Cell division control protein 42 homolog

AltitudeomicsDB
Protein Official symbol CDC42
Aliases CDC42
Chromosomal Location  1
Length 191
Uniprot ID P60953
EC number 3.6.5.2
Protein family Information(Pfam) PF00071;
PDB id 1A4R;1AJE;1AM4;1AN0;1CEE;1CF4;1DOA;1E0A;1EES;1GRN;1GZS;1KI1;1KZ7;1KZG;1NF3;2ASE;2DFK;2KB0;2NGR;2ODB;2QRZ;2WM9;2WMN;2WMO;3GCG;3QBV;3VHL;4DID;4ITR;4JS0;4YC7;4YDH;5CJP;5FI1;5HZK;5UPK;5UPL;6AJ4;6AJL;6SIU;6SUP;6TKY;6TKZ;
InterPro ID IPR037874;IPR027417;IPR005225;IPR001806;IPR003578;
dbSNP rs864309721

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CDC42 WAS 0.997
CDC42 WASL 0.995
CDC42 PARD6A 0.993
CDC42 ACTR2 0.991
CDC42 PAK1 0.991
CLIP1 CDC42 0.99
CDC42 IQGAP1 0.99
CDC42 ARHGAP1 0.989
CDC42 ARHGDIA 0.989
ACTR2 WAS 0.989
CDC42 SRC 0.986
ACTR2 WASL 0.986
CLIP1 IQGAP1 0.984
SRC WASL 0.979
PAK1 ARHGDIA 0.968
SRC IQGAP1 0.964
SRC PAK1 0.932
SRC PARD6A 0.927
WAS WASL 0.906
IQGAP1 WASL 0.813
WAS SRC 0.811
SRC ARHGDIA 0.663
ACTR2 SRC 0.658
ARHGAP1 ARHGDIA 0.579
ACTR2 IQGAP1 0.555
WAS IQGAP1 0.521
WAS PAK1 0.521
ACTR2 ARHGDIA 0.472
SRC ARHGAP1 0.471
PAK1 WASL 0.445
CLIP1 WASL 0.412
ARHGDIA WASL 0.408
ACTR2 PAK1 0.404
Gene Ontology Semantic Similarity
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# 998 (CDC42) 6249 (CLIP1) 10097 (ACTR2) 6714 (SRC) 5058 (PAK1) 7454 (WAS) 8826 (IQGAP1) 392 (ARHGAP1) 396 (ARHGDIA) 8976 (WASL) 50855 (PARD6A) 2167 (FABP4)
998 (CDC42) 1.00 0.54 0.29 0.71 0.66 0.62 0.57 0.52 0.50 0.51 0.61 0.20
6249 (CLIP1) 0.54 1.00 0.44 0.58 0.55 0.63 0.62 0.57 0.56 0.62 0.64 0.24
10097 (ACTR2) 0.29 0.44 1.00 0.33 0.36 0.45 0.33 0.33 0.33 0.59 0.38 0.17
6714 (SRC) 0.71 0.58 0.33 1.00 0.76 0.62 0.61 0.64 0.57 0.57 0.62 0.20
5058 (PAK1) 0.66 0.55 0.36 0.76 1.00 0.66 0.55 0.56 0.63 0.52 0.68 0.19
7454 (WAS) 0.62 0.63 0.45 0.62 0.66 1.00 0.75 0.74 0.79 0.82 0.77 0.21
8826 (IQGAP1) 0.57 0.62 0.33 0.61 0.55 0.75 1.00 0.74 0.65 0.67 0.65 0.23
392 (ARHGAP1) 0.52 0.57 0.33 0.64 0.56 0.74 0.74 1.00 0.72 0.73 0.71 0.21
396 (ARHGDIA) 0.50 0.56 0.33 0.57 0.63 0.79 0.65 0.72 1.00 0.75 0.76 0.21
8976 (WASL) 0.51 0.62 0.59 0.57 0.52 0.82 0.67 0.73 0.75 1.00 0.67 0.22
50855 (PARD6A) 0.61 0.64 0.38 0.62 0.68 0.77 0.65 0.71 0.76 0.67 1.00 0.23
2167 (FABP4) 0.20 0.24 0.17 0.20 0.19 0.21 0.23 0.21 0.21 0.22 0.23 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CDC42 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 CDC42 998 distal 22955619 TRANSFAC
EGR1 1958 CDC42 998 proximal_filtered 22955619 TRANSFAC
NRF1 4899 CDC42 998 proximal_filtered 22955619 TRANSFAC
PTTG1 9232 CDC42 998 Repression 20363964 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT000327 hsa-miR-133a-3p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25152372
MIRT000636 hsa-miR-224-5p Homo sapiens CDC42 998 Homo sapiens Microarray//qRT-PCR//Western blot Functional MTI 22989374
MIRT000636 hsa-miR-224-5p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 20023705
MIRT000636 hsa-miR-224-5p Homo sapiens CDC42 998 Homo sapiens qRT-PCR Functional MTI (Weak) 24817781
MIRT004037 hsa-miR-185-5p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 21186079
MIRT005485 hsa-miR-137 Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//Western blot//Reporter assay;Other Functional MTI 20473940
MIRT005485 hsa-miR-137 Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay Functional MTI 23178712
MIRT005485 hsa-miR-137 Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 21221794
MIRT005485 hsa-miR-137 Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24465609
MIRT005965 hsa-miR-330-3p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 23337504
MIRT005965 hsa-miR-330-3p Homo sapiens CDC42 998 Homo sapiens Immunohistochemistry//Luciferase reporter assay//Western blot Functional MTI 21149267
MIRT005964 hsa-miR-216a-5p Homo sapiens CDC42 998 Homo sapiens Immunohistochemistry//Luciferase reporter assay//Western blot Functional MTI 21149267
MIRT005966 hsa-miR-608 Homo sapiens CDC42 998 Homo sapiens Immunohistochemistry//Luciferase reporter assay//Western blot Functional MTI 21149267
MIRT006490 hsa-miR-29a-3p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 19079265
MIRT006488 hsa-miR-29b-3p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 19079265
MIRT006489 hsa-miR-29c-3p Homo sapiens CDC42 998 Homo sapiens qRT-PCR//Western blot Functional MTI 20507733
MIRT006490 hsa-miR-29a-3p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay Functional MTI 24085298
MIRT006490 hsa-miR-29a-3p Homo sapiens CDC42 998 Homo sapiens qRT-PCR//Western blot Functional MTI 20507733
MIRT006995 hsa-miR-195-5p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24025765
MIRT006489 hsa-miR-29c-3p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 19079265
MIRT006488 hsa-miR-29b-3p Homo sapiens CDC42 998 Homo sapiens qRT-PCR//Western blot Functional MTI 20507733
MIRT006995 hsa-miR-195-5p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay Functional MTI 22802111
MIRT019885 hsa-miR-375 Homo sapiens CDC42 998 Homo sapiens qRT-PCR;Microarray Functional MTI (Weak) 20584986
MIRT023726 hsa-miR-1-3p Homo sapiens CDC42 998 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT038837 hsa-miR-93-3p Homo sapiens CDC42 998 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT041813 hsa-miR-484 Homo sapiens CDC42 998 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044369 hsa-miR-106b-5p Homo sapiens CDC42 998 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT053177 hsa-miR-133b Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25152372
MIRT053177 hsa-miR-133b Homo sapiens CDC42 998 Homo sapiens Immunoblot//Luciferase reporter assay//Microarray Functional MTI 22179829
MIRT054636 hsa-miR-204-5p Homo sapiens CDC42 998 Homo sapiens ChIP-seq//Immunofluorescence//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24613926
MIRT133821 hsa-miR-20a-3p Homo sapiens CDC42 998 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT704845 hsa-miR-21-3p Homo sapiens CDC42 998 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT704842 hsa-miR-1207-3p Homo sapiens CDC42 998 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT704843 hsa-miR-3914 Homo sapiens CDC42 998 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT704844 hsa-miR-3591-3p Homo sapiens CDC42 998 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT734260 hsa-miR-107 Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 28393193
