SOS Ras/Rac guanine nucleotide exchange factor 1

AltitudeomicsDB
Protein Official symbol SOS1
Aliases SOS1
Chromosomal Location 2
Length 1333
Uniprot ID Q07889
EC number None
Protein family Information(Pfam) PF00125;PF00169;PF00617;PF00618;PF00621;
PDB id 1AWE;1BKD;1DBH;1NVU;1NVV;1NVW;1NVX;1Q9C;1XD2;1XD4;1XDV;2II0;3KSY;4NYI;4NYJ;4NYM;4URU;4URV;4URW;4URX;4URY;4URZ;4US0;4US1;4US2;5OVD;5OVE;5OVF;5OVG;5OVH;5OVI;5WFO;5WFP;5WFQ;5WFR;6BVI;6BVJ;6BVK;6BVL;6BVM;6CUO;6CUP;6CUR;6D55;6D56;6D59;6D5E;6D5G;6D5H;6D5J;6D5L;6D5M;6D5V;6D5W;6EPL;6EPM;6EPN;6EPO;6EPP;6F08;
InterPro ID IPR035899;IPR000219;IPR009072;IPR007125;IPR011993;IPR001849;IPR008937;IPR000651;IPR019804;IPR023578;IPR001895;IPR036964;
dbSNP rs150565592 rs1553362937 rs397517164 rs397517166 rs397517172 rs142094234 rs137852812 rs137852813 rs137852813 rs397517180 rs724160007 rs397517146 rs730881041 rs267607080 rs397517147 rs730881048 rs397517148 rs397517150 rs727504295 rs730881044 rs1553356111 rs1431574387 rs371314838 rs397517149 rs730881046 rs397517153 rs137852814 rs397517154 rs397517154 rs267607079 rs397517154 rs200786705 rs56219475 rs727505381 rs140811086 rs574088829 rs1335137808 rs397517159 rs1367714753 rs8192671 rs768113420 rs375550588 rs553805862

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SHC1 GRB2 0.9990000000000001
PTPN11 GAB1 0.9990000000000001
EGFR EGF 0.9990000000000001
HRAS SOS1 0.9990000000000001
GRB2 EGFR 0.9990000000000001
GRB2 CBL 0.9990000000000001
SOS1 GRB2 0.9990000000000001
EGFR CBL 0.998
SHC1 EGFR 0.998
HRAS EGFR 0.998
SRC FYN 0.998
GRAP2 LCP2 0.998
EGFR KRAS 0.998
VAV1 LCP2 0.997
ABI1 ABL1 0.997
FRS2 FGFR1 0.996
PTPN11 EGFR 0.996
GRB2 GAB1 0.996
ERBB2 EGF 0.996
EPS8 USP6NL 0.996
PTPN11 MAPK3 0.996
NRAS KRAS 0.996
HRAS NRAS 0.995
GRB2 ERBB2 0.995
HRAS KRAS 0.995
FYN CBL 0.995
LAT LCP2 0.9940000000000001
SHC1 CBL 0.9940000000000001
EGFR PLCG1 0.9940000000000001
GRB2 ERBB3 0.9940000000000001
ABI1 EPS8 0.9940000000000001
VAV1 RAC2 0.9940000000000001
PTPN11 ERBB2 0.9940000000000001
HRAS MAP2K1 0.9940000000000001
PIK3R1 EGFR 0.9940000000000001
SOS1 EPS8 0.993
GRB2 LCP2 0.993
SOS1 KRAS 0.993
LAT GRB2 0.992
PIK3R1 SHC1 0.992
CAV1 EGFR 0.992
SRC CAV1 0.992
FRS2 GRB2 0.992
SHC1 ERBB2 0.992
VAV1 LCK 0.992
FGFR1 PLCG1 0.992
AKT1 ERBB3 0.992
LAT PLCG1 0.992
SHC1 ERBB3 0.991
MAPK3 MAP2K2 0.991
MAP2K1 MAPK1 0.991
HRAS SRC 0.991
SOS1 EGFR 0.991
ERBB2 KRAS 0.991
MAP2K2 MAPK1 0.991
LAT LCK 0.991
HRAS ERBB2 0.991
MAP2K1 MAPK3 0.991
SRC EGF 0.99
AKT1 PIK3R1 0.99
VAV1 CDC42 0.99
SHC1 PIK3R2 0.99
PIK3R1 CBL 0.99
ERBB3 EGF 0.9890000000000001
VAV1 RAC3 0.9890000000000001
LCK LCP2 0.9890000000000001
GRB2 PTPN11 0.9890000000000001
SHC1 SOS1 0.9890000000000001
FRS2 PTPN11 0.9890000000000001
HRAS GRB2 0.9890000000000001
PIK3R1 ERBB2 0.988
EGFR ERBB3 0.988
SOS1 NRAS 0.988
SOS1 PTPN11 0.988
PTPN11 ERBB3 0.988
AKT1 GRB2 0.988
CDC42 RAP1A 0.988
CDC42 SRC 0.988
GRB2 MAPK1 0.988
NCK1 LCP2 0.987
VAV1 RAC1 0.987
MAPK3 MAPK1 0.987
AKT1 RHOA 0.987
PIK3R1 HRAS 0.987
PTPN11 MAPK1 0.987
LAT GRAP2 0.987
NRAS MAP2K1 0.986
EGFR GAB1 0.986
VAV2 RAC1 0.986
MAP2K1 KRAS 0.986
VAV2 RAC2 0.986
HRAS MAP2K2 0.986
MET CBL 0.986
GRB2 KRAS 0.985
PIK3R1 ERBB3 0.985
HRAS MAPK3 0.985
KRAS MAPK1 0.985
RET PLCG1 0.985
VAV1 LAT 0.985
VAV1 RHOA 0.985
FYN LCP2 0.985
RAC3 RAC2 0.985
VAV1 GRB2 0.985
SHC1 GRAP2 0.985
RHOA VAV2 0.985
PIK3R1 SRC 0.985
CDC42 VAV2 0.9840000000000001
SOS1 ABI1 0.9840000000000001
RHOA MAPK1 0.9840000000000001
SHC1 LCK 0.9840000000000001
VAV2 RAC3 0.9840000000000001
LAT FYN 0.9840000000000001
HRAS MAPK1 0.9840000000000001
GRB2 MAPK3 0.9840000000000001
PIK3R1 PIK3R2 0.983
MAPK3 KRAS 0.983
SRC CBL 0.983
FYN CAV1 0.983
GRB2 EGF 0.982
HRAS FYN 0.982
RAC1 RAC3 0.982
MAP2K1 MAP2K2 0.982
EPS8 EGFR 0.982
PIK3R1 SOS1 0.982
HRAS PTPN11 0.982
ERBB3 KRAS 0.982
SHC1 FYN 0.982
HRAS ERBB3 0.982
NRAS EGFR 0.982
LCK PLCG1 0.981
SRC GAB1 0.981
FGFR1 SOS1 0.981
SHC1 EGF 0.981
AKT1 CAV1 0.981
PIK3R1 FGFR1 0.981
AKT1 RAC1 0.981
PTPN11 MAP2K1 0.981
VAV2 RHOG 0.98
HRAS RET 0.98
NRAS MAP2K2 0.98
RHOA SRC 0.98
SHC1 MAPK1 0.98
NRAS PTPN11 0.98
AKT1 SHC1 0.98
MAP2K2 KRAS 0.98
SOS1 MAPK1 0.9790000000000001
NRAS MAPK3 0.9790000000000001
NCK1 CDC42 0.9790000000000001
VAV1 RHOG 0.9790000000000001
ABL1 BCR 0.9790000000000001
HCK PLCG1 0.9790000000000001
FRS2 SRC 0.978
RHOA MAPK3 0.978
GRB2 MAP2K1 0.978
