Suppressor of cytokine signaling 3
AltitudeomicsDB
Protein Official symbol |
SOCS3 |
Aliases |
SOCS3 CIS3 SSI3 |
Chromosomal Location |
17 |
Length |
225 |
Uniprot ID |
O14543 |
EC number |
None |
Protein family Information(Pfam) |
PF00017;PF07525; |
PDB id |
None |
InterPro ID |
IPR000980;IPR036860;IPR028414;IPR035863;IPR001496;IPR036036; |
dbSNP |
rs1061489 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
JAK2 |
STAT5B |
0.999 |
JAK2 |
STAT5A |
0.999 |
TCEB1 |
CUL2 |
0.999 |
IL2RA |
IL2 |
0.999 |
CUL2 |
VHL |
0.999 |
CUL5 |
RNF7 |
0.999 |
IL6 |
IL6R |
0.999 |
CUL5 |
TCEB2 |
0.999 |
EPO |
EPOR |
0.999 |
TCEB1 |
VHL |
0.999 |
TCEB1 |
CUL5 |
0.999 |
PTPN11 |
IRS1 |
0.999 |
TCEB1 |
TCEB2 |
0.999 |
CUL2 |
TCEB2 |
0.999 |
TCEB2 |
VHL |
0.998 |
TCEB1 |
SOCS3 |
0.998 |
JAK2 |
STAT3 |
0.998 |
TYK2 |
IFNAR1 |
0.998 |
SOCS3 |
TCEB2 |
0.998 |
LEPR |
LEP |
0.998 |
JAK2 |
STAT1 |
0.998 |
IL6 |
STAT3 |
0.997 |
JAK3 |
STAT5A |
0.997 |
JAK3 |
STAT5B |
0.997 |
JAK1 |
STAT3 |
0.997 |
IL6 |
IL6ST |
0.997 |
SOCS2 |
TCEB2 |
0.997 |
IFNGR1 |
IFNG |
0.997 |
TCEB1 |
RNF7 |
0.997 |
STAT1 |
JAK1 |
0.997 |
SOCS2 |
TCEB1 |
0.997 |
IFNB1 |
IFNAR1 |
0.996 |
GHR |
GH1 |
0.996 |
JAK1 |
STAT5A |
0.996 |
IL2 |
IL2RB |
0.996 |
IL2RA |
IL2RB |
0.996 |
JAK1 |
STAT5B |
0.996 |
HRAS |
RASA1 |
0.996 |
IL23R |
IL23A |
0.996 |
TYK2 |
STAT2 |
0.995 |
SOCS3 |
STAT3 |
0.995 |
HRAS |
KRAS |
0.995 |
JAK2 |
EPOR |
0.995 |
JAK2 |
SOCS3 |
0.994 |
TYK2 |
STAT1 |
0.994 |
SOCS2 |
CUL5 |
0.994 |
JAK3 |
STAT3 |
0.994 |
STAT1 |
IFNAR1 |
0.993 |
JAK2 |
STAT2 |
0.992 |
LEP |
STAT3 |
0.992 |
JAK2 |
SOCS1 |
0.992 |
JAK2 |
PTPN11 |
0.992 |
IL6R |
STAT3 |
0.992 |
IL6 |
SOCS3 |
0.992 |
CUL2 |
RNF7 |
0.992 |
JAK1 |
STAT2 |
0.991 |
IFNGR1 |
IFNGR2 |
0.991 |
STAT5A |
IL2 |
0.991 |
IL6ST |
IL6R |
0.991 |
TCEB1 |
SOCS1 |
0.991 |
STAT5B |
IL2 |
0.991 |
PTPN11 |
STAT3 |
0.991 |
IFNGR1 |
STAT1 |
0.99 |
TCEB1 |
CISH |
0.99 |
LEPR |
SOCS3 |
0.99 |
JAK2 |
LEPR |
0.99 |
LEPR |
STAT3 |
0.99 |
RNF7 |
TCEB2 |
0.99 |
JAK1 |
STAT6 |
0.99 |
STAT5A |
EPOR |
0.989 |
SOCS3 |
LEP |
0.989 |
GHR |
JAK2 |
0.989 |
TCEB1 |
SOCS5 |
0.989 |
JAK3 |
STAT6 |
0.989 |
STAT1 |
IFNG |
0.989 |
JAK1 |
PTPN11 |
0.988 |
STAT2 |
IFNAR1 |
0.988 |
JAK2 |
EPO |
0.988 |
TYK2 |
STAT3 |
0.988 |
IL2RA |
STAT5B |
0.987 |
PTPN11 |
SOCS3 |
0.987 |
IL6ST |
STAT3 |
0.987 |
IL23R |
STAT3 |
0.987 |
SOCS3 |
IRS1 |
0.987 |
JAK1 |
IFNAR1 |
0.986 |
CISH |
TCEB2 |
0.986 |
SOCS1 |
TCEB2 |
0.986 |
JAK3 |
STAT1 |
0.986 |
STAT1 |
PTPN11 |
0.986 |
STAT1 |
SOCS3 |
0.986 |
JAK2 |
IRS1 |
0.985 |
SOCS2 |
JAK2 |
0.984 |
CISH |
STAT5A |
0.984 |
SOCS1 |
STAT3 |
0.984 |
JAK2 |
LEP |
0.984 |
CISH |
CUL5 |
0.984 |
IL6 |
STAT1 |
0.983 |
SOCS2 |
STAT5A |
0.983 |
CUL5 |
SOCS5 |
0.983 |
PTPN6 |
JAK2 |
0.983 |
JAK1 |
SOCS3 |
0.983 |
GHR |
STAT5B |
0.983 |
CISH |
STAT5B |
0.982 |
JAK2 |
STAT6 |
0.982 |
HRAS |
PTPN11 |
0.982 |
GHR |
STAT5A |
0.982 |
JAK2 |
SOCS5 |
0.982 |
JAK1 |
SOCS1 |
0.982 |
LEP |
IRS1 |
0.982 |
STAT5B |
EPOR |
0.982 |
JAK2 |
IRS2 |
0.982 |
SOCS2 |
STAT5B |
0.982 |
HRAS |
JAK2 |
0.981 |
IL6 |
STAT6 |
0.981 |
JAK3 |
IL2 |
0.981 |
IL12RB1 |
IL23R |
0.98 |
JAK2 |
IL23R |
0.98 |
IFNGR1 |
JAK1 |
0.979 |
JAK2 |
SH2B3 |
0.979 |
JAK1 |
IFNGR2 |
0.979 |
JAK2 |
IFNGR1 |
0.979 |
IL2RA |
STAT5A |
0.979 |
IL12RB1 |
TYK2 |
0.979 |
JAK1 |
IRS1 |
0.978 |
JAK3 |
SOCS1 |
0.978 |
PTPN6 |
STAT5B |
0.978 |
TYK2 |
SOCS1 |
0.978 |
JAK1 |
SOCS5 |
0.978 |
JAK3 |
SOCS3 |
0.977 |
SOCS5 |
TCEB2 |
0.977 |
SOCS1 |
IRS1 |
0.977 |
PTPN11 |
KRAS |
0.976 |
JAK3 |
SOCS5 |
0.976 |
STAT5A |
STAT3 |
0.976 |
STAT5A |
EPO |
0.976 |
LCK |
STAT3 |
0.976 |
CUL2 |
CISH |
0.976 |
IL6R |
SOCS3 |
0.976 |
JAK2 |
IFNGR2 |
0.976 |
JAK3 |
PTPN6 |
0.975 |
STAT1 |
STAT5A |
0.975 |
IL6 |
JAK2 |
0.975 |
LCK |
STAT5B |
0.974 |
TYK2 |
STAT5A |
0.974 |
STAT5B |
EPO |
0.974 |
PTPN6 |
IRS1 |
0.974 |
TYK2 |
STAT5B |
0.974 |
SOCS1 |
STAT6 |
0.973 |
GHR |
SOCS3 |
0.973 |
CISH |
JAK2 |
0.973 |
IL6ST |
JAK1 |
0.973 |
IL6R |
JAK1 |
0.973 |
STAT5A |
SOCS3 |
0.973 |
SOCS3 |
STAT5B |
0.973 |
IFNB1 |
STAT1 |
0.972 |
STAT5A |
IL2RB |
0.972 |
SOCS1 |
IL2 |
0.972 |
STAT1 |
STAT3 |
0.972 |
IFNGR1 |
SOCS1 |
0.972 |
CISH |
STAT3 |
0.972 |
SOCS1 |
IFNAR1 |
0.972 |
PTPN6 |
STAT5A |
0.971 |
STAT5A |
LCK |
0.971 |
JAK3 |
PTPN11 |
0.971 |
CUL5 |
SOCS3 |
0.971 |
STAT1 |
STAT2 |
0.971 |
STAT5B |
IL2RB |
