ALTITUDEOMICSDB

Ras GTPase-activating-like protein IQGAP1

AltitudeomicsDB

Protein Official symbol	IQGAP1
Aliases	IQGAP1 KIAA0051
Chromosomal Location	15
Length	1657
Uniprot ID	P46940
EC number	None
Protein family Information(Pfam)	PF00307;PF00612;PF00616;PF03836;
PDB id	1X0H;2RR8;3FAY;3I6X;5L0O;
InterPro ID	IPR001715;IPR036872;IPR000048;IPR027417;IPR000593;IPR023152;IPR001936;IPR008936;IPR001202;
dbSNP	rs12324924

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
VEGFA	KDR	0.998
CTNNB1	CDH1	0.995
CDH5	KDR	0.994
CTNND1	CDH1	0.991
CLIP1	CDC42	0.99
CDC42	IQGAP1	0.99
HRAS	RAF1	0.989
VEGFA	FN1	0.988
VEGFA	CDH5	0.988
VEGFA	SRC	0.987
SRC	VCL	0.987
HRAS	MAP2K1	0.986
CDC42	SRC	0.986
TLN1	VCL	0.986
BRAF	KRAS	0.986
HRAS	BRAF	0.986
SRC	CDH1	0.985
CDC42	EXOC7	0.984
CLIP1	IQGAP1	0.984
KSR1	CNKSR1	0.984
CTNND1	CDH5	0.984
CTNND1	SRC	0.983
FN1	VCL	0.983
CTNNB1	CTNNA1	0.983
HRAS	SRC	0.983
RHOA	CDH1	0.981
HRAS	MAPK3	0.981
RHOA	CTNND1	0.981
RHOA	VCL	0.981
HRAS	MAP2K2	0.98
VEGFA	CTNNB1	0.979
NRAS	MAP2K1	0.979
HRAS	MAPK1	0.979
CDH1	VCL	0.979
RHOA	MAPK1	0.979
SRC	CTNNB1	0.979
CTNND1	CTNNA1	0.979
RHOA	IQGAP1	0.979
CLIP1	PAFAH1B1	0.979
MAPK3	KRAS	0.979
MAP2K1	KRAS	0.979
CTNNB1	CDH5	0.978
CDC42	CDH1	0.978
NRAS	BRAF	0.978
NRAS	RAF1	0.978
RHOA	SRC	0.977
CTNND1	CTNNB1	0.977
VEGFA	RHOA	0.977
RHOA	DIAPH1	0.976
KSR1	MAP2K1	0.976
IQGAP1	CDH1	0.975
KRAS	RAF1	0.975
SRC	FN1	0.975
HRAS	ARAF	0.974
KRAS	MAPK1	0.973
CDH1	MAPK1	0.973
NRAS	MAPK3	0.973
RHOA	MAPK3	0.972
SRC	KRAS	0.971
VEGFA	CDC42	0.971
FN1	MAPK3	0.97
NRAS	MAP2K2	0.97
NRAS	MAPK1	0.97
MAP2K2	KRAS	0.97
CTNNB1	IQGAP1	0.969
KSR1	MAP2K2	0.969
ILK	IQGAP1	0.968
ARRB1	MAPK1	0.968
NRAS	ARAF	0.968
CDC42	FN1	0.968
CTNND1	VCL	0.968
KSR1	MAPK1	0.967
KSR1	MAPK3	0.967
RAPGEF3	RAP1A	0.967
MAPK3	CDH1	0.966
FN1	MAPK1	0.965
EXOC7	IQGAP1	0.965
ARRB1	MAPK3	0.965
IQGAP1	MAPK1	0.965
CDC42	CTNND1	0.964
RAPGEF3	RAP1B	0.964
IQGAP1	MAPK3	0.964
SRC	IQGAP1	0.964
ARAF	KRAS	0.963
NPHS1	IQGAP1	0.963
CTNNB1	VCL	0.962
CTNNB1	MEN1	0.962
RHOA	CDH5	0.961
HRAS	IQGAP1	0.96
SRC	RAC1	0.959
RHOA	CTNNB1	0.959
HRAS	FN1	0.958
RAC1	IQGAP1	0.958
MAPK3	VCL	0.958
CDH5	IQGAP1	0.957
CNKSR1	RAF1	0.957
2002-09-01T00:00:00	EXOC7	0.957
IQGAP1	KDR	0.956
IQGAP1	MAP2K2	0.956
ARRB1	SRC	0.955
CDC42	CTNNB1	0.955
RAC1	CDH5	0.955
RAP1A	IQGAP1	0.954
CTNNA1	CDH1	0.953
FN1	KRAS	0.953
RAPGEF3	AKAP5	0.953
RAP1A	TLN1	0.952
LMNA	VCL	0.952
ILK	CTNNB1	0.951
2002-09-01T00:00:00	IQGAP1	0.951
HRAS	KSR1	0.951
RHOA	KDR	0.95
FN1	MAP2K1	0.95
RAC1	EXOC7	0.95
FN1	TLN1	0.95
CTNNB1	KDR	0.949
RAP1A	RAF1	0.949
MAPK1	VCL	0.949
RHOA	TLN1	0.948
MAPK3	MAP2K2	0.948
MAP2K1	MAPK3	0.948
IQGAP1	VCL	0.948
SRC	NRAS	0.947
CDC42	KDR	0.947
MAP2K1	MAPK1	0.947
LMNA	MAPK3	0.947
RAC1	MAP2K1	0.947
SRC	TLN1	0.947
MAP2K2	MAPK1	0.946
2002-09-01T00:00:00	CDC42	0.946
RAC1	FN1	0.946
CTNND1	RAC1	0.946
CDC42	PAFAH1B1	0.946
TLN1	RAP1B	0.945
KSR1	IQGAP1	0.945
RAC1	MAPK3	0.945
CTNND1	IQGAP1	0.943
CSK	VCL	0.943
NPHS1	KIRREL	0.943
LMNA	FN1	0.943
RHOA	CSK	0.943
KSR1	NRAS	0.942
YWHAB	RAF1	0.942
MAP2K1	RAF1	0.942
RAC1	CDH1	0.942
MAP2K1	IQGAP1	0.942
LMNA	MAPK1	0.942
CTNNA1	IQGAP1	0.942
SRC	MAPK3	0.941
KSR1	KRAS	0.94
TLN1	IQGAP1	0.94
HRAS	VCL	0.94
SRC	MAPK1	0.94
RAC1	MAPK1	0.94
HRAS	LMNA	0.939
RAP1A	VCL	0.939
ARAF	MAP2K2	0.939
FN1	CSK	0.939
MAP2K1	BRAF	0.939
MAP2K1	ARAF	0.939
RAF1	MAPK1	0.938
IQGAP1	RAP1B	0.938
MAP2K2	RAF1	0.937
RAC1	MAP2K2	0.937
RAF1	RAP1B	0.937
VEGFA	CSK	0.937
SRC	MAP2K1	0.936
ARRB1	MAP2K1	0.936
MAPK3	RAF1	0.936
SRC	RAP1A	0.935
RAP1A	MAPK3	0.935
KRAS	VCL	0.935
SRC	LMNA	0.934
MAP2K1	VCL	0.934
IQGAP1	RAF1	0.934
BRAF	MAP2K2	0.933
BRAF	MAPK1	0.933
BRAF	IQGAP1	0.933
CNKSR1	BRAF	0.933
IQGAP1	KRAS	0.932
DIAPH1	IQGAP1	0.932
RHOA	PAFAH1B1	0.932
MAPK3	CSK	0.932
RAPGEF3	RAF1	0.932
PAFAH1B1	IQGAP1	0.932
