ALTITUDEOMICSDB

Hepatocyte growth factor receptor

AltitudeomicsDB

Protein Official symbol	MET
Aliases	MET
Chromosomal Location	7
Length	1390
Uniprot ID	P08581
EC number	2.7.10.1
Protein family Information(Pfam)	PF07714;PF01437;PF01403;PF01833;
PDB id	1FYR;1R0P;1R1W;1SHY;1SSL;1UX3;2G15;2RFN;2RFS;2UZX;2UZY;2WD1;2WGJ;2WKM;3A4P;3BUX;3C1X;3CCN;3CD8;3CE3;3CTH;3CTJ;3DKC;3DKF;3DKG;3EFJ;3EFK;3F66;3F82;3I5N;3L8V;3LQ8;3Q6U;3Q6W;3QTI;3R7O;3RHK;3U6H;3U6I;3VW8;3ZBX;3ZC5;3ZCL;3ZXZ;3ZZE;4AOI;4AP7;4DEG;4DEH;4DEI;4EEV;4GG5;4GG7;4IWD;4K3J;4KNB;4MXC;4O3T;4O3U;4R1V;4R1Y;4XMO;4XYF;5DG5;5EOB;5EYC;5EYD;5HLW;5HNI;5HO6;5HOA;5HOR;5HTI;5LSP;5T3Q;5UAB;5UAD;5YA5;6GCU;6I04;6SD9;6SDC;6SDD;6SDE;6UBW;
InterPro ID	IPR013783;IPR014756;IPR002909;IPR011009;IPR031148;IPR002165;IPR000719;IPR017441;IPR016201;IPR001627;IPR036352;IPR001245;IPR008266;IPR020635;IPR016244;IPR015943;
dbSNP	rs35469582 rs1436957498 rs56311081 rs55985569 rs34349517 rs35225896 rs35776110 rs776693512 rs33917957 rs752055485 rs771333219 rs794728016 rs34589476 rs768678989 rs56391007 rs786202724 rs121913243 rs121913244 rs121913668 rs121913675 rs121913669 rs121913673 rs121913670 rs121913671 rs121913671 rs121913246 rs121913247 rs121913677 rs121913676 rs121913245 rs1263785859

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
SHC1	GRB2	0.997
MET	HGF	0.997
HRAS	PIK3CA	0.995
PTPN11	GAB1	0.995
SOS1	GRB2	0.995
CTNNB1	CDH1	0.995
SEMA4D	PLXNB1	0.994
BCAR1	CRK	0.992
VEGFA	HGF	0.992
BCAR1	SRC	0.992
SRC	STAT3	0.991
CTNND1	CDH1	0.991
VEGFA	STAT3	0.991
PIK3R1	PIK3CA	0.99
PIK3CA	KRAS	0.99
BCAR1	PTK2	0.99
PTPN11	MAPK3	0.987
VEGFA	SRC	0.987
CDC42	SRC	0.986
CTNNB1	CDH2	0.986
SRC	PTPN1	0.986
ITGA6	ITGB1	0.986
SRC	CDH1	0.985
PTPN11	STAT3	0.985
CDC42	MAPK8	0.985
GRB2	MAPK3	0.984
HRAS	SRC	0.983
CDC42	PTK2	0.983
CTNND1	SRC	0.983
STAT3	MAPK1	0.983
PTPN11	MAPK1	0.983
EPS15	HGS	0.982
GRB2	GAB1	0.982
GRB2	MAPK1	0.982
GRB2	GAB2	0.982
GAB2	PTPN11	0.981
ITGB1	ITGA3	0.981
RHOA	CDH1	0.981
STAT3	MAPK3	0.981
RHOA	CTNND1	0.981
HRAS	MAPK3	0.981
SHC1	SOS1	0.981
MET	CDH1	0.98
SOS1	PTPN11	0.98
GRB2	CBL	0.98
CDH1	HGF	0.98
HRAS	PTPN11	0.979
SRC	CTNNB1	0.979
MAPK3	KRAS	0.979
VEGFA	CTNNB1	0.979
HRAS	MAPK1	0.979
RHOA	MAPK1	0.979
CDC42	CDH1	0.978
BCAR1	CRKL	0.977
RHOA	SRC	0.977
SRC	HGF	0.977
SRC	CRK	0.977
PLXNB1	RRAS	0.977
CTNND1	CTNNB1	0.977
STAT3	HGF	0.977
VEGFA	RHOA	0.977
RHOA	MAPK8	0.976
ITGA6	ITGB4	0.976
HRAS	SOS1	0.976
HRAS	GRB2	0.976
NRAS	PTPN11	0.976
RHOA	ARF6	0.975
RHOA	PTK2	0.973
NRAS	MAPK3	0.973
SOS1	KRAS	0.973
CDH1	MAPK1	0.973
KRAS	MAPK1	0.973
SRC	GAB1	0.973
PTPN11	KRAS	0.972
RHOA	MAPK3	0.972
PIK3R1	HRAS	0.972
VEGFA	CDC42	0.971
GRB2	HGF	0.971
SHC1	INPPL1	0.971
ITGB1	ITGA2	0.971
SRC	KRAS	0.971
SHC1	MAPK3	0.971
CTNNB1	PIK3CA	0.971
GRB2	KRAS	0.971
SOS1	SRC	0.97
NRAS	MAPK1	0.97
CTNND1	CDH2	0.97
SH3KBP1	CBL	0.969
GRB2	PTPN1	0.969
RHOA	PLXNB1	0.969
HRAS	HGF	0.968
SHC1	MAPK1	0.968
CRK	GAB1	0.968
NRAS	PIK3CA	0.968
PTK2	PTPN11	0.968
KRAS	HGF	0.968
MAPK8	CRK	0.967
RHOA	PTPN11	0.967
PTK2	HGF	0.967
PTPRJ	SRC	0.966
MAPK3	CDH1	0.966
MET	KRAS	0.966
SRC	CBL	0.966
PTK2	CRK	0.965
SOS1	MAPK3	0.965
HRAS	SHC1	0.965
GRB2	NRAS	0.965
HRAS	MET	0.965
SOS1	NRAS	0.964
MET	STAT3	0.964
SDC1	HGF	0.964
SHC1	MAPK8	0.964
CDC42	CTNND1	0.964
SOS1	MAPK1	0.963
VEGFA	PTK2	0.963
CDC42	CRK	0.963
SH3KBP1	MET	0.963
MAPK3	HGF	0.963
PTPN1	CRK	0.962
SHC1	HGF	0.962
GRB2	PTK2	0.96
BCAR1	CDC42	0.959
GRB2	STAT3	0.959
RHOA	CTNNB1	0.959
CTNNB1	MET	0.959
CRK	CBL	0.958
SHC1	PTK2	0.958
PIK3R1	STAT3	0.958
ITGB1	PTK2	0.958
RHOA	BCAR1	0.957
GAB2	MAPK1	0.957
MET	PIK3CA	0.957
CDC42	CDH2	0.957
RHOA	CDH2	0.957
SRC	PIK3CA	0.956
SHC1	GAB1	0.956
GRB2	MET	0.956
SHC1	KRAS	0.956
SHC1	CBL	0.956
MAPK3	PLCG1	0.956
PTPN11	CBL	0.956
EPS15	ARF6	0.956
ARF6	HGF	0.955
BCAR1	PTPN11	0.955
PIK3R1	GRB2	0.955
CDC42	CTNNB1	0.955
VEGFA	ITGB1	0.955
HRAS	ITGA6	0.954
ITGB1	HGF	0.954
SOS1	CDC42	0.954
CRKL	CBL	0.954
RHOA	GRB2	0.954
ITGA6	CDH1	0.953
RHOA	CRK	0.953
PIK3R1	SRC	0.952
PTPN1	CTNNB1	0.952
HRAS	PTK2	0.952
SEMA4D	RRAS	0.952
SEMA4D	RHOA	0.951
GAB1	HGF	0.951
SHC1	GAB2	0.951
VEGFA	PIK3CA	0.951
HGF	MAPK1	0.951
SH3GL3	MET	0.951
PIK3R1	KRAS	0.951
SRC	ARF6	0.95
CDC42	DOCK7	0.95
MET	CDH2	0.95
PLAUR	HGF	0.95
CDC42	ITGB1	0.95
GAB2	CRKL	0.949
MET	GAB1	0.949
MAPK8	HGF	0.949
PIK3CA	CDH1	0.949
PTPN11	PIK3CA	0.948
CTNNB1	HGF	0.948
VEGFA	GRB2	0.948
PTK2	KRAS	0.948
PIK3R1	CTNNB1	0.948
SOS1	CBL	0.947
MAPK8	SRC	0.947
VEGFA	SHC1	0.947
SRC	NRAS	0.947
SRC	PLAUR	0.947
ITGB1	SRC	0.947
GRB2	EPS15	0.947
PTPN11	MET	0.947
ITGB4	ITGA3	0.947
CTNNB1	PTPN11	0.947
MET	INPPL1	0.946
BCAR1	PTPN1	0.946
MAPK3	GAB1	0.945
SH3KBP1	EPS15	0.945
CDC42	HGF	0.945
PTK2	ITGA3	0.945
RHOA	SOS1	0.945
SHC1	RHOA	0.944
VEGFA	PTPN11	0.944
BCAR1	ITGB1	0.944
NRAS	MET	0.944
SOS1	RRAS	0.944
BCAR1	MAPK8	0.943
SHC1	MET	0.943
GRB2	PIK3CA	0.943
STAT3	PIK3CA	0.943
SRC	PTPN11	0.943
CDC42	CBL	0.943
EPS15	CBL	0.943
PIK3R1	SOS1	0.943
SRC	RRAS	0.943
PIK3R1	PTPN11	0.943
PLAUR	MET	0.943
SEMA4D	MET	0.943
MET	CRK	0.942
CBL	PLCG1	0.942
CDH1	ITGB4	0.942
EPS15	SH3GL3	0.941
SRC	MAPK3	0.941
SHC1	SRC	0.941
CDC42	MET	0.941
GAB2	CRK	0.941
RHOA	ITGB1	0.941
RRAS	MAPK1	0.94
SOS1	PLCG1	0.94
SRC	MAPK1	0.94
PTPN11	HGF	0.939
BCAR1	CBL	0.939
VEGFA	BCAR1	0.939
RHOA	MET	0.939
PIK3R1	SHC1	0.939
HRAS	MAPK8	0.938
GRB2	PTPN11	0.938
SDC1	MAPK3	0.938
SHC1	PTPN1	0.938
PIK3R1	CDC42	0.938
SDC1	ITGA2	0.938
BCAR1	MET	0.937
MET	CBL	0.937
CRKL	PTK2	0.937
ITGA6	MET	0.937
PIK3CA	HGF	0.937
ITGB1	SDC1	0.937
SOS1	PTK2	0.937
SRC	PLCG1	0.936
ITGB1	MET	0.936
SDC1	MET	0.936
ITGA2	ITGA3	0.935
CTNND1	MET	0.935
CRK	HGF	0.935
PTK2	ITGA2	0.935
GAB1	MAPK1	0.935
VEGFA	PLCG1	0.935
SOS1	PIK3CA	0.934
NRAS	HGF	0.934
LRIG1	CBL	0.934
CRK	ARF6	0.934
GAB2	MAPK3	0.934
HGS	CBL	0.933
CDC42	SH3KBP1	0.933
HRAS	GAB1	0.933
ITGB1	STAT3	0.933
PIK3R1	NRAS	0.932
SHC1	PTPN11	0.932
PTK2	MAPK3	0.932
PLXNB1	MET	0.932
PIK3R1	CRK	0.932
RHOA	PIK3CA	0.932
SOS1	GAB1	0.932
ARF6	MAPK3	0.931
MAPK8	CRKL	0.931
SHC1	PIK3CA	0.931
PTPN1	MET	0.93
PTK2	PLCG1	0.93
SH3KBP1	SH3GL3	0.93
VEGFA	PTPRJ	0.93
PTPN11	CRK	0.93
CTNND1	PTPN11	0.93
SH3GL3	CBL	0.93
SRC	CRKL	0.93
CRKL	GAB1	0.929
PTK2	MAPK1	0.929
MAPK8	KRAS	0.929
CRKL	MET	0.929
VEGFA	MET	0.929
PTK2	PIK3CA	0.929
CBL	HGF	0.929
GRB2	RRAS	0.929
BCAR1	HGF	0.929
PTPRJ	MET	0.929
PIK3R1	CRKL	0.928
CDC42	PLCG1	0.928
CTNND1	HGF	0.928
PIK3CA	PLCG1	0.928
VEGFA	PIK3R1	0.928
VEGFA	SOS1	0.928
CDC42	PIK3CA	0.928
RHOA	PTPN1	0.928
RHOA	CDC42	0.928
GRB2	SRC	0.928
MET	RRAS	0.928
SHC1	NRAS	0.928
ITGB1	GRB2	0.928
GRB2	PLCG1	0.927
SDC1	MAPK1	0.927
MET	MAPK3	0.927
ITGB1	PLAUR	0.927
GRB2	HGS	0.926
CRKL	PTPN11	0.926
SRC	PTK2	0.926
PLAUR	ITGA3	0.926
NRAS	GAB2	0.926
HRAS	GAB2	0.926
SRC	MET	0.926
GAB1	PLCG1	0.925
GAB2	MET	0.925
NRAS	PTK2	0.925
PIK3R1	GAB2	0.925
SRC	HGS	0.925
CRK	DOCK7	0.925
GRB2	CRKL	0.925
PTK2	MET	0.924
RHOA	KRAS	0.924
HRAS	RHOA	0.924
SOS1	GAB2	0.923
GAB2	PIK3CA	0.923
