ALTITUDEOMICSDB

Transcription factor 7-like 2

AltitudeomicsDB

Protein Official symbol	TCF7L2
Aliases	TCF7L2 TCF4
Chromosomal Location	10
Length	619
Uniprot ID	Q9NQB0
EC number	None
Protein family Information(Pfam)	PF08347;PF00505;
PDB id	1JDH;1JPW;2GL7;
InterPro ID	IPR027397;IPR013558;IPR009071;IPR036910;IPR024940;
dbSNP	rs2757884

Protein Protein Interaction

Download Tab separated file

AltitudeomicsDB

Protein 1	Protein 2	Combine Score
CTNNB1	APC	0.999
BTRC	CTNNB1	0.999
CTNNB1	LEF1	0.999
AXIN1	APC	0.999
CTNNB1	BCL9	0.999
JUN	FOS	0.999
CUL1	SKP1	0.999
CTNNB1	AXIN1	0.999
TCF7L2	CTNNB1	0.998
TRRAP	KAT5	0.998
CTNNB1	AXIN2	0.996
CTNNB1	CCND1	0.995
AXIN2	APC	0.994
BTRC	SKP1	0.993
BTRC	CUL1	0.993
SMARCA4	TERT	0.993
RUVBL2	TRRAP	0.993
RUVBL2	KAT5	0.993
TCF7L2	EP300	0.992
MYC	JUN	0.992
HDAC1	EP300	0.991
MYC	CTNNB1	0.991
EP300	CREBBP	0.99
KAT5	EP300	0.989
MYC	TERT	0.989
NLK	TCF7L2	0.988
SMARCA4	HDAC1	0.988
KAT5	H2AFZ	0.988
HDAC1	KAT5	0.988
AXIN2	LEF1	0.988
HDAC1	CREBBP	0.988
TCF7L2	AXIN2	0.987
TCF7L2	CREBBP	0.987
AR	CCND1	0.986
CTNNB1	DVL3	0.986
PYGO2	BCL9	0.986
NLK	LEF1	0.986
HDAC2	CREBBP	0.985
TLE3	TCF7L2	0.985
JUN	CCND1	0.985
HDAC2	HDAC1	0.985
SMARCA4	CREBBP	0.985
AR	CTNNB1	0.984
CTNNB1	SKP1	0.984
HDAC2	EP300	0.984
CTNNB1	CREBBP	0.984
TLE1	TCF7L2	0.983
SMARCA4	CTNNB1	0.983
TLE4	TCF7L2	0.983
KAT5	HIST1H2BA	0.983
AR	KAT5	0.982
MYC	TRRAP	0.981
MYC	LEF1	0.981
MYC	KAT5	0.981
JUN	CTNNB1	0.981
AR	EP300	0.98
HDAC1	CTBP1	0.98
MYC	RUVBL2	0.98
MYC	TCF7L2	0.979
JUN	EP300	0.979
NLK	CTNNB1	0.979
MYC	EP300	0.979
MYC	SMAD4	0.978
HDAC2	HIST1H2BA	0.978
KLF4	CTNNB1	0.978
LEF1	EP300	0.978
MYC	AXIN1	0.977
TLE1	HDAC1	0.977
CTNNB1	CTBP1	0.977
CTNNB1	EP300	0.977
HDAC1	TBL1X	0.977
CTNNB1	SMAD4	0.977
HDAC1	CCND1	0.976
CDC73	CTNNB1	0.976
PYGO2	CTNNB1	0.976
HDAC1	TCF7L2	0.976
KAT5	H2AFV	0.976
HDAC2	TCF7L2	0.975
AR	CREBBP	0.975
BTRC	AXIN1	0.975
TBL1XR1	HDAC1	0.975
TLE3	HDAC1	0.975
TLE1	LEF1	0.975
HDAC2	CTBP1	0.975
H2AFZ	HIST1H2BA	0.975
CTNNB1	SOX17	0.975
CTNNB1	TBL1X	0.975
CTNNB1	MEN1	0.975
JUN	CREBBP	0.974
JUN	SMAD4	0.974
GCG	TCF7L2	0.974
HDAC2	TBL1X	0.974
NLK	SMAD4	0.973
SMAD4	CCND1	0.973
HDAC1	JUN	0.973
HDAC1	HIST1H2BA	0.972
H2AFV	HIST1H2BA	0.972
HDAC2	H2AFZ	0.972
SMAD4	EP300	0.972
HDAC2	TBL1XR1	0.972
RUNX3	CCND1	0.971
CTNNB1	TERT	0.971
RUVBL2	TERT	0.971
DVL3	AXIN1	0.971
H2AFZ	EP300	0.971
HDAC1	FOS	0.971
MYC	CREBBP	0.97
HDAC1	H2AFZ	0.97
FOS	EP300	0.97
EP300	CCND1	0.97
TLE1	CTNNB1	0.969
LEF1	CCND1	0.969
HIST1H2BA	EP300	0.969
TCF7L2	APC	0.968
HDAC1	LEF1	0.968
JUP	CTNNB1	0.968
TLE2	LEF1	0.967
MYC	H2AFZ	0.967
JUP	APC	0.967
TLE4	HDAC1	0.967
FOS	CCND1	0.967
MYC	RUNX3	0.967
KLF4	EP300	0.966
LEF1	APC	0.965
HDAC1	CTNNB1	0.965
MYC	CCND1	0.964
CREBBP	CCND1	0.964
H2AFZ	CREBBP	0.964
RUVBL2	CTNNB1	0.964
HDAC1	SMAD4	0.963
SMARCA4	CCND1	0.963
CTNNB1	BCL9L	0.963
LEF1	CREBBP	0.962
SMAD4	CREBBP	0.962
HIST1H2BA	CREBBP	0.962
RUNX3	TCF7L2	0.962
CUL1	CCND1	0.961
CTNNB1	SOX4	0.961
SKP1	CCND1	0.961
PYGO2	LEF1	0.961
AR	SMAD4	0.96
TCF7L2	CCND1	0.959
CTBP2	CTBP1	0.959
TLE1	CTBP1	0.959
SMAD4	LEF1	0.958
RUNX3	EP300	0.958
HDAC2	JUN	0.958
CTBP1	CREBBP	0.957
TCF7L2	CTBP1	0.957
TRRAP	H2AFZ	0.957
CTNNB1	CUL1	0.956
PYGO2	BCL9L	0.956
RUNX3	CTNNB1	0.956
HDAC1	CTBP2	0.955
CTBP1	APC	0.955
BTRC	APC	0.955
TNIK	CTNNB1	0.955
TRRAP	CTNNB1	0.954
TLE4	LEF1	0.954
SMARCA4	JUN	0.954
HDAC1	MEN1	0.954
TRRAP	SKP1	0.954
TBL1XR1	CTNNB1	0.954
HDAC1	H2AFV	0.953
TCF7L2	AXIN1	0.952
TCF7L2	DVL3	0.952
MYC	HBP1	0.951
HDAC2	H2AFV	0.951
MYC	KLF4	0.951
H2AFV	EP300	0.95
LEF1	BCL9	0.95
H2AFV	CREBBP	0.95
TCF7L2	HBP1	0.949
TLE3	CREBBP	0.949
FOS	H2AFZ	0.948
LEF1	SOX4	0.948
TLE1	CTBP2	0.948
TNIK	TCF7L2	0.948
AXIN2	AXIN1	0.948
TLE4	CTBP2	0.948
TLE3	CTNNB1	0.948
FOS	HIST1H2BA	0.948
AR	TCF7L2	0.948
BTRC	BCL9	0.947
HIST1H2BA	CCND1	0.947
H2AFZ	CCND1	0.947
AR	HIST1H2BA	0.947
HDAC1	TRRAP	0.947
NLK	CREBBP	0.946
TLE3	LEF1	0.946
TLE3	CTBP1	0.946
MYC	CTBP1	0.945
RUNX3	SMAD4	0.945
TLE4	CTNNB1	0.945
TRRAP	CUL1	0.945
TCF7L2	LEF1	0.944
DVL3	APC	0.944
TRRAP	H2AFV	0.944
TLE4	CTBP1	0.943
TLE2	HDAC1	0.943
HDAC1	CDC73	0.942
CTNNB1	FOS	0.942
TBL1XR1	CREBBP	0.942
SMAD4	MEN1	0.941
JUP	TCF7L2	0.941
SOX17	LEF1	0.94
MYC	HIST1H2BA	0.94
SMAD4	FOS	0.94
TCF7L2	MEN1	0.94
TLE3	CTBP2	0.94
BTRC	TCF7L2	0.939
JUN	HIST1H2BA	0.939
HDAC2	SMAD4	0.939
TLE2	TCF7L2	0.939
MEN1	LEF1	0.939
JUP	LEF1	0.938
HDAC1	TERT	0.938
KLF4	SMAD4	0.938
CUL1	CREBBP	0.938
MYC	TLE1	0.937
TLE2	CTBP1	0.937
TBL1XR1	TBL1X	0.936
BTRC	LEF1	0.936
TCF7L2	TBL1X	0.935
TLE1	TBL1X	0.935
