ALTITUDEOMICSDB

Arylsulfatase E (chondrodysplasia punctata 1)

AltitudeomicsDB

Protein Official symbol	ARSE
Aliases	ARSL ARSE
Chromosomal Location	X
Length	589
Uniprot ID	P51690
EC number	3.1.6.-
Protein family Information(Pfam)	PF00884;
PDB id	None
InterPro ID	IPR017850;IPR024607;IPR000917;
dbSNP	rs122460151 rs122460153 rs122460152 rs80338711 rs34412194 rs122460154 rs35143646 rs80338713 rs122460155 rs28935474

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
ARSH	SUMF1	0.987
SUMF1	ARSA	0.98
ARSG	SUMF1	0.976
SUMF1	ARSB	0.976
ARSI	SUMF1	0.974
ARSJ	SUMF1	0.973
SUMF1	STS	0.973
ARSF	SUMF1	0.97
ARSE	SUMF1	0.968
ARSK	SUMF1	0.968
ARSD	SUMF1	0.968
ARSH	SUMF2	0.966
ARSK	ARSJ	0.96
SUMF2	ARSA	0.957
SUMF2	STS	0.953
SUMF2	ARSI	0.952
ARSD	SUMF2	0.951
SUMF2	ARSB	0.951
ARSK	ARSB	0.949
SUMF2	ARSJ	0.949
ARSK	ARSI	0.948
ARSF	SUMF2	0.947
ARSH	ARSK	0.947
ARSE	SUMF2	0.946
ARSG	SUMF2	0.946
ARSG	ARSK	0.944
ARSH	ARSB	0.941
ARSH	ARSI	0.941
SUMF2	SUMF1	0.937
ARSE	ARSJ	0.937
ARSD	ARSB	0.937
ARSK	SUMF2	0.936
ARSB	ARSA	0.936
ARSF	ARSB	0.934
ARSB	STS	0.934
ARSE	ARSB	0.933
ARSH	ARSJ	0.932
ARSG	ARSH	0.926
ARSI	STS	0.925
ARSK	ARSA	0.925
ARSH	ARSA	0.924
ARSG	ARSB	0.923
ARSD	ARSA	0.922
ARSE	ARSI	0.922
ARSG	ARSI	0.921
ARSG	ARSJ	0.921
ARSD	ARSJ	0.921
ARSG	ARSA	0.921
ARSD	ARSI	0.92
ARSJ	STS	0.92
ARSJ	ARSA	0.92
ARSI	ARSA	0.92
ARSF	ARSA	0.919
ARSE	ARSK	0.918
ARSF	ARSK	0.918
ARSD	ARSK	0.918
STS	ARSA	0.917
ARSK	STS	0.917
ARSE	ARSA	0.916
ARSF	ARSI	0.916
ARSF	ARSJ	0.916
ARSD	ARSF	0.915
ARSF	STS	0.912
ARSG	STS	0.911
ARSE	ARSG	0.91
ARSE	STS	0.91
ARSG	ARSF	0.909
ARSG	ARSD	0.909
ARSI	ARSJ	0.908
ARSH	STS	0.906
ARSD	STS	0.906
ARSE	ARSF	0.905
ARSE	ARSD	0.904
ARSH	ARSF	0.904
ARSE	ARSH	0.904
ARSI	ARSB	0.903
ARSJ	ARSB	0.903
ARSD	ARSH	0.903

Gene Ontology Semantic Similarity

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#	347527 (ARSH)	285362 (SUMF1)	22901 (ARSG)	340075 (ARSI)	79642 (ARSJ)	416 (ARSF)	415 (ARSE)	153642 (ARSK)	414 (ARSD)	411 (ARSB)	412 (STS)	410 (ARSA)
347527 (ARSH)	1.00	0.36	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.86	1.00
285362 (SUMF1)	0.36	1.00	0.36	0.26	0.36	0.36	0.36	0.36	0.36	0.23	0.25	0.37
22901 (ARSG)	1.00	0.36	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.86	1.00
340075 (ARSI)	1.00	0.26	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.72	0.66	0.85
79642 (ARSJ)	1.00	0.36	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.86	1.00
416 (ARSF)	1.00	0.36	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.86	1.00
415 (ARSE)	1.00	0.36	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.86	1.00
153642 (ARSK)	1.00	0.36	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.86	1.00
414 (ARSD)	1.00	0.36	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.86	1.00
411 (ARSB)	1.00	0.23	1.00	0.72	1.00	1.00	1.00	1.00	1.00	1.00	0.83	0.67
412 (STS)	0.86	0.25	0.86	0.66	0.86	0.86	0.86	0.86	0.86	0.83	1.00	0.69
410 (ARSA)	1.00	0.37	1.00	0.85	1.00	1.00	1.00	1.00	1.00	0.67	0.69	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
ARSE	Human	Blood	-	3650 m	48 hours	upregulated	1.423	Microarray	Himalayas	Indians	1	HAPE Pateints Vs Normal	http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
CTCF	10664	ARSE	415	distal	22955619	TRANSFAC
EP300	2033	ARSE	415	distal	22955619	TRANSFAC
SRF	6722	ARSE	415	distal	22955619	TRANSFAC
STAT1	6772	ARSE	415	distal	22955619	TRANSFAC

