Tumor necrosis factor+C348:C358

AltitudeomicsDB
Protein Official symbol SEPT5
Aliases SEPTIN5 PNUTL1 SEPT5
Chromosomal Location  22
Length 369
Uniprot ID Q99719
EC number None
Protein family Information(Pfam) PF00735;
PDB id None
InterPro ID IPR030379;IPR027417;IPR030647;IPR016491;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PARK2 SNCAIP 0.976
PARK2 GPR37 0.969
SEPT5 PARK2 0.797
SEPT5 GP1BB 0.771
SEPT5 SNCAIP 0.736
SEPT5 GPR37 0.728
GP1BB GNB1L 0.711
SEPT5 GNB1L 0.711
GPR37 SNCAIP 0.702
Gene Ontology Semantic Similarity
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# 9627 (SNCAIP) 2861 (GPR37) 5071 (PARK2) 2812 (GP1BB) 54584 (GNB1L) 5413 (SEPT5)
9627 (SNCAIP) 1.00 0.65 0.69 0.79 0.48 0.66
2861 (GPR37) 0.65 1.00 0.65 0.80 0.48 0.52
5071 (PARK2) 0.69 0.65 1.00 0.64 0.48 0.63
2812 (GP1BB) 0.79 0.80 0.64 1.00 0.48 0.60
54584 (GNB1L) 0.48 0.48 0.48 0.48 1.00 0.64
5413 (SEPT5) 0.66 0.52 0.63 0.60 0.64 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
SEPT5 Human Blood - 3650 m 48 hours upregulated 1.499 Microarray Himalayas Indians 1 HAPE Pateints Vs Normal http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT716400 hsa-miR-5587-3p Homo sapiens SEPT5 5413 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT716399 hsa-miR-4532 Homo sapiens SEPT5 5413 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT716398 hsa-miR-4290 Homo sapiens SEPT5 5413 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT716401 hsa-miR-1825 Homo sapiens SEPT5 5413 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT716402 hsa-miR-371b-3p Homo sapiens SEPT5 5413 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
Gene Ontology
ID GO ID GO Term GO Type
5413 GO:0005938 cell cortex GOTERM_CC_DIRECT
5413 GO:0003924 GTPase activity GOTERM_MF_DIRECT
5413 GO:0043195 terminal bouton GOTERM_CC_DIRECT
5413 GO:0005198 structural molecule activity GOTERM_MF_DIRECT
5413 GO:0017157 regulation of exocytosis GOTERM_BP_DIRECT
5413 GO:0005856 cytoskeleton GOTERM_CC_DIRECT
5413 GO:0000910 cytokinesis GOTERM_BP_DIRECT
5413 GO:0016080 synaptic vesicle targeting GOTERM_BP_DIRECT
5413 GO:0005525 GTP binding GOTERM_MF_DIRECT
5413 GO:0008021 synaptic vesicle GOTERM_CC_DIRECT
5413 GO:0005515 protein binding GOTERM_MF_DIRECT
5413 GO:2000300 regulation of synaptic vesicle exocytosis GOTERM_BP_DIRECT
5413 GO:0005886 plasma membrane GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5413 hsa05012 Parkinson's disease
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
38596 5413 Degenerative Diseases, Central Nervous System C0270715 Disease or Syndrome 0.3 0.707 0.414 group
38596 5413 Degenerative Diseases, Spinal Cord C0751733 Disease or Syndrome 0.3 0.707 0.414 disease
38596 5413 Neurodegenerative Disorders C0524851 Disease or Syndrome 0.3 0.707 0.414 group
38596 5413 Respiratory Distress Syndrome, Adult C0035222 Disease or Syndrome 0.3 0.707 0.414 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types