Pyridoxal phosphate phosphatase
AltitudeomicsDB
| Protein Official symbol |
PHOSPHO2 |
| Aliases |
PHOSPHO2 |
| Chromosomal Location |
2 |
| Length |
241 |
| Uniprot ID |
Q8TCD6 |
| EC number |
3.1.3.74 |
| Protein family Information(Pfam) |
PF06888; |
| PDB id |
None |
| InterPro ID |
IPR036412;IPR023214;IPR016965;IPR006384; |
| dbSNP |
rs56036676 |
AltitudeomicsDB
| Protein 1 |
Protein 2 |
Combine Score |
| PDXK |
PNPO |
0.99 |
| PHOSPHO2 |
PNPO |
0.952 |
| AOX1 |
PNPO |
0.908 |
| AOX1 |
PDXK |
0.907 |
| PHOSPHO2 |
PDXK |
0.902 |
| PHOSPHO2 |
AOX1 |
0.9 |
Association with High Altitude
| Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
| PHOSPHO2 |
Toad |
Heart |
- |
3464 m |
33 day |
upregulated |
2.08341362 |
RNA-seq |
Tibetan Plateau |
Asiatic toad |
1 |
Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - |
28673260 |
Association with TF
| TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
Association with miRNA
| miRTarBase ID |
miRNA |
Species (miRNA) |
Protein Official Symbol |
Human Entrez ID |
Species (Target Gene) |
Experiments |
Support Type |
References (PMID) |
| MIRT030418 |
hsa-miR-24-3p |
Homo sapiens |
PHOSPHO2 |
493911 |
Homo sapiens |
Microarray |
Functional MTI (Weak) |
19748357 |
Gene Ontology
| ID |
GO ID |
GO Term |
GO Type |
| 493911 |
GO:0016311 |
dephosphorylation |
GOTERM_BP_DIRECT |
| 493911 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
| 493911 |
GO:0016791 |
phosphatase activity |
GOTERM_MF_DIRECT |
| 493911 |
GO:0033883 |
histone demethylase activity |
GOTERM_MF_DIRECT |
| 493911 |
GO:0046872 |
metal ion binding |
GOTERM_MF_DIRECT |
Pathways
| Human Entrez ID |
KEGG ID |
KEGG Term |
| 493911 |
hsa00750 |
Vitamin B6 metabolism |
| 493911 |
hsa01100 |
Metabolic pathways |
Association with Disease
| Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
Association with Drug
| Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |