Potassium calcium-activated channel subfamily M alpha 1

AltitudeomicsDB
Protein Official symbol KCNMA1
Aliases KCNMA1 KCNMA SLO
Chromosomal Location 10
Length 1236
Uniprot ID Q12791
EC number None
Protein family Information(Pfam) PF03493;PF00520;
PDB id 2K44;3MT5;3NAF;6V22;6V35;6V38;6V3G;
InterPro ID IPR024939;IPR005821;IPR003929;IPR036291;IPR027359;
dbSNP rs137853333 rs886039469

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
KCNMA1 KCNMB1 0.9890000000000001
KCNMB3 KCNMA1 0.986
PRKACG PRKACB 0.981
PRKACB PRKACA 0.98
KCNMA1 KCNMB4 0.966
KCNMA1 KCNN4 0.961
KCNN3 KCNMB4 0.9590000000000001
KCNN1 KCNMA1 0.955
KCNN2 KCNMA1 0.9470000000000001
KCNN3 KCNMA1 0.946
PRKACG PRKACA 0.943
KCNN4 KCNMB4 0.9390000000000001
KCNN2 KCNMB4 0.925
KCNMA1 PRKG2 0.9229999999999999
ENSG00000275163 KCNMA1 0.9159999999999999
KCNN1 KCNU1 0.914
KCNMB3 PRKG2 0.912
PRKG2 KCNMB4 0.91
KCNMB1 PRKG2 0.907
PRKG1 CACNA1C 0.9059999999999999
KCNU1 KCNMB1 0.905
CACNA1D CACNA1C 0.905
CACNA1F CACNA1S 0.904
CACNA1S CACNA1D 0.903
KCNN2 KCNU1 0.903
CACNA1F CACNA1C 0.903
CACNA1S CACNA1C 0.902
CACNA1F CACNA1D 0.902
KCNU1 KCNN4 0.898
PRKG1 KCNMA1 0.892
KCNU1 KCNMB4 0.8909999999999999
KCNN1 KCNMB1 0.89
KCNN3 KCNU1 0.887
KCNMB1 KCNN4 0.884
PRKACA CACNA1C 0.878
PRKACG KCNMA1 0.877
KCNMA1 CACNA1C 0.877
KCNN2 KCNMB1 0.8759999999999999
PRKACA KCNMA1 0.873
PRKACB KCNMA1 0.873
KCNA3 KCNN4 0.865
KCNMB1 KCNMB4 0.857
KCNN3 KCNMB1 0.853
CACNA1F PRKG1 0.853
KCNMB3 KCNN4 0.85
CACNA1D KCNMA1 0.847
KCNN3 KCNMB3 0.846
ENSG00000275163 KCNU1 0.846
CTNNAL1 KCNMA1 0.835
KCNN1 KCNMB4 0.8320000000000001
KCNMB3 KCNMB1 0.8320000000000001
KCNN1 KCNMB3 0.8270000000000001
LRRC26 KCNMA1 0.825
KCNU1 KCNMB3 0.8220000000000001
KCNMB3 KCNMB4 0.821
ENSG00000275163 KCNMB4 0.821
PRKG1 CACNA1D 0.821
PRKACG CACNA1C 0.818
ENSG00000275163 KCNN3 0.8170000000000001
PRKACA CACNA1D 0.816
CACNA1H CACNA1C 0.816
KCNU1 PRKG1 0.815
KCNN1 KCNN4 0.815
KCNN3 KCNN4 0.815
PRKACB CACNA1C 0.8140000000000001
KCNN2 KCNN4 0.813
KCNU1 KCNMA1 0.812
ENSG00000275163 KCNMB3 0.812
PRKG1 KCNMB4 0.812
KCNN2 KCNMB3 0.812
CACNA1S KCNMA1 0.812
ENSG00000275163 KCNMB1 0.8109999999999999
PRKG1 KCNMB1 0.81
KCNN3 KCNN1 0.81
KCNN1 KCNN2 0.809
PRKACG CACNA1D 0.809
PRKACB CACNA1D 0.809
PRKG1 PRKG2 0.8079999999999999
PRKG1 CACNA1S 0.8079999999999999
CACNA1C PRKG2 0.8079999999999999
ENSG00000275163 KCNN2 0.8079999999999999
ENSG00000275163 KCNN1 0.807
KCNN3 KCNN2 0.807
CACNA1H CACNA1D 0.8059999999999999
CACNA1S PRKG2 0.8059999999999999
ENSG00000275163 KCNN4 0.804
CACNA1D PRKG2 0.8029999999999999
CACNA1F PRKG2 0.8029999999999999
PRKG1 KCNMB3 0.802
CSN3 KCNN4 0.8
ENSG00000275163 PRKG1 0.8
CACNA1S CACNA1H 0.795
CACNA1F CACNA1H 0.794
DMD CTNNAL1 0.789
CACNA1F KCNMA1 0.7759999999999999