LCK CBL 0.978
AKT1 SRC 0.978
CBL LCP2 0.978
SOS1 GAB1 0.977
HRAS EGF 0.977
GRB2 RET 0.977
NRAS MAPK1 0.977
SOS1 MAP2K2 0.977
VAV1 HCK 0.977
GRB2 NRAS 0.976
AKT1 PTPN11 0.976
PTPN11 KRAS 0.976
EGF KRAS 0.976
SOS1 MAP2K1 0.976
VAV1 CBL 0.976
SOS1 SRC 0.976
RET KRAS 0.975
PIK3R1 GRB2 0.975
NRAS ERBB2 0.975
GRB2 MET 0.975
HCK EGFR 0.975
HRAS FGFR1 0.975
SHC1 GAB1 0.975
PTPN11 CBL 0.975
SRC KRAS 0.975
HRAS MET 0.9740000000000001
MET KRAS 0.9740000000000001
RET PTPN11 0.973
LAT CBL 0.973
GRAP2 CBL 0.973
FRS2 RET 0.973
LAT2 LAT 0.973
HCK CBL 0.973
CAV1 EGF 0.973
NCK1 NCK2 0.973
MET GAB1 0.972
HCK SOS1 0.972
CBL PLCG1 0.972
CDC42 EGFR 0.972
NCK1 ABI1 0.972
SOS1 RAC1 0.972
PIK3R1 PTPN11 0.972
SOS1 RRAS 0.972
SHC1 MAPK3 0.972
GRB2 SRC 0.971
SHC1 MET 0.971
EGFR ERBB2 0.971
PTPN11 MET 0.971
ABI1 USP6NL 0.97
SHC1 SRC 0.97
LAT SRC 0.97
SOS1 MAPK3 0.9690000000000001
RHOA PTPN11 0.9690000000000001
PLCG1 LCP2 0.9690000000000001
LAT2 GRB2 0.9690000000000001
FGFR1 KRAS 0.9690000000000001
NCK1 RAC1 0.9690000000000001
CDC42 LCK 0.9690000000000001
VAV1 HRAS 0.968
RHOA EGFR 0.968
AKT1 PIK3R2 0.968
CDC42 FYN 0.968
SHC1 RET 0.968
GRB2 MAP2K2 0.968
FRS2 GAB1 0.968
SRC PTPN11 0.968
PTPN11 MAP2K2 0.9670000000000001
ERBB2 PLCG1 0.9670000000000001
NRAS ERBB3 0.9670000000000001
SHC1 KRAS 0.9670000000000001
GRB2 FYN 0.9670000000000001
RHOA FYN 0.9670000000000001
CDC42 EGF 0.966
SOS1 PLCG1 0.966
NCK1 CBL 0.966
FRS2 SHC1 0.966
FYN KRAS 0.966
EGFR MAPK1 0.965
CDC42 RAC2 0.965
NRAS RET 0.965
HRAS SHC1 0.965
SOS1 CBL 0.965
SRC PLCG1 0.965
PIK3R1 FYN 0.965
SHC1 CAV1 0.965
CDC42 NCK2 0.965
VAV1 FYN 0.965
FYN PTPN11 0.965
SOS1 USP6NL 0.965
PIK3R1 CDC42 0.965
RHOA EGF 0.9640000000000001
MAPK3 GAB1 0.9640000000000001
CDC42 CBL 0.9640000000000001
FYN PLCG1 0.9640000000000001
CDC42 BCR 0.9640000000000001
SRC MAPK3 0.9640000000000001
SRC RAC1 0.9640000000000001
FRS2 MAPK1 0.963
GRB2 PLCG1 0.963
SRC MAPK1 0.963
SOS1 ERBB2 0.963
FGFR1 GRB2 0.963
ERBB2 PIK3R2 0.963
GRAP2 PLCG1 0.963
SRC EGFR 0.963
CDC42 ABL1 0.963
CDC42 ABI1 0.963
NCK1 FYN 0.9620000000000001
LAT2 SOS1 0.9620000000000001
ERBB3 PIK3R2 0.9620000000000001
SHC1 PTPN11 0.9620000000000001
RHOA ERBB2 0.9620000000000001
SOS1 FYN 0.9620000000000001
SRC PIK3R2 0.9620000000000001
ERBB2 ERBB3 0.9620000000000001
PIK3R1 LCK 0.9620000000000001
SRC ERBB2 0.961
CBL PIK3R2 0.961
GRB2 VAV2 0.961
SOS1 CDC42 0.961
LAT2 LCP2 0.961
SOS1 GRAP2 0.961
FRS2 SOS1 0.961
AKT1 SOS1 0.96
MAPK3 PLCG1 0.96
SOS1 ABL1 0.96
SOS1 ERBB3 0.96
LAT2 PLCG1 0.96
NCK1 SOS1 0.96
SOS1 LCK 0.96
PIK3R1 RET 0.9590000000000001
VAV1 PTPN11 0.9590000000000001
ERBB2 GAB1 0.9590000000000001
GAB1 MAPK1 0.958
LCK MAPK1 0.958
VAV1 PLCG1 0.958
GAB1 PLCG1 0.958
RHOA GRB2 0.958
NRAS MET 0.958
RAC1 BCR 0.9570000000000001
SOS1 VAV2 0.9570000000000001
SHC1 MAP2K1 0.9570000000000001
EGF CBL 0.9570000000000001
PTPN11 EGF 0.9570000000000001
VAV1 SOS1 0.9570000000000001
CDC42 EPS8 0.956
RHOA BCR 0.956
EGF PLCG1 0.956
MET PLCG1 0.956
AKT1 GAB1 0.956
ABL1 PLCG1 0.956
SOS1 LAT 0.956
SRC NRAS 0.955
GRB2 BCR 0.955
RAC1 MAP2K1 0.955
SRC RET 0.955
CDC42 MET 0.955
HRAS LCK 0.955
SOS1 MET 0.955
GRB2 LCK 0.9540000000000001
FRS2 MAPK3 0.9540000000000001
FYN EGF 0.9540000000000001
RAC1 MAPK3 0.9540000000000001
RHOA MET 0.9540000000000001
SRC MET 0.9540000000000001
LCK MAPK3 0.9540000000000001
SOS1 RET 0.9540000000000001
SRC RRAS 0.953
PTPN11 LCK 0.953
LCK PIK3R2 0.953
FYN ERBB2 0.953
PTPN11 PIK3R2 0.953
GRB2 ABL1 0.953
VAV2 LCP2 0.953
SRC MAP2K1 0.953
RHOA SOS1 0.953
FRS2 CBL 0.9520000000000001
NCK1 LAT 0.9520000000000001
SOS1 RAC2 0.9520000000000001
PIK3R1 KRAS 0.9520000000000001
CDC42 LCP2 0.9520000000000001
PIK3R1 GAB1 0.9520000000000001
PIK3R1 MET 0.9520000000000001
FGFR1 NRAS 0.9520000000000001
SOS1 RAC3 0.951
RAC1 FYN 0.95
RET GAB1 0.95
ABI1 EGFR 0.95
VAV2 FYN 0.9490000000000001
ABI1 VAV2 0.9490000000000001
RAC1 MAPK1 0.9490000000000001
SOS1 PIK3R2 0.9490000000000001
HCK PTPN11 0.948
NCK1 PLCG1 0.948
SOS1 NCK2 0.948
GRAP2 LCK 0.948
EGF GAB1 0.9470000000000001
LAT2 FYN 0.9470000000000001
PIK3R1 NCK1 0.9470000000000001
RAC1 MAP2K2 0.9470000000000001
RRAS MAPK1 0.9470000000000001
RAC1 EGFR 0.946
LCK KRAS 0.946
SOS1 RAP1A 0.946
EGFR MAPK3 0.946
ABL1 EPS8 0.946
SOS1 BCR 0.945
MET RRAS 0.945
SOS1 EGF 0.945
RAP1A MAPK3 0.945
NCK1 SRC 0.945
AKT1 FYN 0.9440000000000001
