ALTITUDEOMICSDB

Protein tyrosine kinase 2

AltitudeomicsDB

Protein Official symbol	PTK2
Aliases	PTK2 FAK FAK1
Chromosomal Location	8
Length	1052
Uniprot ID	Q05397
EC number	2.7.10.2
Protein family Information(Pfam)	PF00373;PF18038;PF03623;PF07714;
PDB id	1K04;1K05;1MP8;1OW6;1OW7;1OW8;2ETM;2IJM;3B71;3BZ3;3PXK;3S9O;4EBV;4EBW;4GU6;4GU9;4I4E;4I4F;4K8A;4K9Y;4KAB;4KAO;4NY0;4Q9S;6I8Z;6LES;
InterPro ID	IPR019749;IPR041390;IPR041784;IPR014352;IPR035963;IPR019748;IPR000299;IPR036137;IPR005189;IPR011009;IPR011993;IPR000719;IPR017441;IPR001245;IPR008266;IPR020635;IPR029071;
dbSNP	None

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
PTK2	PXN	0.997
SHC1	GRB2	0.997
PXN	VCL	0.997
CDC42	WAS	0.997
CXCR4	CXCL12	0.996
CDC42	WASL	0.995
SOS1	GRB2	0.995
BCAR1	PXN	0.993
BCAR1	CRK	0.992
RAPGEF1	CRK	0.992
VEGFA	HGF	0.992
CRK	DOCK1	0.991
BCAR1	PTK2	0.99
CTTN	WASL	0.989
VEGFA	FN1	0.988
NCK1	WAS	0.988
PTPN11	MAPK3	0.987
RAPGEF1	CRKL	0.987
ITGB3	ITGAV	0.986
ITGB1	ITGA5	0.986
DCC	NTN1	0.986
TLN1	VCL	0.986
FN1	ITGA5	0.985
NCK1	WASL	0.985
RHOA	ARHGAP35	0.985
ZYX	VCL	0.984
PTK2	VCL	0.984
GRB2	MAPK3	0.984
CDC42	PTK2	0.983
FN1	VCL	0.983
FN1	PXN	0.983
BCAR1	DOCK1	0.983
CRK	PXN	0.983
CTTN	PTK2	0.982
ITGB1	FN1	0.982
PTPN11	PXN	0.982
HRAS	MAPK3	0.981
RHOA	VCL	0.981
SHC1	SOS1	0.981
VAV1	WAS	0.981
CDC42	PXN	0.981
ITGB1	ITGA3	0.981
ITGB1	ITGAV	0.981
GIT2	PXN	0.98
SOS1	PTPN11	0.98
RHOA	PXN	0.98
NCK1	CDC42	0.979
MAPK3	KRAS	0.979
BCAR1	VCL	0.979
HRAS	PTPN11	0.979
VAV1	CDC42	0.978
PTEN	PTK2	0.978
BCAR1	ZYX	0.977
VEGFA	RHOA	0.977
BCAR1	CRKL	0.977
TLN1	PXN	0.976
HRAS	GRB2	0.976
CDC42	CTTN	0.976
HRAS	SOS1	0.976
CTTN	PXN	0.976
ITGB3	ITGA3	0.975
WAS	RAC1	0.975
FN1	PTK2	0.975
ITGB1	VCL	0.974
ACTN4	VCL	0.974
ARHGAP35	CDC42	0.973
SOS1	KRAS	0.973
RHOA	PTK2	0.973
RHOA	MAPK3	0.972
PTPN11	KRAS	0.972
SHC1	MAPK3	0.971
GRB2	HGF	0.971
ITGB1	ITGA2	0.971
CDC42	DOCK1	0.971
PTK2	WASL	0.971
VEGFA	CDC42	0.971
ITGB3	ITGA2	0.971
GRB2	KRAS	0.971
SHC1	PTEN	0.97
ZYX	TLN1	0.97
FN1	ITGAV	0.97
FN1	MAPK3	0.97
VAV1	RHOA	0.97
RHOA	EZR	0.97
VAV1	RAC1	0.969
PECAM1	PTPN11	0.969
RAC1	WASL	0.969
RAC1	PXN	0.968
HRAS	HGF	0.968
ITGB3	TLN1	0.968
CDC42	FN1	0.968
KRAS	HGF	0.968
FN1	HGF	0.968
PTK2	PTPN11	0.968
RHOA	PTPN11	0.967
BCAR1	FN1	0.967
CXCR4	PTK2	0.967
BCAR1	RAPGEF1	0.967
PTK2	HGF	0.967
ARHGAP35	PTK2	0.967
PXN	MAPK3	0.967
DOCK1	PXN	0.966
FN1	ITGA2	0.965
PTK2	CRK	0.965
NCK1	PTK2	0.965
TLN1	ITGA5	0.965
HRAS	SHC1	0.965
SOS1	MAPK3	0.965
ITGB1	TLN1	0.963
VEGFA	PTK2	0.963
CDC42	CRK	0.963
RAPGEF1	PTK2	0.963
MAPK3	HGF	0.963
SHC1	HGF	0.962
ITGB3	FN1	0.962
GRB7	PTK2	0.962
PTK2	TLN1	0.962
RAC1	DOCK1	0.962
CDC42	GIT2	0.962
GIT2	PTK2	0.962
PTK2	ZYX	0.961
CXCL12	MAPK3	0.961
PXN	TNS1	0.96
GRB2	PTK2	0.96
EZR	PXN	0.96
ITGB1	PXN	0.96
ITGB3	ITGA5	0.959
PECAM1	ITGB3	0.959
BCAR1	CDC42	0.959
RHOA	DOCK1	0.958
VAV1	PTPN11	0.958
SHC1	PTK2	0.958
ITGB1	PTK2	0.958
MAPK3	VCL	0.958
HRAS	FN1	0.958
VCL	TNS1	0.957
GRB2	PTEN	0.957
TLN1	ACTN4	0.957
RHOA	BCAR1	0.957
CRKL	DOCK1	0.957
ARHGAP35	RAC1	0.956
NCK1	BCAR1	0.956
PECAM1	ITGAV	0.956
RHOA	TNS1	0.956
SHC1	KRAS	0.956
CRKL	PXN	0.956
VEGFA	ITGB1	0.955
VAV1	DOCK1	0.955
ITGB3	VCL	0.955
CTTN	RAC1	0.955
NCK1	PXN	0.955
BCAR1	PTPN11	0.955
ITGB1	HGF	0.954
DOCK1	WASL	0.954
RHOA	GRB2	0.954
RHOA	CASP3	0.954
SOS1	CDC42	0.954
EZR	PTK2	0.953
FN1	KRAS	0.953
ITGB7	ITGAV	0.953
ITGB7	ITGA3	0.953
RHOA	CRK	0.953
BCAR1	TNS1	0.952
PTK2	TNS1	0.952
HRAS	PTK2	0.952
ZYX	ACTN4	0.951
PTK2	CASP3	0.951
NCK1	RAC1	0.951
VEGFA	PXN	0.951
FN1	TLN1	0.95
CDC42	ITGB1	0.95
PTK2	DOCK1	0.95
RAC1	CRK	0.949
VAV1	SOS1	0.949
TLN1	ITGAV	0.949
PTK2	ACTN4	0.949
SOS1	RAC1	0.949
CDC42	NTN1	0.949
VEGFA	GRB2	0.948
PTK2	KRAS	0.948
RAC1	PTK2	0.948
PXN	ACTN4	0.948
RHOA	TLN1	0.948
RHOA	ZYX	0.947
VEGFA	SHC1	0.947
BCAR1	TLN1	0.947
RAC1	FN1	0.946
BCAR1	TRIP6	0.946
RHOA	ACTN4	0.946
BCAR1	RAC1	0.946
FN1	CRK	0.945
CXCR4	CDC42	0.945
RHOA	SOS1	0.945
RAC1	MAPK3	0.945
CDC42	CXCL12	0.945
DCC	DOCK1	0.945
PTK2	ITGA3	0.945
