Protein-lysine 6-oxidase

AltitudeomicsDB
Protein Official symbol LOX
Aliases LOX
Chromosomal Location  5
Length 417
Uniprot ID P28300
EC number 1.4.3.13
Protein family Information(Pfam) PF01186;
PDB id None
InterPro ID IPR001695;IPR019828;
dbSNP rs752839330 rs767855588 rs1800449 rs886040967 rs886040965 rs876657852

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ELN FBLN5 0.99
ELN LOX 0.99
FBLN5 LOXL1 0.983
MFAP2 ELN 0.974
ELN LOXL1 0.973
FBLN5 LOX 0.969
LOXL2 ELN 0.966
MFAP2 FBLN5 0.96
BMP1 LOX 0.959
ELN LOXL3 0.958
MFAP2 LOXL1 0.956
ELN LOXL4 0.956
LOXL2 BMP1 0.953
BMP1 LOXL3 0.953
BMP1 LOXL1 0.95
MFAP5 ELN 0.948
MFAP2 LOX 0.948
LOX PCOLCE 0.941
LOXL1 PCOLCE 0.939
LOXL2 LOXL1 0.936
MFAP5 FBLN5 0.935
BMP1 LOXL4 0.934
LOXL1 LOX 0.934
MFAP5 LOX 0.933
LOXL2 LOX 0.933
LOXL1 LOXL4 0.928
FBLN5 LOXL4 0.927
LOXL2 FBLN5 0.927
LOXL2 PCOLCE 0.926
LOXL3 LOXL1 0.925
FBLN5 LOXL3 0.925
LOXL4 TLL1 0.925
LOXL2 TLL1 0.922
MFAP2 MFAP5 0.922
LOX TLL1 0.921
MFAP5 LOXL1 0.92
LOXL2 MFAP2 0.92
LOXL4 LOX 0.92
LOXL1 TLL1 0.919
LOXL3 LOX 0.917
TLL2 PCOLCE 0.913
TLL2 LOXL4 0.909
LOXL2 MFAP5 0.907
LOXL2 LOXL3 0.907
LOXL3 PCOLCE 0.907
LOXL2 LOXL4 0.907
LOXL2 TLL2 0.906
LOXL3 LOXL4 0.906
TLL2 LOX 0.905
LOXL4 PCOLCE 0.905
TLL2 LOXL1 0.903
MFAP2 LOXL4 0.902
MFAP2 LOXL3 0.902
LOXL3 TLL1 0.902
MFAP5 LOXL4 0.902
MFAP5 LOXL3 0.902
TLL2 LOXL3 0.901
Gene Ontology Semantic Similarity
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# 2006 (ELN) 10516 (FBLN5) 4237 (MFAP2) 4017 (LOXL2) 649 (BMP1) 8076 (MFAP5) 4015 (LOX) 4016 (LOXL1) 84695 (LOXL3) 84171 (LOXL4) 7093 (TLL2) 5118 (PCOLCE) 7092 (TLL1)
2006 (ELN) 1.00 0.83 1.00 0.47 0.43 1.00 0.52 0.16 0.53 0.52 0.12 0.73 0.12
10516 (FBLN5) 0.83 1.00 0.71 0.53 0.52 0.71 0.61 0.16 0.60 0.61 0.12 0.66 0.10
4237 (MFAP2) 1.00 0.71 1.00 0.34 0.26 1.00 0.26 0.16 0.26 0.26 0.12 1.00 0.13
4017 (LOXL2) 0.47 0.53 0.34 1.00 0.45 0.34 0.69 1.00 0.83 0.69 0.16 0.47 0.12
649 (BMP1) 0.43 0.52 0.26 0.45 1.00 0.26 0.49 0.28 0.50 0.49 1.00 0.44 0.70
8076 (MFAP5) 1.00 0.71 1.00 0.34 0.26 1.00 0.26 0.16 0.26 0.26 0.12 1.00 0.13
4015 (LOX) 0.52 0.61 0.26 0.69 0.49 0.26 1.00 1.00 0.86 1.00 0.16 0.50 0.15
4016 (LOXL1) 0.16 0.16 0.16 1.00 0.28 0.16 1.00 1.00 1.00 1.00 0.16 0.16 0.16
84695 (LOXL3) 0.53 0.60 0.26 0.83 0.50 0.26 0.86 1.00 1.00 0.86 0.16 0.52 0.13
84171 (LOXL4) 0.52 0.61 0.26 0.69 0.49 0.26 1.00 1.00 0.86 1.00 0.16 0.50 0.15
7093 (TLL2) 0.12 0.12 0.12 0.16 1.00 0.12 0.16 0.16 0.16 0.16 1.00 0.12 1.00
5118 (PCOLCE) 0.73 0.66 1.00 0.47 0.44 1.00 0.50 0.16 0.52 0.50 0.12 1.00 0.10
7092 (TLL1) 0.12 0.10 0.13 0.12 0.70 0.13 0.15 0.16 0.13 0.15 1.00 0.10 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
LOX Mice Blood 8% Oxygen 7600 m 24 hours upregulated 31.2 RT-qPCR Western US C57BL/6 mice –3.9 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
LOX Mice Blood 8% Oxygen 7600 m 24 hours upregulated 3.9 RT-qPCR Western US C57BL/6 mice –3.9 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
FOS 2353 LOX 4015 distal 22955619 TRANSFAC
GATA2 2624 LOX 4015 distal 22955619 TRANSFAC
JUN 3725 LOX 4015 distal 22955619 TRANSFAC
GATA3 2625 LOX 4015 Activation 23846700 TRUSST
HIF1A 3091 LOX 4015 Unknown 19259613 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT018405 hsa-miR-335-5p Homo sapiens LOX 4015 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT437550 hsa-miR-29a-3p Homo sapiens LOX 4015 Homo sapiens Luciferase reporter assay Functional MTI 22745231
MIRT437556 hsa-miR-29b-3p Homo sapiens LOX 4015 Homo sapiens qRT-PCR Functional MTI (Weak) 25744716
MIRT437556 hsa-miR-29b-3p Homo sapiens LOX 4015 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 23354167
MIRT437556 hsa-miR-29b-3p Homo sapiens LOX 4015 Homo sapiens Luciferase reporter assay Functional MTI 22745231
MIRT437571 hsa-miR-767-5p Homo sapiens LOX 4015 Homo sapiens Luciferase reporter assay Functional MTI 22745231
MIRT437561 hsa-miR-29c-3p Homo sapiens LOX 4015 Homo sapiens Luciferase reporter assay Functional MTI 22745231
MIRT438051 hsa-miR-200b-3p Homo sapiens LOX 4015 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 23975428
MIRT442618 hsa-miR-4743-3p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT442622 hsa-miR-142-3p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT442626 hsa-miR-548e-5p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT442624 hsa-miR-3120-5p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT442623 hsa-miR-6830-3p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT442620 hsa-miR-511-5p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT442619 hsa-miR-3591-5p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT442621 hsa-miR-6888-3p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT442625 hsa-miR-4280 Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT731147 hsa-miR-30a-5p Homo sapiens LOX 4015 Homo sapiens Western blot//Luciferase reporter assay//Immunohistochemistry Functional MTI 25488748
MIRT761778 hsa-miR-1271-5p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT763003 hsa-miR-182-5p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT769463 hsa-miR-4470 Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT769935 hsa-miR-4517 Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT774726 hsa-miR-5583-3p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT782596 hsa-miR-889-3p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT782998 hsa-miR-9-5p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT783005 hsa-miR-96-5p Homo sapiens LOX 4015 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
Gene Ontology
ID GO ID GO Term GO Type
4015 GO:0048545 response to steroid hormone GOTERM_BP_DIRECT
