ALTITUDEOMICSDB

Endothelin-1

AltitudeomicsDB

Protein Official symbol	EDN1
Aliases	EDN1
Chromosomal Location	6
Length	212
Uniprot ID	P05305
EC number	None
Protein family Information(Pfam)	PF00322;
PDB id	1EDN;1EDP;1T7H;1V6R;5GLH;6DK5;
InterPro ID	IPR020475;IPR019764;IPR001928;
dbSNP	rs587777233 rs587777232 rs587777231 rs6413478 rs5370

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
MAPK8	JUN	0.998
EGFR	EGF	0.997
EDN1	EDNRA	0.997
HRAS	EGFR	0.997
EDN1	EDNRB	0.996
CXCR4	CXCL12	0.996
AKT1	NOS3	0.996
JUN	MAPK1	0.994
JUN	MAPK3	0.992
NPS	TAC1	0.992
JUN	MAPK14	0.991
UTS2R	UTS2	0.991
TRH	GNRH1	0.99
SRC	EGF	0.99
EDN1	ECE1	0.99
AKT1	CREB1	0.99
TAC1	KNG1	0.988
TAC1	NTS	0.988
CREB1	JUN	0.987
AGTR1	AGT	0.987
NPS	OXT	0.986
HRAS	MAP2K1	0.986
CDC42	SRC	0.986
CDC42	MAPK8	0.985
TRH	OXT	0.985
TAC1	GRP	0.985
AKT1	RHOA	0.985
NPS	NTS	0.984
HRAS	SRC	0.983
CREB1	MAPK1	0.983
GRP	NTS	0.983
NOS3	KNG1	0.983
GNRH1	OXT	0.982
AKT1	HIF1A	0.982
AVP	OXT	0.982
HRAS	MAPK3	0.981
EDN1	AGT	0.981
AGTR2	AGT	0.981
CREB1	MAPK3	0.98
AKT1	EDN1	0.98
F2R	F2	0.98
HRAS	MAPK1	0.979
SRC	MMP9	0.979
RHOA	MAPK1	0.979
NPS	GNRH1	0.979
CREB1	MAPK14	0.978
NPS	GRP	0.978
RHOA	SRC	0.977
HRAS	EGF	0.977
NPS	TRH	0.976
RHOA	MAPK8	0.976
RHOA	EDN1	0.975
SRC	MMP2	0.974
HIF1A	EGFR	0.973
RHOA	MAPK3	0.972
EDN1	KNG1	0.971
KNG1	NTS	0.971
EDN1	SRC	0.971
TRH	NTS	0.97
EDN1	MAPK1	0.97
CDC42	EGFR	0.97
TAC1	TRH	0.97
EGF	KNG1	0.97
NPS	AVP	0.969
AGTR1	KNG1	0.969
HIF1A	NOS3	0.969
SRC	JUN	0.969
NPS	KNG1	0.969
ADRBK1	GNAQ	0.967
TAC1	OXT	0.967
ADRBK1	ADRB2	0.966
EDN1	MAPK14	0.966
CDC42	EGF	0.966
AVP	TRH	0.966
TRH	GRP	0.966
NTS	OXT	0.966
AGTR2	KNG1	0.966
RHOA	EGFR	0.965
CXCR4	EDN1	0.965
AGTR1	EDN1	0.965
CXCL12	MAPK1	0.965
AVP	EDN1	0.965
AGTR1	ADRBK1	0.965
KNG1	GRP	0.965
RHOA	EGF	0.964
EDN1	MAPK3	0.964
EDN1	GATA4	0.964
CXCR4	ADRBK1	0.963
TAC1	ADRA1B	0.963
ADRA1A	TAC1	0.963
EGF	SLC9A1	0.962
KNG1	OXT	0.962
CREB1	EDN1	0.962
ADRA1D	TAC1	0.962
AVP	GNRH1	0.962
AGT	MAPK3	0.962
F2	KNG1	0.961
CXCL12	MAPK3	0.961
SRC	F2	0.959
AGT	KNG1	0.959
EDN1	SLC9A3	0.959
AGT	F2	0.958
EDN1	UTS2	0.958
EGFR	SLC9A1	0.957
AVP	AGT	0.957
EDN1	TAC1	0.956
TAC1	GNRH1	0.956
F2	NTS	0.956
EDN1	EGF	0.956
ADRA1A	KNG1	0.955
EDN1	ADRA1B	0.955
ADRA1B	KNG1	0.955
AVP	GRP	0.955
AGT	EDNRA	0.955
EDN1	JUN	0.955
HIF1A	JUN	0.954
AVP	KNG1	0.954
ADRBK1	ADRA1B	0.954
ADRA1B	OXT	0.954
ADRA1D	KNG1	0.954
AKT1	SRC	0.954
ADRA1A	OXT	0.953
ADRA1D	OXT	0.953
GRP	OXT	0.953
TBXA2R	ADRA1B	0.953
MAPK8	EDN1	0.953
ADRA1A	ADRBK1	0.952
CDC42	MAPK14	0.952
ADRA1A	EDN1	0.952
AVP	TAC1	0.952
CXCL12	SRC	0.952
EDN1	ADRB2	0.952
JUN	NOS3	0.952
ADRA1D	EDN1	0.952
ADRA1D	ADRBK1	0.952
EDN1	MMP9	0.95
GNRH1	NTS	0.95
EDN1	AGTR2	0.95
EDN1	F2	0.95
EDNRB	KNG1	0.949
EDN1	EGFR	0.949
MAP2K1	MAPK3	0.948
EDN1	OXT	0.947
MAPK8	SRC	0.947
ADRA1D	GNAQ	0.947
ADRA1A	GNAQ	0.947
MAP2K1	MAPK1	0.947
HRAS	GNAQ	0.946
AVP	NTS	0.946
EDN1	MMP2	0.946
TBXA2R	ADRA1D	0.945
AVP	ADRA1D	0.945
CREB1	NOS3	0.945
NPS	ADRA1B	0.945
NPS	ADRA1D	0.945
AVP	ADRA1B	0.945
NPS	ADRB2	0.945
GNRH1	GRP	0.945
CXCR4	CDC42	0.945
HIF1A	EDN1	0.945
HIF1A	MAPK3	0.945
EDNRA	KNG1	0.945
CDC42	CXCL12	0.945
SRC	AGT	0.945
ADRA1A	AVP	0.945
NPS	ADRA1A	0.945
F2R	KNG1	0.944
EDNRB	GNAQ	0.944
EDNRA	GNRH1	0.944
EDN1	TRH	0.944
NPS	EDN1	0.944
HIF1A	CREB1	0.943
EDNRB	AGT	0.943
AVP	ADRB2	0.943
EDN1	UTS2R	0.943
CXCL12	EDN1	0.942
AGTR1	EGFR	0.942
F2R	MAPK3	0.942
EDN1	GRP	0.942
AGT	MAPK1	0.942
EDN1	MAP2K1	0.942
EDN1	NOS3	0.941
EDN1	ADRBK1	0.941
SRC	MAPK3	0.941
AVP	F2	0.941
TBXA2R	F2R	0.941
SRC	MAPK1	0.94
EDN1	F2R	0.94
F2	MAPK3	0.94
AGTR1	GNAQ	0.939
MAP2K1	MAPK14	0.939
TBXA2R	KNG1	0.939
TBXA2R	EDN1	0.939
HRAS	CXCL12	0.938
EDNRB	GNRH1	0.938
HRAS	MAPK8	0.938
TRH	KNG1	0.937
AGT	ADRB2	0.937
EDN1	GNRH1	0.937
AGTR1	EGF	0.937
AVP	EGF	0.937
TBXA2R	GNAQ	0.937
EGFR	MAPK3	0.937
EGFR	MAPK1	0.937
EDNRA	EGFR	0.936
SRC	MAP2K1	0.936
AKT1	EDNRA	0.936
AGTR1	AVP	0.935
EDNRB	TAC1	0.935
SRC	MAPK14	0.934
AVP	EDNRA	0.934
EDN1	NTS	0.933
AGTR1	TBXA2R	0.933
EDN1	SLC9A1	0.933
NTS	UTS2	0.933
AGT	NTS	0.933
NPS	UTS2	0.933
ADRA1B	TRH	0.932
ADRA1D	TRH	0.932
ADRA1B	NTS	0.932
AKT1	EGF	0.932
ADRA1A	NTS	0.932
EDNRA	GNAQ	0.932
HRAS	F2	0.932
ADRA1A	TRH	0.932
ADRA1D	NTS	0.932
HRAS	EDN1	0.932
CDC42	EDN1	0.931
AGTR1	F2	0.931
SRC	EGFR	0.931
F2	MAPK1	0.93
EDN1	GNAI3	0.93
EDN1	GNAQ	0.93
AKT1	CDC42	0.929
AGT	TAC1	0.929
AGTR1	TAC1	0.929
AVP	EDNRB	0.929
ADRA1B	GNAQ	0.929
EDNRB	SLC9A3	0.929
AGTR1	EDNRA	0.928
AGT	MAP2K1	0.928
EDNRA	ADRBK1	0.928
F2R	MAPK1	0.928
GNAQ	KNG1	0.928
CXCL12	MAP2K1	0.928
RHOA	CDC42	0.928
AGT	ADRA1B	0.927
NPS	ADRBK1	0.926
RHOA	EDNRA	0.926
F2R	GNAQ	0.926
HRAS	GNAI3	0.926
CXCR4	KNG1	0.926
F2	OXT	0.926
ADRB2	EGFR	0.926
ADRB2	EGF	0.926
TBXA2R	F2	0.925
AGTR1	ADRA1B	0.925
F2R	EDNRA	0.925
EDNRB	ADRBK1	0.925
AVP	UTS2R	0.925
EDNRB	GRP	0.925
CXCL12	KNG1	0.925
AGT	OXT	0.924
AGTR1	ADRA1D	0.924
CXCR4	F2	0.924
MAPK8	GNAQ	0.924
CXCL12	ADRBK1	0.924
ADRA1D	AGT	0.924
EDNRA	EGF	0.924
HRAS	RHOA	0.924
TRH	GNAQ	0.923
EDNRB	ADRA1B	0.923
AGT	TRH	0.923
ADRBK1	TRH	0.923
AGTR1	OXT	0.923
ADRBK1	KNG1	0.923
TAC1	EDNRA	0.923
GNAQ	MAPK14	0.922
NPS	AGT	0.922
NPS	EDNRB	0.922
NPS	EDNRA	0.921
AVP	EGFR	0.921
AGTR1	NTS	0.921
HRAS	AGT	0.921
TAC1	F2	0.921
ADRA1A	EDNRA	0.921
TAC1	ADRBK1	0.921
GNRH1	KNG1	0.921
AGT	ADRBK1	0.921
TBXA2R	EDNRA	0.921
CXCL12	F2	0.92
ADRA1D	EDNRB	0.92
AGTR1	ADRB2	0.92
ADRA1A	EDNRB	0.92
ADRA1D	EDNRA	0.92
AGTR1	EDNRB	0.92
ADRA1A	AGT	0.92
AGTR1	ADRA1A	0.92
AGTR2	NTS	0.92
ADRA1D	GRP	0.919
ADRA1D	UTS2R	0.919
MAPK8	MAPK3	0.919
ADRA1A	GRP	0.919
CXCL12	AGTR2	0.919
F2R	ADRBK1	0.919
GNAQ	GRP	0.919
EDNRA	ADRA1B	0.919
EDNRB	MAPK14	0.918
ADRA1B	GRP	0.918
MAPK8	MAPK1	0.918
EDNRA	GRP	0.918
AGTR2	ADRB2	0.918
CDC42	GNAI3	0.918
GNAI3	EGF	0.918
AGTR1	NPS	0.918
AGTR2	ADRA1B	0.918
EDNRB	AGTR2	0.917
TBXA2R	EDNRB	0.917
AGT	UTS2	0.917
AKT1	GNAI3	0.917
AGT	GNAQ	0.917
GNAI3	MAPK14	0.917
NPS	AGTR2	0.917
MAPK8	EDNRA	0.917
GNAQ	OXT	0.917
CXCR4	ADRB2	0.916