PIK3R1	MET	0.923
PTPN1	CDH2	0.923
MET	ITGA3	0.923
CRKL	HGF	0.923
SDC1	ITGB4	0.923
MET	LRIG1	0.922
MAPK8	GAB1	0.922
INPPL1	PIK3CA	0.922
SHC1	ITGB4	0.922
SHC1	ITGB1	0.922
ITGA6	SDC1	0.922
RHOA	NRAS	0.921
ARF6	MAPK1	0.921
MET	ITGB4	0.921
PIK3R1	RHOA	0.921
SOS1	MET	0.921
PTPN1	HGF	0.921
CDH2	PIK3CA	0.921
VEGFA	ITGA3	0.921
GRB2	ITGB4	0.921
VEGFA	CBL	0.921
MET	PLCG1	0.921
MET	DOCK7	0.921
PTK2	RRAS	0.921
MET	ITGA2	0.921
CRKL	PIK3CA	0.92
HRAS	ITGB4	0.92
GAB2	HGF	0.92
CRKL	ARF6	0.92
PIK3R1	PTPN1	0.92
MET	ARF6	0.92
HGS	HGF	0.92
MET	MAPK1	0.92
EPS15	MET	0.92
MAPK8	MET	0.92
PIK3R1	PLCG1	0.92
HGS	MET	0.919
RHOA	GAB2	0.919
MAPK8	MAPK3	0.919
ITGB1	PIK3CA	0.919
PTPN11	CDH2	0.919
PIK3R1	CDH1	0.918
MAPK8	MAPK1	0.918
ITGB1	ARF6	0.917
HGS	CDH1	0.917
SH3KBP1	HGS	0.917
PIK3R1	PTK2	0.917
PIK3R1	CBL	0.917
ITGA2	HGF	0.916
VEGFA	GAB1	0.915
SOS1	SH3KBP1	0.915
EPS15	HGF	0.915
SOS1	HGF	0.915
PIK3R1	GAB1	0.915
GAB2	KRAS	0.915
PIK3R1	ITGB1	0.915
ITGA6	PIK3CA	0.915
INPPL1	HGF	0.914
CRK	PIK3CA	0.913
PIK3R1	ITGB4	0.912
ITGB1	CRKL	0.912
PIK3R1	BCAR1	0.912
ITGA6	ITGA3	0.912
SHC1	ITGA6	0.912
PIK3R1	SH3KBP1	0.912
ITGB1	ITGB4	0.911
SH3KBP1	LRIG1	0.911
PTPN1	PIK3CA	0.911
ITGA2	ITGB4	0.911
PIK3R1	HGF	0.91
PIK3R1	ITGA6	0.91
PLCG1	HGF	0.91
SH3KBP1	HGF	0.91
LRIG1	HGF	0.91
PTPRJ	CTNNB1	0.91
HGF	ITGA3	0.909
HGS	LRIG1	0.909
PIK3CA	GAB1	0.909
SH3KBP1	PLCG1	0.909
BCAR1	PIK3CA	0.908
PIK3R1	CDH2	0.908
CRKL	DOCK7	0.908
CTNNB1	HGS	0.908
ITGA6	GRB2	0.908
GAB2	GAB1	0.907
CDH2	CDH1	0.907
CBL	PIK3CA	0.907
CTNND1	PIK3CA	0.907
PTPRJ	HGF	0.907
HGS	SH3GL3	0.906
CRKL	CRK	0.906
PIK3CA	ITGB4	0.906
EPS15	LRIG1	0.905
MAPK8	NRAS	0.905
NRAS	KRAS	0.904
PIK3R1	ARF6	0.904
CDC42	SH3GL3	0.904
PTPRJ	PLAUR	0.904
SOS1	ITGB1	0.904
HRAS	NRAS	0.902
HRAS	KRAS	0.902
MAPK3	MAPK1	0.902
GAB1	DOCK7	0.902
SH3GL3	LRIG1	0.901
ARF6	ITGA2	0.901
ARF6	ITGA3	0.9
ITGA6	ARF6	0.9
PIK3R1	CTNND1	0.9
ARF6	GAB1	0.9
SH3GL3	HGF	0.9
DOCK7	HGF	0.9
SOS1	HGS	0.9
ARF6	PIK3CA	0.9

Gene Ontology Semantic Similarity

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#	2885 (GRB2)	3082 (HGF)	5290 (PIK3CA)	2549 (GAB1)	999 (CDH1)	5364 (PLXNB1)	1398 (CRK)	6714 (SRC)	6774 (STAT3)	3845 (KRAS)	5747 (PTK2)	5595 (MAPK3)	1000 (CDH2)	5770 (PTPN1)	3688 (ITGB1)	5599 (MAPK8)	5594 (MAPK1)	9146 (HGS)	9846 (GAB2)	5781 (PTPN11)	3675 (ITGA3)	1500 (CTNND1)	6654 (SOS1)	867 (CBL)	1499 (CTNNB1)	1399 (CRKL)	6237 (RRAS)	387 (RHOA)	3691 (ITGB4)	382 (ARF6)	3265 (HRAS)	998 (CDC42)	3636 (INPPL1)	3673 (ITGA2)	6464 (SHC1)	4893 (NRAS)	4233 (MET)	9564 (BCAR1)	5335 (PLCG1)	3655 (ITGA6)	85440 (DOCK7)	5329 (PLAUR)	2060 (EPS15)	6457 (SH3GL3)	6382 (SDC1)	30011 (SH3KBP1)	5795 (PTPRJ)	5295 (PIK3R1)	10507 (SEMA4D)	7422 (VEGFA)
2885 (GRB2)	1.00	0.72	0.72	0.77	0.66	0.53	0.77	0.77	0.59	0.58	0.73	0.66	0.62	0.68	0.60	0.63	0.65	0.61	0.64	0.74	0.59	0.62	0.65	0.64	0.63	0.75	0.54	0.59	0.59	0.54	0.53	0.64	0.53	0.54	0.77	0.58	0.71	0.63	0.62	0.59	0.57	0.61	0.59	0.62	0.63	1.00	0.63	0.74	0.58	0.62
3082 (HGF)	0.72	1.00	0.69	0.66	0.64	0.46	0.57	0.74	0.48	0.50	0.75	0.68	0.59	0.52	0.57	0.64	0.69	0.54	0.54	0.58	0.53	0.56	0.63	0.52	0.60	0.56	0.46	0.47	0.54	0.46	0.45	0.60	0.46	0.48	0.59	0.50	0.78	0.50	0.46	0.53	0.49	0.54	0.52	0.56	0.58	1.00	0.55	0.63	0.53	0.66
5290 (PIK3CA)	0.72	0.69	1.00	0.86	0.58	0.37	0.53	0.77	0.41	0.41	0.67	0.79	0.54	0.46	0.53	0.73	0.78	0.47	0.69	0.68	0.45	0.47	0.32	0.53	0.57	0.48	0.36	0.39	0.47	0.37	0.36	0.61	0.37	0.41	0.46	0.41	0.68	0.41	0.37	0.47	0.39	0.46	0.44	0.44	0.48	1.00	0.50	0.69	0.44	0.52
2549 (GAB1)	0.77	0.66	0.86	1.00	0.67	0.45	0.69	0.76	0.46	0.56	0.63	0.69	0.64	0.53	0.60	0.63	0.68	0.61	0.70	0.73	0.60	0.61	0.40	0.54	0.63	0.67	0.46	0.48	0.59	0.47	0.45	0.58	0.46	0.50	0.54	0.56	0.65	0.56	0.46	0.60	0.54	0.56	0.58	0.60	0.63	1.00	0.56	0.70	0.52	0.57
999 (CDH1)	0.66	0.64	0.58	0.67	1.00	0.65	0.73	0.66	0.62	0.76	0.63	0.69	0.95	0.73	0.75	0.61	0.66	0.77	0.64	0.58	0.76	0.81	0.63	0.69	0.72	0.79	0.68	0.69	0.74	0.68	0.66	0.65	0.68	0.66	0.65	0.76	0.61	0.76	0.66	0.79	0.75	0.71	0.80	0.81	0.81	1.00	0.72	0.61	0.67	0.71
5364 (PLXNB1)	0.53	0.46	0.37	0.45	0.65	1.00	0.59	0.55	0.48	0.53	0.47	0.48	0.60	0.52	0.70	0.48	0.46	0.57	0.44	0.42	0.55	0.58	0.57	0.49	0.61	0.55	0.46	0.48	0.56	0.47	0.45	0.48	0.46	0.68	0.53	0.53	0.67	0.53	0.46	0.56	0.51	0.82	0.54	0.55	0.58	1.00	0.54	0.53	0.84	0.57
1398 (CRK)	0.77	0.57	0.53	0.69	0.73	0.59	1.00	0.71	0.57	0.71	0.65	0.61	0.72	0.72	0.67	0.57	0.58	0.76	0.61	0.67	0.72	0.75	0.58	0.72	0.69	0.81	0.63	0.67	0.70	0.63	0.61	0.62	0.68	0.62	0.74	0.71	0.54	0.77	0.66	0.71	0.70	0.71	0.71	0.74	0.74	1.00	0.70	0.64	0.65	0.64
6714 (SRC)	0.77	0.74	0.77	0.76	0.66	0.55	0.71	1.00	0.55	0.59	0.80	0.77	0.64	0.66	0.66	0.76	0.77	0.62	0.66	0.72	0.61	0.67	0.53	0.67	0.69	0.67	0.56	0.58	0.65	0.57	0.57	0.71	0.59	0.57	0.64	0.59	0.74	0.61	0.58	0.63	0.59	0.65	0.63	0.60	0.63	1.00	0.63	0.70	0.62	0.64
6774 (STAT3)	0.59	0.48	0.41	0.46	0.62	0.48	0.57	0.55	1.00	0.51	0.54	0.51	0.58	0.60	0.56	0.46	0.50	0.52	0.46	0.47	0.52	0.52	0.44	0.63	0.64	0.60	0.48	0.51	0.51	0.47	0.47	0.53	0.46	0.49	0.52	0.51	0.50	0.54	0.50	0.52	0.49	0.53	0.51	0.53	0.55	1.00	0.56	0.53	0.51	0.58
3845 (KRAS)	0.58	0.50	0.41	0.56	0.76	0.53	0.71	0.59	0.51	1.00	0.53	0.57	0.75	0.61	0.72	0.49	0.52	0.82	0.52	0.46	0.79	0.82	0.49	0.57	0.71	0.70	0.72	0.59	0.72	0.59	0.55	0.54	0.58	0.67	0.59	1.00	0.47	0.80	0.56	0.76	0.76	0.68	0.78	0.85	0.84	1.00	0.64	0.55	0.61	0.62
5747 (PTK2)	0.73	0.75	0.67	0.63	0.63	0.47	0.65	0.80	0.54	0.53	1.00	0.75	0.60	0.60	0.60	0.73	0.75	0.57	0.58	0.61	0.55	0.56	0.63	0.57	0.65	0.55	0.47	0.56	0.55	0.48	0.47	0.69	0.52	0.49	0.62	0.53	0.80	0.62	0.55	0.55	0.52	0.57	0.54	0.55	0.57	1.00	0.62	0.65	0.52	0.56
5595 (MAPK3)	0.66	0.68	0.79	0.69	0.69	0.48	0.61	0.77	0.51	0.57	0.75	1.00	0.64	0.55	0.61	0.88	0.99	0.61	0.61	0.58	0.59	0.61	0.43	0.59	0.64	0.61	0.49	0.51	0.58	0.50	0.48	0.71	0.50	0.51	0.53	0.57	0.71	0.57	0.49	0.59	0.55	0.59	0.58	0.64	0.66	1.00	0.58	0.63	0.55	0.60
1000 (CDH2)	0.62	0.59	0.54	0.64	0.95	0.60	0.72	0.64	0.58	0.75	0.60	0.64	1.00	0.72	0.72	0.57	0.61	0.77	0.61	0.55	0.76	0.82	0.59	0.67	0.73	0.76	0.65	0.67	0.73	0.66	0.63	0.61	0.65	0.64	0.63	0.75	0.56	0.75	0.63	0.79	0.74	0.70	0.80	0.79	0.79	1.00	0.71	0.59	0.65	0.68
5770 (PTPN1)	0.68	0.52	0.46	0.53	0.73	0.52	0.72	0.66	0.60	0.61	0.60	0.55	0.72	1.00	0.65	0.54	0.53	0.65	0.55	0.70	0.64	0.71	0.49	0.69	0.70	0.73	0.55	0.64	0.62	0.58	0.55	0.60	0.63	0.55	0.67	0.61	0.49	0.70	0.66	0.67	0.60	0.65	0.67	0.63	0.64	1.00	0.79	0.57	0.59	0.60
3688 (ITGB1)	0.60	0.57	0.53	0.60	0.75	0.70	0.67	0.66	0.56	0.72	0.60	0.61	0.72	0.65	1.00	0.57	0.58	0.69	0.58	0.56	0.75	0.73	0.57	0.63	0.71	0.69	0.66	0.61	0.72	0.61	0.59	0.58	0.61	0.76	0.62	0.72	0.61	0.67	0.60	0.71	0.66	0.76	0.71	0.68	0.69	1.00	0.63	0.60	0.72	0.67
5599 (MAPK8)	0.63	0.64	0.73	0.63	0.61	0.48	0.57	0.76	0.46	0.49	0.73	0.88	0.57	0.54	0.57	1.00	0.88	0.54	0.56	0.55	0.53	0.52	0.48	0.55	0.62	0.52	0.43	0.46	0.52	0.46	0.43	0.68	0.44	0.47	0.52	0.49	0.66	0.50	0.45	0.52	0.48	0.56	0.51	0.51	0.54	1.00	0.54	0.64	0.51	0.55
5594 (MAPK1)	0.65	0.69	0.78	0.68	0.66	0.46	0.58	0.77	0.50	0.52	0.75	0.99	0.61	0.53	0.58	0.88	1.00	0.56	0.60	0.57	0.55	0.56	0.41	0.57	0.62	0.57	0.46	0.47	0.55	0.46	0.45	0.72	0.46	0.48	0.51	0.52	0.71	0.52	0.46	0.55	0.50	0.56	0.54	0.58	0.61	1.00	0.55	0.63	0.52	0.58
9146 (HGS)	0.61	0.54	0.47	0.61	0.77	0.57	0.76	0.62	0.52	0.82	0.57	0.61	0.77	0.65	0.69	0.54	0.56	1.00	0.57	0.50	0.82	0.84	0.54	0.62	0.70	0.73	0.63	0.63	0.75	0.64	0.60	0.59	0.66	0.62	0.61	0.82	0.50	0.82	0.60	0.78	0.79	0.76	0.80	0.86	0.86	1.00	0.67	0.57	0.64	0.64
9846 (GAB2)	0.64	0.54	0.69	0.70	0.64	0.44	0.61	0.66	0.46	0.52	0.58	0.61	0.61	0.55	0.58	0.56	0.60	0.57	1.00	0.57	0.55	0.58	0.38	0.55	0.62	0.57	0.44	0.48	0.55	0.45	0.44	0.54	0.44	0.49	0.68	0.52	0.54	0.54	0.45	0.56	0.50	0.54	0.54	0.55	0.58	1.00	0.55	0.67	0.51	0.57
5781 (PTPN11)	0.74	0.58	0.68	0.73	0.58	0.42	0.67	0.72	0.47	0.46	0.61	0.58	0.55	0.70	0.56	0.55	0.57	0.50	0.57	1.00	0.49	0.51	0.38	0.51	0.59	0.60	0.44	0.51	0.52	0.44	0.43	0.57	0.56	0.46	0.58	0.46	0.56	0.53	0.57	0.49	0.45	0.50	0.48	0.48	0.51	1.00	0.77	0.68	0.48	0.53
3675 (ITGA3)	0.59	0.53	0.45	0.60	0.76	0.55	0.72	0.61	0.52	0.79	0.55	0.59	0.76	0.64	0.75	0.53	0.55	0.82	0.55	0.49	1.00	0.81	0.52	0.59	0.70	0.71	0.61	0.62	0.73	0.63	0.58	0.57	0.61	0.60	0.60	0.79	0.49	0.80	0.59	0.77	0.77	0.71	0.78	0.84	0.84	1.00	0.66	0.56	0.63	0.67
1500 (CTNND1)	0.62	0.56	0.47	0.61	0.81	0.58	0.75	0.67	0.52	0.82	0.56	0.61	0.82	0.71	0.73	0.52	0.56	0.84	0.58	0.51	0.81	1.00	0.54	0.69	0.74	0.80	0.63	0.63	0.79	0.64	0.60	0.58	0.63	0.62	0.68	0.82	0.50	0.82	0.62	0.87	0.79	0.74	0.90	0.86	0.86	1.00	0.68	0.61	0.71	0.69
6654 (SOS1)	0.65	0.63	0.32	0.40	0.63	0.57	0.58	0.53	0.44	0.49	0.63	0.43	0.59	0.49	0.57	0.48	0.41	0.54	0.38	0.38	0.52	0.54	1.00	0.46	0.60	0.53	0.41	0.44	0.53	0.42	0.41	0.45	0.41	0.46	0.67	0.49	0.58	0.49	0.41	0.53	0.47	0.51	0.51	0.52	0.55	1.00	0.52	0.53	0.49	0.56
867 (CBL)	0.64	0.52	0.53	0.54	0.69	0.49	0.72	0.67	0.63	0.57	0.57	0.59	0.67	0.69	0.63	0.55	0.57	0.62	0.55	0.51	0.59	0.69	0.46	1.00	0.65	0.63	0.51	0.55	0.59	0.51	0.50	0.67	0.52	0.52	0.65	0.57	0.50	0.61	0.53	0.65	0.56	0.60	0.64	0.60	0.62	1.00	0.61	0.57	0.57	0.59
1499 (CTNNB1)	0.63	0.60	0.57	0.63	0.72	0.61	0.69	0.69	0.64	0.71	0.65	0.64	0.73	0.70	0.71	0.62	0.62	0.70	0.62	0.59	0.70	0.74	0.60	0.65	1.00	0.70	0.66	0.65	0.68	0.65	0.64	0.63	0.63	0.65	0.63	0.71	0.60	0.70	0.64	0.71	0.68	0.70	0.71	0.69	0.72	1.00	0.67	0.65	0.65	0.64
1399 (CRKL)	0.75	0.56	0.48	0.67	0.79	0.55	0.81	0.67	0.60	0.70	0.55	0.61	0.76	0.73	0.69	0.52	0.57	0.73	0.57	0.60	0.71	0.80	0.53	0.63	0.70	1.00	0.60	0.61	0.69	0.61	0.59	0.59	0.59	0.59	0.65	0.70	0.53	0.70	0.58	0.76	0.69	0.65	0.77	0.78	0.78	1.00	0.63	0.61	0.61	0.64
6237 (RRAS)	0.54	0.46	0.36	0.46	0.68	0.46	0.63	0.56	0.48	0.72	0.47	0.49	0.65	0.55	0.66	0.43	0.46	0.63	0.44	0.44	0.61	0.63	0.41	0.51	0.66	0.60	1.00	0.85	0.60	0.88	0.92	0.72	0.49	0.59	0.54	0.72	0.42	0.58	0.49	0.61	0.56	0.57	0.60	0.62	0.65	1.00	0.59	0.51	0.53	0.59
387 (RHOA)	0.59	0.47	0.39	0.48	0.69	0.48	0.67	0.58	0.51	0.59	0.56	0.51	0.67	0.64	0.61	0.46	0.47	0.63	0.48	0.51	0.62	0.63	0.44	0.55	0.65	0.61	0.85	1.00	0.61	0.89	0.90	0.78	0.51	0.53	0.58	0.59	0.44	0.71	0.59	0.62	0.58	0.59	0.61	0.63	0.65	1.00	0.68	0.52	0.54	0.59
3691 (ITGB4)	0.59	0.54	0.47	0.59	0.74	0.56	0.70	0.65	0.51	0.72	0.55	0.58	0.73	0.62	0.72	0.52	0.55	0.75	0.55	0.52	0.73	0.79	0.53	0.59	0.68	0.69	0.60	0.61	1.00	0.61	0.57	0.56	0.60	0.61	0.63	0.72	0.50	0.73	0.58	0.88	0.71	0.69	0.73	0.76	0.76	1.00	0.64	0.58	0.64	0.63
382 (ARF6)	0.54	0.46	0.37	0.47	0.68	0.47	0.63	0.57	0.47	0.59	0.48	0.50	0.66	0.58	0.61	0.46	0.46	0.64	0.45	0.44	0.63	0.64	0.42	0.51	0.65	0.61	0.88	0.89	0.61	1.00	0.93	0.78	0.50	0.52	0.54	0.59	0.43	0.60	0.50	0.62	0.57	0.60	0.61	0.63	0.66	1.00	0.60	0.51	0.54	0.59
3265 (HRAS)	0.53	0.45	0.36	0.45	0.66	0.45	0.61	0.57	0.47	0.55	0.47	0.48	0.63	0.55	0.59	0.43	0.45	0.60	0.44	0.43	0.58	0.60	0.41	0.50	0.64	0.59	0.92	0.90	0.57	0.93	1.00	0.76	0.48	0.52	0.54	0.55	0.42	0.55	0.48	0.58	0.53	0.55	0.57	0.58	0.66	1.00	0.57	0.50	0.52	0.59
998 (CDC42)	0.64	0.60	0.61	0.58	0.65	0.48	0.62	0.71	0.53	0.54	0.69	0.71	0.61	0.60	0.58	0.68	0.72	0.59	0.54	0.57	0.57	0.58	0.45	0.67	0.63	0.59	0.72	0.78	0.56	0.78	0.76	1.00	0.50	0.51	0.56	0.54	0.60	0.61	0.55	0.57	0.53	0.59	0.56	0.59	0.61	1.00	0.63	0.57	0.53	0.59
3636 (INPPL1)	0.53	0.46	0.37	0.46	0.68	0.46	0.68	0.59	0.46	0.58	0.52	0.50	0.65	0.63	0.61	0.44	0.46	0.66	0.44	0.56	0.61	0.63	0.41	0.52	0.63	0.59	0.49	0.51	0.60	0.50	0.48	0.50	1.00	0.51	0.53	0.58	0.42	0.59	0.57	0.61	0.56	0.59	0.60	0.62	0.65	1.00	0.72	0.51	0.54	0.58
3673 (ITGA2)	0.54	0.48	0.41	0.50	0.66	0.68	0.62	0.57	0.49	0.67	0.49	0.51	0.64	0.55	0.76	0.47	0.48	0.62	0.49	0.46	0.60	0.62	0.46	0.52	0.65	0.59	0.59	0.53	0.61	0.52	0.52	0.51	0.51	1.00	0.56	0.67	0.59	0.59	0.50	0.60	0.57	0.69	0.60	0.61	0.63	1.00	0.57	0.54	0.68	0.60
6464 (SHC1)	0.77	0.59	0.46	0.54	0.65	0.53	0.74	0.64	0.52	0.59	0.62	0.53	0.63	0.67	0.62	0.52	0.51	0.61	0.68	0.58	0.60	0.68	0.67	0.65	0.63	0.65	0.54	0.58	0.63	0.54	0.54	0.56	0.53	0.56	1.00	0.59	0.56	0.63	0.62	0.60	0.58	0.64	0.60	0.61	0.62	1.00	0.62	0.73	0.61	0.63
4893 (NRAS)	0.58	0.50	0.41	0.56	0.76	0.53	0.71	0.59	0.51	1.00	0.53	0.57	0.75	0.61	0.72	0.49	0.52	0.82	0.52	0.46	0.79	0.82	0.49	0.57	0.71	0.70	0.72	0.59	0.72	0.59	0.55	0.54	0.58	0.67	0.59	1.00	0.47	0.80	0.56	0.76	0.76	0.68	0.78	0.85	0.84	1.00	0.64	0.55	0.61	0.62
4233 (MET)	0.71	0.78	0.68	0.65	0.61	0.67	0.54	0.74	0.50	0.47	0.80	0.71	0.56	0.49	0.61	0.66	0.71	0.50	0.54	0.56	0.49	0.50	0.58	0.50	0.60	0.53	0.42	0.44	0.50	0.43	0.42	0.60	0.42	0.59	0.56	0.47	1.00	0.47	0.42	0.50	0.46	0.66	0.49	0.52	0.54	1.00	0.51	0.65	0.67	0.56
9564 (BCAR1)	0.63	0.50	0.41	0.56	0.76	0.53	0.77	0.61	0.54	0.80	0.62	0.57	0.75	0.70	0.67	0.50	0.52	0.82	0.54	0.53	0.80	0.82	0.49	0.61	0.70	0.70	0.58	0.71	0.73	0.60	0.55	0.61	0.59	0.59	0.63	0.80	0.47	1.00	0.67	0.76	0.76	0.69	0.78	0.85	0.85	1.00	0.75	0.56	0.61	0.62
5335 (PLCG1)	0.62	0.46	0.37	0.46	0.66	0.46	0.66	0.58	0.50	0.56	0.55	0.49	0.63	0.66	0.60	0.45	0.46	0.60	0.45	0.57	0.59	0.62	0.41	0.53	0.64	0.58	0.49	0.59	0.58	0.50	0.48	0.55	0.57	0.50	0.62	0.56	0.42	0.67	1.00	0.59	0.54	0.58	0.58	0.59	0.62	1.00	0.74	0.56	0.53	0.57
3655 (ITGA6)	0.59	0.53	0.47	0.60	0.79	0.56	0.71	0.63	0.52	0.76	0.55	0.59	0.79	0.67	0.71	0.52	0.55	0.78	0.56	0.49	0.77	0.87	0.53	0.65	0.71	0.76	0.61	0.62	0.88	0.62	0.58	0.57	0.61	0.60	0.60	0.76	0.50	0.76	0.59	1.00	0.74	0.68	0.84	0.80	0.80	1.00	0.65	0.56	0.63	0.63
85440 (DOCK7)	0.57	0.49	0.39	0.54	0.75	0.51	0.70	0.59	0.49	0.76	0.52	0.55	0.74	0.60	0.66	0.48	0.50	0.79	0.50	0.45	0.77	0.79	0.47	0.56	0.68	0.69	0.56	0.58	0.71	0.57	0.53	0.53	0.56	0.57	0.58	0.76	0.46	0.76	0.54	0.74	1.00	0.67	0.75	0.82	0.82	1.00	0.63	0.54	0.59	0.62