RHOA	NTN1	0.945
CDC42	HGF	0.945
ITGB3	PXN	0.944
SHC1	RHOA	0.944
EZR	RAC1	0.944
VEGFA	PTPN11	0.944
ITGB3	PTK2	0.944
BCAR1	ITGB1	0.944
VEGFA	ITGAV	0.943
PTK2	NTN1	0.943
EZR	ACTN4	0.943
VAV1	HRAS	0.942
PXN	ITGAV	0.942
RHOA	ITGB1	0.941
RAC1	GIT2	0.941
NCK1	GIT2	0.941
DCC	PTK2	0.941
ITGB1	ACTN4	0.941
ITGB1	CASP3	0.94
ZYX	TNS1	0.94
PTK2	ITGAV	0.94
PECAM1	PTK2	0.94
HRAS	VCL	0.94
PTK2	TRIP6	0.94
CRK	TRIP6	0.94
VEGFA	BCAR1	0.939
ZYX	PXN	0.939
ITGB3	RHOA	0.939
PTPN11	HGF	0.939
VEGFA	ITGB3	0.939
VAV1	CXCR4	0.939
WAS	PTK2	0.939
PTK2	ITGA5	0.939
CXCL12	PTK2	0.939
DOCK1	NTN1	0.938
NCK1	SOS1	0.938
GRB2	PTPN11	0.938
PECAM1	PXN	0.938
VAV1	PTK2	0.938
HRAS	CXCL12	0.938
ASAP1	PTK2	0.937
VAV1	CXCL12	0.937
ITGB3	CDC42	0.937
SOS1	PTK2	0.937
CRKL	PTK2	0.937
ARHGAP35	PTPN11	0.936
NCK1	DOCK1	0.935
CRK	HGF	0.935
ITGA2	ITGA3	0.935
FN1	ACTN4	0.935
VAV1	FCER1G	0.935
KRAS	VCL	0.935
PTK2	ITGA2	0.935
PTK2	ITGB7	0.935
VAV1	NCK1	0.935
ITGA2	ITGB7	0.934
TLN1	TNS1	0.934
RHOA	RAPGEF1	0.933
PTK2	FCER1G	0.933
SOS1	PTEN	0.933
RAC1	NTN1	0.933
PTK2	MAPK3	0.932
CRKL	VCL	0.932
SHC1	PTPN11	0.932
ITGA5	ITGB7	0.932
NCK1	HRAS	0.932
PXN	ITGB7	0.931
DCC	CDC42	0.93
ITGAV	ITGA3	0.93
PTPN11	CRK	0.93
ITGB1	PTEN	0.93
FN1	ITGB7	0.929
ITGA2	ITGAV	0.929
BCAR1	ITGAV	0.929
BCAR1	HGF	0.929
CXCL12	PXN	0.929
CXCL12	EZR	0.928
PXN	TRIP6	0.928
RAPGEF1	PTPN11	0.928
HRAS	ARHGAP35	0.928
ITGB1	GRB2	0.928
CXCR4	PXN	0.928
CTTN	GIT2	0.928
WASL	VCL	0.928
BCAR1	DCC	0.928
ITGB3	MAPK3	0.928
VEGFA	SOS1	0.928
RHOA	CDC42	0.928
CDC42	ITGAV	0.926
EZR	TLN1	0.926
CRKL	PTPN11	0.926
BCAR1	ACTN4	0.926
MAPK3	ITGAV	0.926
CXCL12	RAC1	0.925
ITGB1	EZR	0.925
BCAR1	NTN1	0.925
GRB2	CRKL	0.925
ARHGAP35	KRAS	0.925
VEGFA	NCK1	0.925
ITGB1	ZYX	0.924
RHOA	KRAS	0.924
HRAS	RHOA	0.924
ITGB1	TNS1	0.924
RHOA	ITGAV	0.923
RHOA	DCC	0.923
CRKL	HGF	0.923
RAC1	CRKL	0.923
VEGFA	ACTN4	0.923
RAC1	HGF	0.923
SHC1	ITGB1	0.922
ITGB3	HRAS	0.922
CXCR4	RAC1	0.922
GRB2	FCER1G	0.922
ASAP1	RHOA	0.922
ITGB3	BCAR1	0.922
CXCR4	PTPN11	0.921
ITGB1	CTTN	0.921
DCC	RAC1	0.921
NCK1	NTN1	0.921
VEGFA	ITGA3	0.921
WAS	VCL	0.92
VAV1	GRB2	0.92
VAV1	CRK	0.92
RAC1	TLN1	0.92
BCAR1	CXCL12	0.919
WASL	NTN1	0.919
CXCL12	PTPN11	0.919
TLN1	CRK	0.919
DCC	CASP3	0.919
CRKL	TLN1	0.918
CRK	ITGAV	0.917
WASL	HGF	0.917
ITGB3	KRAS	0.917
PECAM1	BCAR1	0.917
CRKL	TNS1	0.917
DCC	WASL	0.917
SHC1	FCER1G	0.917
HRAS	RAC1	0.917
SOS1	FN1	0.917
ITGA2	HGF	0.916
ITGB1	RAC1	0.916
RAC1	KRAS	0.916
BCAR1	CXCR4	0.916
RAC1	ACTN4	0.916
HRAS	TLN1	0.916
TLN1	MAPK3	0.916
CRKL	ZYX	0.916
PTPN11	NTN1	0.915
SOS1	HGF	0.915
ITGB3	CRK	0.915
ITGB3	SHC1	0.914
DCC	EZR	0.914
ITGB3	RAC1	0.913
RHOA	RAC1	0.913
ITGB1	CRKL	0.912
DCC	PTPN11	0.911
RAC1	ITGA5	0.91
PTPN11	FCER1G	0.91
CRKL	ACTN4	0.91
ACTN4	TNS1	0.91
NCK1	HGF	0.91
SHC1	TLN1	0.909
HGF	ITGA3	0.909
ASAP1	RAC1	0.908
RAC1	ITGAV	0.908
NCK1	DCC	0.908
ITGB3	ITGB1	0.908
ASAP1	HRAS	0.908
ITGB3	ITGB7	0.907
RHOA	ITGB7	0.907
CRKL	CRK	0.906
VEGFA	CXCL12	0.906
WAS	WASL	0.906
CDC42	RAC1	0.906
RAPGEF1	HGF	0.906
TLN1	KRAS	0.905
ITGB1	ITGB7	0.905
SOS1	TLN1	0.905
ITGB1	GIT2	0.904
SOS1	ITGB1	0.904
SOS1	FCER1G	0.904
ITGB3	SOS1	0.903
HRAS	KRAS	0.902
VEGFA	PECAM1	0.902
HRAS	PTEN	0.901
ACTN4	HGF	0.901

Gene Ontology Semantic Similarity

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#	5829 (PXN)	2885 (GRB2)	7414 (VCL)	7454 (WAS)	6387 (CXCL12)	8976 (WASL)	1398 (CRK)	3082 (HGF)	1793 (DOCK1)	5747 (PTK2)	2335 (FN1)	5595 (MAPK3)	1399 (CRKL)	3685 (ITGAV)	3678 (ITGA5)	9423 (NTN1)	2909 (ARHGAP35)	6654 (SOS1)	3675 (ITGA3)	5781 (PTPN11)	998 (CDC42)	3845 (KRAS)	7791 (ZYX)	387 (RHOA)	2017 (CTTN)	5879 (RAC1)	3673 (ITGA2)	5728 (PTEN)	7094 (TLN1)	7430 (EZR)	2889 (RAPGEF1)	6464 (SHC1)	9815 (GIT2)	7145 (TNS1)	3690 (ITGB3)	81 (ACTN4)	9564 (BCAR1)	3688 (ITGB1)	836 (CASP3)	7205 (TRIP6)	3265 (HRAS)	7852 (CXCR4)	2207 (FCER1G)	3695 (ITGB7)	4690 (NCK1)	1630 (DCC)	5175 (PECAM1)	7422 (VEGFA)	7409 (VAV1)	2886 (GRB7)	50807 (ASAP1)
