Nitric oxide synthase

AltitudeomicsDB
Protein Official symbol NOS3
Aliases NOS3
Chromosomal Location  7
Length 1203
Uniprot ID P29474
EC number 1.14.13.39
Protein family Information(Pfam) PF00667;PF00258;PF00175;PF02898;
PDB id 1M9J;1M9K;1M9M;1M9Q;1M9R;1NIW;2LL7;2MG5;2N8J;3EAH;3NOS;4D1O;4D1P;5UO8;5UO9;5UOA;5UOB;5UOC;5VVB;5VVC;5VVD;5XOF;6AV6;6AV7;6CIE;6CIF;6NH1;6NH2;6NH3;6NH4;6NH5;6NH6;6NH7;6NH8;6NHF;
InterPro ID IPR003097;IPR017927;IPR001094;IPR008254;IPR001709;IPR029039;IPR039261;IPR023173;IPR012144;IPR004030;IPR036119;IPR001433;IPR017938;
dbSNP rs3918166 rs1799983 rs145805216 rs145168353 rs7792133 rs3918232 rs3918201 rs3918234

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ASS1 OTC 0.999
ASS1 ASL 0.999
VEGFA KDR 0.998
AKT1 INS 0.996
AKT1 NOS3 0.996
PTPN11 GAB1 0.995
VEGFA HIF1A 0.994
BDKRB2 KNG1 0.993
VEGFA NOS3 0.993
CAV1 NOS3 0.991
CREB1 CAMK4 0.991
AKT1 HSP90AA1 0.991
JUN COPS5 0.99
AKT1 CREB1 0.99
GNB1 GNG2 0.988
CREB1 JUN 0.987
HSP90AA1 NOS3 0.987
AKT1 ESR1 0.986
CREB1 EP300 0.985
GNB1 GNAI2 0.984
NOS3 KNG1 0.983
ASL OTC 0.982
AKT1 HIF1A 0.982
NOS3 KDR 0.982
NOS3 ARG2 0.982
INS AKT2 0.981
AKT1 CAV1 0.98
AKT1 EDN1 0.98
VEGFA JUN 0.979
DNM2 CAV1 0.978
VEGFA ARNT 0.977
HSP90AB1 HSP90AA1 0.977
INS CAV1 0.976
ARG2 OTC 0.976
NOSTRIN NOS3 0.975
VEGFA KNG1 0.973
ESR1 NOS3 0.973
ARG1 OTC 0.973
INS PTPN11 0.972
AKT1 PTPN11 0.972
EDN1 KNG1 0.971
ARG1 ASL 0.971
NOSIP NOS3 0.969
HSP90AA1 KDR 0.969
HIF1A NOS3 0.969
CAV1 HSP90AA1 0.969
AZIN2 ARG2 0.968
GATM AZIN2 0.968
BDKRB2 NOS3 0.967
DNM2 WASL 0.965
JUN EP300 0.965
ESR2 NOS3 0.965
GNB1 GNAO1 0.964
ESR1 JUN 0.963
CREB1 EDN1 0.962
GATM ARG2 0.962
ESR1 HSP90AA1 0.961
AKT1 EP300 0.96
AKT1 ARNT 0.96
HIF1A EP300 0.96
VEGFA HSP90AA1 0.96
GNB1 GNAI3 0.959
HIF1A HSP90AA1 0.958
GNB1 GNAI1 0.958
ARG1 AZIN2 0.958
ESR1 EP300 0.956
EDN1 JUN 0.955
AKT1 GAB1 0.954
ASL ARG2 0.954
ARG1 NOS3 0.954
HIF1A JUN 0.954
VEGFA CREB1 0.954
INS PDPK1 0.953
HIF1A COPS5 0.953
GNB1 GNAZ 0.953
GNG2 GNAO1 0.953
ASS1 NOS3 0.952
JUN NOS3 0.952
VEGFA EP300 0.951
HSP90AB1 NOS3 0.951
ARNT EP300 0.951
VEGFA AKT1 0.951
CAV3 NOS3 0.95
PRKCD NOS3 0.95
DNM2 KDR 0.949
NOSTRIN DNM2 0.948
GATM ARG1 0.948
PTPN11 KDR 0.947
ASL NOS3 0.947
CREB1 NOS3 0.945
HIF1A EDN1 0.945
ASL AZIN2 0.944
VEGFA PTPN11 0.944
HIF1A CREB1 0.943
HSP90AA1 EP300 0.942
AKT2 HSP90AA1 0.941
NOSTRIN CAV1 0.941
EDN1 NOS3 0.941
HIF1A ARNT 0.94
CREB1 AKT2 0.94
ESR1 HSP90AB1 0.939
GNAI1 GNG2 0.938
HSP90AA1 AKT3 0.937
NOS3 SPR 0.936
NOS3 AZIN2 0.936
CREB1 AKT3 0.934
AKT2 NOS3 0.93
CREB1 PRKACA 0.93
EDN1 GNAI3 0.93
DNM2 NOS3 0.93
NOSTRIN WASL 0.929
PDPK1 HSP90AA1 0.929
BDKRB2 EDN1 0.929
AKT1 PDPK1 0.929
CREB1 ARNT 0.929
PDPK1 NOS3 0.928
NOS3 OTC 0.928
EDN1 EP300 0.928
GAB1 WASL 0.927
ZDHHC21 NOS3 0.927
AKT1 GNAI2 0.927
ESR2 HSP90AA1 0.926
NOS3 EP300 0.926
AKT2 PDPK1 0.925
GNG2 GNAI2 0.925
GNAZ GNG2 0.924
COPS5 EP300 0.924
GATM NOS3 0.924
LYPLA1 NOS3 0.923
NOS3 AKT3 0.923
PTPN11 NOS3 0.923
JUN ARNT 0.923
PDPK1 AKT3 0.923
CAV1 WASL 0.921
GNB1 AKT1 0.92
GNAI3 GNG2 0.92
CREB1 CAMK2B 0.92
VEGFA INS 0.919
ARNT NOS3 0.919
ARNT COPS5 0.918
VEGFA COPS5 0.918
AKT1 GNAI3 0.917
AKT1 GNG2 0.917
AKT1 GNAI1 0.917
EDN1 ARNT 0.917
VEGFA DNM2 0.916
EDN1 GNAI1 0.915
INS GNAI1 0.915
VEGFA GAB1 0.915
AKT1 GNAO1 0.915
ESR1 GNAO1 0.915
INS NOS3 0.914
KDR GAB1 0.914
GNAZ GNAO1 0.913
HSP90AA1 PRKACA 0.913
CAMK2B CAMK4 0.912
PRKCD PDPK1 0.91
AKT1 JUN 0.91
ESR1 ESR2 0.909
GNAZ PRKCD 0.909
CAMK2B CAV1 0.909
PRKCD GNG2 0.909
EDN1 GNAI2 0.909
EDN1 COPS5 0.908
GNG2 AKT3 0.908
CREB1 COPS5 0.908
PTPN11 PRKACA 0.908
EDN1 GNAO1 0.908
EDN1 GNG2 0.907
GNAI3 GAB1 0.907
GNAI1 PTPN11 0.907
GNAI1 GAB1 0.907
HSP90AB1 EP300 0.907
NOS3 CAMK4 0.907
GNAI1 GNAO1 0.906
HSP90AB1 ESR2 0.906
GNAI3 PTPN11 0.906
NOS3 GAB1 0.906
GNB1 AKT3 0.906
GATM ASL 0.905
GNB1 PDPK1 0.904
AKT1 SPR 0.904
ESR1 GNAI2 0.904
AKT2 AKT3 0.904
GNB1 NOS3 0.904
GNB1 PTPN11 0.904
AKT1 AKT2 0.904
GNAI3 GNAO1 0.903
GNB1 AKT2 0.903
HSP90AA1 SPR 0.903
GNAZ AKT1 0.903
BDKRB2 GNAI2 0.903
GNB1 ESR2 0.903
GNAI3 GNAI2 0.903
NOS3 GNAO1 0.902
GNB1 PRKCD 0.902
CAMK2B NOS3 0.902
GNAZ NOS3 0.902
COPS5 NOS3 0.902
GNAI3 NOS3 0.902
AKT1 AKT3 0.902
INS GNAI2 0.902
GNAI1 NOS3 0.902
GNAI2 NOS3 0.902
BDKRB2 GNAI3 0.901
VEGFA PRKACA 0.901
HSP90AA1 GAB1 0.901
GNAZ GNAI2 0.901
GNAI2 GNAO1 0.901
PRKACA KDR 0.901
ESR1 GNAI1 0.901
GNAZ GNAI3 0.901
NOS3 WASL 0.901
GNAI1 GNAI2 0.901
GNAZ GNAI1 0.901
GNB1 ESR1 0.901
GNAZ EDN1 0.901
ESR1 GNAI3 0.9
PRKACA GAB1 0.9
PRKACA NOS3 0.9
BDKRB2 GNG2 0.9