4015 GO:0004720 non-membrane spanning protein tyrosine kinase activity GOTERM_MF_DIRECT
4015 GO:0005507 copper ion binding GOTERM_MF_DIRECT
4015 GO:0005581 collagen trimer GOTERM_CC_DIRECT
4015 GO:0006464 cellular protein modification process GOTERM_BP_DIRECT
4015 GO:0005615 extracellular space GOTERM_CC_DIRECT
4015 GO:0005576 extracellular region GOTERM_CC_DIRECT
4015 GO:0030199 collagen fibril organization GOTERM_BP_DIRECT
4015 GO:0035904 aorta development GOTERM_BP_DIRECT
4015 GO:0016641 oxidoreductase activity GOTERM_MF_DIRECT
4015 GO:0007507 heart development GOTERM_BP_DIRECT
4015 GO:0030198 extracellular matrix organization GOTERM_BP_DIRECT
4015 GO:0042493 response to drug GOTERM_BP_DIRECT
4015 GO:0030324 lung development GOTERM_BP_DIRECT
4015 GO:0042060 wound healing GOTERM_BP_DIRECT
4015 GO:0005578 proteinaceous extracellular matrix GOTERM_CC_DIRECT
4015 GO:0048251 elastic fiber assembly GOTERM_BP_DIRECT
4015 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
4015 GO:0005515 protein binding GOTERM_MF_DIRECT
4015 GO:0005634 nucleus GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
LOX 4015 Marfan Syndrome C0024796 Disease or Syndrome 0.31 0.488 0.793 disease
LOX 4015 Hepatitis B C0019163 Disease or Syndrome 0.3 0.488 0.793 disease
LOX 4015 Liver Cirrhosis C0023890 Disease or Syndrome 0.3 0.488 0.793 disease
LOX 4015 Oral Submucous Fibrosis C0029172 Disease or Syndrome 0.32 0.488 0.793 disease
LOX 4015 Aortic Valve Insufficiency C0003504 Disease or Syndrome 0.4 0.488 0.793 disease
LOX 4015 Primary biliary cirrhosis C0008312 Disease or Syndrome 0.31 0.488 0.793 disease
LOX 4015 Biliary cirrhosis C0023892 Disease or Syndrome 0.3 0.488 0.793 disease
LOX 4015 Biliary Cirrhosis, Secondary C0238065 Disease or Syndrome 0.3 0.488 0.793 disease
LOX 4015 Fibrosis, Liver C0239946 Disease or Syndrome 0.31 0.488 0.793 disease
LOX 4015 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.488 0.793 disease
LOX 4015 Prenatal Injuries C0086468 Injury or Poisoning 0.3 0.488 0.793 group
LOX 4015 Pulmonary Hypertension C0020542 Pathologic Function 0.3 0.488 0.793 phenotype
LOX 4015 Hepatitis C C0019196 Disease or Syndrome 0.3 0.488 0.793 disease
LOX 4015 Hepatic Form of Wilson Disease C1527352 Disease or Syndrome 0.3 0.488 0.793 disease
LOX 4015 Osteosarcoma C0029463 Neoplastic Process 0.33 0.488 0.793 disease
LOX 4015 Hepatolenticular Degeneration C0019202 Disease or Syndrome 0.32 0.488 0.793 disease
LOX 4015 AORTIC ANEURYSM, FAMILIAL THORACIC 10 C4284414 Disease or Syndrome 0.6 0.488 0.793 disease
LOX 4015 Ehlers-Danlos Syndrome C0013720 Disease or Syndrome 0.3 0.488 0.793 disease
LOX 4015 Congenital aneurysm of ascending aorta C0345050 Congenital Abnormality 0.3 0.488 0.793 disease
LOX 4015 Aortic Aneurysm, Thoracic C0162872 Disease or Syndrome 0.32 0.488 0.793 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types