Mitochondrial fission 1 protein
AltitudeomicsDB
| Protein Official symbol |
FIS1 |
| Aliases |
FIS1 TTC11 CGI-135 |
| Chromosomal Location |
7 |
| Length |
152 |
| Uniprot ID |
Q9Y3D6 |
| EC number |
None |
| Protein family Information(Pfam) |
PF14853;PF14852; |
| PDB id |
1NZN;1PC2; |
| InterPro ID |
IPR016543;IPR033745;IPR028061;IPR028058;IPR011990; |
| dbSNP |
None |
AltitudeomicsDB
| Protein 1 |
Protein 2 |
Combine Score |
| DNM1L |
FIS1 |
0.985 |
| DNM1L |
MFN2 |
0.975 |
| MFN1 |
OPA1 |
0.975 |
| TBC1D15 |
FIS1 |
0.971 |
| MFN1 |
FIS1 |
0.97 |
| OPA1 |
MFN2 |
0.9640000000000001 |
| TBC1D15 |
TBC1D17 |
0.9640000000000001 |
| MFN2 |
FIS1 |
0.961 |
| DNM1L |
MFN1 |
0.9590000000000001 |
| OPA1 |
FIS1 |
0.951 |
| MFN1 |
MFN2 |
0.9470000000000001 |
| DNM1 |
FIS1 |
0.9359999999999999 |
| MIEF1 |
FIS1 |
0.9309999999999999 |
| PEX11A |
FIS1 |
0.9229999999999999 |
| FIS1 |
TBC1D17 |
0.9109999999999999 |
Gene Ontology Semantic Similarity
Download Tab separated file
| # |
10059 (DNM1L) |
55669 (MFN1) |
64786 (TBC1D15) |
4976 (OPA1) |
9927 (MFN2) |
1759 (DNM1) |
54471 (MIEF1) |
8800 (PEX11A) |
51024 (FIS1) |
79735 (TBC1D17) |
|
10059 (DNM1L)
|
1.00
|
0.72
|
0.79
|
0.75
|
0.78
|
0.76
|
0.55
|
0.67
|
0.61
|
0.79
|
|
55669 (MFN1)
|
0.72
|
1.00
|
0.55
|
0.81
|
0.92
|
0.79
|
0.55
|
0.68
|
0.74
|
0.55
|
|
64786 (TBC1D15)
|
0.79
|
0.55
|
1.00
|
0.52
|
0.56
|
0.56
|
0.54
|
0.65
|
0.69
|
1.00
|
|
4976 (OPA1)
|
0.75
|
0.81
|
0.52
|
1.00
|
0.78
|
0.81
|
0.52
|
0.60
|
0.63
|
0.52
|
|
9927 (MFN2)
|
0.78
|
0.92
|
0.56
|
0.78
|
1.00
|
0.77
|
0.56
|
0.67
|
0.71
|
0.56
|
|
1759 (DNM1)
|
0.76
|
0.79
|
0.56
|
0.81
|
0.77
|
1.00
|
0.61
|
0.65
|
0.65
|
0.56
|
|
54471 (MIEF1)
|
0.55
|
0.55
|
0.54
|
0.52
|
0.56
|
0.61
|
1.00
|
0.65
|
0.66
|
0.54
|
|
8800 (PEX11A)
|
0.67
|
0.68
|
0.65
|
0.60
|
0.67
|
0.65
|
0.65
|
1.00
|
0.86
|
0.65
|
|
51024 (FIS1)
|
0.61
|
0.74
|
0.69
|
0.63
|
0.71
|
0.65
|
0.66
|
0.86
|
1.00
|
0.69
|
|
79735 (TBC1D17)
|
0.79
|
0.55
|
1.00
|
0.52
|
0.56
|
0.56
|
0.54
|
0.65
|
0.69
|
1.00
|
Association with High Altitude
| Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
| FIS1 |
Rat |
Left brain cortices |
300hPa |
9144 m |
1 hour |
downregulated |
0.90±0.2 |
TMT labeled LTQ orbitrap |
Southwestern europe |
Male wistar rats |
1 |
Adult male Wistar rats weighing 350 g |
28697276 |
Association with TF
| TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
| GATA1 |
2623 |
FIS1 |
51024 |
proximal_filtered |
22955619 |
TRANSFAC |
Association with miRNA
| miRTarBase ID |
miRNA |
Species (miRNA) |
Protein Official Symbol |
Human Entrez ID |
Species (Target Gene) |
Experiments |
Support Type |
References (PMID) |
| MIRT006714 |
hsa-miR-484 |
Homo sapiens |
FIS1 |
51024 |