USP6NL EGFR 0.9440000000000001
RHOA LCK 0.9440000000000001
NRAS EGF 0.9440000000000001
SHC1 RHOA 0.9440000000000001
RAC1 PLCG1 0.9440000000000001
SRC MAP2K2 0.9440000000000001
PIK3R1 PLCG1 0.943
RAC1 KRAS 0.943
ABI1 RAC1 0.943
SRC RAP1A 0.943
SRC ABL1 0.943
VAV2 RAP1A 0.943
VAV1 GRAP2 0.943
MAP2K1 ERBB2 0.943
HRAS RAC1 0.943
RAC1 LCP2 0.943
VAV1 ABI1 0.943
RAP1A MAPK1 0.9420000000000001
NRAS RAC1 0.9420000000000001
ERBB3 PLCG1 0.9420000000000001
PIK3R1 RAC1 0.941
SOS1 LCP2 0.941
VAV1 PIK3R1 0.941
FYN PIK3R2 0.941
SOS1 RHOG 0.941
LCK MAP2K1 0.941
FRS2 PLCG1 0.941
LCK EGF 0.941
SHC1 LAT 0.941
SRC NCK2 0.941
FYN MAPK1 0.941
RAC1 EGF 0.941
SOS1 CAV1 0.941
PIK3R1 LCP2 0.941
RAC1 LCK 0.94
HCK HRAS 0.94
SHC1 BCR 0.94
PIK3R1 MAP2K1 0.94
SRC VAV2 0.94
EPS8 EGF 0.94
GRB2 RRAS 0.94
HCK ABL1 0.94
NCK1 HRAS 0.94
NRAS LCK 0.9390000000000001
AKT1 LCK 0.9390000000000001
AKT1 CDC42 0.9390000000000001
HRAS GAB1 0.9390000000000001
HRAS GRAP2 0.9390000000000001
BCR RAC2 0.9390000000000001
RHOA CDC42 0.9390000000000001
HCK EGF 0.938
RAP1A MAP2K1 0.938
SHC1 MAP2K2 0.938
CDC42 GRAP2 0.938
HCK SRC 0.938
RHOA KRAS 0.938
SRC RAC2 0.938
FYN GRAP2 0.938
GRB2 CAV1 0.937
FRS2 HRAS 0.937
MAP2K1 ERBB3 0.937
FYN NCK2 0.937
PIK3R1 ABI1 0.937
NRAS FYN 0.937
NCK1 LCK 0.937
PIK3R1 EGF 0.9359999999999999
FYN EGFR 0.9359999999999999
MET MAPK3 0.935
PIK3R1 BCR 0.935
ABL1 RAC1 0.935
VAV1 NCK1 0.935
RAC1 MET 0.935
NCK1 RET 0.934
RAC3 BCR 0.934
PIK3R1 NRAS 0.934
HRAS RHOA 0.934
LCK MAP2K2 0.934
CDC42 RAC3 0.934
RAC1 NCK2 0.9329999999999999
FYN RRAS 0.9329999999999999
HCK GRB2 0.9329999999999999
RAP1A MAP2K2 0.9329999999999999
FRS2 KRAS 0.9329999999999999
AKT1 EGF 0.9329999999999999
NCK1 GAB1 0.932
BCR PLCG1 0.932
ABI1 EGF 0.9309999999999999
RHOA NRAS 0.9309999999999999
PIK3R1 MAP2K2 0.9309999999999999
CDC42 PIK3R2 0.9309999999999999
RAC1 EPS8 0.93
SHC1 FGFR1 0.93
PIK3R1 GRAP2 0.929
MET MAPK1 0.929
CDC42 PLCG1 0.929
CDC42 LAT 0.929
FGFR1 GAB1 0.9279999999999999
NCK1 MET 0.9279999999999999
SHC1 NRAS 0.9279999999999999
NCK1 GRAP2 0.9279999999999999
EGFR PIK3R2 0.927
PIK3R1 EPS8 0.927
LCK EGFR 0.927
HCK LAT 0.927
RHOG BCR 0.927
HCK PIK3R1 0.927
RHOA RAP1A 0.927
RAP1A MET 0.927
USP6NL EGF 0.927
NCK1 EGFR 0.9259999999999999
HCK VAV2 0.9259999999999999
VAV2 LCK 0.9259999999999999
SHC1 ABL1 0.9259999999999999
RHOA RAC2 0.925
RAC1 GRAP2 0.924
SRC RAC3 0.924
RHOA PIK3R2 0.9229999999999999
PIK3R1 RHOA 0.9229999999999999
RHOA RAC1 0.9229999999999999
VAV2 GRAP2 0.9229999999999999
LCK RRAS 0.922
PIK3R1 RAC2 0.922
FGFR1 BCR 0.922
MAP2K1 GAB1 0.922
HCK PIK3R2 0.9209999999999999
LCK NCK2 0.9209999999999999
HRAS RAP1A 0.9209999999999999
RAP1A NRAS 0.9209999999999999
RAP1A KRAS 0.92
FRS2 PIK3R1 0.92
RHOA RAC3 0.92
ABI1 MAPK3 0.92
RHOG RAC2 0.919
PLCG1 PIK3R2 0.919
ABI1 MAPK1 0.917
RAP1A PTPN11 0.917
FRS2 NRAS 0.917
MET NCK2 0.917
RAC1 RRAS 0.9159999999999999
GAB1 PIK3R2 0.9159999999999999
MET ERBB3 0.915
VAV2 PLCG1 0.914
RAC1 GAB1 0.914
RAP1A GAB1 0.914
ABL1 FYN 0.9129999999999999
HCK GAB1 0.9129999999999999
RAC2 PIK3R2 0.9129999999999999
GRAP2 PIK3R2 0.912
RAC3 PIK3R2 0.912
PIK3R1 RAP1A 0.9109999999999999
RHOG PIK3R2 0.9109999999999999
RAC1 PIK3R2 0.9109999999999999
ERBB2 CBL 0.91
RET PIK3R2 0.91
VAV2 PIK3R2 0.909
SHC1 RAP1A 0.909
PIK3R1 RHOG 0.9079999999999999
AKT1 MAPK3 0.907
FYN LCK 0.907
GAB1 NCK2 0.907
RAP1A CBL 0.9059999999999999
RAC1 RAC2 0.9059999999999999
FRS2 PIK3R2 0.9059999999999999
CDC42 RAC1 0.9059999999999999
SRC LCK 0.9059999999999999
RHOA RHOG 0.9059999999999999
ABL1 LCK 0.9059999999999999
CDC42 RHOG 0.9059999999999999
RAP1A RET 0.9059999999999999
HCK LCK 0.9059999999999999
HCK FYN 0.905
AKT1 MAPK1 0.905
VAV1 VAV2 0.905
RAC1 RHOG 0.905
RHOG RAC3 0.904
FRS2 RAP1A 0.904
VAV1 PIK3R2 0.903
PIK3R1 VAV2 0.903
VAV2 BCR 0.903
PIK3R2 LCP2 0.902
AKT1 HRAS 0.9009999999999999
PIK3R1 LAT2 0.9
FYN RAC2 0.9
LAT2 PIK3R2 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 6464 (SHC1) 5781 (PTPN11) 1956 (EGFR) 3265 (HRAS) 2885 (GRB2) 6654 (SOS1) 6714 (SRC) 9402 (GRAP2) 7409 (VAV1) 10006 (ABI1) 10818 (FRS2) 2064 (ERBB2) 2059 (EPS8) 4893 (NRAS) 2534 (FYN) 27040 (LAT) 5295 (PIK3R1) 857 (CAV1) 2260 (FGFR1) 207 (AKT1) 5595 (MAPK3) 5604 (MAP2K1) 5605 (MAP2K2) 2065 (ERBB3) 3932 (LCK) 998 (CDC42) 4690 (NCK1) 7410 (VAV2) 4233 (MET) 3845 (KRAS) 5979 (RET) 5881 (RAC3) 387 (RHOA) 5879 (RAC1) 25 (ABL1) 3055 (HCK) 867 (CBL) 1950 (EGF) 7462 (LAT2) 5335 (PLCG1) 2549 (GAB1) 6237 (RRAS) 5906 (RAP1A) 9712 (USP6NL) 613 (BCR) 391 (RHOG) 5880 (RAC2) 5296 (PIK3R2) 3937 (LCP2) 5594 (MAPK1) 8440 (NCK2)
