Prolactin-inducible protein
AltitudeomicsDB
| Protein Official symbol |
PIP |
| Aliases |
PIP GCDFP15 GPIP4 |
| Chromosomal Location |
7 |
| Length |
146 |
| Uniprot ID |
P12273 |
| EC number |
None |
| Protein family Information(Pfam) |
PF05326; |
| PDB id |
3ES6; |
| InterPro ID |
IPR013783;IPR014756;IPR007990; |
| dbSNP |
None |
AltitudeomicsDB
| Protein 1 |
Protein 2 |
Combine Score |
| AZGP1 |
PIP |
0.991 |
| KRT7 |
PIP |
0.836 |
| KRT7 |
CEACAM5 |
0.836 |
| PIP |
SCGB2A2 |
0.787 |
| KEL |
PIP |
0.757 |
| PIP |
BPIFA2 |
0.742 |
| PIP |
CEACAM5 |
0.705 |
| PGR |
PIP |
0.7020000000000001 |
Gene Ontology Semantic Similarity
Download Tab separated file
| # |
563 (AZGP1) |
3855 (KRT7) |
5304 (PIP) |
3792 (KEL) |
5241 (PGR) |
1048 (CEACAM5) |
4250 (SCGB2A2) |
140683 (BPIFA2) |
|
563 (AZGP1)
|
1.00
|
1.00
|
0.67
|
0.57
|
0.52
|
0.49
|
0.61
|
0.59
|
|
3855 (KRT7)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.82
|
1.00
|
1.00
|
|
5304 (PIP)
|
0.67
|
1.00
|
1.00
|
0.75
|
0.59
|
0.57
|
0.68
|
0.68
|
|
3792 (KEL)
|
0.57
|
1.00
|
0.75
|
1.00
|
0.54
|
0.52
|
0.67
|
0.64
|
|
5241 (PGR)
|
0.52
|
1.00
|
0.59
|
0.54
|
1.00
|
0.47
|
0.59
|
0.57
|
|
1048 (CEACAM5)
|
0.49
|
0.82
|
0.57
|
0.52
|
0.47
|
1.00
|
0.58
|
0.64
|
|
4250 (SCGB2A2)
|
0.61
|
1.00
|
0.68
|
0.67
|
0.59
|
0.58
|
1.00
|
0.72
|
|
140683 (BPIFA2)
|
0.59
|
1.00
|
0.68
|
0.64
|
0.57
|
0.64
|
0.72
|
1.00
|
Association with High Altitude
| Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
| PIP |
Human |
Saliva |
- |
4175 m |
7 day |
downregulated |
1.56 |
2-DE |
Himalayas |
Indians |
5.95 |
Individuals residing at sea level |
30219637 |
Association with miRNA
| miRTarBase ID |
miRNA |
Species (miRNA) |
Protein Official Symbol |
Human Entrez ID |
Species (Target Gene) |
Experiments |
Support Type |
References (PMID) |
Gene Ontology
| ID |
GO ID |
GO Term |
GO Type |
| 5304 |
GO:0001580 |
detection of chemical stimulus involved in sensory perception of bitter taste |
GOTERM_BP_DIRECT |
| 5304 |
GO:0001948 |
glycoprotein binding |
GOTERM_MF_DIRECT |
| 5304 |
GO:0016324 |
apical plasma membrane |
GOTERM_CC_DIRECT |
| 5304 |
GO:0003779 |
actin binding |
GOTERM_MF_DIRECT |
| 5304 |
GO:0004190 |
serine-type carboxypeptidase activity |
GOTERM_MF_DIRECT |
| 5304 |
GO:0002682 |
regulation of immune system process |
GOTERM_BP_DIRECT |
| 5304 |
GO:0046983 |
protein dimerization activity |
GOTERM_MF_DIRECT |
| 5304 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
| 5304 |
GO:0019864 |
calcium channel inhibitor activity |
GOTERM_MF_DIRECT |
| 5304 |
GO:0005615 |
extracellular space |
GOTERM_CC_DIRECT |
| 5304 |
GO:0070233 |
negative regulation of T cell apoptotic process |
GOTERM_BP_DIRECT |
| 5304 |
GO:0005576 |
extracellular region |
GOTERM_CC_DIRECT |
| 5304 |
GO:0010628 |
positive regulation of gene expression |
GOTERM_BP_DIRECT |
| 5304 |
GO:0070062 |
extracellular exosome |
GOTERM_CC_DIRECT |
| 5304 |
GO:0055085 |
transmembrane transport |
GOTERM_BP_DIRECT |
| 5304 |
GO:0001895 |
retina homeostasis |
GOTERM_BP_DIRECT |
| 5304 |
GO:0005634 |
nucleus |
GOTERM_CC_DIRECT |
| 5304 |
GO:0006508 |
proteolysis |
GOTERM_BP_DIRECT |
Pathways
| Human Entrez ID |
KEGG ID |
KEGG Term |
Association with Disease
| Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
| PIP |
5304 |
Sinusitis |
C0037199 |
Disease or Syndrome |
0.3 |
0.645 |
0.655 |
disease |
Association with Drug
| Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |
| PIP |
5304 |
HORMONES |
None |
None |
None |
| PIP |
5304 |
TAMOXIFEN |
TAMOXIFEN |
CHEMBL83 |
None |