BDKRB2 GNAI1 0.9
ESR1 GNG2 0.9
GNG2 PRKACA 0.9
GNAZ ESR1 0.9
GNB1 BDKRB2 0.9
GNB1 EDN1 0.9
GNAI1 KNG1 0.9
PRKCD ARG1 0.9
GNB1 KNG1 0.9
GNG2 KNG1 0.9
GNAI2 KNG1 0.9
AKT2 GNG2 0.9
GNG2 NOS3 0.9
PTPN11 GNG2 0.9
GNAI3 KNG1 0.9
PDPK1 GNG2 0.9
GNAI3 GNAI1 0.9
ESR2 GNG2 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 445 (ASS1) 7422 (VEGFA) 207 (AKT1) 5781 (PTPN11) 624 (BDKRB2) 857 (CAV1) 1385 (CREB1) 3725 (JUN) 2782 (GNB1) 3320 (HSP90AA1) 4846 (NOS3) 435 (ASL) 3630 (INS) 1785 (DNM2) 3326 (HSP90AB1) 384 (ARG2) 115677 (NOSTRIN) 2099 (ESR1) 383 (ARG1) 1906 (EDN1) 51070 (NOSIP) 3091 (HIF1A) 113451 (AZIN2) 2628 (GATM) 2100 (ESR2) 54331 (GNG2) 405 (ARNT) 859 (CAV3) 5580 (PRKCD) 208 (AKT2) 2770 (GNAI1) 5170 (PDPK1) 2549 (GAB1) 340481 (ZDHHC21) 2781 (GNAZ) 10987 (COPS5) 10434 (LYPLA1) 2773 (GNAI3) 3791 (KDR) 816 (CAMK2B) 2771 (GNAI2) 5566 (PRKACA) 5009 (OTC) 3827 (KNG1) 814 (CAMK4) 2033 (EP300) 8976 (WASL) 2775 (GNAO1) 10000 (AKT3) 6697 (SPR)
445 (ASS1) 1.00 0.62 0.52 0.46 0.53 0.61 0.48 0.56 0.57 0.60 0.56 0.64 0.68 0.56 0.65 0.26 1.00 0.51 0.53 0.60 0.76 0.60 0.47 0.17 0.49 0.58 0.57 0.56 0.50 0.52 0.52 0.48 0.51 0.16 0.54 0.52 0.20 0.53 0.54 0.58 0.54 0.49 0.24 0.55 0.12 0.48 0.54 0.44 0.49 0.28
7422 (VEGFA) 0.62 1.00 0.58 0.53 0.61 0.66 0.53 0.56 0.60 0.59 0.52 0.64 0.67 0.60 0.62 0.22 1.00 0.54 0.59 0.65 0.61 0.62 0.56 0.12 0.53 0.61 0.61 0.60 0.56 0.58 0.58 0.55 0.57 0.12 0.60 0.53 0.14 0.59 0.59 0.64 0.60 0.55 0.21 0.70 0.09 0.48 0.60 0.50 0.56 0.19
207 (AKT1) 0.52 0.58 1.00 0.55 0.47 0.60 0.44 0.50 0.48 0.73 0.48 0.52 0.56 0.56 0.67 0.22 1.00 0.59 0.45 0.50 0.47 0.54 0.46 0.21 0.44 0.47 0.48 0.52 0.78 0.76 0.53 0.75 0.60 0.19 0.53 0.41 0.17 0.54 0.67 0.76 0.53 0.75 0.40 0.49 0.36 0.47 0.50 0.43 0.79 0.22
5781 (PTPN11) 0.46 0.53 0.55 1.00 0.51 0.56 0.39 0.42 0.47 0.55 0.41 0.47 0.58 0.48 0.55 0.23 1.00 0.53 0.46 0.49 0.44 0.54 0.39 0.17 0.39 0.47 0.44 0.49 0.61 0.50 0.45 0.54 0.73 0.16 0.47 0.41 0.30 0.45 0.56 0.55 0.47 0.61 0.25 0.44 0.22 0.43 0.44 0.39 0.53 0.18
624 (BDKRB2) 0.53 0.61 0.47 0.51 1.00 0.60 0.43 0.48 0.57 0.52 0.41 0.57 0.68 0.56 0.57 0.22 1.00 0.52 0.53 0.59 0.56 0.60 0.46 0.12 0.48 0.58 0.53 0.55 0.50 0.49 0.52 0.46 0.49 0.12 0.56 0.44 0.31 0.52 0.62 0.53 0.56 0.47 0.16 0.53 0.09 0.42 0.54 0.46 0.46 0.17
857 (CAV1) 0.61 0.66 0.60 0.56 0.60 1.00 0.56 0.57 0.62 0.63 0.50 0.63 0.69 0.63 0.66 0.21 1.00 0.62 0.59 0.65 0.61 0.66 0.60 0.13 0.57 0.61 0.57 0.76 0.67 0.58 0.57 0.59 0.57 0.12 0.59 0.53 0.15 0.58 0.58 0.62 0.59 0.59 0.21 0.63 0.09 0.49 0.63 0.47 0.56 0.20
1385 (CREB1) 0.48 0.53 0.44 0.39 0.43 0.56 1.00 0.89 0.44 0.52 0.38 0.46 0.52 0.45 0.56 0.16 1.00 0.73 0.40 0.46 0.47 0.80 0.37 0.11 0.78 0.43 0.78 0.48 0.44 0.39 0.41 0.39 0.40 0.11 0.42 0.44 0.13 0.41 0.45 0.46 0.42 0.41 0.16 0.42 0.08 0.54 0.41 0.33 0.38 0.17
3725 (JUN) 0.56 0.56 0.50 0.42 0.48 0.57 0.89 1.00 0.47 0.60 0.45 0.48 0.52 0.48 0.65 0.17 1.00 0.74 0.44 0.48 0.56 0.82 0.45 0.11 0.80 0.46 0.83 0.49 0.50 0.44 0.45 0.45 0.43 0.10 0.45 0.52 0.12 0.44 0.47 0.50 0.45 0.46 0.16 0.46 0.08 0.60 0.50 0.34 0.42 0.20
2782 (GNB1) 0.57 0.60 0.48 0.47 0.57 0.62 0.44 0.47 1.00 0.62 0.42 0.63 0.69 0.76 0.61 0.28 1.00 0.51 0.59 0.64 0.63 0.60 0.48 0.15 0.43 0.87 0.51 0.64 0.52 0.53 0.66 0.48 0.52 0.14 0.75 0.47 0.24 0.69 0.53 0.56 0.75 0.49 0.16 0.55 0.11 0.44 0.59 0.62 0.48 0.21
3320 (HSP90AA1) 0.60 0.59 0.73 0.55 0.52 0.63 0.52 0.60 0.62 1.00 0.55 0.55 0.58 0.66 0.89 0.20 1.00 0.59 0.52 0.54 0.59 0.62 0.51 0.13 0.53 0.60 0.56 0.55 0.67 0.63 0.63 0.59 0.55 0.12 0.64 0.52 0.16 0.64 0.61 0.63 0.64 0.65 0.27 0.53 0.15 0.50 0.54 0.50 0.64 0.24
4846 (NOS3) 0.56 0.52 0.48 0.41 0.41 0.50 0.38 0.45 0.42 0.55 1.00 0.43 0.48 0.49 0.55 0.32 1.00 0.44 0.47 0.44 0.46 0.50 0.37 0.16 0.41 0.42 0.45 0.45 0.43 0.45 0.52 0.40 0.39 0.15 0.48 0.40 0.20 0.48 0.43 0.43 0.48 0.42 0.36 0.48 0.12 0.45 0.40 0.41 0.45 0.52
435 (ASL) 0.64 0.64 0.52 0.47 0.57 0.63 0.46 0.48 0.63 0.55 0.43 1.00 0.75 0.59 0.60 0.26 1.00 0.50 0.59 0.67 0.67 0.59 0.54 0.18 0.44 0.66 0.52 0.59 0.52 0.55 0.52 0.49 0.55 0.17 0.57 0.45 0.20 0.53 0.57 0.62 0.57 0.50 0.20 0.57 0.13 0.43 0.61 0.46 0.50 0.23
3630 (INS) 0.68 0.67 0.56 0.58 0.68 0.69 0.52 0.52 0.69 0.58 0.48 0.75 1.00 0.67 0.62 0.23 1.00 0.53 0.66 0.77 0.73 0.63 0.59 0.13 0.51 0.71 0.58 0.63 0.58 0.64 0.60 0.56 0.62 0.12 0.66 0.53 0.14 0.62 0.64 0.67 0.66 0.56 0.16 0.68 0.09 0.46 0.69 0.54 0.59 0.20