MIRT734762 hsa-miR-30c-5p Homo sapiens CDC42 998 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25781190
Gene Ontology
ID GO ID GO Term GO Type
998 GO:0030225 macrophage differentiation GOTERM_BP_DIRECT
998 GO:0045859 regulation of protein kinase activity GOTERM_BP_DIRECT
998 GO:0048664 neuron fate determination GOTERM_BP_DIRECT
998 GO:0060684 epithelial-mesenchymal cell signaling GOTERM_BP_DIRECT
998 GO:0090135 actin filament branching GOTERM_BP_DIRECT
998 GO:0007596 blood coagulation GOTERM_BP_DIRECT
998 GO:0010628 positive regulation of gene expression GOTERM_BP_DIRECT
998 GO:0072384 organelle transport along microtubule GOTERM_BP_DIRECT
998 GO:0090136 epithelial cell-cell adhesion GOTERM_BP_DIRECT
998 GO:0090316 positive regulation of intracellular protein transport GOTERM_BP_DIRECT
998 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
998 GO:0002040 sprouting angiogenesis GOTERM_BP_DIRECT
998 GO:0032467 positive regulation of cytokinesis GOTERM_BP_DIRECT
998 GO:0060047 heart contraction GOTERM_BP_DIRECT
998 GO:0060789 hair follicle placode formation GOTERM_BP_DIRECT
998 GO:0051022 GTPase binding GOTERM_MF_DIRECT
998 GO:0005911 cell-cell junction GOTERM_CC_DIRECT
998 GO:0003161 cardiac conduction system development GOTERM_BP_DIRECT
998 GO:0007097 nuclear migration GOTERM_BP_DIRECT
998 GO:0036336 dendritic cell migration GOTERM_BP_DIRECT
998 GO:0016020 membrane GOTERM_CC_DIRECT
998 GO:0034191 apolipoprotein receptor binding GOTERM_MF_DIRECT
998 GO:0005622 intracellular GOTERM_CC_DIRECT
998 GO:0030141 secretory granule GOTERM_CC_DIRECT
998 GO:0030175 filopodium GOTERM_CC_DIRECT
998 GO:0007264 small GTPase mediated signal transduction GOTERM_BP_DIRECT
998 GO:0033138 positive regulation of peptidyl-serine phosphorylation GOTERM_BP_DIRECT
998 GO:0048013 ephrin receptor signaling pathway GOTERM_BP_DIRECT
998 GO:0005515 protein binding GOTERM_MF_DIRECT
998 GO:0030742 protein binding GOTERM_MF_DIRECT
998 GO:0042802 identical protein binding GOTERM_MF_DIRECT
998 GO:0034613 cellular protein localization GOTERM_BP_DIRECT
998 GO:0035088 establishment or maintenance of apical/basal cell polarity GOTERM_BP_DIRECT
998 GO:0043497 regulation of protein heterodimerization activity GOTERM_BP_DIRECT
998 GO:0051149 positive regulation of muscle cell differentiation GOTERM_BP_DIRECT
998 GO:0003924 GTPase activity GOTERM_MF_DIRECT
998 GO:0005925 focal adhesion GOTERM_CC_DIRECT
998 GO:0030496 midbody GOTERM_CC_DIRECT
998 GO:0034332 adherens junction organization GOTERM_BP_DIRECT
998 GO:0039694 viral RNA genome replication GOTERM_BP_DIRECT
998 GO:0043525 positive regulation of neuron apoptotic process GOTERM_BP_DIRECT
998 GO:0071338 positive regulation of hair follicle cell proliferation GOTERM_BP_DIRECT
998 GO:0061630 endopeptidase activator activity GOTERM_MF_DIRECT
998 GO:0007163 establishment or maintenance of cell polarity GOTERM_BP_DIRECT