5829 (PXN)	1.00	0.61	0.79	0.67	0.71	0.69	0.72	0.56	0.66	0.62	0.68	0.65	0.71	0.65	0.74	1.00	0.26	0.56	0.77	0.52	0.58	0.77	0.74	0.64	0.79	0.63	0.62	0.52	0.75	0.72	0.66	0.62	1.00	0.74	0.67	0.58	0.77	0.68	0.44	0.69	0.61	0.55	0.67	0.77	0.68	0.71	0.77	0.64	0.57	0.73	0.78
2885 (GRB2)	0.61	1.00	0.61	0.66	0.60	0.57	0.77	0.72	0.64	0.73	0.62	0.66	0.75	0.60	0.60	1.00	0.30	0.65	0.59	0.74	0.64	0.58	0.64	0.59	0.60	0.64	0.54	0.51	0.58	0.70	0.64	0.77	1.00	0.64	0.62	0.60	0.63	0.60	0.45	0.67	0.53	0.51	0.56	0.59	0.66	0.55	0.59	0.62	0.75	0.64	0.59
7414 (VCL)	0.79	0.61	1.00	0.69	0.70	0.72	0.72	0.58	0.67	0.62	0.68	0.63	0.76	0.66	0.73	1.00	0.27	0.59	0.76	0.54	0.60	0.76	0.73	0.65	0.84	0.64	0.64	0.54	0.75	0.78	0.67	0.63	1.00	0.73	0.68	0.64	0.76	0.75	0.48	0.70	0.63	0.64	0.67	0.78	0.71	0.71	0.76	0.65	0.59	0.73	0.84
7454 (WAS)	0.67	0.66	0.69	1.00	0.63	0.82	0.73	0.56	0.62	0.63	0.67	0.59	0.66	0.64	0.64	1.00	0.33	0.64	0.66	0.55	0.62	0.65	0.63	0.64	0.67	0.64	0.59	0.55	0.63	0.76	0.62	0.63	1.00	0.63	0.67	0.60	0.72	0.65	0.46	0.65	0.56	0.54	0.61	0.66	0.66	0.61	0.66	0.63	0.56	0.73	0.66
6387 (CXCL12)	0.71	0.60	0.70	0.63	1.00	0.62	0.69	0.53	0.58	0.53	0.72	0.56	0.65	0.67	0.68	1.00	0.24	0.51	0.69	0.51	0.55	0.67	0.64	0.58	0.70	0.57	0.58	0.49	0.72	0.69	0.58	0.65	1.00	0.64	0.68	0.61	0.67	0.70	0.41	0.66	0.55	0.52	0.61	0.79	0.68	0.62	0.67	0.67	0.52	0.65	0.69
8976 (WASL)	0.69	0.57	0.72	0.82	0.62	1.00	0.66	0.49	0.60	0.53	0.62	0.51	0.64	0.61	0.63	1.00	0.38	0.63	0.68	0.44	0.51	0.66	0.61	0.53	0.70	0.54	0.55	0.45	0.62	0.74	0.60	0.58	1.00	0.61	0.63	0.58	0.66	0.65	0.37	0.60	0.49	0.50	0.58	0.68	0.64	0.57	0.66	0.60	0.51	0.64	0.68
1398 (CRK)	0.72	0.77	0.72	0.73	0.69	0.66	1.00	0.57	0.64	0.65	0.67	0.61	0.81	0.66	0.70	1.00	0.26	0.58	0.72	0.67	0.62	0.71	0.69	0.67	0.73	0.65	0.62	0.54	0.68	0.73	0.64	0.74	1.00	0.69	0.66	0.58	0.77	0.67	0.49	0.69	0.61	0.56	0.65	0.72	0.75	0.68	0.72	0.64	0.64	0.74	0.72
3082 (HGF)	0.56	0.72	0.58	0.56	0.53	0.49	0.57	1.00	0.61	0.75	0.58	0.68	0.56	0.55	0.50	1.00	0.24	0.63	0.53	0.58	0.60	0.50	0.48	0.47	0.54	0.60	0.48	0.47	0.53	0.62	0.61	0.59	1.00	0.48	0.59	0.49	0.50	0.57	0.54	0.50	0.45	0.45	0.50	0.52	0.56	0.46	0.52	0.66	0.71	0.55	0.51
1793 (DOCK1)	0.66	0.64	0.67	0.62	0.58	0.60	0.64	0.61	1.00	0.62	0.59	0.49	0.61	0.59	0.59	1.00	0.28	0.90	0.64	0.41	0.49	0.61	0.56	0.50	0.66	0.51	0.51	0.43	0.59	0.66	0.90	0.67	1.00	0.56	0.61	0.50	0.61	0.62	0.33	0.57	0.46	0.46	0.54	0.63	0.61	0.52	0.61	0.59	0.78	0.60	0.63
5747 (PTK2)	0.62	0.73	0.62	0.63	0.53	0.53	0.65	0.75	0.62	1.00	0.57	0.75	0.55	0.59	0.52	1.00	0.23	0.63	0.55	0.61	0.69	0.53	0.51	0.56	0.56	0.72	0.49	0.46	0.54	0.67	0.62	0.62	1.00	0.51	0.59	0.53	0.62	0.60	0.40	0.57	0.47	0.49	0.51	0.54	0.58	0.49	0.53	0.56	0.68	0.62	0.53
2335 (FN1)	0.68	0.62	0.68	0.67	0.72	0.62	0.67	0.58	0.59	0.57	1.00	0.61	0.66	0.68	0.65	1.00	0.27	0.55	0.70	0.55	0.61	0.65	0.63	0.61	0.67	0.63	0.68	0.58	0.72	0.70	0.59	0.66	1.00	0.63	0.72	0.62	0.66	0.72	0.47	0.65	0.62	0.54	0.63	0.72	0.66	0.62	0.66	0.72	0.55	0.69	0.66
5595 (MAPK3)	0.65	0.66	0.63	0.59	0.56	0.51	0.61	0.68	0.49	0.75	0.61	1.00	0.61	0.58	0.56	1.00	0.22	0.43	0.59	0.58	0.71	0.57	0.54	0.51	0.61	0.73	0.51	0.49	0.56	0.65	0.49	0.53	1.00	0.54	0.63	0.51	0.57	0.61	0.41	0.55	0.48	0.48	0.54	0.58	0.58	0.52	0.59	0.60	0.59	0.61	0.58
1399 (CRKL)	0.71	0.75	0.76	0.66	0.65	0.64	0.81	0.56	0.61	0.55	0.66	0.61	1.00	0.63	0.68	1.00	0.35	0.53	0.71	0.60	0.59	0.70	0.83	0.61	0.80	0.60	0.59	0.52	0.71	0.80	0.61	0.65	1.00	0.83	0.66	0.67	0.70	0.69	0.43	0.76	0.59	0.53	0.64	0.73	0.74	0.65	0.72	0.64	0.60	0.72	0.79
3685 (ITGAV)	0.65	0.60	0.66	0.64	0.67	0.61	0.66	0.55	0.59	0.59	0.68	0.58	0.63	1.00	0.63	1.00	0.25	0.55	0.68	0.57	0.59	0.63	0.62	0.62	0.65	0.62	0.63	0.55	0.67	0.67	0.59	0.62	1.00	0.62	0.85	0.60	0.67	0.79	0.49	0.63	0.57	0.68	0.65	0.70	0.63	0.67	0.64	0.65	0.55	0.66	0.64
3678 (ITGA5)	0.74	0.60	0.73	0.64	0.68	0.63	0.70	0.50	0.59	0.52	0.65	0.56	0.68	0.63	1.00	1.00	0.25	0.49	0.75	0.46	0.54	0.74	0.69	0.58	0.77	0.57	0.58	0.47	0.66	0.70	0.59	0.61	1.00	0.69	0.73	0.54	0.74	0.66	0.37	0.70	0.54	0.51	0.62	0.73	0.66	0.65	0.74	0.76	0.50	0.69	0.76