1785 (DNM2) 0.56 0.60 0.56 0.48 0.56 0.63 0.45 0.48 0.76 0.66 0.49 0.59 0.67 1.00 0.68 0.24 1.00 0.50 0.56 0.61 0.59 0.62 0.47 0.13 0.45 0.78 0.51 0.56 0.54 0.65 0.81 0.48 0.51 0.12 0.86 0.47 0.20 0.86 0.52 0.54 0.86 0.50 0.16 0.55 0.09 0.43 0.59 0.71 0.60 0.23
3326 (HSP90AB1) 0.65 0.62 0.67 0.55 0.57 0.66 0.56 0.65 0.61 0.89 0.55 0.60 0.62 0.68 1.00 0.21 1.00 0.61 0.56 0.58 0.65 0.67 0.56 0.11 0.57 0.62 0.61 0.59 0.62 0.62 0.64 0.55 0.55 0.11 0.65 0.57 0.15 0.65 0.57 0.61 0.65 0.59 0.16 0.57 0.08 0.51 0.59 0.49 0.60 0.21
384 (ARG2) 0.26 0.22 0.22 0.23 0.22 0.21 0.16 0.17 0.28 0.20 0.32 0.26 0.23 0.24 0.21 1.00 0.32 0.18 0.86 0.21 0.25 0.20 0.20 0.17 0.17 0.28 0.19 0.23 0.20 0.22 0.30 0.21 0.21 0.16 0.24 0.26 0.32 0.23 0.20 0.21 0.24 0.20 0.20 0.37 0.12 0.18 0.21 0.19 0.22 0.18
115677 (NOSTRIN) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.32 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.16 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.16 1.00 1.00 0.18 1.00 1.00 1.00 1.00 1.00 0.16 1.00 0.12 1.00 1.00 0.69 1.00 0.27
2099 (ESR1) 0.51 0.54 0.59 0.53 0.52 0.62 0.73 0.74 0.51 0.59 0.44 0.50 0.53 0.50 0.61 0.18 1.00 1.00 0.46 0.50 0.50 0.74 0.47 0.13 0.82 0.48 0.69 0.54 0.60 0.49 0.46 0.53 0.54 0.12 0.47 0.44 0.13 0.46 0.58 0.54 0.47 0.55 0.25 0.48 0.13 0.56 0.50 0.36 0.50 0.18
383 (ARG1) 0.53 0.59 0.45 0.46 0.53 0.59 0.40 0.44 0.59 0.52 0.47 0.59 0.66 0.56 0.56 0.86 1.00 0.46 1.00 0.61 0.57 0.57 0.42 0.17 0.39 0.61 0.48 0.55 0.48 0.46 0.55 0.44 0.47 0.16 0.54 0.45 0.30 0.50 0.50 0.52 0.54 0.46 0.20 0.61 0.12 0.41 0.53 0.44 0.43 0.21
1906 (EDN1) 0.60 0.65 0.50 0.49 0.59 0.65 0.46 0.48 0.64 0.54 0.44 0.67 0.77 0.61 0.58 0.21 1.00 0.50 0.61 1.00 0.68 0.60 0.53 0.12 0.45 0.66 0.54 0.60 0.53 0.58 0.58 0.51 0.57 0.11 0.64 0.48 0.14 0.59 0.56 0.59 0.64 0.52 0.16 0.65 0.09 0.44 0.63 0.56 0.53 0.19
51070 (NOSIP) 0.76 0.61 0.47 0.44 0.56 0.61 0.47 0.56 0.63 0.59 0.46 0.67 0.73 0.59 0.65 0.25 1.00 0.50 0.57 0.68 1.00 0.63 0.46 0.14 0.48 0.66 0.60 0.59 0.50 0.55 0.53 0.46 0.53 0.13 0.58 0.52 0.15 0.54 0.53 0.56 0.58 0.48 0.16 0.56 0.10 0.46 0.61 0.47 0.48 0.28
3091 (HIF1A) 0.60 0.62 0.54 0.54 0.60 0.66 0.80 0.82 0.60 0.62 0.50 0.59 0.63 0.62 0.67 0.20 1.00 0.74 0.57 0.60 0.63 1.00 0.54 0.12 0.73 0.59 0.86 0.59 0.60 0.56 0.55 0.54 0.55 0.12 0.57 0.53 0.14 0.55 0.57 0.57 0.57 0.60 0.16 0.57 0.09 0.56 0.58 0.43 0.54 0.20
113451 (AZIN2) 0.47 0.56 0.46 0.39 0.46 0.60 0.37 0.45 0.48 0.51 0.37 0.54 0.59 0.47 0.56 0.20 1.00 0.47 0.42 0.53 0.46 0.54 1.00 0.15 0.37 0.48 0.44 0.54 0.52 0.39 0.43 0.46 0.41 0.14 0.45 0.34 0.18 0.42 0.46 0.49 0.45 0.41 0.20 0.47 0.11 0.39 0.51 0.38 0.37 0.18
2628 (GATM) 0.17 0.12 0.21 0.17 0.12 0.13 0.11 0.11 0.15 0.13 0.16 0.18 0.13 0.13 0.11 0.17 0.16 0.13 0.17 0.12 0.14 0.12 0.15 1.00 0.11 0.15 0.12 0.15 0.21 0.21 0.11 0.27 0.21 0.32 0.13 0.16 0.22 0.12 0.17 0.20 0.13 0.22 0.54 0.12 0.25 0.17 0.13 0.11 0.24 0.18
2100 (ESR2) 0.49 0.53 0.44 0.39 0.48 0.57 0.78 0.80 0.43 0.53 0.41 0.44 0.51 0.45 0.57 0.17 1.00 0.82 0.39 0.45 0.48 0.73 0.37 0.11 1.00 0.42 0.71 0.47 0.44 0.39 0.42 0.39 0.39 0.11 0.42 0.47 0.13 0.41 0.54 0.45 0.42 0.40 0.16 0.42 0.08 0.53 0.41 0.33 0.38 0.20
54331 (GNG2) 0.58 0.61 0.47 0.47 0.58 0.61 0.43 0.46 0.87 0.60 0.42 0.66 0.71 0.78 0.62 0.28 1.00 0.48 0.61 0.66 0.66 0.59 0.48 0.15 0.42 1.00 0.51 0.59 0.51 0.54 0.67 0.48 0.53 0.14 0.78 0.47 0.25 0.72 0.53 0.56 0.78 0.49 0.16 0.56 0.11 0.42 0.61 0.63 0.48 0.20
405 (ARNT) 0.57 0.61 0.48 0.44 0.53 0.57 0.78 0.83 0.51 0.56 0.45 0.52 0.58 0.51 0.61 0.19 1.00 0.69 0.48 0.54 0.60 0.86 0.44 0.12 0.71 0.51 1.00 0.53 0.47 0.47 0.48 0.44 0.47 0.11 0.49 0.46 0.13 0.48 0.49 0.54 0.49 0.45 0.16 0.50 0.09 0.52 0.49 0.39 0.45 0.21
859 (CAV3) 0.56 0.60 0.52 0.49 0.55 0.76 0.48 0.49 0.64 0.55 0.45 0.59 0.63 0.56 0.59 0.23 1.00 0.54 0.55 0.60 0.59 0.59 0.54 0.15 0.47 0.59 0.53 1.00 0.56 0.54 0.53 0.52 0.54 0.14 0.56 0.48 0.17 0.53 0.54 0.59 0.56 0.51 0.21 0.56 0.11 0.48 0.60 0.43 0.51 0.20
5580 (PRKCD) 0.50 0.56 0.78 0.61 0.50 0.67 0.44 0.50 0.52 0.67 0.43 0.52 0.58 0.54 0.62 0.20 1.00 0.60 0.48 0.53 0.50 0.60 0.52 0.21 0.44 0.51 0.47 0.56 1.00 0.76 0.47 0.85 0.65 0.19 0.48 0.42 0.17 0.46 0.69 0.79 0.48 0.86 0.31 0.51 0.45 0.46 0.54 0.38 0.79 0.19
208 (AKT2) 0.52 0.58 0.76 0.50 0.49 0.58 0.39 0.44 0.53 0.63 0.45 0.55 0.64 0.65 0.62 0.22 1.00 0.49 0.46 0.58 0.55 0.56 0.39 0.21 0.39 0.54 0.47 0.54 0.76 1.00 0.63 0.73 0.63 0.19 0.65 0.36 0.16 0.66 0.64 0.75 0.65 0.78 0.27 0.50 0.55 0.43 0.49 0.54 0.98 0.25