0.97 |
LCK |
IL2RB |
0.97 |
GHR |
SOCS2 |
0.97 |
STAT5A |
SOCS1 |
0.97 |
IFNB1 |
SOCS1 |
0.97 |
JAK3 |
IL2RB |
0.97 |
SOCS3 |
SOCS5 |
0.969 |
STAT3 |
IL2 |
0.969 |
TYK2 |
STAT6 |
0.969 |
GHR |
CISH |
0.969 |
SOCS3 |
IL2 |
0.969 |
SOCS3 |
RASA1 |
0.969 |
LCK |
IL2 |
0.969 |
SOCS1 |
STAT5B |
0.969 |
PTK6 |
STAT3 |
0.968 |
RASA1 |
KRAS |
0.968 |
IL6ST |
SOCS3 |
0.968 |
CISH |
JAK1 |
0.968 |
PTPN11 |
IL2 |
0.968 |
IFNGR2 |
IFNG |
0.968 |
IL6 |
JAK1 |
0.968 |
IL12RB1 |
IL23A |
0.967 |
TYK2 |
SOCS3 |
0.967 |
CUL5 |
VHL |
0.967 |
IL6ST |
STAT1 |
0.967 |
JAK3 |
IL2RA |
0.967 |
IL2RA |
STAT3 |
0.966 |
PTPN6 |
JAK1 |
0.966 |
IRS2 |
LEP |
0.966 |
SOCS3 |
STAT6 |
0.966 |
HRAS |
IL2 |
0.965 |
STAT1 |
IL2 |
0.965 |
SOCS3 |
STAT2 |
0.965 |
IL6ST |
PTPN11 |
0.965 |
IFNB1 |
STAT2 |
0.965 |
JAK2 |
IL6ST |
0.965 |
SOCS1 |
STAT2 |
0.965 |
JAK1 |
IL2 |
0.965 |
SOCS3 |
RNF7 |
0.965 |
CUL5 |
SOCS1 |
0.964 |
STAT1 |
LCK |
0.964 |
CISH |
RNF7 |
0.964 |
CUL2 |
SOCS1 |
0.964 |
IL12RB1 |
STAT1 |
0.963 |
SOCS3 |
EPO |
0.963 |
SOCS3 |
EPOR |
0.963 |
JAK1 |
IL2RB |
0.963 |
TYK2 |
IL23R |
0.963 |
SOCS2 |
RNF7 |
0.963 |
JAK2 |
KRAS |
0.962 |
PTPN6 |
STAT6 |
0.962 |
SOCS3 |
IFNG |
0.962 |
SOCS2 |
JAK1 |
0.962 |
PTPN6 |
LCK |
0.962 |
TYK2 |
IL6 |
0.961 |
STAT5B |
STAT3 |
0.961 |
TYK2 |
PTPN6 |
0.96 |
GHR |
IRS1 |
0.96 |
JAK3 |
IL6 |
0.959 |
IL6 |
IL2 |
0.959 |
PTPN11 |
STAT2 |
0.959 |
IRS2 |
JAK1 |
0.959 |
IRS2 |
SOCS3 |
0.958 |
HRAS |
JAK3 |
0.958 |
JAK2 |
IL6R |
0.958 |
GHR |
STAT3 |
0.958 |
TYK2 |
PTPN11 |
0.958 |
CISH |
JAK3 |
0.957 |
STAT1 |
SOCS1 |
0.957 |
HRAS |
IRS1 |
0.957 |
TYK2 |
SOCS5 |
0.957 |
IL2RA |
JAK1 |
0.956 |
IRS1 |
KRAS |
0.955 |
SOCS1 |
IFNG |
0.955 |
JAK3 |
IRS2 |
0.955 |
TYK2 |
IL6ST |
0.955 |
HRAS |
LCK |
0.955 |
IL2RA |
LCK |
0.954 |
PTPN6 |
EPOR |
0.954 |
CUL2 |
SOCS5 |
0.954 |
JAK2 |
IL2 |
0.954 |
IL6R |
STAT1 |
0.954 |
SOCS5 |
STAT6 |
0.954 |
IL6 |
PTPN11 |
0.954 |
LCK |
RASA1 |
0.953 |
TYK2 |
IFNB1 |
0.953 |
STAT3 |
IL23A |
0.953 |
SH2B3 |
EPOR |
0.953 |
IL12RB1 |
STAT3 |
0.953 |
SOCS1 |
IL2RB |
0.953 |
HRAS |
JAK1 |
0.953 |
JAK2 |
IFNG |
0.953 |
PTPN11 |
LCK |
0.953 |
RNF7 |
VHL |
0.953 |
IRS2 |
IRS1 |
0.953 |
JAK3 |
IRS1 |
0.953 |
STAT3 |
IL2RB |
0.953 |
LCK |
SOCS1 |
0.952 |
IFNGR1 |
IFNAR1 |
0.952 |
SOCS2 |
SOCS3 |
0.952 |
JAK1 |
IFNG |
0.952 |
SOCS3 |
IFNAR1 |
0.952 |
STAT1 |
IL2RB |
0.95 |
CISH |
IL2 |
0.95 |
JAK3 |
LCK |
0.95 |
IFNGR1 |
PTPN11 |
0.95 |
TYK2 |
IL6R |
0.95 |
STAT5A |
IFNG |
0.95 |
JAK2 |
IL2RB |
0.949 |
GHR |
SOCS1 |
0.949 |
IL12RB1 |
JAK2 |
0.949 |
STAT1 |
IL23R |
0.949 |
JAK1 |
KRAS |
0.949 |
SOCS2 |
GH1 |
0.949 |
STAT5A |
STAT5B |
0.949 |
STAT2 |
STAT3 |
0.949 |
IFNB1 |
JAK1 |
0.949 |
PTPN6 |
IL2RB |
0.948 |
SOCS3 |
KRAS |
0.948 |
LCK |
SOCS3 |
0.948 |
PTPN6 |
IFNAR1 |
0.948 |
CISH |
LCK |
0.948 |
CUL2 |
CUL5 |
0.947 |
SOCS3 |
IL2RB |
0.947 |
CISH |
IL2RB |
0.947 |
STAT5A |
LEP |
0.946 |
HRAS |
SOCS3 |
0.946 |
PTK6 |
SOCS3 |
0.946 |
LCK |
KRAS |
0.946 |
CISH |
STAT1 |
0.946 |
LEP |
STAT5B |
0.946 |
PTPN11 |
LEP |
0.945 |
SOCS2 |
LCK |
0.945 |
STAT5A |
IL23R |
0.945 |
IFNGR1 |
SOCS3 |
0.945 |
IRS2 |
EPOR |
0.944 |
SOCS5 |
RNF7 |
0.944 |
HRAS |
SOCS1 |
0.944 |
JAK3 |
IL6R |
0.944 |
TYK2 |
JAK2 |
0.943 |
JAK3 |
JAK1 |
0.943 |
IL6 |
LEP |
0.943 |
IL2RA |
STAT1 |
0.943 |
JAK2 |
JAK1 |
0.943 |
SOCS1 |
RNF7 |
0.943 |
STAT1 |
STAT5B |
0.943 |
IL6ST |
STAT2 |
0.942 |
STAT1 |
IL23A |
0.942 |
IL6R |
STAT6 |
0.942 |
JAK3 |
KRAS |
0.942 |
STAT1 |
EPO |
0.941 |
PTPN11 |
IFNAR1 |
0.941 |
TYK2 |
JAK1 |
0.941 |
SH2B3 |
EPO |
0.94 |
KRAS |
IL2 |
0.94 |
SOCS2 |
CISH |
0.94 |
JAK3 |
STAT2 |
0.94 |
IL12RB1 |
STAT6 |
0.94 |
IL6 |
IFNG |
0.939 |
IL12RB1 |
STAT5A |
0.939 |
IFNB1 |
SOCS3 |
0.939 |
IL6R |
PTPN11 |
0.939 |
TYK2 |
JAK3 |
0.939 |
JAK2 |
IL2RA |
0.939 |
IL2RA |
SOCS1 |
0.938 |
IFNG |
IL2 |
0.938 |
IL6ST |
STAT5A |
0.938 |
GH1 |
STAT5B |
0.938 |
JAK2 |
GH1 |
0.937 |
HRAS |
IRS2 |
0.937 |
IRS2 |
PTPN11 |
0.937 |
IL23R |
STAT6 |
0.937 |
PTPN6 |
PTPN11 |
0.937 |
IL12RB1 |
JAK1 |
0.936 |
SOCS1 |
VHL |
0.936 |
IRS2 |
KRAS |
0.935 |
STAT1 |
EPOR |
0.935 |
SOCS2 |
CUL2 |
0.935 |
SOCS1 |
IFNGR2 |
0.935 |
SOCS3 |
IL23R |
0.934 |
STAT1 |
IFNGR2 |
0.933 |
JAK3 |
JAK2 |
0.933 |
CISH |
IL2RA |
0.933 |
STAT5A |
GH1 |
0.933 |
IL2RA |
SOCS3 |
0.931 |
STAT6 |
STAT3 |
0.931 |
STAT1 |
STAT6 |
0.931 |
TYK2 |
IL23A |