ADRBK1	F2	0.916
AGTR2	EDNRA	0.916
EDNRB	NTS	0.916
EDNRA	OXT	0.916
TRH	UTS2	0.916
AVP	ADRBK1	0.916
UTS2R	NTS	0.916
NPS	F2	0.915
CXCL12	ADRB2	0.915
AGTR1	TRH	0.915
AGTR1	AGTR2	0.915
ADRA1B	GNRH1	0.915
SLC9A1	MAPK14	0.915
CXCR4	GNAQ	0.915
F2	MAP2K1	0.915
GNAI3	MAPK1	0.914
SLC9A1	MAPK1	0.913
ADRA1D	GNRH1	0.913
GNAQ	GNRH1	0.913
NPS	UTS2R	0.913
TAC1	UTS2	0.913
AGTR2	F2	0.913
TBXA2R	AVP	0.913
ADRA1A	GNRH1	0.912
UTS2R	EDNRA	0.912
NPS	GNAQ	0.912
AGTR2	ADRBK1	0.912
F2	GNRH1	0.912
ADRA1D	ADRA1B	0.912
RHOA	GNAI3	0.912
F2R	GRP	0.912
EDNRB	OXT	0.912
GNAI3	MAPK3	0.912
GNRH1	UTS2	0.912
AVP	UTS2	0.912
F2R	TAC1	0.911
F2	UTS2	0.911
MAPK8	MAPK14	0.911
EDNRB	F2	0.911
TBXA2R	AGT	0.911
F2	ADRB2	0.91
UTS2R	KNG1	0.91
AGTR1	F2R	0.91
ADRA1B	ADRB2	0.91
TBXA2R	TAC1	0.91
CXCR4	GNAI3	0.91
TAC1	GNAQ	0.91
HRAS	F2R	0.91
F2R	NTS	0.91
AKT1	JUN	0.91
SRC	GNAI3	0.909
EDNRB	F2R	0.909
CXCR4	AGT	0.909
ADRA1A	UTS2	0.909
ADRBK1	NTS	0.909
F2R	GNRH1	0.908
TBXA2R	ADRA1A	0.908
ADRA1A	UTS2R	0.908
AGTR1	GNRH1	0.908
EDNRB	EDNRA	0.908
ADRA1D	F2	0.908
TBXA2R	ADRBK1	0.908
NPS	F2R	0.908
ADRA1D	F2R	0.908
ADRBK1	GNRH1	0.908
F2	GRP	0.908
OXT	UTS2	0.908
AGT	GNRH1	0.908
F2	TRH	0.908
MMP9	MMP2	0.908
UTS2R	ADRA1B	0.907
UTS2R	GNRH1	0.907
CXCL12	AGT	0.907
F2	ADRA1B	0.906
CDC42	EDNRA	0.906
GNAQ	NTS	0.906
ADRBK1	OXT	0.906
ADRA1B	UTS2	0.906
GNAI3	GNAQ	0.906
ADRA1A	ADRA1B	0.906
UTS2R	OXT	0.906
F2	GNAQ	0.906
CXCL12	GNAQ	0.906
CXCR4	AGTR2	0.906
EDNRA	SLC9A1	0.905
EDNRA	F2	0.905
CXCL12	GNAI3	0.905
ADRA1A	F2	0.905
EDNRA	NTS	0.905
GNAI3	EGFR	0.904
ADRA1D	UTS2	0.904
GNAQ	UTS2	0.904
F2R	TRH	0.904
EDNRA	TRH	0.904
UTS2R	TRH	0.904
EDNRB	TRH	0.904
AGT	UTS2R	0.904
AGTR1	GRP	0.903
AGTR2	UTS2R	0.903
AVP	GNAQ	0.903
TBXA2R	NTS	0.903
CXCR4	ADRA1B	0.903
CXCL12	ADRA1B	0.903
MAPK8	GNAI3	0.903
ADRBK1	GRP	0.902
AGTR2	GRP	0.902
UTS2R	F2R	0.902
ADRA1A	F2R	0.902
AGTR2	TRH	0.902
MAPK3	MAPK1	0.902
AGTR1	UTS2R	0.902
GNAI3	NOS3	0.902
F2R	ADRA1B	0.902
AGTR2	F2R	0.902
ADRA1A	ADRA1D	0.902
AGTR1	UTS2	0.902
EDNRB	GNAI3	0.902
KNG1	UTS2	0.902
EDNRB	UTS2R	0.902
EDNRA	UTS2	0.901
SLC9A1	MAPK3	0.901
GNAI3	F2R	0.901
TBXA2R	NPS	0.901
AGT	GRP	0.901
EDNRB	UTS2	0.901
AGT	F2R	0.901
GRP	UTS2	0.9
UTS2R	ADRBK1	0.9
F2R	UTS2	0.9
GNAI3	AGT	0.9
TBXA2R	UTS2R	0.9
GNAI3	KNG1	0.9
UTS2R	GRP	0.9
TBXA2R	TRH	0.9
TBXA2R	UTS2	0.9
AVP	F2R	0.9
UTS2R	F2	0.9
AGTR2	UTS2	0.9
F2R	OXT	0.9
AGTR2	GNAI3	0.9
TBXA2R	OXT	0.9
TBXA2R	GNRH1	0.9
TBXA2R	GRP	0.9
UTS2R	TAC1	0.9
ADRBK1	UTS2	0.9
UTS2R	GNAQ	0.9

Gene Ontology Semantic Similarity

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#	5599 (MAPK8)	1956 (EGFR)	1906 (EDN1)	3265 (HRAS)	7852 (CXCR4)	207 (AKT1)	3725 (JUN)	2837 (UTS2R)	7200 (TRH)	6714 (SRC)	6863 (TAC1)	1385 (CREB1)	185 (AGTR1)	998 (CDC42)	2922 (GRP)	4846 (NOS3)	2796 (GNRH1)	551 (AVP)	186 (AGTR2)	2149 (F2R)	387 (RHOA)	3091 (HIF1A)	3827 (KNG1)	1950 (EGF)	156 (ADRBK1)	4922 (NTS)	6387 (CXCL12)	148 (ADRA1A)	146 (ADRA1D)	183 (AGT)	2147 (F2)	147 (ADRA1B)	6915 (TBXA2R)	1910 (EDNRB)	5604 (MAP2K1)	1909 (EDNRA)	2776 (GNAQ)	154 (ADRB2)	2773 (GNAI3)	6548 (SLC9A1)	4318 (MMP9)	5595 (MAPK3)	5594 (MAPK1)	1432 (MAPK14)	10911 (UTS2)	1889 (ECE1)	4313 (MMP2)	2626 (GATA4)	6550 (SLC9A3)
5599 (MAPK8)	1.00	0.69	0.51	0.43	0.46	0.77	0.47	0.13	0.60	0.76	0.82	0.42	0.45	0.68	0.41	0.42	0.37	0.66	0.45	0.51	0.46	0.56	0.48	0.64	0.73	1.00	0.50	0.44	0.44	0.52	0.47	0.44	0.47	0.44	0.77	0.42	0.50	0.44	0.43	0.43	0.44	0.88	0.88	0.83	0.82	0.44	0.42	0.42	0.42
1956 (EGFR)	0.69	1.00	0.49	0.44	0.62	0.69	0.57	0.27	0.60	0.73	0.82	0.48	0.57	0.60	0.39	0.45	0.34	0.54	0.53	0.60	0.46	0.59	0.47	0.74	0.62	1.00	0.49	0.58	0.54	0.49	0.52	0.58	0.57	0.53	0.65	0.51	0.49	0.57	0.45	0.46	0.45	0.67	0.67	0.68	0.82	0.45	0.43	0.51	0.44
1906 (EDN1)	0.51	0.49	1.00	0.56	0.52	0.50	0.48	0.11	0.86	0.62	0.84	0.46	0.60	0.55	0.77	0.44	0.72	0.62	0.63	0.69	0.59	0.60	0.65	0.52	0.53	1.00	0.72	0.59	0.64	0.69	0.62	0.59	0.59	0.61	0.53	0.57	0.63	0.52	0.59	0.51	0.51	0.57	0.54	0.57	0.84	0.54	0.53	0.50	0.58
3265 (HRAS)	0.43	0.44	0.56	1.00	0.46	0.54	0.44	0.10	0.60	0.57	0.82	0.40	0.48	0.76	0.47	0.48	0.42	0.41	0.49	0.54	0.90	0.56	0.52	0.44	0.43	1.00	0.55	0.47	0.48	0.53	0.53	0.47	0.45	0.47	0.48	0.45	0.65	0.44	0.92	0.44	0.47	0.48	0.45	0.48	0.82	0.47	0.45	0.45	0.45
7852 (CXCR4)	0.46	0.62	0.52	0.46	1.00	0.45	0.46	0.48	0.60	0.53	0.82	0.42	0.68	0.47	0.42	0.42	0.37	0.39	0.68	0.76	0.50	0.56	0.47	0.59	0.44	1.00	0.52	0.68	0.68	0.50	0.61	0.68	0.61	0.69	0.47	0.67	0.48	0.61	0.46	0.45	0.44	0.48	0.46	0.50	0.82	0.45	0.43	0.44	0.46
207 (AKT1)	0.77	0.69	0.50	0.54	0.45	1.00	0.50	0.10	0.60	0.74	0.82	0.44	0.45	0.72	0.39	0.48	0.35	0.62	0.45	0.49	0.53	0.54	0.49	0.63	0.70	1.00	0.49	0.44	0.44	0.50	0.48	0.44	0.46	0.44	0.75	0.43	0.49	0.48	0.54	0.50	0.47	0.77	0.77	0.72	0.82	0.49	0.43	0.43	0.43
3725 (JUN)	0.47	0.57	0.48	0.44	0.46	0.50	1.00	0.10	0.60	0.54	0.82	0.89	0.47	0.48	0.38	0.45	0.33	0.38	0.45	0.47	0.46	0.82	0.46	0.44	0.43	1.00	0.47	0.46	0.44	0.48	0.45	0.46	0.44	0.44	0.46	0.43	0.51	0.47	0.44	0.44	0.44	0.47	0.46	0.48	0.82	0.46	0.42	0.87	0.44
2837 (UTS2R)	0.13	0.27	0.11	0.10	0.48	0.10	0.10	1.00	0.09	0.10	0.12	0.10	0.55	0.10	0.10	0.10	0.09	0.09	0.57	0.57	0.10	0.11	0.11	0.32	0.10	0.14	0.10	0.55	0.61	0.10	0.29	0.55	0.46	0.61	0.12	0.61	0.11	0.37	0.10	0.09	0.10	0.13	0.12	0.13	0.12	0.11	0.11	0.10	0.10
7200 (TRH)	0.60	0.60	0.86	0.60	0.60	0.60	0.60	0.09	1.00	0.73	0.73	0.60	0.60	0.60	0.73	0.60	0.86	0.73	0.60	0.73	0.60	0.60	0.73	0.60	0.60	0.60	0.73	0.60	0.60	0.86	0.73	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.73	0.60	0.60	0.60	0.60
6714 (SRC)	0.76	0.73	0.62	0.57	0.53	0.74	0.54	0.10	0.73	1.00	1.00	0.52	0.56	0.71	0.55	0.58	0.48	0.70	0.57	0.61	0.58	0.62	0.59	0.74	0.76	1.00	0.66	0.56	0.57	0.60	0.59	0.56	0.56	0.56	0.78	0.55	0.58	0.53	0.57	0.54	0.55	0.77	0.77	0.75	1.00	0.55	0.55	0.54	0.55