998 GO:0031424 keratinization GOTERM_BP_DIRECT
998 GO:0046330 positive regulation of JNK cascade GOTERM_BP_DIRECT
998 GO:0051683 establishment of Golgi localization GOTERM_BP_DIRECT
998 GO:0051835 positive regulation of synapse structural plasticity GOTERM_BP_DIRECT
998 GO:0051988 regulation of attachment of spindle microtubules to kinetochore GOTERM_BP_DIRECT
998 GO:0060071 Wnt signaling pathway GOTERM_BP_DIRECT
998 GO:0000139 Golgi membrane GOTERM_CC_DIRECT
998 GO:0005815 microtubule organizing center GOTERM_CC_DIRECT
998 GO:0007088 regulation of mitotic nuclear division GOTERM_BP_DIRECT
998 GO:0031274 positive regulation of pseudopodium assembly GOTERM_BP_DIRECT
998 GO:0060661 submandibular salivary gland formation GOTERM_BP_DIRECT
998 GO:0030307 positive regulation of cell growth GOTERM_BP_DIRECT
998 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GOTERM_BP_DIRECT
998 GO:0046847 filopodium assembly GOTERM_BP_DIRECT
998 GO:0005525 GTP binding GOTERM_MF_DIRECT
998 GO:0031069 hair follicle morphogenesis GOTERM_BP_DIRECT
998 GO:0031647 regulation of protein stability GOTERM_BP_DIRECT
998 GO:0035264 multicellular organism growth GOTERM_BP_DIRECT
998 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity GOTERM_BP_DIRECT
998 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading GOTERM_BP_DIRECT
998 GO:0019901 protein kinase binding GOTERM_MF_DIRECT
998 GO:0031435 L-ascorbic acid binding GOTERM_MF_DIRECT
998 GO:0031996 insulin-like growth factor II binding GOTERM_MF_DIRECT
998 GO:0003334 keratinocyte development GOTERM_BP_DIRECT
998 GO:0007030 Golgi organization GOTERM_BP_DIRECT
998 GO:0016567 protein ubiquitination GOTERM_BP_DIRECT
998 GO:0060070 canonical Wnt signaling pathway GOTERM_BP_DIRECT
998 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis GOTERM_BP_DIRECT
998 GO:0006897 endocytosis GOTERM_BP_DIRECT
998 GO:0021762 substantia nigra development GOTERM_BP_DIRECT
998 GO:0031295 T cell costimulation GOTERM_BP_DIRECT
998 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GOTERM_BP_DIRECT
998 GO:0045740 positive regulation of DNA replication GOTERM_BP_DIRECT
998 GO:0051017 actin filament bundle assembly GOTERM_BP_DIRECT
998 GO:0051056 regulation of small GTPase mediated signal transduction GOTERM_BP_DIRECT
998 GO:0005829 cytosol GOTERM_CC_DIRECT
998 GO:0030036 actin cytoskeleton organization GOTERM_BP_DIRECT
998 GO:0031333 negative regulation of protein complex assembly GOTERM_BP_DIRECT
998 GO:0048010 vascular endothelial growth factor receptor signaling pathway GOTERM_BP_DIRECT
998 GO:0051301 cell division GOTERM_BP_DIRECT
998 GO:0051489 regulation of filopodium assembly GOTERM_BP_DIRECT
998 GO:0000322 storage vacuole GOTERM_CC_DIRECT
998 GO:0005886 plasma membrane GOTERM_CC_DIRECT
998 GO:0010629 negative regulation of gene expression GOTERM_BP_DIRECT
998 GO:0042176 regulation of protein catabolic process GOTERM_BP_DIRECT
998 GO:0005737 cytoplasm GOTERM_CC_DIRECT
998 GO:0031256 leading edge membrane GOTERM_CC_DIRECT
998 GO:0045177 apical part of cell GOTERM_CC_DIRECT