CTBP1	LEF1	0.935
JUN	DVL3	0.934
CUL1	EP300	0.934
SMAD4	CTBP1	0.934
EP300	SKP1	0.934
TBL1XR1	TCF7L2	0.933
TCF7L2	CDC73	0.933
RUNX3	LEF1	0.933
H2AFV	BCL9	0.932
HDAC2	CTNNB1	0.932
CTNNB1	HIST1H2BA	0.932
TCF7L2	BCL9L	0.932
JUN	TCF7L2	0.932
CTBP1	CCND1	0.932
TBL1XR1	EP300	0.932
TLE1	BCL9	0.931
H2AFZ	BCL9	0.931
AXIN1	SKP1	0.929
TCF7L2	SMAD4	0.929
TRRAP	HIST1H2BA	0.929
CTNNB1	KAT5	0.929
TLE2	CTBP2	0.928
CREBBP	SKP1	0.928
CREBBP	TBL1X	0.928
TLE2	TLE1	0.928
PYGO2	CTBP1	0.928
EP300	TBL1X	0.928
APC	BCL9	0.928
AR	H2AFZ	0.928
TLE2	BCL9	0.927
MEN1	HIST1H2BA	0.927
TCF7L2	SOX4	0.926
CTNNB1	H2AFV	0.926
TCF7L2	CTBP2	0.926
TLE1	EP300	0.925
JUN	H2AFZ	0.925
CTBP2	LEF1	0.925
TLE2	CTNNB1	0.925
TCF7L2	H2AFZ	0.925
SOX13	LEF1	0.924
JUN	H2AFV	0.924
MYC	H2AFV	0.924
HDAC2	CTBP2	0.924
TCF7L2	H2AFV	0.924
KLF4	TCF7L2	0.923
SMARCA4	LEF1	0.923
GCG	CTNNB1	0.923
TLE1	CCND1	0.923
TLE3	PYGO2	0.923
BCL9L	APC	0.923
TLE4	PYGO2	0.923
CUL1	AXIN1	0.923
TCF7L2	SOX17	0.923
RUNX3	CREBBP	0.923
HIST1H2BA	BCL9	0.923
BTRC	BCL9L	0.922
TBL1XR1	TLE1	0.922
TCF7L2	BCL9	0.922
BCL9L	BCL9	0.922
RUVBL2	TCF7L2	0.922
BCL9L	LEF1	0.922
SOX13	CTNNB1	0.921
KAT5	LEF1	0.92
APC	SKP1	0.92
TLE1	TRRAP	0.92
TLE1	PYGO2	0.92
TCF7L2	CUL1	0.919
TCF7L2	KAT5	0.919
AR	H2AFV	0.919
TCF7L2	PYGO2	0.919
TCF7L2	SKP1	0.919
TLE1	APC	0.919
HDAC1	BTRC	0.918
MEN1	H2AFZ	0.918
TCF7L2	TRRAP	0.918
MEN1	BCL9	0.918
TLE3	SMARCA4	0.918
TLE3	EP300	0.917
HDAC1	BCL9	0.917
CDC73	HIST1H2BA	0.917
TCF7L2	FOS	0.917
TERT	LEF1	0.917
SMARCA4	TLE1	0.917
TLE1	CREBBP	0.917
CTBP1	BCL9	0.917
TLE1	KAT5	0.917
H2AFV	H2AFZ	0.916
TCF7L2	SOX13	0.916
TLE1	SMAD4	0.916
MYC	FOS	0.915
BTRC	CTBP1	0.915
CTNNB1	H2AFZ	0.914
MEN1	H2AFV	0.914
TCF7L2	HIST1H2BA	0.914
TLE3	BCL9	0.913
HIST1H2BA	LEF1	0.913
CTNNB1	HBP1	0.912
TLE4	EP300	0.912
TCF7L2	TERT	0.912
SMARCA4	TCF7L2	0.912
H2AFZ	LEF1	0.911
TLE2	EP300	0.911
TLE3	APC	0.911
MEN1	CTBP1	0.911
PYGO2	APC	0.911
TLE4	CREBBP	0.911
LEF1	AXIN1	0.911
TLE4	APC	0.91
TLE2	PYGO2	0.909
TLE3	BTRC	0.909
H2AFV	LEF1	0.909
TRRAP	LEF1	0.909
BCL9L	CTBP1	0.909
NLK	TLE1	0.909
CUL1	APC	0.909
TLE1	BTRC	0.909
HDAC1	APC	0.908
TLE1	CDC73	0.908
PYGO2	H2AFV	0.907
H2AFV	CCND1	0.907
PYGO2	H2AFZ	0.907
TLE2	CREBBP	0.907
PYGO2	MEN1	0.907
BTRC	TRRAP	0.907
TLE3	CDC73	0.906
TLE3	TRRAP	0.906
NLK	CTBP1	0.906
TLE4	TRRAP	0.906
BTRC	PYGO2	0.905
TLE4	CDC73	0.905
TLE2	APC	0.905
HDAC1	PYGO2	0.905
TLE3	KAT5	0.905
TLE1	BCL9L	0.904
TLE2	SMARCA4	0.904
SMARCA4	TLE4	0.904
TLE4	KAT5	0.903
MEN1	APC	0.903
HIST1H2BA	TBL1X	0.903
TBL1XR1	HIST1H2BA	0.903
MEN1	BCL9L	0.903
TLE2	TRRAP	0.903
CDC73	LEF1	0.903
TLE2	TLE3	0.902
TLE4	BCL9L	0.902
TLE4	BCL9	0.902
TLE4	BTRC	0.902
TLE2	KAT5	0.902
TLE2	BTRC	0.902
TLE3	BCL9L	0.902
TLE3	MEN1	0.902
TLE2	BCL9L	0.902
TLE2	TLE4	0.902
H2AFV	FOS	0.902
TLE4	TLE1	0.901
TLE3	TLE1	0.901
TLE3	TLE4	0.901
BCL9L	H2AFZ	0.9
TLE1	MEN1	0.9
TLE4	MEN1	0.9
TLE1	TERT	0.9
HDAC1	BCL9L	0.9
TLE4	TERT	0.9
TLE3	TERT	0.9
TLE2	CDC73	0.9
BTRC	MEN1	0.9
TLE2	TERT	0.9
BCL9L	H2AFV	0.9
TLE2	MEN1	0.9
PYGO2	HIST1H2BA	0.9
BCL9L	HIST1H2BA	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	1499 (CTNNB1)	8945 (BTRC)	8312 (AXIN1)	3725 (JUN)	8454 (CUL1)	6934 (TCF7L2)	8295 (TRRAP)	8313 (AXIN2)	6597 (SMARCA4)	10856 (RUVBL2)	4609 (MYC)	3065 (HDAC1)	2033 (EP300)	10524 (KAT5)	51701 (NLK)	367 (AR)	90780 (PYGO2)	3066 (HDAC2)	7090 (TLE3)	7088 (TLE1)	7091 (TLE4)	9314 (KLF4)	51176 (LEF1)	79577 (CDC73)	79718 (TBL1XR1)	3015 (H2AFZ)	2641 (GCG)	4089 (SMAD4)	94239 (H2AFV)	864 (RUNX3)	1857 (DVL3)	2353 (FOS)	255626 (HIST1H2BA)	3728 (JUP)	7089 (TLE2)	1387 (CREBBP)	6500 (SKP1)	1488 (CTBP2)	1487 (CTBP1)	23043 (TNIK)	64321 (SOX17)	4221 (MEN1)	324 (APC)	9580 (SOX13)	283149 (BCL9L)	7015 (TERT)	607 (BCL9)	595 (CCND1)	6907 (TBL1X)	6659 (SOX4)	26959 (HBP1)
1499 (CTNNB1)	1.00	0.63	0.76	0.64	0.64	0.73	0.70	0.73	0.73	0.63	0.63	0.67	0.68	0.73	0.62	0.68	1.00	0.66	0.72	0.76	0.71	0.64	0.61	0.68	0.71	0.60	0.71	0.61	0.35	0.60	0.71	0.66	0.35	0.80	0.72	0.70	0.66	0.72	0.75	0.63	0.65	0.65	0.68	0.63	0.62	0.57	1.00	0.72	0.75	0.63	0.66
8945 (BTRC)	0.63	1.00	0.68	0.52	0.86	0.59	0.49	0.67	0.51	0.51	0.51	0.54	0.52	0.53	0.53	0.55	1.00	0.57	0.54	0.60	0.56	0.44	0.52	0.55	0.64	0.51	0.64	0.49	0.46	0.45	0.66	0.52	0.46	0.56	0.54	0.52	0.91	0.58	0.60	0.56	0.55	0.58	0.62	0.53	0.50	0.62	1.00	0.57	0.67	0.41	0.53
8312 (AXIN1)	0.76	0.68	1.00	0.61	0.71	0.69	0.67	0.85	0.60	0.62	0.58	0.60	0.51	0.61	0.64	0.63	1.00	0.61	0.70	0.75	0.69	0.56	0.57	0.72	0.72	0.59	0.77	0.61	0.36	0.62	0.76	0.62	0.36	0.72	0.70	0.56	0.72	0.78	0.71	0.66	0.66	0.63	0.80	0.65	0.61	0.59	1.00	0.70	0.74	0.57	0.70