6464 (SHC1) 1.00 0.58 0.55 0.54 0.77 0.67 0.64 0.60 0.66 0.62 0.72 0.61 0.64 0.59 0.66 0.71 0.73 0.64 0.52 0.56 0.53 0.52 0.51 0.56 0.64 0.56 0.69 0.72 0.56 0.59 0.55 0.59 0.58 0.57 0.57 0.65 0.65 0.63 0.60 0.62 0.54 0.54 0.62 0.30 0.51 0.57 0.53 0.63 1.00 0.51 0.65
5781 (PTPN11) 0.58 1.00 0.55 0.43 0.74 0.38 0.72 0.53 0.59 0.51 0.60 0.60 0.51 0.46 0.60 0.57 0.68 0.56 0.56 0.55 0.58 0.57 0.53 0.55 0.80 0.57 0.59 0.48 0.56 0.46 0.45 0.51 0.51 0.59 0.62 0.62 0.51 0.56 0.47 0.57 0.73 0.44 0.42 0.22 0.53 0.49 0.42 0.66 1.00 0.57 0.60
1956 (EGFR) 0.55 0.55 1.00 0.44 0.68 0.56 0.73 0.47 0.63 0.56 0.64 0.85 0.53 0.50 0.73 0.54 0.64 0.58 0.77 0.69 0.67 0.65 0.62 0.84 0.71 0.60 0.54 0.54 0.84 0.50 0.76 0.47 0.46 0.62 0.65 0.64 0.52 0.74 0.48 0.45 0.59 0.47 0.53 0.29 0.64 0.45 0.44 0.65 1.00 0.67 0.48
3265 (HRAS) 0.54 0.43 0.44 1.00 0.53 0.41 0.57 0.55 0.43 0.61 0.41 0.53 0.51 0.55 0.50 0.52 0.50 0.57 0.39 0.54 0.48 0.48 0.44 0.45 0.56 0.76 0.57 0.48 0.42 0.55 0.37 0.91 0.90 0.82 0.57 0.49 0.50 0.44 0.57 0.48 0.45 0.92 0.47 0.25 0.42 0.92 0.96 0.44 1.00 0.45 0.56
2885 (GRB2) 0.77 0.74 0.68 0.53 1.00 0.65 0.77 0.63 0.75 0.64 0.79 0.72 0.66 0.58 0.76 0.74 0.74 0.64 0.69 0.64 0.66 0.63 0.61 0.68 0.74 0.64 0.66 0.69 0.71 0.58 0.62 0.59 0.59 0.64 0.71 0.70 0.64 0.73 0.59 0.62 0.77 0.54 0.61 0.29 0.62 0.58 0.53 0.72 1.00 0.65 0.67
6654 (SOS1) 0.67 0.38 0.56 0.41 0.65 1.00 0.53 0.48 0.74 0.56 0.65 0.64 0.69 0.49 0.63 0.79 0.53 0.60 0.50 0.47 0.43 0.46 0.45 0.59 0.52 0.45 0.56 0.86 0.58 0.49 0.57 0.45 0.44 0.46 0.46 0.45 0.46 0.63 0.50 0.41 0.40 0.41 0.68 0.54 0.57 0.41 0.39 0.56 1.00 0.41 0.51
6714 (SRC) 0.64 0.72 0.73 0.57 0.77 0.53 1.00 0.63 0.67 0.64 0.69 0.76 0.61 0.59 0.81 0.63 0.70 0.66 0.70 0.74 0.77 0.78 0.74 0.70 0.85 0.71 0.67 0.57 0.74 0.59 0.68 0.59 0.58 0.73 0.79 0.81 0.67 0.74 0.63 0.58 0.76 0.56 0.56 0.30 0.76 0.58 0.56 0.68 1.00 0.77 0.64
9402 (GRAP2) 0.60 0.53 0.47 0.55 0.63 0.48 0.63 1.00 0.50 0.76 0.48 0.57 0.76 0.79 0.55 0.80 0.56 0.62 0.39 0.47 0.56 0.51 0.51 0.48 0.58 0.54 0.73 0.60 0.47 0.79 0.41 0.61 0.59 0.58 0.51 0.60 0.57 0.49 0.81 0.55 0.71 0.57 0.59 0.35 0.50 0.57 0.57 0.50 1.00 0.51 0.84
7409 (VAV1) 0.66 0.59 0.63 0.43 0.75 0.74 0.67 0.50 1.00 0.56 0.70 0.71 0.64 0.50 0.70 0.66 0.66 0.58 0.63 0.58 0.59 0.59 0.56 0.65 0.68 0.52 0.56 0.84 0.69 0.50 0.58 0.47 0.45 0.54 0.59 0.65 0.60 0.70 0.51 0.43 0.65 0.43 0.59 0.29 0.56 0.43 0.41 0.67 1.00 0.58 0.60
10006 (ABI1) 0.62 0.51 0.56 0.61 0.64 0.56 0.64 0.76 0.56 1.00 0.53 0.59 0.68 0.89 0.59 0.68 0.58 0.64 0.45 0.52 0.61 0.56 0.57 0.53 0.60 0.58 0.71 0.65 0.52 0.89 0.49 0.65 0.65 0.61 0.57 0.65 0.71 0.54 0.79 0.61 0.62 0.72 0.73 0.35 0.58 0.63 0.63 0.55 1.00 0.57 0.73
10818 (FRS2) 0.72 0.60 0.64 0.41 0.79 0.65 0.69 0.48 0.70 0.53 1.00 0.70 0.56 0.47 0.71 0.61 0.76 0.59 0.65 0.59 0.59 0.61 0.58 0.66 0.66 0.53 0.58 0.60 0.67 0.47 0.57 0.46 0.45 0.55 0.57 0.59 0.52 0.70 0.48 0.50 0.72 0.41 0.54 0.31 0.60 0.43 0.39 0.71 1.00 0.58 0.51
2064 (ERBB2) 0.61 0.60 0.85 0.53 0.72 0.64 0.76 0.57 0.71 0.59 0.70 1.00 0.60 0.57 0.78 0.64 0.70 0.61 0.83 0.68 0.72 0.71 0.66 0.89 0.77 0.63 0.59 0.63 0.92 0.57 0.83 0.54 0.53 0.64 0.66 0.73 0.57 0.81 0.57 0.52 0.68 0.52 0.60 0.29 0.69 0.52 0.52 0.71 1.00 0.72 0.57
2059 (EPS8) 0.64 0.51 0.53 0.51 0.66 0.69 0.61 0.76 0.64 0.68 0.56 0.60 1.00 0.64 0.59 0.80 0.55 0.66 0.46 0.48 0.53 0.50 0.49 0.54 0.56 0.52 0.68 0.74 0.53 0.64 0.51 0.56 0.55 0.55 0.52 0.55 0.54 0.56 0.65 0.52 0.62 0.53 0.63 0.40 0.49 0.53 0.52 0.49 1.00 0.49 0.72
4893 (NRAS) 0.59 0.46 0.50 0.55 0.58 0.49 0.59 0.79 0.50 0.89 0.47 0.57 0.64 1.00 0.55 0.66 0.55 0.62 0.40 0.48 0.57 0.52 0.51 0.49 0.58 0.54 0.65 0.61 0.47 1.00 0.42 0.61 0.59 0.58 0.52 0.61 0.57 0.49 0.82 0.56 0.56 0.72 0.73 0.35 0.51 0.58 0.57 0.50 1.00 0.52 0.70
2534 (FYN) 0.66 0.60 0.73 0.50 0.76 0.63 0.81 0.55 0.70 0.59 0.71 0.78 0.59 0.55 1.00 0.63 0.66 0.65 0.72 0.69 0.70 0.69 0.66 0.73 0.78 0.64 0.60 0.62 0.78 0.55 0.69 0.53 0.52 0.65 0.69 0.77 0.59 0.76 0.55 0.51 0.67 0.50 0.58 0.29 0.69 0.51 0.50 0.64 1.00 0.70 0.56
