Plastin-2

AltitudeomicsDB
Protein Official symbol LCP1
Aliases LCP1 PLS2
Chromosomal Location  13
Length 627
Uniprot ID P13796
EC number None
Protein family Information(Pfam) PF00307;PF13499;
PDB id 2D85;5JOJ;5JOL;
InterPro ID IPR001589;IPR001715;IPR036872;IPR011992;IPR018247;IPR002048;IPR039959;IPR039956;
dbSNP rs4941543 rs17067725

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
LCP1 FSCN1 0.972
LCP1 GSN 0.95
LCP1 BIN2 0.947
FSCN1 GSN 0.938
GSN SH3PXD2A 0.929
FSCN1 SH3PXD2A 0.923
LPXN LCP1 0.914
LPXN GSN 0.912
LCP1 SPI1 0.911
LPXN BIN2 0.91
LCP1 STAT4 0.904
SH3PXD2A KIF9 0.903
LPXN SH3PXD2A 0.902
GSN BIN2 0.902
LCP1 SH3PXD2A 0.902
LPXN KIF9 0.901
LCP1 KIF9 0.901
LPXN FSCN1 0.9
SH3PXD2A BIN2 0.9
GSN KIF9 0.9
KIF9 BIN2 0.9
FSCN1 KIF9 0.9
FSCN1 BIN2 0.9
LCP1 FERMT3 0.847
DBNL LCP1 0.843
LPXN FERMT3 0.812
FERMT3 BIN2 0.799
DBNL BIN2 0.781
DBNL GSN 0.781
DBNL FERMT3 0.761
GSN FERMT3 0.747
FSCN1 FERMT3 0.743
SH3PXD2A FERMT3 0.729
DBNL SH3PXD2A 0.728
LPXN DBNL 0.723
DBNL FSCN1 0.721
KIF9 FERMT3 0.72
DBNL KIF9 0.72
FERMT3 SPI1 0.455
Gene Ontology Semantic Similarity
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# 3936 (LCP1) 6624 (FSCN1) 2934 (GSN) 9404 (LPXN) 9644 (SH3PXD2A) 64147 (KIF9) 28988 (DBNL) 83706 (FERMT3) 51411 (BIN2) 6688 (SPI1) 6775 (STAT4)
3936 (LCP1) 1.00 0.68 0.80 0.51 0.49 0.50 0.70 1.00 0.55 0.39 0.48
6624 (FSCN1) 0.68 1.00 0.73 0.63 0.60 0.61 0.83 0.54 0.65 0.54 0.61
2934 (GSN) 0.80 0.73 1.00 0.64 0.60 0.58 0.73 0.50 0.68 0.50 0.62
9404 (LPXN) 0.51 0.63 0.64 1.00 0.55 0.54 0.62 0.50 0.65 0.46 0.58
9644 (SH3PXD2A) 0.49 0.60 0.60 0.55 1.00 0.51 0.74 0.50 0.79 0.44 0.55
64147 (KIF9) 0.50 0.61 0.58 0.54 0.51 1.00 0.60 0.54 0.56 0.46 0.54
28988 (DBNL) 0.70 0.83 0.73 0.62 0.74 0.60 1.00 0.54 0.64 0.50 0.60
83706 (FERMT3) 1.00 0.54 0.50 0.50 0.50 0.54 0.54 1.00 0.50 0.50 0.50
51411 (BIN2) 0.55 0.65 0.68 0.65 0.79 0.56 0.64 0.50 1.00 0.47 0.61
6688 (SPI1) 0.39 0.54 0.50 0.46 0.44 0.46 0.50 0.50 0.47 1.00 0.78
6775 (STAT4) 0.48 0.61 0.62 0.58 0.55 0.54 0.60 0.50 0.61 0.78 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
LCP1 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
MEF2A 4205 LCP1 3936 distal 22955619 TRANSFAC
BATF 10538 LCP1 3936 distal 22955619 TRANSFAC
TCF12 6938 LCP1 3936 distal 22955619 TRANSFAC
SP1 6667 LCP1 3936 distal 22955619 TRANSFAC
EP300 2033 LCP1 3936 distal 22955619 TRANSFAC
IRF4 3662 LCP1 3936 distal 22955619 TRANSFAC
NFKB1 4790 LCP1 3936 distal 22955619 TRANSFAC
MEF2C 4208 LCP1 3936 distal 22955619 TRANSFAC
RXRA 6256 LCP1 3936 distal 22955619 TRANSFAC
SPI1 6688 LCP1 3936 distal 22955619 TRANSFAC
SRF 6722 LCP1 3936 distal 22955619 TRANSFAC
SMC3 9126 LCP1 3936 distal 22955619 TRANSFAC
BCL11A 53335 LCP1 3936 distal 22955619 TRANSFAC
PAX5 5079 LCP1 3936 distal 22955619 TRANSFAC
POU2F2 5452 LCP1 3936 distal 22955619 TRANSFAC
CHD2 1106 LCP1 3936 distal 22955619 TRANSFAC
EBF1 1879 LCP1 3936 distal 22955619 TRANSFAC
RAD21 5885 LCP1 3936 distal 22955619 TRANSFAC
STAT3 6774 LCP1 3936 distal 22955619 TRANSFAC