9423 (NTN1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.38	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
2909 (ARHGAP35)	0.26	0.30	0.27	0.33	0.24	0.38	0.26	0.24	0.28	0.23	0.27	0.22	0.35	0.25	0.25	0.38	1.00	0.41	0.26	0.20	0.23	0.27	0.39	0.24	0.27	0.24	0.27	0.20	0.25	0.32	0.28	0.33	0.38	0.39	0.25	0.46	0.26	0.26	0.22	0.35	0.25	0.21	0.24	0.26	0.27	0.24	0.26	0.28	0.34	0.38	0.26
6654 (SOS1)	0.56	0.65	0.59	0.64	0.51	0.63	0.58	0.63	0.90	0.63	0.55	0.43	0.53	0.55	0.49	1.00	0.41	1.00	0.52	0.38	0.45	0.49	0.45	0.44	0.54	0.46	0.46	0.40	0.51	0.61	0.84	0.67	1.00	0.45	0.57	0.46	0.49	0.57	0.34	0.49	0.41	0.43	0.47	0.51	0.56	0.42	0.49	0.56	0.74	0.51	0.50
3675 (ITGA3)	0.77	0.59	0.76	0.66	0.69	0.68	0.72	0.53	0.64	0.55	0.70	0.59	0.71	0.68	0.75	1.00	0.26	0.52	1.00	0.49	0.57	0.79	0.75	0.62	0.81	0.62	0.60	0.52	0.69	0.71	0.64	0.60	1.00	0.75	0.69	0.56	0.80	0.75	0.40	0.69	0.58	0.52	0.66	0.78	0.66	0.71	0.80	0.67	0.53	0.73	0.81
5781 (PTPN11)	0.52	0.74	0.54	0.55	0.51	0.44	0.67	0.58	0.41	0.61	0.55	0.58	0.60	0.57	0.46	1.00	0.20	0.38	0.49	1.00	0.57	0.46	0.44	0.51	0.50	0.59	0.46	0.72	0.51	0.60	0.41	0.58	1.00	0.44	0.57	0.48	0.53	0.56	0.42	0.50	0.43	0.43	0.46	0.51	0.59	0.42	0.46	0.53	0.59	0.53	0.47
998 (CDC42)	0.58	0.64	0.60	0.62	0.55	0.51	0.62	0.60	0.49	0.69	0.61	0.71	0.59	0.59	0.54	1.00	0.23	0.45	0.57	0.57	1.00	0.54	0.53	0.78	0.57	0.88	0.51	0.50	0.55	0.66	0.49	0.56	1.00	0.53	0.61	0.53	0.61	0.58	0.44	0.57	0.76	0.47	0.53	0.56	0.58	0.51	0.56	0.59	0.52	0.64	0.55
3845 (KRAS)	0.77	0.58	0.76	0.65	0.67	0.66	0.71	0.50	0.61	0.53	0.65	0.57	0.70	0.63	0.74	1.00	0.27	0.49	0.79	0.46	0.54	1.00	0.74	0.59	0.82	0.58	0.67	0.47	0.68	0.71	0.61	0.59	1.00	0.74	0.65	0.56	0.80	0.72	0.36	0.67	0.55	0.51	0.63	0.78	0.65	0.69	0.80	0.62	0.50	0.72	0.82
7791 (ZYX)	0.74	0.64	0.73	0.63	0.64	0.61	0.69	0.48	0.56	0.51	0.63	0.54	0.83	0.62	0.69	1.00	0.39	0.45	0.75	0.44	0.53	0.74	1.00	0.58	0.77	0.57	0.56	0.45	0.65	0.77	0.56	0.57	1.00	1.00	0.63	0.65	0.74	0.65	0.33	0.82	0.54	0.49	0.60	0.74	0.63	0.63	0.74	0.61	0.47	0.69	0.76
387 (RHOA)	0.64	0.59	0.65	0.64	0.58	0.53	0.67	0.47	0.50	0.56	0.61	0.51	0.61	0.62	0.58	1.00	0.24	0.44	0.62	0.51	0.78	0.59	0.58	1.00	0.63	0.85	0.53	0.48	0.58	0.68	0.50	0.58	1.00	0.58	0.61	0.54	0.71	0.61	0.41	0.62	0.90	0.50	0.54	0.61	0.61	0.53	0.60	0.59	0.45	0.69	0.61
2017 (CTTN)	0.79	0.60	0.84	0.67	0.70	0.70	0.73	0.54	0.66	0.56	0.67	0.61	0.80	0.65	0.77	1.00	0.27	0.54	0.81	0.50	0.57	0.82	0.77	0.63	1.00	0.61	0.62	0.50	0.78	0.76	0.66	0.61	1.00	0.77	0.67	0.57	0.82	0.73	0.41	0.70	0.60	0.53	0.67	0.84	0.71	0.73	0.82	0.64	0.55	0.75	0.96
5879 (RAC1)	0.63	0.64	0.64	0.64	0.57	0.54	0.65	0.60	0.51	0.72	0.63	0.73	0.60	0.62	0.57	1.00	0.24	0.46	0.62	0.59	0.88	0.58	0.57	0.85	0.61	1.00	0.53	0.52	0.57	0.67	0.51	0.57	1.00	0.57	0.63	0.54	0.66	0.61	0.44	0.61	0.82	0.49	0.54	0.59	0.60	0.54	0.58	0.59	0.54	0.65	0.59
3673 (ITGA2)	0.62	0.54	0.64	0.59	0.58	0.55	0.62	0.48	0.51	0.49	0.68	0.51	0.59	0.63	0.58	1.00	0.27	0.46	0.60	0.46	0.51	0.67	0.56	0.53	0.62	0.53	1.00	0.47	0.59	0.65	0.51	0.56	1.00	0.56	0.66	0.54	0.59	0.76	0.38	0.56	0.52	0.64	0.66	0.61	0.58	0.70	0.59	0.60	0.47	0.59	0.59
5728 (PTEN)	0.52	0.51	0.54	0.55	0.49	0.45	0.54	0.47	0.43	0.46	0.58	0.49	0.52	0.55	0.47	1.00	0.20	0.40	0.52	0.72	0.50	0.47	0.45	0.48	0.50	0.52	0.47	1.00	0.50	0.60	0.43	0.49	1.00	0.45	0.59	0.48	0.48	0.56	0.47	0.48	0.46	0.44	0.48	0.49	0.51	0.44	0.48	0.55	0.41	0.51	0.47
7094 (TLN1)	0.75	0.58	0.75	0.63	0.72	0.62	0.68	0.53	0.59	0.54	0.72	0.56	0.71	0.67	0.66	1.00	0.25	0.51	0.69	0.51	0.55	0.68	0.65	0.58	0.78	0.57	0.59	0.50	1.00	0.73	0.59	0.61	1.00	0.65	0.68	0.60	0.68	0.73	0.41	0.63	0.55	0.52	0.61	0.81	0.68	0.62	0.68	0.62	0.52	0.66	0.77
7430 (EZR)	0.72	0.70	0.78	0.76	0.69	0.74	0.73	0.62	0.66	0.67	0.70	0.65	0.80	0.67	0.70	1.00	0.32	0.61	0.71	0.60	0.66	0.71	0.77	0.68	0.76	0.67	0.65	0.60	0.73	1.00	0.66	0.65	1.00	0.77	0.71	0.75	0.74	0.75	0.53	0.75	0.64	0.62	0.68	0.75	0.70	0.68	0.72	0.66	0.61	0.74	0.75