2770 (GNAI1) 0.52 0.58 0.53 0.45 0.52 0.57 0.41 0.45 0.66 0.63 0.52 0.52 0.60 0.81 0.64 0.30 1.00 0.46 0.55 0.58 0.53 0.55 0.43 0.11 0.42 0.67 0.48 0.53 0.47 0.63 1.00 0.43 0.46 0.11 0.93 0.43 0.18 0.94 0.49 0.49 0.93 0.45 0.16 0.58 0.08 0.42 0.50 0.88 0.59 0.24
5170 (PDPK1) 0.48 0.55 0.75 0.54 0.46 0.59 0.39 0.45 0.48 0.59 0.40 0.49 0.56 0.48 0.55 0.21 1.00 0.53 0.44 0.51 0.46 0.54 0.46 0.27 0.39 0.48 0.44 0.52 0.85 0.73 0.43 1.00 0.64 0.25 0.45 0.37 0.20 0.42 0.65 0.77 0.45 0.78 0.40 0.46 0.54 0.46 0.49 0.38 0.76 0.20
2549 (GAB1) 0.51 0.57 0.60 0.73 0.49 0.57 0.40 0.43 0.52 0.55 0.39 0.55 0.62 0.51 0.55 0.21 1.00 0.54 0.47 0.57 0.53 0.55 0.41 0.21 0.39 0.53 0.47 0.54 0.65 0.63 0.46 0.64 1.00 0.20 0.49 0.37 0.16 0.45 0.62 0.65 0.49 0.66 0.25 0.48 0.36 0.43 0.50 0.40 0.65 0.19
340481 (ZDHHC21) 0.16 0.12 0.19 0.16 0.12 0.12 0.11 0.10 0.14 0.12 0.15 0.17 0.12 0.12 0.11 0.16 0.16 0.12 0.16 0.11 0.13 0.12 0.14 0.32 0.11 0.14 0.11 0.14 0.19 0.19 0.11 0.25 0.20 1.00 0.12 0.15 0.21 0.11 0.16 0.18 0.12 0.21 0.34 0.11 0.22 0.25 0.12 0.10 0.22 0.16
2781 (GNAZ) 0.54 0.60 0.53 0.47 0.56 0.59 0.42 0.45 0.75 0.64 0.48 0.57 0.66 0.86 0.65 0.24 1.00 0.47 0.54 0.64 0.58 0.57 0.45 0.13 0.42 0.78 0.49 0.56 0.48 0.65 0.93 0.45 0.49 0.12 1.00 0.45 0.21 0.99 0.51 0.52 1.00 0.46 0.16 0.55 0.09 0.42 0.55 0.91 0.59 0.23
10987 (COPS5) 0.52 0.53 0.41 0.41 0.44 0.53 0.44 0.52 0.47 0.52 0.40 0.45 0.53 0.47 0.57 0.26 1.00 0.44 0.45 0.48 0.52 0.53 0.34 0.16 0.47 0.47 0.46 0.48 0.42 0.36 0.43 0.37 0.37 0.15 0.45 1.00 0.28 0.43 0.43 0.44 0.45 0.39 0.20 0.41 0.11 0.47 0.40 0.38 0.35 0.21
10434 (LYPLA1) 0.20 0.14 0.17 0.30 0.31 0.15 0.13 0.12 0.24 0.16 0.20 0.20 0.14 0.20 0.15 0.32 0.18 0.13 0.30 0.14 0.15 0.14 0.18 0.22 0.13 0.25 0.13 0.17 0.17 0.16 0.18 0.20 0.16 0.21 0.21 0.28 1.00 0.19 0.15 0.16 0.21 0.17 0.24 0.14 0.16 0.15 0.15 0.18 0.17 0.20
2773 (GNAI3) 0.53 0.59 0.54 0.45 0.52 0.58 0.41 0.44 0.69 0.64 0.48 0.53 0.62 0.86 0.65 0.23 1.00 0.46 0.50 0.59 0.54 0.55 0.42 0.12 0.41 0.72 0.48 0.53 0.46 0.66 0.94 0.42 0.45 0.11 0.99 0.43 0.19 1.00 0.49 0.50 0.99 0.44 0.16 0.53 0.08 0.41 0.51 0.91 0.61 0.25
3791 (KDR) 0.54 0.59 0.67 0.56 0.62 0.58 0.45 0.47 0.53 0.61 0.43 0.57 0.64 0.52 0.57 0.20 1.00 0.58 0.50 0.56 0.53 0.57 0.46 0.17 0.54 0.53 0.49 0.54 0.69 0.64 0.49 0.65 0.62 0.16 0.51 0.43 0.15 0.49 1.00 0.70 0.51 0.70 0.27 0.51 0.29 0.46 0.52 0.41 0.68 0.18
816 (CAMK2B) 0.58 0.64 0.76 0.55 0.53 0.62 0.46 0.50 0.56 0.63 0.43 0.62 0.67 0.54 0.61 0.21 1.00 0.54 0.52 0.59 0.56 0.57 0.49 0.20 0.45 0.56 0.54 0.59 0.79 0.75 0.49 0.77 0.65 0.18 0.52 0.44 0.16 0.50 0.70 1.00 0.52 0.78 0.27 0.53 0.47 0.46 0.57 0.41 0.76 0.19
2771 (GNAI2) 0.54 0.60 0.53 0.47 0.56 0.59 0.42 0.45 0.75 0.64 0.48 0.57 0.66 0.86 0.65 0.24 1.00 0.47 0.54 0.64 0.58 0.57 0.45 0.13 0.42 0.78 0.49 0.56 0.48 0.65 0.93 0.45 0.49 0.12 1.00 0.45 0.21 0.99 0.51 0.52 1.00 0.46 0.16 0.55 0.09 0.42 0.55 0.91 0.59 0.23
5566 (PRKACA) 0.49 0.55 0.75 0.61 0.47 0.59 0.41 0.46 0.49 0.65 0.42 0.50 0.56 0.50 0.59 0.20 1.00 0.55 0.46 0.52 0.48 0.60 0.41 0.22 0.40 0.49 0.45 0.51 0.86 0.78 0.45 0.78 0.66 0.21 0.46 0.39 0.17 0.44 0.70 0.78 0.46 1.00 0.31 0.46 0.51 0.46 0.46 0.37 0.81 0.19
5009 (OTC) 0.24 0.21 0.40 0.25 0.16 0.21 0.16 0.16 0.16 0.27 0.36 0.20 0.16 0.16 0.16 0.20 0.16 0.25 0.20 0.16 0.16 0.16 0.20 0.54 0.16 0.16 0.16 0.21 0.31 0.27 0.16 0.40 0.25 0.34 0.16 0.20 0.24 0.16 0.27 0.27 0.16 0.31 1.00 0.16 0.25 0.48 0.16 0.15 0.31 0.20
3827 (KNG1) 0.55 0.70 0.49 0.44 0.53 0.63 0.42 0.46 0.55 0.53 0.48 0.57 0.68 0.55 0.57 0.37 1.00 0.48 0.61 0.65 0.56 0.57 0.47 0.12 0.42 0.56 0.50 0.56 0.51 0.50 0.58 0.46 0.48 0.11 0.55 0.41 0.14 0.53 0.51 0.53 0.55 0.46 0.16 1.00 0.09 0.42 0.57 0.49 0.46 0.18
814 (CAMK4) 0.12 0.09 0.36 0.22 0.09 0.09 0.08 0.08 0.11 0.15 0.12 0.13 0.09 0.09 0.08 0.12 0.12 0.13 0.12 0.09 0.10 0.09 0.11 0.25 0.08 0.11 0.09 0.11 0.45 0.55 0.08 0.54 0.36 0.22 0.09 0.11 0.16 0.08 0.29 0.47 0.09 0.51 0.25 0.09 1.00 0.12 0.10 0.07 0.59 0.13
2033 (EP300) 0.48 0.48 0.47 0.43 0.42 0.49 0.54 0.60 0.44 0.50 0.45 0.43 0.46 0.43 0.51 0.18 1.00 0.56 0.41 0.44 0.46 0.56 0.39 0.17 0.53 0.42 0.52 0.48 0.46 0.43 0.42 0.46 0.43 0.25 0.42 0.47 0.15 0.41 0.46 0.46 0.42 0.46 0.48 0.42 0.12 1.00 0.41 0.34 0.43 0.19
8976 (WASL) 0.54 0.60 0.50 0.44 0.54 0.63 0.41 0.50 0.59 0.54 0.40 0.61 0.69 0.59 0.59 0.21 1.00 0.50 0.53 0.63 0.61 0.58 0.51 0.13 0.41 0.61 0.49 0.60 0.54 0.49 0.50 0.49 0.50 0.12 0.55 0.40 0.15 0.51 0.52 0.57 0.55 0.46 0.16 0.57 0.10 0.41 1.00 0.46 0.44 0.18