3725 (JUN)	0.64	0.52	0.61	1.00	0.47	0.79	0.49	0.53	0.66	0.61	0.82	0.70	0.60	0.50	0.48	0.81	1.00	0.66	0.50	0.56	0.54	0.76	0.79	0.46	0.64	0.66	0.52	0.84	0.46	0.72	0.53	0.85	0.46	0.57	0.50	0.74	0.47	0.47	0.55	0.43	0.79	0.63	0.56	0.73	0.43	0.60	1.00	0.55	0.67	0.79	0.62
8454 (CUL1)	0.64	0.86	0.71	0.47	1.00	0.53	0.48	0.74	0.49	0.46	0.46	0.52	0.47	0.53	0.58	0.50	1.00	0.50	0.54	0.60	0.56	0.40	0.44	0.56	0.58	0.40	0.65	0.42	0.36	0.41	0.64	0.48	0.36	0.56	0.54	0.49	0.91	0.59	0.59	0.56	0.49	0.51	0.65	0.47	0.43	0.52	1.00	0.58	0.62	0.37	0.52
6934 (TCF7L2)	0.73	0.59	0.69	0.79	0.53	1.00	0.53	0.63	0.66	0.62	0.87	0.72	0.63	0.55	0.53	0.86	1.00	0.74	0.58	0.62	0.60	0.82	0.86	0.56	0.70	0.71	0.61	0.78	0.46	0.76	0.63	0.83	0.46	0.60	0.58	0.73	0.60	0.66	0.63	0.52	0.84	0.71	0.65	0.80	0.48	0.59	1.00	0.59	0.74	0.78	0.68
8295 (TRRAP)	0.70	0.49	0.67	0.49	0.48	0.53	1.00	0.65	0.60	0.55	0.45	0.57	0.45	0.57	0.45	0.49	1.00	0.50	0.75	0.77	0.72	0.43	0.43	0.55	0.73	0.38	0.66	0.50	0.38	0.39	0.64	0.47	0.38	0.65	0.75	0.51	0.58	0.59	0.72	0.45	0.48	0.49	0.60	0.45	0.68	0.45	1.00	0.62	0.74	0.48	0.51
8313 (AXIN2)	0.73	0.67	0.85	0.53	0.74	0.63	0.65	1.00	0.57	0.55	0.54	0.57	0.46	0.57	0.62	0.60	1.00	0.57	0.73	0.75	0.70	0.49	0.51	0.79	0.75	0.52	0.80	0.49	0.40	0.56	0.81	0.57	0.40	0.65	0.73	0.51	0.74	0.79	0.71	0.64	0.64	0.58	0.78	0.63	0.69	0.50	1.00	0.67	0.76	0.49	0.74
6597 (SMARCA4)	0.73	0.51	0.60	0.66	0.49	0.66	0.60	0.57	1.00	0.80	0.62	0.81	0.62	0.63	0.49	0.62	1.00	0.70	0.64	0.68	0.64	0.58	0.60	0.51	0.74	0.74	0.57	0.64	0.38	0.58	0.57	0.66	0.38	0.63	0.64	0.66	0.53	0.53	0.67	0.48	0.58	0.59	0.55	0.54	0.54	0.52	1.00	0.62	0.75	0.68	0.50
10856 (RUVBL2)	0.63	0.51	0.62	0.61	0.46	0.62	0.55	0.55	0.80	1.00	0.56	0.72	0.54	0.50	0.45	0.58	1.00	0.65	0.59	0.64	0.59	0.52	0.58	0.47	0.69	0.73	0.56	0.60	0.40	0.54	0.56	0.61	0.40	0.56	0.59	0.56	0.53	0.51	0.62	0.44	0.56	0.57	0.57	0.52	0.49	0.52	1.00	0.56	0.71	0.57	0.46
4609 (MYC)	0.63	0.51	0.58	0.82	0.46	0.87	0.45	0.54	0.62	0.56	1.00	0.69	0.58	0.48	0.48	0.87	1.00	0.67	0.53	0.59	0.56	0.84	0.81	0.48	0.63	0.68	0.55	0.81	0.50	0.78	0.55	0.87	0.50	0.52	0.53	0.74	0.51	0.56	0.59	0.44	0.86	0.66	0.54	0.82	0.38	0.56	1.00	0.52	0.68	0.83	0.71
3065 (HDAC1)	0.67	0.54	0.60	0.70	0.52	0.72	0.57	0.57	0.81	0.72	0.69	1.00	0.63	0.56	0.53	0.69	1.00	0.89	0.61	0.66	0.62	0.64	0.65	0.51	0.72	0.74	0.55	0.66	0.41	0.61	0.56	0.71	0.41	0.56	0.61	0.68	0.54	0.53	0.65	0.49	0.65	0.64	0.55	0.57	0.45	0.57	1.00	0.64	0.75	0.66	0.50
2033 (EP300)	0.68	0.52	0.51	0.60	0.47	0.63	0.45	0.46	0.62	0.54	0.58	0.63	1.00	0.72	0.47	0.60	1.00	0.61	0.46	0.51	0.49	0.51	0.59	0.41	0.54	0.56	0.47	0.56	0.36	0.44	0.49	0.56	0.36	0.54	0.46	0.79	0.52	0.45	0.53	0.44	0.50	0.56	0.48	0.46	0.42	0.58	1.00	0.52	0.59	0.51	0.41
10524 (KAT5)	0.73	0.53	0.61	0.50	0.53	0.55	0.57	0.57	0.63	0.50	0.48	0.56	0.72	1.00	0.50	0.49	1.00	0.49	0.64	0.67	0.65	0.43	0.47	0.50	0.63	0.40	0.58	0.47	0.33	0.41	0.58	0.47	0.33	0.64	0.64	0.73	0.59	0.52	0.65	0.49	0.48	0.48	0.55	0.45	0.55	0.49	1.00	0.59	0.67	0.49	0.48
51701 (NLK)	0.62	0.53	0.64	0.48	0.58	0.53	0.45	0.62	0.49	0.45	0.48	0.53	0.47	0.50	1.00	0.52	1.00	0.51	0.50	0.57	0.52	0.45	0.44	0.49	0.53	0.41	0.57	0.44	0.32	0.54	0.57	0.49	0.32	0.53	0.50	0.50	0.59	0.52	0.60	0.78	0.49	0.48	0.59	0.45	0.39	0.54	1.00	0.71	0.60	0.39	0.47
367 (AR)	0.68	0.55	0.63	0.81	0.50	0.86	0.49	0.60	0.62	0.58	0.87	0.69	0.60	0.49	0.52	1.00	1.00	0.69	0.53	0.57	0.55	0.83	0.83	0.52	0.64	0.66	0.59	0.79	0.44	0.74	0.61	0.82	0.44	0.55	0.53	0.74	0.54	0.56	0.58	0.49	0.81	0.66	0.57	0.76	0.44	0.57	1.00	0.56	0.68	0.78	0.68
90780 (PYGO2)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.48	1.00	1.00	1.00	0.48	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00
3066 (HDAC2)	0.66	0.57	0.61	0.66	0.50	0.74	0.50	0.57	0.70	0.65	0.67	0.89	0.61	0.49	0.51	0.69	1.00	1.00	0.51	0.57	0.53	0.58	0.67	0.50	0.59	0.76	0.54	0.62	0.46	0.55	0.56	0.64	0.46	0.53	0.51	0.64	0.53	0.54	0.57	0.47	0.58	0.64	0.55	0.58	0.39	0.62	1.00	0.57	0.64	0.56	0.48
7090 (TLE3)	0.72	0.54	0.70	0.50	0.54	0.58	0.75	0.73	0.64	0.59	0.53	0.61	0.46	0.64	0.50	0.53	1.00	0.51	1.00	0.96	0.93	0.46	0.46	0.66	0.82	0.44	0.72	0.51	0.39	0.46	0.69	0.53	0.39	0.67	1.00	0.53	0.63	0.68	0.87	0.52	0.55	0.52	0.64	0.53	0.72	0.46	1.00	0.69	0.84	0.51	0.62
7088 (TLE1)	0.76	0.60	0.75	0.56	0.60	0.62	0.77	0.75	0.68	0.64	0.59	0.66	0.51	0.67	0.57	0.57	1.00	0.57	0.96	1.00	0.90	0.52	0.48	0.70	0.82	0.50	0.78	0.56	0.39	0.53	0.71	0.60	0.39	0.70	0.96	0.59	0.66	0.71	0.89	0.60	0.63	0.56	0.69	0.59	0.70	0.52	1.00	0.73	0.86	0.56	0.67