0.931 |
STAT6 |
IL23A |
0.931 |
GHR |
PTPN6 |
0.93 |
SOCS3 |
SOCS1 |
0.93 |
CISH |
STAT6 |
0.929 |
JAK3 |
EPOR |
0.929 |
PTPN6 |
STAT2 |
0.929 |
CISH |
GH1 |
0.929 |
PTPN6 |
SOCS3 |
0.929 |
GHR |
IRS2 |
0.929 |
IL12RB1 |
SOCS1 |
0.929 |
SOCS3 |
VHL |
0.928 |
JAK2 |
IL23A |
0.928 |
IL12RB1 |
SOCS3 |
0.928 |
CUL2 |
SOCS3 |
0.928 |
IL12RB1 |
LCK |
0.928 |
GHR |
STAT1 |
0.927 |
STAT5A |
STAT2 |
0.927 |
SH2B3 |
SOCS3 |
0.927 |
SOCS3 |
IL23A |
0.926 |
SOCS3 |
IFNGR2 |
0.926 |
PTPN6 |
IL2 |
0.926 |
CISH |
SOCS3 |
0.926 |
SOCS3 |
GH1 |
0.926 |
CISH |
STAT2 |
0.926 |
STAT2 |
STAT5B |
0.925 |
STAT5A |
IL23A |
0.925 |
JAK1 |
EPOR |
0.925 |
CISH |
VHL |
0.924 |
CISH |
SOCS5 |
0.924 |
SOCS1 |
SOCS5 |
0.924 |
LCK |
IRS1 |
0.923 |
IL6 |
IL23R |
0.922 |
HRAS |
IL2RA |
0.922 |
GH1 |
IRS1 |
0.921 |
IL6 |
IL2RA |
0.921 |
PTPN11 |
IFNG |
0.921 |
IL2RA |
KRAS |
0.92 |
PTPN6 |
IFNB1 |
0.919 |
IL2RA |
PTPN11 |
0.919 |
SOCS2 |
SOCS5 |
0.919 |
IRS1 |
IL2 |
0.919 |
PTPN6 |
EPO |
0.918 |
IRS2 |
EPO |
0.918 |
SOCS1 |
GH1 |
0.917 |
PTPN6 |
IFNG |
0.917 |
IFNAR1 |
IFNG |
0.917 |
GH1 |
STAT3 |
0.916 |
IRS2 |
LCK |
0.916 |
JAK2 |
LCK |
0.916 |
PTPN11 |
GH1 |
0.915 |
JAK1 |
LCK |
0.915 |
IRS2 |
IL2 |
0.915 |
HRAS |
IL2RB |
0.915 |
PTPN6 |
IFNGR1 |
0.915 |
PTK6 |
RASA1 |
0.914 |
PTPN11 |
IL2RB |
0.914 |
IRS2 |
SOCS1 |
0.914 |
SOCS2 |
VHL |
0.913 |
IFNB1 |
PTPN11 |
0.913 |
PTPN11 |
IFNGR2 |
0.912 |
IRS2 |
GH1 |
0.912 |
STAT1 |
GH1 |
0.911 |
SOCS2 |
IL2RB |
0.911 |
SOCS5 |
VHL |
0.911 |
IL2RA |
IRS1 |
0.91 |
JAK3 |
IFNAR1 |
0.91 |
JAK2 |
IFNAR1 |
0.909 |
TYK2 |
LCK |
0.908 |
STAT2 |
STAT6 |
0.908 |
PTPN6 |
IL2RA |
0.907 |
SH2B3 |
LCK |
0.905 |
KRAS |
IL2RB |
0.905 |
GH1 |
LEP |
0.905 |
STAT5A |
SOCS5 |
0.904 |
IL2RA |
IRS2 |
0.904 |
SOCS5 |
STAT5B |
0.904 |
PTPN6 |
IFNGR2 |
0.903 |
IRS1 |
IL2RB |
0.9 |
IRS2 |
IL2RB |
0.9 |
PTPN6 |
GH1 |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
3717 (JAK2) |
6921 (TCEB1) |
3559 (IL2RA) |
8453 (CUL2) |
8065 (CUL5) |
3569 (IL6) |
2056 (EPO) |
5781 (PTPN11) |
6923 (TCEB2) |
7297 (TYK2) |
9021 (SOCS3) |
3953 (LEPR) |
3718 (JAK3) |
3716 (JAK1) |
8835 (SOCS2) |
3459 (IFNGR1) |
6772 (STAT1) |
3456 (IFNB1) |
2690 (GHR) |
3558 (IL2) |
3265 (HRAS) |
149233 (IL23R) |
3952 (LEP) |
3570 (IL6R) |
6776 (STAT5A) |
3572 (IL6ST) |
6777 (STAT5B) |
9616 (RNF7) |
6773 (STAT2) |
1154 (CISH) |
8651 (SOCS1) |
5777 (PTPN6) |
3594 (IL12RB1) |
9655 (SOCS5) |
3932 (LCK) |
6774 (STAT3) |
5753 (PTK6) |
5921 (RASA1) |
3460 (IFNGR2) |
8660 (IRS2) |
3667 (IRS1) |
10019 (SH2B3) |
3845 (KRAS) |
3458 (IFNG) |
2688 (GH1) |
6778 (STAT6) |
3454 (IFNAR1) |
7428 (VHL) |
2057 (EPOR) |
3560 (IL2RB) |
51561 (IL23A) |
3717 (JAK2)
|
1.00
|
0.56
|
0.58
|
0.54
|
0.51
|
0.59
|
0.55
|
0.60
|
0.53
|
0.81
|
0.50
|
0.51
|
0.80
|
0.84
|
0.59
|
0.50
|
0.56
|
0.44
|
0.60
|
0.64
|
0.49
|
0.56
|
0.44
|
0.60
|
0.69
|
0.50
|
0.68
|
0.55
|
0.55
|
0.54
|
0.55
|
0.51
|
0.46
|
0.53
|
0.81
|
0.54
|
0.82
|
0.54
|
0.12
|
0.70
|
0.73
|
0.53
|
0.53
|
0.55
|
0.63
|
0.50
|
0.51
|
0.58
|
0.54
|
0.58
|
0.55
|
6921 (TCEB1)
|
0.56
|
1.00
|
0.52
|
0.83
|
0.71
|
0.68
|
0.60
|
0.48
|
0.70
|
0.58
|
0.49
|
0.51
|
0.58
|
0.54
|
0.59
|
0.58
|
0.53
|
0.49
|
0.61
|
0.56
|
0.50
|
0.56
|
0.53
|
0.57
|
0.52
|
0.46
|
0.55
|
0.77
|
0.65
|
0.59
|
0.49
|
0.46
|
0.43
|
0.57
|
0.62
|
0.47
|
0.65
|
0.53
|
0.12
|
0.56
|
0.56
|
0.64
|
0.69
|
0.72
|
0.67
|
0.49
|
0.58
|
0.91
|
0.63
|
0.52
|
0.70
|
3559 (IL2RA)
|
0.58
|
0.52
|
1.00
|
0.53
|
0.52
|
0.61
|
0.56
|
0.42
|
0.59
|
0.47
|
0.51
|
0.76
|
0.68
|
0.61
|
0.56
|
0.71
|
0.51
|
0.38
|
0.74
|
0.69
|
0.47
|
0.76
|
0.44
|
0.72
|
0.44
|
0.75
|
0.49
|
0.49
|
0.58
|
0.57
|
0.51
|
0.51
|
0.72
|
0.54
|
0.55
|
0.47
|
0.54
|
0.53
|
0.72
|
0.63
|
0.61
|
0.56
|
0.59
|
0.61
|
0.61
|
0.47
|
0.69
|
0.55
|
0.75
|
1.00
|
0.59
|
8453 (CUL2)
|
0.54
|
0.83
|
0.53
|
1.00
|
0.78
|
0.67
|
0.60
|
0.46
|
0.83
|
0.55
|
0.51
|
0.52
|
0.56
|
0.61
|
0.58
|
0.57
|
0.55
|
0.46
|
0.61
|
0.56
|
0.50
|
0.56
|
0.50
|
0.57
|
0.51
|
0.47
|
0.54
|
0.78
|
0.70
|
0.58
|
0.50
|
0.47
|
0.43
|
0.57
|
0.60
|
0.48
|
0.62
|
0.53
|
0.12
|
0.54
|
0.55
|
0.62
|
0.67
|
0.69
|
0.66
|
0.50
|
0.58
|
0.89
|
0.62
|
0.53
|
0.67
|
8065 (CUL5)
|
0.51
|
0.71
|
0.52
|
0.78
|
1.00
|
0.51
|
0.46
|
0.43
|
0.58
|
0.46
|
0.39
|
0.61
|
0.46
|
0.52
|
0.47
|
0.53
|
0.50
|
0.37
|
0.62
|
0.46
|
0.41
|
0.60