998 GO:0043005 neuron projection GOTERM_CC_DIRECT
998 GO:0036464 cytoplasmic ribonucleoprotein granule GOTERM_CC_DIRECT
998 GO:0043209 myelin sheath GOTERM_CC_DIRECT
998 GO:0043025 neuronal cell body GOTERM_CC_DIRECT
998 GO:0042995 cell projection GOTERM_CC_DIRECT
998 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
998 GO:0051233 spindle midzone GOTERM_CC_DIRECT
998 GO:0072686 mitotic spindle GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
998 hsa04010 MAPK signaling pathway
998 hsa04014 Ras signaling pathway
998 hsa04062 Chemokine signaling pathway
998 hsa04015 Rap1 signaling pathway
998 hsa04144 Endocytosis
998 hsa04510 Focal adhesion
998 hsa04370 VEGF signaling pathway
998 hsa04660 T cell receptor signaling pathway
998 hsa04360 Axon guidance
998 hsa04530 Tight junction
998 hsa04666 Fc gamma R-mediated phagocytosis
998 hsa04520 Adherens junction
998 hsa04670 Leukocyte transendothelial migration
998 hsa04722 Neurotrophin signaling pathway
998 hsa04810 Regulation of actin cytoskeleton
998 hsa04912 GnRH signaling pathway
998 hsa04932 Non-alcoholic fatty liver disease
998 hsa05130 Pathogenic Escherichia coli infection
998 hsa05100 Bacterial invasion of epithelial cells
998 hsa05131 Shigellosis
998 hsa05120 Epithelial cell signaling in Helicobacter pylori infection
998 hsa05132 Salmonella infection
998 hsa05200 Pathways in cancer
998 hsa05203 Viral carcinogenesis
998 hsa05212 Pancreatic cancer
998 hsa05211 Renal cell carcinoma
998 hsa05205 Proteoglycans in cancer
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CDC42 998 Carcinoma C0007097 Neoplastic Process 0.3 0.511 0.828 group
CDC42 998 Carcinoma, Spindle-Cell C0205697 Neoplastic Process 0.3 0.511 0.828 disease
CDC42 998 Undifferentiated carcinoma C0205698 Neoplastic Process 0.3 0.511 0.828 phenotype
CDC42 998 HIV Coinfection C4505456 Disease or Syndrome 0.3 0.511 0.828 disease
CDC42 998 Animal Mammary Neoplasms C0024667 Neoplastic Process 0.3 0.511 0.828 group
CDC42 998 Necrosis C0027540 Organ or Tissue Function 0.3 0.511 0.828 phenotype
CDC42 998 Adrenal Gland Neoplasms C0001624 Neoplastic Process 0.3 0.511 0.828 group
CDC42 998 Anaplastic carcinoma C0205696 Neoplastic Process 0.3 0.511 0.828 disease
CDC42 998 Carcinomatosis C0205699 Neoplastic Process 0.3 0.511 0.828 phenotype
CDC42 998 Adrenal Cancer C0750887 Neoplastic Process 0.3 0.511 0.828 disease
CDC42 998 Mammary Carcinoma, Animal C1257925 Neoplastic Process 0.3 0.511 0.828 disease
CDC42 998 HIV Infections C0019693 Disease or Syndrome 0.32 0.511 0.828 group
CDC42 998 Mammary Neoplasms, Experimental C0024668 Experimental Model of Disease; Neoplastic Process 0.3 0.511 0.828 group
CDC42 998 TAKENOUCHI-KOSAKI SYNDROME C4225222 Disease or Syndrome 0.7 0.511 0.828 disease
CDC42 998 Lymphatic Diseases C0024228 Disease or Syndrome 0.3 0.511 0.828 group
CDC42 998 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.32 0.511 0.828 group
CDC42 998 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.34 0.511 0.828 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
CDC42 998 GNRH GONADORELIN ACETATE CHEMBL1200511 None