7091 (TLE4)	0.71	0.56	0.69	0.54	0.56	0.60	0.72	0.70	0.64	0.59	0.56	0.62	0.49	0.65	0.52	0.55	1.00	0.53	0.93	0.90	1.00	0.50	0.49	0.63	0.79	0.44	0.70	0.54	0.58	0.50	0.67	0.55	0.58	0.70	0.93	0.56	0.64	0.65	0.84	0.55	0.59	0.53	0.64	0.57	0.66	0.49	1.00	0.70	0.81	0.55	0.62
9314 (KLF4)	0.64	0.44	0.56	0.76	0.40	0.82	0.43	0.49	0.58	0.52	0.84	0.64	0.51	0.43	0.45	0.83	1.00	0.58	0.46	0.52	0.50	1.00	0.76	0.42	0.62	0.56	0.50	0.77	0.43	0.74	0.51	0.81	0.43	0.51	0.46	0.71	0.46	0.48	0.53	0.38	0.80	0.60	0.51	0.75	0.37	0.48	1.00	0.48	0.65	0.81	0.65
51176 (LEF1)	0.61	0.52	0.57	0.79	0.44	0.86	0.43	0.51	0.60	0.58	0.81	0.65	0.59	0.47	0.44	0.83	1.00	0.67	0.46	0.48	0.49	0.76	1.00	0.45	0.65	0.68	0.50	0.77	0.49	0.71	0.52	0.77	0.49	0.51	0.46	0.68	0.50	0.49	0.51	0.43	0.78	0.66	0.53	0.74	0.38	0.57	1.00	0.49	0.67	0.73	0.59
79577 (CDC73)	0.68	0.55	0.72	0.46	0.56	0.56	0.55	0.79	0.51	0.47	0.48	0.51	0.41	0.50	0.49	0.52	1.00	0.50	0.66	0.70	0.63	0.42	0.45	1.00	0.66	0.43	0.76	0.44	0.37	0.46	0.72	0.52	0.37	0.60	0.66	0.46	0.65	0.72	0.67	0.54	0.54	0.53	0.66	0.54	0.54	0.46	1.00	0.57	0.69	0.40	0.66
79718 (TBL1XR1)	0.71	0.64	0.72	0.64	0.58	0.70	0.73	0.75	0.74	0.69	0.63	0.72	0.54	0.63	0.53	0.64	1.00	0.59	0.82	0.82	0.79	0.62	0.65	0.66	1.00	0.67	0.71	0.67	0.49	0.60	0.72	0.69	0.49	0.67	0.82	0.60	0.67	0.68	0.78	0.57	0.71	0.71	0.67	0.64	0.72	0.57	1.00	0.68	0.95	0.66	0.64
3015 (H2AFZ)	0.60	0.51	0.59	0.66	0.40	0.71	0.38	0.52	0.74	0.73	0.68	0.74	0.56	0.40	0.41	0.66	1.00	0.76	0.44	0.50	0.44	0.56	0.68	0.43	0.67	1.00	0.53	0.66	0.61	0.61	0.54	0.72	0.61	0.50	0.44	0.58	0.48	0.49	0.52	0.38	0.59	0.68	0.53	0.61	0.34	0.58	1.00	0.46	0.69	0.60	0.41
2641 (GCG)	0.71	0.64	0.77	0.52	0.65	0.61	0.66	0.80	0.57	0.56	0.55	0.55	0.47	0.58	0.57	0.59	1.00	0.54	0.72	0.78	0.70	0.50	0.50	0.76	0.71	0.53	1.00	0.52	0.39	0.57	0.81	0.58	0.39	0.67	0.72	0.52	0.70	0.76	0.71	0.65	0.62	0.59	0.72	0.64	0.60	0.54	1.00	0.62	0.73	0.51	0.73
4089 (SMAD4)	0.61	0.49	0.61	0.84	0.42	0.78	0.50	0.49	0.64	0.60	0.81	0.66	0.56	0.47	0.44	0.79	1.00	0.62	0.51	0.56	0.54	0.77	0.77	0.44	0.67	0.66	0.52	1.00	0.49	0.70	0.50	0.79	0.49	0.57	0.51	0.69	0.47	0.46	0.55	0.41	0.74	0.65	0.52	0.74	0.42	0.59	1.00	0.50	0.68	0.81	0.58
94239 (H2AFV)	0.35	0.46	0.36	0.46	0.36	0.46	0.38	0.40	0.38	0.40	0.50	0.41	0.36	0.33	0.32	0.44	0.48	0.46	0.39	0.39	0.58	0.43	0.49	0.37	0.49	0.61	0.39	0.49	1.00	0.43	0.36	0.45	1.00	0.39	0.39	0.41	0.38	0.42	0.39	0.36	0.47	0.54	0.34	0.60	0.35	0.46	0.48	0.34	0.47	0.43	0.43
864 (RUNX3)	0.60	0.45	0.62	0.72	0.41	0.76	0.39	0.56	0.58	0.54	0.78	0.61	0.44	0.41	0.54	0.74	1.00	0.55	0.46	0.53	0.50	0.74	0.71	0.46	0.60	0.61	0.57	0.70	0.43	1.00	0.57	0.81	0.43	0.53	0.46	0.61	0.51	0.50	0.56	0.38	0.80	0.53	0.55	0.81	0.35	0.45	1.00	0.48	0.63	0.80	0.74
1857 (DVL3)	0.71	0.66	0.76	0.53	0.64	0.63	0.64	0.81	0.57	0.56	0.55	0.56	0.49	0.58	0.57	0.61	1.00	0.56	0.69	0.71	0.67	0.51	0.52	0.72	0.72	0.54	0.81	0.50	0.36	0.57	1.00	0.62	0.36	0.65	0.69	0.52	0.71	0.73	0.69	0.63	0.64	0.59	0.70	0.63	0.62	0.52	1.00	0.63	0.73	0.52	0.70
2353 (FOS)	0.66	0.52	0.62	0.85	0.48	0.83	0.47	0.57	0.66	0.61	0.87	0.71	0.56	0.47	0.49	0.82	1.00	0.64	0.53	0.60	0.55	0.81	0.77	0.52	0.69	0.72	0.58	0.79	0.45	0.81	0.62	1.00	0.45	0.54	0.53	0.72	0.54	0.54	0.59	0.47	0.85	0.67	0.56	0.78	0.41	0.53	1.00	0.53	0.73	0.81	0.68
255626 (HIST1H2BA)	0.35	0.46	0.36	0.46	0.36	0.46	0.38	0.40	0.38	0.40	0.50	0.41	0.36	0.33	0.32	0.44	0.48	0.46	0.39	0.39	0.58	0.43	0.49	0.37	0.49	0.61	0.39	0.49	1.00	0.43	0.36	0.45	1.00	0.39	0.39	0.41	0.38	0.42	0.39	0.36	0.47	0.54	0.34	0.60	0.35	0.46	0.48	0.34	0.47	0.43	0.43
3728 (JUP)	0.80	0.56	0.72	0.57	0.56	0.60	0.65	0.65	0.63	0.56	0.52	0.56	0.54	0.64	0.53	0.55	1.00	0.53	0.67	0.70	0.70	0.51	0.51	0.60	0.67	0.50	0.67	0.57	0.39	0.53	0.65	0.54	0.39	1.00	0.67	0.57	0.61	0.62	0.67	0.56	0.56	0.54	0.62	0.56	0.61	0.53	1.00	0.62	0.69	0.58	0.59
7089 (TLE2)	0.72	0.54	0.70	0.50	0.54	0.58	0.75	0.73	0.64	0.59	0.53	0.61	0.46	0.64	0.50	0.53	1.00	0.51	1.00	0.96	0.93	0.46	0.46	0.66	0.82	0.44	0.72	0.51	0.39	0.46	0.69	0.53	0.39	0.67	1.00	0.53	0.63	0.68	0.87	0.52	0.55	0.52	0.64	0.53	0.72	0.46	1.00	0.69	0.84	0.51	0.62
1387 (CREBBP)	0.70	0.52	0.56	0.74	0.49	0.73	0.51	0.51	0.66	0.56	0.74	0.68	0.79	0.73	0.50	0.74	1.00	0.64	0.53	0.59	0.56	0.71	0.68	0.46	0.60	0.58	0.52	0.69	0.41	0.61	0.52	0.72	0.41	0.57	0.53	1.00	0.53	0.51	0.59	0.46	0.66	0.60	0.52	0.63	0.46	0.55	1.00	0.57	0.65	0.70	0.55
6500 (SKP1)	0.66	0.91	0.72	0.47	0.91	0.60	0.58	0.74	0.53	0.53	0.51	0.54	0.52	0.59	0.59	0.54	1.00	0.53	0.63	0.66	0.64	0.46	0.50	0.65	0.67	0.48	0.70	0.47	0.38	0.51	0.71	0.54	0.38	0.61	0.63	0.53	1.00	0.66	0.67	0.64	0.59	0.56	0.66	0.56	0.57	0.55	1.00	0.61	0.72	0.46	0.62
1488 (CTBP2)	0.72	0.58	0.78	0.47	0.59	0.66	0.59	0.79	0.53	0.51	0.56	0.53	0.45	0.52	0.52	0.56	1.00	0.54	0.68	0.71	0.65	0.48	0.49	0.72	0.68	0.49	0.76	0.46	0.42	0.50	0.73	0.54	0.42	0.62	0.68	0.51	0.66	1.00	0.68	0.58	0.57	0.59	0.73	0.57	0.56	0.48	1.00	0.64	0.70	0.44	0.68
1487 (CTBP1)	0.75	0.60	0.71	0.55	0.59	0.63	0.72	0.71	0.67	0.62	0.59	0.65	0.53	0.65	0.60	0.58	1.00	0.57	0.87	0.89	0.84	0.53	0.51	0.67	0.78	0.52	0.71	0.55	0.39	0.56	0.69	0.59	0.39	0.67	0.87	0.59	0.67	0.68	1.00	0.59	0.62	0.57	0.65	0.59	0.64	0.53	1.00	0.71	0.87	0.56	0.64
23043 (TNIK)	0.63	0.56	0.66	0.43	0.56	0.52	0.45	0.64	0.48	0.44	0.44	0.49	0.44	0.49	0.78	0.49	1.00	0.47	0.52	0.60	0.55	0.38	0.43	0.54	0.57	0.38	0.65	0.41	0.36	0.38	0.63	0.47	0.36	0.56	0.52	0.46	0.64	0.58	0.59	1.00	0.48	0.49	0.59	0.44	0.41	0.53	1.00	0.75	0.62	0.34	0.50
64321 (SOX17)	0.65	0.55	0.66	0.79	0.49	0.84	0.48	0.64	0.58	0.56	0.86	0.65	0.50	0.48	0.49	0.81	1.00	0.58	0.55	0.63	0.59	0.80	0.78	0.54	0.71	0.59	0.62	0.74	0.47	0.80	0.64	0.85	0.47	0.56	0.55	0.66	0.59	0.57	0.62	0.48	1.00	0.62	0.61	0.85	0.48	0.52	1.00	0.54	0.75	0.80	0.84
4221 (MEN1)	0.65	0.58	0.63	0.63	0.51	0.71	0.49	0.58	0.59	0.57	0.66	0.64	0.56	0.48	0.48	0.66	1.00	0.64	0.52	0.56	0.53	0.60	0.66	0.53	0.71	0.68	0.59	0.65	0.54	0.53	0.59	0.67	0.54	0.54	0.52	0.60	0.56	0.59	0.57	0.49	0.62	1.00	0.57	0.62	0.42	0.61	1.00	0.52	0.70	0.53	0.51
324 (APC)	0.68	0.62	0.80	0.56	0.65	0.65	0.60	0.78	0.55	0.57	0.54	0.55	0.48	0.55	0.59	0.57	1.00	0.55	0.64	0.69	0.64	0.51	0.53	0.66	0.67	0.53	0.72	0.52	0.34	0.55	0.70	0.56	0.34	0.62	0.64	0.52	0.66	0.73	0.65	0.59	0.61	0.57	1.00	0.59	0.56	0.53	1.00	0.70	0.69	0.51	0.64
9580 (SOX13)	0.63	0.53	0.65	0.73	0.47	0.80	0.45	0.63	0.54	0.52	0.82	0.57	0.46	0.45	0.45	0.76	1.00	0.58	0.53	0.59	0.57	0.75	0.74	0.54	0.64	0.61	0.64	0.74	0.60	0.81	0.63	0.78	0.60	0.56	0.53	0.63	0.56	0.57	0.59	0.44	0.85	0.62	0.59	1.00	0.41	0.55	1.00	0.51	0.67	0.78	0.86
283149 (BCL9L)	0.62	0.50	0.61	0.43	0.43	0.48	0.68	0.69	0.54	0.49	0.38	0.45	0.42	0.55	0.39	0.44	0.82	0.39	0.72	0.70	0.66	0.37	0.38	0.54	0.72	0.34	0.60	0.42	0.35	0.35	0.62	0.41	0.35	0.61	0.72	0.46	0.57	0.56	0.64	0.41	0.48	0.42	0.56	0.41	1.00	0.37	0.82	0.53	0.71	0.49	0.50
7015 (TERT)	0.57	0.62	0.59	0.60	0.52	0.59	0.45	0.50	0.52	0.52	0.56	0.57	0.58	0.49	0.54	0.57	1.00	0.62	0.46	0.52	0.49	0.48	0.57	0.46	0.57	0.58	0.54	0.59	0.46	0.45	0.52	0.53	0.46	0.53	0.46	0.55	0.55	0.48	0.53	0.53	0.52	0.61	0.53	0.55	0.37	1.00	1.00	0.55	0.59	0.45	0.45
607 (BCL9)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.48	1.00	1.00	1.00	0.48	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00
595 (CCND1)	0.72	0.57	0.70	0.55	0.58	0.59	0.62	0.67	0.62	0.56	0.52	0.64	0.52	0.59	0.71	0.56	1.00	0.57	0.69	0.73	0.70	0.48	0.49	0.57	0.68	0.46	0.62	0.50	0.34	0.48	0.63	0.53	0.34	0.62	0.69	0.57	0.61	0.64	0.71	0.75	0.54	0.52	0.70	0.51	0.53	0.55	1.00	1.00	0.71	0.50	0.55
6907 (TBL1X)	0.75	0.67	0.74	0.67	0.62	0.74	0.74	0.76	0.75	0.71	0.68	0.75	0.59	0.67	0.60	0.68	1.00	0.64	0.84	0.86	0.81	0.65	0.67	0.69	0.95	0.69	0.73	0.68	0.47	0.63	0.73	0.73	0.47	0.69	0.84	0.65	0.72	0.70	0.87	0.62	0.75	0.70	0.69	0.67	0.71	0.59	1.00	0.71	1.00	0.68	0.67
6659 (SOX4)	0.63	0.41	0.57	0.79	0.37	0.78	0.48	0.49	0.68	0.57	0.83	0.66	0.51	0.49	0.39	0.78	1.00	0.56	0.51	0.56	0.55	0.81	0.73	0.40	0.66	0.60	0.51	0.81	0.43	0.80	0.52	0.81	0.43	0.58	0.51	0.70	0.46	0.44	0.56	0.34	0.80	0.53	0.51	0.78	0.49	0.45	1.00	0.50	0.68	1.00	0.67
26959 (HBP1)	0.66	0.53	0.70	0.62	0.52	0.68	0.51	0.74	0.50	0.46	0.71	0.50	0.41	0.48	0.47	0.68	1.00	0.48	0.62	0.67	0.62	0.65	0.59	0.66	0.64	0.41	0.73	0.58	0.43	0.74	0.70	0.68	0.43	0.59	0.62	0.55	0.62	0.68	0.64	0.50	0.84	0.51	0.64	0.86	0.50	0.45	1.00	0.55	0.67	0.67	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
TCF7L2	Toad	Brain	-	3464 m	33 day	upregulated	3.058707169	RNA-seq	Tibetan Plateau	Asiatic toad	1	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	28673260

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
TCF4	6925	TCF7L2	6934	proximal_filtered	22955619	TRANSFAC
TCF7L2	6934	ACVRL1	94	Activation	19797053	TRUSST
TCF7L2	6934	BIRC5	332	Activation	10733571	TRUSST
TCF7L2	6934	CTNNB1	1499	Activation	16628196	TRUSST
TCF7L2	6934	GATA3	2625	Unknown	11057875	TRUSST