6863 (TAC1)	0.82	0.82	0.84	0.82	0.82	0.82	0.82	0.12	0.73	1.00	1.00	0.82	0.82	0.82	1.00	0.82	0.84	1.00	0.82	1.00	0.82	0.82	1.00	0.84	0.82	0.82	1.00	0.82	0.82	0.84	1.00	0.82	0.82	0.82	0.82	0.82	0.84	0.82	0.84	0.82	0.82	0.82	0.82	0.82	1.00	0.82	0.82	0.82	0.82
1385 (CREB1)	0.42	0.48	0.46	0.40	0.42	0.44	0.89	0.10	0.60	0.52	0.82	1.00	0.41	0.46	0.36	0.38	0.32	0.35	0.41	0.46	0.43	0.80	0.42	0.40	0.39	1.00	0.46	0.40	0.40	0.45	0.42	0.40	0.39	0.40	0.41	0.39	0.42	0.41	0.41	0.41	0.41	0.44	0.43	0.45	0.82	0.40	0.37	0.87	0.40
185 (AGTR1)	0.45	0.57	0.60	0.48	0.68	0.45	0.47	0.55	0.60	0.56	0.82	0.41	1.00	0.50	0.53	0.39	0.47	0.46	0.83	0.81	0.51	0.59	0.52	0.55	0.47	1.00	0.61	0.75	0.71	0.57	0.60	0.75	0.61	0.75	0.48	0.71	0.56	0.58	0.52	0.46	0.45	0.50	0.47	0.51	0.82	0.47	0.44	0.45	0.48
998 (CDC42)	0.68	0.60	0.55	0.76	0.47	0.72	0.48	0.10	0.60	0.71	0.82	0.46	0.50	1.00	0.47	0.49	0.41	0.55	0.51	0.55	0.78	0.60	0.52	0.56	0.66	1.00	0.55	0.49	0.51	0.53	0.53	0.49	0.49	0.50	0.68	0.48	0.61	0.47	0.74	0.46	0.51	0.71	0.72	0.69	0.82	0.50	0.49	0.46	0.49
2922 (GRP)	0.41	0.39	0.77	0.47	0.42	0.39	0.38	0.10	0.73	0.55	1.00	0.36	0.53	0.47	1.00	0.34	0.79	0.69	0.59	0.64	0.50	0.51	0.59	0.46	0.48	0.82	0.75	0.50	0.58	0.70	0.58	0.50	0.51	0.53	0.43	0.48	0.56	0.41	0.50	0.41	0.41	0.48	0.43	0.46	1.00	0.44	0.43	0.39	0.48
4846 (NOS3)	0.42	0.45	0.44	0.48	0.42	0.48	0.45	0.10	0.60	0.58	0.82	0.38	0.39	0.49	0.34	1.00	0.31	0.35	0.39	0.44	0.47	0.50	0.48	0.40	0.40	1.00	0.44	0.38	0.38	0.43	0.44	0.38	0.37	0.38	0.43	0.37	0.42	0.40	0.48	0.39	0.47	0.44	0.43	0.43	0.82	0.46	0.39	0.45	0.37
2796 (GNRH1)	0.37	0.34	0.72	0.42	0.37	0.35	0.33	0.09	0.86	0.48	0.84	0.32	0.47	0.41	0.79	0.31	1.00	0.58	0.52	0.56	0.45	0.45	0.53	0.41	0.43	0.69	0.64	0.45	0.52	0.66	0.52	0.45	0.46	0.48	0.39	0.45	0.49	0.37	0.44	0.37	0.37	0.43	0.39	0.41	0.84	0.40	0.40	0.35	0.44
551 (AVP)	0.66	0.54	0.62	0.41	0.39	0.62	0.38	0.09	0.73	0.70	1.00	0.35	0.46	0.55	0.69	0.35	0.58	1.00	0.48	0.54	0.43	0.48	0.65	0.59	0.72	0.82	0.62	0.42	0.45	0.69	0.52	0.42	0.44	0.43	0.69	0.41	0.53	0.39	0.46	0.38	0.40	0.67	0.68	0.62	1.00	0.41	0.39	0.37	0.41
186 (AGTR2)	0.45	0.53	0.63	0.49	0.68	0.45	0.45	0.57	0.60	0.57	0.82	0.41	0.83	0.51	0.59	0.39	0.52	0.48	1.00	0.82	0.52	0.58	0.54	0.55	0.45	1.00	0.62	0.68	0.73	0.58	0.60	0.68	0.62	0.74	0.48	0.69	0.54	0.56	0.49	0.46	0.45	0.51	0.47	0.51	0.82	0.47	0.43	0.45	0.49
2149 (F2R)	0.51	0.60	0.69	0.54	0.76	0.49	0.47	0.57	0.73	0.61	1.00	0.46	0.81	0.55	0.64	0.44	0.56	0.54	0.82	1.00	0.57	0.60	0.60	0.65	0.53	1.00	0.69	0.81	0.84	0.65	0.70	0.81	0.74	0.81	0.53	0.78	0.59	0.67	0.55	0.50	0.50	0.56	0.53	0.56	1.00	0.52	0.51	0.49	0.55
387 (RHOA)	0.46	0.46	0.59	0.90	0.50	0.53	0.46	0.10	0.60	0.58	0.82	0.43	0.51	0.78	0.50	0.47	0.45	0.43	0.52	0.57	1.00	0.61	0.53	0.46	0.46	1.00	0.58	0.50	0.53	0.56	0.54	0.50	0.49	0.51	0.48	0.49	0.68	0.46	0.86	0.46	0.49	0.51	0.47	0.54	0.82	0.50	0.49	0.46	0.49
3091 (HIF1A)	0.56	0.59	0.60	0.56	0.56	0.54	0.82	0.11	0.60	0.62	0.82	0.80	0.59	0.60	0.51	0.50	0.45	0.48	0.58	0.60	0.61	1.00	0.57	0.53	0.54	1.00	0.60	0.59	0.58	0.59	0.56	0.59	0.56	0.57	0.54	0.55	0.57	0.53	0.55	0.53	0.53	0.57	0.55	0.61	0.82	0.54	0.54	0.81	0.57
3827 (KNG1)	0.48	0.47	0.65	0.52	0.47	0.49	0.46	0.11	0.73	0.59	1.00	0.42	0.52	0.52	0.59	0.48	0.53	0.65	0.54	0.60	0.53	0.57	1.00	0.49	0.48	1.00	0.65	0.50	0.53	0.73	0.67	0.50	0.51	0.51	0.49	0.47	0.57	0.47	0.53	0.47	0.56	0.50	0.47	0.50	1.00	0.59	0.44	0.45	0.49
1950 (EGF)	0.64	0.74	0.52	0.44	0.59	0.63	0.44	0.32	0.60	0.74	0.84	0.40	0.55	0.56	0.46	0.40	0.41	0.59	0.55	0.65	0.46	0.53	0.49	1.00	0.64	1.00	0.53	0.56	0.55	0.55	0.57	0.56	0.61	0.53	0.71	0.51	0.50	0.53	0.44	0.43	0.43	0.64	0.65	0.62	0.84	0.43	0.41	0.43	0.43
156 (ADRBK1)	0.73	0.62	0.53	0.43	0.44	0.70	0.43	0.10	0.60	0.76	0.82	0.39	0.47	0.66	0.48	0.40	0.43	0.72	0.45	0.53	0.46	0.54	0.48	0.64	1.00	1.00	0.55	0.44	0.45	0.51	0.48	0.44	0.43	0.44	0.79	0.41	0.51	0.42	0.48	0.42	0.43	0.79	0.79	0.75	0.82	0.43	0.40	0.43	0.43
4922 (NTS)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.14	0.60	1.00	0.82	1.00	1.00	1.00	0.82	1.00	0.69	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00
6387 (CXCL12)	0.50	0.49	0.72	0.55	0.52	0.49	0.47	0.10	0.73	0.66	1.00	0.46	0.61	0.55	0.75	0.44	0.64	0.62	0.62	0.69	0.58	0.60	0.65	0.53	0.55	1.00	1.00	0.57	0.61	0.67	0.64	0.57	0.57	0.59	0.53	0.56	0.66	0.51	0.62	0.51	0.52	0.56	0.53	0.55	1.00	0.53	0.52	0.49	0.56
148 (ADRA1A)	0.44	0.58	0.59	0.47	0.68	0.44	0.46	0.55	0.60	0.56	0.82	0.40	0.75	0.49	0.50	0.38	0.45	0.42	0.68	0.81	0.50	0.59	0.50	0.56	0.44	1.00	0.57	1.00	0.92	0.55	0.59	1.00	0.63	0.69	0.47	0.65	0.50	0.69	0.47	0.45	0.44	0.49	0.46	0.50	0.82	0.45	0.42	0.44	0.47
146 (ADRA1D)	0.44	0.54	0.64	0.48	0.68	0.44	0.44	0.61	0.60	0.57	0.82	0.40	0.71	0.51	0.58	0.38	0.52	0.45	0.73	0.84	0.53	0.58	0.53	0.55	0.45	1.00	0.61	0.92	1.00	0.59	0.60	0.92	0.66	0.72	0.48	0.67	0.53	0.68	0.49	0.45	0.44	0.51	0.47	0.52	0.82	0.46	0.42	0.45	0.49
183 (AGT)	0.52	0.49	0.69	0.53	0.50	0.50	0.48	0.10	0.86	0.60	0.84	0.45	0.57	0.53	0.70	0.43	0.66	0.69	0.58	0.65	0.56	0.59	0.73	0.55	0.51	1.00	0.67	0.55	0.59	1.00	0.63	0.55	0.57	0.56	0.52	0.53	0.62	0.50	0.57	0.49	0.49	0.54	0.51	0.54	0.84	0.51	0.50	0.48	0.54
2147 (F2)	0.47	0.52	0.62	0.53	0.61	0.48	0.45	0.29	0.73	0.59	1.00	0.42	0.60	0.53	0.58	0.44	0.52	0.52	0.60	0.70	0.54	0.56	0.67	0.57	0.48	1.00	0.64	0.59	0.60	0.63	1.00	0.59	0.55	0.57	0.49	0.56	0.55	0.53	0.54	0.47	0.67	0.51	0.48	0.52	1.00	0.60	0.69	0.46	0.49
147 (ADRA1B)	0.44	0.58	0.59	0.47	0.68	0.44	0.46	0.55	0.60	0.56	0.82	0.40	0.75	0.49	0.50	0.38	0.45	0.42	0.68	0.81	0.50	0.59	0.50	0.56	0.44	1.00	0.57	1.00	0.92	0.55	0.59	1.00	0.63	0.69	0.47	0.65	0.50	0.69	0.47	0.45	0.44	0.49	0.46	0.50	0.82	0.45	0.42	0.44	0.47
6915 (TBXA2R)	0.47	0.57	0.59	0.45	0.61	0.46	0.44	0.46	0.60	0.56	0.82	0.39	0.61	0.49	0.51	0.37	0.46	0.44	0.62	0.74	0.49	0.56	0.51	0.61	0.43	1.00	0.57	0.63	0.66	0.57	0.55	0.63	1.00	0.61	0.47	0.57	0.53	0.57	0.46	0.44	0.43	0.48	0.44	0.49	0.82	0.44	0.40	0.44	0.46
