Na/K-transporting ATPase sub. α-3

AltitudeomicsDB
Protein Official symbol ATP1A3
Aliases ATP1A3
Chromosomal Location 19
Length 1013
Uniprot ID P13637
EC number 7.2.2.13
Protein family Information(Pfam) PF00689;PF00690;
PDB id None
InterPro ID IPR006068;IPR004014;IPR023299;IPR018303;IPR023298;IPR008250;IPR036412;IPR023214;IPR005775;IPR001757;
dbSNP rs542652468 rs542652468 rs606231427 rs1396898460 rs80356532 rs80356532 rs80356533 rs879255368 rs606231428 rs606231430 rs606231433 rs80356534 rs557052809 rs557052809 rs80356535 rs534926223 rs606231437 rs606231437 rs80356536 rs80356537 rs80356537 rs549006436 rs536681257 rs387907282 rs387907281 rs587777771 rs267606670 rs267606670 rs606231444 rs398122887 rs606231446 rs606231447

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ATP1A3 ATP1B3 0.9940000000000001
ATP1A3 ATP1B1 0.99
ATP1B1 FXYD2 0.9890000000000001
ATP1B1 FXYD7 0.983
ATP1A3 ATP1B2 0.978
FXYD2 ATP1B3 0.975
ATP1A3 FXYD2 0.97
FXYD2 ATP1B2 0.9670000000000001
FXYD2 ATP1B4 0.9540000000000001
ATP1A3 ATP1B4 0.9390000000000001
ATP1A3 FXYD7 0.937
FXYD6 ATP1A3 0.9309999999999999
FXYD6 ATP1B2 0.9309999999999999
FXYD1 ATP1B1 0.9309999999999999
ATP1A3 RS1 0.924
FXYD3 ATP1B1 0.924
FXYD3 ATP1B2 0.9229999999999999
FXYD7 ATP1B2 0.922
FXYD6 ATP1B3 0.9209999999999999
FXYD3 ATP1B3 0.92
FXYD4 ATP1B1 0.915
FXYD1 ATP1A3 0.914
ATP1B1 ATP1B2 0.914
FXYD1 ATP1B2 0.9129999999999999
RS1 ATP1B2 0.9129999999999999
FXYD4 ATP1B2 0.912
FXYD3 ATP1A3 0.912
FXYD6 ATP1B1 0.912
ATP1B1 ATP1B3 0.9109999999999999
FXYD4 ATP1A3 0.9109999999999999
FXYD4 ATP1B3 0.91
FXYD1 ATP1B3 0.909
ATP1B3 FXYD7 0.9059999999999999
ATP1B3 ATP1B2 0.9059999999999999
ATP1A3 AGRN 0.905
Gene Ontology Semantic Similarity
Download Tab separated file
# 478 (ATP1A3) 481 (ATP1B1) 486 (FXYD2) 53826 (FXYD6) 5348 (FXYD1) 5349 (FXYD3) 53822 (FXYD7) 53828 (FXYD4) 6247 (RS1) 483 (ATP1B3) 482 (ATP1B2) 23439 (ATP1B4) 375790 (AGRN)
478 (ATP1A3) 1.00 0.60 0.43 0.40 0.33 0.17 0.39 0.17 0.39 0.51 0.60 0.46 0.42
481 (ATP1B1) 0.60 1.00 0.37 0.46 0.37 0.27 0.44 0.27 0.48 0.64 0.73 0.46 0.50
486 (FXYD2) 0.43 0.37 1.00 0.62 0.52 1.00 0.55 1.00 0.28 0.50 0.49 0.46 0.22
53826 (FXYD6) 0.40 0.46 0.62 1.00 0.80 1.00 0.90 1.00 0.48 0.39 0.54 0.22 0.54
5348 (FXYD1) 0.33 0.37 0.52 0.80 1.00 1.00 0.91 1.00 0.39 0.34 0.46 0.10 0.43
5349 (FXYD3) 0.17 0.27 1.00 1.00 1.00 1.00 1.00 1.00 0.17 0.27 0.27 0.10 0.21
53822 (FXYD7) 0.39 0.44 0.55 0.90 0.91 1.00 1.00 1.00 0.48 0.39 0.55 0.12 0.52
53828 (FXYD4) 0.17 0.27 1.00 1.00 1.00 1.00 1.00 1.00 0.17 0.27 0.27 0.10 0.21
6247 (RS1) 0.39 0.48 0.28 0.48 0.39 0.17 0.48 0.17 1.00 0.33 0.48 0.10 0.48
483 (ATP1B3) 0.51 0.64 0.50 0.39 0.34 0.27 0.39 0.27 0.33 1.00 0.96 0.46 0.33
482 (ATP1B2) 0.60 0.73 0.49 0.54 0.46 0.27 0.55 0.27 0.48 0.96 1.00 0.46 0.49
23439 (ATP1B4) 0.46 0.46 0.46 0.22 0.10 0.10 0.12 0.10 0.10 0.46 0.46 1.00 0.12
375790 (AGRN) 0.42 0.50 0.22 0.54 0.43 0.21 0.52 0.21 0.48 0.33 0.49 0.12 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ATP1A3 Rat Left brain cortices 300hPa 9144 m 1 hour downregulated 0.61±0.1 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT029518 hsa-miR-26b-5p Homo sapiens ATP1A3 478 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT626514 hsa-miR-8485 Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626509 hsa-miR-4286 Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626502 hsa-miR-6833-3p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626511 hsa-miR-5003-5p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626508 hsa-miR-6845-3p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626512 hsa-miR-362-3p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626505 hsa-miR-942-5p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626503 hsa-miR-4768-5p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626510 hsa-miR-181a-2-3p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626504 hsa-miR-6873-3p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626507 hsa-miR-7110-3p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626506 hsa-miR-6817-3p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT626513 hsa-miR-329-3p Homo sapiens ATP1A3 478 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
Gene Ontology
ID GO ID GO Term GO Type
478 GO:0005524 ATP binding GOTERM_MF_DIRECT
478 GO:0005634 nucleus GOTERM_CC_DIRECT
478 GO:0030007 cellular potassium ion homeostasis GOTERM_BP_DIRECT
478 GO:0060048 cardiac muscle contraction GOTERM_BP_DIRECT
478 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
478 GO:0086064 cell communication by electrical coupling involved in cardiac conduction GOTERM_BP_DIRECT
478 GO:0046872 metal ion binding GOTERM_MF_DIRECT
478 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
478 GO:0005886 plasma membrane GOTERM_CC_DIRECT
478 GO:1990239 histone methyltransferase binding GOTERM_MF_DIRECT
478 GO:0071383 cellular response to steroid hormone stimulus GOTERM_BP_DIRECT
478 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
478 GO:0005890 sodium:potassium-exchanging ATPase complex GOTERM_CC_DIRECT
478 GO:0007613 memory GOTERM_BP_DIRECT
478 GO:0036376 sodium ion export from cell GOTERM_BP_DIRECT
478 GO:1903779 regulation of cardiac conduction GOTERM_BP_DIRECT
478 GO:0008542 visual learning GOTERM_BP_DIRECT
478 GO:1903416 response to glycoside GOTERM_BP_DIRECT
478 GO:0043395 glutathione binding GOTERM_MF_DIRECT
478 GO:0035235 ionotropic glutamate receptor signaling pathway GOTERM_BP_DIRECT
478 GO:0030424 axon GOTERM_CC_DIRECT
478 GO:0000166 nucleotide binding GOTERM_MF_DIRECT
478 GO:0051087 unfolded protein binding GOTERM_MF_DIRECT
478 GO:0008344 adult locomotory behavior GOTERM_BP_DIRECT
478 GO:0010107 potassium ion import GOTERM_BP_DIRECT
478 GO:0042493 response to drug GOTERM_BP_DIRECT
478 GO:0086036 regulation of cardiac muscle cell membrane potential GOTERM_BP_DIRECT
478 GO:0031748 haptoglobin binding GOTERM_MF_DIRECT
478 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient GOTERM_BP_DIRECT
478 GO:0015991 ATP hydrolysis coupled proton transport GOTERM_BP_DIRECT
478 GO:0005391 sodium:potassium-exchanging ATPase activity GOTERM_MF_DIRECT
478 GO:0086037 protein phosphatase activator activity GOTERM_MF_DIRECT
478 GO:0006883 cellular sodium ion homeostasis GOTERM_BP_DIRECT
478 GO:0034220 ion transmembrane transport GOTERM_BP_DIRECT
478 GO:0042383 sarcolemma GOTERM_CC_DIRECT
478 GO:0044326 dendritic spine neck GOTERM_CC_DIRECT
478 GO:1903561 extracellular vesicle GOTERM_CC_DIRECT
478 GO:0044327 dendritic spine head GOTERM_CC_DIRECT
478 GO:0045202 synapse GOTERM_CC_DIRECT
478 GO:0043209 myelin sheath GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
478 hsa04024 cAMP signaling pathway
478 hsa04022 cGMP-PKG signaling pathway
478 hsa04261 Adrenergic signaling in cardiomyocytes
478 hsa04260 Cardiac muscle contraction
478 hsa04960 Aldosterone-regulated sodium reabsorption
478 hsa04961 Endocrine and other factor-regulated calcium reabsorption
478 hsa04911 Insulin secretion
478 hsa04971 Gastric acid secretion
478 hsa04919 Thyroid hormone signaling pathway
478 hsa04918 Thyroid hormone synthesis
478 hsa04978 Mineral absorption