HRAS	CSK	0.931
FN1	RAF1	0.931
FN1	IQGAP1	0.931
ILK	RAC1	0.931
RAP1A	MAPK1	0.931
MAPK3	RAP1B	0.931
SRC	RAP1B	0.931
KSR1	RAF1	0.93
SRC	KDR	0.93
ARAF	MAPK1	0.93
RAC1	CTNNB1	0.93
ARAF	MAPK3	0.93
CTNNA1	VCL	0.929
LMNA	MAP2K1	0.928
CSK	MAPK1	0.928
FN1	RAP1B	0.928
NRAS	FN1	0.928
RHOA	CDC42	0.928
CDC42	RAP1B	0.928
YWHAB	RAP1A	0.928
BRAF	MAPK3	0.928
RAP1A	MAP2K1	0.927
RAP1A	FN1	0.927
SRC	RAF1	0.927
SRC	MAP2K2	0.927
RAP1B	VCL	0.927
RHOA	CTNNA1	0.927
RAP1A	ARAF	0.926
RAP1B	MAPK1	0.926
CTNND1	RAP1B	0.926
CTNND1	RAP1A	0.926
VEGFA	IQGAP1	0.925
KRAS	CSK	0.925
PAFAH1B1	RAC1	0.925
RHOA	RAP1A	0.924
CDC42	RAP1A	0.924
RHOA	KRAS	0.924
ARRB1	KRAS	0.924
HRAS	RHOA	0.924
HRAS	YWHAB	0.924
YWHAB	MAPK3	0.923
CLIP1	RAC1	0.923
AKAP5	IQGAP1	0.923
CNKSR1	SRC	0.923
KIRREL	IQGAP1	0.923
LMNA	KRAS	0.923
CDC42	CTNNA1	0.922
KSR1	ARAF	0.922
KSR1	BRAF	0.922
RAP1A	BRAF	0.922
SRC	YWHAB	0.922
MAP2K1	CSK	0.921
RHOA	NRAS	0.921
ARRB1	FN1	0.921
RAP1A	CTNNB1	0.921
ARAF	RAP1B	0.921
RAP1A	MAP2K2	0.921
ESRP1	FN1	0.921
CNKSR1	MAP2K2	0.92
FN1	MAP2K2	0.92
MAP2K1	RAP1B	0.92
SRC	CSK	0.92
ESRP1	RAF1	0.92
ARRB1	RAF1	0.92
NRAS	IQGAP1	0.92
RAC1	TLN1	0.92
ARRB1	YWHAB	0.92
ARRB1	CSK	0.92
CTNNB1	RAP1B	0.92
MEN1	CDH1	0.92
CDH5	CDH1	0.92
ARRB1	HRAS	0.919
ESRP1	BRAF	0.919
CDH5	CTNNA1	0.919
YWHAB	MAPK1	0.919
RAC1	KDR	0.919
SRC	CTNNA1	0.919
MEN1	IQGAP1	0.918
NRAS	VCL	0.918
MAP2K2	CSK	0.918
MAP2K2	RAP1B	0.918
CNKSR1	ARAF	0.918
RAP1A	CDH1	0.918
AKAP5	ITPR1	0.917
HRAS	RAC1	0.917
YWHAB	CTNNB1	0.917
NRAS	CSK	0.917
FN1	IL17RD	0.917
YWHAB	MAP2K1	0.917
RAF1	VCL	0.917
BRAF	RAP1B	0.917
HRAS	CNKSR1	0.916
RAP1A	RAP1B	0.916
SRC	BRAF	0.916
ARAF	IQGAP1	0.916
KSR1	SRC	0.916
HRAS	ESRP1	0.916
TLN1	MAPK3	0.916
HRAS	TLN1	0.916
YWHAB	RAP1B	0.916
RAC1	KRAS	0.916
TLN1	MAPK1	0.916
ARRB1	IQGAP1	0.915
CTNNA1	RAP1B	0.915
YWHAB	LMNA	0.915
SRC	ARAF	0.915
NRAS	RAC1	0.915
YWHAB	MAP2K2	0.915
NRAS	LMNA	0.914
ITPR2	IQGAP1	0.914
CNKSR1	IQGAP1	0.914
VEGFA	CTNNA1	0.913
RHOA	RAC1	0.913
IQGAP1	PAPSS1	0.913
YWHAB	NRAS	0.913
TLN1	CSK	0.913
YWHAB	KRAS	0.913
CDH1	RAP1B	0.913
ESRP1	IQGAP1	0.913
ESRP1	KRAS	0.913
CNKSR1	MAPK3	0.913
YWHAB	IQGAP1	0.913
IL17RD	IQGAP1	0.912
CNKSR1	MAP2K1	0.912
FN1	BRAF	0.912
CNKSR1	KRAS	0.912
IQGAP1	CSK	0.911
ESRP1	SRC	0.911
MPRIP	TLN1	0.911
2002-09-01T00:00:00	PAFAH1B1	0.911
CNKSR1	MAPK1	0.911
MAP2K2	VCL	0.91
AKAP5	ITPR3	0.91
RAPGEF3	IQGAP1	0.91
ITPR3	IQGAP1	0.91
LMNA	TLN1	0.91
ITPR1	IQGAP1	0.91
MPRIP	SRC	0.909
KSR1	FN1	0.909
KSR1	RAP1B	0.909
MPRIP	IQGAP1	0.909
MPRIP	LMNA	0.909
ARRB1	KSR1	0.908
RAP1A	CTNNA1	0.908
LMNA	IQGAP1	0.908
YWHAB	FN1	0.908
MPRIP	VCL	0.908
RAP1A	CSK	0.908
YWHAB	ARAF	0.907
KDR	CSK	0.907
RAP1A	NRAS	0.907
ARAF	CSK	0.907
MPRIP	MAPK3	0.907
LMNA	MAP2K2	0.907
FN1	ARAF	0.907
CTNNA1	KDR	0.907
NRAS	PAPSS1	0.907
HRAS	RAP1B	0.907
RAF1	CSK	0.907
ESRP1	MAPK3	0.907
HRAS	RAP1A	0.907
LMNA	RAF1	0.906
HRAS	PAPSS1	0.906
ARRB1	RAP1A	0.906
IL17RD	MAPK1	0.906
ESRP1	CNKSR1	0.906
KRAS	RAP1B	0.906
RAP1A	KRAS	0.906
NRAS	RAP1B	0.906
MPRIP	KRAS	0.906
YWHAB	VCL	0.906
HRAS	MPRIP	0.906
MAP2K1	PAPSS1	0.906
CDC42	RAC1	0.906
RAP1B	CSK	0.905
RAC1	CTNNA1	0.905
ARRB1	VCL	0.905
CNKSR1	NRAS	0.905
ESRP1	MAP2K1	0.905
MEN1	CTNNA1	0.905
ESRP1	ARAF	0.905
ARAF	RAF1	0.905
BRAF	VCL	0.905
TLN1	KRAS	0.905
ITPR2	ITPR1	0.905
NRAS	KRAS	0.904
BRAF	RAF1	0.904
ITPR3	ITPR1	0.904
ESRP1	VCL	0.904
IL17RD	MAPK3	0.904
FN1	MEN1	0.904
ARRB1	TLN1	0.904
TLN1	MAP2K1	0.904
MPRIP	FN1	0.904
ARRB1	MAP2K2	0.904
ESRP1	MAPK1	0.903
PAPSS1	MAP2K2	0.903
IL17RD	BRAF	0.903
KSR1	RAP1A	0.903
ITPR2	ITPR3	0.903
BRAF	CSK	0.903
ARAF	BRAF	0.903
TLN1	ARAF	0.903
ESRP1	MPRIP	0.903
ARRB1	NRAS	0.903
CDC42	MEN1	0.902
HRAS	NRAS	0.902
MPRIP	NRAS	0.902
MAP2K1	MAP2K2	0.902
KSR1	CSK	0.902
MAPK3	MAPK1	0.902
PAPSS1	KRAS	0.902
KSR1	LMNA	0.902
HRAS	IL17RD	0.902