1910 (EDNRB)	0.44	0.53	0.61	0.47	0.69	0.44	0.44	0.61	0.60	0.56	0.82	0.40	0.75	0.50	0.53	0.38	0.48	0.43	0.74	0.81	0.51	0.57	0.51	0.53	0.44	1.00	0.59	0.69	0.72	0.56	0.57	0.69	0.61	1.00	0.47	0.75	0.51	0.60	0.47	0.45	0.44	0.50	0.46	0.50	0.82	0.59	0.41	0.44	0.47
5604 (MAP2K1)	0.77	0.65	0.53	0.48	0.47	0.75	0.46	0.12	0.60	0.78	0.82	0.41	0.48	0.68	0.43	0.43	0.39	0.69	0.48	0.53	0.48	0.54	0.49	0.71	0.79	1.00	0.53	0.47	0.48	0.52	0.49	0.47	0.47	0.47	1.00	0.45	0.52	0.45	0.46	0.44	0.45	0.79	0.80	0.80	0.82	0.46	0.44	0.44	0.45
1909 (EDNRA)	0.42	0.51	0.57	0.45	0.67	0.43	0.43	0.61	0.60	0.55	0.82	0.39	0.71	0.48	0.48	0.37	0.45	0.41	0.69	0.78	0.49	0.55	0.47	0.51	0.41	1.00	0.56	0.65	0.67	0.53	0.56	0.65	0.57	0.75	0.45	1.00	0.49	0.54	0.45	0.43	0.45	0.47	0.44	0.48	0.82	0.45	0.42	0.43	0.43
2776 (GNAQ)	0.50	0.49	0.63	0.65	0.48	0.49	0.51	0.11	0.60	0.58	0.84	0.42	0.56	0.61	0.56	0.42	0.49	0.53	0.54	0.59	0.68	0.57	0.57	0.50	0.51	1.00	0.66	0.50	0.53	0.62	0.55	0.50	0.53	0.51	0.52	0.49	1.00	0.48	0.77	0.47	0.51	0.51	0.48	0.51	0.84	0.50	0.49	0.46	0.49
154 (ADRB2)	0.44	0.57	0.52	0.44	0.61	0.48	0.47	0.37	0.60	0.53	0.82	0.41	0.58	0.47	0.41	0.40	0.37	0.39	0.56	0.67	0.46	0.53	0.47	0.53	0.42	1.00	0.51	0.69	0.68	0.50	0.53	0.69	0.57	0.60	0.45	0.54	0.48	1.00	0.45	0.43	0.43	0.47	0.44	0.47	0.82	0.52	0.41	0.44	0.44
2773 (GNAI3)	0.43	0.45	0.59	0.92	0.46	0.54	0.44	0.10	0.60	0.57	0.84	0.41	0.52	0.74	0.50	0.48	0.44	0.46	0.49	0.55	0.86	0.55	0.53	0.44	0.48	1.00	0.62	0.47	0.49	0.57	0.54	0.47	0.46	0.47	0.46	0.45	0.77	0.45	1.00	0.45	0.49	0.48	0.45	0.48	0.84	0.47	0.46	0.45	0.46
6548 (SLC9A1)	0.43	0.46	0.51	0.44	0.45	0.50	0.44	0.09	0.60	0.54	0.82	0.41	0.46	0.46	0.41	0.39	0.37	0.38	0.46	0.50	0.46	0.53	0.47	0.43	0.42	1.00	0.51	0.45	0.45	0.49	0.47	0.45	0.44	0.45	0.44	0.43	0.47	0.43	0.45	1.00	0.42	0.47	0.45	0.49	0.82	0.43	0.41	0.43	0.82
4318 (MMP9)	0.44	0.45	0.51	0.47	0.44	0.47	0.44	0.10	0.60	0.55	0.82	0.41	0.45	0.51	0.41	0.47	0.37	0.40	0.45	0.50	0.49	0.53	0.56	0.43	0.43	1.00	0.52	0.44	0.44	0.49	0.67	0.44	0.43	0.44	0.45	0.45	0.51	0.43	0.49	0.42	1.00	0.50	0.48	0.46	0.82	0.86	0.88	0.43	0.43
5595 (MAPK3)	0.88	0.67	0.57	0.48	0.48	0.77	0.47	0.13	0.60	0.77	0.82	0.44	0.50	0.71	0.48	0.44	0.43	0.67	0.51	0.56	0.51	0.57	0.50	0.64	0.79	1.00	0.56	0.49	0.51	0.54	0.51	0.49	0.48	0.50	0.79	0.47	0.51	0.47	0.48	0.47	0.50	1.00	0.99	0.85	0.82	0.49	0.46	0.45	0.48
5594 (MAPK1)	0.88	0.67	0.54	0.45	0.46	0.77	0.46	0.12	0.60	0.77	0.82	0.43	0.47	0.72	0.43	0.43	0.39	0.68	0.47	0.53	0.47	0.55	0.47	0.65	0.79	1.00	0.53	0.46	0.47	0.51	0.48	0.46	0.44	0.46	0.80	0.44	0.48	0.44	0.45	0.45	0.48	0.99	1.00	0.85	0.82	0.47	0.44	0.43	0.44
1432 (MAPK14)	0.83	0.68	0.57	0.48	0.50	0.72	0.48	0.13	0.60	0.75	0.82	0.45	0.51	0.69	0.46	0.43	0.41	0.62	0.51	0.56	0.54	0.61	0.50	0.62	0.75	1.00	0.55	0.50	0.52	0.54	0.52	0.50	0.49	0.50	0.80	0.48	0.51	0.47	0.48	0.49	0.46	0.85	0.85	1.00	0.82	0.47	0.46	0.46	0.48
10911 (UTS2)	0.82	0.82	0.84	0.82	0.82	0.82	0.82	0.12	0.73	1.00	1.00	0.82	0.82	0.82	1.00	0.82	0.84	1.00	0.82	1.00	0.82	0.82	1.00	0.84	0.82	0.82	1.00	0.82	0.82	0.84	1.00	0.82	0.82	0.82	0.82	0.82	0.84	0.82	0.84	0.82	0.82	0.82	0.82	0.82	1.00	0.82	0.82	0.82	0.82
1889 (ECE1)	0.44	0.45	0.54	0.47	0.45	0.49	0.46	0.11	0.60	0.55	0.82	0.40	0.47	0.50	0.44	0.46	0.40	0.41	0.47	0.52	0.50	0.54	0.59	0.43	0.43	1.00	0.53	0.45	0.46	0.51	0.60	0.45	0.44	0.59	0.46	0.45	0.50	0.52	0.47	0.43	0.86	0.49	0.47	0.47	0.82	1.00	0.76	0.43	0.44
4313 (MMP2)	0.42	0.43	0.53	0.45	0.43	0.43	0.42	0.11	0.60	0.55	0.82	0.37	0.44	0.49	0.43	0.39	0.40	0.39	0.43	0.51	0.49	0.54	0.44	0.41	0.40	1.00	0.52	0.42	0.42	0.50	0.69	0.42	0.40	0.41	0.44	0.42	0.49	0.41	0.46	0.41	0.88	0.46	0.44	0.46	0.82	0.76	1.00	0.41	0.40
2626 (GATA4)	0.42	0.51	0.50	0.45	0.44	0.43	0.87	0.10	0.60	0.54	0.82	0.87	0.45	0.46	0.39	0.45	0.35	0.37	0.45	0.49	0.46	0.81	0.45	0.43	0.43	1.00	0.49	0.44	0.45	0.48	0.46	0.44	0.44	0.44	0.44	0.43	0.46	0.44	0.45	0.43	0.43	0.45	0.43	0.46	0.82	0.43	0.41	1.00	0.44
6550 (SLC9A3)	0.42	0.44	0.58	0.45	0.46	0.43	0.44	0.10	0.60	0.55	0.82	0.40	0.48	0.49	0.48	0.37	0.44	0.41	0.49	0.55	0.49	0.57	0.49	0.43	0.43	1.00	0.56	0.47	0.49	0.54	0.49	0.47	0.46	0.47	0.45	0.43	0.49	0.44	0.46	0.82	0.43	0.48	0.44	0.48	0.82	0.44	0.40	0.44	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
EDN1	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	7.2	RT-qPCR	Western US	C57BL/6 mice	–3.5	7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
EDN1	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	6.2	RT-qPCR	Western US	C57BL/6 mice	–3.5	7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
JUNB	3726	EDN1	1906	distal	22955619	TRANSFAC
YY1	7528	EDN1	1906	distal	22955619	TRANSFAC
STAT1	6772	EDN1	1906	distal	22955619	TRANSFAC
FOSL1	8061	EDN1	1906	distal	22955619	TRANSFAC
CCNT2	905	EDN1	1906	distal	22955619	TRANSFAC
CHD2	1106	EDN1	1906	distal	22955619	TRANSFAC
JUN	3725	EDN1	1906	distal	22955619	TRANSFAC
SMARCB1	6598	EDN1	1906	distal	22955619	TRANSFAC
MAX	4149	EDN1	1906	distal	22955619	TRANSFAC
HDAC2	3066	EDN1	1906	distal	22955619	TRANSFAC
TAL1	6886	EDN1	1906	distal	22955619	TRANSFAC
GATA2	2624	EDN1	1906	distal	22955619	TRANSFAC
HMGN3	9324	EDN1	1906	distal	22955619	TRANSFAC
MYC	4609	EDN1	1906	distal	22955619	TRANSFAC
MAFK	7975	EDN1	1906	distal	22955619	TRANSFAC
EP300	2033	EDN1	1906	distal	22955619	TRANSFAC
REST	5978	EDN1	1906	distal	22955619	TRANSFAC
SMARCA4	6597	EDN1	1906	distal	22955619	TRANSFAC
JUND	3727	EDN1	1906	distal	22955619	TRANSFAC
RAD21	5885	EDN1	1906	distal	22955619	TRANSFAC
SMC3	9126	EDN1	1906	distal	22955619	TRANSFAC
FOS	2353	EDN1	1906	distal	22955619	TRANSFAC
GATA3	2625	EDN1	1906	proximal_filtered	22955619	TRANSFAC
FOXA1	3169	EDN1	1906	proximal_filtered	22955619	TRANSFAC
ESR1	2099	EDN1	1906	proximal_filtered	22955619	TRANSFAC
CTCF	10664	EDN1	1906	proximal_filtered	22955619	TRANSFAC
RELA	5970	EDN1	1906	Unknown	11463853	TRUSST
FOXO1	2308	EDN1	1906	Unknown	2543297	TRUSST