Homo sapiens |
ChIP-seq//Immunoblot//LacZ reporter assay//qRT-PCR |
Functional MTI |
22510686 |
| MIRT041016 |
hsa-miR-505-3p |
Homo sapiens |
FIS1 |
51024 |
Homo sapiens |
CLASH |
Functional MTI (Weak) |
23622248 |
Gene Ontology
| ID |
GO ID |
GO Term |
GO Type |
| 51024 |
GO:0000266 |
mitochondrial fission |
GOTERM_BP_DIRECT |
| 51024 |
GO:0006626 |
protein targeting to mitochondrion |
GOTERM_BP_DIRECT |
| 51024 |
GO:0008053 |
mitochondrial fusion |
GOTERM_BP_DIRECT |
| 51024 |
GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
GOTERM_BP_DIRECT |
| 51024 |
GO:0043653 |
mitochondrial fragmentation involved in apoptotic process |
GOTERM_BP_DIRECT |
| 51024 |
GO:0032471 |
negative regulation of endoplasmic reticulum calcium ion concentration |
GOTERM_BP_DIRECT |
| 51024 |
GO:0010821 |
regulation of mitochondrion organization |
GOTERM_BP_DIRECT |
| 51024 |
GO:0016559 |
peroxisome fission |
GOTERM_BP_DIRECT |
| 51024 |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
GOTERM_BP_DIRECT |
| 51024 |
GO:0001836 |
release of cytochrome c from mitochondria |
GOTERM_BP_DIRECT |
| 51024 |
GO:0035584 |
calcium-mediated signaling using intracellular calcium source |
GOTERM_BP_DIRECT |
| 51024 |
GO:0000422 |
mitophagy |
GOTERM_BP_DIRECT |
| 51024 |
GO:0031307 |
integral component of mitochondrial outer membrane |
GOTERM_CC_DIRECT |
| 51024 |
GO:0005783 |
endoplasmic reticulum |
GOTERM_CC_DIRECT |
| 51024 |
GO:0005739 |
mitochondrion |
GOTERM_CC_DIRECT |
| 51024 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
| 51024 |
GO:0051260 |
protein homooligomerization |
GOTERM_BP_DIRECT |
| 51024 |
GO:0070584 |
mitochondrion morphogenesis |
GOTERM_BP_DIRECT |
| 51024 |
GO:0090141 |
positive regulation of mitochondrial fission |
GOTERM_BP_DIRECT |
| 51024 |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
GOTERM_BP_DIRECT |
| 51024 |
GO:0051561 |
positive regulation of mitochondrial calcium ion concentration |
GOTERM_BP_DIRECT |
| 51024 |
GO:0005102 |
receptor binding |
GOTERM_MF_DIRECT |
| 51024 |
GO:0016020 |
membrane |
GOTERM_CC_DIRECT |
| 51024 |
GO:0043234 |
protein complex |
GOTERM_CC_DIRECT |
| 51024 |
GO:0090314 |
positive regulation of protein targeting to membrane |
GOTERM_BP_DIRECT |
| 51024 |
GO:0005777 |
peroxisome |
GOTERM_CC_DIRECT |
| 51024 |
GO:0005779 |
integral component of peroxisomal membrane |
GOTERM_CC_DIRECT |
Pathways
| Human Entrez ID |
KEGG ID |
KEGG Term |
Association with Disease
| Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
| FIS1 |
51024 |
Ceroid lipofuscinosis, neuronal 1, infantile |
C2931673 |
Disease or Syndrome |
0.3 |
0.752 |
0.448 |
disease |
Association with Drug
| Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |