Na/K-transporting ATPase sub. α-1

AltitudeomicsDB
Protein Official symbol ATP1A1
Aliases ATP1A1
Chromosomal Location 1
Length 1023
Uniprot ID P05023
EC number 7.2.2.13
Protein family Information(Pfam) PF00689;PF00690;
PDB id None
InterPro ID IPR006068;IPR004014;IPR023299;IPR018303;IPR023298;IPR008250;IPR036412;IPR023214;IPR005775;IPR001757;
dbSNP rs12564026 rs1553190285 rs1553192086 rs1553192091 rs1553192783

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ATP1A1 ATP1B1 0.997
ATP1A1 FXYD2 0.995
ATP1B1 FXYD2 0.9890000000000001
ATP1A1 ATP1B2 0.985
ATP1B1 FXYD7 0.983
ATP1A1 ATP1B3 0.983
FXYD2 ATP1B3 0.975
FXYD2 ATP1B2 0.9670000000000001
FXYD2 ATP1B4 0.9540000000000001
ATP1A1 FXYD7 0.9420000000000001
FXYD1 ATP1A1 0.9420000000000001
FXYD1 ATP1B1 0.9309999999999999
FXYD6 ATP1B2 0.9309999999999999
FXYD3 ATP1B1 0.924
FXYD3 ATP1B2 0.9229999999999999
FXYD7 ATP1B2 0.922
FXYD6 ATP1B3 0.9209999999999999
FXYD3 ATP1B3 0.92
FXYD6 ATP1A1 0.917
FXYD3 ATP1A1 0.915
FXYD4 ATP1B1 0.915
ATP1B1 ATP1B2 0.914
FXYD1 ATP1B2 0.9129999999999999
ATP1A1 ATP1B4 0.912
FXYD6 ATP1B1 0.912
FXYD4 ATP1B2 0.912
ATP1B1 ATP1B3 0.9109999999999999
FXYD4 ATP1B3 0.91
FXYD1 ATP1B3 0.909
FXYD4 ATP1A1 0.9059999999999999
ATP1B3 ATP1B2 0.9059999999999999
ATP1B3 FXYD7 0.9059999999999999
Gene Ontology Semantic Similarity
Download Tab separated file
# 476 (ATP1A1) 481 (ATP1B1) 486 (FXYD2) 5348 (FXYD1) 53826 (FXYD6) 5349 (FXYD3) 53822 (FXYD7) 53828 (FXYD4) 483 (ATP1B3) 482 (ATP1B2) 23439 (ATP1B4)
476 (ATP1A1) 1.00 0.79 0.38 0.39 0.47 0.21 0.47 0.21 0.49 0.62 0.46
481 (ATP1B1) 0.79 1.00 0.37 0.37 0.46 0.27 0.44 0.27 0.64 0.73 0.46
486 (FXYD2) 0.38 0.37 1.00 0.52 0.62 1.00 0.55 1.00 0.50 0.49 0.46
5348 (FXYD1) 0.39 0.37 0.52 1.00 0.80 1.00 0.91 1.00 0.34 0.46 0.10
53826 (FXYD6) 0.47 0.46 0.62 0.80 1.00 1.00 0.90 1.00 0.39 0.54 0.22
5349 (FXYD3) 0.21 0.27 1.00 1.00 1.00 1.00 1.00 1.00 0.27 0.27 0.10
53822 (FXYD7) 0.47 0.44 0.55 0.91 0.90 1.00 1.00 1.00 0.39 0.55 0.12
53828 (FXYD4) 0.21 0.27 1.00 1.00 1.00 1.00 1.00 1.00 0.27 0.27 0.10
483 (ATP1B3) 0.49 0.64 0.50 0.34 0.39 0.27 0.39 0.27 1.00 0.96 0.46
482 (ATP1B2) 0.62 0.73 0.49 0.46 0.54 0.27 0.55 0.27 0.96 1.00 0.46
23439 (ATP1B4) 0.46 0.46 0.46 0.10 0.22 0.10 0.12 0.10 0.46 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ATP1A1 Rat Left brain cortices 300hPa 9144 m 1 hour downregulated 0.63±0.2 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT016292 hsa-miR-193b-3p Homo sapiens ATP1A1 476 Homo sapiens Proteomics Functional MTI (Weak) 21512034
MIRT019537 hsa-miR-340-5p Homo sapiens ATP1A1 476 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT028862 hsa-miR-26b-5p Homo sapiens ATP1A1 476 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT038912 hsa-miR-93-3p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT041714 hsa-miR-484 Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044531 hsa-miR-320a Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046260 hsa-miR-23b-3p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT047825 