2775 (GNAO1) 0.44 0.50 0.43 0.39 0.46 0.47 0.33 0.34 0.62 0.50 0.41 0.46 0.54 0.71 0.49 0.19 0.69 0.36 0.44 0.56 0.47 0.43 0.38 0.11 0.33 0.63 0.39 0.43 0.38 0.54 0.88 0.38 0.40 0.10 0.91 0.38 0.18 0.91 0.41 0.41 0.91 0.37 0.15 0.49 0.07 0.34 0.46 1.00 0.51 0.20
10000 (AKT3) 0.49 0.56 0.79 0.53 0.46 0.56 0.38 0.42 0.48 0.64 0.45 0.50 0.59 0.60 0.60 0.22 1.00 0.50 0.43 0.53 0.48 0.54 0.37 0.24 0.38 0.48 0.45 0.51 0.79 0.98 0.59 0.76 0.65 0.22 0.59 0.35 0.17 0.61 0.68 0.76 0.59 0.81 0.31 0.46 0.59 0.43 0.44 0.51 1.00 0.25
6697 (SPR) 0.28 0.19 0.22 0.18 0.17 0.20 0.17 0.20 0.21 0.24 0.52 0.23 0.20 0.23 0.21 0.18 0.27 0.18 0.21 0.19 0.28 0.20 0.18 0.18 0.20 0.20 0.21 0.20 0.19 0.25 0.24 0.20 0.19 0.16 0.23 0.21 0.20 0.25 0.18 0.19 0.23 0.19 0.20 0.18 0.13 0.19 0.18 0.20 0.25 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
NOS3 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 3.3 RT-qPCR Western US C57BL/6 mice –12.8 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
NOS3 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 3.3 RT-qPCR Western US C57BL/6 mice –12.8 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
FOS 2353 NOS3 4846 distal 22955619 TRANSFAC
GATA2 2624 NOS3 4846 distal 22955619 TRANSFAC
CTCF 10664 NOS3 4846 distal 22955619 TRANSFAC
JUN 3725 NOS3 4846 distal 22955619 TRANSFAC
SIX5 147912 NOS3 4846 proximal_filtered 22955619 TRANSFAC
NFKB1 4790 NOS3 4846 Repression 21831840 TRUSST
SP3 6670 NOS3 4846 Unknown 8836133 TRUSST
SP1 6667 NOS3 4846 Unknown 8836133 TRUSST
DDIT3 1649 NOS3 4846 Activation 24628993 TRUSST
GATA4 2626 NOS3 4846 Activation 19651775 TRUSST
HDAC1 3065 NOS3 4846 Activation 15339794 TRUSST
ATF2 1386 NOS3 4846 Unknown 8633043 TRUSST
KLF2 10365 NOS3 4846 Repression 21831840 TRUSST
RELA 5970 NOS3 4846 Activation 19648825 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT007181 hsa-miR-155-5p Homo sapiens NOS3 4846 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 23108656
MIRT017773 hsa-miR-335-5p Homo sapiens NOS3 4846 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT053134 hsa-miR-24-3p Homo sapiens NOS3 4846 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 23774796
MIRT053134 hsa-miR-24-3p Homo sapiens NOS3 4846 Homo sapiens Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25920448
MIRT732952 hsa-miR-200c-3p Homo sapiens NOS3 4846 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27917915
MIRT735517 hsa-miR-335-3p Homo sapiens NOS3 4846 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 26647850
MIRT735516 hsa-miR-543 Homo sapiens NOS3 4846 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 26647850
Gene Ontology
ID GO ID GO Term GO Type
4846 GO:0007005 mitochondrion organization GOTERM_BP_DIRECT
4846 GO:0043542 endothelial cell migration GOTERM_BP_DIRECT
4846 GO:0045776 negative regulation of blood pressure GOTERM_BP_DIRECT
4846 GO:0005634 nucleus GOTERM_CC_DIRECT
4846 GO:0005829 cytosol GOTERM_CC_DIRECT
4846 GO:0003057 regulation of the force of heart contraction by chemical signal GOTERM_BP_DIRECT
4846 GO:0007263 nitric oxide mediated signal transduction GOTERM_BP_DIRECT
4846 GO:0014806 smooth muscle hyperplasia GOTERM_BP_DIRECT
4846 GO:0034405 response to fluid shear stress GOTERM_BP_DIRECT
4846 GO:0003100 regulation of systemic arterial blood pressure by endothelin GOTERM_BP_DIRECT
4846 GO:0030324 lung development GOTERM_BP_DIRECT
4846 GO:0051346 negative regulation of hydrolase activity GOTERM_BP_DIRECT
4846 GO:0005515 protein binding GOTERM_MF_DIRECT
4846 GO:0046870 polyamine oxidase activity GOTERM_MF_DIRECT
4846 GO:0005886 plasma membrane GOTERM_CC_DIRECT
4846 GO:0050880 regulation of blood vessel size GOTERM_BP_DIRECT
4846 GO:0050999 regulation of nitric-oxide synthase activity GOTERM_BP_DIRECT
4846 GO:0051926 negative regulation of calcium ion transport GOTERM_BP_DIRECT
4846 GO:0016491 oxidoreductase activity GOTERM_MF_DIRECT
4846 GO:0005901 caveola GOTERM_CC_DIRECT
4846 GO:0001701 in utero embryonic development GOTERM_BP_DIRECT
4846 GO:0001974 blood vessel remodeling GOTERM_BP_DIRECT
4846 GO:0005506 iron ion binding GOTERM_MF_DIRECT
4846 GO:0000139 Golgi membrane GOTERM_CC_DIRECT
4846 GO:0030666 endocytic vesicle membrane GOTERM_CC_DIRECT
4846 GO:0006809 nitric oxide biosynthetic process GOTERM_BP_DIRECT
4846 GO:0004517 monooxygenase activity GOTERM_MF_DIRECT
4846 GO:0005516 calmodulin binding GOTERM_MF_DIRECT
4846 GO:0050661 NADP binding GOTERM_MF_DIRECT
