIRT732068 hsa-miR-32-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26471298
MIRT733490 hsa-miR-92a-3p Homo sapiens KLF4 9314 Homo sapiens Immunohistochemistry//qRT-PCR//Western blot Functional MTI 27411964
MIRT733676 hsa-miR-135a-5p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27302923
MIRT734061 hsa-miR-29c-3p Homo sapiens KLF4 9314 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26020233
MIRT735418 hsa-miR-375 Homo sapiens KLF4 9314 Homo sapiens qRT-PCR//Western blot Functional MTI 27279635
Gene Ontology
ID GO ID GO Term GO Type
9314 GO:0000122 negative regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
9314 GO:0032270 positive regulation of cellular protein metabolic process GOTERM_BP_DIRECT
9314 GO:0005515 protein binding GOTERM_MF_DIRECT
9314 GO:0042826 Wnt-activated receptor activity GOTERM_MF_DIRECT
9314 GO:0035019 somatic stem cell population maintenance GOTERM_BP_DIRECT
9314 GO:0051973 positive regulation of telomerase activity GOTERM_BP_DIRECT
9314 GO:0071300 cellular response to retinoic acid GOTERM_BP_DIRECT
9314 GO:0045444 fat cell differentiation GOTERM_BP_DIRECT
9314 GO:0045595 regulation of cell differentiation GOTERM_BP_DIRECT
9314 GO:0001190 enhancer sequence-specific DNA binding GOTERM_MF_DIRECT
9314 GO:0034115 negative regulation of heterotypic cell-cell adhesion GOTERM_BP_DIRECT
9314 GO:0043551 regulation of phosphatidylinositol 3-kinase activity GOTERM_BP_DIRECT
9314 GO:0045893 positive regulation of transcription GOTERM_BP_DIRECT
9314 GO:0071499 cellular response to laminar fluid shear stress GOTERM_BP_DIRECT
9314 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GOTERM_BP_DIRECT
9314 GO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell GOTERM_BP_DIRECT
9314 GO:0003676 aminoacyl-tRNA editing activity GOTERM_MF_DIRECT
9314 GO:0044212 transcription regulatory region DNA binding GOTERM_MF_DIRECT
9314 GO:0008285 negative regulation of cell proliferation GOTERM_BP_DIRECT
9314 GO:1901653 cellular response to peptide GOTERM_BP_DIRECT
9314 GO:2000679 positive regulation of transcription regulatory region DNA binding GOTERM_BP_DIRECT
9314 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
9314 GO:0035166 post-embryonic hemopoiesis GOTERM_BP_DIRECT
9314 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GOTERM_BP_DIRECT
9314 GO:0048679 regulation of axon regeneration GOTERM_BP_DIRECT
9314 GO:0051898 negative regulation of protein kinase B signaling GOTERM_BP_DIRECT
9314 GO:0071409 cellular response to cycloheximide GOTERM_BP_DIRECT
9314 GO:0001010 transcription factor activity GOTERM_MF_DIRECT
9314 GO:0031077 post-embryonic camera-type eye development GOTERM_BP_DIRECT
9314 GO:0005719 nuclear euchromatin GOTERM_CC_DIRECT
9314 GO:0007500 mesodermal cell fate determination GOTERM_BP_DIRECT
9314 GO:0019827 stem cell population maintenance GOTERM_BP_DIRECT
9314 GO:0032088 negative regulation of NF-kappaB transcription factor activity GOTERM_BP_DIRECT
9314 GO:0048730 epidermis morphogenesis GOTERM_BP_DIRECT
9314 GO:0070373 negative regulation of ERK1 and ERK2 cascade GOTERM_BP_DIRECT
9314 GO:0071363 cellular response to growth factor stimulus GOTERM_BP_DIRECT
9314 GO:2000342 negative regulation of chemokine GOTERM_BP_DIRECT
9314 GO:0001221 transcriptional activator activity GOTERM_MF_DIRECT
9314 GO:0044798 nuclear transcription factor complex GOTERM_CC_DIRECT
9314 GO:0006366 transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
9314 GO:0001047 RNA polymerase II regulatory region DNA binding GOTERM_MF_DIRECT
9314 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
9314 GO:0010628 positive regulation of gene expression GOTERM_BP_DIRECT
9314 GO:0045892 negative regulation of transcription GOTERM_BP_DIRECT
9314 GO:0048662 negative regulation of smooth muscle cell proliferation GOTERM_BP_DIRECT
9314 GO:0000987 transcription factor activity GOTERM_MF_DIRECT
9314 GO:0003700 transcription factor activity GOTERM_MF_DIRECT
9314 GO:0060761 negative regulation of response to cytokine stimulus GOTERM_BP_DIRECT
9314 GO:0001077 transcriptional activator activity GOTERM_MF_DIRECT
9314 GO:0035014 hypophosphite dioxygenase activity GOTERM_MF_DIRECT
9314 GO:0045415 negative regulation of interleukin-8 biosynthetic process GOTERM_BP_DIRECT
9314 GO:0045429 positive regulation of nitric oxide biosynthetic process GOTERM_BP_DIRECT
9314 GO:0051247 positive regulation of protein metabolic process GOTERM_BP_DIRECT
9314 GO:0001085 transcriptional repressor activity GOTERM_MF_DIRECT
9314 GO:0008013 chemokine activity GOTERM_MF_DIRECT
9314 GO:0000790 nuclear chromatin GOTERM_CC_DIRECT
9314 GO:0009913 epidermal cell differentiation GOTERM_BP_DIRECT
9314 GO:0014740 negative regulation of muscle hyperplasia GOTERM_BP_DIRECT
9314 GO:0046985 positive regulation of hemoglobin biosynthetic process GOTERM_BP_DIRECT
9314 GO:0070301 cellular response to hydrogen peroxide GOTERM_BP_DIRECT
9314 GO:0010629 negative regulation of gene expression GOTERM_BP_DIRECT
9314 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling GOTERM_BP_DIRECT
9314 GO:0050728 negative regulation of inflammatory response GOTERM_BP_DIRECT
9314 GO:0046872 metal ion binding GOTERM_MF_DIRECT
9314 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
9314 GO:0060070 canonical Wnt signaling pathway GOTERM_BP_DIRECT
9314 GO:0005737 cytoplasm GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
9314 hsa04550 Signaling pathways regulating pluripotency of stem cells
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
KLF4 9314 Meningioma C0025286 Neoplastic Process 0.31 0.498 0.655 disease
KLF4 9314 Juvenile-Onset Still Disease C0087031 Disease or Syndrome 0.3 0.498 0.655 disease
KLF4 9314 Congenital Abnormality C0000768 Congenital Abnormality 0.3 0.498 0.655 group
KLF4 9314 Thrombus C0087086 Pathologic Function 0.3 0.498 0.655 phenotype
KLF4 9314 Congenital Heart Defects C0018798 Congenital Abnormality 0.3 0.498 0.655 group
KLF4 9314 Thrombosis C0040053 Pathologic Function 0.3 0.498 0.655 phenotype
KLF4 9314 Juvenile psoriatic arthritis C3714758 Disease or Syndrome 0.3 0.498 0.655 disease
KLF4 9314 Myocardial Ischemia C0151744 Disease or Syndrome 0.3 0.498 0.655 disease
KLF4 9314 Juvenile arthritis C3495559 Disease or Syndrome 0.3 0.498 0.655 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types