27040 (LAT) 0.71 0.57 0.54 0.52 0.74 0.79 0.63 0.80 0.66 0.68 0.61 0.64 0.80 0.66 0.63 1.00 0.56 0.66 0.49 0.49 0.53 0.50 0.50 0.57 0.60 0.58 0.72 0.78 0.57 0.66 0.55 0.65 0.64 0.61 0.54 0.56 0.57 0.60 0.68 0.61 0.63 0.53 0.71 0.36 0.50 0.63 0.52 0.54 1.00 0.49 0.74
5295 (PIK3R1) 0.73 0.68 0.64 0.50 0.74 0.53 0.70 0.56 0.66 0.58 0.76 0.70 0.55 0.55 0.66 0.56 1.00 0.62 0.61 0.62 0.63 0.64 0.62 0.62 0.74 0.57 0.64 0.59 0.65 0.55 0.54 0.53 0.52 0.59 0.61 0.68 0.57 0.63 0.56 0.56 0.70 0.51 0.53 0.31 0.62 0.52 0.50 0.83 1.00 0.63 0.60
857 (CAV1) 0.64 0.56 0.58 0.57 0.64 0.60 0.66 0.62 0.58 0.64 0.59 0.61 0.66 0.62 0.65 0.66 0.62 1.00 0.51 0.60 0.60 0.58 0.58 0.58 0.67 0.63 0.68 0.61 0.56 0.62 0.53 0.63 0.62 0.65 0.58 0.61 0.60 0.58 0.63 0.61 0.57 0.58 0.59 0.42 0.60 0.62 0.58 0.60 1.00 0.58 0.65
2260 (FGFR1) 0.52 0.56 0.77 0.39 0.69 0.50 0.70 0.39 0.63 0.45 0.65 0.83 0.46 0.40 0.72 0.49 0.61 0.51 1.00 0.66 0.63 0.63 0.58 0.84 0.69 0.57 0.47 0.48 0.86 0.40 0.78 0.40 0.39 0.56 0.61 0.64 0.45 0.75 0.40 0.37 0.63 0.38 0.45 0.21 0.61 0.38 0.36 0.60 1.00 0.63 0.43
207 (AKT1) 0.56 0.55 0.69 0.54 0.64 0.47 0.74 0.47 0.58 0.52 0.59 0.68 0.48 0.48 0.69 0.49 0.62 0.60 0.66 1.00 0.77 0.75 0.72 0.67 0.72 0.72 0.54 0.48 0.67 0.48 0.59 0.54 0.53 0.73 0.72 0.68 0.53 0.63 0.48 0.45 0.60 0.51 0.46 0.28 0.71 0.52 0.51 0.61 1.00 0.77 0.49
5595 (MAPK3) 0.53 0.58 0.67 0.48 0.66 0.43 0.77 0.56 0.59 0.61 0.59 0.72 0.53 0.57 0.70 0.53 0.63 0.60 0.63 0.77 1.00 0.79 0.77 0.65 0.76 0.71 0.58 0.50 0.71 0.57 0.60 0.52 0.51 0.73 0.69 0.77 0.59 0.64 0.58 0.49 0.69 0.49 0.49 0.28 0.78 0.49 0.48 0.63 1.00 0.99 0.57
5604 (MAP2K1) 0.52 0.57 0.65 0.48 0.63 0.46 0.78 0.51 0.59 0.56 0.61 0.71 0.50 0.52 0.69 0.50 0.64 0.58 0.63 0.75 0.79 1.00 0.95 0.70 0.73 0.68 0.58 0.48 0.69 0.52 0.64 0.49 0.48 0.70 0.69 0.77 0.55 0.71 0.53 0.46 0.66 0.46 0.47 0.29 0.77 0.46 0.45 0.64 1.00 0.80 0.53
5605 (MAP2K2) 0.51 0.53 0.62 0.44 0.61 0.45 0.74 0.51 0.56 0.57 0.58 0.66 0.49 0.51 0.66 0.50 0.62 0.58 0.58 0.72 0.77 0.95 1.00 0.67 0.68 0.65 0.59 0.47 0.64 0.51 0.59 0.48 0.47 0.67 0.65 0.73 0.53 0.67 0.53 0.44 0.62 0.45 0.46 0.30 0.72 0.45 0.43 0.61 1.00 0.78 0.53
2065 (ERBB3) 0.56 0.55 0.84 0.45 0.68 0.59 0.70 0.48 0.65 0.53 0.66 0.89 0.54 0.49 0.73 0.57 0.62 0.58 0.84 0.67 0.65 0.70 0.67 1.00 0.69 0.58 0.55 0.57 0.88 0.49 0.81 0.47 0.46 0.58 0.62 0.65 0.50 0.83 0.49 0.45 0.61 0.45 0.53 0.28 0.64 0.45 0.44 0.64 1.00 0.65 0.50
3932 (LCK) 0.64 0.80 0.71 0.56 0.74 0.52 0.85 0.58 0.68 0.60 0.66 0.77 0.56 0.58 0.78 0.60 0.74 0.67 0.69 0.72 0.76 0.73 0.68 0.69 1.00 0.70 0.62 0.59 0.76 0.58 0.65 0.59 0.59 0.71 0.78 0.82 0.62 0.71 0.62 0.61 0.70 0.55 0.55 0.29 0.74 0.58 0.55 0.72 1.00 0.76 0.62
998 (CDC42) 0.56 0.57 0.60 0.76 0.64 0.45 0.71 0.54 0.52 0.58 0.53 0.63 0.52 0.54 0.64 0.58 0.57 0.63 0.57 0.72 0.71 0.68 0.65 0.58 0.70 1.00 0.58 0.50 0.60 0.54 0.53 0.79 0.78 0.88 0.69 0.65 0.67 0.56 0.56 0.55 0.58 0.72 0.50 0.27 0.61 0.79 0.74 0.56 1.00 0.72 0.55
4690 (NCK1) 0.69 0.59 0.54 0.57 0.66 0.56 0.67 0.73 0.56 0.71 0.58 0.59 0.68 0.65 0.60 0.72 0.64 0.68 0.47 0.54 0.58 0.58 0.59 0.55 0.62 0.58 1.00 0.61 0.52 0.65 0.51 0.62 0.61 0.60 0.56 0.63 0.67 0.58 0.66 0.60 0.65 0.58 0.59 0.33 0.57 0.61 0.58 0.62 1.00 0.55 0.80
7410 (VAV2) 0.72 0.48 0.54 0.48 0.69 0.86 0.57 0.60 0.84 0.65 0.60 0.63 0.74 0.61 0.62 0.78 0.59 0.61 0.48 0.48 0.50 0.48 0.47 0.57 0.59 0.50 0.61 1.00 0.57 0.61 0.55 0.53 0.51 0.52 0.52 0.61 0.52 0.60 0.62 0.49 0.48 0.49 0.69 0.35 0.47 0.49 0.48 0.56 1.00 0.46 0.69
4233 (MET) 0.56 0.56 0.84 0.42 0.71 0.58 0.74 0.47 0.69 0.52 0.67 0.92 0.53 0.47 0.78 0.57 0.65 0.56 0.86 0.67 0.71 0.69 0.64 0.88 0.76 0.60 0.52 0.57 1.00 0.47 0.88 0.45 0.44 0.61 0.64 0.72 0.50 0.84 0.48 0.42 0.65 0.42 0.52 0.25 0.68 0.42 0.41 0.65 1.00 0.71 0.49
3845 (KRAS) 0.59 0.46 0.50 0.55 0.58 0.49 0.59 0.79 0.50 0.89 0.47 0.57 0.64 1.00 0.55 0.66 0.55 0.62 0.40 0.48 0.57 0.52 0.51 0.49 0.58 0.54 0.65 0.61 0.47 1.00 0.42 0.61 0.59 0.58 0.52 0.61 0.57 0.49 0.82 0.56 0.56 0.72 0.73 0.35 0.51 0.58 0.57 0.50 1.00 0.52 0.70
5979 (RET) 0.55 0.45 0.76 0.37 0.62 0.57 0.68 0.41 0.58 0.49 0.57 0.83 0.51 0.42 0.69 0.55 0.54 0.53 0.78 0.59 0.60 0.64 0.59 0.81 0.65 0.53 0.51 0.55 0.88 0.42 1.00 0.40 0.39 0.54 0.64 0.66 0.46 0.78 0.43 0.37 0.50 0.37 0.49 0.22 0.60 0.37 0.34 0.50 1.00 0.61 0.46