2889 (RAPGEF1)	0.66	0.64	0.67	0.62	0.58	0.60	0.64	0.61	0.90	0.62	0.59	0.49	0.61	0.59	0.59	1.00	0.28	0.84	0.64	0.41	0.49	0.61	0.56	0.50	0.66	0.51	0.51	0.43	0.59	0.66	1.00	0.67	1.00	0.56	0.61	0.50	0.61	0.62	0.33	0.57	0.46	0.46	0.54	0.63	0.61	0.52	0.61	0.59	0.71	0.60	0.63
6464 (SHC1)	0.62	0.77	0.63	0.63	0.65	0.58	0.74	0.59	0.67	0.62	0.66	0.53	0.65	0.62	0.61	1.00	0.33	0.67	0.60	0.58	0.56	0.59	0.57	0.58	0.61	0.57	0.56	0.49	0.61	0.65	0.67	1.00	1.00	0.57	0.63	0.55	0.63	0.62	0.43	0.60	0.54	0.51	0.57	0.63	0.69	0.56	0.59	0.63	0.66	0.69	0.60
9815 (GIT2)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.38	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
7145 (TNS1)	0.74	0.64	0.73	0.63	0.64	0.61	0.69	0.48	0.56	0.51	0.63	0.54	0.83	0.62	0.69	1.00	0.39	0.45	0.75	0.44	0.53	0.74	1.00	0.58	0.77	0.57	0.56	0.45	0.65	0.77	0.56	0.57	1.00	1.00	0.63	0.65	0.74	0.65	0.33	0.82	0.54	0.49	0.60	0.74	0.63	0.63	0.74	0.61	0.47	0.69	0.76
3690 (ITGB3)	0.67	0.62	0.68	0.67	0.68	0.63	0.66	0.59	0.61	0.59	0.72	0.63	0.66	0.85	0.73	1.00	0.25	0.57	0.69	0.57	0.61	0.65	0.63	0.61	0.67	0.63	0.66	0.59	0.68	0.71	0.61	0.63	1.00	0.63	1.00	0.62	0.65	0.81	0.53	0.65	0.59	0.69	0.67	0.72	0.65	0.68	0.65	0.76	0.57	0.66	0.66
81 (ACTN4)	0.58	0.60	0.64	0.60	0.61	0.58	0.58	0.49	0.50	0.53	0.62	0.51	0.67	0.60	0.54	1.00	0.46	0.46	0.56	0.48	0.53	0.56	0.65	0.54	0.57	0.54	0.54	0.48	0.60	0.75	0.50	0.55	1.00	0.65	0.62	1.00	0.54	0.66	0.41	0.69	0.54	0.52	0.57	0.62	0.57	0.51	0.60	0.59	0.47	0.56	0.55
9564 (BCAR1)	0.77	0.63	0.76	0.72	0.67	0.66	0.77	0.50	0.61	0.62	0.66	0.57	0.70	0.67	0.74	1.00	0.26	0.49	0.80	0.53	0.61	0.80	0.74	0.71	0.82	0.66	0.59	0.48	0.68	0.74	0.61	0.63	1.00	0.74	0.65	0.54	1.00	0.67	0.36	0.73	0.55	0.51	0.64	0.78	0.68	0.69	0.80	0.62	0.50	0.86	0.82
3688 (ITGB1)	0.68	0.60	0.75	0.65	0.70	0.65	0.67	0.57	0.62	0.60	0.72	0.61	0.69	0.79	0.66	1.00	0.26	0.57	0.75	0.56	0.58	0.72	0.65	0.61	0.73	0.61	0.76	0.56	0.73	0.75	0.62	0.62	1.00	0.65	0.81	0.66	0.67	1.00	0.50	0.64	0.59	0.73	0.68	0.77	0.67	0.71	0.67	0.67	0.57	0.66	0.72
836 (CASP3)	0.44	0.45	0.48	0.46	0.41	0.37	0.49	0.54	0.33	0.40	0.47	0.41	0.43	0.49	0.37	1.00	0.22	0.34	0.40	0.42	0.44	0.36	0.33	0.41	0.41	0.44	0.38	0.47	0.41	0.53	0.33	0.43	1.00	0.33	0.53	0.41	0.36	0.50	1.00	0.39	0.38	0.39	0.38	0.39	0.48	0.33	0.36	0.50	0.34	0.39	0.37
7205 (TRIP6)	0.69	0.67	0.70	0.65	0.66	0.60	0.69	0.50	0.57	0.57	0.65	0.55	0.76	0.63	0.70	1.00	0.35	0.49	0.69	0.50	0.57	0.67	0.82	0.62	0.70	0.61	0.56	0.48	0.63	0.75	0.57	0.60	1.00	0.82	0.65	0.69	0.73	0.64	0.39	1.00	0.56	0.51	0.60	0.68	0.65	0.61	0.67	0.66	0.50	0.70	0.69
3265 (HRAS)	0.61	0.53	0.63	0.56	0.55	0.49	0.61	0.45	0.46	0.47	0.62	0.48	0.59	0.57	0.54	1.00	0.25	0.41	0.58	0.43	0.76	0.55	0.54	0.90	0.60	0.82	0.52	0.46	0.55	0.64	0.46	0.54	1.00	0.54	0.59	0.54	0.55	0.59	0.38	0.56	1.00	0.46	0.51	0.57	0.57	0.49	0.55	0.59	0.43	0.58	0.57
7852 (CXCR4)	0.55	0.51	0.64	0.54	0.52	0.50	0.56	0.45	0.46	0.49	0.54	0.48	0.53	0.68	0.51	1.00	0.21	0.43	0.52	0.43	0.47	0.51	0.49	0.50	0.53	0.49	0.64	0.44	0.52	0.62	0.46	0.51	1.00	0.49	0.69	0.52	0.51	0.73	0.39	0.51	0.46	1.00	0.65	0.52	0.54	0.73	0.51	0.55	0.44	0.52	0.51
2207 (FCER1G)	0.67	0.56	0.67	0.61	0.61	0.58	0.65	0.50	0.54	0.51	0.63	0.54	0.64	0.65	0.62	1.00	0.24	0.47	0.66	0.46	0.53	0.63	0.60	0.54	0.67	0.54	0.66	0.48	0.61	0.68	0.54	0.57	1.00	0.60	0.67	0.57	0.64	0.68	0.38	0.60	0.51	0.65	1.00	0.65	0.61	0.77	0.75	0.64	0.48	0.64	0.65
3695 (ITGB7)	0.77	0.59	0.78	0.66	0.79	0.68	0.72	0.52	0.63	0.54	0.72	0.58	0.73	0.70	0.73	1.00	0.26	0.51	0.78	0.51	0.56	0.78	0.74	0.61	0.84	0.59	0.61	0.49	0.81	0.75	0.63	0.63	1.00	0.74	0.72	0.62	0.78	0.77	0.39	0.68	0.57	0.52	0.65	1.00	0.68	0.69	0.78	0.63	0.53	0.72	0.84
4690 (NCK1)	0.68	0.66	0.71	0.66	0.68	0.64	0.75	0.56	0.61	0.58	0.66	0.58	0.74	0.63	0.66	1.00	0.27	0.56	0.66	0.59	0.58	0.65	0.63	0.61	0.71	0.60	0.58	0.51	0.68	0.70	0.61	0.69	1.00	0.63	0.65	0.57	0.68	0.67	0.48	0.65	0.57	0.54	0.61	0.68	1.00	0.62	0.65	0.65	0.56	0.66	0.70