5329 (PLAUR)	0.61	0.54	0.46	0.56	0.71	0.82	0.71	0.65	0.53	0.68	0.57	0.59	0.70	0.65	0.76	0.56	0.56	0.76	0.54	0.50	0.71	0.74	0.51	0.60	0.70	0.65	0.57	0.59	0.69	0.60	0.55	0.59	0.59	0.69	0.64	0.68	0.66	0.69	0.58	0.68	0.67	1.00	0.68	0.71	0.72	1.00	0.64	0.59	0.87	0.66
2060 (EPS15)	0.59	0.52	0.44	0.58	0.80	0.54	0.71	0.63	0.51	0.78	0.54	0.58	0.80	0.67	0.71	0.51	0.54	0.80	0.54	0.48	0.78	0.90	0.51	0.64	0.71	0.77	0.60	0.61	0.73	0.61	0.57	0.56	0.60	0.60	0.60	0.78	0.49	0.78	0.58	0.84	0.75	0.68	1.00	0.82	0.82	1.00	0.65	0.56	0.62	0.63
6457 (SH3GL3)	0.62	0.56	0.44	0.60	0.81	0.55	0.74	0.60	0.53	0.85	0.55	0.64	0.79	0.63	0.68	0.51	0.58	0.86	0.55	0.48	0.84	0.86	0.52	0.60	0.69	0.78	0.62	0.63	0.76	0.63	0.58	0.59	0.62	0.61	0.61	0.85	0.52	0.85	0.59	0.80	0.82	0.71	0.82	1.00	0.96	1.00	0.66	0.56	0.63	0.66
6382 (SDC1)	0.63	0.58	0.48	0.63	0.81	0.58	0.74	0.63	0.55	0.84	0.57	0.66	0.79	0.64	0.69	0.54	0.61	0.86	0.58	0.51	0.84	0.86	0.55	0.62	0.72	0.78	0.65	0.65	0.76	0.66	0.66	0.61	0.65	0.63	0.62	0.84	0.54	0.85	0.62	0.80	0.82	0.72	0.82	0.96	1.00	1.00	0.68	0.58	0.65	0.67
30011 (SH3KBP1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
5795 (PTPRJ)	0.63	0.55	0.50	0.56	0.72	0.54	0.70	0.63	0.56	0.64	0.62	0.58	0.71	0.79	0.63	0.54	0.55	0.67	0.55	0.77	0.66	0.68	0.52	0.61	0.67	0.63	0.59	0.68	0.64	0.60	0.57	0.63	0.72	0.57	0.62	0.64	0.51	0.75	0.74	0.65	0.63	0.64	0.65	0.66	0.68	1.00	1.00	0.56	0.60	0.66
5295 (PIK3R1)	0.74	0.63	0.69	0.70	0.61	0.53	0.64	0.70	0.53	0.55	0.65	0.63	0.59	0.57	0.60	0.64	0.63	0.57	0.67	0.68	0.56	0.61	0.53	0.57	0.65	0.61	0.51	0.52	0.58	0.51	0.50	0.57	0.51	0.54	0.73	0.55	0.65	0.56	0.56	0.56	0.54	0.59	0.56	0.56	0.58	1.00	0.56	1.00	0.57	0.57
10507 (SEMA4D)	0.58	0.53	0.44	0.52	0.67	0.84	0.65	0.62	0.51	0.61	0.52	0.55	0.65	0.59	0.72	0.51	0.52	0.64	0.51	0.48	0.63	0.71	0.49	0.57	0.65	0.61	0.53	0.54	0.64	0.54	0.52	0.53	0.54	0.68	0.61	0.61	0.67	0.61	0.53	0.63	0.59	0.87	0.62	0.63	0.65	1.00	0.60	0.57	1.00	0.65
7422 (VEGFA)	0.62	0.66	0.52	0.57	0.71	0.57	0.64	0.64	0.58	0.62	0.56	0.60	0.68	0.60	0.67	0.55	0.58	0.64	0.57	0.53	0.67	0.69	0.56	0.59	0.64	0.64	0.59	0.59	0.63	0.59	0.59	0.59	0.58	0.60	0.63	0.62	0.56	0.62	0.57	0.63	0.62	0.66	0.63	0.66	0.67	1.00	0.66	0.57	0.65	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
MET	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	1.5	RT-qPCR	Western US	C57BL/6 mice	–5.1	7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
MET	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	2.7	RT-qPCR	Western US	C57BL/6 mice	–5.1	7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
E2F1	1869	MET	4233	proximal_filtered	22955619	TRANSFAC
FOXP2	93986	MET	4233	Repression	17426099	TRUSST
SP1	6667	MET	4233	Unknown	8188699	TRUSST
PAX3	5077	MET	4233	Unknown	10426567	TRUSST
HIF1A	3091	MET	4233	Unknown	10601637	TRUSST
TP53	7157	MET	4233	Activation	8288055	TRUSST
SMAD7	4092	MET	4233	Activation	17300785	TRUSST
MITF	4286	MET	4233	Activation	7568086	TRUSST
PAX6	5080	MET	4233	Unknown	23530236	TRUSST
PAX5	5079	MET	4233	Unknown	10567574	TRUSST
YBX1	4904	MET	4233	Activation	8288055	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT000185	hsa-miR-206	Homo sapiens	MET	4233	Homo sapiens	Western blot	Functional MTI	19620785
MIRT000185	hsa-miR-206	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	19710019
MIRT000185	hsa-miR-206	Homo sapiens	MET	4233	Homo sapiens	FACS//Flow//Immunohistochemistry//qRT-PCR//Western blot	Functional MTI	26186594
MIRT000185	hsa-miR-206	Homo sapiens	MET	4233	Homo sapiens	qRT-PCR//ChIP//Luciferase reporter assay//Western blot//Northern blot	Functional MTI	20388878
MIRT000758	hsa-miR-34b-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	19461653
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	ELISA//Luciferase reporter assay//qRT-PCR	Functional MTI	24983493
MIRT000757	hsa-miR-34c-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	19461653
MIRT000757	hsa-miR-34c-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	20198305
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Flow//Immunofluorescence//In situ hybridization//qRT-PCR//Western blot	Functional MTI	26313360
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	qRT-PCR//Western blot	Functional MTI	19006648
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	19773441
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	qRT-PCR	Functional MTI (Weak)	21240262
MIRT000757	hsa-miR-34c-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	23922103
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Immunofluorescence//qRT-PCR//Western blot	Functional MTI	23970470
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Flow//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27513895
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	22159222
MIRT000757	hsa-miR-34c-5p	Homo sapiens	MET	4233	Homo sapiens	Microarray//Western blot//RTPCR	Functional MTI	20924086
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot//Northern blot	Functional MTI	19029026
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Immunohistochemistry//qRT-PCR//Western blot	Functional MTI	26238271
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	19461653
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	18834857
MIRT000757	hsa-miR-34c-5p	Homo sapiens	MET	4233	Homo sapiens	Next Generation Sequencing (NGS)//qRT-PCR//Western blot	Functional MTI	26795575
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	22457788
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	Immunoblot//qRT-PCR	Functional MTI (Weak)	28250026
MIRT000757	hsa-miR-34c-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	22419847
MIRT000759	hsa-miR-34a-5p	Homo sapiens	MET	4233	Homo sapiens	qRT-PCR//Western blot	Functional MTI	20309880
MIRT001357	hsa-miR-1-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	18818206
MIRT001357	hsa-miR-1-3p	Homo sapiens	MET	4233	Homo sapiens	Microarray	Functional MTI (Weak)	18668037
MIRT001357	hsa-miR-1-3p	Homo sapiens	MET	4233	Homo sapiens	Microarray//qRT-PCR//Western blot	Functional MTI	25874496
MIRT001357	hsa-miR-1-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27247259
MIRT001357	hsa-miR-1-3p	Homo sapiens	MET	4233	Homo sapiens	pSILAC//Proteomics	Functional MTI (Weak)	18668040
MIRT001357	hsa-miR-1-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	19710019
MIRT001357	hsa-miR-1-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	18593903
MIRT001357	hsa-miR-1-3p	Homo sapiens	MET	4233	Homo sapiens	qRT-PCR	Functional MTI (Weak)	21169019
MIRT001969	hsa-miR-199a-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	25839163
MIRT001969	hsa-miR-199a-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26051997
MIRT001969	hsa-miR-199a-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	18456660