TCF7L2	6934	ABCB1	5243	Activation	19757157	TRUSST
TCF7L2	6934	PTGS2	5743	Activation	19247725	TRUSST
TCF7L2	6934	STAT3	6774	Repression	17344317	TRUSST
TCF7L2	6934	SNAI2	6591	Unknown	11847120	TRUSST
AR	367	TCF7L2	6934	Repression	21406724	TRUSST
FOXA2	3170	TCF7L2	6934	Unknown	9880562	TRUSST
GATA3	2625	TCF7L2	6934	Unknown	18583706	TRUSST
HNF4A	3172	TCF7L2	6934	Unknown	18583706	TRUSST
TP53	7157	TCF7L2	6934	Activation	21072196	TRUSST
TCF7L2	6934	HECA	51696	Unknown	10772892	TRUSST
TCF7L2	6934	GLCE	26035	Repression	21606196	TRUSST
TCF7L2	6934	STARD7	56910	Unknown	21184844	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT043052	hsa-miR-324-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT043583	hsa-miR-148b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT261338	hsa-miR-4698	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT261354	hsa-miR-3613-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT261349	hsa-miR-3606-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT261341	hsa-miR-8063	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT261342	hsa-miR-513a-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT261347	hsa-miR-513c-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT505417	hsa-miR-4793-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505423	hsa-miR-509-3-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505426	hsa-miR-193a-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505414	hsa-miR-485-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505415	hsa-miR-539-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505430	hsa-miR-200b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505418	hsa-miR-3919	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505427	hsa-miR-193b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505429	hsa-miR-200c-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505423	hsa-miR-509-3-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505428	hsa-miR-429	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505429	hsa-miR-200c-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505421	hsa-miR-217	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505422	hsa-miR-509-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505428	hsa-miR-429	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505412	hsa-miR-1298-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505425	hsa-miR-1-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505424	hsa-miR-4418	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505416	hsa-miR-3190-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505420	hsa-miR-6807-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505414	hsa-miR-485-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505418	hsa-miR-3919	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505419	hsa-miR-892b	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505421	hsa-miR-217	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505411	hsa-miR-4435	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505411	hsa-miR-4435	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505415	hsa-miR-539-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505424	hsa-miR-4418	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505427	hsa-miR-193b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505420	hsa-miR-6807-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505430	hsa-miR-200b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505413	hsa-miR-539-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505413	hsa-miR-539-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505422	hsa-miR-509-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505425	hsa-miR-1-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505412	hsa-miR-1298-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505416	hsa-miR-3190-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT505419	hsa-miR-892b	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT505426	hsa-miR-193a-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT553714	hsa-miR-454-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553694	hsa-miR-373-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553700	hsa-miR-519c-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553717	hsa-miR-130a-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553711	hsa-miR-301b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553703	