Peroxiredoxin-1 (Fragment)

AltitudeomicsDB
Protein Official symbol PRDX1
Aliases PRDX1 PAGA PAGB TDPX2
Chromosomal Location  1
Length 199
Uniprot ID Q06830
EC number 1.11.1.24
Protein family Information(Pfam) PF10417;PF00578;
PDB id 2RII;3HY2;4XCS;
InterPro ID IPR000866;IPR024706;IPR019479;IPR036249;IPR013766;
dbSNP rs34034070

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CDK5 CDK5R1 0.992
TXN PRDX1 0.987
CDK5 TP53 0.978
PRDX1 SESN2 0.974
TP53 SESN2 0.974
TXN TP53 0.972
AR PRDX1 0.951
TP53 PRDX1 0.938
SESN3 PRDX1 0.935
SESN3 TP53 0.933
CDK5R1 TP53 0.915
CDK5 PRDX1 0.912
SESN3 SESN2 0.903
CDK5R1 PRDX1 0.9
Gene Ontology Semantic Similarity
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# 1020 (CDK5) 7295 (TXN) 5052 (PRDX1) 7157 (TP53) 367 (AR) 143686 (SESN3) 8851 (CDK5R1) 83667 (SESN2)
1020 (CDK5) 1.00 0.42 0.44 0.47 0.47 0.45 0.70 0.43
7295 (TXN) 0.42 1.00 0.72 0.56 0.57 0.57 0.48 0.51
5052 (PRDX1) 0.44 0.72 1.00 0.55 0.55 0.68 0.52 0.67
7157 (TP53) 0.47 0.56 0.55 1.00 0.81 0.51 0.53 0.50
367 (AR) 0.47 0.57 0.55 0.81 1.00 0.50 0.48 0.49
143686 (SESN3) 0.45 0.57 0.68 0.51 0.50 1.00 0.50 0.93
8851 (CDK5R1) 0.70 0.48 0.52 0.53 0.48 0.50 1.00 0.48
83667 (SESN2) 0.43 0.51 0.67 0.50 0.49 0.93 0.48 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PRDX1 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
TAF1 6872 PRDX1 5052 proximal_filtered 22955619 TRANSFAC
TBP 6908 PRDX1 5052 proximal_filtered 22955619 TRANSFAC
BRCA1 672 PRDX1 5052 proximal_filtered 22955619 TRANSFAC
GTF2B 2959 PRDX1 5052 proximal_filtered 22955619 TRANSFAC
ETS1 2113 PRDX1 5052 proximal_filtered 22955619 TRANSFAC
ZBTB33 10009 PRDX1 5052 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT019836 hsa-miR-375 Homo sapiens PRDX1 5052 Homo sapiens Microarray Functional MTI (Weak) 20215506
MIRT025797 hsa-miR-7-5p Homo sapiens PRDX1 5052 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT036544 hsa-miR-1225-3p Homo sapiens PRDX1 5052 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT040747 hsa-miR-18a-3p Homo sapiens PRDX1 5052 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT041864 hsa-miR-484 Homo sapiens PRDX1 5052 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046315 hsa-miR-23b-3p Homo sapiens PRDX1 5052 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048535 hsa-miR-100-5p Homo sapiens PRDX1 5052 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT438052 hsa-miR-510-5p Homo sapiens PRDX1 5052 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 23971998
Gene Ontology
ID GO ID GO Term GO Type
5052 GO:0042267 natural killer cell mediated cytotoxicity GOTERM_BP_DIRECT
5052 GO:0098609 cell-cell adhesion GOTERM_BP_DIRECT
5052 GO:0042345 regulation of NF-kappaB import into nucleus GOTERM_BP_DIRECT
5052 GO:0016209 antioxidant activity GOTERM_MF_DIRECT
5052 GO:0045454 cell redox homeostasis GOTERM_BP_DIRECT
5052 GO:0005739 mitochondrion GOTERM_CC_DIRECT
5052 GO:0005829 cytosol GOTERM_CC_DIRECT
5052 GO:0042470 melanosome GOTERM_CC_DIRECT
5052 GO:0032872 regulation of stress-activated MAPK cascade GOTERM_BP_DIRECT
5052 GO:0051920 Hsp90 protein binding GOTERM_MF_DIRECT
5052 GO:0031012 extracellular matrix GOTERM_CC_DIRECT
5052 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
5052 GO:0004601 peroxidase activity GOTERM_MF_DIRECT
5052 GO:0005515 protein binding GOTERM_MF_DIRECT
5052 GO:0008379 acetylglucosaminyltransferase activity GOTERM_MF_DIRECT
5052 GO:0005623 cell GOTERM_CC_DIRECT
5052 GO:0005634 nucleus GOTERM_CC_DIRECT
5052 GO:0019430 removal of superoxide radicals GOTERM_BP_DIRECT
5052 GO:0005737 cytoplasm GOTERM_CC_DIRECT
5052 GO:0034101 erythrocyte homeostasis GOTERM_BP_DIRECT
5052 GO:0042802 identical protein binding GOTERM_MF_DIRECT
5052 GO:0098641 cadherin binding involved in cell-cell adhesion GOTERM_MF_DIRECT
5052 GO:0001501 skeletal system development GOTERM_BP_DIRECT
5052 GO:0016491 oxidoreductase activity GOTERM_MF_DIRECT
5052 GO:0005913 cell-cell adherens junction GOTERM_CC_DIRECT
5052 GO:0043209 myelin sheath GOTERM_CC_DIRECT
5052 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
5052 GO:0042744 hydrogen peroxide catabolic process GOTERM_BP_DIRECT
5052 GO:0000302 response to reactive oxygen species GOTERM_BP_DIRECT
5052 GO:0001895 retina homeostasis GOTERM_BP_DIRECT
5052 GO:0008283 cell proliferation GOTERM_BP_DIRECT
5052 GO:0005615 extracellular space GOTERM_CC_DIRECT
5052 GO:0044822 poly GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5052 hsa04146 Peroxisome
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PRDX1 5052 Lung Neoplasms C0024121 Neoplastic Process 0.32 0.577 0.69 group
PRDX1 5052 Methylmalonic acidemia with homocystinuria C1848561 Disease or Syndrome 0.4 0.577 0.69 disease
PRDX1 5052 Hepatoma, Novikoff C0019208 Experimental Model of Disease; Neoplastic Process 0.3 0.577 0.69 disease
PRDX1 5052 Keloid C0022548 Acquired Abnormality 0.3 0.577 0.69 phenotype
PRDX1 5052 Malignant neoplasm of lung C0242379 Neoplastic Process 0.36 0.577 0.69 disease
PRDX1 5052 Pulmonary Fibrosis - from Asbestos Exposure C2930617 Disease or Syndrome 0.3 0.577 0.69 disease
PRDX1 5052 Hepatoma, Morris C0019207 Experimental Model of Disease; Neoplastic Process 0.3 0.577 0.69 disease
PRDX1 5052 Liver Neoplasms, Experimental C0023904 Experimental Model of Disease; Neoplastic Process 0.3 0.577 0.69 group
PRDX1 5052 Squamous cell carcinoma of esophagus C0279626 Neoplastic Process 0.32 0.577 0.69 disease
PRDX1 5052 Non-Small Cell Lung Carcinoma C0007131 Neoplastic Process 0.31 0.577 0.69 disease
PRDX1 5052 Schistosomiasis C0036323 Disease or Syndrome 0.3 0.577 0.69 disease
PRDX1 5052 Liver carcinoma C2239176 Neoplastic Process 0.34 0.577 0.69 disease
PRDX1 5052 Asbestosis C0003949 Disease or Syndrome 0.3 0.577 0.69 disease
PRDX1 5052 Experimental Hepatoma C0086404 Experimental Model of Disease; Neoplastic Process 0.3 0.577 0.69 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
PRDX1 5052 ANTIOXIDANT None None None
PRDX1 5052 HYDROGEN PEROXIDE HYDROGEN PEROXIDE CHEMBL71595 None