|
0.35
|
0.62
|
0.43
|
0.61
|
0.46
|
0.68
|
0.53
|
0.47
|
0.41
|
0.45
|
0.54
|
0.43
|
0.57
|
0.45
|
0.52
|
0.45
|
0.62
|
0.46
|
0.50
|
0.45
|
0.47
|
0.49
|
0.52
|
0.42
|
0.54
|
0.79
|
0.57
|
0.52
|
0.48
|
3569 (IL6)
|
0.59
|
0.68
|
0.61
|
0.67
|
0.51
|
1.00
|
0.77
|
0.49
|
0.75
|
0.60
|
0.60
|
0.58
|
0.61
|
0.57
|
0.67
|
0.67
|
0.56
|
0.67
|
0.65
|
0.79
|
0.58
|
0.67
|
0.66
|
0.70
|
0.56
|
0.57
|
0.57
|
0.60
|
0.70
|
0.65
|
0.57
|
0.53
|
0.54
|
0.66
|
0.61
|
0.51
|
0.69
|
0.63
|
0.12
|
0.58
|
0.58
|
0.72
|
0.75
|
0.87
|
0.81
|
0.56
|
0.66
|
0.65
|
0.69
|
0.61
|
0.78
|
2056 (EPO)
|
0.55
|
0.60
|
0.56
|
0.60
|
0.46
|
0.77
|
1.00
|
0.46
|
0.67
|
0.55
|
0.68
|
0.53
|
0.56
|
0.54
|
0.68
|
0.59
|
0.54
|
0.59
|
0.61
|
0.79
|
0.52
|
0.59
|
0.57
|
0.60
|
0.50
|
0.50
|
0.53
|
0.54
|
0.64
|
0.66
|
0.65
|
0.48
|
0.47
|
0.67
|
0.58
|
0.49
|
0.62
|
0.62
|
0.12
|
0.54
|
0.55
|
0.63
|
0.67
|
0.79
|
0.71
|
0.52
|
0.59
|
0.60
|
0.62
|
0.56
|
0.71
|
5781 (PTPN11)
|
0.60
|
0.48
|
0.42
|
0.46
|
0.43
|
0.49
|
0.46
|
1.00
|
0.46
|
0.53
|
0.40
|
0.43
|
0.51
|
0.52
|
0.52
|
0.42
|
0.48
|
0.37
|
0.54
|
0.45
|
0.43
|
0.45
|
0.35
|
0.50
|
0.49
|
0.42
|
0.51
|
0.47
|
0.48
|
0.47
|
0.47
|
0.73
|
0.35
|
0.46
|
0.80
|
0.47
|
0.58
|
0.51
|
0.12
|
0.70
|
0.78
|
0.46
|
0.46
|
0.47
|
0.50
|
0.42
|
0.44
|
0.52
|
0.45
|
0.42
|
0.46
|
6923 (TCEB2)
|
0.53
|
0.70
|
0.59
|
0.83
|
0.58
|
0.75
|
0.67
|
0.46
|
1.00
|
0.56
|
0.58
|
0.56
|
0.59
|
0.62
|
0.65
|
0.68
|
0.57
|
0.48
|
0.64
|
0.61
|
0.55
|
0.61
|
0.60
|
0.60
|
0.53
|
0.49
|
0.56
|
0.58
|
0.79
|
0.65
|
0.54
|
0.50
|
0.47
|
0.65
|
0.58
|
0.50
|
0.64
|
0.57
|
0.12
|
0.55
|
0.56
|
0.74
|
0.80
|
0.82
|
0.73
|
0.54
|
0.67
|
0.67
|
0.71
|
0.59
|
0.80
|
7297 (TYK2)
|
0.81
|
0.58
|
0.47
|
0.55
|
0.46
|
0.60
|
0.55
|
0.53
|
0.56
|
1.00
|
0.44
|
0.47
|
0.78
|
0.86
|
0.63
|
0.48
|
0.52
|
0.44
|
0.56
|
0.52
|
0.45
|
0.52
|
0.48
|
0.56
|
0.74
|
0.46
|
0.70
|
0.54
|
0.56
|
0.52
|
0.45
|
0.42
|
0.41
|
0.49
|
0.75
|
0.46
|
0.92
|
0.49
|
0.12
|
0.63
|
0.61
|
0.52
|
0.56
|
0.58
|
0.70
|
0.46
|
0.50
|
0.59
|
0.53
|
0.47
|
0.59
|
9021 (SOCS3)
|
0.50
|
0.49
|
0.51
|
0.51
|
0.39
|
0.60
|
0.68
|
0.40
|
0.58
|
0.44
|
1.00
|
0.47
|
0.51
|
0.48
|
0.78
|
0.48
|
0.51
|
0.37
|
0.57
|
0.64
|
0.44
|
0.51
|
0.44
|
0.54
|
0.41
|
0.44
|
0.47
|
0.47
|
0.57
|
0.82
|
0.90
|
0.41
|
0.39
|
0.82
|
0.54
|
0.46
|
0.52
|
0.54
|
0.12
|
0.49
|
0.52
|
0.53
|
0.58
|
0.60
|
0.60
|
0.45
|
0.50
|
0.53
|
0.54
|
0.51
|
0.58
|
3953 (LEPR)
|
0.51
|
0.51
|
0.76
|
0.52
|
0.61
|
0.58
|
0.53
|
0.43
|
0.56
|
0.47
|
0.47
|
1.00
|
0.49
|
0.47
|
0.53
|
0.79
|
0.53
|
0.37
|
0.92
|
0.52
|
0.48
|
0.87
|
0.41
|
0.81
|
0.46
|
0.84
|
0.49
|
0.49
|
0.59
|
0.54
|
0.48
|
0.59
|
0.83
|
0.51
|
0.55
|
0.51
|
0.56
|
0.50
|
0.82
|
0.48
|
0.51
|
0.54
|
0.56
|
0.57
|
0.58
|
0.51
|
0.78
|
0.53
|
0.86
|
0.76
|
0.56
|
3718 (JAK3)
|
0.80
|
0.58
|
0.68
|
0.56
|
0.46
|
0.61
|
0.56
|
0.51
|
0.59
|
0.78
|
0.51
|
0.49
|
1.00
|
0.91
|
0.56
|
0.51
|
0.52
|
0.40
|
0.58
|
0.69
|
0.47
|
0.53
|
0.44
|
0.55
|
0.66
|
0.45
|
0.64
|
0.54
|
0.58
|
0.57
|
0.51
|
0.44
|
0.40
|
0.54
|
0.74
|
0.50
|
0.82
|
0.52
|
0.12
|
0.77
|
0.69
|
0.55
|
0.59
|
0.61
|
0.61
|
0.55
|
0.52
|
0.61
|
0.56
|
0.68
|
0.59
|
3716 (JAK1)
|
0.84
|
0.54
|
0.61
|
0.61
|
0.52
|
0.57
|
0.54
|
0.52
|
0.62
|
0.86
|
0.48
|
0.47
|
0.91
|
1.00
|
0.61
|
0.48
|
0.53
|
0.40
|
0.55
|
0.64
|
0.46
|
0.51
|
0.42
|
0.56
|
0.67
|
0.46
|
0.65
|
0.52
|
0.58
|
0.53
|
0.49
|
0.43
|
0.40
|
0.50
|
0.75
|
0.49
|
0.81
|
0.51
|
0.12
|
0.71
|
0.67
|
0.51
|
0.53
|
0.54
|
0.64
|
0.52
|
0.49
|
0.59
|
0.51
|
0.61
|
0.55
|
8835 (SOCS2)
|
0.59
|
0.59
|
0.56
|
0.58
|
0.47
|
0.67
|
0.68
|
0.52
|
0.65
|
0.63
|
0.78
|
0.53
|
0.56
|
0.61
|
1.00
|
0.58
|
0.54
|
0.48
|
0.60
|
0.66
|
0.52
|
0.58
|
0.56
|
0.59
|
0.50
|
0.50
|
0.53
|
0.54
|
0.63
|
0.78
|
0.79
|
0.49
|
0.46
|
0.79
|
0.58
|
0.49
|
0.61
|
0.60
|
0.12
|
0.54
|
0.65
|
0.64
|
0.65
|
0.67
|
0.75
|
0.52
|
0.58
|
0.59
|
0.61
|
0.56
|
0.67
|
3459 (IFNGR1)
|
0.50
|
0.58
|
0.71
|
0.57
|
0.53
|
0.67
|
0.59
|
0.42
|
0.68
|
0.48
|
0.48
|
0.79
|
0.51
|
0.48
|
0.58
|
1.00
|
0.52
|
0.42
|
0.77
|
0.55
|
0.48
|
0.80
|
0.52
|
0.72
|
0.45
|
0.74
|
0.50
|
0.51
|
0.64
|
0.57
|
0.48
|
0.53
|
0.74
|
0.55
|
0.56
|
0.48
|
0.57
|
0.52
|
1.00
|
0.49
|
0.53
|
0.63
|
0.68
|
0.70
|
0.66
|
0.49
|
0.84
|
0.58
|
0.85
|
0.71
|