ARRB1	BRAF	0.902
PAPSS1	RAP1B	0.902
MPRIP	MAP2K1	0.902
RAP1A	PAPSS1	0.902
PAPSS1	CSK	0.902
ESRP1	YWHAB	0.902
YWHAB	PAPSS1	0.902
KSR1	VCL	0.902
IL17RD	KRAS	0.902
CNKSR1	VCL	0.902
SRC	PAPSS1	0.902
YWHAB	CSK	0.902
KSR1	YWHAB	0.902
ESRP1	NRAS	0.902
HRAS	KRAS	0.902
CNKSR1	FN1	0.902
IL17RD	RAF1	0.902
IL17RD	VCL	0.902
YWHAB	TLN1	0.902
CNKSR1	TLN1	0.902
ESRP1	LMNA	0.901
TLN1	PAPSS1	0.901
IL17RD	ARAF	0.901
FN1	PAPSS1	0.901
MAP2K1	IL17RD	0.901
ESRP1	PAPSS1	0.901
MPRIP	RAF1	0.901
LMNA	CSK	0.901
KSR1	IL17RD	0.901
NRAS	TLN1	0.901
MPRIP	YWHAB	0.901
ESRP1	KSR1	0.901
TLN1	MAP2K2	0.901
ARAF	VCL	0.901
LMNA	ARAF	0.901
MPRIP	MAPK1	0.901
PAPSS1	RAF1	0.9
MPRIP	PAPSS1	0.9
TLN1	BRAF	0.9
YWHAB	BRAF	0.9
ARRB1	ARAF	0.9
CNKSR1	PAPSS1	0.9
CNKSR1	IL17RD	0.9
ARRB1	PAPSS1	0.9
RAP1A	IL17RD	0.9
RAPGEF3	YWHAB	0.9
IL17RD	RAP1B	0.9
ARAF	PAPSS1	0.9
CNKSR1	LMNA	0.9
CNKSR1	YWHAB	0.9
ESRP1	TLN1	0.9
BRAF	PAPSS1	0.9
ESRP1	RAP1A	0.9
ARRB1	MPRIP	0.9
MPRIP	RAP1B	0.9
MPRIP	CNKSR1	0.9
MPRIP	BRAF	0.9
PAPSS1	VCL	0.9
ARRB1	LMNA	0.9
IL17RD	MAP2K2	0.9
ESRP1	CSK	0.9
TLN1	RAF1	0.9
MPRIP	MAP2K2	0.9
RAP1A	LMNA	0.9
RAC1	MEN1	0.9
AKAP5	ITPR2	0.9
MPRIP	CSK	0.9
TLN1	IL17RD	0.9
ESRP1	MAP2K2	0.9
CNKSR1	RAP1A	0.9
KSR1	PAPSS1	0.9
ARRB1	ESRP1	0.9
MPRIP	RAP1A	0.9
YWHAB	IL17RD	0.9
LMNA	BRAF	0.9
ARRB1	RAP1B	0.9
ARRB1	CNKSR1	0.9
MPRIP	ARAF	0.9
CNKSR1	CSK	0.9
IL17RD	CSK	0.9
PAPSS1	MAPK3	0.9
KSR1	MPRIP	0.9
LMNA	RAP1B	0.9
KSR1	TLN1	0.9
NRAS	IL17RD	0.9
ESRP1	RAP1B	0.9
CNKSR1	RAP1B	0.9
PAPSS1	MAPK1	0.9
SRC	IL17RD	0.9
ARRB1	IL17RD	0.9
LMNA	PAPSS1	0.9

Gene Ontology Semantic Similarity

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#	7422 (VEGFA)	1499 (CTNNB1)	1003 (CDH5)	1500 (CTNND1)	6249 (CLIP1)	998 (CDC42)	3265 (HRAS)	6714 (SRC)	7094 (TLN1)	673 (BRAF)	8844 (KSR1)	2335 (FN1)	387 (RHOA)	4893 (NRAS)	999 (CDH1)	5595 (MAPK3)	5604 (MAP2K1)	8826 (IQGAP1)	3845 (KRAS)	5605 (MAP2K2)	3611 (ILK)	408 (ARRB1)	10411 (RAPGEF3)	23265 (EXOC7)	369 (ARAF)	4868 (NPHS1)	5879 (RAC1)	10256 (CNKSR1)	5906 (RAP1A)	1495 (CTNNA1)	4000 (LMNA)	5594 (MAPK1)	1445 (CSK)	7529 (YWHAB)	5894 (RAF1)	1729 (DIAPH1)	5048 (PAFAH1B1)	5908 (RAP1B)	9495 (AKAP5)	55243 (KIRREL)	54845 (ESRP1)	4221 (MEN1)	3709 (ITPR2)	54756 (IL17RD)	23164 (MPRIP)	3710 (ITPR3)	3708 (ITPR1)	3791 (KDR)	9061 (PAPSS1)	7414 (VCL)
7422 (VEGFA)	1.00	0.64	0.72	0.69	0.63	0.59	0.59	0.64	0.62	0.60	0.63	0.72	0.59	0.62	0.71	0.60	0.56	0.59	0.62	0.56	0.60	0.60	0.60	1.00	0.58	0.63	0.59	0.63	0.59	0.67	1.00	0.58	0.62	0.68	0.61	0.68	0.68	0.58	0.65	0.63	0.61	0.56	0.47	0.19	0.63	0.55	0.53	0.59	0.43	0.65
1499 (CTNNB1)	0.64	1.00	0.74	0.74	0.64	0.63	0.64	0.69	0.69	0.63	0.71	0.70	0.65	0.71	0.72	0.64	0.61	0.68	0.71	0.60	0.68	0.67	0.65	1.00	0.63	0.69	0.67	0.69	0.66	0.71	1.00	0.62	0.67	0.75	0.66	0.71	0.65	0.64	0.71	0.69	0.67	0.65	0.49	0.13	0.72	0.57	0.56	0.61	0.38	0.74
1003 (CDH5)	0.72	0.74	1.00	0.86	0.82	0.62	0.63	0.68	0.76	0.75	0.74	0.70	0.67	0.75	0.94	0.64	0.59	0.71	0.75	0.60	0.70	0.67	0.68	1.00	0.65	0.78	0.63	0.76	0.66	0.83	1.00	0.61	0.68	0.79	0.65	0.80	0.72	0.61	0.75	0.78	0.72	0.60	0.58	0.13	0.82	0.63	0.60	0.62	0.47	0.82
1500 (CTNND1)	0.69	0.74	0.86	1.00	0.65	0.58	0.60	0.67	0.79	0.62	0.79	0.70	0.63	0.82	0.81	0.61	0.55	0.64	0.82	0.55	0.71	0.66	0.68	1.00	0.63	0.84	0.61	0.84	0.64	0.83	1.00	0.56	0.66	0.83	0.62	0.84	0.64	0.57	0.77	0.84	0.76	0.57	0.45	0.13	0.96	0.48	0.45	0.59	0.37	0.84
6249 (CLIP1)	0.63	0.64	0.82	0.65	1.00	0.54	0.53	0.58	0.61	0.65	0.63	0.63	0.55	0.62	0.82	0.55	0.51	0.62	0.62	0.50	0.57	0.57	0.57	1.00	0.53	0.64	0.55	0.64	0.54	0.67	1.00	0.51	0.58	0.68	0.56	0.64	0.75	0.51	0.66	0.64	0.59	0.53	0.52	0.13	0.63	0.55	0.52	0.54	0.41	0.66
998 (CDC42)	0.59	0.63	0.62	0.58	0.54	1.00	0.76	0.71	0.55	0.69	0.56	0.61	0.78	0.54	0.65	0.71	0.68	0.57	0.54	0.65	0.72	0.53	0.53	1.00	0.68	0.55	0.88	0.55	0.50	0.62	1.00	0.72	0.71	0.66	0.75	0.58	0.57	0.74	0.61	0.55	0.52	0.51	0.39	0.13	0.55	0.44	0.42	0.63	0.46	0.60