MIRT001969	hsa-miR-199a-3p	Homo sapiens	MET	4233	Homo sapiens	Immunofluorescence//Microarray//QRTPCRWestern blot	Functional MTI	24810336
MIRT004292	hsa-miR-23b-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR	Functional MTI	19490101
MIRT004292	hsa-miR-23b-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	28077801
MIRT004292	hsa-miR-23b-3p	Homo sapiens	MET	4233	Homo sapiens	qRT-PCR//Luciferase reporter assay//Western blot	Functional MTI	25405368
MIRT004825	hsa-miR-34b-3p	Homo sapiens	MET	4233	Homo sapiens	Microarray//Western blot//RTPCR	Functional MTI	20924086
MIRT005024	hsa-miR-562	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Non-Functional MTI	19789318
MIRT005167	hsa-miR-30a-5p	Homo sapiens	MET	4233	Homo sapiens	pSILAC//Proteomics;Other	Functional MTI (Weak)	18668040
MIRT005458	hsa-miR-340-5p	Homo sapiens	MET	4233	Homo sapiens	Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	21692045
MIRT004825	hsa-miR-34b-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	22419847
MIRT006346	hsa-miR-449a	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western Blot//qRT-PCR	Functional MTI	23734217
MIRT006346	hsa-miR-449a	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	21418558
MIRT006351	hsa-miR-449b-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	21418558
MIRT006346	hsa-miR-449a	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26471185
MIRT006778	hsa-miR-198	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	21658389
MIRT007137	hsa-miR-130a-3p	Homo sapiens	MET	4233	Homo sapiens	qRT-PCR	Functional MTI (Weak)	23418453
MIRT016691	hsa-miR-133b	Homo sapiens	MET	4233	Homo sapiens	Western blot	Functional MTI	24391788
MIRT016691	hsa-miR-133b	Homo sapiens	MET	4233	Homo sapiens	Reporter assay	Functional MTI	20505319
MIRT035528	hsa-miR-31-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	23553486
MIRT035528	hsa-miR-31-5p	Homo sapiens	MET	4233	Homo sapiens	Immunoblot//Immunohistochemistry//Luciferase reporter assay//qRT-PCR	Functional MTI	22948084
MIRT035528	hsa-miR-31-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	23552883
MIRT035879	hsa-miR-1303	Homo sapiens	MET	4233	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT044529	hsa-miR-320a	Homo sapiens	MET	4233	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT053225	hsa-miR-137	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23151846
MIRT053148	hsa-miR-27a-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23650389
MIRT054232	hsa-miR-410-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	22750473
MIRT054388	hsa-miR-148a-3p	Homo sapiens	MET	4233	Homo sapiens	Immunoblot//Immunofluorescence//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	24013226
MIRT319319	hsa-miR-449c-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26141986
MIRT437442	hsa-miR-409-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23820886
MIRT437858	hsa-miR-101-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	23618864
MIRT438343	hsa-miR-144-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26250785
MIRT438343	hsa-miR-144-3p	Homo sapiens	MET	4233	Homo sapiens	ChIP-seq//Luciferase reporter assay//Microarray//qRT-PCR//Western blot	Functional MTI	25927670
MIRT438442	hsa-miR-7515	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23087254
MIRT440251	hsa-miR-218-5p	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23212916
MIRT732083	hsa-miR-139-5p	Homo sapiens	MET	4233	Homo sapiens	Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26497851
MIRT731338	hsa-miR-433-3p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	26844702
MIRT732479	hsa-miR-27b-3p	Homo sapiens	MET	4233	Homo sapiens	qRT-PCR//Luciferase reporter assay//Western blot	Functional MTI	25405368
MIRT733070	hsa-miR-34a-3p	Homo sapiens	MET	4233	Homo sapiens	Western blot	Functional MTI	27364974
MIRT734958	hsa-miR-1-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay	Functional MTI	27169691
MIRT735298	hsa-miR-144-5p	Homo sapiens	MET	4233	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	25961751
MIRT790064	hsa-miR-1257	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	28735896
MIRT790069	hsa-miR-1262	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	28735896
MIRT790503	hsa-miR-4506	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	28735896
MIRT790393	hsa-miR-425-5p	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	28735896
MIRT790571	hsa-miR-4701-3p	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	28735896
MIRT790733	hsa-miR-545-5p	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	28735896
MIRT790905	hsa-miR-6736-5p	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	28735896
MIRT791134	hsa-miR-802	Homo sapiens	MET	4233	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	28735896

Gene Ontology

ID	GO ID	GO Term	GO Type
4233	GO:0008283	cell proliferation	GOTERM_BP_DIRECT
4233	GO:0050918	positive chemotaxis	GOTERM_BP_DIRECT
4233	GO:0009925	basal plasma membrane	GOTERM_CC_DIRECT
4233	GO:0016021	integral component of membrane	GOTERM_CC_DIRECT
4233	GO:0001886	endothelial cell morphogenesis	GOTERM_BP_DIRECT
4233	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GOTERM_BP_DIRECT
4233	GO:0004672	protein kinase activity	GOTERM_MF_DIRECT
4233	GO:0004714	protein tyrosine kinase activity	GOTERM_MF_DIRECT
4233	GO:0019903	phosphatase binding	GOTERM_MF_DIRECT
4233	GO:0005008	olfactory receptor activity	GOTERM_MF_DIRECT
4233	GO:0007166	cell surface receptor signaling pathway	GOTERM_BP_DIRECT
4233	GO:0010507	negative regulation of autophagy	GOTERM_BP_DIRECT
4233	GO:0071526	semaphorin-plexin signaling pathway	GOTERM_BP_DIRECT
4233	GO:2001028	positive regulation of endothelial cell chemotaxis	GOTERM_BP_DIRECT
4233	GO:0004713	protein serine/threonine/tyrosine kinase activity	GOTERM_MF_DIRECT
4233	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
4233	GO:0007165	signal transduction	GOTERM_BP_DIRECT
4233	GO:0005576	extracellular region	GOTERM_CC_DIRECT
4233	GO:0048012	hepatocyte growth factor receptor signaling pathway	GOTERM_BP_DIRECT
4233	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	GOTERM_BP_DIRECT
4233	GO:0048754	branching morphogenesis of an epithelial tube	GOTERM_BP_DIRECT
4233	GO:0005887	integral component of plasma membrane	GOTERM_CC_DIRECT
4233	GO:0005515	protein binding	GOTERM_MF_DIRECT
4233	GO:0005524	ATP binding	GOTERM_MF_DIRECT
4233	GO:0017154	Wnt-protein binding	GOTERM_MF_DIRECT
4233	GO:0009986	cell surface	GOTERM_CC_DIRECT
4233	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
4233	GO:0018108	peptidyl-tyrosine phosphorylation	GOTERM_BP_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
4233	hsa04014	Ras signaling pathway
4233	hsa04015	Rap1 signaling pathway
4233	hsa04151	PI3K-Akt signaling pathway