5881 (RAC3) 0.59 0.51 0.47 0.91 0.59 0.45 0.59 0.61 0.47 0.65 0.46 0.54 0.56 0.61 0.53 0.65 0.53 0.63 0.40 0.54 0.52 0.49 0.48 0.47 0.59 0.79 0.62 0.53 0.45 0.61 0.40 1.00 0.95 0.86 0.59 0.54 0.56 0.47 0.63 0.60 0.50 0.86 0.52 0.29 0.47 0.98 0.93 0.50 1.00 0.48 0.60
387 (RHOA) 0.58 0.51 0.46 0.90 0.59 0.44 0.58 0.59 0.45 0.65 0.45 0.53 0.55 0.59 0.52 0.64 0.52 0.62 0.39 0.53 0.51 0.48 0.47 0.46 0.59 0.78 0.61 0.51 0.44 0.59 0.39 0.95 1.00 0.85 0.58 0.52 0.55 0.46 0.61 0.59 0.48 0.85 0.51 0.28 0.45 0.97 0.91 0.49 1.00 0.47 0.59
5879 (RAC1) 0.57 0.59 0.62 0.82 0.64 0.46 0.73 0.58 0.54 0.61 0.55 0.64 0.55 0.58 0.65 0.61 0.59 0.65 0.56 0.73 0.73 0.70 0.67 0.58 0.71 0.88 0.60 0.52 0.61 0.58 0.54 0.86 0.85 1.00 0.70 0.67 0.58 0.58 0.59 0.58 0.61 0.77 0.52 0.32 0.63 0.86 0.81 0.58 1.00 0.74 0.58
25 (ABL1) 0.57 0.62 0.65 0.57 0.71 0.46 0.79 0.51 0.59 0.57 0.57 0.66 0.52 0.52 0.69 0.54 0.61 0.58 0.61 0.72 0.69 0.69 0.65 0.62 0.78 0.69 0.56 0.52 0.64 0.52 0.64 0.59 0.58 0.70 1.00 0.73 0.61 0.62 0.55 0.52 0.60 0.54 0.49 0.24 0.68 0.58 0.54 0.61 1.00 0.69 0.55
3055 (HCK) 0.65 0.62 0.64 0.49 0.70 0.45 0.81 0.60 0.65 0.65 0.59 0.73 0.55 0.61 0.77 0.56 0.68 0.61 0.64 0.68 0.77 0.77 0.73 0.65 0.82 0.65 0.63 0.61 0.72 0.61 0.66 0.54 0.52 0.67 0.73 1.00 0.59 0.70 0.62 0.51 0.68 0.51 0.52 0.27 0.79 0.51 0.49 0.66 1.00 0.76 0.68
867 (CBL) 0.65 0.51 0.52 0.50 0.64 0.46 0.67 0.57 0.60 0.71 0.52 0.57 0.54 0.57 0.59 0.57 0.57 0.60 0.45 0.53 0.59 0.55 0.53 0.50 0.62 0.67 0.67 0.52 0.50 0.57 0.46 0.56 0.55 0.58 0.61 0.59 1.00 0.51 0.59 0.53 0.54 0.51 0.51 0.27 0.55 0.54 0.50 0.57 1.00 0.57 0.58
1950 (EGF) 0.63 0.56 0.74 0.44 0.73 0.63 0.74 0.49 0.70 0.54 0.70 0.81 0.56 0.49 0.76 0.60 0.63 0.58 0.75 0.63 0.64 0.71 0.67 0.83 0.71 0.56 0.58 0.60 0.84 0.49 0.78 0.47 0.46 0.58 0.62 0.70 0.51 1.00 0.50 0.44 0.64 0.44 0.55 0.28 0.65 0.44 0.43 0.62 1.00 0.65 0.51
7462 (LAT2) 0.60 0.47 0.48 0.57 0.59 0.50 0.63 0.81 0.51 0.79 0.48 0.57 0.65 0.82 0.55 0.68 0.56 0.63 0.40 0.48 0.58 0.53 0.53 0.49 0.62 0.56 0.66 0.62 0.48 0.82 0.43 0.63 0.61 0.59 0.55 0.62 0.59 0.50 1.00 0.57 0.58 0.60 0.61 0.36 0.52 0.60 0.59 0.51 1.00 0.53 0.72
5335 (PLCG1) 0.62 0.57 0.45 0.48 0.62 0.41 0.58 0.55 0.43 0.61 0.50 0.52 0.52 0.56 0.51 0.61 0.56 0.61 0.37 0.45 0.49 0.46 0.44 0.45 0.61 0.55 0.60 0.49 0.42 0.56 0.37 0.60 0.59 0.58 0.52 0.51 0.53 0.44 0.57 1.00 0.46 0.49 0.48 0.26 0.43 0.58 0.47 0.47 1.00 0.46 0.57
2549 (GAB1) 0.54 0.73 0.59 0.45 0.77 0.40 0.76 0.71 0.65 0.62 0.72 0.68 0.62 0.56 0.67 0.63 0.70 0.57 0.63 0.60 0.69 0.66 0.62 0.61 0.70 0.58 0.65 0.48 0.65 0.56 0.50 0.50 0.48 0.61 0.60 0.68 0.54 0.64 0.58 0.46 1.00 0.46 0.47 0.25 0.64 0.46 0.44 0.71 1.00 0.68 0.68
6237 (RRAS) 0.54 0.44 0.47 0.92 0.54 0.41 0.56 0.57 0.43 0.72 0.41 0.52 0.53 0.72 0.50 0.53 0.51 0.58 0.38 0.51 0.49 0.46 0.45 0.45 0.55 0.72 0.58 0.49 0.42 0.72 0.37 0.86 0.85 0.77 0.54 0.51 0.51 0.44 0.60 0.49 0.46 1.00 0.59 0.26 0.43 0.87 0.91 0.45 1.00 0.46 0.58
5906 (RAP1A) 0.62 0.42 0.53 0.47 0.61 0.68 0.56 0.59 0.59 0.73 0.54 0.60 0.63 0.73 0.58 0.71 0.53 0.59 0.45 0.46 0.49 0.47 0.46 0.53 0.55 0.50 0.59 0.69 0.52 0.73 0.49 0.52 0.51 0.52 0.49 0.52 0.51 0.55 0.61 0.48 0.47 0.59 1.00 0.31 0.45 0.48 0.47 0.47 1.00 0.46 0.59
9712 (USP6NL) 0.30 0.22 0.29 0.25 0.29 0.54 0.30 0.35 0.29 0.35 0.31 0.29 0.40 0.35 0.29 0.36 0.31 0.42 0.21 0.28 0.28 0.29 0.30 0.28 0.29 0.27 0.33 0.35 0.25 0.35 0.22 0.29 0.28 0.32 0.24 0.27 0.27 0.28 0.36 0.26 0.25 0.26 0.31 1.00 0.53 0.28 0.25 0.43 0.49 0.26 0.32
613 (BCR) 0.51 0.53 0.64 0.42 0.62 0.57 0.76 0.50 0.56 0.58 0.60 0.69 0.49 0.51 0.69 0.50 0.62 0.60 0.61 0.71 0.78 0.77 0.72 0.64 0.74 0.61 0.57 0.47 0.68 0.51 0.60 0.47 0.45 0.63 0.68 0.79 0.55 0.65 0.52 0.43 0.64 0.43 0.45 0.53 1.00 0.42 0.40 0.71 1.00 0.77 0.53
391 (RHOG) 0.57 0.49 0.45 0.92 0.58 0.41 0.58 0.57 0.43 0.63 0.43 0.52 0.53 0.58 0.51 0.63 0.52 0.62 0.38 0.52 0.49 0.46 0.45 0.45 0.58 0.79 0.61 0.49 0.42 0.58 0.37 0.98 0.97 0.86 0.58 0.51 0.54 0.44 0.60 0.58 0.46 0.87 0.48 0.28 0.42 1.00 0.94 0.47 1.00 0.45 0.58
5880 (RAC2) 0.53 0.42 0.44 0.96 0.53 0.39 0.56 0.57 0.41 0.63 0.39 0.52 0.52 0.57 0.50 0.52 0.50 0.58 0.36 0.51 0.48 0.45 0.43 0.44 0.55 0.74 0.58 0.48 0.41 0.57 0.34 0.93 0.91 0.81 0.54 0.49 0.50 0.43 0.59 0.47 0.44 0.91 0.47 0.25 0.40 0.94 1.00 0.43 1.00 0.44 0.58
5296 (PIK3R2) 0.63 0.66 0.65 0.44 0.72 0.56 0.68 0.50 0.67 0.55 0.71 0.71 0.49 0.50 0.64 0.54 0.83 0.60 0.60 0.61 0.63 0.64 0.61 0.64 0.72 0.56 0.62 0.56 0.65 0.50 0.50 0.50 0.49 0.58 0.61 0.66 0.57 0.62 0.51 0.47 0.71 0.45 0.47 0.43 0.71 0.47 0.43 1.00 1.00 0.62 0.58
3937 (LCP2) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.49 1.00 1.00 1.00 1.00 1.00 1.00 1.00
5594 (MAPK1) 0.51 0.57 0.67 0.45 0.65 0.41 0.77 0.51 0.58 0.57 0.58 0.72 0.49 0.52 0.70 0.49 0.63 0.58 0.63 0.77 0.99 0.80 0.78 0.65 0.76 0.72 0.55 0.46 0.71 0.52 0.61 0.48 0.47 0.74 0.69 0.76 0.57 0.65 0.53 0.46 0.68 0.46 0.46 0.26 0.77 0.45 0.44 0.62 1.00 1.00 0.53
8440 (NCK2) 0.65 0.60 0.48 0.56 0.67 0.51 0.64 0.84 0.60 0.73 0.51 0.57 0.72 0.70 0.56 0.74 0.60 0.65 0.43 0.49 0.57 0.53 0.53 0.50 0.62 0.55 0.80 0.69 0.49 0.70 0.46 0.60 0.59 0.58 0.55 0.68 0.58 0.51 0.72 0.57 0.68 0.58 0.59 0.32 0.53 0.58 0.58 0.58 1.00 0.53 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
SOS1 Human Blood - 3250 m 4 day upregulated 2.52 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
SOS1 Human Blood - 3250 m 4 day upregulated 2.52 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
SOS1 Human Blood - 3250 m 4 day upregulated 2.52 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT046240 hsa-miR-23b-3p Homo sapiens SOS1 6654 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT088625 hsa-miR-4325 Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT236646 hsa-miR-4789-5p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT236655 hsa-miR-5011-5p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT437439 hsa-miR-124-3p Homo sapiens SOS1 6654 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 23817964
MIRT494978 hsa-miR-5571-5p Homo sapiens SOS1 6654 Homo sapiens PAR-CLIP Functional MTI (Weak) 23708386
MIRT494976 hsa-miR-6715a-3p Homo sapiens SOS1 6654 Homo sapiens PAR-CLIP Functional MTI (Weak) 23708386
MIRT494975 hsa-miR-3157-5p Homo sapiens SOS1 6654 Homo sapiens PAR-CLIP Functional MTI (Weak) 23708386
MIRT494977 hsa-miR-4691-3p Homo sapiens SOS1 6654 Homo sapiens PAR-CLIP Functional MTI (Weak) 23708386
MIRT699006 hsa-miR-4801 Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699014 hsa-miR-3681-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699012 hsa-miR-433-5p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699013 hsa-miR-216a-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699004 hsa-miR-4643 Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699005 hsa-miR-4789-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699016 hsa-miR-27b-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699002 hsa-miR-5089-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699015 hsa-miR-128-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699008 hsa-miR-548an Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699017 hsa-miR-27a-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699010 hsa-miR-196b-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699009 hsa-miR-1178-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699003 hsa-miR-466 Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699007 hsa-miR-4731-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT699011 hsa-miR-3613-3p Homo sapiens SOS1 6654 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT731133 hsa-miR-146a-5p Homo sapiens SOS1 6654 Homo sapiens Western blot//Luciferase reporter assay Functional MTI 25469565
Gene Ontology
ID GO ID GO Term GO Type
6654 GO:0003209 cardiac atrium morphogenesis GOTERM_BP_DIRECT
6654 GO:0000165 MAPK cascade GOTERM_BP_DIRECT
6654 GO:0001782 B cell homeostasis GOTERM_BP_DIRECT
6654 GO:0001942 hair follicle development GOTERM_BP_DIRECT
6654 GO:0007173 epidermal growth factor receptor signaling pathway GOTERM_BP_DIRECT
6654 GO:0003344 pericardium morphogenesis GOTERM_BP_DIRECT
6654 GO:0007165 signal transduction GOTERM_BP_DIRECT
6654 GO:0007265 Ras protein signal transduction GOTERM_BP_DIRECT
6654 GO:0017124 nucleoside-triphosphatase activity GOTERM_MF_DIRECT
6654 GO:1904693 midbrain morphogenesis GOTERM_BP_DIRECT
6654 GO:0035264 multicellular organism growth GOTERM_BP_DIRECT
6654 GO:2000973 regulation of pro-B cell differentiation GOTERM_BP_DIRECT
6654 GO:0005089 Rho guanyl-nucleotide exchange factor activity GOTERM_MF_DIRECT
6654 GO:0014069 postsynaptic density GOTERM_CC_DIRECT
6654 GO:0008286 insulin receptor signaling pathway GOTERM_BP_DIRECT