HIF1A	3091	EDN1	1906	Unknown	14988427	TRUSST
NFKB1	4790	EDN1	1906	Unknown	14988427	TRUSST
NR1H4	9971	EDN1	1906	Activation	14684846	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT004455	hsa-miR-155-5p	Homo sapiens	EDN1	1906	Homo sapiens	Luciferase reporter assay	Functional MTI	19783678
MIRT005432	hsa-miR-199a-5p	Homo sapiens	EDN1	1906	Homo sapiens	Luciferase reporter assay	Functional MTI	19783678
MIRT006855	hsa-miR-1-3p	Homo sapiens	EDN1	1906	Homo sapiens	Luciferase reporter assay	Functional MTI	22963810
MIRT006855	hsa-miR-1-3p	Homo sapiens	EDN1	1906	Homo sapiens	Luciferase reporter assay//qRT-PCR	Functional MTI	25394359
MIRT006855	hsa-miR-1-3p	Homo sapiens	EDN1	1906	Homo sapiens	Luciferase reporter assay//qRT-PCR	Functional MTI	28042875
MIRT006855	hsa-miR-1-3p	Homo sapiens	EDN1	1906	Homo sapiens	Microarray	Functional MTI (Weak)	18668037
MIRT006855	hsa-miR-1-3p	Homo sapiens	EDN1	1906	Homo sapiens	Microarray//ELISA//qRT-PCR	Functional MTI (Weak)	24394957
MIRT006855	hsa-miR-1-3p	Homo sapiens	EDN1	1906	Homo sapiens	ELISA//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	28493075
MIRT022267	hsa-miR-124-3p	Homo sapiens	EDN1	1906	Homo sapiens	Microarray	Functional MTI (Weak)	18668037
MIRT244068	hsa-let-7d-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244080	hsa-miR-759	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244066	hsa-let-7b-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244073	hsa-miR-98-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244078	hsa-miR-130b-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244089	hsa-miR-4710	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244075	hsa-let-7i-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244087	hsa-miR-4458	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244077	hsa-miR-301a-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244085	hsa-miR-3666	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244088	hsa-miR-4500	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244074	hsa-let-7g-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244079	hsa-miR-454-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244082	hsa-miR-1294	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244069	hsa-let-7e-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244081	hsa-miR-301b-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244090	hsa-miR-6800-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244067	hsa-let-7c-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244070	hsa-let-7f-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244076	hsa-miR-130a-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244065	hsa-let-7a-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244073	hsa-miR-98-5p	Homo sapiens	EDN1	1906	Homo sapiens	Luciferase reporter assay	Functional MTI	26098770
MIRT244083	hsa-miR-4295	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244086	hsa-miR-3927-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT244091	hsa-miR-6831-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT378368	hsa-miR-6738-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT378367	hsa-miR-4727-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477747	hsa-miR-379-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477742	hsa-miR-8060	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477744	hsa-miR-664a-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477736	hsa-miR-5001-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477735	hsa-miR-670-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477741	hsa-miR-4769-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477738	hsa-miR-7154-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477739	hsa-miR-202-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477740	hsa-miR-6817-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477743	hsa-miR-1279	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477737	hsa-miR-433-3p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477746	hsa-miR-3529-5p	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT477745	hsa-miR-6074	Homo sapiens	EDN1	1906	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT615478	hsa-miR-557	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615477	hsa-miR-3680-3p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615482	hsa-miR-33a-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615486	hsa-miR-19b-2-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615481	hsa-miR-33b-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615485	hsa-miR-520d-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615488	hsa-miR-19a-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615480	hsa-miR-450b-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615479	hsa-miR-507	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615487	hsa-miR-19b-1-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615484	hsa-miR-524-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615489	hsa-miR-4328	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615483	hsa-miR-1298-5p	Homo sapiens	EDN1	1906	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT732169	hsa-miR-125a-5p	Homo sapiens	EDN1	1906	Homo sapiens	Luciferase reporter assay	Functional MTI	27106952
MIRT732477	hsa-miR-648	Homo sapiens	EDN1	1906	Homo sapiens	qRT-PCR//Luciferase reporter assa//Northern blot//Western blot	Functional MTI	25403488

Gene Ontology

ID	GO ID	GO Term	GO Type
1906	GO:0019233	sensory perception of pain	GOTERM_BP_DIRECT
1906	GO:0033574	response to testosterone	GOTERM_BP_DIRECT
1906	GO:0007585	respiratory gaseous exchange	GOTERM_BP_DIRECT
1906	GO:0014823	response to activity	GOTERM_BP_DIRECT
1906	GO:0030818	negative regulation of cAMP biosynthetic process	GOTERM_BP_DIRECT