3265 (HRAS)	0.59	0.64	0.63	0.60	0.53	0.76	1.00	0.57	0.55	0.47	0.61	0.62	0.90	0.55	0.66	0.48	0.48	0.53	0.55	0.44	0.50	0.53	0.50	1.00	0.44	0.57	0.82	0.57	0.47	0.64	1.00	0.45	0.56	0.65	0.49	0.60	0.58	0.94	0.63	0.57	0.52	0.49	0.39	0.13	0.57	0.42	0.39	0.48	0.29	0.63
6714 (SRC)	0.64	0.69	0.68	0.67	0.58	0.71	0.57	1.00	0.65	0.76	0.62	0.68	0.58	0.59	0.66	0.77	0.78	0.61	0.59	0.74	0.75	0.60	0.58	1.00	0.77	0.60	0.73	0.61	0.56	0.65	1.00	0.77	0.80	0.69	0.81	0.67	0.61	0.55	0.66	0.60	0.59	0.59	0.45	0.13	0.63	0.51	0.49	0.76	0.53	0.65
7094 (TLN1)	0.62	0.69	0.76	0.79	0.61	0.55	0.55	0.65	1.00	0.57	0.68	0.72	0.58	0.68	0.77	0.56	0.53	0.63	0.68	0.53	0.62	0.60	0.63	1.00	0.57	0.69	0.57	0.69	0.58	0.79	1.00	0.53	0.61	0.76	0.58	0.70	0.62	0.53	0.70	0.69	0.64	0.55	0.43	0.13	0.77	0.47	0.45	0.61	0.34	0.75
673 (BRAF)	0.60	0.63	0.75	0.62	0.65	0.69	0.47	0.76	0.57	1.00	0.59	0.60	0.50	0.58	0.78	0.86	0.81	0.60	0.58	0.77	0.83	0.54	0.52	1.00	0.90	0.59	0.70	0.59	0.49	0.67	1.00	0.86	0.82	0.68	0.90	0.60	0.57	0.45	0.64	0.59	0.53	0.50	0.49	0.13	0.59	0.50	0.47	0.73	0.61	0.64
8844 (KSR1)	0.63	0.71	0.74	0.79	0.63	0.56	0.61	0.62	0.68	0.59	1.00	0.68	0.62	0.77	0.75	0.58	0.56	0.60	0.77	0.53	0.68	0.62	0.64	1.00	0.59	0.79	0.60	0.80	0.61	0.74	1.00	0.53	0.68	0.76	0.60	0.75	0.62	0.54	0.74	0.79	0.71	0.56	0.43	0.13	0.79	0.46	0.42	0.56	0.35	0.75
2335 (FN1)	0.72	0.70	0.70	0.70	0.63	0.61	0.62	0.68	0.72	0.60	0.68	1.00	0.61	0.65	0.71	0.61	0.57	0.61	0.65	0.55	0.62	0.62	0.61	1.00	0.58	0.65	0.63	0.66	0.59	0.69	1.00	0.58	0.65	0.73	0.64	0.68	0.71	0.58	0.71	0.65	0.63	0.57	0.47	0.13	0.66	0.55	0.51	0.63	0.38	0.68
387 (RHOA)	0.59	0.65	0.67	0.63	0.55	0.78	0.90	0.58	0.58	0.50	0.62	0.61	1.00	0.59	0.69	0.51	0.48	0.59	0.59	0.47	0.64	0.55	0.54	1.00	0.48	0.70	0.85	0.61	0.51	0.66	1.00	0.47	0.60	0.68	0.53	0.63	0.59	0.88	0.65	0.70	0.56	0.51	0.39	0.13	0.61	0.43	0.40	0.50	0.30	0.65
4893 (NRAS)	0.62	0.71	0.75	0.82	0.62	0.54	0.55	0.59	0.68	0.58	0.77	0.65	0.59	1.00	0.76	0.57	0.52	0.58	1.00	0.51	0.66	0.61	0.64	1.00	0.57	0.82	0.58	0.83	0.73	0.75	1.00	0.52	0.63	0.76	0.58	0.76	0.62	0.64	0.73	0.82	0.72	0.59	0.41	0.13	0.82	0.44	0.40	0.55	0.34	0.76
999 (CDH1)	0.71	0.72	0.94	0.81	0.82	0.65	0.66	0.66	0.77	0.78	0.75	0.71	0.69	0.76	1.00	0.69	0.62	0.72	0.76	0.63	0.71	0.67	0.70	1.00	0.68	0.78	0.66	0.77	0.68	0.86	1.00	0.66	0.72	0.81	0.70	0.75	0.73	0.64	0.73	0.78	0.73	0.63	0.59	0.13	0.81	0.65	0.63	0.66	0.49	0.82
5595 (MAPK3)	0.60	0.64	0.64	0.61	0.55	0.71	0.48	0.77	0.56	0.86	0.58	0.61	0.51	0.57	0.69	1.00	0.79	0.55	0.57	0.77	0.84	0.54	0.52	1.00	0.88	0.58	0.73	0.58	0.49	0.65	1.00	0.99	0.85	0.68	0.94	0.59	0.57	0.46	0.65	0.58	0.53	0.51	0.38	0.15	0.58	0.43	0.40	0.71	0.65	0.63
5604 (MAP2K1)	0.56	0.61	0.59	0.55	0.51	0.68	0.48	0.78	0.53	0.81	0.56	0.57	0.48	0.52	0.62	0.79	1.00	0.61	0.52	0.95	0.79	0.55	0.50	1.00	0.85	0.53	0.70	0.53	0.47	0.58	1.00	0.80	0.79	0.60	0.84	0.55	0.53	0.44	0.62	0.53	0.49	0.51	0.40	0.17	0.53	0.42	0.40	0.70	0.55	0.58
8826 (IQGAP1)	0.59	0.68	0.71	0.64	0.62	0.57	0.53	0.61	0.63	0.60	0.60	0.61	0.59	0.58	0.72	0.55	0.61	1.00	0.58	0.62	0.60	0.69	0.61	1.00	0.53	0.59	0.59	0.59	0.55	0.64	1.00	0.53	0.58	0.69	0.56	0.60	0.57	0.52	0.68	0.59	0.56	0.53	0.54	0.13	0.63	0.59	0.57	0.53	0.32	0.65
3845 (KRAS)	0.62	0.71	0.75	0.82	0.62	0.54	0.55	0.59	0.68	0.58	0.77	0.65	0.59	1.00	0.76	0.57	0.52	0.58	1.00	0.51	0.66	0.61	0.64	1.00	0.57	0.82	0.58	0.83	0.73	0.75	1.00	0.52	0.63	0.76	0.58	0.76	0.62	0.64	0.73	0.82	0.72	0.59	0.41	0.13	0.82	0.44	0.40	0.55	0.34	0.76
5605 (MAP2K2)	0.56	0.60	0.60	0.55	0.50	0.65	0.44	0.74	0.53	0.77	0.53	0.55	0.47	0.51	0.63	0.77	0.95	0.62	0.51	1.00	0.76	0.55	0.51	1.00	0.81	0.52	0.67	0.52	0.46	0.59	1.00	0.78	0.73	0.62	0.80	0.55	0.52	0.42	0.63	0.52	0.48	0.48	0.40	0.17	0.52	0.41	0.38	0.66	0.51	0.59