6654 GO:0038128 ERBB2 signaling pathway GOTERM_BP_DIRECT
6654 GO:0043547 positive regulation of GTPase activity GOTERM_BP_DIRECT
6654 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GOTERM_BP_DIRECT
6654 GO:0051056 regulation of small GTPase mediated signal transduction GOTERM_BP_DIRECT
6654 GO:0061029 eyelid development in camera-type eye GOTERM_BP_DIRECT
6654 GO:0005829 cytosol GOTERM_CC_DIRECT
6654 GO:0060021 palate development GOTERM_BP_DIRECT
6654 GO:0046982 protein heterodimerization activity GOTERM_MF_DIRECT
6654 GO:0061384 heart trabecula morphogenesis GOTERM_BP_DIRECT
6654 GO:0005096 GTPase activator activity GOTERM_MF_DIRECT
6654 GO:0007264 small GTPase mediated signal transduction GOTERM_BP_DIRECT
6654 GO:0035023 regulation of Rho protein signal transduction GOTERM_BP_DIRECT
6654 GO:0050900 leukocyte migration GOTERM_BP_DIRECT
6654 GO:0043025 neuronal cell body GOTERM_CC_DIRECT
6654 GO:0005515 protein binding GOTERM_MF_DIRECT
6654 GO:0007296 vitellogenesis GOTERM_BP_DIRECT
6654 GO:0048514 blood vessel morphogenesis GOTERM_BP_DIRECT
6654 GO:0005088 guanyl-nucleotide exchange factor activity GOTERM_MF_DIRECT
6654 GO:0038095 Fc-epsilon receptor signaling pathway GOTERM_BP_DIRECT
6654 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
6654 GO:0003677 DNA binding GOTERM_MF_DIRECT
6654 GO:0005886 plasma membrane GOTERM_CC_DIRECT
6654 GO:0048011 neurotrophin TRK receptor signaling pathway GOTERM_BP_DIRECT
6654 GO:0007411 axon guidance GOTERM_BP_DIRECT
6654 GO:0042129 regulation of T cell proliferation GOTERM_BP_DIRECT
6654 GO:0051057 positive regulation of small GTPase mediated signal transduction GOTERM_BP_DIRECT
6654 GO:0033081 regulation of T cell differentiation in thymus GOTERM_BP_DIRECT
6654 GO:0005085 guanyl-nucleotide exchange factor activity GOTERM_MF_DIRECT
6654 GO:0005622 intracellular GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
6654 hsa04012 ErbB signaling pathway
6654 hsa04014 Ras signaling pathway
6654 hsa04010 MAPK signaling pathway
6654 hsa04062 Chemokine signaling pathway
6654 hsa04068 FoxO signaling pathway
6654 hsa04151 PI3K-Akt signaling pathway
6654 hsa04320 Dorso-ventral axis formation
6654 hsa04540 Gap junction
6654 hsa04510 Focal adhesion
6654 hsa04650 Natural killer cell mediated cytotoxicity
6654 hsa04630 Jak-STAT signaling pathway
6654 hsa04664 Fc epsilon RI signaling pathway
6654 hsa04660 T cell receptor signaling pathway
6654 hsa04662 B cell receptor signaling pathway
6654 hsa04722 Neurotrophin signaling pathway
6654 hsa04810 Regulation of actin cytoskeleton
6654 hsa04910 Insulin signaling pathway
6654 hsa04917 Prolactin signaling pathway
6654 hsa04912 GnRH signaling pathway
6654 hsa04915 Estrogen signaling pathway
6654 hsa05034 Alcoholism
6654 hsa05200 Pathways in cancer
6654 hsa05160 Hepatitis C
6654 hsa05211 Renal cell carcinoma
6654 hsa05213 Endometrial cancer
6654 hsa05205 Proteoglycans in cancer
6654 hsa05214 Glioma
6654 hsa05206 MicroRNAs in cancer
6654 hsa05215 Prostate cancer
6654 hsa05231 Choline metabolism in cancer
6654 hsa05221 Acute myeloid leukemia
6654 hsa05223 Non-small cell lung cancer
6654 hsa05220 Chronic myeloid leukemia
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
SOS1 6654 Noonan Syndrome 4 C1853120 Disease or Syndrome 0.9 0.536 0.655 disease
SOS1 6654 Adenocarcinoma of lung (disorder) C0152013 Neoplastic Process 0.4 0.536 0.655 disease
SOS1 6654 Female Pseudo-Turner Syndrome C1527404 Congenital Abnormality 0.3 0.536 0.655 disease
SOS1 6654 Turner Syndrome, Male C0041409 Disease or Syndrome 0.4 0.536 0.655 disease
SOS1 6654 Hereditary gingival fibromatosis C0399440 Disease or Syndrome 0.67 0.536 0.655 disease
SOS1 6654 Noonan Syndrome C0028326 Disease or Syndrome 0.7 0.536 0.655 disease
SOS1 6654 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.536 0.655 group
SOS1 6654 Charcot-Marie-Tooth Disease C0007959 Disease or Syndrome 0.3 0.536 0.655 disease
SOS1 6654 Osteogenesis Imperfecta C0029434 Congenital Abnormality; Disease or Syndrome 0.3 0.536 0.655 disease
SOS1 6654 Hypertrophic Cardiomyopathy C0007194 Disease or Syndrome 0.43 0.536 0.655 disease
SOS1 6654 Hydrops Fetalis C0020305 Disease or Syndrome 0.3 0.536 0.655 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
SOS1 6654 IL-6 None None None