Na/K-transporting ATPase sub. α-2

AltitudeomicsDB
Protein Official symbol ATP1A2
Aliases ATP1A2 KIAA0778
Chromosomal Location 1
Length 1020
Uniprot ID P50993
EC number 7.2.2.13
Protein family Information(Pfam) PF00689;PF00690;
PDB id None
InterPro ID IPR006068;IPR004014;IPR023299;IPR018303;IPR023298;IPR008250;IPR036412;IPR023214;IPR005775;IPR001757;
dbSNP rs1057518514 rs28934002 rs886039530 rs28933401 rs1553245771 rs28933400 rs28933398 rs28933399 rs746795369

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ATP1B1 ATP1A2 0.991
ATP1B1 FXYD2 0.9890000000000001
ATP1B1 FXYD7 0.983
ATP1A2 ATP1B2 0.982
FXYD2 ATP1B3 0.975
ATP1A2 FXYD2 0.968
FXYD2 ATP1B2 0.9670000000000001
ATP1A2 ATP1B3 0.9640000000000001
FXYD2 ATP1B4 0.9540000000000001
FXYD6 ATP1A2 0.943
FXYD1 ATP1A2 0.9359999999999999
FXYD1 ATP1B1 0.9309999999999999
FXYD6 ATP1B2 0.9309999999999999
ATP1A2 FXYD7 0.927
FXYD3 ATP1B1 0.924
FXYD3 ATP1B2 0.9229999999999999
FXYD7 ATP1B2 0.922
FXYD6 ATP1B3 0.9209999999999999
FXYD3 ATP1B3 0.92
ATP1A2 ATP1B4 0.915
FXYD4 ATP1B1 0.915
ATP1B1 ATP1B2 0.914
FXYD3 ATP1A2 0.914
FXYD1 ATP1B2 0.9129999999999999
FXYD4 ATP1A2 0.9129999999999999
FXYD4 ATP1B2 0.912
FXYD6 ATP1B1 0.912
ATP1B1 ATP1B3 0.9109999999999999
FXYD4 ATP1B3 0.91
FXYD1 ATP1B3 0.909
ATP1B3 FXYD7 0.9059999999999999
ATP1B3 ATP1B2 0.9059999999999999
Gene Ontology Semantic Similarity
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# 481 (ATP1B1) 477 (ATP1A2) 486 (FXYD2) 53826 (FXYD6) 5348 (FXYD1) 5349 (FXYD3) 53822 (FXYD7) 53828 (FXYD4) 483 (ATP1B3) 482 (ATP1B2) 23439 (ATP1B4)
481 (ATP1B1) 1.00 0.87 0.37 0.46 0.37 0.27 0.44 0.27 0.64 0.73 0.46
477 (ATP1A2) 0.87 1.00 0.37 0.46 0.37 0.21 0.45 0.21 0.47 0.59 0.46
486 (FXYD2) 0.37 0.37 1.00 0.62 0.52 1.00 0.55 1.00 0.50 0.49 0.46
53826 (FXYD6) 0.46 0.46 0.62 1.00 0.80 1.00 0.90 1.00 0.39 0.54 0.22
5348 (FXYD1) 0.37 0.37 0.52 0.80 1.00 1.00 0.91 1.00 0.34 0.46 0.10
5349 (FXYD3) 0.27 0.21 1.00 1.00 1.00 1.00 1.00 1.00 0.27 0.27 0.10
53822 (FXYD7) 0.44 0.45 0.55 0.90 0.91 1.00 1.00 1.00 0.39 0.55 0.12
53828 (FXYD4) 0.27 0.21 1.00 1.00 1.00 1.00 1.00 1.00 0.27 0.27 0.10
483 (ATP1B3) 0.64 0.47 0.50 0.39 0.34 0.27 0.39 0.27 1.00 0.96 0.46
482 (ATP1B2) 0.73 0.59 0.49 0.54 0.46 0.27 0.55 0.27 0.96 1.00 0.46
23439 (ATP1B4) 0.46 0.46 0.46 0.22 0.10 0.10 0.12 0.10 0.46 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ATP1A2 Rat Left brain cortices 300hPa 9144 m 1 hour downregulated 0.62±0.1 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT003095 hsa-miR-122-5p Homo sapiens ATP1A2 477 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 19296470
MIRT047687 hsa-miR-10a-5p Homo sapiens ATP1A2 477 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048595 hsa-miR-100-5p Homo sapiens ATP1A2 477 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT660445 hsa-miR-6826-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660448 hsa-miR-6795-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660444 hsa-miR-6875-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660449 hsa-miR-4714-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660447 hsa-miR-4778-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660446 hsa-miR-3160-5p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663253 hsa-miR-4435 Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663254 hsa-miR-588 Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663259 hsa-miR-6832-5p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663264 hsa-miR-6823-5p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663268 