4846 GO:0097110 scaffold protein binding GOTERM_MF_DIRECT
4846 GO:0005856 cytoskeleton GOTERM_CC_DIRECT
4846 GO:0031663 lipopolysaccharide-mediated signaling pathway GOTERM_BP_DIRECT
4846 GO:0020037 heme binding GOTERM_MF_DIRECT
4846 GO:0006527 arginine catabolic process GOTERM_BP_DIRECT
4846 GO:0019430 removal of superoxide radicals GOTERM_BP_DIRECT
4846 GO:0050660 flavin adenine dinucleotide binding GOTERM_MF_DIRECT
4846 GO:0045454 cell redox homeostasis GOTERM_BP_DIRECT
4846 GO:0002028 regulation of sodium ion transport GOTERM_BP_DIRECT
4846 GO:0008217 regulation of blood pressure GOTERM_BP_DIRECT
4846 GO:0009408 response to heat GOTERM_BP_DIRECT
4846 GO:0014740 negative regulation of muscle hyperplasia GOTERM_BP_DIRECT
4846 GO:0031284 positive regulation of guanylate cyclase activity GOTERM_BP_DIRECT
4846 GO:0003785 actin monomer binding GOTERM_MF_DIRECT
4846 GO:0010181 pseudouridine synthase activity GOTERM_MF_DIRECT
4846 GO:0001542 ovulation from ovarian follicle GOTERM_BP_DIRECT
4846 GO:0045766 positive regulation of angiogenesis GOTERM_BP_DIRECT
4846 GO:0034617 protein kinase A regulatory subunit binding GOTERM_MF_DIRECT
4846 GO:0001525 angiogenesis GOTERM_BP_DIRECT
4846 GO:0045909 positive regulation of vasodilation GOTERM_BP_DIRECT
4846 GO:0034618 piRNA binding GOTERM_MF_DIRECT
4846 GO:0005737 cytoplasm GOTERM_CC_DIRECT
4846 GO:0008285 negative regulation of cell proliferation GOTERM_BP_DIRECT
4846 GO:0010544 negative regulation of platelet activation GOTERM_BP_DIRECT
4846 GO:0043267 negative regulation of potassium ion transport GOTERM_BP_DIRECT
4846 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
4846 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
4846 hsa00220 Arginine biosynthesis
4846 hsa00330 Arginine and proline metabolism
4846 hsa01100 Metabolic pathways
4846 hsa04022 cGMP-PKG signaling pathway
4846 hsa04020 Calcium signaling pathway
4846 hsa04066 HIF-1 signaling pathway
4846 hsa04071 Sphingolipid signaling pathway
4846 hsa04151 PI3K-Akt signaling pathway
4846 hsa04370 VEGF signaling pathway
4846 hsa04611 Platelet activation
4846 hsa04931 Insulin resistance
4846 hsa04921 Oxytocin signaling pathway
4846 hsa04915 Estrogen signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
NOS3 4846 Arteriosclerosis C0003850 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Esophageal Neoplasms C0014859 Neoplastic Process 0.3 0.401 0.862 group
NOS3 4846 Coronary Artery Vasospasm C0010073 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Diabetes Mellitus, Non-Insulin-Dependent C0011860 Disease or Syndrome 0.6 0.401 0.862 disease
NOS3 4846 Hypertension, Portal C0020541 Disease or Syndrome 0.51 0.401 0.862 disease
NOS3 4846 Pulmonary Hypertension C0020542 Pathologic Function 0.5 0.401 0.862 phenotype
NOS3 4846 Kidney Failure, Acute C0022660 Disease or Syndrome 0.5 0.401 0.862 disease
NOS3 4846 Chronic Obstructive Airway Disease C0024117 Disease or Syndrome 0.38 0.401 0.862 disease
NOS3 4846 Ureteral obstruction C0041956 Anatomical Abnormality 0.3 0.401 0.862 phenotype
NOS3 4846 Alzheimer Disease, Late Onset C0494463 Mental or Behavioral Dysfunction 0.33 0.401 0.862 disease
NOS3 4846 Hypoxemia C0700292 Finding 0.3 0.401 0.862 phenotype
NOS3 4846 Alzheimer Disease, Early Onset C0750901 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Cardiac Hypertrophy C1383860 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Malignant Neoplasms C0006826 Neoplastic Process 0.3 0.401 0.862 group
NOS3 4846 Heart failure C0018801 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Hyperlipidemia C0020473 Disease or Syndrome 0.52 0.401 0.862 disease
NOS3 4846 Carcinoma, Cribriform C0205643 Neoplastic Process 0.3 0.401 0.862 disease
NOS3 4846 Transient hypertension of pregnancy C0341934 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Coronary Artery Disease C1956346 Disease or Syndrome 0.5 0.401 0.862 disease
NOS3 4846 Anoxia C0003130 Pathologic Function 0.32 0.401 0.862 phenotype
NOS3 4846 Sepsis C0243026 Disease or Syndrome 0.33 0.401 0.862 disease
NOS3 4846 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.4 0.401 0.862 disease
NOS3 4846 Alzheimer's Disease, Focal Onset C0750900 Mental or Behavioral Dysfunction 0.3 0.401 0.862 disease
NOS3 4846 Cerebral Infarction, Left Hemisphere C0751010 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Atherogenesis C1563937 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Myocardial Failure C1959583 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Persistent atrial fibrillation C2585653 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Adenocarcinoma C0001418 Neoplastic Process 0.3 0.401 0.862 group