hsa-miR-30d-5p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048222 hsa-miR-196a-5p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048123 hsa-miR-197-3p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048687 hsa-miR-99a-5p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT049192 hsa-miR-92a-3p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050108 hsa-miR-26a-5p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050658 hsa-miR-18a-5p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052345 hsa-let-7b-5p Homo sapiens ATP1A1 476 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT719041 hsa-miR-3124-3p Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT719042 hsa-miR-1250-5p Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT719043 hsa-miR-6753-5p Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT719040 hsa-miR-4746-3p Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT719044 hsa-miR-1911-3p Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT719038 hsa-miR-155-3p Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT719037 hsa-miR-3685 Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT719039 hsa-miR-3160-5p Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT719036 hsa-miR-384 Homo sapiens ATP1A1 476 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
Gene Ontology
ID GO ID GO Term GO Type
476 GO:0045989 positive regulation of striated muscle contraction GOTERM_BP_DIRECT
476 GO:0086002 cardiac muscle cell action potential involved in contraction GOTERM_BP_DIRECT
476 GO:0086064 cell communication by electrical coupling involved in cardiac conduction GOTERM_BP_DIRECT
476 GO:1903779 regulation of cardiac conduction GOTERM_BP_DIRECT
476 GO:0019901 kinase binding GOTERM_MF_DIRECT
476 GO:0042383 sarcolemma GOTERM_CC_DIRECT
476 GO:0008217 regulation of blood pressure GOTERM_BP_DIRECT
476 GO:0005391 water transmembrane transporter activity GOTERM_MF_DIRECT
476 GO:0030506 thyroid hormone receptor coactivator activity GOTERM_MF_DIRECT
476 GO:0043531 MRF binding GOTERM_MF_DIRECT
476 GO:0016020 membrane GOTERM_CC_DIRECT
476 GO:0031402 phosphatidylcholine binding GOTERM_MF_DIRECT
476 GO:0086009 membrane repolarization GOTERM_BP_DIRECT
476 GO:1903416 response to glycoside GOTERM_BP_DIRECT
476 GO:0010107 potassium ion import GOTERM_BP_DIRECT
476 GO:0016324 apical plasma membrane GOTERM_CC_DIRECT
476 GO:0002028 regulation of sodium ion transport GOTERM_BP_DIRECT
476 GO:0055119 relaxation of cardiac muscle GOTERM_BP_DIRECT
476 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
476 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
476 GO:0002026 regulation of the force of heart contraction GOTERM_BP_DIRECT
476 GO:0030007 cellular potassium ion homeostasis GOTERM_BP_DIRECT
476 GO:0000166 microfilament motor activity GOTERM_MF_DIRECT
476 GO:0005515 protein binding GOTERM_MF_DIRECT
476 GO:0051087 unfolded protein binding GOTERM_MF_DIRECT
476 GO:0005886 plasma membrane GOTERM_CC_DIRECT
476 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
476 GO:0016323 basolateral plasma membrane GOTERM_CC_DIRECT
476 GO:0006883 cellular sodium ion homeostasis GOTERM_BP_DIRECT
476 GO:0045822 negative regulation of heart contraction GOTERM_BP_DIRECT
476 GO:0071260 cellular response to mechanical stimulus GOTERM_BP_DIRECT
476 GO:0086013 membrane repolarization during cardiac muscle cell action potential GOTERM_BP_DIRECT
476 GO:0016791 hydrolase activity GOTERM_MF_DIRECT
476 GO:0031947 negative regulation of glucocorticoid biosynthetic process GOTERM_BP_DIRECT
476 GO:0071383 cellular response to steroid hormone stimulus GOTERM_BP_DIRECT
476 GO:0086004 regulation of cardiac muscle cell contraction GOTERM_BP_DIRECT
476 GO:0042493 response to drug GOTERM_BP_DIRECT
476 GO:0030955 calcium-dependent ATPase activity GOTERM_MF_DIRECT
476 GO:0005768 endosome GOTERM_CC_DIRECT
476 GO:0030315 T-tubule GOTERM_CC_DIRECT
476 GO:0043209 myelin sheath GOTERM_CC_DIRECT
476 GO:0043234 protein complex GOTERM_CC_DIRECT
476 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
476 GO:0015991 ATP hydrolysis coupled proton transport GOTERM_BP_DIRECT
476 GO:0016311 dephosphorylation GOTERM_BP_DIRECT
476 GO:0034220 ion transmembrane transport GOTERM_BP_DIRECT
476 GO:0036376 sodium ion export from cell GOTERM_BP_DIRECT
476 GO:0045823 positive regulation of heart contraction GOTERM_BP_DIRECT
476 GO:0060081 membrane hyperpolarization GOTERM_BP_DIRECT
476 GO:1990573 potassium ion import across plasma membrane GOTERM_BP_DIRECT
476 GO:0019904 protein phosphatase binding GOTERM_MF_DIRECT
476 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient GOTERM_BP_DIRECT
476 GO:0005901 caveola GOTERM_CC_DIRECT
476 GO:0043231 intracellular membrane-bounded organelle GOTERM_CC_DIRECT
476 GO:0060048 cardiac muscle contraction GOTERM_BP_DIRECT
476 GO:0005524 ATP binding GOTERM_MF_DIRECT
476 GO:0043548 protein serine/threonine kinase activator activity GOTERM_MF_DIRECT
476 GO:0046872 metal ion binding GOTERM_MF_DIRECT
476 GO:1990239 cuprous ion binding GOTERM_MF_DIRECT
476 GO:0005890 sodium:potassium-exchanging ATPase complex GOTERM_CC_DIRECT
476 GO:0014069 postsynaptic density GOTERM_CC_DIRECT
476 GO:0014704 intercalated disc GOTERM_CC_DIRECT
476 GO:0042470 melanosome GOTERM_CC_DIRECT
476 GO:1903561 extracellular vesicle GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
476 hsa04024 cAMP signaling pathway
476 hsa04022 cGMP-PKG signaling pathway
476 hsa04260 Cardiac muscle contraction
476 hsa04261 Adrenergic signaling in cardiomyocytes
476 hsa04960 Aldosterone-regulated sodium reabsorption
476 hsa04970 Salivary secretion
476 hsa04972 Pancreatic secretion
476 hsa04964 Proximal tubule bicarbonate reclamation
476 hsa04918 Thyroid hormone synthesis
476 hsa04973 Carbohydrate digestion and absorption
476 hsa04961 Endocrine and other factor-regulated calcium reabsorption
476 hsa04919 Thyroid hormone signaling pathway
476 hsa04974 Protein digestion and absorption
476 hsa04976 Bile secretion
476 hsa04911 Insulin secretion