KCNMB1 CACNA1C 0.7659999999999999
KCNMA1 KCNH1 0.759
KCNA2 KCNMA1 0.747
KCNN3 CSN3 0.732
CSN3 KCNMA1 0.728
ATP1B1 KCNMA1 0.727
LRRC26 KCNMB1 0.718
DMD KCNMA1 0.7140000000000001
KCNU1 LRRC26 0.7120000000000001
CACNA1H KCNMA1 0.7120000000000001
KCNN2 CSN3 0.7070000000000001
KCNA3 KCNMA1 0.705
KCNU1 PRKACA 0.703
KCNU1 PRKACG 0.703
KCNU1 PRKACB 0.703
KCNN1 CSN3 0.7
Gene Ontology Semantic Similarity
Download Tab separated file
# 3778 (KCNMA1) 27094 (KCNMB3) 5568 (PRKACG) 5567 (PRKACB) 3782 (KCNN3) 3780 (KCNN1) 3781 (KCNN2) 3783 (KCNN4) 5593 (PRKG2) 3779 (KCNMB1) 5592 (PRKG1) 157855 (KCNU1) 776 (CACNA1D) 778 (CACNA1F) 779 (CACNA1S) 5566 (PRKACA) 3738 (KCNA3) 8727 (CTNNAL1) 389816 (LRRC26) 8912 (CACNA1H) 775 (CACNA1C) 1448 (CSN3) 1756 (DMD) 3737 (KCNA2) 481 (ATP1B1) 27345 (KCNMB4) 3756 (KCNH1)
3778 (KCNMA1) 1.00 0.61 0.08 0.37 0.81 0.85 0.85 0.88 0.08 0.61 0.37 0.74 0.66 0.47 0.74 0.43 0.61 1.00 0.44 0.70 0.72 0.50 0.60 0.91 0.47 0.82 0.78
27094 (KCNMB3) 0.61 1.00 0.08 0.13 0.56 0.66 0.44 0.57 0.09 1.00 0.30 0.71 0.39 0.42 0.41 0.13 0.52 0.21 0.57 0.42 0.38 0.27 0.16 0.60 0.20 0.84 0.39
5568 (PRKACG) 0.08 0.08 1.00 0.56 0.08 0.07 0.09 0.08 0.84 0.08 0.64 0.03 0.05 0.03 0.09 0.57 0.04 0.13 0.12 0.07 0.07 0.20 0.10 0.08 0.09 0.10 0.09
5567 (PRKACB) 0.37 0.13 0.56 1.00 0.33 0.30 0.46 0.40 0.50 0.13 0.69 0.05 0.25 0.04 0.37 0.81 0.06 1.00 0.42 0.30 0.37 0.48 0.51 0.34 0.54 0.38 0.39
3782 (KCNN3) 0.81 0.56 0.08 0.33 1.00 0.99 0.82 0.88 0.09 0.56 0.34 0.67 0.51 0.40 0.63 0.39 0.50 0.82 0.47 0.59 0.64 0.53 0.52 0.77 0.39 0.74 0.64
3780 (KCNN1) 0.85 0.66 0.07 0.30 0.99 1.00 0.85 0.91 0.08 0.66 0.30 0.74 0.53 0.44 0.63 0.36 0.56 0.82 0.39 0.60 0.65 0.45 0.47 0.80 0.39 0.79 0.66
3781 (KCNN2) 0.85 0.44 0.09 0.46 0.82 0.85 1.00 0.88 0.09 0.44 0.49 0.47 0.62 0.27 0.70 0.52 0.34 1.00 0.58 0.62 0.76 0.61 0.62 0.80 0.52 0.80 0.72
3783 (KCNN4) 0.88 0.57 0.08 0.40 0.88 0.91 0.88 1.00 0.09 0.57 0.41 0.64 0.58 0.38 0.70 0.45 0.48 1.00 0.48 0.65 0.71 0.53 0.56 0.87 0.50 0.83 0.74
5593 (PRKG2) 0.08 0.09 0.84 0.50 0.09 0.08 0.09 0.09 1.00 0.09 0.67 0.04 0.06 0.03 0.09 0.52 0.04 0.14 0.13 0.08 0.08 0.21 0.11 0.08 0.10 0.11 0.10
3779 (KCNMB1) 0.61 1.00 0.08 0.13 0.56 0.66 0.44 0.57 0.09 1.00 0.30 0.71 0.39 0.42 0.41 0.13 0.52 0.21 0.57 0.42 0.38 0.27 0.16 0.60 0.20 0.84 0.39
5592 (PRKG1) 0.37 0.30 0.64 0.69 0.34 0.30 0.49 0.41 0.67 0.30 1.00 0.06 0.25 0.05 0.37 0.77 0.07 1.00 0.59 0.30 0.38 0.55 0.55 0.33 0.40 0.52 0.40
157855 (KCNU1) 0.74 0.71 0.03 0.05 0.67 0.74 0.47 0.64 0.04 0.71 0.06 1.00 0.52 0.65 0.55 0.05 0.84 0.07 0.07 0.59 0.48 0.11 0.06 0.83 0.16 0.60 0.58
776 (CACNA1D) 0.66 0.39 0.05 0.25 0.51 0.53 0.62 0.58 0.06 0.39 0.25 0.52 1.00 0.74 0.87 0.29 0.53 0.69 0.30 0.76 0.91 0.34 0.42 0.67 0.33 0.53 0.60
778 (CACNA1F) 0.47 0.42 0.03 0.04 0.40 0.44 0.27 0.38 0.03 0.42 0.05 0.65 0.74 1.00 0.81 0.04 0.70 0.07 0.06 0.71 0.67 0.10 0.05 0.58 0.10 0.35 0.42
779 (CACNA1S) 0.74 0.41 0.09 0.37 0.63 0.63 0.70 0.70 0.09 0.41 0.37 0.55 0.87 0.81 1.00 0.44 0.58 1.00 0.47 0.86 0.93 0.54 0.58 0.77 0.44 0.64 0.72
5566 (PRKACA) 0.43 0.13 0.57 0.81 0.39 0.36 0.52 0.45 0.52 0.13 0.77 0.05 0.29 0.04 0.44 1.00 0.06 1.00 0.50 0.36 0.42 0.56 0.57 0.41 0.42 0.45 0.46
3738 (KCNA3) 0.61 0.52 0.04 0.06 0.50 0.56 0.34 0.48 0.04 0.52 0.07 0.84 0.53 0.70 0.58 0.06 1.00 0.09 0.08 0.59 0.48 0.12 0.07 0.76 0.13 0.44 0.54
8727 (CTNNAL1) 1.00 0.21 0.13 1.00 0.82 0.82 1.00 1.00 0.14 0.21 1.00 0.07 0.69 0.07 1.00 1.00 0.09 1.00 1.00 0.82 1.00 1.00 1.00 1.00 1.00 1.00 1.00
389816 (LRRC26) 0.44 0.57 0.12 0.42 0.47 0.39 0.58 0.48 0.13 0.57 0.59 0.07 0.30 0.06 0.47 0.50 0.08 1.00 1.00 0.39 0.43 0.72 0.65 0.40 0.44 0.81 0.51
8912 (CACNA1H) 0.70 0.42 0.07 0.30 0.59 0.60 0.62 0.65 0.08 0.42 0.30 0.59 0.76 0.71 0.86 0.36 0.59 0.82 0.39 1.00 0.80 0.44 0.47 0.75 0.38 0.59 0.66
775 (CACNA1C) 0.72 0.38 0.07 0.37 0.64 0.65 0.76 0.71 0.08 0.38 0.38 0.48 0.91 0.67 0.93 0.42 0.48 1.00 0.43 0.80 1.00 0.48 0.52 0.74 0.45 0.63 0.70
1448 (CSN3) 0.50 0.27 0.20 0.48 0.53 0.45 0.61 0.53 0.21 0.27 0.55 0.11 0.34 0.10 0.54 0.56 0.12 1.00 0.72 0.44 0.48 1.00 0.70 0.47 0.47 0.59 0.57
1756 (DMD) 0.60 0.16 0.10 0.51 0.52 0.47 0.62 0.56 0.11 0.16 0.55 0.06 0.42 0.05 0.58 0.57 0.07 1.00 0.65 0.47 0.52 0.70 1.00 0.53 0.51 0.59 0.60
3737 (KCNA2) 0.91 0.60 0.08 0.34 0.77 0.80 0.80 0.87 0.08 0.60 0.33 0.83 0.67 0.58 0.77 0.41 0.76 1.00 0.40 0.75 0.74 0.47 0.53 1.00 0.47 0.77 0.86
481 (ATP1B1) 0.47 0.20 0.09 0.54 0.39 0.39 0.52 0.50 0.10 0.20 0.40 0.16 0.33 0.10 0.44 0.42 0.13 1.00 0.44 0.38 0.45 0.47 0.51 0.47 1.00 0.46 0.46
27345 (KCNMB4) 0.82 0.84 0.10 0.38 0.74 0.79 0.80 0.83 0.11 0.84 0.52 0.60 0.53 0.35 0.64 0.45 0.44 1.00 0.81 0.59 0.63 0.59 0.59 0.77 0.46 1.00 0.65
3756 (KCNH1) 0.78 0.39 0.09 0.39 0.64 0.66 0.72 0.74 0.10 0.39 0.40 0.58 0.60 0.42 0.72 0.46 0.54 1.00 0.51 0.66 0.70 0.57 0.60 0.86 0.46 0.65 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
KCNMA1 Human Blood - 3250 m 4 day upregulated 2.45 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
MITF 4286 KCNMA1 3778 Repression 10328874 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT005943 hsa-miR-211-5p Homo sapiens KCNMA1 3778 Homo sapiens Microarray//LacZ reporter assay Functional MTI 21072171
MIRT440404 hsa-miR-218-5p Homo sapiens KCNMA1 3778 Homo sapiens HITS-CLIP Functional MTI (Weak) 23212916
MIRT732797 hsa-miR-17-5p Homo sapiens KCNMA1 3778 Homo sapiens AGO2 Immunoprecipitation//Immunofluorescence//Microarray//qRT-PCR Functional MTI (Weak) 27245839
Gene Ontology
ID GO ID GO Term GO Type
3778 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
3778 GO:0030007 cellular potassium ion homeostasis GOTERM_BP_DIRECT
3778 GO:0034765 regulation of ion transmembrane transport GOTERM_BP_DIRECT
3778 GO:0006970 response to osmotic stress GOTERM_BP_DIRECT
3778 GO:0034465 response to carbon monoxide GOTERM_BP_DIRECT
3778 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
3778 GO:0042391 regulation of membrane potential GOTERM_BP_DIRECT
3778 GO:0006813 potassium ion transport GOTERM_BP_DIRECT
3778 GO:0045794 negative regulation of cell volume GOTERM_BP_DIRECT
3778 GO:0060083 smooth muscle contraction involved in micturition GOTERM_BP_DIRECT
3778 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
3778 GO:0008076 voltage-gated potassium channel complex GOTERM_CC_DIRECT
3778 GO:0015269 glycerol channel activity GOTERM_MF_DIRECT
3778 GO:0016324 apical plasma membrane GOTERM_CC_DIRECT
3778 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3778 GO:0051592 response to calcium ion GOTERM_BP_DIRECT
3778 GO:0005901 caveola GOTERM_CC_DIRECT
3778 GO:0060073 micturition GOTERM_BP_DIRECT
3778 GO:0060072 D-glucose transmembrane transporter activity GOTERM_MF_DIRECT
3778 GO:0016020 membrane GOTERM_CC_DIRECT
3778 GO:0003779 actin binding GOTERM_MF_DIRECT
3778 GO:0071805 potassium ion transmembrane transport GOTERM_BP_DIRECT
3778 GO:0005515 protein binding GOTERM_MF_DIRECT
3778 GO:0046872 metal ion binding GOTERM_MF_DIRECT
3778 GO:0005886 plasma membrane GOTERM_CC_DIRECT
3778 GO:0005249 calcium channel regulator activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3778 hsa04022 cGMP-PKG signaling pathway
3778 hsa04270 Vascular smooth muscle contraction
3778 hsa04911 Insulin secretion
3778 hsa04972 Pancreatic secretion
3778 hsa04924 Renin secretion
3778 hsa04970 Salivary secretion
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
KCNMA1 3778 Osteopenia C0029453 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Renal Cell Carcinoma C0007134 Neoplastic Process 0.3 0.572 0.586 disease
KCNMA1 3778 Metabolic Bone Disorder C0005944 Disease or Syndrome 0.3 0.572 0.586 group
KCNMA1 3778 Diaphragmatic Hernia C0019284 Anatomical Abnormality 0.3 0.572 0.586 phenotype
KCNMA1 3778 Pulmonary Hypertension C0020542 Pathologic Function 0.3 0.572 0.586 phenotype
KCNMA1 3778 Grand Mal Status Epilepticus C0311335 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Status Epilepticus C0038220 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Obesity, Morbid C0028756 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Status Epilepticus, Subclinical C0751522 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Collecting Duct Carcinoma of the Kidney C1266044 Neoplastic Process 0.3 0.572 0.586 disease