1630 (DCC)	0.71	0.55	0.71	0.61	0.62	0.57	0.68	0.46	0.52	0.49	0.62	0.52	0.65	0.67	0.65	1.00	0.24	0.42	0.71	0.42	0.51	0.69	0.63	0.53	0.73	0.54	0.70	0.44	0.62	0.68	0.52	0.56	1.00	0.63	0.68	0.51	0.69	0.71	0.33	0.61	0.49	0.73	0.77	0.69	0.62	1.00	0.69	0.60	0.45	0.65	0.71
5175 (PECAM1)	0.77	0.59	0.76	0.66	0.67	0.66	0.72	0.52	0.61	0.53	0.66	0.59	0.72	0.64	0.74	1.00	0.26	0.49	0.80	0.46	0.56	0.80	0.74	0.60	0.82	0.58	0.59	0.48	0.68	0.72	0.61	0.59	1.00	0.74	0.65	0.60	0.80	0.67	0.36	0.67	0.55	0.51	0.75	0.78	0.65	0.69	1.00	0.67	0.50	0.75	0.82
7422 (VEGFA)	0.64	0.62	0.65	0.63	0.67	0.60	0.64	0.66	0.59	0.56	0.72	0.60	0.64	0.65	0.76	1.00	0.28	0.56	0.67	0.53	0.59	0.62	0.61	0.59	0.64	0.59	0.60	0.55	0.62	0.66	0.59	0.63	1.00	0.61	0.76	0.59	0.62	0.67	0.50	0.66	0.59	0.55	0.64	0.63	0.65	0.60	0.67	1.00	0.56	0.66	0.63
7409 (VAV1)	0.57	0.75	0.59	0.56	0.52	0.51	0.64	0.71	0.78	0.68	0.55	0.59	0.60	0.55	0.50	1.00	0.34	0.74	0.53	0.59	0.52	0.50	0.47	0.45	0.55	0.54	0.47	0.41	0.52	0.61	0.71	0.66	1.00	0.47	0.57	0.47	0.50	0.57	0.34	0.50	0.43	0.44	0.48	0.53	0.56	0.45	0.50	0.56	1.00	0.52	0.51
2886 (GRB7)	0.73	0.64	0.73	0.73	0.65	0.64	0.74	0.55	0.60	0.62	0.69	0.61	0.72	0.66	0.69	1.00	0.38	0.51	0.73	0.53	0.64	0.72	0.69	0.69	0.75	0.65	0.59	0.51	0.66	0.74	0.60	0.69	1.00	0.69	0.66	0.56	0.86	0.66	0.39	0.70	0.58	0.52	0.64	0.72	0.66	0.65	0.75	0.66	0.52	1.00	0.74
50807 (ASAP1)	0.78	0.59	0.84	0.66	0.69	0.68	0.72	0.51	0.63	0.53	0.66	0.58	0.79	0.64	0.76	1.00	0.26	0.50	0.81	0.47	0.55	0.82	0.76	0.61	0.96	0.59	0.59	0.47	0.77	0.75	0.63	0.60	1.00	0.76	0.66	0.55	0.82	0.72	0.37	0.69	0.57	0.51	0.65	0.84	0.70	0.71	0.82	0.63	0.51	0.74	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
PTK2	Human	Blood	-	3250 m	4 day	downregulated	-1.55	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776
PTK2	Human	Blood	-	3250 m	4 day	downregulated	-1.55	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776
PTK2	Human	Blood	-	3250 m	4 day	downregulated	-1.55	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776
PTK2	Human	Blood	-	3250 m	4 day	downregulated	-1.55	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776
PTK2	Human	Blood	-	3250 m	4 day	downregulated	-1.55	Microarray	Himalayas	Indians	1	Sea level healthy individuals	24465776

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
EP300	2033	PTK2	5747	distal	22955619	TRANSFAC
TCF12	6938	PTK2	5747	distal	22955619	TRANSFAC

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT004001	hsa-miR-193a-3p	Homo sapiens	PTK2	5747	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Non-Functional MTI	18381414
MIRT006388	hsa-miR-138-5p	Homo sapiens	PTK2	5747	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	21444814
MIRT006900	hsa-miR-7-5p	Homo sapiens	PTK2	5747	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27764812
MIRT006900	hsa-miR-7-5p	Homo sapiens	PTK2	5747	Homo sapiens	Immunoblot//Immunohistochemistry//Luciferase reporter assay//qRT-PCR	Functional MTI	22876288
MIRT006900	hsa-miR-7-5p	Homo sapiens	PTK2	5747	Homo sapiens	Luciferase reporter assay	Functional MTI	25785020
MIRT030918	hsa-miR-21-5p	Homo sapiens	PTK2	5747	Homo sapiens	Microarray	Functional MTI (Weak)	18591254
MIRT051491	hsa-let-7e-5p	Homo sapiens	PTK2	5747	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT051867	hsa-let-7c-5p	Homo sapiens	PTK2	5747	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT053172	hsa-miR-543	Homo sapiens	PTK2	5747	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	24699721
MIRT732163	hsa-miR-379-5p	Homo sapiens	PTK2	5747	Homo sapiens	Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26944318
MIRT734221	hsa-miR-135a-5p	Homo sapiens	PTK2	5747	Homo sapiens	ChIP-seq//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	28415713

Gene Ontology

ID	GO ID	GO Term	GO Type
5747	GO:0019901	protein kinase binding	GOTERM_MF_DIRECT