0.68
|
6772 (STAT1)
|
0.56
|
0.53
|
0.51
|
0.55
|
0.50
|
0.56
|
0.54
|
0.48
|
0.57
|
0.52
|
0.51
|
0.53
|
0.52
|
0.53
|
0.54
|
0.52
|
1.00
|
0.39
|
0.60
|
0.53
|
0.51
|
0.53
|
0.41
|
0.59
|
0.69
|
0.52
|
0.73
|
0.51
|
0.75
|
0.55
|
0.51
|
0.50
|
0.42
|
0.53
|
0.57
|
0.83
|
0.56
|
0.53
|
0.12
|
0.51
|
0.53
|
0.54
|
0.56
|
0.55
|
0.57
|
0.81
|
0.53
|
0.57
|
0.56
|
0.51
|
0.55
|
3456 (IFNB1)
|
0.44
|
0.49
|
0.38
|
0.46
|
0.37
|
0.67
|
0.59
|
0.37
|
0.48
|
0.44
|
0.37
|
0.37
|
0.40
|
0.40
|
0.48
|
0.42
|
0.39
|
1.00
|
0.42
|
0.55
|
0.36
|
0.43
|
0.52
|
0.45
|
0.37
|
0.36
|
0.41
|
0.43
|
0.45
|
0.42
|
0.38
|
0.33
|
0.34
|
0.44
|
0.49
|
0.34
|
0.51
|
0.43
|
0.08
|
0.45
|
0.45
|
0.48
|
0.50
|
0.67
|
0.59
|
0.35
|
0.41
|
0.48
|
0.44
|
0.38
|
0.55
|
2690 (GHR)
|
0.60
|
0.61
|
0.74
|
0.61
|
0.62
|
0.65
|
0.61
|
0.54
|
0.64
|
0.56
|
0.57
|
0.92
|
0.58
|
0.55
|
0.60
|
0.77
|
0.60
|
0.42
|
1.00
|
0.59
|
0.56
|
0.83
|
0.46
|
0.82
|
0.55
|
0.86
|
0.57
|
0.57
|
0.67
|
0.61
|
0.60
|
0.66
|
0.76
|
0.63
|
0.62
|
0.60
|
0.63
|
0.57
|
0.82
|
0.56
|
0.60
|
0.64
|
0.64
|
0.65
|
0.64
|
0.58
|
0.76
|
0.61
|
0.83
|
0.74
|
0.64
|
3558 (IL2)
|
0.64
|
0.56
|
0.69
|
0.56
|
0.46
|
0.79
|
0.79
|
0.45
|
0.61
|
0.52
|
0.64
|
0.52
|
0.69
|
0.64
|
0.66
|
0.55
|
0.53
|
0.55
|
0.59
|
1.00
|
0.50
|
0.59
|
0.53
|
0.63
|
0.49
|
0.51
|
0.51
|
0.52
|
0.60
|
0.65
|
0.64
|
0.48
|
0.48
|
0.64
|
0.58
|
0.48
|
0.60
|
0.63
|
0.12
|
0.65
|
0.63
|
0.58
|
0.61
|
0.70
|
0.70
|
0.50
|
0.56
|
0.57
|
0.58
|
0.69
|
0.63
|
3265 (HRAS)
|
0.49
|
0.50
|
0.47
|
0.50
|
0.41
|
0.58
|
0.52
|
0.43
|
0.55
|
0.45
|
0.44
|
0.48
|
0.47
|
0.46
|
0.52
|
0.48
|
0.51
|
0.36
|
0.56
|
0.50
|
1.00
|
0.51
|
0.41
|
0.54
|
0.43
|
0.45
|
0.47
|
0.48
|
0.55
|
0.50
|
0.45
|
0.44
|
0.39
|
0.49
|
0.56
|
0.47
|
0.51
|
0.63
|
0.12
|
0.46
|
0.50
|
0.52
|
0.55
|
0.57
|
0.58
|
0.46
|
0.50
|
0.53
|
0.53
|
0.47
|
0.55
|
149233 (IL23R)
|
0.56
|
0.56
|
0.76
|
0.56
|
0.60
|
0.67
|
0.59
|
0.45
|
0.61
|
0.52
|
0.51
|
0.87
|
0.53
|
0.51
|
0.58
|
0.80
|
0.53
|
0.43
|
0.83
|
0.59
|
0.51
|
1.00
|
0.47
|
0.87
|
0.49
|
0.87
|
0.52
|
0.52
|
0.60
|
0.57
|
0.51
|
0.58
|
0.98
|
0.55
|
0.56
|
0.50
|
0.57
|
0.54
|
0.82
|
0.51
|
0.53
|
0.59
|
0.61
|
0.63
|
0.64
|
0.51
|
0.79
|
0.57
|
0.83
|
0.76
|
0.64
|
3952 (LEP)
|
0.44
|
0.53
|
0.44
|
0.50
|
0.35
|
0.66
|
0.57
|
0.35
|
0.60
|
0.48
|
0.44
|
0.41
|
0.44
|
0.42
|
0.56
|
0.52
|
0.41
|
0.52
|
0.46
|
0.53
|
0.41
|
0.47
|
1.00
|
0.47
|
0.40
|
0.37
|
0.43
|
0.42
|
0.53
|
0.48
|
0.43
|
0.37
|
0.36
|
0.52
|
0.47
|
0.35
|
0.55
|
0.47
|
0.08
|
0.43
|
0.44
|
0.59
|
0.60
|
0.68
|
0.76
|
0.39
|
0.49
|
0.47
|
0.53
|
0.44
|
0.65
|
3570 (IL6R)
|
0.60
|
0.57
|
0.72
|
0.57
|
0.62
|
0.70
|
0.60
|
0.50
|
0.60
|
0.56
|
0.54
|
0.81
|
0.55
|
0.56
|
0.59
|
0.72
|
0.59
|
0.45
|
0.82
|
0.63
|
0.54
|
0.87
|
0.47
|
1.00
|
0.53
|
0.92
|
0.54
|
0.55
|
0.61
|
0.58
|
0.54
|
0.60
|
0.84
|
0.57
|
0.60
|
0.55
|
0.60
|
0.58
|
0.82
|
0.54
|
0.56
|
0.59
|
0.59
|
0.60
|
0.67
|
0.54
|
0.72
|
0.59
|
0.76
|
0.72
|
0.66
|
6776 (STAT5A)
|
0.69
|
0.52
|
0.44
|
0.51
|
0.43
|
0.56
|
0.50
|
0.49
|
0.53
|
0.74
|
0.41
|
0.46
|
0.66
|
0.67
|
0.50
|
0.45
|
0.69
|
0.37
|
0.55
|
0.49
|
0.43
|
0.49
|
0.40
|
0.53
|
1.00
|
0.43
|
0.89
|
0.50
|
0.81
|
0.53
|
0.43
|
0.40
|
0.38
|
0.47
|
0.69
|
0.68
|
0.78
|
0.47
|
0.12
|
0.57
|
0.57
|
0.50
|
0.53
|
0.55
|
0.57
|
0.78
|
0.48
|
0.56
|
0.51
|
0.44
|
0.53
|
3572 (IL6ST)
|
0.50
|
0.46
|
0.75
|
0.47
|
0.61
|
0.57
|
0.50
|
0.42
|
0.49
|
0.46
|
0.44
|
0.84
|
0.45
|
0.46
|
0.50
|
0.74
|
0.52
|
0.36
|
0.86
|
0.51
|
0.45
|
0.87
|
0.37
|
0.92
|
0.43
|
1.00
|
0.46
|
0.46
|
0.51
|
0.50
|
0.45
|
0.56
|
0.84
|
0.46
|
0.52
|
0.50
|
0.50
|
0.48
|
0.82
|
0.45
|
0.49
|
0.48
|
0.49
|
0.50
|
0.54
|
0.46
|
0.74
|
0.48
|
0.79
|
0.75
|
0.52
|
6777 (STAT5B)
|
0.68
|
0.55
|
0.49
|
0.54
|
0.46
|
0.57
|
0.53
|
0.51
|
0.56
|
0.70
|
0.47
|
0.49
|
0.64
|
0.65
|
0.53
|
0.50
|
0.73
|
0.41
|
0.57
|
0.51
|
0.47
|
0.52
|
0.43
|
0.54
|
0.89
|
0.46
|
1.00
|
0.52
|
0.75
|
0.55
|
0.47
|
0.45
|
0.40
|
0.50
|
0.68
|
0.70
|
0.74
|
0.50
|
0.12
|
0.58
|
0.58
|
0.53
|
0.62
|
0.57
|
0.58
|
0.74
|
0.51
|
0.57
|
0.53
|
0.49
|
0.56
|
9616 (RNF7)
|
0.55
|
0.77
|
0.49
|
0.78
|
0.68
|
0.60
|
0.54
|
0.47
|
0.58
|
0.54
|
0.47
|
0.49
|
0.54
|
0.52
|
0.54
|
0.51
|
0.51
|
0.43
|
0.57
|
0.52
|
0.48
|
0.52
|
0.42
|
0.55
|
0.50
|