1906	GO:0014824	artery smooth muscle contraction	GOTERM_BP_DIRECT
1906	GO:0019229	regulation of vasoconstriction	GOTERM_BP_DIRECT
1906	GO:0019722	calcium-mediated signaling	GOTERM_BP_DIRECT
1906	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
1906	GO:0007589	body fluid secretion	GOTERM_BP_DIRECT
1906	GO:0010613	positive regulation of cardiac muscle hypertrophy	GOTERM_BP_DIRECT
1906	GO:0030185	nitric oxide transport	GOTERM_BP_DIRECT
1906	GO:0007166	cell surface receptor signaling pathway	GOTERM_BP_DIRECT
1906	GO:0007267	cell-cell signaling	GOTERM_BP_DIRECT
1906	GO:0010193	response to ozone	GOTERM_BP_DIRECT
1906	GO:0015758	glucose transport	GOTERM_BP_DIRECT
1906	GO:0030072	peptide hormone secretion	GOTERM_BP_DIRECT
1906	GO:0035810	positive regulation of urine volume	GOTERM_BP_DIRECT
1906	GO:0010595	positive regulation of endothelial cell migration	GOTERM_BP_DIRECT
1906	GO:0014826	vein smooth muscle contraction	GOTERM_BP_DIRECT
1906	GO:0032269	negative regulation of cellular protein metabolic process	GOTERM_BP_DIRECT
1906	GO:0034696	response to prostaglandin F	GOTERM_BP_DIRECT
1906	GO:0035690	cellular response to drug	GOTERM_BP_DIRECT
1906	GO:0008217	regulation of blood pressure	GOTERM_BP_DIRECT
1906	GO:0008284	positive regulation of cell proliferation	GOTERM_BP_DIRECT
1906	GO:0014032	neural crest cell development	GOTERM_BP_DIRECT
1906	GO:0030335	positive regulation of cell migration	GOTERM_BP_DIRECT
1906	GO:0031583	phospholipase D-activating G-protein coupled receptor signaling pathway	GOTERM_BP_DIRECT
1906	GO:0006885	regulation of pH	GOTERM_BP_DIRECT
1906	GO:0032308	positive regulation of prostaglandin secretion	GOTERM_BP_DIRECT
1906	GO:0007186	G-protein coupled receptor signaling pathway	GOTERM_BP_DIRECT
1906	GO:0010460	positive regulation of heart rate	GOTERM_BP_DIRECT
1906	GO:0001569	patterning of blood vessels	GOTERM_BP_DIRECT
1906	GO:0007507	heart development	GOTERM_BP_DIRECT
1906	GO:0010870	positive regulation of receptor biosynthetic process	GOTERM_BP_DIRECT
1906	GO:0030195	negative regulation of blood coagulation	GOTERM_BP_DIRECT
1906	GO:0016049	cell growth	GOTERM_BP_DIRECT
1906	GO:0035094	response to nicotine	GOTERM_BP_DIRECT
1906	GO:0001821	histamine secretion	GOTERM_BP_DIRECT
1906	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	GOTERM_BP_DIRECT
1906	GO:0009953	dorsal/ventral pattern formation	GOTERM_BP_DIRECT
1906	GO:0014065	phosphatidylinositol 3-kinase signaling	GOTERM_BP_DIRECT
1906	GO:0030593	neutrophil chemotaxis	GOTERM_BP_DIRECT
1906	GO:0032496	response to lipopolysaccharide	GOTERM_BP_DIRECT
1906	GO:0035556	intracellular signal transduction	GOTERM_BP_DIRECT
1906	GO:0001701	in utero embryonic development	GOTERM_BP_DIRECT
1906	GO:0003100	regulation of systemic arterial blood pressure by endothelin	GOTERM_BP_DIRECT
1906	GO:0034392	negative regulation of smooth muscle cell apoptotic process	GOTERM_BP_DIRECT
1906	GO:0001516	prostaglandin biosynthetic process	GOTERM_BP_DIRECT
1906	GO:0007204	positive regulation of cytosolic calcium ion concentration	GOTERM_BP_DIRECT
1906	GO:0010259	multicellular organism aging	GOTERM_BP_DIRECT
1906	GO:0035815	positive regulation of renal sodium excretion	GOTERM_BP_DIRECT
1906	GO:0042310	vasoconstriction	GOTERM_BP_DIRECT
1906	GO:0045429	positive regulation of nitric oxide biosynthetic process	GOTERM_BP_DIRECT
1906	GO:0048661	positive regulation of smooth muscle cell proliferation	GOTERM_BP_DIRECT
1906	GO:0051930	regulation of sensory perception of pain	GOTERM_BP_DIRECT
1906	GO:0060137	maternal process involved in parturition	GOTERM_BP_DIRECT
1906	GO:0045840	positive regulation of mitotic nuclear division	GOTERM_BP_DIRECT
1906	GO:0046887	positive regulation of hormone secretion	GOTERM_BP_DIRECT
1906	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	GOTERM_BP_DIRECT
1906	GO:0071548	response to dexamethasone	GOTERM_BP_DIRECT
1906	GO:0005576	extracellular region	GOTERM_CC_DIRECT
1906	GO:0005125	Notch binding	GOTERM_MF_DIRECT
1906	GO:0045793	positive regulation of cell size	GOTERM_BP_DIRECT
1906	GO:0048016	inositol phosphate-mediated signaling	GOTERM_BP_DIRECT
1906	GO:0071346	cellular response to interferon-gamma	GOTERM_BP_DIRECT
1906	GO:0071398	cellular response to fatty acid	GOTERM_BP_DIRECT
1906	GO:0042554	superoxide anion generation	GOTERM_BP_DIRECT
1906	GO:0045321	leukocyte activation	GOTERM_BP_DIRECT
1906	GO:0043200	response to amino acid	GOTERM_BP_DIRECT
1906	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
1906	GO:0051899	membrane depolarization	GOTERM_BP_DIRECT
1906	GO:0071356	cellular response to tumor necrosis factor	GOTERM_BP_DIRECT
1906	GO:0042045	epithelial fluid transport	GOTERM_BP_DIRECT
1906	GO:0042313	protein kinase C deactivation	GOTERM_BP_DIRECT
1906	GO:0051216	cartilage development	GOTERM_BP_DIRECT
1906	GO:1902074	response to salt	GOTERM_BP_DIRECT
1906	GO:0005515	protein binding	GOTERM_MF_DIRECT
1906	GO:0035994	response to muscle stretch	GOTERM_BP_DIRECT
1906	GO:0031707	type 1 angiotensin receptor binding	GOTERM_MF_DIRECT
1906	GO:0042482	positive regulation of odontogenesis	GOTERM_BP_DIRECT
1906	GO:0044321	response to leptin	GOTERM_BP_DIRECT
1906	GO:0031708	type 1 angiotensin receptor binding	GOTERM_MF_DIRECT
1906	GO:0043507	positive regulation of JUN kinase activity	GOTERM_BP_DIRECT
1906	GO:0045987	positive regulation of smooth muscle contraction	GOTERM_BP_DIRECT
1906	GO:0071375	cellular response to peptide hormone stimulus	GOTERM_BP_DIRECT
1906	GO:0071456	cellular response to hypoxia	GOTERM_BP_DIRECT
1906	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	GOTERM_BP_DIRECT
1906	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	GOTERM_BP_DIRECT
1906	GO:0070101	positive regulation of chemokine-mediated signaling pathway	GOTERM_BP_DIRECT