4233	hsa04360	Axon guidance
4233	hsa04520	Adherens junction
4233	hsa04510	Focal adhesion
4233	hsa05100	Bacterial invasion of epithelial cells
4233	hsa05120	Epithelial cell signaling in Helicobacter pylori infection
4233	hsa05202	Transcriptional misregulation in cancer
4233	hsa05200	Pathways in cancer
4233	hsa05144	Malaria
4233	hsa05206	MicroRNAs in cancer
4233	hsa05218	Melanoma
4233	hsa05205	Proteoglycans in cancer
4233	hsa05211	Renal cell carcinoma
4233	hsa05230	Central carbon metabolism in cancer

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
MET	4233	Benign neoplasm of stomach	C0153943	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Malignant Neoplasms	C0006826	Neoplastic Process	0.4	0.405	0.793	group
MET	4233	Carcinoma in situ of stomach	C0154060	Neoplastic Process	0.31	0.405	0.793	disease
MET	4233	Stomach Carcinoma	C0699791	Neoplastic Process	0.4	0.405	0.793	disease
MET	4233	Adenocarcinoma of large intestine	C1319315	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Neoplasm of uncertain or unknown behavior of stomach	C0496905	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Squamous cell carcinoma of the head and neck	C1168401	Neoplastic Process	0.37	0.405	0.793	disease
MET	4233	Stomach Neoplasms	C0038356	Neoplastic Process	0.56	0.405	0.793	group
MET	4233	Conventional (Clear Cell) Renal Cell Carcinoma	C0279702	Neoplastic Process	0.57	0.405	0.793	disease
MET	4233	Non-Small Cell Lung Carcinoma	C0007131	Neoplastic Process	0.6	0.405	0.793	disease
MET	4233	Papillary Renal Cell Carcinoma	C1306837	Neoplastic Process	0.8	0.405	0.793	disease
MET	4233	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.7	0.405	0.793	disease
MET	4233	Liver carcinoma	C2239176	Neoplastic Process	0.8	0.405	0.793	disease
MET	4233	Malignant neoplasm of aortic body and other paraganglia	C0438413	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Benign neoplasm of aortic body and other paraganglia	C0154045	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Benign neoplasm of adrenal gland	C0154040	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Malignant Adrenal Medulla Neoplasm	C0344456	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Liver Neoplasms, Experimental	C0023904	Experimental Model of Disease; Neoplastic Process	0.3	0.405	0.793	group
MET	4233	Neoplasm Invasiveness	C0027626	Pathologic Function	0.3	0.405	0.793	phenotype
MET	4233	Adenocarcinoma, Basal Cell	C0205641	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Anaplastic astrocytoma	C0334579	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Adenocarcinoma	C0001418	Neoplastic Process	0.4	0.405	0.793	group
MET	4233	Experimental Hepatoma	C0086404	Experimental Model of Disease; Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Subependymal Giant Cell Astrocytoma	C0205768	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Juvenile Pilocytic Astrocytoma	C0280783	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Chronic active hepatitis	C0520463	Disease or Syndrome	0.3	0.405	0.793	disease
MET	4233	Collecting Duct Carcinoma of the Kidney	C1266044	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Renal Cell Carcinoma	C0007134	Neoplastic Process	0.5	0.405	0.793	disease
MET	4233	Squamous cell carcinoma	C0007137	Neoplastic Process	0.4	0.405	0.793	disease
MET	4233	Hepatoma, Novikoff	C0019208	Experimental Model of Disease; Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Osteosarcoma	C0029463	Neoplastic Process	0.4	0.405	0.793	disease
MET	4233	Giant Cell Glioblastoma	C0334588	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Acute Myeloid Leukemia, M1	C0026998	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Carcinoma, Cribriform	C0205643	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Cryptogenic Chronic Hepatitis	C0524611	Disease or Syndrome	0.3	0.405	0.793	disease
MET	4233	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.4	0.405	0.793	disease
MET	4233	Glioblastoma Multiforme	C1621958	Neoplastic Process	0.37	0.405	0.793	disease
MET	4233	Hepatoma, Morris	C0019207	Experimental Model of Disease; Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Lung Neoplasms	C0024121	Neoplastic Process	0.4	0.405	0.793	group
MET	4233	Neoplasm Metastasis	C0027627	Neoplastic Process	0.4	0.405	0.793	phenotype
MET	4233	Adenocarcinoma, Oxyphilic	C0205642	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Carcinoma, Granular Cell	C0205644	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Protoplasmic astrocytoma	C0334580	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Hepatitis, Chronic	C0019189	Disease or Syndrome	0.3	0.405	0.793	disease
MET	4233	Carcinoma	C0007097	Neoplastic Process	0.41	0.405	0.793	group
MET	4233	Adenocarcinoma, Tubular	C0205645	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Pilocytic Astrocytoma	C0334583	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	ovarian neoplasm	C0919267	Neoplastic Process	0.31	0.405	0.793	disease
MET	4233	Malignant neoplasm of esophagus	C0546837	Neoplastic Process	0.34	0.405	0.793	disease
MET	4233	Esophageal Neoplasms	C0014859	Neoplastic Process	0.32	0.405	0.793	group
MET	4233	Osteofibrous Dysplasia	C1709353	Disease or Syndrome	0.41	0.405	0.793	disease
MET	4233	Glioblastoma	C0017636	Neoplastic Process	0.4	0.405	0.793	disease
MET	4233	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.32	0.405	0.793	disease
MET	4233	Sinusitis	C0037199	Disease or Syndrome	0.3	0.405	0.793	disease
MET	4233	Diffuse Astrocytoma	C0280785	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Malignant neoplasm of ovary	C1140680	Neoplastic Process	0.38	0.405	0.793	disease
MET	4233	Carcinomatosis	C0205699	Neoplastic Process	0.3	0.405	0.793	phenotype
MET	4233	Gemistocytic astrocytoma	C0334581	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Intracranial Astrocytoma	C0750936	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Acute Myeloid Leukemia (AML-M2)	C1879321	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Autistic Disorder	C0004352	Mental or Behavioral Dysfunction	0.6	0.405	0.793	group
MET	4233	Leukemia, Myelocytic, Acute	C0023467	Neoplastic Process	0.33	0.405	0.793	disease
MET	4233	Neuroblastoma	C0027819	Neoplastic Process	0.3	0.405	0.793	group
MET	4233	Prostatic Neoplasms	C0033578	Neoplastic Process	0.36	0.405	0.793	group
MET	4233	Malignant neoplasm of lung	C0242379	Neoplastic Process	0.4	0.405	0.793	disease
MET	4233	Chromophobe Renal Cell Carcinoma	C1266042	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Chronic Persistent Hepatitis	C0149519	Disease or Syndrome	0.3	0.405	0.793	disease
MET	4233	Undifferentiated carcinoma	C0205698	Neoplastic Process	0.3	0.405	0.793	phenotype