hsa-miR-17-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553706	hsa-miR-20b-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553709	hsa-miR-93-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553713	hsa-miR-3666	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553690	hsa-miR-651-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553696	hsa-miR-5193	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553693	hsa-miR-616-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553695	hsa-miR-371b-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553699	hsa-miR-3169	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553715	hsa-miR-4295	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553716	hsa-miR-130b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553708	hsa-miR-526b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553698	hsa-miR-4759	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553704	hsa-miR-106b-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553691	hsa-miR-3117-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553697	hsa-miR-8083	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553701	hsa-miR-519b-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553710	hsa-miR-106a-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553712	hsa-miR-301a-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553692	hsa-miR-891b	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553702	hsa-miR-519a-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553705	hsa-miR-20a-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT553707	hsa-miR-519d-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT612388	hsa-miR-384	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT612391	hsa-miR-32-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT612390	hsa-miR-155-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT612389	hsa-miR-3685	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT621859	hsa-miR-421	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT621862	hsa-miR-505-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT621858	hsa-miR-1305	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT621861	hsa-miR-8485	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT621860	hsa-miR-7159-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641836	hsa-miR-623	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641841	hsa-miR-6768-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641842	hsa-miR-211-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641834	hsa-miR-5006-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641835	hsa-miR-4755-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641839	hsa-miR-4717-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641843	hsa-miR-204-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641837	hsa-miR-6832-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641838	hsa-miR-3938	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT641840	hsa-miR-4753-5p	Homo sapiens	TCF7L2	6934	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT733096	hsa-miR-26a-1-3p	Homo sapiens	TCF7L2	6934	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	25961460

Gene Ontology

ID	GO ID	GO Term	GO Type
6934	GO:0006357	regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
6934	GO:0048660	regulation of smooth muscle cell proliferation	GOTERM_BP_DIRECT
6934	GO:0000790	nuclear chromatin	GOTERM_CC_DIRECT
6934	GO:0043570	maintenance of DNA repeat elements	GOTERM_BP_DIRECT
6934	GO:0044212	transcription regulatory region DNA binding	GOTERM_MF_DIRECT
6934	GO:0005654	nucleoplasm	GOTERM_CC_DIRECT
6934	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
6934	GO:0032350	regulation of hormone metabolic process	GOTERM_BP_DIRECT
6934	GO:0060070	canonical Wnt signaling pathway	GOTERM_BP_DIRECT
6934	GO:0043565	sequence-specific DNA binding	GOTERM_MF_DIRECT
6934	GO:0070016	C-rich strand telomeric DNA binding	GOTERM_MF_DIRECT
6934	GO:0016605	PML body	GOTERM_CC_DIRECT
6934	GO:0031016	pancreas development	GOTERM_BP_DIRECT
6934	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
6934	GO:0006351	transcription	GOTERM_BP_DIRECT
6934	GO:0045892	negative regulation of transcription	GOTERM_BP_DIRECT
6934	GO:0001103	RNA polymerase II activating transcription factor binding	GOTERM_MF_DIRECT
6934	GO:0003700	transcription factor activity	GOTERM_MF_DIRECT