3611 (ILK)	0.60	0.68	0.70	0.71	0.57	0.72	0.50	0.75	0.62	0.83	0.68	0.62	0.64	0.66	0.71	0.84	0.79	0.60	0.66	0.76	1.00	0.57	0.57	1.00	0.92	0.68	0.77	0.69	0.53	0.69	1.00	0.84	0.83	0.72	0.88	0.68	0.58	0.47	0.69	0.68	0.61	0.52	0.38	0.13	0.68	0.41	0.38	0.68	0.54	0.70
408 (ARRB1)	0.60	0.67	0.67	0.66	0.57	0.53	0.53	0.60	0.60	0.54	0.62	0.62	0.55	0.61	0.67	0.54	0.55	0.69	0.61	0.55	0.57	1.00	0.63	1.00	0.54	0.62	0.56	0.62	0.58	0.68	1.00	0.51	0.57	0.67	0.56	0.69	0.58	0.52	0.66	0.62	0.61	0.65	0.41	0.13	0.62	0.47	0.46	0.54	0.32	0.70
10411 (RAPGEF3)	0.60	0.65	0.68	0.68	0.57	0.53	0.50	0.58	0.63	0.52	0.64	0.61	0.54	0.64	0.70	0.52	0.50	0.61	0.64	0.51	0.57	0.63	1.00	1.00	0.50	0.66	0.54	0.66	0.79	0.68	1.00	0.48	0.57	0.72	0.53	0.66	0.58	0.48	0.69	0.66	0.59	0.51	0.38	0.13	0.66	0.42	0.41	0.52	0.31	0.68
23265 (EXOC7)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	0.13	1.00	1.00	1.00	1.00	0.61	1.00
369 (ARAF)	0.58	0.63	0.65	0.63	0.53	0.68	0.44	0.77	0.57	0.90	0.59	0.58	0.48	0.57	0.68	0.88	0.85	0.53	0.57	0.81	0.92	0.54	0.50	1.00	1.00	0.59	0.73	0.60	0.47	0.65	1.00	0.88	0.83	0.66	0.93	0.61	0.55	0.41	0.65	0.59	0.51	0.49	0.34	0.13	0.59	0.37	0.33	0.72	0.62	0.65
4868 (NPHS1)	0.63	0.69	0.78	0.84	0.64	0.55	0.57	0.60	0.69	0.59	0.79	0.65	0.70	0.82	0.78	0.58	0.53	0.59	0.82	0.52	0.68	0.62	0.66	1.00	0.59	1.00	0.59	0.85	0.61	0.77	1.00	0.53	0.64	0.77	0.60	0.78	0.63	0.53	0.74	1.00	0.75	0.55	0.42	0.13	0.85	0.45	0.41	0.56	0.35	0.77
5879 (RAC1)	0.59	0.67	0.63	0.61	0.55	0.88	0.82	0.73	0.57	0.70	0.60	0.63	0.85	0.58	0.66	0.73	0.70	0.59	0.58	0.67	0.77	0.56	0.54	1.00	0.73	0.59	1.00	0.59	0.52	0.63	1.00	0.74	0.72	0.70	0.79	0.61	0.59	0.80	0.65	0.59	0.55	0.52	0.40	0.13	0.59	0.45	0.42	0.63	0.45	0.64
10256 (CNKSR1)	0.63	0.69	0.76	0.84	0.64	0.55	0.57	0.61	0.69	0.59	0.80	0.66	0.61	0.83	0.77	0.58	0.53	0.59	0.83	0.52	0.69	0.62	0.66	1.00	0.60	0.85	0.59	1.00	0.62	0.77	1.00	0.53	0.65	0.77	0.60	0.78	0.63	0.54	0.74	0.85	0.75	0.60	0.43	0.13	0.85	0.45	0.41	0.56	0.35	0.77
5906 (RAP1A)	0.59	0.66	0.66	0.64	0.54	0.50	0.47	0.56	0.58	0.49	0.61	0.59	0.51	0.73	0.68	0.49	0.47	0.55	0.73	0.46	0.53	0.58	0.79	1.00	0.47	0.61	0.52	0.62	1.00	0.65	1.00	0.46	0.54	0.67	0.51	0.62	0.56	0.54	0.66	0.61	0.55	0.54	0.41	0.13	0.61	0.42	0.42	0.50	0.29	0.66
1495 (CTNNA1)	0.67	0.71	0.83	0.83	0.67	0.62	0.64	0.65	0.79	0.67	0.74	0.69	0.66	0.75	0.86	0.65	0.58	0.64	0.75	0.59	0.69	0.68	0.68	1.00	0.65	0.77	0.63	0.77	0.65	1.00	1.00	0.62	0.69	0.81	0.67	0.86	0.66	0.62	0.73	0.77	0.82	0.68	0.48	0.13	0.83	0.53	0.51	0.62	0.42	0.82
4000 (LMNA)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	0.13	1.00	1.00	1.00	1.00	0.61	1.00
5594 (MAPK1)	0.58	0.62	0.61	0.56	0.51	0.72	0.45	0.77	0.53	0.86	0.53	0.58	0.47	0.52	0.66	0.99	0.80	0.53	0.52	0.78	0.84	0.51	0.48	1.00	0.88	0.53	0.74	0.53	0.46	0.62	1.00	1.00	0.84	0.64	0.94	0.55	0.54	0.43	0.62	0.53	0.48	0.49	0.36	0.15	0.53	0.41	0.38	0.71	0.64	0.59
1445 (CSK)	0.62	0.67	0.68	0.66	0.58	0.71	0.56	0.80	0.61	0.82	0.68	0.65	0.60	0.63	0.72	0.85	0.79	0.58	0.63	0.73	0.83	0.57	0.57	1.00	0.83	0.64	0.72	0.65	0.54	0.69	1.00	0.84	1.00	0.71	0.90	0.65	0.60	0.51	0.67	0.64	0.59	0.54	0.40	0.13	0.64	0.45	0.42	0.76	0.63	0.67
7529 (YWHAB)	0.68	0.75	0.79	0.83	0.68	0.66	0.65	0.69	0.76	0.68	0.76	0.73	0.68	0.76	0.81	0.68	0.60	0.69	0.76	0.62	0.72	0.67	0.72	1.00	0.66	0.77	0.70	0.77	0.67	0.81	1.00	0.64	0.71	1.00	0.71	0.75	0.71	0.63	0.76	0.77	0.73	0.61	0.51	0.13	0.83	0.58	0.54	0.63	0.43	0.80
5894 (RAF1)	0.61	0.66	0.65	0.62	0.56	0.75	0.49	0.81	0.58	0.90	0.60	0.64	0.53	0.58	0.70	0.94	0.84	0.56	0.58	0.80	0.88	0.56	0.53	1.00	0.93	0.60	0.79	0.60	0.51	0.67	1.00	0.94	0.90	0.71	1.00	0.61	0.58	0.47	0.66	0.60	0.55	0.52	0.38	0.13	0.60	0.42	0.39	0.75	0.68	0.65