MET	4233	Childhood Cerebral Astrocytoma	C0338070	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Mixed oligoastrocytoma	C0547065	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Cerebral Astrocytoma	C0750935	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Grade I Astrocytoma	C1704230	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Astrocytoma	C0004114	Neoplastic Process	0.33	0.405	0.793	disease
MET	4233	Cognition Disorders	C0009241	Mental or Behavioral Dysfunction	0.3	0.405	0.793	group
MET	4233	Anaplastic carcinoma	C0205696	Neoplastic Process	0.31	0.405	0.793	disease
MET	4233	Carcinoma, Spindle-Cell	C0205697	Neoplastic Process	0.31	0.405	0.793	disease
MET	4233	Fibrillary Astrocytoma	C0334582	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Malignant mesothelioma	C0345967	Neoplastic Process	0.34	0.405	0.793	disease
MET	4233	Sarcomatoid Renal Cell Carcinoma	C1266043	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Copper-Overload Cirrhosis	C1876165	Disease or Syndrome	0.3	0.405	0.793	disease
MET	4233	DEAFNESS, AUTOSOMAL RECESSIVE 97	C4084709	Disease or Syndrome	0.6	0.405	0.793	disease
MET	4233	Intellectual Disability	C3714756	Mental or Behavioral Dysfunction	0.3	0.405	0.793	group
MET	4233	Malignant neoplasm of kidney	C0740457	Neoplastic Process	0.39	0.405	0.793	disease
MET	4233	Hereditary Papillary Renal Carcinoma	C0879257	Neoplastic Process	0.4	0.405	0.793	disease
MET	4233	Tibia, Bowing of, with Pseudarthrosis and Pectus Excavatum	C1836723	Disease or Syndrome	0.3	0.405	0.793	disease
MET	4233	Papillary renal cell carcinoma, familial	C2931899	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Childhood Hepatocellular Carcinoma	C0279606	Neoplastic Process	0.4	0.405	0.793	disease
MET	4233	OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO	C4085248	Finding	0.3	0.405	0.793	phenotype
MET	4233	Malignant neoplasm of liver	C0345904	Neoplastic Process	0.32	0.405	0.793	disease
MET	4233	Hepatoblastoma Caused By Somatic Mutation	C2676033	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Hepatoblastoma	C0206624	Neoplastic Process	0.3	0.405	0.793	disease
MET	4233	Type 1 Papillary Renal Cell Carcinoma	C1336839	Neoplastic Process	0.32	0.405	0.793	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
MET	4233	[Crizotinib]	CRIZOTINIB	CHEMBL601719	None
MET	4233	ABBV-399	None	None	None
MET	4233	ABT-700	ABT-700	CHEMBL3545419	inhibitor
MET	4233	ABT-700	ABT-700	CHEMBL3545419	None
MET	4233	ALECTINIB	ALECTINIB	CHEMBL1738797	inhibitor
MET	4233	Alvespimycin	ALVESPIMYCIN	CHEMBL383824	None
MET	4233	Afatinib	AFATINIB	CHEMBL1173655	None
MET	4233	Altiratinib	ALTIRATINIB	CHEMBL3545365	None
MET	4233	ALTIRATINIB	ALTIRATINIB	CHEMBL3545365	inhibitor
MET	4233	ALTIRATINIB	ALTIRATINIB	CHEMBL3545365	inhibitor
MET	4233	AMG-208	AMG-208	CHEMBL496102	inhibitor
MET	4233	AMG102	RILOTUMUMAB	CHEMBL1743063	None
MET	4233	AMG-337	AMG-337	CHEMBL3545212	inhibitor
MET	4233	AMG 337	AMG-337	CHEMBL3545212	None
MET	4233	AMG208	AMG-208	CHEMBL496102	inhibitor
MET	4233	AM7	AMOXICILLIN	CHEMBL1082	inhibitor
MET	4233	AMG 0001	None	None	None
MET	4233	AMG 208	AMG-208	CHEMBL496102	inhibitor
MET	4233	AMG-337	AMG-337	CHEMBL3545212	inhibitor
MET	4233	AMUVATINIB	AMUVATINIB	CHEMBL2103851	None
MET	4233	Amuvatinib	AMUVATINIB	CHEMBL2103851	None
MET	4233	AMUVATINIB	AMUVATINIB	CHEMBL2103851	inhibitor
MET	4233	AMUVATINIB	AMUVATINIB	CHEMBL2103851	inhibitor
MET	4233	AMUVATINIB	AMUVATINIB	CHEMBL2103851	inhibitor
MET	4233	ANTI-CMET	None	None	antibody
MET	4233	ANTI-EGFR MONOCLONAL ANTIBODY	None	None	None
MET	4233	ARQ 197	TIVANTINIB	CHEMBL2103882	inhibitor
MET	4233	ARRY-300	ARRY-300	CHEMBL3545359	inhibitor
MET	4233	ARQ-197	TIVANTINIB	CHEMBL2103882	None
MET	4233	ARQ 197	TIVANTINIB	CHEMBL2103882	inhibitor
MET	4233	ARQ 197	TIVANTINIB	CHEMBL2103882	inhibitor
MET	4233	ARGX-111	None	None	None
MET	4233	AZD9291	OSIMERTINIB	CHEMBL3353410	None
MET	4233	BEZ235	DACTOLISIB	CHEMBL1879463	None
MET	4233	Bevacizumab	BEVACIZUMAB	CHEMBL1201583	None
MET	4233	BMS-777607	BMS-777607	CHEMBL460702	inhibitor
MET	4233	BMS-777607	BMS-777607	CHEMBL460702	inhibitor
MET	4233	BMS-698769	BMS-698769	CHEMBL3545299	inhibitor
MET	4233	BMS-794833	BMS-794833	CHEMBL3545119	inhibitor
MET	4233	BMS-777607	BMS-777607	CHEMBL460702	None
MET	4233	BMS-777607	BMS-777607	CHEMBL460702	inhibitor
MET	4233	BMS-817378	BMS-817378	CHEMBL3545050	inhibitor
MET	4233	BMS777607	BMS-777607	CHEMBL460702	inhibitor
MET	4233	BPI-9016	BPI-9016	CHEMBL3545236	inhibitor
MET	4233	Cabozantinib	CABOZANTINIB	CHEMBL2105717	None
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	None
MET	4233	CABOZANTINIB S-MALATE	CABOZANTINIB S-MALATE	CHEMBL2103868	inhibitor
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	None
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	None
MET	4233	Cabozatinib	None	None	None
MET	4233	CABOZANTANIB	None	None	None
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	inhibitor
MET	4233	Cabozantinib	CABOZANTINIB	CHEMBL2105717	None
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	inhibitor
MET	4233	cabozantinib	CABOZANTINIB	CHEMBL2105717	None
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	inhibitor
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	inhibitor
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	inhibitor
MET	4233	CABOZANTINIB	CABOZANTINIB	CHEMBL2105717	None
MET	4233	Cabozantinib	CABOZANTINIB	CHEMBL2105717	None
MET	4233	Capecitabine	CAPECITABINE	CHEMBL1773	None
MET	4233	CETUXIMAB	CETUXIMAB	CHEMBL1201577	None
MET	4233	Carboplatin	CARBOPLATIN	CHEMBL1351	None
MET	4233	CAPMATINIB	CAPMATINIB	CHEMBL3188267	inhibitor
MET	4233	Capmatinib	CAPMATINIB	CHEMBL3188267	None
MET	4233	CAPMATINIB	CAPMATINIB	CHEMBL3188267	None
MET	4233	Cetuximab	CETUXIMAB	CHEMBL1201577	None
MET	4233	CAPMATINIB	CAPMATINIB	CHEMBL3188267	inhibitor
MET	4233	CO1686	ROCILETINIB	CHEMBL3545308	None
MET	4233	COMETRIQ	CABOZANTINIB	CHEMBL2105717	inhibitor
MET	4233	COMPOUND 16 [PMID: 18945615]	None	None	inhibitor
MET	4233	COMPOUND 27 [PMID: 21123062]	None	None	inhibitor
MET	4233	COMPOUND 1O [PMID: 24210504]	None	None	inhibitor
MET	4233	COMPOUND R-16 [PMID: 21967808]	None	None	inhibitor
MET	4233	Crizotinib	CRIZOTINIB	CHEMBL601719	None
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	inhibitor
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	inhibitor
MET	4233	Crizotinib	CRIZOTINIB	CHEMBL601719	None
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	inhibitor
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	inhibitor
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	None
MET	4233	CRENOLANIB	CRENOLANIB	CHEMBL2105728	inhibitor
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	None
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	None
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	inhibitor
MET	4233	CRIZOTINIB	CRIZOTINIB	CHEMBL601719	None
