Macrophage migration inhibitory factor

AltitudeomicsDB
Protein Official symbol MIF
Aliases MIF GLIF MMIF
Chromosomal Location  10
Length 115
Uniprot ID P14174
EC number 5.3.2.1; 5.3.3.12
Protein family Information(Pfam) PF01187;
PDB id 1CA7;1CGQ;1GCZ;1GD0;1GIF;1LJT;1MIF;1P1G;2OOH;2OOW;2OOZ;3B9S;3CE4;3DJH;3DJI;3HOF;3IJG;3IJJ;3JSF;3JSG;3JTU;3L5P;3L5R;3L5S;3L5T;3L5U;3L5V;3SMB;3SMC;3U18;3WNR;3WNS;3WNT;4ETG;4EUI;4EVG;4F2K;4GRN;4GRO;4GRP;4GRQ;4GRR;4GRU;4GUM;4K9G;4OSF;4OYQ;4P01;4P0H;4PKK;4PKZ;4PLU;4TRF;4TRU;4WR8;4WRB;4XX7;4XX8;4Z15;4Z1T;4Z1U;5B4O;5BS9;5BSC;5BSI;5BSJ;5EIZ;5HVS;5HVT;5HVV;5J7P;5J7Q;5UMJ;5UMK;5UZY;5V70;5V73;5XEJ;6B1C;6B1K;6B2C;6BG6;6BG7;6CB5;6CBF;6CBG;6CBH;6FVE;6FVH;6PEG;
InterPro ID IPR001398;IPR019829;IPR014347;
dbSNP None

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TAT HPD 0.994
MIF CD74 0.979
TAT GOT2 0.941
GOT1 GOT2 0.931
GOT1 TAT 0.93
GOT1 HPD 0.928
HPD GOT2 0.927
GOT2 MIF 0.925
GOT1 MIF 0.911
STAT4 MIF 0.91
IL4I1 HPD 0.91
IL4I1 MIF 0.901
TAT MIF 0.9
HPD MIF 0.9
Gene Ontology Semantic Similarity
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# 6898 (TAT) 4282 (MIF) 2805 (GOT1) 3242 (HPD) 2806 (GOT2) 6775 (STAT4) 259307 (IL4I1) 972 (CD74)
6898 (TAT) 1.00 0.59 0.52 0.16 0.53 0.57 0.27 0.62
4282 (MIF) 0.59 1.00 0.16 0.18 0.26 0.62 0.27 0.65
2805 (GOT1) 0.52 0.16 1.00 0.18 0.71 0.15 0.32 0.11
3242 (HPD) 0.16 0.18 0.18 1.00 0.18 0.14 0.55 0.14
2806 (GOT2) 0.53 0.26 0.71 0.18 1.00 0.24 0.29 0.24
6775 (STAT4) 0.57 0.62 0.15 0.14 0.24 1.00 0.23 0.64
259307 (IL4I1) 0.27 0.27 0.32 0.55 0.29 0.23 1.00 0.19
972 (CD74) 0.62 0.65 0.11 0.14 0.24 0.64 0.19 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MIF Mice Blood 8% Oxygen 7600 m 24 hours upregulated 1.4 RT-qPCR Western US C57BL/6 mice 2.6 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
MIF Mice Blood 8% Oxygen 7600 m 24 hours upregulated 5.2 RT-qPCR Western US C57BL/6 mice 2.6 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
MIF Human Vascular Smooth Muscles 3-10% Oxygen 5800 m 2 hours upregulated - - - - - Soldier exposed to high altitude compared to their low altitude profile http://dx.doi.org/10.4172/jpb.S3-004
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 MIF 4282 distal 22955619 TRANSFAC
CTCF 10664 MIF 4282 proximal_filtered 22955619 TRANSFAC
NFKB1 4790 MIF 4282 Activation 17018379 TRUSST
SP1 6667 MIF 4282 Unknown 10601358 TRUSST
RELA 5970 MIF 4282 Activation 17018379 TRUSST
HBP1 26959 MIF 4282 Repression 10601358 TRUSST
HIF1A 3091 MIF 4282 Activation 19717648 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT000046 hsa-miR-451a Homo sapiens MIF 4282 Homo sapiens ELISA//Luciferase reporter assay//Microarray//qRT-PCR//Western blot Functional MTI 19318487
MIRT000046 hsa-miR-451a Homo sapiens MIF 4282 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 24138931
MIRT000046 hsa-miR-451a Homo sapiens MIF 4282 Homo sapiens Luciferase reporter assay Functional MTI 26884830
MIRT000046 hsa-miR-451a Homo sapiens MIF 4282 Homo sapiens Luciferase reporter assay Functional MTI 28086136
MIRT037678 hsa-miR-744-5p Homo sapiens MIF 4282 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039145 hsa-miR-769-5p Homo sapiens MIF 4282 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044670 hsa-miR-320a Homo sapiens MIF 4282 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT733415 hsa-miR-146a-5p Homo sapiens MIF 4282 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27569893
MIRT734321 hsa-miR-1228-5p Homo sapiens MIF 4282 Homo sapiens ELISA//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 28465246
Gene Ontology
ID GO ID GO Term GO Type
4282 GO:0006954 inflammatory response GOTERM_BP_DIRECT
4282 GO:0010629 negative regulation of gene expression GOTERM_BP_DIRECT
4282 GO:0001516 prostaglandin biosynthetic process GOTERM_BP_DIRECT
4282 GO:0007569 cell aging GOTERM_BP_DIRECT
4282 GO:0007166 cell surface receptor signaling pathway GOTERM_BP_DIRECT
4282 GO:0002906 negative regulation of mature B cell apoptotic process GOTERM_BP_DIRECT
4282 GO:0008283 cell proliferation GOTERM_BP_DIRECT
4282 GO:0061078 positive regulation of prostaglandin secretion involved in immune response GOTERM_BP_DIRECT
4282 GO:0005515 protein binding GOTERM_MF_DIRECT
4282 GO:0050178 L-xylulose reductase GOTERM_MF_DIRECT
4282 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
4282 GO:0090344 negative regulation of cell aging GOTERM_BP_DIRECT
4282 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response GOTERM_BP_DIRECT
4282 GO:0005576 extracellular region GOTERM_CC_DIRECT
4282 GO:2000343 positive regulation of chemokine GOTERM_BP_DIRECT
4282 GO:0005125 cytokine activity GOTERM_MF_DIRECT
4282 GO:0005126 cytokine activity GOTERM_MF_DIRECT
4282 GO:0042056 neurexin family protein binding GOTERM_MF_DIRECT
4282 GO:0030330 DNA damage response GOTERM_BP_DIRECT
4282 GO:0043518 negative regulation of DNA damage response GOTERM_BP_DIRECT
4282 GO:0070207 protein homotrimerization GOTERM_BP_DIRECT
4282 GO:0005102 receptor binding GOTERM_MF_DIRECT
4282 GO:0050715 positive regulation of cytokine secretion GOTERM_BP_DIRECT
4282 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway GOTERM_BP_DIRECT
4282 GO:0048146 positive regulation of fibroblast proliferation GOTERM_BP_DIRECT
4282 GO:0042327 positive regulation of phosphorylation GOTERM_BP_DIRECT
4282 GO:0043406 positive regulation of MAP kinase activity GOTERM_BP_DIRECT
4282 GO:0004167 dihydroorotase activity GOTERM_MF_DIRECT
4282 GO:0010739 positive regulation of protein kinase A signaling GOTERM_BP_DIRECT
4282 GO:0032269 negative regulation of cellular protein metabolic process GOTERM_BP_DIRECT
4282 GO:0045087 innate immune response GOTERM_BP_DIRECT
4282 GO:0070374 positive regulation of ERK1 and ERK2 cascade GOTERM_BP_DIRECT
4282 GO:0009986 cell surface GOTERM_CC_DIRECT
4282 GO:0030890 positive regulation of B cell proliferation GOTERM_BP_DIRECT
4282 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
4282 GO:0019752 carboxylic acid metabolic process GOTERM_BP_DIRECT
4282 GO:0050900 leukocyte migration GOTERM_BP_DIRECT
4282 GO:0005615 extracellular space GOTERM_CC_DIRECT
4282 GO:0005737 cytoplasm GOTERM_CC_DIRECT
4282 GO:0043030 regulation of macrophage activation GOTERM_BP_DIRECT
4282 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GOTERM_BP_DIRECT
4282 GO:0031982 vesicle GOTERM_CC_DIRECT
4282 GO:0033033 negative regulation of myeloid cell apoptotic process GOTERM_BP_DIRECT
4282 GO:0033138 positive regulation of peptidyl-serine phosphorylation GOTERM_BP_DIRECT
4282 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GOTERM_BP_DIRECT
4282 GO:0050918 positive chemotaxis GOTERM_BP_DIRECT
4282 GO:0071157 negative regulation of cell cycle arrest GOTERM_BP_DIRECT
4282 GO:0090238 positive regulation of arachidonic acid secretion GOTERM_BP_DIRECT
4282 GO:0043209 myelin sheath GOTERM_CC_DIRECT
4282 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
4282 hsa00350 Tyrosine metabolism
4282 hsa00360 Phenylalanine metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MIF 4282 Colitis C0009319 Disease or Syndrome 0.51 0.457 0.862 disease
MIF 4282 Keloid C0022548 Acquired Abnormality 0.3 0.457 0.862 phenotype
MIF 4282 Pyemia C0034189 Pathologic Function 0.3 0.457 0.862 phenotype
MIF 4282 Anxiety Disorders C0003469 Mental or Behavioral Dysfunction 0.3 0.457 0.862 group
MIF 4282 Anaplastic carcinoma C0205696 Neoplastic Process 0.3 0.457 0.862 disease
MIF 4282 Breast Carcinoma C0678222 Neoplastic Process 0.35 0.457 0.862 disease