NOS3 4846 Anoxemia C0003129 Sign or Symptom 0.3 0.401 0.862 phenotype
NOS3 4846 Cerebral Infarction C0007785 Disease or Syndrome 0.35 0.401 0.862 disease
NOS3 4846 Hypoxia C0242184 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Posterior Choroidal Artery Infarction C0887799 Disease or Syndrome 0.3 0.401 0.862 phenotype
NOS3 4846 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.401 0.862 disease
NOS3 4846 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.401 0.862 disease
NOS3 4846 Pre-Eclampsia C0032914 Pathologic Function 0.38 0.401 0.862 phenotype
NOS3 4846 Necrotizing Enterocolitis C0520459 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Pregnancy associated hypertension C0852036 Disease or Syndrome 0.31 0.401 0.862 disease
NOS3 4846 Insulin Sensitivity C0920563 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 familial atrial fibrillation C3468561 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Malignant neoplasm of breast C0006142 Neoplastic Process 0.4 0.401 0.862 disease
NOS3 4846 Cruveilhier-Baumgarten Syndrome C0010398 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Diabetic Nephropathy C0011881 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Cardiomegaly C0018800 Finding 0.31 0.401 0.862 phenotype
NOS3 4846 Hyperglycemia C0020456 Disease or Syndrome 0.37 0.401 0.862 disease
NOS3 4846 Hyperinsulinism C0020459 Disease or Syndrome 0.32 0.401 0.862 disease
NOS3 4846 Paroxysmal atrial fibrillation C0235480 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Heart Failure, Right-Sided C0235527 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Endogenous Hyperinsulinism C1257963 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Atrial Fibrillation C0004238 Disease or Syndrome 0.35 0.401 0.862 disease
NOS3 4846 Diaphragmatic Hernia C0019284 Anatomical Abnormality 0.5 0.401 0.862 phenotype
NOS3 4846 Microangiopathy, Diabetic C0025945 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Premature ventricular contractions C0151636 Disease or Syndrome 0.3 0.401 0.862 phenotype
NOS3 4846 Myocardial Ischemia C0151744 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Adenocarcinoma, Tubular C0205645 Neoplastic Process 0.3 0.401 0.862 disease
NOS3 4846 Familial Alzheimer Disease (FAD) C0276496 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Metabolic Syndrome X C0524620 Disease or Syndrome 0.6 0.401 0.862 disease
NOS3 4846 Breast Carcinoma C0678222 Neoplastic Process 0.4 0.401 0.862 disease
NOS3 4846 Subcortical Infarction C0751014 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Exogenous Hyperinsulinism C1257964 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Chronic Airflow Obstruction C1527303 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Male infertility C0021364 Disease or Syndrome 0.37 0.401 0.862 disease
NOS3 4846 Left-Sided Heart Failure C0023212 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.31 0.401 0.862 disease
NOS3 4846 Benign Neoplasm C0086692 Neoplastic Process 0.3 0.401 0.862 group
NOS3 4846 Acute kidney injury C2609414 Injury or Poisoning 0.3 0.401 0.862 disease
NOS3 4846 Alzheimer's Disease C0002395 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Cardiovascular Diseases C0007222 Disease or Syndrome 0.4 0.401 0.862 group
NOS3 4846 Presenile dementia C0011265 Mental or Behavioral Dysfunction 0.31 0.401 0.862 disease
NOS3 4846 Stomach Neoplasms C0038356 Neoplastic Process 0.3 0.401 0.862 group
NOS3 4846 Streptozotocin Diabetes C0038433 Experimental Model of Disease 0.3 0.401 0.862 disease
NOS3 4846 Adenocarcinoma, Basal Cell C0205641 Neoplastic Process 0.3 0.401 0.862 disease
NOS3 4846 Acute Confusional Senile Dementia C0546126 Mental or Behavioral Dysfunction 0.3 0.401 0.862 disease
NOS3 4846 Malignant neoplasm of esophagus C0546837 Neoplastic Process 0.3 0.401 0.862 disease
NOS3 4846 Anterior Choroidal Artery Infarction C0751012 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Atherosclerosis C0004153 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Diabetes Mellitus, Experimental C0011853 Experimental Model of Disease 0.3 0.401 0.862 disease
NOS3 4846 Ischemia C0022116 Pathologic Function 0.31 0.401 0.862 phenotype
NOS3 4846 Myocardial Infarction C0027051 Disease or Syndrome 0.7 0.401 0.862 disease
