Serine/threonine-protein kinase pim-1

AltitudeomicsDB
Protein Official symbol PIM1
Aliases PIM1
Chromosomal Location  6
Length 313
Uniprot ID P11309
EC number 2.7.11.1
Protein family Information(Pfam) PF00069;
PDB id 1XQZ;1XR1;1XWS;1YHS;1YI3;1YI4;1YWV;1YXS;1YXT;1YXU;1YXV;1YXX;2BIK;2BIL;2BZH;2BZI;2BZJ;2BZK;2C3I;2J2I;2O3P;2O63;2O64;2O65;2OBJ;2OI4;2XIX;2XIY;2XIZ;2XJ0;2XJ1;2XJ2;3A99;3BGP;3BGQ;3BGZ;3BWF;3C4E;3CXW;3CY2;3CY3;3DCV;3F2A;3JPV;3JXW;3JY0;3JYA;3MA3;3QF9;3R00;3R01;3R02;3R04;3T9I;3UIX;3UMW;3UMX;3VBQ;3VBT;3VBV;3VBW;3VBX;3VBY;3VC4;3WE8;4A7C;4ALU;4ALV;4ALW;4AS0;4BZN;4BZO;4DTK;4ENX;4ENY;4GW8;4I41;4IAA;4JX3;4JX7;4K0Y;4K18;4K1B;4LL5;4LM5;4LMU;4MBI;4MBL;4MED;4MTA;4N6Y;4N6Z;4N70;4RBL;4RC2;4RC3;4RC4;4RPV;4TY1;4WRS;4WSY;4WT6;4XH6;4XHK;5C1Q;5DGZ;5DHJ;5DIA;5DWR;5EOL;5IIS;5IPJ;5KCX;5KGD;5KGE;5KGG;5KGI;5KGK;5KZI;5MZL;5N4N;5N4O;5N4R;5N4U;5N4V;5N4X;5N4Y;5N4Z;5N50;5N51;5N52;5N5L;5N5M;5NDT;5O11;5O12;5O13;5TEL;5TEX;5TOE;5TUR;5V80;5V82;5VUA;5VUB;5VUC;6AYD;6BSK;6KZI;6MT0;6NO8;6NO9;6PCW;6PDI;6PDN;6PDO;6PDP;6QXK;
InterPro ID IPR011009;IPR017348;IPR000719;IPR017441;IPR008271;
dbSNP rs35760989 rs200523275 rs33989191

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
MYC STAT3 0.985
MYC PIM1 0.973
MYC STAT6 0.95
NFATC1 PIM1 0.948
PIM1 STAT3 0.934
SND1 MYB 0.931
STAT6 STAT3 0.931
MYC MAX 0.928
PIM1 MYB 0.927
PIM1 STAT6 0.924
HRAS SND1 0.921
HRAS PIM1 0.918
SND1 KRAS 0.915
PIM1 KRAS 0.914
PIM1 NRAS 0.905
NRAS KRAS 0.904
MYC HRAS 0.903
PIM1 MAX 0.903
HRAS KRAS 0.902
HRAS NRAS 0.902
PIM1 SND1 0.9
NRAS SND1 0.9
Gene Ontology Semantic Similarity
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# 4609 (MYC) 4772 (NFATC1) 5292 (PIM1) 27044 (SND1) 6778 (STAT6) 3265 (HRAS) 4893 (NRAS) 6774 (STAT3) 4602 (MYB) 4149 (MAX) 3845 (KRAS)
4609 (MYC) 1.00 0.83 0.52 0.46 0.81 0.46 0.56 0.87 0.84 0.82 0.56
4772 (NFATC1) 0.83 1.00 0.48 0.42 0.80 0.43 0.51 0.80 0.78 0.72 0.51
5292 (PIM1) 0.52 0.48 1.00 0.41 0.47 0.63 0.60 0.49 0.43 0.37 0.60
27044 (SND1) 0.46 0.42 0.41 1.00 0.41 0.44 0.43 0.48 0.37 0.50 0.43
6778 (STAT6) 0.81 0.80 0.47 0.41 1.00 0.46 0.54 0.84 0.87 0.78 0.54
3265 (HRAS) 0.46 0.43 0.63 0.44 0.46 1.00 0.55 0.47 0.42 0.37 0.55
4893 (NRAS) 0.56 0.51 0.60 0.43 0.54 0.55 1.00 0.51 0.52 0.38 1.00
6774 (STAT3) 0.87 0.80 0.49 0.48 0.84 0.47 0.51 1.00 0.78 0.80 0.51
4602 (MYB) 0.84 0.78 0.43 0.37 0.87 0.42 0.52 0.78 1.00 0.71 0.52
4149 (MAX) 0.82 0.72 0.37 0.50 0.78 0.37 0.38 0.80 0.71 1.00 0.38
3845 (KRAS) 0.56 0.51 0.60 0.43 0.54 0.55 1.00 0.51 0.52 0.38 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PIM1 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 2.2 RT-qPCR Western US C57BL/6 mice 1.2 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
PIM1 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 5.8 RT-qPCR Western US C57BL/6 mice 1.2 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
MYC 4609 PIM1 5292 distal 22955619 TRANSFAC
TCF4 6925 PIM1 5292 distal 22955619 TRANSFAC
HNF4A 3172 PIM1 5292 distal 22955619 TRANSFAC
E2F6 1876 PIM1 5292 distal 22955619 TRANSFAC
HNF4G 3174 PIM1 5292 distal 22955619 TRANSFAC
FOXA2 3170 PIM1 5292 distal 22955619 TRANSFAC
RXRA 6256 PIM1 5292 distal 22955619 TRANSFAC
USF1 7391 PIM1 5292 distal 22955619 TRANSFAC
EP300 2033 PIM1 5292 distal 22955619 TRANSFAC
BHLHE40 8553 PIM1 5292 distal 22955619 TRANSFAC
HDAC2 3066 PIM1 5292 distal 22955619 TRANSFAC
FOXA1 3169 PIM1 5292 distal 22955619 TRANSFAC
JUND 3727 PIM1 5292 distal 22955619 TRANSFAC
CTBP2 1488 PIM1 5292 distal 22955619 TRANSFAC
SP1 6667 PIM1 5292 distal 22955619 TRANSFAC
MAFK 7975 PIM1 5292 distal 22955619 TRANSFAC
CEBPB 1051 PIM1 5292 distal 22955619 TRANSFAC
CCNT2 905 PIM1 5292 proximal_filtered 22955619 TRANSFAC
RAD21 5885 PIM1 5292 proximal_filtered 22955619 TRANSFAC
E2F4 1874 PIM1 5292 proximal_filtered 22955619 TRANSFAC
STAT3 6774 PIM1 5292 Repression 7559553 TRUSST
ABL1 25 PIM1 5292 Repression 24403858 TRUSST
STAT1 6772 PIM1 5292 Unknown 8137237 TRUSST
ERG 2078 PIM1 5292 Unknown 9694711 TRUSST
STAT4 6775 PIM1 5292 Activation 7848925 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT000151 hsa-miR-210-3p Homo sapiens PIM1 5292 Homo sapiens Luciferase reporter assay Functional MTI 19782034
MIRT004322 hsa-miR-1-3p Homo sapiens PIM1 5292 Homo sapiens qRT-PCR//Luciferase reporter assay//Western blot Functional MTI 18818206
MIRT004322 hsa-miR-1-3p Homo sapiens PIM1 5292 Homo sapiens Luciferase reporter assay//Northern blot//Western blot Functional MTI 21051663
MIRT004322 hsa-miR-1-3p Homo sapiens PIM1 5292 Homo sapiens Western blot Functional MTI 26820394
MIRT004857 hsa-miR-192-5p Homo sapiens PIM1 5292 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT004857 hsa-miR-192-5p Homo sapiens PIM1 5292 Homo sapiens Luciferase reporter assay//qRT-PCR//Reporter assay;Microarray;Other Functional MTI 19074876
MIRT006870 hsa-miR-16-5p Homo sapiens PIM1 5292 Homo sapiens Luciferase reporter assay Functional MTI 22970245
MIRT006870 hsa-miR-16-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT017680 hsa-miR-335-5p Homo sapiens PIM1 5292 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT024423 hsa-miR-215-5p Homo sapiens PIM1 5292 Homo sapiens Microarray Functional MTI (Weak) 19074876
MIRT028248 hsa-miR-33a-5p Homo sapiens PIM1 5292 Homo sapiens Reporter assay Functional MTI 21743487
MIRT054035 hsa-miR-33b-5p Homo sapiens PIM1 5292 Homo sapiens Flow//Luciferase reporter assay//Microarray//qRT-PCR//Western blot Functional MTI 22983447
MIRT100569 hsa-miR-214-3p Homo sapiens PIM1 5292 Homo sapiens Western blot Functional MTI 26820394
MIRT100579 hsa-miR-4531 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100585 hsa-miR-6838-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100576 hsa-miR-3619-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100577 hsa-miR-4434 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100573 hsa-miR-497-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100570 hsa-miR-15b-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100572 hsa-miR-424-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100578 hsa-miR-4516 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100571 hsa-miR-195-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100575 hsa-miR-761 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100574 hsa-miR-583 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100566 hsa-miR-15a-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100581 hsa-miR-5703 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100569 hsa-miR-214-3p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100569 hsa-miR-214-3p Homo sapiens PIM1 5292 Homo sapiens Microarray//qRT-PCR Functional MTI (Weak) 22815788
MIRT168868 hsa-miR-124-3p Homo sapiens PIM1 5292 Homo sapiens Luciferase reporter assay Functional MTI 27088547
MIRT168877 hsa-miR-542-3p Homo sapiens PIM1 5292 Homo sapiens Luciferase reporter assay Functional MTI 27107696
MIRT168865 hsa-miR-26a-5p Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT168866 hsa-miR-26b-5p Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT218892 hsa-miR-101-3p Homo sapiens PIM1 5292 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 26693056
MIRT218896 hsa-miR-486-5p Homo sapiens PIM1 5292 Homo sapiens qRT-PCR Functional MTI (Weak) 23294929
MIRT513756 hsa-miR-1246 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT513757 hsa-miR-7850-5p Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT513758 hsa-miR-620 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT513759 hsa-miR-1270 Homo sapiens PIM1 5292 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT700781 hsa-miR-4736 Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700779 hsa-miR-7150 Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700786 hsa-miR-584-3p Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700782 hsa-miR-4763-3p Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700783 hsa-miR-1207-5p Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700785 hsa-miR-1252-5p Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700788 hsa-miR-4496 Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700789 hsa-miR-651-3p Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700780 hsa-miR-5581-3p Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700787 hsa-miR-1272 Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT700784 hsa-miR-4261 Homo sapiens PIM1 5292 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
Gene Ontology
ID GO ID GO Term GO Type
5292 GO:0008283 cell proliferation GOTERM_BP_DIRECT
5292 GO:0030212 hyaluronan metabolic process GOTERM_BP_DIRECT
5292 GO:0005524 ATP binding GOTERM_MF_DIRECT
5292 GO:0046777 protein autophosphorylation GOTERM_BP_DIRECT
5292 GO:0006915 apoptotic process GOTERM_BP_DIRECT
5292 GO:0007275 multicellular organism development GOTERM_BP_DIRECT
5292 GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GOTERM_BP_DIRECT
5292 GO:0004674 protein serine/threonine kinase activity GOTERM_MF_DIRECT
5292 GO:0070561 vitamin D receptor signaling pathway GOTERM_BP_DIRECT
5292 GO:0008134 transcription factor binding GOTERM_MF_DIRECT
5292 GO:0005886 plasma membrane GOTERM_CC_DIRECT
5292 GO:0006468 protein phosphorylation GOTERM_BP_DIRECT
5292 GO:0005515 protein binding GOTERM_MF_DIRECT
5292 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
5292 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GOTERM_BP_DIRECT
5292 GO:0043024 ribosome binding GOTERM_MF_DIRECT
5292 GO:0005737 cytoplasm GOTERM_CC_DIRECT
5292 GO:0007049 cell cycle GOTERM_BP_DIRECT
5292 GO:0005634 nucleus GOTERM_CC_DIRECT
5292 GO:0030145 MHC class II protein complex binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5292 hsa04630 Jak-STAT signaling pathway
5292 hsa05221 Acute myeloid leukemia
5292 hsa05206 MicroRNAs in cancer
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PIM1 5292 Neoplastic Cell Transformation C0007621 Neoplastic Process 0.3 0.532 0.621 phenotype
PIM1 5292 Condition, Preneoplastic C0282313 Neoplastic Process 0.3 0.532 0.621 phenotype
PIM1 5292 Congenital hernia of foramen of Bochdalek C0265700 Congenital Abnormality 0.3 0.532 0.621 disease
PIM1 5292 Breast Carcinoma C0678222 Neoplastic Process 0.32 0.532 0.621 disease
PIM1 5292 Mammary Neoplasms C1458155 Neoplastic Process 0.31 0.532 0.621 group
PIM1 5292 Congenital hernia of foramen of Morgagni C0265699 Congenital Abnormality 0.3 0.532 0.621 disease
PIM1 5292 Prostatic Intraepithelial Neoplasias C0282612 Neoplastic Process 0.32 0.532 0.621 disease
PIM1 5292 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.532 0.621 group
PIM1 5292 Pyelonephritis acute necrotizing C1704315 Disease or Syndrome 0.3 0.532 0.621 disease
PIM1 5292 Congenital diaphragmatic hernia C0235833 Disease or Syndrome 0.3 0.532 0.621 disease
PIM1 5292 Giant Cell Glioblastoma C0334588 Neoplastic Process 0.3 0.532 0.621 disease
PIM1 5292 Precancerous Conditions C0032927 Neoplastic Process 0.3 0.532 0.621 group
PIM1 5292 Malignant neoplasm of breast C0006142 Neoplastic Process 0.32 0.532 0.621 disease
PIM1 5292 Glioblastoma C0017636 Neoplastic Process 0.31 0.532 0.621 disease
PIM1 5292 Pyelonephritis C0034186 Disease or Syndrome 0.31 0.532 0.621 disease
PIM1 5292 Dermatitis, Allergic Contact C0162820 Disease or Syndrome 0.3 0.532 0.621 disease
PIM1 5292 Glioblastoma Multiforme C1621958 Neoplastic Process 0.3 0.532 0.621 disease
PIM1 5292 Adenocarcinoma of large intestine C1319315 Neoplastic Process 0.3 0.532 0.621 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
PIM1 5292 AKT INHIBITOR X ISONICOTINIC ACID CHEMBL1203 inhibitor
PIM1 5292 AZD-1208 AZD-1208 CHEMBL3545423 inhibitor
PIM1 5292 AZD1208 AZD-1208 CHEMBL3545423 inhibitor
PIM1 5292 COMPOUND 14K [PMID: 21982499] None None inhibitor
PIM1 5292 COMPOUND 2 [PMID: 22560567] None None inhibitor
PIM1 5292 COMPOUND 20 [PMID: 22136433] None None inhibitor
PIM1 5292 CX-5011 None None inhibitor
PIM1 5292 CX-4945 SILMITASERTIB CHEMBL1230165 inhibitor
PIM1 5292 CX-6258 None None inhibitor
PIM1 5292 CX-5279 None None inhibitor
PIM1 5292 LEUCETTINE L41 None None inhibitor
PIM1 5292 LGB321 None None inhibitor
PIM1 5292 LGH-447 LGH-447 CHEMBL3545194 inhibitor
PIM1 5292 RAPAMYCIN SIROLIMUS CHEMBL413 None
PIM1 5292 RUBOXISTAURIN RUBOXISTAURIN CHEMBL91829 inhibitor
PIM1 5292 SGI-1776 SGI-1776 CHEMBL1952329 inhibitor
PIM1 5292 SGI-1776 SGI-1776 CHEMBL1952329 inhibitor
PIM1 5292 SGI-1776 SGI-1776 CHEMBL1952329 None
PIM1 5292 XL413 CHEMBL2030402 CHEMBL2030402 inhibitor