hsa-miR-4781-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663251 hsa-miR-5096 Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663256 hsa-miR-548s Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663262 hsa-miR-1281 Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663258 hsa-miR-411-5p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663252 hsa-miR-3187-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663255 hsa-miR-4701-5p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663263 hsa-miR-4716-5p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663269 hsa-miR-4524b-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663265 hsa-miR-484 Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663266 hsa-miR-3155b Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663257 hsa-miR-197-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663260 hsa-miR-4755-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663267 hsa-miR-3155a Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT663261 hsa-miR-4524a-3p Homo sapiens ATP1A2 477 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
Gene Ontology
ID GO ID GO Term GO Type
477 GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse GOTERM_BP_DIRECT
477 GO:0055119 relaxation of cardiac muscle GOTERM_BP_DIRECT
477 GO:0006940 regulation of smooth muscle contraction GOTERM_BP_DIRECT
477 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient GOTERM_BP_DIRECT
477 GO:0086012 membrane depolarization during cardiac muscle cell action potential GOTERM_BP_DIRECT
477 GO:0051966 regulation of synaptic transmission GOTERM_BP_DIRECT
477 GO:0040011 locomotion GOTERM_BP_DIRECT
477 GO:0046034 ATP metabolic process GOTERM_BP_DIRECT
477 GO:0006813 potassium ion transport GOTERM_BP_DIRECT
477 GO:0008542 visual learning GOTERM_BP_DIRECT
477 GO:0051481 negative regulation of cytosolic calcium ion concentration GOTERM_BP_DIRECT
477 GO:0006942 regulation of striated muscle contraction GOTERM_BP_DIRECT
477 GO:0019229 regulation of vasoconstriction GOTERM_BP_DIRECT
477 GO:0008217 regulation of blood pressure GOTERM_BP_DIRECT
477 GO:0010107 potassium ion import GOTERM_BP_DIRECT
477 GO:0036376 sodium ion export from cell GOTERM_BP_DIRECT
477 GO:0071260 cellular response to mechanical stimulus GOTERM_BP_DIRECT
477 GO:0006883 cellular sodium ion homeostasis GOTERM_BP_DIRECT
477 GO:0015991 ATP hydrolysis coupled proton transport GOTERM_BP_DIRECT
477 GO:0002026 regulation of the force of heart contraction GOTERM_BP_DIRECT
477 GO:0008344 adult locomotory behavior GOTERM_BP_DIRECT
477 GO:0071383 cellular response to steroid hormone stimulus GOTERM_BP_DIRECT
477 GO:0006814 sodium ion transport GOTERM_BP_DIRECT
477 GO:0030007 cellular potassium ion homeostasis GOTERM_BP_DIRECT
477 GO:0045822 negative regulation of heart contraction GOTERM_BP_DIRECT
477 GO:0060048 cardiac muscle contraction GOTERM_BP_DIRECT
477 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GOTERM_BP_DIRECT
477 GO:0045988 negative regulation of striated muscle contraction GOTERM_BP_DIRECT
477 GO:0086004 regulation of cardiac muscle cell contraction GOTERM_BP_DIRECT
477 GO:0001504 neurotransmitter uptake GOTERM_BP_DIRECT
477 GO:0002087 regulation of respiratory gaseous exchange by neurological system process GOTERM_BP_DIRECT
477 GO:0034220 ion transmembrane transport GOTERM_BP_DIRECT
477 GO:0035094 response to nicotine GOTERM_BP_DIRECT
477 GO:0086009 membrane repolarization GOTERM_BP_DIRECT
477 GO:0086064 cell communication by electrical coupling involved in cardiac conduction GOTERM_BP_DIRECT