476 hsa04971 Gastric acid secretion
476 hsa04978 Mineral absorption
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ATP1A1 476 Adrenal Cortical Adenoma C0206667 Neoplastic Process 0.3 0.667 0.552 disease
ATP1A1 476 Hypertensive disease C0020538 Disease or Syndrome 0.56 0.667 0.552 group
ATP1A1 476 Vestibular Diseases C0042594 Disease or Syndrome 0.3 0.667 0.552 group
ATP1A1 476 Papillary adenoma C0205650 Neoplastic Process 0.3 0.667 0.552 disease
ATP1A1 476 Conn Syndrome C1384514 Disease or Syndrome 0.31 0.667 0.552 disease
ATP1A1 476 Adenoma, Microcystic C0205648 Neoplastic Process 0.3 0.667 0.552 disease
ATP1A1 476 Adenoma C0001430 Neoplastic Process 0.33 0.667 0.552 group
ATP1A1 476 Hyperaldosteronism C0020428 Disease or Syndrome 0.3 0.667 0.552 disease
ATP1A1 476 Myocardial Ischemia C0151744 Disease or Syndrome 0.3 0.667 0.552 disease
ATP1A1 476 Adenoma, Basal Cell C0205646 Neoplastic Process 0.3 0.667 0.552 disease
ATP1A1 476 Gastroenteritis, Transmissible, of Swine C0017162 Disease or Syndrome 0.3 0.667 0.552 disease
ATP1A1 476 Follicular adenoma C0205647 Neoplastic Process 0.3 0.667 0.552 disease
ATP1A1 476 Adenoma, Trabecular C0205651 Neoplastic Process 0.3 0.667 0.552 disease
ATP1A1 476 Adenoma, Monomorphic C0205649 Neoplastic Process 0.3 0.667 0.552 disease
ATP1A1 476 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.3 0.667 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ATP1A1 476 ACETYLDIGITOXIN ACETYLDIGITOXIN CHEMBL3545057 None
ATP1A1 476 ACETYLDIGITOXIN ACETYLDIGITOXIN CHEMBL3545057 inhibitor
ATP1A1 476 ACETYLDIGITOXIN ACETYLDIGITOXIN CHEMBL3545057 None
ATP1A1 476 ACETYLDIGITOXIN ACETYLDIGITOXIN CHEMBL3545057 inhibitor
ATP1A1 476 ALMITRINE ALMITRINE CHEMBL1183717 None
ATP1A1 476 ALMITRINE ALMITRINE CHEMBL1183717 binder
ATP1A1 476 ALMITRINE ALMITRINE CHEMBL1183717 None
ATP1A1 476 ALUMINIUM CHEMBL444449 CHEMBL444449 binder
ATP1A1 476 ARTEMETHER None None binder
ATP1A1 476 BEPRIDIL BEPRIDIL CHEMBL1008 None
ATP1A1 476 BEPRIDIL BEPRIDIL CHEMBL1008 None
ATP1A1 476 CHLOROPROCAINE None None blocker
ATP1A1 476 CICLOPIROX CICLOPIROX CHEMBL1413 binder
ATP1A1 476 DESLANOSIDE DESLANOSIDE CHEMBL1614 None
ATP1A1 476 DESLANOSIDE DESLANOSIDE CHEMBL1614 inhibitor
ATP1A1 476 DESLANOSIDE DESLANOSIDE CHEMBL1614 inhibitor
ATP1A1 476 DESLANOSIDE DESLANOSIDE CHEMBL1614 binder
ATP1A1 476 DESLANOSIDE DESLANOSIDE CHEMBL1614 None
ATP1A1 476 DIGOXIN DIGOXIN CHEMBL1751 inhibitor
ATP1A1 476 DIGITOXIN DIGITOXIN CHEMBL254219 inhibitor
ATP1A1 476 DIGITOXIN DIGITOXIN CHEMBL254219 None
ATP1A1 476 DIGOXIN DIGOXIN CHEMBL1751 None
ATP1A1 476 DIGITOXIN DIGITOXIN CHEMBL254219 None
ATP1A1 476 DIGITOXIN DIGITOXIN CHEMBL254219 inhibitor
ATP1A1 476 DIGOXIN DIGOXIN CHEMBL1751 inhibitor
ATP1A1 476 DIGOXIN DIGOXIN CHEMBL1751 None
ATP1A1 476 ISTAROXIME ISTAROXIME CHEMBL3138451 None
ATP1A1 476 LUMEFANTRINE CHEMBL38827 CHEMBL38827 binder
ATP1A1 476 OUABAIN OUABAIN CHEMBL222863 None
ATP1A1 476 OUABAIN OUABAIN CHEMBL222863 binder
ATP1A1 476 OUABAIN OUABAIN CHEMBL222863 None