Bridging integrator 2 (Fragment)

AltitudeomicsDB
Protein Official symbol BIN2
Aliases BIN2 BRAP1
Chromosomal Location 12
Length 565
Uniprot ID Q9UBW5
EC number None
Protein family Information(Pfam) PF03114;
PDB id 4AVM;4I1Q;
InterPro ID IPR027267;IPR003005;IPR004148;
dbSNP rs7312857 rs7954976

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
EPS15 AP2A1 0.995
AP2A1 AP2M1 0.992
SYNJ1 EPS15 0.992
PICALM BIN1 0.99
EPN1 EPS15 0.984
EPN1 AP2A1 0.979
SYNJ1 DNM1 0.974
LCP1 FSCN1 0.972
DNM1 EPS15 0.968
SYNJ1 PICALM 0.965
EPS15 AP2M1 0.964
PICALM EPS15 0.963
EPS15 BIN1 0.954
EPN1 AP2M1 0.953
SYNJ1 AP2A1 0.952
EPN1 PICALM 0.952
DNM1 BIN1 0.951
LCP1 GSN 0.95
LCP1 BIN2 0.947
PICALM SYNJ2 0.945
SYNJ1 BIN1 0.943
PICALM AP2A1 0.942
DNM1 AP2A1 0.941
EPN1 DNM1 0.941
EPS15 SYNJ2 0.94
PICALM AP2M1 0.939
FSCN1 GSN 0.938
PICALM DNM1 0.937
BIN3 BIN2 0.936
SYNJ1 EPN1 0.936
SYNJ2 BIN1 0.936
EPN1 BIN1 0.935
DNM1 SYNJ2 0.934
DNM1 AP2M1 0.93
SYNJ2 AP2M1 0.929
GSN SH3PXD2A 0.929
EPN1 SYNJ2 0.928
SYNJ2 BIN2 0.923
SYNJ1 AP2M1 0.923
AP2A1 SYNJ2 0.923
SYNJ1 BIN2 0.923
FSCN1 SH3PXD2A 0.923
EPS15 BIN2 0.921
PPP3CB DNM1 0.92
PPP3CA DNM1 0.919
BIN1 BIN2 0.915
EPN1 BIN2 0.915
AP2A1 BIN1 0.914
LPXN LCP1 0.914
DNM1 BIN2 0.913
LPXN GSN 0.912
PPP3CB AP2A1 0.912
PICALM BIN2 0.911
PPP3CC DNM1 0.911
LPXN BIN2 0.91
PPP3CA PICALM 0.91
PPP3CB PICALM 0.91
PPP3CA AP2A1 0.91
PPP3CC BIN1 0.91
SYNJ1 PPP3CB 0.91
PPP3CC AP2A1 0.91
PPP3CB BIN1 0.909
PPP3CA BIN1 0.909
PPP3CB EPS15 0.908
PPP3CB BIN2 0.908
PPP3CC PICALM 0.907
PPP3CC BIN2 0.907
BIN1 AP2M1 0.906
AP2M1 BIN2 0.906
AP2A1 BIN2 0.906
SYNJ1 SYNJ2 0.905
PPP3CB AP2M1 0.904
PPP3CC PPP3CA 0.904
PPP3CA PPP3CB 0.904
PPP3CC PPP3CB 0.903
PPP3CA BIN2 0.903
PPP3CC EPS15 0.903
SH3PXD2A KIF9 0.903
PPP3CA EPS15 0.903
SYNJ1 PPP3CC 0.902
LPXN SH3PXD2A 0.902
PPP3CA SYNJ2 0.902
PPP3CC SYNJ2 0.902
PPP3CA AP2M1 0.902
LCP1 SH3PXD2A 0.902
GSN BIN2 0.902
SYNJ1 PPP3CA 0.902
PPP3CC AP2M1 0.902
PPP3CB SYNJ2 0.902
LCP1 KIF9 0.901
LPXN KIF9 0.901
EPN1 PPP3CA 0.9
EPN1 PPP3CC 0.9
FSCN1 KIF9 0.9
EPN1 PPP3CB 0.9
GSN KIF9 0.9
FSCN1 BIN2 0.9
SH3PXD2A BIN2 0.9
LPXN FSCN1 0.9
KIF9 BIN2 0.9
Gene Ontology Semantic Similarity
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# 2060 (EPS15) 160 (AP2A1) 8867 (SYNJ1) 8301 (PICALM) 29924 (EPN1) 3936 (LCP1) 1759 (DNM1) 6624 (FSCN1) 55909 (BIN3) 8871 (SYNJ2) 2934 (GSN) 5532 (PPP3CB) 5530 (PPP3CA) 274 (BIN1) 9404 (LPXN) 5533 (PPP3CC) 1173 (AP2M1) 9644 (SH3PXD2A) 64147 (KIF9)
2060 (EPS15) 1.00 0.72 0.25 0.71 1.00 0.55 0.64 0.75 0.77 0.40 0.71 0.62 0.61 0.72 0.70 0.70 0.66 0.64 0.61
160 (AP2A1) 0.72 1.00 0.26 0.71 1.00 0.54 0.69 0.66 0.72 0.40 0.67 0.62 0.60 0.71 0.66 0.66 0.82 0.61 0.59
8867 (SYNJ1) 0.25 0.26 1.00 0.29 0.69 0.20 0.29 0.27 0.24 0.93 0.25 0.50 0.50 0.32 0.22 0.45 0.29 0.22 0.28
8301 (PICALM) 0.71 0.71 0.29 1.00 1.00 0.53 0.60 0.67 0.65 0.45 0.63 0.60 0.59 0.80 0.62 0.62 0.68 0.72 0.58
29924 (EPN1) 1.00 1.00 0.69 1.00 1.00 0.69 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
3936 (LCP1) 0.55 0.54 0.20 0.53 0.69 1.00 0.53 0.68 0.57 0.32 0.80 0.59 0.57 0.66 0.51 0.51 0.48 0.49 0.50
1759 (DNM1) 0.64 0.69 0.29 0.60 1.00 0.53 1.00 0.74 0.62 0.42 0.61 0.59 0.58 0.70 0.58 0.60 0.60 0.55 0.80
6624 (FSCN1) 0.75 0.66 0.27 0.67 1.00 0.68 0.74 1.00 0.68 0.42 0.73 0.66 0.66 0.75 0.63 0.64 0.63 0.60 0.61
55909 (BIN3) 0.77 0.72 0.24 0.65 1.00 0.57 0.62 0.68 1.00 0.37 0.70 0.61 0.60 0.73 0.69 0.70 0.66 0.62 0.59
8871 (SYNJ2) 0.40 0.40 0.93 0.45 1.00 0.32 0.42 0.42 0.37 1.00 0.40 0.62 0.61 0.49 0.34 0.55 0.43 0.34 0.40
2934 (GSN) 0.71 0.67 0.25 0.63 1.00 0.80 0.61 0.73 0.70 0.40 1.00 0.70 0.69 0.72 0.64 0.65 0.63 0.60 0.58
5532 (PPP3CB) 0.62 0.62 0.50 0.60 1.00 0.59 0.59 0.66 0.61 0.62 0.70 1.00 0.96 0.66 0.58 0.83 0.60 0.56 0.60
5530 (PPP3CA) 0.61 0.60 0.50 0.59 1.00 0.57 0.58 0.66 0.60 0.61 0.69 0.96 1.00 0.65 0.57 0.81 0.62 0.54 0.58
274 (BIN1) 0.72 0.71 0.32 0.80 1.00 0.66 0.70 0.75 0.73 0.49 0.72 0.66 0.65 1.00 0.69 0.69 0.68 0.75 0.66
9404 (LPXN) 0.70 0.66 0.22 0.62 1.00 0.51 0.58 0.63 0.69 0.34 0.64 0.58 0.57 0.69 1.00 0.63 0.62 0.55 0.54
5533 (PPP3CC) 0.70 0.66 0.45 0.62 1.00 0.51 0.60 0.64 0.70 0.55 0.65 0.83 0.81 0.69 0.63 1.00 0.63 0.58 0.57
1173 (AP2M1) 0.66 0.82 0.29 0.68 1.00 0.48 0.60 0.63 0.66 0.43 0.63 0.60 0.62 0.68 0.62 0.63 1.00 0.58 0.58
9644 (SH3PXD2A) 0.64 0.61 0.22 0.72 1.00 0.49 0.55 0.60 0.62 0.34 0.60 0.56 0.54 0.75 0.55 0.58 0.58 1.00 0.51
64147 (KIF9) 0.61 0.59 0.28 0.58 1.00 0.50 0.80 0.61 0.59 0.40 0.58 0.60 0.58 0.66 0.54 0.57 0.58 0.51 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
BIN2 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 BIN2 51411 distal 22955619 TRANSFAC
SPI1 6688 BIN2 51411 distal 22955619 TRANSFAC
NRF1 4899 BIN2 51411 distal 22955619 TRANSFAC
EBF1 1879 BIN2 51411 distal 22955619 TRANSFAC
CTCF 10664 BIN2 51411 distal 22955619 TRANSFAC
JUND 3727 BIN2 51411 distal 22955619 TRANSFAC
TBP 6908 BIN2 51411 distal 22955619 TRANSFAC
NANOG 79923 BIN2 51411 distal 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
51411 GO:0005515 protein binding GOTERM_MF_DIRECT
51411 GO:0060326 cell chemotaxis GOTERM_BP_DIRECT
51411 GO:0005543 phospholipid binding GOTERM_MF_DIRECT
51411 GO:0001891 phagocytic cup GOTERM_CC_DIRECT
51411 GO:0042995 cell projection GOTERM_CC_DIRECT
51411 GO:0006911 phagocytosis GOTERM_BP_DIRECT
51411 GO:0071800 podosome assembly GOTERM_BP_DIRECT
51411 GO:0030054 cell junction GOTERM_CC_DIRECT
51411 GO:0002102 podosome GOTERM_CC_DIRECT
51411 GO:0097320 membrane tubulation GOTERM_BP_DIRECT
51411 GO:0005938 cell cortex GOTERM_CC_DIRECT
51411 GO:0005737 cytoplasm GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types