0.46
|
0.52
|
1.00
|
0.58
|
0.54
|
0.47
|
0.45
|
0.40
|
0.51
|
0.60
|
0.47
|
0.60
|
0.50
|
0.12
|
0.53
|
0.55
|
0.55
|
0.58
|
0.59
|
0.60
|
0.48
|
0.52
|
0.82
|
0.55
|
0.49
|
0.58
|
6773 (STAT2)
|
0.55
|
0.65
|
0.58
|
0.70
|
0.53
|
0.70
|
0.64
|
0.48
|
0.79
|
0.56
|
0.57
|
0.59
|
0.58
|
0.58
|
0.63
|
0.64
|
0.75
|
0.45
|
0.67
|
0.60
|
0.55
|
0.60
|
0.53
|
0.61
|
0.81
|
0.51
|
0.75
|
0.58
|
1.00
|
0.65
|
0.55
|
0.51
|
0.47
|
0.62
|
0.60
|
0.71
|
0.66
|
0.57
|
0.12
|
0.55
|
0.56
|
0.68
|
0.72
|
0.74
|
0.69
|
0.83
|
0.64
|
0.65
|
0.72
|
0.58
|
0.72
|
1154 (CISH)
|
0.54
|
0.59
|
0.57
|
0.58
|
0.47
|
0.65
|
0.66
|
0.47
|
0.65
|
0.52
|
0.82
|
0.54
|
0.57
|
0.53
|
0.78
|
0.57
|
0.55
|
0.42
|
0.61
|
0.65
|
0.50
|
0.57
|
0.48
|
0.58
|
0.53
|
0.50
|
0.55
|
0.54
|
0.65
|
1.00
|
0.75
|
0.47
|
0.45
|
0.83
|
0.58
|
0.51
|
0.59
|
0.57
|
0.21
|
0.55
|
0.56
|
0.60
|
0.65
|
0.67
|
0.64
|
0.54
|
0.58
|
0.60
|
0.61
|
0.57
|
0.65
|
8651 (SOCS1)
|
0.55
|
0.49
|
0.51
|
0.50
|
0.41
|
0.57
|
0.65
|
0.47
|
0.54
|
0.45
|
0.90
|
0.48
|
0.51
|
0.49
|
0.79
|
0.48
|
0.51
|
0.38
|
0.60
|
0.64
|
0.45
|
0.51
|
0.43
|
0.54
|
0.43
|
0.45
|
0.47
|
0.47
|
0.55
|
0.75
|
1.00
|
0.50
|
0.39
|
0.79
|
0.58
|
0.49
|
0.53
|
0.56
|
0.12
|
0.50
|
0.60
|
0.53
|
0.54
|
0.56
|
0.57
|
0.46
|
0.50
|
0.53
|
0.52
|
0.51
|
0.54
|
5777 (PTPN6)
|
0.51
|
0.46
|
0.51
|
0.47
|
0.45
|
0.53
|
0.48
|
0.73
|
0.50
|
0.42
|
0.41
|
0.59
|
0.44
|
0.43
|
0.49
|
0.53
|
0.50
|
0.33
|
0.66
|
0.48
|
0.44
|
0.58
|
0.37
|
0.60
|
0.40
|
0.56
|
0.45
|
0.45
|
0.51
|
0.47
|
0.50
|
1.00
|
0.50
|
0.49
|
0.66
|
0.48
|
0.48
|
0.53
|
0.43
|
0.44
|
0.57
|
0.50
|
0.50
|
0.51
|
0.54
|
0.44
|
0.53
|
0.51
|
0.57
|
0.51
|
0.50
|
3594 (IL12RB1)
|
0.46
|
0.43
|
0.72
|
0.43
|
0.54
|
0.54
|
0.47
|
0.35
|
0.47
|
0.41
|
0.39
|
0.83
|
0.40
|
0.40
|
0.46
|
0.74
|
0.42
|
0.34
|
0.76
|
0.48
|
0.39
|
0.98
|
0.36
|
0.84
|
0.38
|
0.84
|
0.40
|
0.40
|
0.47
|
0.45
|
0.39
|
0.50
|
1.00
|
0.42
|
0.45
|
0.40
|
0.45
|
0.42
|
0.82
|
0.40
|
0.42
|
0.46
|
0.47
|
0.48
|
0.52
|
0.39
|
0.74
|
0.44
|
0.77
|
0.72
|
0.51
|
9655 (SOCS5)
|
0.53
|
0.57
|
0.54
|
0.57
|
0.43
|
0.66
|
0.67
|
0.46
|
0.65
|
0.49
|
0.82
|
0.51
|
0.54
|
0.50
|
0.79
|
0.55
|
0.53
|
0.44
|
0.63
|
0.64
|
0.49
|
0.55
|
0.52
|
0.57
|
0.47
|
0.46
|
0.50
|
0.51
|
0.62
|
0.83
|
0.79
|
0.49
|
0.42
|
1.00
|
0.57
|
0.49
|
0.58
|
0.57
|
0.12
|
0.52
|
0.59
|
0.72
|
0.65
|
0.67
|
0.65
|
0.49
|
0.56
|
0.59
|
0.60
|
0.54
|
0.65
|
3932 (LCK)
|
0.81
|
0.62
|
0.55
|
0.60
|
0.57
|
0.61
|
0.58
|
0.80
|
0.58
|
0.75
|
0.54
|
0.55
|
0.74
|
0.75
|
0.58
|
0.56
|
0.57
|
0.49
|
0.62
|
0.58
|
0.56
|
0.56
|
0.47
|
0.60
|
0.69
|
0.52
|
0.68
|
0.60
|
0.60
|
0.58
|
0.58
|
0.66
|
0.45
|
0.57
|
1.00
|
0.57
|
0.81
|
0.61
|
0.12
|
0.72
|
0.77
|
0.58
|
0.58
|
0.60
|
0.62
|
0.58
|
0.56
|
0.65
|
0.59
|
0.55
|
0.59
|
6774 (STAT3)
|
0.54
|
0.47
|
0.47
|
0.48
|
0.45
|
0.51
|
0.49
|
0.47
|
0.50
|
0.46
|
0.46
|
0.51
|
0.50
|
0.49
|
0.49
|
0.48
|
0.83
|
0.34
|
0.60
|
0.48
|
0.47
|
0.50
|
0.35
|
0.55
|
0.68
|
0.50
|
0.70
|
0.47
|
0.71
|
0.51
|
0.49
|
0.48
|
0.40
|
0.49
|
0.57
|
1.00
|
0.51
|
0.47
|
0.20
|
0.46
|
0.51
|
0.49
|
0.51
|
0.50
|
0.52
|
0.84
|
0.48
|
0.52
|
0.52
|
0.47
|
0.50
|
5753 (PTK6)
|
0.82
|
0.65
|
0.54
|
0.62
|
0.52
|
0.69
|
0.62
|
0.58
|
0.64
|
0.92
|
0.52
|
0.56
|
0.82
|
0.81
|
0.61
|
0.57
|
0.56
|
0.51
|
0.63
|
0.60
|
0.51
|
0.57
|
0.55
|
0.60
|
0.78
|
0.50
|
0.74
|
0.60
|
0.66
|
0.59
|
0.53
|
0.48
|
0.45
|
0.58
|
0.81
|
0.51
|
1.00
|
0.56
|
0.12
|
0.68
|
0.66
|
0.62
|
0.64
|
0.68
|
0.70
|
0.54
|
0.58
|
0.65
|
0.65
|
0.54
|
0.66
|
5921 (RASA1)
|
0.54
|
0.53
|
0.53
|
0.53
|
0.45
|
0.63
|
0.62
|
0.51
|
0.57
|
0.49
|
0.54
|
0.50
|
0.52
|
0.51
|
0.60
|
0.52
|
0.53
|
0.43
|
0.57
|
0.63
|
0.63
|
0.54
|
0.47
|
0.58
|
0.47
|
0.48
|
0.50
|
0.50
|
0.57
|
0.57
|
0.56
|
0.53
|
0.42
|
0.57
|
0.61
|
0.47
|
0.56
|
1.00
|
0.12
|
0.52
|
0.59
|
0.55
|
0.57
|
0.60
|
0.64
|
0.49
|
0.53
|
0.56
|
0.55
|
0.53
|
0.58
|
3460 (IFNGR2)
|
0.12
|
0.12
|
0.72
|
0.12
|
0.62
|
0.12
|
0.12
|
0.12
|
0.12
|
0.12
|
0.12
|
0.82
|
0.12
|
0.12
|
0.12
|
1.00
|
0.12
|
0.08
|
0.82
|
0.12
|
0.12
|
0.82
|
0.08
|
0.82
|
0.12
|
0.82
|
0.12
|
0.12
|
0.12
|
0.21
|
0.12
|
0.43
|
0.82
|
0.12
|
0.12
|
0.20
|
0.12
|
0.12
|
1.00
|
0.12
|
0.14
|
0.14
|
0.12
|
0.12
|
0.12
|
0.12
|
0.80
|
0.12
|
0.72
|
0.72
|
0.12
|
8660 (IRS2)