MET	4233	Crizotinib	CRIZOTINIB	CHEMBL601719	None
MET	4233	Dasatinib	DASATINIB	CHEMBL1421	None
MET	4233	EMD1214063	Tepotinib	CHEMBL3402762	inhibitor
MET	4233	Emibetuzumab	EMIBETUZUMAB	CHEMBL3301578	None
MET	4233	EMD 1214063	Tepotinib	CHEMBL3402762	None
MET	4233	EMD 1204831	EMD-1204831	CHEMBL3545053	None
MET	4233	EMD-1204831	EMD-1204831	CHEMBL3545053	inhibitor
MET	4233	EMIBETUZUMAB	EMIBETUZUMAB	CHEMBL3301578	antibody
MET	4233	ENSARTINIB	None	None	inhibitor
MET	4233	Erlotinib	ERLOTINIB	CHEMBL553	None
MET	4233	FF-284	None	None	None
MET	4233	Fluorouracil	FLUOROURACIL	CHEMBL185	None
MET	4233	Ficlatuzumab	FICLATUZUMAB	CHEMBL1743018	None
MET	4233	FORETINIB	FORETINIB	CHEMBL1230609	inhibitor
MET	4233	FORETINIB	FORETINIB	CHEMBL1230609	None
MET	4233	FORETINIB	FORETINIB	CHEMBL1230609	inhibitor
MET	4233	Foretinib	FORETINIB	CHEMBL1230609	None
MET	4233	FORETINIB	FORETINIB	CHEMBL1230609	inhibitor
MET	4233	FORETINIB	FORETINIB	CHEMBL1230609	inhibitor
MET	4233	GE-137	None	None	None
MET	4233	Ganetespib	GANETESPIB	CHEMBL2103879	None
MET	4233	Gefitinib	GEFITINIB	CHEMBL939	None
MET	4233	GEFITINIB	GEFITINIB	CHEMBL939	None
MET	4233	GLESATINIB	CLOFIBRATE	CHEMBL565	inhibitor
MET	4233	GOLVATINIB	GOLVATINIB	CHEMBL3039525	inhibitor
MET	4233	Golvatinib	GOLVATINIB	CHEMBL3039525	None
MET	4233	GOLVATINIB	GOLVATINIB	CHEMBL3039525	inhibitor
MET	4233	GSK1363089	FORETINIB	CHEMBL1230609	inhibitor
MET	4233	HEPATOCYTE GROWTH FACTOR	None	None	None
MET	4233	Imatinib	IMATINIB	CHEMBL941	None
MET	4233	INCB028060	CAPMATINIB	CHEMBL3188267	None
MET	4233	INC280	CAPMATINIB	CHEMBL3188267	None
MET	4233	INCB28060	CAPMATINIB	CHEMBL3188267	inhibitor
MET	4233	INCB028060	CAPMATINIB	CHEMBL3188267	inhibitor
MET	4233	INC280	CAPMATINIB	CHEMBL3188267	inhibitor
MET	4233	JNJ 38877605	JNJ-38877605	CHEMBL2133806	None
MET	4233	KRC-00715	None	None	None
MET	4233	KTN0073-IgG1	None	None	None
MET	4233	KRC-00509	None	None	None
MET	4233	Lapatinib	LAPATINIB	CHEMBL554	None
MET	4233	Lapatinib	LAPATINIB	CHEMBL554	None
MET	4233	Leucovorin	LEUCOVORIN	CHEMBL1679	None
MET	4233	JNJ38877605	JNJ-38877605	CHEMBL2133806	inhibitor
MET	4233	JNJ-61186372	None	None	None
MET	4233	JNJ-38877605	JNJ-38877605	CHEMBL2133806	inhibitor
MET	4233	KTN0073-IgG2	None	None	None
MET	4233	JNJ38877605	JNJ-38877605	CHEMBL2133806	inhibitor
MET	4233	K252a	K-252A	CHEMBL281948	None
MET	4233	LY2801653	MERESTINIB	CHEMBL3545307	None
MET	4233	LY2875358	LY-2875358	CHEMBL2109517	antibody
MET	4233	LY2875358	LY-2875358	CHEMBL2109517	antibody
MET	4233	M-COPA	None	None	None
MET	4233	MERESTINIB	MERESTINIB	CHEMBL3545307	inhibitor
MET	4233	MET INHIBITION, ERBB3 INHIBITION	None	None	None
MET	4233	METMAB	ONARTUZUMAB	CHEMBL1743051	None
MET	4233	MGCD265	MGCD-265	CHEMBL254760	inhibitor
MET	4233	MGCD265	MGCD-265	CHEMBL254760	inhibitor
MET	4233	mFOLFOX6	None	None	None
MET	4233	MGCD-265	MGCD-265	CHEMBL254760	inhibitor
MET	4233	MGCD265	MGCD-265	CHEMBL254760	None
MET	4233	METMAB	ONARTUZUMAB	CHEMBL1743051	antibody
MET	4233	MGCD265	MGCD-265	CHEMBL254760	inhibitor
MET	4233	MGCD265	MGCD-265	CHEMBL254760	None
MET	4233	MK-2461	MK-2461	CHEMBL1822792	inhibitor
MET	4233	MK-2461	MK-2461	CHEMBL1822792	inhibitor
MET	4233	MK-8033	MK-8033	CHEMBL2323775	inhibitor
MET	4233	MK2461	MK-2461	CHEMBL1822792	inhibitor
MET	4233	MK-2461	MK-2461	CHEMBL1822792	inhibitor
MET	4233	MK-8033	MK-8033	CHEMBL2323775	inhibitor
MET	4233	MP470	AMUVATINIB	CHEMBL2103851	inhibitor
MET	4233	MTERON-F1	RILONACEPT	CHEMBL1201830	stimulator
MET	4233	MSC2156119J	Tepotinib	CHEMBL3402762	None
MET	4233	None	None	None	None
MET	4233	None	None	None	None
MET	4233	NPS-1034	None	None	None
MET	4233	Olaparib	OLAPARIB	CHEMBL521686	None
MET	4233	ONARTUZUMAB	ONARTUZUMAB	CHEMBL1743051	antibody
MET	4233	ONARTUZUMAB	ONARTUZUMAB	CHEMBL1743051	antibody
MET	4233	Onartuzumab	ONARTUZUMAB	CHEMBL1743051	None
MET	4233	Osimertinib	OSIMERTINIB	CHEMBL3353410	None
MET	4233	ONARTUZUMAB	ONARTUZUMAB	CHEMBL1743051	None
MET	4233	ONARTUZUMAB	ONARTUZUMAB	CHEMBL1743051	antibody
MET	4233	ONARTUZUMAB	ONARTUZUMAB	CHEMBL1743051	antagonist
MET	4233	ONARTUZUMAB	ONARTUZUMAB	CHEMBL1743051	inhibitor
MET	4233	Oxaliplatin	OXALIPLATIN	CHEMBL414804	None
MET	4233	Paclitaxel	PACLITAXEL	CHEMBL428647	None
MET	4233	Panitumumab	PANITUMUMAB	CHEMBL1201827	None
MET	4233	Panitumumab	PANITUMUMAB	CHEMBL1201827	None
MET	4233	PF-4217903	PF-04217903	CHEMBL2001019	inhibitor
MET	4233	PF-04217903	PF-04217903	CHEMBL2001019	inhibitor
MET	4233	PF-04217903	PF-04217903	CHEMBL2001019	inhibitor
MET	4233	PHA-665752	PHA-665752	CHEMBL450786	inhibitor
MET	4233	PF-4217903	PF-04217903	CHEMBL2001019	inhibitor
MET	4233	PHA-665752	PHA-665752	CHEMBL450786	None
MET	4233	PP-121	CHEMBL1081312	CHEMBL1081312	None
MET	4233	Ponatinib	PONATINIB	CHEMBL1171837	None
MET	4233	Radiotherapy	None	None	None
MET	4233	Rociletinib	ROCILETINIB	CHEMBL3545308	None
MET	4233	Savolitinib	Savolitinib	CHEMBL3545336	inhibitor
MET	4233	Savolitinib	Savolitinib	CHEMBL3545336	None
MET	4233	Rucaparib	RUCAPARIB	CHEMBL1173055	None
MET	4233	S-49076	None	None	None
MET	4233	SAR-125844	SAR-125844	CHEMBL3545325	inhibitor
MET	4233	SAR125844	SAR-125844	CHEMBL3545325	None
MET	4233	SAVOLITINIB	Savolitinib	CHEMBL3545336	None
MET	4233	Selumetinib	SELUMETINIB	CHEMBL1614701	None
MET	4233	SGX523	SGX-523	CHEMBL1236107	inhibitor
MET	4233	SGX523	SGX-523	CHEMBL1236107	None
MET	4233	SGX-523	SGX-523	CHEMBL1236107	inhibitor
MET	4233	SGX-523	SGX-523	CHEMBL1236107	inhibitor
MET	4233	SELUMETINIB, TRAMETINIB	None	None	None
MET	4233	SGX523	SGX-523	CHEMBL1236107	None
MET	4233	Sorafenib	SORAFENIB	CHEMBL1336	None
MET	4233	SU11274	PYRAZINAMIDE	CHEMBL614	inhibitor
MET	4233	SU11274	PYRAZINAMIDE	CHEMBL614	None
MET	4233	TAE226	CHEMBL458997	CHEMBL458997	None
MET	4233	SYM015	None	None	None
MET	4233	TAK-701	None	None	antibody
MET	4233	TANESPIMYCIN	TANESPIMYCIN	CHEMBL109480	inhibitor
MET	4233	Tepotinib	Tepotinib	CHEMBL3402762	inhibitor
MET	4233	TEPOTINIB	Tepotinib	CHEMBL3402762	inhibitor
MET	4233	TAS-115	TAS-115	CHEMBL3545144	inhibitor
MET	4233	TAS-115	TAS-115	CHEMBL3545144	None
MET	4233	TIVANTINIB	TIVANTINIB	CHEMBL2103882	inhibitor
MET	4233	TIVANTINIB	TIVANTINIB	CHEMBL2103882	inhibitor
MET	4233	TIVANTINIB	TIVANTINIB	CHEMBL2103882	inhibitor
MET	4233	TIVANTINIB	TIVANTINIB	CHEMBL2103882	inhibitor
MET	4233	TIVANTINIB	TIVANTINIB	CHEMBL2103882	inhibitor
MET	4233	Trametinib	TRAMETINIB	CHEMBL2103875	None
MET	4233	Trastuzumab	TRASTUZUMAB	CHEMBL1201585	None
MET	4233	Trastuzumab	TRASTUZUMAB	CHEMBL1201585	None
MET	4233	Veliparib	VELIPARIB	CHEMBL506871	None
MET	4233	Vemurafenib	VEMURAFENIB	CHEMBL1229517	None
MET	4233	VEMURAFENIB	VEMURAFENIB	CHEMBL1229517	None
MET	4233	XL880	FORETINIB	CHEMBL1230609	inhibitor
MET	4233	XL880	FORETINIB	CHEMBL1230609	None
MET	4233	XL147	PILARALISIB (CHEMBL3218575)	CHEMBL3218575	None