1729 (DIAPH1)	0.68	0.71	0.80	0.84	0.64	0.58	0.60	0.67	0.70	0.60	0.75	0.68	0.63	0.76	0.75	0.59	0.55	0.60	0.76	0.55	0.68	0.69	0.66	1.00	0.61	0.78	0.61	0.78	0.62	0.86	1.00	0.55	0.65	0.75	0.61	1.00	0.63	0.58	0.75	0.78	0.87	0.67	0.44	0.13	0.78	0.48	0.45	0.58	0.36	0.75
5048 (PAFAH1B1)	0.68	0.65	0.72	0.64	0.75	0.57	0.58	0.61	0.62	0.57	0.62	0.71	0.59	0.62	0.73	0.57	0.53	0.57	0.62	0.52	0.58	0.58	0.58	1.00	0.55	0.63	0.59	0.63	0.56	0.66	1.00	0.54	0.60	0.71	0.58	0.63	1.00	0.56	0.65	0.63	0.60	0.54	0.45	0.13	0.63	0.52	0.48	0.56	0.42	0.66
5908 (RAP1B)	0.58	0.64	0.61	0.57	0.51	0.74	0.94	0.55	0.53	0.45	0.54	0.58	0.88	0.64	0.64	0.46	0.44	0.52	0.64	0.42	0.47	0.52	0.48	1.00	0.41	0.53	0.80	0.54	0.54	0.62	1.00	0.43	0.51	0.63	0.47	0.58	0.56	1.00	0.62	0.53	0.49	0.51	0.37	0.13	0.53	0.41	0.37	0.47	0.27	0.61
9495 (AKAP5)	0.65	0.71	0.75	0.77	0.66	0.61	0.63	0.66	0.70	0.64	0.74	0.71	0.65	0.73	0.73	0.65	0.62	0.68	0.73	0.63	0.69	0.66	0.69	1.00	0.65	0.74	0.65	0.74	0.66	0.73	1.00	0.62	0.67	0.76	0.66	0.75	0.65	0.62	1.00	0.74	0.71	0.61	0.52	0.13	0.74	0.56	0.54	0.61	0.39	0.73
55243 (KIRREL)	0.63	0.69	0.78	0.84	0.64	0.55	0.57	0.60	0.69	0.59	0.79	0.65	0.70	0.82	0.78	0.58	0.53	0.59	0.82	0.52	0.68	0.62	0.66	1.00	0.59	1.00	0.59	0.85	0.61	0.77	1.00	0.53	0.64	0.77	0.60	0.78	0.63	0.53	0.74	1.00	0.75	0.55	0.42	0.13	0.85	0.45	0.41	0.56	0.35	0.77
54845 (ESRP1)	0.61	0.67	0.72	0.76	0.59	0.52	0.52	0.59	0.64	0.53	0.71	0.63	0.56	0.72	0.73	0.53	0.49	0.56	0.72	0.48	0.61	0.61	0.59	1.00	0.51	0.75	0.55	0.75	0.55	0.82	1.00	0.48	0.59	0.73	0.55	0.87	0.60	0.49	0.71	0.75	1.00	0.58	0.38	0.13	0.75	0.41	0.37	0.52	0.31	0.73
4221 (MEN1)	0.56	0.65	0.60	0.57	0.53	0.51	0.49	0.59	0.55	0.50	0.56	0.57	0.51	0.59	0.63	0.51	0.51	0.53	0.59	0.48	0.52	0.65	0.51	1.00	0.49	0.55	0.52	0.60	0.54	0.68	1.00	0.49	0.54	0.61	0.52	0.67	0.54	0.51	0.61	0.55	0.58	1.00	0.38	0.13	0.55	0.43	0.41	0.50	0.31	0.60
3709 (ITPR2)	0.47	0.49	0.58	0.45	0.52	0.39	0.39	0.45	0.43	0.49	0.43	0.47	0.39	0.41	0.59	0.38	0.40	0.54	0.41	0.40	0.38	0.41	0.38	0.82	0.34	0.42	0.40	0.43	0.41	0.48	0.82	0.36	0.40	0.51	0.38	0.44	0.45	0.37	0.52	0.42	0.38	0.38	1.00	0.34	0.42	0.90	0.91	0.45	0.21	0.48
54756 (IL17RD)	0.19	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.15	0.17	0.13	0.13	0.17	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.15	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.34	1.00	0.13	0.34	0.34	0.82	0.09	0.13
23164 (MPRIP)	0.63	0.72	0.82	0.96	0.63	0.55	0.57	0.63	0.77	0.59	0.79	0.66	0.61	0.82	0.81	0.58	0.53	0.63	0.82	0.52	0.68	0.62	0.66	1.00	0.59	0.85	0.59	0.85	0.61	0.83	1.00	0.53	0.64	0.83	0.60	0.78	0.63	0.53	0.74	0.85	0.75	0.55	0.42	0.13	1.00	0.45	0.41	0.56	0.35	0.84
3710 (ITPR3)	0.55	0.57	0.63	0.48	0.55	0.44	0.42	0.51	0.47	0.50	0.46	0.55	0.43	0.44	0.65	0.43	0.42	0.59	0.44	0.41	0.41	0.47	0.42	1.00	0.37	0.45	0.45	0.45	0.42	0.53	1.00	0.41	0.45	0.58	0.42	0.48	0.52	0.41	0.56	0.45	0.41	0.43	0.90	0.34	0.45	1.00	0.89	0.51	0.23	0.54
3708 (ITPR1)	0.53	0.56	0.60	0.45	0.52	0.42	0.39	0.49	0.45	0.47	0.42	0.51	0.40	0.40	0.63	0.40	0.40	0.57	0.40	0.38	0.38	0.46	0.41	1.00	0.33	0.41	0.42	0.41	0.42	0.51	1.00	0.38	0.42	0.54	0.39	0.45	0.48	0.37	0.54	0.41	0.37	0.41	0.91	0.34	0.41	0.89	1.00	0.49	0.21	0.51
3791 (KDR)	0.59	0.61	0.62	0.59	0.54	0.63	0.48	0.76	0.61	0.73	0.56	0.63	0.50	0.55	0.66	0.71	0.70	0.53	0.55	0.66	0.68	0.54	0.52	1.00	0.72	0.56	0.63	0.56	0.50	0.62	1.00	0.71	0.76	0.63	0.75	0.58	0.56	0.47	0.61	0.56	0.52	0.50	0.45	0.82	0.56	0.51	0.49	1.00	0.50	0.60
9061 (PAPSS1)	0.43	0.38	0.47	0.37	0.41	0.46	0.29	0.53	0.34	0.61	0.35	0.38	0.30	0.34	0.49	0.65	0.55	0.32	0.34	0.51	0.54	0.32	0.31	0.61	0.62	0.35	0.45	0.35	0.29	0.42	0.61	0.64	0.63	0.43	0.68	0.36	0.42	0.27	0.39	0.35	0.31	0.31	0.21	0.09	0.35	0.23	0.21	0.50	1.00	0.38
