Unconventional myosin-Ie

AltitudeomicsDB
Protein Official symbol MYO1E
Aliases MYO1E MYO1C
Chromosomal Location  15
Length 1108
Uniprot ID Q12965
EC number None
Protein family Information(Pfam) PF00063;PF06017;PF00018;
PDB id None
InterPro ID IPR035507;IPR000048;IPR036961;IPR001609;IPR010926;IPR036072;IPR027417;IPR036028;IPR001452;
dbSNP rs387906807 rs141565214 rs1173043275 rs180951130 rs147579391

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PITPNA SCARF1 0.804
PITPNA MYO1E 0.749
MYO1E SCARF1 0.749
CDH23 MYO1E 0.734
SLC2A4 MYO1E 0.707
Gene Ontology Semantic Similarity
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# 8578 (SCARF1) 4643 (MYO1E) 5306 (PITPNA) 64072 (CDH23) 6517 (SLC2A4)
8578 (SCARF1) 1.00 0.21 0.15 0.36 0.20
4643 (MYO1E) 0.21 1.00 0.39 1.00 0.43
5306 (PITPNA) 0.15 0.39 1.00 0.34 0.27
64072 (CDH23) 0.36 1.00 0.34 1.00 1.00
6517 (SLC2A4) 0.20 0.43 0.27 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MYO1E Bird Lungs - 4000 m Native upregulated 1.52 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
SRF 6722 MYO1E 4643 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT001531 hsa-miR-155-5p Homo sapiens MYO1E 4643 Homo sapiens pSILAC//Proteomics;Other Functional MTI (Weak) 18668040
MIRT023408 hsa-miR-30b-5p Homo sapiens MYO1E 4643 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT028066 hsa-miR-93-5p Homo sapiens MYO1E 4643 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT032300 hsa-let-7b-5p Homo sapiens MYO1E 4643 Homo sapiens Proteomics Functional MTI (Weak) 18668040
Gene Ontology
ID GO ID GO Term GO Type
4643 GO:0000146 fatty-acyl-CoA binding GOTERM_MF_DIRECT
4643 GO:0015629 actin cytoskeleton GOTERM_CC_DIRECT
4643 GO:0030048 actin filament-based movement GOTERM_BP_DIRECT
4643 GO:0005515 protein binding GOTERM_MF_DIRECT
4643 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
4643 GO:0005516 calmodulin binding GOTERM_MF_DIRECT
4643 GO:0005911 cell-cell junction GOTERM_CC_DIRECT
4643 GO:0016459 myosin complex GOTERM_CC_DIRECT
4643 GO:0005524 ATP binding GOTERM_MF_DIRECT
4643 GO:0035091 histone acetyltransferase binding GOTERM_MF_DIRECT
4643 GO:0005912 adherens junction GOTERM_CC_DIRECT
4643 GO:0001701 in utero embryonic development GOTERM_BP_DIRECT
4643 GO:0003094 glomerular filtration GOTERM_BP_DIRECT
4643 GO:0005856 cytoskeleton GOTERM_CC_DIRECT
4643 GO:0051015 actin filament binding GOTERM_MF_DIRECT
4643 GO:0005737 cytoplasm GOTERM_CC_DIRECT
4643 GO:0006807 nitrogen compound metabolic process GOTERM_BP_DIRECT
4643 GO:0035166 post-embryonic hemopoiesis GOTERM_BP_DIRECT
4643 GO:0003774 protein disulfide isomerase activity GOTERM_MF_DIRECT
4643 GO:0048008 platelet-derived growth factor receptor signaling pathway GOTERM_BP_DIRECT
4643 GO:0072015 glomerular visceral epithelial cell development GOTERM_BP_DIRECT
4643 GO:0042623 lipid phosphatase activity GOTERM_MF_DIRECT
4643 GO:0045334 clathrin-coated endocytic vesicle GOTERM_CC_DIRECT
4643 GO:0030136 clathrin-coated vesicle GOTERM_CC_DIRECT
4643 GO:0032836 glomerular basement membrane development GOTERM_BP_DIRECT
4643 GO:0005903 brush border GOTERM_CC_DIRECT
4643 GO:0001570 vasculogenesis GOTERM_BP_DIRECT
4643 GO:0006897 endocytosis GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MYO1E 4643 Hyalinosis, Segmental Glomerular C0086432 Disease or Syndrome 0.3 0.743 0.172 disease
MYO1E 4643 Focal glomerulosclerosis C0017668 Disease or Syndrome 0.43 0.743 0.172 disease
MYO1E 4643 FOCAL SEGMENTAL GLOMERULOSCLEROSIS 6 C3279905 Disease or Syndrome 0.4 0.743 0.172 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types