478 hsa04974 Protein digestion and absorption
478 hsa04964 Proximal tubule bicarbonate reclamation
478 hsa04972 Pancreatic secretion
478 hsa04970 Salivary secretion
478 hsa04973 Carbohydrate digestion and absorption
478 hsa04976 Bile secretion
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ATP1A3 478 Heart Decompensation C1961112 Pathologic Function 0.3 0.58 0.379 phenotype
ATP1A3 478 Heart Failure, Right-Sided C0235527 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Dystonia, Paroxysmal C0393588 Sign or Symptom 0.3 0.58 0.379 phenotype
ATP1A3 478 Osteoarthrosis Deformans C0086743 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Dystonia, Diurnal C0393610 Sign or Symptom 0.3 0.58 0.379 phenotype
ATP1A3 478 Autosomal Dominant Juvenile Parkinson Disease C0752097 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Parkinsonism, Experimental C0752101 Experimental Model of Disease 0.3 0.58 0.379 disease
ATP1A3 478 Parkinsonian Disorders C0242422 Disease or Syndrome 0.47 0.58 0.379 group
ATP1A3 478 Congestive heart failure C0018802 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Left-Sided Heart Failure C0023212 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Autosomal Recessive Parkinsonism C0752100 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Parkinsonism, Juvenile C0752105 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Degenerative polyarthritis C0029408 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Dystonia, Limb C0751093 Sign or Symptom 0.3 0.58 0.379 phenotype
ATP1A3 478 Ventricular Dysfunction, Left C0242698 Pathologic Function 0.3 0.58 0.379 phenotype
ATP1A3 478 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE C1868675 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Heart failure C0018801 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Familial Juvenile Parkinsonism C0752104 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Ramsay Hunt Paralysis Syndrome C0242423 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Myocardial Failure C1959583 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Dystonia C0013421 Sign or Symptom 0.5 0.58 0.379 phenotype
ATP1A3 478 Autosomal Dominant Parkinsonism C0752098 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Alternating hemiplegia of childhood C0338488 Disease or Syndrome 0.6 0.58 0.379 disease
ATP1A3 478 DYSTONIA 12 C1868681 Disease or Syndrome 0.8 0.58 0.379 disease
ATP1A3 478 CAPOS syndrome C1832466 Disease or Syndrome 0.76 0.58 0.379 disease
ATP1A3 478 Parkinson Disease C0030567 Disease or Syndrome 0.32 0.58 0.379 disease
ATP1A3 478 Epileptic encephalopathy C0543888 Disease or Syndrome 0.3 0.58 0.379 disease
ATP1A3 478 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.58 0.379 group
ATP1A3 478 Ataxias, Hereditary C0004138 Disease or Syndrome 0.3 0.58 0.379 group
ATP1A3 478 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.51 0.58 0.379 disease
ATP1A3 478 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.3 0.58 0.379 disease
ATP1A3 478 Anhedonia C0178417 Mental or Behavioral Dysfunction 0.3 0.58 0.379 disease
ATP1A3 478 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.4 0.58 0.379 disease
ATP1A3 478 ALTERNATING HEMIPLEGIA OF CHILDHOOD 2 C3553788 Disease or Syndrome 0.41 0.58 0.379 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ATP1A3 478 ACETYLDIGITOXIN ACETYLDIGITOXIN CHEMBL3545057 inhibitor
ATP1A3 478 DESLANOSIDE DESLANOSIDE CHEMBL1614 inhibitor
ATP1A3 478 DIGITOXIN DIGITOXIN CHEMBL254219 inhibitor
ATP1A3 478 DIGOXIN DIGOXIN CHEMBL1751 inhibitor