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT444146	hsa-miR-2276-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22100165
MIRT444147	hsa-miR-3682-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22100165
MIRT444145	hsa-miR-4696	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22100165
MIRT444144	hsa-miR-526b-5p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22100165
MIRT615207	hsa-miR-4659b-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615208	hsa-miR-4659a-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615211	hsa-miR-211-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615213	hsa-miR-204-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615220	hsa-miR-4722-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615216	hsa-miR-4287	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615219	hsa-miR-6727-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615209	hsa-miR-6875-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615217	hsa-miR-4469	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615218	hsa-miR-6747-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615215	hsa-miR-4685-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615222	hsa-miR-4667-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615223	hsa-miR-1470	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615210	hsa-miR-3074-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615221	hsa-miR-6832-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615212	hsa-miR-6817-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT615214	hsa-miR-4769-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT617347	hsa-miR-129-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT617347	hsa-miR-129-5p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT617347	hsa-miR-129-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	27418678
MIRT636863	hsa-miR-4763-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636861	hsa-miR-4713-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636869	hsa-miR-150-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636870	hsa-miR-8079	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636867	hsa-miR-2116-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636858	hsa-miR-4326	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636864	hsa-miR-6781-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636865	hsa-miR-2682-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636866	hsa-miR-3120-5p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636871	hsa-miR-1245a	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636859	hsa-miR-6894-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636862	hsa-miR-5001-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636860	hsa-miR-6888-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT636868	hsa-miR-532-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT642801	hsa-miR-3977	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT642800	hsa-miR-6885-3p	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT762188	hsa-miR-1285-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT763482	hsa-miR-196a-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT763529	hsa-miR-197-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT765291	hsa-miR-3187-5p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT767910	hsa-miR-3976	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	27418678
MIRT767910	hsa-miR-3976	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT769997	hsa-miR-4524a-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT770029	hsa-miR-4524b-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT773541	hsa-miR-5189-5p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT773123	hsa-miR-508-5p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT773304	hsa-miR-5096	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT775404	hsa-miR-599	Homo sapiens	ARSE	415	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	27418678
MIRT775404	hsa-miR-599	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT775832	hsa-miR-612	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT776877	hsa-miR-6512-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT777723	hsa-miR-6720-5p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT779876	hsa-miR-6823-5p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT780540	hsa-miR-6860	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT781830	hsa-miR-766-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT782782	hsa-miR-939-3p	Homo sapiens	ARSE	415	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025

Gene Ontology

ID	GO ID	GO Term	GO Type
415	GO:0008484	protein-tyrosine sulfotransferase activity	GOTERM_MF_DIRECT
415	GO:0005795	Golgi stack	GOTERM_CC_DIRECT
415	GO:0008152	metabolic process	GOTERM_BP_DIRECT
415	GO:0006687	glycosphingolipid metabolic process	GOTERM_BP_DIRECT
415	GO:0046872	metal ion binding	GOTERM_MF_DIRECT
415	GO:0001501	skeletal system development	GOTERM_BP_DIRECT
415	GO:0004065	arylesterase activity	GOTERM_MF_DIRECT
415	GO:0043687	post-translational protein modification	GOTERM_BP_DIRECT
415	GO:0016021	integral component of membrane	GOTERM_CC_DIRECT
415	GO:0005788	endoplasmic reticulum lumen	GOTERM_CC_DIRECT
415	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
ARSE	415	Brachytelephalangic Chondrodysplasia Punctata	C1844853	Disease or Syndrome	0.73	0.735	0.448	disease
ARSE	415	Peroxisomal Disorders	C0282528	Disease or Syndrome	0.3	0.735	0.448	group
ARSE	415	Intellectual Disability	C3714756	Mental or Behavioral Dysfunction	0.3	0.735	0.448	group
ARSE	415	Chondrodysplasia Punctata	C0008445	Congenital Abnormality	0.35	0.735	0.448	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types