KCNMA1 3778 Papillary Renal Cell Carcinoma C1306837 Neoplastic Process 0.3 0.572 0.586 disease
KCNMA1 3778 Obesity C0028754 Disease or Syndrome 0.41 0.572 0.586 disease
KCNMA1 3778 Conventional (Clear Cell) Renal Cell Carcinoma C0279702 Neoplastic Process 0.3 0.572 0.586 disease
KCNMA1 3778 Simple Partial Status Epilepticus C0751524 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Sarcomatoid Renal Cell Carcinoma C1266043 Neoplastic Process 0.3 0.572 0.586 disease
KCNMA1 3778 Chromophobe Renal Cell Carcinoma C1266042 Neoplastic Process 0.3 0.572 0.586 disease
KCNMA1 3778 Autistic Disorder C0004352 Mental or Behavioral Dysfunction 0.3 0.572 0.586 group
KCNMA1 3778 Petit mal status C0270823 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Complex Partial Status Epilepticus C0393734 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Weight Gain C0043094 Finding 0.3 0.572 0.586 phenotype
KCNMA1 3778 Neonatal Death C0410916 Finding 0.3 0.572 0.586 disease
KCNMA1 3778 Perinatal death C0701826 Finding 0.3 0.572 0.586 phenotype
KCNMA1 3778 Non-Convulsive Status Epilepticus C0751523 Disease or Syndrome 0.3 0.572 0.586 disease
KCNMA1 3778 Growth Disorders C0018273 Pathologic Function 0.3 0.572 0.586 group
KCNMA1 3778 Generalized Epilepsy and Paroxysmal Dyskinesia C1836173 Disease or Syndrome 0.72 0.572 0.586 disease
KCNMA1 3778 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.572 0.586 group
KCNMA1 3778 Epileptic encephalopathy C0543888 Disease or Syndrome 0.3 0.572 0.586 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
KCNMA1 3778 17β-ESTRADIOL None None activator
KCNMA1 3778 ANDOLAST ANDOLAST CHEMBL119549 activator
KCNMA1 3778 BMS-223131 BMS-223131 CHEMBL222460 activator
KCNMA1 3778 CHARYBDOTOXIN None None channel blocker
KCNMA1 3778 CHLORZOXAZONE CHLORZOXAZONE CHEMBL1371 None
KCNMA1 3778 CHLORZOXAZONE CHLORZOXAZONE CHEMBL1371 None
KCNMA1 3778 CHLOROTHIAZIDE CHLOROTHIAZIDE CHEMBL842 None
KCNMA1 3778 CROMOGLICATE None None None
KCNMA1 3778 CROMOGLICATE None None None
KCNMA1 3778 ENFLURANE ENFLURANE CHEMBL1257 None
KCNMA1 3778 ENFLURANE ENFLURANE CHEMBL1257 None
KCNMA1 3778 FLINDOKALNER FLINDOKALNER CHEMBL266510 activator
KCNMA1 3778 FLINDOKALNER FLINDOKALNER CHEMBL266510 None
KCNMA1 3778 IBERIOTOXIN None None channel blocker
KCNMA1 3778 NS004 None None activator
KCNMA1 3778 NS1643 None None activator
KCNMA1 3778 NS1619 CHEMBL1290115 CHEMBL1290115 activator
KCNMA1 3778 SLOTOXIN None None channel blocker
KCNMA1 3778 TETRAETHYLAMMONIUM None None channel blocker
KCNMA1 3778 TRICHLORMETHIAZIDE TRICHLORMETHIAZIDE CHEMBL1054 None
KCNMA1 3778 TRICHLORMETHIAZIDE TRICHLORMETHIAZIDE CHEMBL1054 None