Purine nucleoside phosphorylase

AltitudeomicsDB
Protein Official symbol PNP
Aliases PNP NP
Chromosomal Location  14
Length 289
Uniprot ID P00491
EC number 2.4.2.1
Protein family Information(Pfam) PF01048;
PDB id 1M73;1PF7;1PWY;1RCT;1RFG;1RR6;1RSZ;1RT9;1ULA;1ULB;1V2H;1V3Q;1V41;1V45;1YRY;2A0W;2A0X;2A0Y;2OC4;2OC9;2ON6;2Q7O;3BGS;3D1V;3GB9;3GGS;3INY;3K8O;3K8Q;3PHB;4EAR;4EB8;4ECE;4GKA;5ETJ;5UGF;
InterPro ID IPR000845;IPR035994;IPR011270;IPR011268;IPR018099;
dbSNP rs1049564 rs104894453 rs104894450 rs104894454 rs104894452 rs104894451

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ADA PNP 0.996
ADA ADK 0.995
APRT ADK 0.991
PNP ADK 0.989
CDA DCK 0.986
APRT GDA 0.984
APRT PNP 0.984
PNP GDA 0.984
APRT HPRT1 0.983
CDA TK1 0.98
NT5C3A NT5C 0.979
PNP UPP1 0.979
CDA UPP1 0.977
UPRT UPP1 0.976
CDA PNP 0.976
DPYD UPP1 0.976
PNP HPRT1 0.974
NAPRT NMRK1 0.973
ADA NT5E 0.971
NT5C2 DCK 0.968
ADK NT5E 0.968
PGM2 PNP 0.964
PNP DCK 0.963
PNP NMRK1 0.963
ADA DCK 0.962
UPP2 CDA 0.961
XDH GDA 0.959
UPRT PNP 0.958
NMRK1 NAMPT 0.958
NAPRT PNP 0.958
DPYD PNP 0.957
CECR1 PNP 0.957
NMRK2 NAPRT 0.956
CECR1 ADK 0.956
NT5C2 NT5C1A 0.956
UPP2 PNP 0.955
PNP DGUOK 0.955
UPP2 UPRT 0.953
HPRT1 GDA 0.953
NT5C3A NT5C2 0.952
XDH PNP 0.951
APRT DCK 0.949
UPP2 DPYD 0.948
UPP1 TK1 0.946
CDA NT5C2 0.945
NT5C3B NT5C1B 0.945
PNP NT5C2 0.945
CECR1 ADA 0.945
UPRT DPYD 0.944
NT5C3A NT5C1A 0.944
NT5C3B NT5C1A 0.944
NT5C NT5C1A 0.944
NT5C3A DCK 0.943
CD38 NAMPT 0.941
DCK NT5C 0.94
PNP NT5E 0.94
PNP NAMPT 0.939
BST1 NAMPT 0.939
UPP1 TK2 0.938
NT5M DCK 0.938
NMRK2 PNP 0.937
PNP TK1 0.937
NT5C2 ADK 0.937
UPP2 TK1 0.937
NNMT NAMPT 0.936
NMRK2 NAMPT 0.935
ADA NT5C2 0.935
NT5C1B NT5C 0.934
NT5M NT5C1A 0.933
DCK NT5C1A 0.932
CDA NT5E 0.932
UPP2 TK2 0.932
NT5C2 NT5C 0.932
NT5M DGUOK 0.931
NT5C1B NT5C2 0.931
CDA NT5C 0.931
XDH HPRT1 0.929
APRT NT5E 0.929
NT5M NT5C1B 0.928
TK1 TK2 0.927
NT5C3A CDA 0.927
HPRT1 NT5E 0.926
TK1 NT5C 0.926
NT5C1B DCK 0.925
PNP BST1 0.924
NNMT CD38 0.923
PNP NT5C1A 0.923
ADK NT5C1A 0.923
NT5M NT5C2 0.923
UPRT NT5E 0.922
NT5C3A NT5C1B 0.921
ADA NT5C1A 0.921
NT5C2 HPRT1 0.921
DCK NT5E 0.92
NT5C3B PNP 0.92
CDA NT5C1A 0.918
NT5C3B NT5C2 0.918
NT5C3B ADK 0.917
NT5C3A PNP 0.917
NT5C3B NT5M 0.915
NT5E NAMPT 0.915
NT5C3B DCK 0.915
ADA NT5C 0.914
PNP CD38 0.914
NNMT BST1 0.914
PNP NT5C 0.913
BST1 CD38 0.913
NT5C1B ADK 0.913
NT5C3A ADA 0.912
NNMT PNP 0.911
NT5M NT5E 0.911
APRT NT5C2 0.91
CDA TK2 0.91
NT5M ADK 0.91
NT5M ADA 0.908
NT5C3B ADA 0.907
HPRT1 NT5C1A 0.907
APRT NT5C 0.907
APRT NT5C1A 0.907
NT5M CDA 0.906
NT5C3B NAMPT 0.906
NT5C3A ADK 0.905
NT5C3A NAMPT 0.905
ADA NT5C1B 0.904
NT5M APRT 0.904
NT5M NAMPT 0.903
NT5M PNP 0.903
NAPRT NT5C 0.903
UPRT NT5C 0.903
PNP NT5C1B 0.902
ENSG00000250741 APRT 0.902
ADK NT5C 0.902
NAPRT NT5C3B 0.902
NT5C2 NAMPT 0.902
NT5C3B HPRT1 0.902
PNP TK2 0.902
APRT NT5C1B 0.902
ENSG00000250741 PNP 0.902
NAPRT NT5M 0.902
HPRT1 NT5C 0.902
NT5C3A NAPRT 0.902
NT5C3A HPRT1 0.902
NAPRT NT5C1A 0.901
NT5C NAMPT 0.9
CECR1 DCK 0.9
ENSG00000250741 NAMPT 0.9
ENSG00000250741 NAPRT 0.9
ENSG00000250741 ADA 0.9
NT5M HPRT1 0.9
NT5C3B CDA 0.9
NAPRT NT5C1B 0.9
NT5M UPRT 0.9
NAPRT NT5C2 0.9
NT5C3A APRT 0.9
NAPRT CECR1 0.9
NT5C3A NT5M 0.9
UPRT NT5C1A 0.9