CTCF 10664 LCP1 3936 distal 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023871 hsa-miR-1-3p Homo sapiens LCP1 3936 Homo sapiens Proteomics;Microarray Functional MTI (Weak) 18668037
MIRT041160 hsa-miR-520a-3p Homo sapiens LCP1 3936 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT727317 hsa-miR-30c-5p Homo sapiens LCP1 3936 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT727318 hsa-miR-30d-5p Homo sapiens LCP1 3936 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT727316 hsa-miR-30e-5p Homo sapiens LCP1 3936 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT727319 hsa-miR-30b-5p Homo sapiens LCP1 3936 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT727320 hsa-miR-30a-5p Homo sapiens LCP1 3936 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
Gene Ontology
ID GO ID GO Term GO Type
3936 GO:0032587 ruffle membrane GOTERM_CC_DIRECT
3936 GO:0051764 actin crosslink formation GOTERM_BP_DIRECT
3936 GO:0003779 actin binding GOTERM_MF_DIRECT
3936 GO:0002102 podosome GOTERM_CC_DIRECT
3936 GO:0032432 actin filament bundle GOTERM_CC_DIRECT
3936 GO:0051639 actin filament network formation GOTERM_BP_DIRECT
3936 GO:0071803 positive regulation of podosome assembly GOTERM_BP_DIRECT
3936 GO:0005737 cytoplasm GOTERM_CC_DIRECT
3936 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3936 GO:0016477 cell migration GOTERM_BP_DIRECT
3936 GO:0051020 GTPase binding GOTERM_MF_DIRECT
3936 GO:0031100 organ regeneration GOTERM_BP_DIRECT
3936 GO:0033157 regulation of intracellular protein transport GOTERM_BP_DIRECT
3936 GO:0005925 focal adhesion GOTERM_CC_DIRECT
3936 GO:0042802 identical protein binding GOTERM_MF_DIRECT
3936 GO:0005509 calcium ion binding GOTERM_MF_DIRECT
3936 GO:0005829 cytosol GOTERM_CC_DIRECT
3936 GO:0030175 filopodium GOTERM_CC_DIRECT
3936 GO:0001725 stress fiber GOTERM_CC_DIRECT
3936 GO:0005884 actin filament GOTERM_CC_DIRECT
3936 GO:0005886 plasma membrane GOTERM_CC_DIRECT
3936 GO:0022617 extracellular matrix disassembly GOTERM_BP_DIRECT
3936 GO:0044319 wound healing GOTERM_BP_DIRECT
3936 GO:0051017 actin filament bundle assembly GOTERM_BP_DIRECT
3936 GO:0002286 T cell activation involved in immune response GOTERM_BP_DIRECT
3936 GO:0005615 extracellular space GOTERM_CC_DIRECT
3936 GO:0010737 protein kinase A signaling GOTERM_BP_DIRECT
3936 GO:0051015 actin filament binding GOTERM_MF_DIRECT
3936 GO:0001891 phagocytic cup GOTERM_CC_DIRECT
3936 GO:0001726 ruffle GOTERM_CC_DIRECT
3936 GO:0015629 actin cytoskeleton GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
LCP1 3936 Tobacco Dependence C0040332 Mental or Behavioral Dysfunction 0.3 0.672 0.414 disease
LCP1 3936 Nicotine Dependence C0028043 Mental or Behavioral Dysfunction 0.3 0.672 0.414 disease
LCP1 3936 Tobacco Use Disorder C0040336 Mental or Behavioral Dysfunction 0.3 0.672 0.414 disease
LCP1 3936 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.672 0.414 disease
LCP1 3936 Nicotine Use Disorder C0376384 Mental or Behavioral Dysfunction 0.3 0.672 0.414 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types