1906	GO:0071389	cellular response to mineralocorticoid stimulus	GOTERM_BP_DIRECT
1906	GO:0005179	integrin binding	GOTERM_MF_DIRECT
1906	GO:0043179	rhythmic excitation	GOTERM_BP_DIRECT
1906	GO:0042474	middle ear morphogenesis	GOTERM_BP_DIRECT
1906	GO:0043406	positive regulation of MAP kinase activity	GOTERM_BP_DIRECT
1906	GO:0005615	extracellular space	GOTERM_CC_DIRECT
1906	GO:0045178	basal part of cell	GOTERM_CC_DIRECT
1906	GO:0046888	negative regulation of hormone secretion	GOTERM_BP_DIRECT
1906	GO:0060298	positive regulation of sarcomere organization	GOTERM_BP_DIRECT
1906	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	GOTERM_BP_DIRECT
1906	GO:0071347	cellular response to interleukin-1	GOTERM_BP_DIRECT
1906	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
1906	GO:0033093	Weibel-Palade body	GOTERM_CC_DIRECT
1906	GO:0048237	rough endoplasmic reticulum lumen	GOTERM_CC_DIRECT
1906	GO:0071277	cellular response to calcium ion	GOTERM_BP_DIRECT
1906	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	GOTERM_BP_DIRECT
1906	GO:0071385	cellular response to glucocorticoid stimulus	GOTERM_BP_DIRECT
1906	GO:0071560	cellular response to transforming growth factor beta stimulus	GOTERM_BP_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
1906	hsa04066	HIF-1 signaling pathway
1906	hsa04668	TNF signaling pathway
1906	hsa04916	Melanogenesis

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
EDN1	1906	Premature Birth	C0151526	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Thrombotic Infarction, Middle Cerebral Artery	C0751848	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Acute Kidney Insufficiency	C1565662	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Cardiac Arrhythmia	C0003811	Finding	0.3	0.417	0.828	phenotype
EDN1	1906	Asthma	C0004096	Disease or Syndrome	0.38	0.417	0.828	disease
EDN1	1906	Atrial Fibrillation	C0004238	Disease or Syndrome	0.31	0.417	0.828	disease
EDN1	1906	Hypercholesterolemia	C0020443	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Hypotension	C0020649	Finding	0.31	0.417	0.828	phenotype
EDN1	1906	Chondromalacia	C0085700	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Craniofacial Abnormalities	C0376634	Congenital Abnormality	0.3	0.417	0.828	group
EDN1	1906	Hyperalgesia, Thermal	C0751214	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Diabetes Mellitus, Experimental	C0011853	Experimental Model of Disease	0.3	0.417	0.828	disease
EDN1	1906	Acute Lung Injury	C0242488	Injury or Poisoning	0.3	0.417	0.828	disease
EDN1	1906	Subarachnoid Hemorrhage, Spontaneous	C0472383	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Functional Gastrointestinal Disorders	C0559031	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Pain, Migratory	C0751407	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Acute Cerebrovascular Accidents	C0751956	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Cerebrovascular Disorders	C0007820	Disease or Syndrome	0.3	0.417	0.828	group
EDN1	1906	Hyperalgesia	C0020429	Sign or Symptom	0.31	0.417	0.828	phenotype
EDN1	1906	Pulmonary Hypertension	C0020542	Pathologic Function	0.53	0.417	0.828	phenotype
EDN1	1906	Cardiomyopathies, Primary	C0033141	Disease or Syndrome	0.3	0.417	0.828	group
EDN1	1906	Ureteral obstruction	C0041956	Anatomical Abnormality	0.3	0.417	0.828	phenotype
EDN1	1906	Urinary Retention	C0080274	Finding	0.3	0.417	0.828	phenotype
EDN1	1906	Overactive Detrusor	C0268849	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Right Middle Cerebral Artery Infarction	C0751849	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Cardiomegaly	C0018800	Finding	0.31	0.417	0.828	phenotype
EDN1	1906	Myocardial Reperfusion Injury	C0027055	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Heart Decompensation	C1961112	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Cardiovascular Diseases	C0007222	Disease or Syndrome	0.37	0.417	0.828	group
EDN1	1906	Neoplastic Cell Transformation	C0007621	Neoplastic Process	0.3	0.417	0.828	phenotype
EDN1	1906	Pain	C0030193	Sign or Symptom	0.35	0.417	0.828	phenotype
EDN1	1906	Heart Failure, Right-Sided	C0235527	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Pain, Splitting	C0458257	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Hyperalgesia, Primary	C0751211	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Persistent atrial fibrillation	C2585653	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Respiratory Distress Syndrome, Adult	C0035222	Disease or Syndrome	0.5	0.417	0.828	disease
EDN1	1906	Subarachnoid Hemorrhage	C0038525	Disease or Syndrome	0.35	0.417	0.828	disease
EDN1	1906	Paroxysmal atrial fibrillation	C0235480	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Perinatal Subarachnoid Hemorrhage	C0270192	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Acute kidney injury	C2609414	Injury or Poisoning	0.3	0.417	0.828	disease
EDN1	1906	Cartilage Diseases	C0007302	Disease or Syndrome	0.3	0.417	0.828	group
EDN1	1906	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.417	0.828	disease
EDN1	1906	Pre-Eclampsia	C0032914	Pathologic Function	0.32	0.417	0.828	phenotype
EDN1	1906	Cerebrovascular Insufficiency	C0241832	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Allodynia	C0458247	Finding	0.3	0.417	0.828	phenotype
EDN1	1906	Tactile Allodynia	C0751213	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Lewy Body Disease	C0752347	Disease or Syndrome	0.31	0.417	0.828	disease
EDN1	1906	Kidney Failure, Acute	C0022660	Disease or Syndrome	0.32	0.417	0.828	disease
EDN1	1906	Marginal ulcer	C0024799	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Kidney Failure	C0035078	Disease or Syndrome	0.51	0.417	0.828	disease
EDN1	1906	Left Ventricular Hypertrophy	C0149721	Disease or Syndrome	0.34	0.417	0.828	disease