6934	GO:0035257	nuclear hormone receptor binding	GOTERM_MF_DIRECT
6934	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	GOTERM_BP_DIRECT
6934	GO:0045444	fat cell differentiation	GOTERM_BP_DIRECT
6934	GO:0051897	positive regulation of protein kinase B signaling	GOTERM_BP_DIRECT
6934	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	GOTERM_MF_DIRECT
6934	GO:0007050	cell cycle arrest	GOTERM_BP_DIRECT
6934	GO:0007223	Wnt signaling pathway	GOTERM_BP_DIRECT
6934	GO:0005515	protein binding	GOTERM_MF_DIRECT
6934	GO:0032993	protein-DNA complex	GOTERM_CC_DIRECT
6934	GO:0070369	beta-catenin-TCF7L2 complex	GOTERM_CC_DIRECT
6934	GO:0048625	myoblast fate commitment	GOTERM_BP_DIRECT
6934	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
6934	GO:0001568	blood vessel development	GOTERM_BP_DIRECT
6934	GO:0042593	glucose homeostasis	GOTERM_BP_DIRECT
6934	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	GOTERM_BP_DIRECT
6934	GO:0008134	transcription factor binding	GOTERM_MF_DIRECT
6934	GO:0009749	response to glucose	GOTERM_BP_DIRECT
6934	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	GOTERM_BP_DIRECT
6934	GO:0005634	nucleus	GOTERM_CC_DIRECT
6934	GO:0046827	positive regulation of protein export from nucleus	GOTERM_BP_DIRECT
6934	GO:0090090	negative regulation of canonical Wnt signaling pathway	GOTERM_BP_DIRECT
6934	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GOTERM_BP_DIRECT
6934	GO:0019901	protein kinase binding	GOTERM_MF_DIRECT
6934	GO:0016055	Wnt signaling pathway	GOTERM_BP_DIRECT
6934	GO:0032092	positive regulation of protein binding	GOTERM_BP_DIRECT
6934	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	GOTERM_BP_DIRECT
6934	GO:0008283	cell proliferation	GOTERM_BP_DIRECT
6934	GO:0032024	positive regulation of insulin secretion	GOTERM_BP_DIRECT
6934	GO:1904837	beta-catenin-TCF complex assembly	GOTERM_BP_DIRECT
6934	GO:0008013	beta-catenin binding	GOTERM_MF_DIRECT
6934	GO:0045295	glutathione dehydrogenase	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
6934	hsa04310	Wnt signaling pathway
6934	hsa04520	Adherens junction
6934	hsa04390	Hippo signaling pathway
6934	hsa04916	Melanogenesis
6934	hsa05216	Thyroid cancer
6934	hsa05215	Prostate cancer
6934	hsa05213	Endometrial cancer
6934	hsa05200	Pathways in cancer
6934	hsa05210	Colorectal cancer
6934	hsa05217	Basal cell carcinoma
6934	hsa05221	Acute myeloid leukemia
6934	hsa05412	Arrhythmogenic right ventricular cardiomyopathy

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
TCF7L2	6934	Juvenile-Onset Still Disease	C0087031	Disease or Syndrome	0.3	0.538	0.621	disease
TCF7L2	6934	Adenocarcinoma, Basal Cell	C0205641	Neoplastic Process	0.3	0.538	0.621	disease
TCF7L2	6934	Diabetes Mellitus, Non-Insulin-Dependent	C0011860	Disease or Syndrome	0.7	0.538	0.621	disease
TCF7L2	6934	Juvenile psoriatic arthritis	C3714758	Disease or Syndrome	0.3	0.538	0.621	disease
TCF7L2	6934	Colonic Neoplasms	C0009375	Neoplastic Process	0.33	0.538	0.621	group
TCF7L2	6934	Colorectal Carcinoma	C0009402	Neoplastic Process	0.4	0.538	0.621	disease
TCF7L2	6934	Adenocarcinoma, Tubular	C0205645	Neoplastic Process	0.3	0.538	0.621	disease
TCF7L2	6934	Juvenile arthritis	C3495559	Disease or Syndrome	0.3	0.538	0.621	disease
TCF7L2	6934	Hyperplasia	C0020507	Pathologic Function	0.3	0.538	0.621	phenotype
TCF7L2	6934	Adenocarcinoma, Oxyphilic	C0205642	Neoplastic Process	0.3	0.538	0.621	disease
TCF7L2	6934	Malignant tumor of colon	C0007102	Neoplastic Process	0.4	0.538	0.621	disease
TCF7L2	6934	Neurodevelopmental Disorders	C1535926	Mental or Behavioral Dysfunction	0.31	0.538	0.621	group
TCF7L2	6934	Coronary heart disease	C0010068	Disease or Syndrome	0.45	0.538	0.621	disease
TCF7L2	6934	Colorectal Neoplasms	C0009404	Neoplastic Process	0.4	0.538	0.621	group
TCF7L2	6934	Carcinoma, Cribriform	C0205643	Neoplastic Process	0.3	0.538	0.621	disease
TCF7L2	6934	Adenocarcinoma	C0001418	Neoplastic Process	0.31	0.538	0.621	group
TCF7L2	6934	Carcinoma, Granular Cell	C0205644	Neoplastic Process	0.3	0.538	0.621	disease
TCF7L2	6934	Colorectal Cancer	C1527249	Neoplastic Process	0.7	0.538	0.621	disease
TCF7L2	6934	Bipolar Disorder	C0005586	Mental or Behavioral Dysfunction	0.42	0.538	0.621	disease
TCF7L2	6934	Schizoaffective Disorder	C0036337	Mental or Behavioral Dysfunction	0.31	0.538	0.621	disease
TCF7L2	6934	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.34	0.538	0.621	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types