NT5C3B NT5C 0.9
NT5C1B NAMPT 0.9
NT5C3A UPRT 0.9
ENSG00000250741 ADK 0.9
ENSG00000250741 CDA 0.9
NT5C1A NAMPT 0.9
ENSG00000250741 HPRT1 0.9
NT5C3B UPRT 0.9
ENSG00000250741 UPRT 0.9
CDA NT5C1B 0.9
ENSG00000250741 DCK 0.9
NT5C1B HPRT1 0.9
NT5C3B APRT 0.9
UPRT NT5C1B 0.9
NT5C3A TK1 0.9
UPRT NT5C2 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 9627 (SNCAIP) 2861 (GPR37) 5071 (PARK2) 2812 (GP1BB) 54584 (GNB1L) 5413 (SEPT5)
9627 (SNCAIP) 1.00 0.65 0.69 0.79 0.48 0.66
2861 (GPR37) 0.65 1.00 0.65 0.80 0.48 0.52
5071 (PARK2) 0.69 0.65 1.00 0.64 0.48 0.63
2812 (GP1BB) 0.79 0.80 0.64 1.00 0.48 0.60
54584 (GNB1L) 0.48 0.48 0.48 0.48 1.00 0.64
5413 (SEPT5) 0.66 0.52 0.63 0.60 0.64 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PNP Toad Liver - 3464 m 33 day upregulated 3.0933543 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
GATA2 2624 PNP 4860 proximal_filtered 22955619 TRANSFAC
USF2 7392 PNP 4860 proximal_filtered 22955619 TRANSFAC
NFE2 4778 PNP 4860 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT003765 hsa-miR-1-3p Homo sapiens PNP 4860 Homo sapiens Western blot;qRT-PCR;Microarray Functional MTI 21701775
MIRT003765 hsa-miR-1-3p Homo sapiens PNP 4860 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT003765 hsa-miR-1-3p Homo sapiens PNP 4860 Homo sapiens Microarray Functional MTI (Weak) 15685193
MIRT003765 hsa-miR-1-3p Homo sapiens PNP 4860 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 22068816
MIRT003765 hsa-miR-1-3p Homo sapiens PNP 4860 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT006571 hsa-miR-133a-3p Homo sapiens PNP 4860 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 22068816
MIRT006571 hsa-miR-133a-3p Homo sapiens PNP 4860 Homo sapiens Western blot;qRT-PCR;Microarray Functional MTI 21701775
MIRT021132 hsa-miR-186-5p Homo sapiens PNP 4860 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT022705 hsa-miR-124-3p Homo sapiens PNP 4860 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT026040 hsa-miR-196a-5p Homo sapiens PNP 4860 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT031731 hsa-miR-16-5p Homo sapiens PNP 4860 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT031731 hsa-miR-16-5p Homo sapiens PNP 4860 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT036138 hsa-miR-1296-5p Homo sapiens PNP 4860 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT783859 hsa-miR-147a Homo sapiens PNP 4860 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786029 hsa-miR-4504 Homo sapiens PNP 4860 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786837 hsa-miR-4797-5p Homo sapiens PNP 4860 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786994 hsa-miR-5010-3p Homo sapiens PNP 4860 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787382 hsa-miR-542-3p Homo sapiens PNP 4860 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787876 hsa-miR-574-5p Homo sapiens PNP 4860 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789216 hsa-miR-6867-5p Homo sapiens PNP 4860 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788940 hsa-miR-6818-5p Homo sapiens PNP 4860 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
Gene Ontology
ID GO ID GO Term GO Type