5747	GO:0000165	MAPK cascade	GOTERM_BP_DIRECT
5747	GO:0008360	regulation of cell shape	GOTERM_BP_DIRECT
5747	GO:0030010	establishment of cell polarity	GOTERM_BP_DIRECT
5747	GO:0043547	positive regulation of GTPase activity	GOTERM_BP_DIRECT
5747	GO:0048870	cell motility	GOTERM_BP_DIRECT
5747	GO:0004713	protein tyrosine kinase activity	GOTERM_MF_DIRECT
5747	GO:0001525	angiogenesis	GOTERM_BP_DIRECT
5747	GO:0001932	regulation of protein phosphorylation	GOTERM_BP_DIRECT
5747	GO:0009790	embryo development	GOTERM_BP_DIRECT
5747	GO:0051893	regulation of focal adhesion assembly	GOTERM_BP_DIRECT
5747	GO:0005515	protein binding	GOTERM_MF_DIRECT
5747	GO:0010594	regulation of endothelial cell migration	GOTERM_BP_DIRECT
5747	GO:0010632	regulation of epithelial cell migration	GOTERM_BP_DIRECT
5747	GO:0022408	negative regulation of cell-cell adhesion	GOTERM_BP_DIRECT
5747	GO:0042127	regulation of cell proliferation	GOTERM_BP_DIRECT
5747	GO:0045087	innate immune response	GOTERM_BP_DIRECT
5747	GO:0001890	placenta development	GOTERM_BP_DIRECT
5747	GO:0006921	cellular component disassembly involved in execution phase of apoptosis	GOTERM_BP_DIRECT
5747	GO:0007173	epidermal growth factor receptor signaling pathway	GOTERM_BP_DIRECT
5747	GO:0005856	cytoskeleton	GOTERM_CC_DIRECT
5747	GO:0045667	regulation of osteoblast differentiation	GOTERM_BP_DIRECT
5747	GO:0045860	positive regulation of protein kinase activity	GOTERM_BP_DIRECT
5747	GO:0005634	nucleus	GOTERM_CC_DIRECT
5747	GO:0030027	lamellipodium	GOTERM_CC_DIRECT
5747	GO:0001570	vasculogenesis	GOTERM_BP_DIRECT
5747	GO:0007229	integrin-mediated signaling pathway	GOTERM_BP_DIRECT
5747	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GOTERM_BP_DIRECT
5747	GO:0018108	peptidyl-tyrosine phosphorylation	GOTERM_BP_DIRECT
5747	GO:0033628	regulation of cell adhesion mediated by integrin	GOTERM_BP_DIRECT
5747	GO:0046777	protein autophosphorylation	GOTERM_BP_DIRECT
5747	GO:0001764	neuron migration	GOTERM_BP_DIRECT
5747	GO:0021955	central nervous system neuron axonogenesis	GOTERM_BP_DIRECT
5747	GO:0004871	signal transducer activity	GOTERM_MF_DIRECT
5747	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GOTERM_CC_DIRECT
5747	GO:0008284	positive regulation of cell proliferation	GOTERM_BP_DIRECT
5747	GO:0008432	phosphatidylethanolamine binding	GOTERM_MF_DIRECT
5747	GO:0005815	microtubule organizing center	GOTERM_CC_DIRECT
5747	GO:0016324	apical plasma membrane	GOTERM_CC_DIRECT
5747	GO:0048013	ephrin receptor signaling pathway	GOTERM_BP_DIRECT
5747	GO:0051493	regulation of cytoskeleton organization	GOTERM_BP_DIRECT
5747	GO:0051964	negative regulation of synapse assembly	GOTERM_BP_DIRECT
5747	GO:0038007	netrin-activated signaling pathway	GOTERM_BP_DIRECT
5747	GO:0038083	peptidyl-tyrosine autophosphorylation	GOTERM_BP_DIRECT
5747	GO:0043542	endothelial cell migration	GOTERM_BP_DIRECT
5747	GO:0001725	stress fiber	GOTERM_CC_DIRECT
5747	GO:0005829	cytosol	GOTERM_CC_DIRECT
5747	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
5747	GO:0000226	microtubule cytoskeleton organization	GOTERM_BP_DIRECT
5747	GO:0001934	positive regulation of protein phosphorylation	GOTERM_BP_DIRECT
5747	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GOTERM_BP_DIRECT
5747	GO:0004672	protein kinase activity	GOTERM_MF_DIRECT
5747	GO:0042169	chemoattractant activity	GOTERM_MF_DIRECT
5747	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GOTERM_BP_DIRECT
5747	GO:0003779	actin binding	GOTERM_MF_DIRECT
5747	GO:0005925	focal adhesion	GOTERM_CC_DIRECT
5747	GO:0030198	extracellular matrix organization	GOTERM_BP_DIRECT
5747	GO:0040023	establishment of nucleus localization	GOTERM_BP_DIRECT
5747	GO:2000811	negative regulation of anoikis	GOTERM_BP_DIRECT
5747	GO:0005938	cell cortex	GOTERM_CC_DIRECT
5747	GO:0003007	heart morphogenesis	GOTERM_BP_DIRECT
5747	GO:0007172	signal complex assembly	GOTERM_BP_DIRECT