MIF 4282 Mammary Carcinoma, Animal C1257925 Neoplastic Process 0.3 0.457 0.862 disease
MIF 4282 Rheumatoid Arthritis C0003873 Disease or Syndrome 0.4 0.457 0.862 disease
MIF 4282 Undifferentiated carcinoma C0205698 Neoplastic Process 0.3 0.457 0.862 phenotype
MIF 4282 Memory Disorder, Semantic C0751293 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Memory Disorder, Spatial C0751294 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum C3658302 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Anxiety States, Neurotic C0376280 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Age-Related Memory Disorders C0751292 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Severe Sepsis C1719672 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Anxiety neurosis (finding) C1279420 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Rheumatoid Arthritis, Systemic Juvenile C1858558 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Mycoplasma-Induced Stevens-Johnson Syndrome C3658301 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Depressive Syndrome C0086133 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Malignant mesothelioma C0345967 Neoplastic Process 0.3 0.457 0.862 disease
MIF 4282 Endogenous depression C0011573 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Stevens-Johnson Syndrome C0038325 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Carcinoma, Spindle-Cell C0205697 Neoplastic Process 0.3 0.457 0.862 disease
MIF 4282 Memory impairment C0233794 Mental or Behavioral Dysfunction 0.3 0.457 0.862 phenotype
MIF 4282 Depression, Neurotic C0282126 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Autistic Disorder C0004352 Mental or Behavioral Dysfunction 0.31 0.457 0.862 group
MIF 4282 Mammary Neoplasms, Experimental C0024668 Experimental Model of Disease; Neoplastic Process 0.3 0.457 0.862 group
MIF 4282 Memory Loss C0751295 Sign or Symptom 0.3 0.457 0.862 phenotype
MIF 4282 Memory Disorders C0025261 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Prostatic Neoplasms C0033578 Neoplastic Process 0.34 0.457 0.862 group
MIF 4282 Sepsis C0243026 Disease or Syndrome 0.33 0.457 0.862 disease
MIF 4282 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.457 0.862 group
MIF 4282 Drug-Induced Stevens Johnson Syndrome C1274933 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Malignant neoplasm of breast C0006142 Neoplastic Process 0.34 0.457 0.862 disease
MIF 4282 Inflammation C0021368 Pathologic Function 0.36 0.457 0.862 phenotype
MIF 4282 Mammary Neoplasms C1458155 Neoplastic Process 0.32 0.457 0.862 group
MIF 4282 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Toxic Epidermal Necrolysis C0014518 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Animal Mammary Neoplasms C0024667 Neoplastic Process 0.3 0.457 0.862 group
MIF 4282 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.33 0.457 0.862 disease
MIF 4282 Septicemia C0036690 Disease or Syndrome 0.31 0.457 0.862 disease
MIF 4282 Carcinomatosis C0205699 Neoplastic Process 0.3 0.457 0.862 phenotype
MIF 4282 Carcinoma C0007097 Neoplastic Process 0.3 0.457 0.862 group
MIF 4282 Melancholia C0025193 Mental or Behavioral Dysfunction 0.3 0.457 0.862 disease
MIF 4282 Familial Ménière disease C4302111 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Juvenile-Onset Still Disease C0087031 Disease or Syndrome 0.3 0.457 0.862 disease
MIF 4282 Systemic onset juvenile chronic arthritis C1384600 Disease or Syndrome 0.32 0.457 0.862 disease
MIF 4282 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.01 0.457 0.862 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
MIF 4282 ANTI-MIF MONOCLONAL ANTIBODY None None None
MIF 4282 PPD None None None
MIF 4282 PMA PHORBOL MYRISTATE ACETATE CHEMBL279115 None