|
0.70
|
0.56
|
0.63
|
0.54
|
0.46
|
0.58
|
0.54
|
0.70
|
0.55
|
0.63
|
0.49
|
0.48
|
0.77
|
0.71
|
0.54
|
0.49
|
0.51
|
0.45
|
0.56
|
0.65
|
0.46
|
0.51
|
0.43
|
0.54
|
0.57
|
0.45
|
0.58
|
0.53
|
0.55
|
0.55
|
0.50
|
0.44
|
0.40
|
0.52
|
0.72
|
0.46
|
0.68
|
0.52
|
0.12
|
1.00
|
0.86
|
0.52
|
0.55
|
0.57
|
0.58
|
0.47
|
0.50
|
0.57
|
0.53
|
0.63
|
0.55
|
3667 (IRS1)
|
0.73
|
0.56
|
0.61
|
0.55
|
0.50
|
0.58
|
0.55
|
0.78
|
0.56
|
0.61
|
0.52
|
0.51
|
0.69
|
0.67
|
0.65
|
0.53
|
0.53
|
0.45
|
0.60
|
0.63
|
0.50
|
0.53
|
0.44
|
0.56
|
0.57
|
0.49
|
0.58
|
0.55
|
0.56
|
0.56
|
0.60
|
0.57
|
0.42
|
0.59
|
0.77
|
0.51
|
0.66
|
0.59
|
0.14
|
0.86
|
1.00
|
0.64
|
0.56
|
0.57
|
0.58
|
0.50
|
0.53
|
0.58
|
0.55
|
0.61
|
0.56
|
10019 (SH2B3)
|
0.53
|
0.64
|
0.56
|
0.62
|
0.45
|
0.72
|
0.63
|
0.46
|
0.74
|
0.52
|
0.53
|
0.54
|
0.55
|
0.51
|
0.64
|
0.63
|
0.54
|
0.48
|
0.64
|
0.58
|
0.52
|
0.59
|
0.59
|
0.59
|
0.50
|
0.48
|
0.53
|
0.55
|
0.68
|
0.60
|
0.53
|
0.50
|
0.46
|
0.72
|
0.58
|
0.49
|
0.62
|
0.55
|
0.14
|
0.52
|
0.64
|
1.00
|
0.74
|
0.77
|
0.70
|
0.51
|
0.62
|
0.62
|
0.67
|
0.56
|
0.74
|
3845 (KRAS)
|
0.53
|
0.69
|
0.59
|
0.67
|
0.47
|
0.75
|
0.67
|
0.46
|
0.80
|
0.56
|
0.58
|
0.56
|
0.59
|
0.53
|
0.65
|
0.68
|
0.56
|
0.50
|
0.64
|
0.61
|
0.55
|
0.61
|
0.60
|
0.59
|
0.53
|
0.49
|
0.62
|
0.58
|
0.72
|
0.65
|
0.54
|
0.50
|
0.47
|
0.65
|
0.58
|
0.51
|
0.64
|
0.57
|
0.12
|
0.55
|
0.56
|
0.74
|
1.00
|
0.82
|
0.73
|
0.54
|
0.66
|
0.65
|
0.71
|
0.59
|
0.80
|
3458 (IFNG)
|
0.55
|
0.72
|
0.61
|
0.69
|
0.49
|
0.87
|
0.79
|
0.47
|
0.82
|
0.58
|
0.60
|
0.57
|
0.61
|
0.54
|
0.67
|
0.70
|
0.55
|
0.67
|
0.65
|
0.70
|
0.57
|
0.63
|
0.68
|
0.60
|
0.55
|
0.50
|
0.57
|
0.59
|
0.74
|
0.67
|
0.56
|
0.51
|
0.48
|
0.67
|
0.60
|
0.50
|
0.68
|
0.60
|
0.12
|
0.57
|
0.57
|
0.77
|
0.82
|
1.00
|
0.75
|
0.55
|
0.68
|
0.66
|
0.73
|
0.61
|
0.82
|
2688 (GH1)
|
0.63
|
0.67
|
0.61
|
0.66
|
0.52
|
0.81
|
0.71
|
0.50
|
0.73
|
0.70
|
0.60
|
0.58
|
0.61
|
0.64
|
0.75
|
0.66
|
0.57
|
0.59
|
0.64
|
0.70
|
0.58
|
0.64
|
0.76
|
0.67
|
0.57
|
0.54
|
0.58
|
0.60
|
0.69
|
0.64
|
0.57
|
0.54
|
0.52
|
0.65
|
0.62
|
0.52
|
0.70
|
0.64
|
0.12
|
0.58
|
0.58
|
0.70
|
0.73
|
0.75
|
1.00
|
0.56
|
0.66
|
0.65
|
0.68
|
0.61
|
0.79
|
6778 (STAT6)
|
0.50
|
0.49
|
0.47
|
0.50
|
0.42
|
0.56
|
0.52
|
0.42
|
0.54
|
0.46
|
0.45
|
0.51
|
0.55
|
0.52
|
0.52
|
0.49
|
0.81
|
0.35
|
0.58
|
0.50
|
0.46
|
0.51
|
0.39
|
0.54
|
0.78
|
0.46
|
0.74
|
0.48
|
0.83
|
0.54
|
0.46
|
0.44
|
0.39
|
0.49
|
0.58
|
0.84
|
0.54
|
0.49
|
0.12
|
0.47
|
0.50
|
0.51
|
0.54
|
0.55
|
0.56
|
1.00
|
0.50
|
0.53
|
0.56
|
0.47
|
0.54
|
3454 (IFNAR1)
|
0.51
|
0.58
|
0.69
|
0.58
|
0.54
|
0.66
|
0.59
|
0.44
|
0.67
|
0.50
|
0.50
|
0.78
|
0.52
|
0.49
|
0.58
|
0.84
|
0.53
|
0.41
|
0.76
|
0.56
|
0.50
|
0.79
|
0.49
|
0.72
|
0.48
|
0.74
|
0.51
|
0.52
|
0.64
|
0.58
|
0.50
|
0.53
|
0.74
|
0.56
|
0.56
|
0.48
|
0.58
|
0.53
|
0.80
|
0.50
|
0.53
|
0.62
|
0.66
|
0.68
|
0.66
|
0.50
|
1.00
|
0.58
|
0.81
|
0.69
|
0.67
|
7428 (VHL)
|
0.58
|
0.91
|
0.55
|
0.89
|
0.79
|
0.65
|
0.60
|
0.52
|
0.67
|
0.59
|
0.53
|
0.53
|
0.61
|
0.59
|
0.59
|
0.58
|
0.57
|
0.48
|
0.61
|
0.57
|
0.53
|
0.57
|
0.47
|
0.59
|
0.56
|
0.48
|
0.57
|
0.82
|
0.65
|
0.60
|
0.53
|
0.51
|
0.44
|
0.59
|
0.65
|
0.52
|
0.65
|
0.56
|
0.12
|
0.57
|
0.58
|
0.62
|
0.65
|
0.66
|
0.65
|
0.53
|
0.58
|
1.00
|
0.61
|
0.55
|
0.65
|
2057 (EPOR)
|
0.54
|
0.63
|
0.75
|
0.62
|
0.57
|
0.69
|
0.62
|
0.45
|
0.71
|
0.53
|
0.54
|
0.86
|
0.56
|
0.51
|
0.61
|
0.85
|
0.56
|
0.44
|
0.83
|
0.58
|
0.53
|
0.83
|
0.53
|
0.76
|
0.51
|
0.79
|
0.53
|
0.55
|
0.72
|
0.61
|
0.52
|
0.57
|
0.77
|
0.60
|
0.59
|
0.52
|
0.65
|
0.55
|
0.72
|
0.53
|
0.55
|
0.67
|
0.71
|
0.73
|
0.68
|
0.56
|
0.81
|
0.61
|
1.00
|
0.75
|
0.71
|
3560 (IL2RB)
|
0.58
|
0.52
|
1.00
|
0.53
|
0.52
|
0.61
|
0.56
|
0.42
|
0.59
|
0.47
|
0.51
|
0.76
|
0.68
|
0.61
|
0.56
|
0.71
|
0.51
|
0.38
|
0.74
|
0.69
|
0.47
|
0.76
|
0.44
|
0.72
|
0.44
|
0.75
|
0.49
|
0.49
|
0.58
|
0.57
|
0.51
|
0.51
|
0.72
|
0.54
|
0.55
|
0.47
|
0.54
|
0.53
|
0.72
|
0.63
|
0.61
|
0.56
|
0.59
|
0.61
|
0.61
|
0.47
|
0.69
|
0.55
|
0.75
|
1.00
|
0.59
|
51561 (IL23A)
|
0.55
|
0.70
|
0.59
|
0.67
|
0.48
|
0.78
|
0.71
|
0.46
|
0.80
|
0.59
|
0.58
|
0.56
|
0.59
|
0.55
|
0.67
|
0.68
|
0.55
|
0.55
|
0.64
|
0.63
|
0.55
|
0.64
|
0.65
|
0.66
|
0.53
|
0.52
|
0.56
|
0.58