EDN1	1906	Middle Cerebral Artery Syndrome	C0238281	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Cerebrovascular Occlusion	C0596298	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Middle Cerebral Artery Thrombosis	C0740376	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Embolic Infarction, Middle Cerebral Artery	C0751847	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Focal glomerulosclerosis	C0017668	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Hypertensive disease	C0020538	Disease or Syndrome	0.6	0.417	0.828	group
EDN1	1906	Oral Ulcer	C0149745	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Pain, Burning	C0234230	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Cardiovascular Abnormalities	C0243050	Congenital Abnormality	0.3	0.417	0.828	group
EDN1	1906	Suffering, Physical	C0751408	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Gastrointestinal Diseases	C0017178	Disease or Syndrome	0.3	0.417	0.828	group
EDN1	1906	Diaphragmatic Hernia	C0019284	Anatomical Abnormality	0.3	0.417	0.828	phenotype
EDN1	1906	Hamman-Rich syndrome	C0085786	Disease or Syndrome	0.32	0.417	0.828	disease
EDN1	1906	Pain, Crushing	C0458259	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Subarachnoid Hemorrhage, Aneurysmal	C0751530	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Middle Cerebral Artery Embolus	C0751845	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Left Middle Cerebral Artery Infarction	C0751846	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	familial atrial fibrillation	C3468561	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Diabetes Mellitus, Non-Insulin-Dependent	C0011860	Disease or Syndrome	0.59	0.417	0.828	disease
EDN1	1906	Hepatorenal Syndrome	C0019212	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Parkinson Disease	C0030567	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Streptozotocin Diabetes	C0038433	Experimental Model of Disease	0.3	0.417	0.828	disease
EDN1	1906	Cerebrovascular accident	C0038454	Disease or Syndrome	0.33	0.417	0.828	group
EDN1	1906	Ache	C0234238	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Erectile dysfunction	C0242350	Finding	0.51	0.417	0.828	disease
EDN1	1906	Myocardial Failure	C1959583	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Mechanical Allodynia	C2936719	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Heart failure	C0018801	Disease or Syndrome	0.6	0.417	0.828	disease
EDN1	1906	Peptic Ulcer	C0030920	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Reperfusion Injury	C0035126	Injury or Poisoning	0.3	0.417	0.828	disease
EDN1	1906	Myocardial Diseases, Secondary	C0036529	Disease or Syndrome	0.3	0.417	0.828	group
EDN1	1906	Hyalinosis, Segmental Glomerular	C0086432	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Bradycardia	C0428977	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Subarachnoid Hemorrhage, Intracranial	C0795688	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Cardiac Hypertrophy	C1383860	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Renal Insufficiency	C1565489	Disease or Syndrome	0.31	0.417	0.828	disease
EDN1	1906	Congenital Heart Defects	C0018798	Congenital Abnormality	0.3	0.417	0.828	group
EDN1	1906	Hypertrophy	C0020564	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Inflammation	C0021368	Pathologic Function	0.3	0.417	0.828	phenotype
EDN1	1906	Nephrosis	C0027720	Disease or Syndrome	0.5	0.417	0.828	disease
EDN1	1906	Pulmonary Fibrosis	C0034069	Disease or Syndrome	0.58	0.417	0.828	disease
EDN1	1906	Middle Cerebral Artery Occlusion	C0740391	Acquired Abnormality	0.31	0.417	0.828	phenotype
EDN1	1906	Cardiomyopathies	C0878544	Disease or Syndrome	0.31	0.417	0.828	group
EDN1	1906	Alloxan Diabetes	C0002152	Experimental Model of Disease	0.3	0.417	0.828	disease
EDN1	1906	Congestive heart failure	C0018802	Disease or Syndrome	0.6	0.417	0.828	disease
EDN1	1906	Kidney Diseases	C0022658	Disease or Syndrome	0.37	0.417	0.828	group
EDN1	1906	Left-Sided Heart Failure	C0023212	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Myocardial Ischemia	C0151744	Disease or Syndrome	0.52	0.417	0.828	disease
EDN1	1906	Radiating pain	C0234254	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Infarction, Middle Cerebral Artery	C0740392	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Hyperalgesia, Secondary	C0751212	Sign or Symptom	0.3	0.417	0.828	phenotype
EDN1	1906	Overactive Bladder	C0878773	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Cholera Infantum	C1565321	Disease or Syndrome	0.3	0.417	0.828	disease
EDN1	1906	Auriculo-condylar syndrome	C1865295	Disease or Syndrome	0.51	0.417	0.828	disease
EDN1	1906	Mood Disorders	C0525045	Mental or Behavioral Dysfunction	0.01	0.417	0.828	group
EDN1	1906	QUESTION MARK EARS, ISOLATED	C2748545	Anatomical Abnormality	0.41	0.417	0.828	phenotype
EDN1	1906	AURICULOCONDYLAR SYNDROME 3	C3810332	Disease or Syndrome	0.4	0.417	0.828	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
EDN1	1906	ANESTHETIC AGENT	None	None	None
EDN1	1906	ANTICONVULSANT	None	None	None
EDN1	1906	ANTIPLATELET AGENT	None	None	None
EDN1	1906	BUDESONIDE	BUDESONIDE	CHEMBL1370	None
EDN1	1906	CANDESARTAN CILEXETIL	CANDESARTAN CILEXETIL	CHEMBL1014	None
EDN1	1906	CELECOXIB	CELECOXIB	CHEMBL118	None
EDN1	1906	DEFEROXAMINE	DEFEROXAMINE	CHEMBL556	None
EDN1	1906	DOXORUBICIN	DOXORUBICIN	CHEMBL53463	None
EDN1	1906	IL-33	ETIOCHOLANOLONE	CHEMBL85799	agonist
EDN1	1906	INSULIN	None	None	None
EDN1	1906	LANREOTIDE	LANREOTIDE	CHEMBL1201185	None
EDN1	1906	NORETHISTERONE ACETATE	None	None	None
EDN1	1906	OXYGEN THERAPY	None	None	None
EDN1	1906	PROTEIN SYNTHESIS INHIBITOR	None	None	None
EDN1	1906	PROSTAGLANDIN E1	ALPROSTADIL	CHEMBL495	None
EDN1	1906	TAMOXIFEN	TAMOXIFEN	CHEMBL83	None
EDN1	1906	THIOURACIL	THIOURACIL	CHEMBL345768	None