4860 GO:0034418 urate biosynthetic process GOTERM_BP_DIRECT
4860 GO:0001882 complement component C1q binding GOTERM_MF_DIRECT
4860 GO:0070970 interleukin-2 secretion GOTERM_BP_DIRECT
4860 GO:0002060 p53 binding GOTERM_MF_DIRECT
4860 GO:0005856 cytoskeleton GOTERM_CC_DIRECT
4860 GO:0043101 purine-containing compound salvage GOTERM_BP_DIRECT
4860 GO:0004731 protein tyrosine phosphatase activity GOTERM_MF_DIRECT
4860 GO:0005737 cytoplasm GOTERM_CC_DIRECT
4860 GO:0006738 nicotinamide riboside catabolic process GOTERM_BP_DIRECT
4860 GO:0009116 nucleoside metabolic process GOTERM_BP_DIRECT
4860 GO:0005622 intracellular GOTERM_CC_DIRECT
4860 GO:0005634 nucleus GOTERM_CC_DIRECT
4860 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway GOTERM_BP_DIRECT
4860 GO:0042102 positive regulation of T cell proliferation GOTERM_BP_DIRECT
4860 GO:0005829 cytosol GOTERM_CC_DIRECT
4860 GO:0005576 extracellular region GOTERM_CC_DIRECT
4860 GO:0006148 inosine catabolic process GOTERM_BP_DIRECT
4860 GO:0042278 purine nucleoside metabolic process GOTERM_BP_DIRECT
4860 GO:0046638 positive regulation of alpha-beta T cell differentiation GOTERM_BP_DIRECT
4860 GO:0003824 catalytic activity GOTERM_MF_DIRECT
4860 GO:0006195 purine nucleotide catabolic process GOTERM_BP_DIRECT
4860 GO:0006139 nucleobase-containing compound metabolic process GOTERM_BP_DIRECT
4860 GO:0006955 immune response GOTERM_BP_DIRECT
4860 GO:0042301 MHC class I protein binding GOTERM_MF_DIRECT
4860 GO:0042493 response to drug GOTERM_BP_DIRECT
4860 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
4860 GO:0008144 drug binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
4860 hsa00240 Pyrimidine metabolism
4860 hsa00230 Purine metabolism
4860 hsa00760 Nicotinate and nicotinamide metabolism
4860 hsa01100 Metabolic pathways
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PNP 4860 Osteoporosis C0029456 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Arsenic Poisoning, Inorganic C0274861 Injury or Poisoning 0.3 0.545 0.793 disease
PNP 4860 Arsenic Encephalopathy C0751851 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Arsenic Induced Polyneuropathy C0751852 Injury or Poisoning 0.3 0.545 0.793 disease
PNP 4860 Nervous System, Organic Arsenic Poisoning C0274862 Injury or Poisoning 0.3 0.545 0.793 disease
PNP 4860 Osteoporosis, Senile C0029459 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Post-Traumatic Osteoporosis C0751406 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Arsenic Poisoning C0311375 Injury or Poisoning 0.3 0.545 0.793 disease
PNP 4860 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Osteoporosis, Age-Related C0001787 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.545 0.793 disease
PNP 4860 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.545 0.793 disease
PNP 4860 Purine-nucleoside phosphorylase deficiency C0268125 Disease or Syndrome 0.93 0.545 0.793 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
PNP 4860 FORODESINE FORODESINE CHEMBL218291 None
PNP 4860 FORODESINE HYDROCHLORIDE FORODESINE HYDROCHLORIDE CHEMBL550755 inhibitor
PNP 4860 FORODESINE FORODESINE CHEMBL218291 inhibitor
PNP 4860 ULODESINE ULODESINE CHEMBL269864 None