|
0.72
|
0.65
|
0.54
|
0.50
|
0.51
|
0.65
|
0.59
|
0.50
|
0.66
|
0.58
|
0.12
|
0.55
|
0.56
|
0.74
|
0.80
|
0.82
|
0.79
|
0.54
|
0.67
|
0.65
|
0.71
|
0.59
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
SOCS3 |
Toad |
Liver |
- |
3464 m |
33 day |
upregulated |
3.297111176 |
RNA-seq |
Tibetan Plateau |
Asiatic toad |
1 |
Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - |
28673260 |
SOCS3 |
Toad |
Heart |
- |
3464 m |
33 day |
upregulated |
4.860165488 |
RNA-seq |
Tibetan Plateau |
Asiatic toad |
1 |
Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - |
28673260 |
SOCS3 |
Toad |
Heart |
- |
3464 m |
33 day |
downregulated |
-2.261172901 |
RNA-seq |
Tibetan Plateau |
Asiatic toad |
1 |
Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - |
28673260 |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
9021 |
GO:0001932 |
regulation of protein phosphorylation |
GOTERM_BP_DIRECT |
9021 |
GO:0016567 |
protein ubiquitination |
GOTERM_BP_DIRECT |
9021 |
GO:0060674 |
placenta blood vessel development |
GOTERM_BP_DIRECT |
9021 |
GO:0005622 |
intracellular |
GOTERM_CC_DIRECT |
9021 |
GO:0042512 |
negative regulation of tyrosine phosphorylation of Stat1 protein |
GOTERM_BP_DIRECT |
9021 |
GO:0060707 |
trophoblast giant cell differentiation |
GOTERM_BP_DIRECT |
9021 |
GO:0004860 |
phospholipase inhibitor activity |
GOTERM_MF_DIRECT |
9021 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
9021 |
GO:0005829 |
cytosol |
GOTERM_CC_DIRECT |
9021 |
GO:0046426 |
negative regulation of JAK-STAT cascade |
GOTERM_BP_DIRECT |
9021 |
GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
GOTERM_BP_DIRECT |
9021 |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
GOTERM_BP_DIRECT |
9021 |
GO:0005737 |
cytoplasm |
GOTERM_CC_DIRECT |
9021 |
GO:0043066 |
negative regulation of apoptotic process |
GOTERM_BP_DIRECT |
9021 |
GO:0050728 |
negative regulation of inflammatory response |
GOTERM_BP_DIRECT |
9021 |
GO:0042518 |
negative regulation of tyrosine phosphorylation of Stat3 protein |
GOTERM_BP_DIRECT |
9021 |
GO:0006469 |
negative regulation of protein kinase activity |
GOTERM_BP_DIRECT |
9021 |
GO:0019221 |
cytokine-mediated signaling pathway |
GOTERM_BP_DIRECT |
9021 |
GO:0060708 |
spongiotrophoblast differentiation |
GOTERM_BP_DIRECT |
9021 |
GO:0060334 |
regulation of interferon-gamma-mediated signaling pathway |
GOTERM_BP_DIRECT |
9021 |
GO:0007259 |
JAK-STAT cascade |
GOTERM_BP_DIRECT |
9021 |
GO:0045597 |
positive regulation of cell differentiation |
GOTERM_BP_DIRECT |
9021 |
GO:0040008 |
regulation of growth |
GOTERM_BP_DIRECT |
9021 |
GO:0060670 |
branching involved in labyrinthine layer morphogenesis |
GOTERM_BP_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
9021 |
hsa04120 |
Ubiquitin mediated proteolysis |
9021 |
hsa04380 |
Osteoclast differentiation |
9021 |
hsa04630 |
Jak-STAT signaling pathway |
9021 |
hsa04668 |
TNF signaling pathway |
9021 |
hsa04930 |
Type II diabetes mellitus |
9021 |
hsa04931 |
Insulin resistance |
9021 |
hsa04932 |
Non-alcoholic fatty liver disease |
9021 |
hsa04920 |
Adipocytokine signaling pathway |
9021 |
hsa04910 |
Insulin signaling pathway |
9021 |
hsa04917 |
Prolactin signaling pathway |
9021 |
hsa05168 |
Herpes simplex infection |
9021 |
hsa05164 |
Influenza A |
9021 |
hsa05160 |
Hepatitis C |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
SOCS3 |
9021 |
Endometrial Neoplasms |
C0014170 |
Neoplastic Process |
0.3 |
0.487 |
0.724 |
group |
SOCS3 |
9021 |
Liver carcinoma |
C2239176 |
Neoplastic Process |
0.4 |
0.487 |
0.724 |
disease |
SOCS3 |
9021 |
Endometrial Carcinoma |
C0476089 |
Neoplastic Process |
0.3 |
0.487 |
0.724 |
disease |
SOCS3 |
9021 |
Liver Dysfunction |
C0086565 |
Finding |
0.3 |
0.487 |
0.724 |
phenotype |
SOCS3 |
9021 |
Atherogenesis |
C1563937 |
Pathologic Function |
0.3 |
0.487 |
0.724 |
phenotype |
SOCS3 |
9021 |
Liver diseases |
C0023895 |
Disease or Syndrome |
0.3 |
0.487 |
0.724 |
group |
SOCS3 |
9021 |
Atherosclerosis |
C0004153 |
Disease or Syndrome |
0.32 |
0.487 |
0.724 |
disease |
SOCS3 |
9021 |
Myocardial Ischemia |
C0151744 |
Disease or Syndrome |
0.3 |
0.487 |
0.724 |
disease |
Association with Drug
Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |
SOCS3 |
9021 |
ANTISENSE OLIGONUCLEOTIDES |
None |
None |
None |