5747	GO:0007411	axon guidance	GOTERM_BP_DIRECT
5747	GO:0030335	positive regulation of cell migration	GOTERM_BP_DIRECT
5747	GO:0043066	negative regulation of apoptotic process	GOTERM_BP_DIRECT
5747	GO:0050771	negative regulation of axonogenesis	GOTERM_BP_DIRECT
5747	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GOTERM_MF_DIRECT
5747	GO:0005102	receptor binding	GOTERM_MF_DIRECT
5747	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
5747	GO:0007179	transforming growth factor beta receptor signaling pathway	GOTERM_BP_DIRECT
5747	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	GOTERM_BP_DIRECT
5747	GO:0060396	growth hormone receptor signaling pathway	GOTERM_BP_DIRECT
5747	GO:1900024	regulation of substrate adhesion-dependent cell spreading	GOTERM_BP_DIRECT
5747	GO:0005524	ATP binding	GOTERM_MF_DIRECT
5747	GO:0043087	regulation of GTPase activity	GOTERM_BP_DIRECT
5747	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GOTERM_BP_DIRECT
5747	GO:0046621	negative regulation of organ growth	GOTERM_BP_DIRECT
5747	GO:0051897	positive regulation of protein kinase B signaling	GOTERM_BP_DIRECT
5747	GO:0005088	Ras guanyl-nucleotide exchange factor activity	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
5747	hsa04012	ErbB signaling pathway
5747	hsa04062	Chemokine signaling pathway
5747	hsa04151	PI3K-Akt signaling pathway
5747	hsa04360	Axon guidance
5747	hsa04510	Focal adhesion
5747	hsa04370	VEGF signaling pathway
5747	hsa04670	Leukocyte transendothelial migration
5747	hsa04810	Regulation of actin cytoskeleton
5747	hsa05100	Bacterial invasion of epithelial cells
5747	hsa05146	Amoebiasis
5747	hsa05200	Pathways in cancer
5747	hsa05205	Proteoglycans in cancer
5747	hsa05202	Transcriptional misregulation in cancer
5747	hsa05222	Small cell lung cancer

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
PTK2	5747	Rheumatoid Arthritis	C0003873	Disease or Syndrome	0.3	0.545	0.655	disease
PTK2	5747	Squamous cell carcinoma	C0007137	Neoplastic Process	0.36	0.545	0.655	disease
PTK2	5747	Mouth Neoplasms	C0026640	Neoplastic Process	0.3	0.545	0.655	group
PTK2	5747	Giant Cell Glioblastoma	C0334588	Neoplastic Process	0.3	0.545	0.655	disease
PTK2	5747	Liver carcinoma	C2239176	Neoplastic Process	0.4	0.545	0.655	disease
PTK2	5747	Malignant neoplasm of mouth	C0153381	Neoplastic Process	0.3	0.545	0.655	disease
PTK2	5747	Mammary Neoplasms, Experimental	C0024668	Experimental Model of Disease; Neoplastic Process	0.3	0.545	0.655	group
PTK2	5747	Neoplastic Cell Transformation	C0007621	Neoplastic Process	0.3	0.545	0.655	phenotype
PTK2	5747	Glioblastoma	C0017636	Neoplastic Process	0.35	0.545	0.655	disease
PTK2	5747	Neoplasm Invasiveness	C0027626	Pathologic Function	0.3	0.545	0.655	phenotype
PTK2	5747	Glioblastoma Multiforme	C1621958	Neoplastic Process	0.5	0.545	0.655	disease
PTK2	5747	Metastatic melanoma	C0278883	Neoplastic Process	0.3	0.545	0.655	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
PTK2	5747	BI-853520	BI-853520	CHEMBL3544961	inhibitor
PTK2	5747	CEP-37440	CEP-37440	CHEMBL3545051	inhibitor
PTK2	5747	COMPOUND 30 [PMID: 23414845]	None	None	inhibitor
PTK2	5747	DEFACTINIB	DEFACTINIB	CHEMBL3137331	inhibitor
PTK2	5747	ENMD-2076	ENMD-2076	CHEMBL482968	inhibitor
PTK2	5747	ENMD-2076	ENMD-2076	CHEMBL482968	None
PTK2	5747	GSK-2256098	GSK-2256098	CHEMBL3544967	inhibitor
PTK2	5747	MASITINIB	MASITINIB	CHEMBL1908391	inhibitor
PTK2	5747	None	None	None	None
PTK2	5747	NVP-TAE 226	CHEMBL458997	CHEMBL458997	inhibitor
PTK2	5747	PF-04554878	DEFACTINIB	CHEMBL3137331	None
PTK2	5747	PF-562271	PF-562271	CHEMBL1084546	inhibitor
PTK2	5747	PF00562271	PF-562271	CHEMBL1084546	inhibitor
PTK2	5747	PF-562271	PF-562271	CHEMBL1084546	inhibitor
PTK2	5747	PF-00562271	PF-562271	CHEMBL1084546	inhibitor
PTK2	5747	PMA	PHORBOL MYRISTATE ACETATE	CHEMBL279115	None
PTK2	5747	VS-4718	VS-4718	CHEMBL3544933	inhibitor
PTK2	5747	VS-4718	VS-4718	CHEMBL3544933	inhibitor