NOS3 4846 Pyemia C0034189 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Uremia C0041948 Disease or Syndrome 0.31 0.401 0.862 disease
NOS3 4846 Subfertility, Male C0848676 Sign or Symptom 0.3 0.401 0.862 phenotype
NOS3 4846 Male sterility C0917731 Finding 0.3 0.401 0.862 phenotype
NOS3 4846 Cleft palate, isolated C1837218 Congenital Abnormality 0.3 0.401 0.862 disease
NOS3 4846 Heart Decompensation C1961112 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Hypertensive disease C0020538 Disease or Syndrome 0.6 0.401 0.862 group
NOS3 4846 Insulin Resistance C0021655 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Tachycardia, Ventricular C0042514 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Brittle diabetes C0342302 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Compensatory Hyperinsulinemia C1257965 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Mammary Neoplasms C1458155 Neoplastic Process 0.36 0.401 0.862 group
NOS3 4846 Diabetes Mellitus, Ketosis-Prone C3837958 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Cleft upper lip C0008924 Congenital Abnormality 0.3 0.401 0.862 disease
NOS3 4846 Coronary Arteriosclerosis C0010054 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Diabetic Angiopathies C0011875 Disease or Syndrome 0.53 0.401 0.862 disease
NOS3 4846 Hypertension, Goldblatt C0018036 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Hypertension, Renovascular C0020545 Disease or Syndrome 0.31 0.401 0.862 disease
NOS3 4846 Pulmonary Edema C0034063 Disease or Syndrome 0.52 0.401 0.862 disease
NOS3 4846 Essential Hypertension C0085580 Disease or Syndrome 0.6 0.401 0.862 disease
NOS3 4846 Cerebral Infarction, Right Hemisphere C0751011 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Lipidemias C1706412 Finding 0.3 0.401 0.862 phenotype
NOS3 4846 Myocardial Reperfusion Injury C0027055 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Prostatic Neoplasms C0033578 Neoplastic Process 0.35 0.401 0.862 group
NOS3 4846 Vestibular Diseases C0042594 Disease or Syndrome 0.3 0.401 0.862 group
NOS3 4846 Erectile dysfunction C0242350 Finding 0.6 0.401 0.862 disease
NOS3 4846 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.401 0.862 group
NOS3 4846 Abruptio Placentae C0000832 Pathologic Function 0.31 0.401 0.862 phenotype
NOS3 4846 Alloxan Diabetes C0002152 Experimental Model of Disease 0.3 0.401 0.862 disease
NOS3 4846 Cleft Palate C0008925 Congenital Abnormality 0.3 0.401 0.862 disease
NOS3 4846 Diabetes Mellitus, Insulin-Dependent C0011854 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Fetal Growth Retardation C0015934 Pathologic Function 0.3 0.401 0.862 phenotype
NOS3 4846 Nodular glomerulosclerosis C0017667 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Congestive heart failure C0018802 Disease or Syndrome 0.4 0.401 0.862 disease
NOS3 4846 Reperfusion Injury C0035126 Injury or Poisoning 0.31 0.401 0.862 disease
NOS3 4846 Septicemia C0036690 Disease or Syndrome 0.33 0.401 0.862 disease
NOS3 4846 Adenocarcinoma, Oxyphilic C0205642 Neoplastic Process 0.3 0.401 0.862 disease
NOS3 4846 Diabetes, Autoimmune C0205734 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Acute Kidney Insufficiency C1565662 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Severe Sepsis C1719672 Disease or Syndrome 0.31 0.401 0.862 disease
NOS3 4846 Intestinal Perforation C0021845 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Neoplasms C0027651 Neoplastic Process 0.3 0.401 0.862 group
NOS3 4846 Gastric ulcer C0038358 Disease or Syndrome 0.5 0.401 0.862 disease
NOS3 4846 Carcinoma, Granular Cell C0205644 Neoplastic Process 0.3 0.401 0.862 disease
NOS3 4846 Hyperglycemia, Postprandial C1855520 Finding 0.3 0.401 0.862 phenotype
NOS3 4846 Familial Ménière disease C4302111 Disease or Syndrome 0.3 0.401 0.862 disease
NOS3 4846 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.32 0.401 0.862 disease
NOS3 4846 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.32 0.401 0.862 disease
NOS3 4846 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.32 0.401 0.862 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
NOS3 4846 ENOS PLASMID None None None
NOS3 4846 ISOTHIOUREA THIOUREA CHEMBL260876 None
NOS3 4846 ORGANIC NITRATE + L-ARGININE None None None
NOS3 4846 TETRAHYDROBIOPTERIN SAPROPTERIN CHEMBL1201774 None
NOS3 4846 TETRAHYDROBIOPTERIN SAPROPTERIN CHEMBL1201774 None