477 GO:0005768 endosome GOTERM_CC_DIRECT
477 GO:0005886 plasma membrane GOTERM_CC_DIRECT
477 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
477 GO:0005901 caveola GOTERM_CC_DIRECT
477 GO:0014704 intercalated disc GOTERM_CC_DIRECT
477 GO:0005890 sodium:potassium-exchanging ATPase complex GOTERM_CC_DIRECT
477 GO:0016887 ATPase activity GOTERM_MF_DIRECT
477 GO:1990239 coreceptor activity involved in Wnt signaling pathway GOTERM_MF_DIRECT
477 GO:0005737 cytoplasm GOTERM_CC_DIRECT
477 GO:1903561 extracellular vesicle GOTERM_CC_DIRECT
477 GO:1903170 negative regulation of calcium ion transmembrane transport GOTERM_BP_DIRECT
477 GO:0016020 membrane GOTERM_CC_DIRECT
477 GO:1903416 response to glycoside GOTERM_BP_DIRECT
477 GO:1903779 regulation of cardiac conduction GOTERM_BP_DIRECT
477 GO:0005524 ATP binding GOTERM_MF_DIRECT
477 GO:0005515 protein binding GOTERM_MF_DIRECT
477 GO:0046872 metal ion binding GOTERM_MF_DIRECT
477 GO:1990573 potassium ion import across plasma membrane GOTERM_BP_DIRECT
477 GO:0008144 poly GOTERM_MF_DIRECT
477 GO:0043197 dendritic spine GOTERM_CC_DIRECT
477 GO:1903280 negative regulation of calcium:sodium antiporter activity GOTERM_BP_DIRECT
477 GO:0030955 TPR domain binding GOTERM_MF_DIRECT
477 GO:0030315 T-tubule GOTERM_CC_DIRECT
477 GO:0005391 calcium-transporting ATPase activity GOTERM_MF_DIRECT
477 GO:0051087 unfolded protein binding GOTERM_MF_DIRECT
477 GO:0031402 small GTPase binding GOTERM_MF_DIRECT
477 GO:0043209 myelin sheath GOTERM_CC_DIRECT
477 GO:0043231 intracellular membrane-bounded organelle GOTERM_CC_DIRECT
477 GO:0000166 SNARE binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
477 hsa04024 cAMP signaling pathway
477 hsa04022 cGMP-PKG signaling pathway
477 hsa04261 Adrenergic signaling in cardiomyocytes
477 hsa04260 Cardiac muscle contraction
477 hsa04972 Pancreatic secretion
477 hsa04961 Endocrine and other factor-regulated calcium reabsorption
477 hsa04911 Insulin secretion
477 hsa04919 Thyroid hormone signaling pathway
477 hsa04960 Aldosterone-regulated sodium reabsorption
477 hsa04964 Proximal tubule bicarbonate reclamation
477 hsa04976 Bile secretion
477 hsa04973 Carbohydrate digestion and absorption
477 hsa04970 Salivary secretion
477 hsa04974 Protein digestion and absorption
477 hsa04978 Mineral absorption
477 hsa04918 Thyroid hormone synthesis
477 hsa04971 Gastric acid secretion
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ATP1A2 477 Hypertensive disease C0020538 Disease or Syndrome 0.5 0.624 0.31 group
ATP1A2 477 Alternating hemiplegia of childhood C0338488 Disease or Syndrome 0.52 0.624 0.31 disease
ATP1A2 477 MIGRAINE, FAMILIAL HEMIPLEGIC, 2 C1865322 Disease or Syndrome 0.69 0.624 0.31 disease
ATP1A2 477 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.43 0.624 0.31 group
ATP1A2 477 Epileptic encephalopathy C0543888 Disease or Syndrome 0.3 0.624 0.31 disease
ATP1A2 477 Hemiplegic migraine C0270862 Disease or Syndrome 0.4 0.624 0.31 disease
ATP1A2 477 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.31 0.624 0.31 disease
ATP1A2 477 Migraine, Familial Basilar C1865323 Disease or Syndrome 0.41 0.624 0.31 disease
ATP1A2 477 ALTERNATING HEMIPLEGIA OF CHILDHOOD 1 C3549447 Disease or Syndrome 0.4 0.624 0.31 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ATP1A2 477 ACETYLDIGITOXIN ACETYLDIGITOXIN CHEMBL3545057 inhibitor
ATP1A2 477 DESLANOSIDE DESLANOSIDE CHEMBL1614 inhibitor
ATP1A2 477 DIGITOXIN DIGITOXIN CHEMBL254219 inhibitor
ATP1A2 477 DIGOXIN DIGOXIN CHEMBL1751 inhibitor