7414 (VCL)	0.65	0.74	0.82	0.84	0.66	0.60	0.63	0.65	0.75	0.64	0.75	0.68	0.65	0.76	0.82	0.63	0.58	0.65	0.76	0.59	0.70	0.70	0.68	1.00	0.65	0.77	0.64	0.77	0.66	0.82	1.00	0.59	0.67	0.80	0.65	0.75	0.66	0.61	0.73	0.77	0.73	0.60	0.48	0.13	0.84	0.54	0.51	0.60	0.38	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
IQGAP1	Human	Blood	-	3600 m	Native	upregulated	-	TMT-based proteomic analysis/LC-MS	Central Asia	Tibetans	-	High altitude native vs. low Lander	30908922

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
STAT3	6774	IQGAP1	8826	proximal_filtered	22955619	TRANSFAC

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT002697	hsa-miR-124-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	19843643
MIRT002697	hsa-miR-124-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	Luciferase reporter assay//Microarray	Functional MTI	15685193
MIRT002697	hsa-miR-124-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	Immunoblot//Immunohistochemistry//qRT-PCR//Western blot	Functional MTI	21196113
MIRT002697	hsa-miR-124-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	Microarray	Functional MTI (Weak)	18668037
MIRT002697	hsa-miR-124-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	Luciferase reporter assay	Functional MTI	26934121
MIRT024313	hsa-miR-215-5p	Homo sapiens	IQGAP1	8826	Homo sapiens	Microarray	Functional MTI (Weak)	19074876
MIRT026798	hsa-miR-192-5p	Homo sapiens	IQGAP1	8826	Homo sapiens	Microarray	Functional MTI (Weak)	19074876
MIRT042850	hsa-miR-324-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT049578	hsa-miR-92a-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT440432	hsa-miR-376a-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	24374217
MIRT440433	hsa-miR-544a	Homo sapiens	IQGAP1	8826	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	24374217
MIRT724398	hsa-miR-449b-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT724396	hsa-miR-136-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT724397	hsa-miR-3074-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT733787	hsa-miR-506-3p	Homo sapiens	IQGAP1	8826	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26398880
MIRT734339	hsa-miR-506-5p	Homo sapiens	IQGAP1	8826	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26398880

Gene Ontology

ID	GO ID	GO Term	GO Type
8826	GO:0034260	negative regulation of GTPase activity	GOTERM_BP_DIRECT
8826	GO:0036120	cellular response to platelet-derived growth factor stimulus	GOTERM_BP_DIRECT
8826	GO:0030424	axon	GOTERM_CC_DIRECT
8826	GO:1900006	positive regulation of dendrite development	GOTERM_BP_DIRECT
8826	GO:0005829	cytosol	GOTERM_CC_DIRECT
8826	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GOTERM_CC_DIRECT
8826	GO:0005096	GTPase inhibitor activity	GOTERM_MF_DIRECT
8826	GO:0019903	phosphatase binding	GOTERM_MF_DIRECT
8826	GO:0005913	cell-cell adherens junction	GOTERM_CC_DIRECT
8826	GO:0043005	neuron projection	GOTERM_CC_DIRECT
8826	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
8826	GO:0001817	regulation of cytokine production	GOTERM_BP_DIRECT
8826	GO:0045860	positive regulation of protein kinase activity	GOTERM_BP_DIRECT
8826	GO:0043547	positive regulation of GTPase activity	GOTERM_BP_DIRECT
8826	GO:0005547	1-phosphatidylinositol binding	GOTERM_MF_DIRECT
8826	GO:0032403	phosphatidylinositol-3-phosphate binding	GOTERM_MF_DIRECT
8826	GO:0051019	actin filament binding	GOTERM_MF_DIRECT
8826	GO:0005634	nucleus	GOTERM_CC_DIRECT
8826	GO:0072015	glomerular visceral epithelial cell development	GOTERM_BP_DIRECT
8826	GO:1903829	positive regulation of cellular protein localization	GOTERM_BP_DIRECT
8826	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GOTERM_BP_DIRECT
8826	GO:0005095	Rho guanyl-nucleotide exchange factor activity	GOTERM_MF_DIRECT
8826	GO:0015629	actin cytoskeleton	GOTERM_CC_DIRECT
8826	GO:0030496	midbody	GOTERM_CC_DIRECT
8826	GO:0045121	membrane raft	GOTERM_CC_DIRECT
8826	GO:0005516	protein binding	GOTERM_MF_DIRECT
8826	GO:0048365	calcium-dependent protein binding	GOTERM_MF_DIRECT
8826	GO:0019901	protein kinase binding	GOTERM_MF_DIRECT
8826	GO:0031252	cell leading edge	GOTERM_CC_DIRECT
8826	GO:0007165	signal transduction	GOTERM_BP_DIRECT
8826	GO:0008543	fibroblast growth factor receptor signaling pathway	GOTERM_BP_DIRECT
8826	GO:0071277	cellular response to calcium ion	GOTERM_BP_DIRECT
8826	GO:0005509	calcium ion binding	GOTERM_MF_DIRECT
8826	GO:0005884	actin filament	GOTERM_CC_DIRECT
8826	GO:0005911	cell-cell junction	GOTERM_CC_DIRECT
8826	GO:0016328	lateral plasma membrane	GOTERM_CC_DIRECT
8826	GO:0005925	focal adhesion	GOTERM_CC_DIRECT
8826	GO:0048008	platelet-derived growth factor receptor signaling pathway	GOTERM_BP_DIRECT
8826	GO:0019904	protein domain specific binding	GOTERM_MF_DIRECT
8826	GO:0098641	G-rich strand telomeric DNA binding	GOTERM_MF_DIRECT
8826	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
8826	GO:0030426	growth cone	GOTERM_CC_DIRECT
8826	GO:0036057	slit diaphragm	GOTERM_CC_DIRECT
8826	GO:0043087	regulation of GTPase activity	GOTERM_BP_DIRECT
8826	GO:0071364	cellular response to epidermal growth factor stimulus	GOTERM_BP_DIRECT
8826	GO:1990138	neuron projection extension	GOTERM_BP_DIRECT
8826	GO:0044548	ion channel binding	GOTERM_MF_DIRECT
8826	GO:0001726	ruffle	GOTERM_CC_DIRECT
8826	GO:0035305	negative regulation of dephosphorylation	GOTERM_BP_DIRECT
8826	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	GOTERM_BP_DIRECT
8826	GO:0043539	ADP binding	GOTERM_MF_DIRECT
8826	GO:0005874	microtubule	GOTERM_CC_DIRECT
8826	GO:0015630	microtubule cytoskeleton	GOTERM_CC_DIRECT
8826	GO:0030529	intracellular ribonucleoprotein complex	GOTERM_CC_DIRECT
8826	GO:0098609	cell-cell adhesion	GOTERM_BP_DIRECT
8826	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
8826	GO:0036464	cytoplasmic ribonucleoprotein granule	GOTERM_CC_DIRECT
8826	GO:0043234	protein complex	GOTERM_CC_DIRECT
8826	GO:0007173	epidermal growth factor receptor signaling pathway	GOTERM_BP_DIRECT
8826	GO:0043406	positive regulation of MAP kinase activity	GOTERM_BP_DIRECT
8826	GO:0051894	positive regulation of focal adhesion assembly	GOTERM_BP_DIRECT
8826	GO:1990776	response to angiotensin	GOTERM_BP_DIRECT
8826	GO:0005515	protein binding	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
8826	hsa04520	Adherens junction
8826	hsa04810	Regulation of actin cytoskeleton
8826	hsa05205	Proteoglycans in cancer

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
IQGAP1	8826	Brain Neoplasms	C0006118	Neoplastic Process	0.3	0.6	0.586	group
IQGAP1	8826	Liver carcinoma	C2239176	Neoplastic Process	0.34	0.6	0.586	disease
IQGAP1	8826	Brain Tumor, Primary	C0750974	Neoplastic Process	0.3	0.6	0.586	disease
IQGAP1	8826	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.6	0.586	disease
IQGAP1	8826	Benign neoplasm of brain, unspecified	C0496899	Neoplastic Process	0.3	0.6	0.586	disease
IQGAP1	8826	Recurrent Brain Neoplasm	C0750977	Neoplastic Process	0.3	0.6	0.586	disease
IQGAP1	8826	Malignant neoplasm of brain	C0153633	Neoplastic Process	0.3	0.6	0.586	disease
IQGAP1	8826	Primary malignant neoplasm of brain	C0750979	Neoplastic Process	0.3	0.6	0.586	disease
IQGAP1	8826	Neoplasms, Intracranial	C1527390	Neoplastic Process	0.3	0.6	0.586	group
IQGAP1	8826	Weight Gain	C0043094	Finding	0.3	0.6	0.586	phenotype

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types