ALTITUDEOMICSDB

Peptidyl-prolyl cis-trans isomerase A

AltitudeomicsDB

Protein Official symbol	PPIA
Aliases	PPIA CYPA
Chromosomal Location	7
Length	165
Uniprot ID	P62937
EC number	5.2.1.8
Protein family Information(Pfam)	PF00160;
PDB id	1AK4;1AWQ;1AWR;1AWS;1AWT;1AWU;1AWV;1BCK;1CWA;1CWB;1CWC;1CWF;1CWH;1CWI;1CWJ;1CWK;1CWL;1CWM;1CWO;1FGL;1M63;1M9C;1M9D;1M9E;1M9F;1M9X;1M9Y;1MF8;1MIK;1NMK;1OCA;1RMH;1VBS;1VBT;1W8L;1W8M;1W8V;1YND;1ZKF;2ALF;2CPL;2CYH;2MS4;2MZU;2N0T;2RMA;2RMB;2X25;2X2A;2X2C;2X2D;2XGY;3CYH;3CYS;3K0M;3K0N;3K0O;3K0P;3K0Q;3K0R;3ODI;3ODL;3RDD;4CYH;4IPZ;4N1M;4N1N;4N1O;4N1P;4N1Q;4N1R;4N1S;4YUG;4YUH;4YUI;4YUJ;4YUK;4YUL;4YUM;4YUN;4YUO;4YUP;5CYH;5F66;5FJB;5KUL;5KUN;5KUO;5KUQ;5KUR;5KUS;5KUU;5KUV;5KUW;5KUZ;5KV0;5KV1;5KV2;5KV3;5KV4;5KV5;5KV6;5KV7;5LUD;5NOQ;5NOR;5NOS;5NOT;5NOU;5NOV;5NOW;5NOX;5NOY;5NOZ;5T9U;5T9W;5T9Z;5TA2;5TA4;5WC7;6BTA;6GJI;6GJJ;6GJL;6GJM;6GJN;6GJP;6GJR;6GJY;6GS6;6I42;6U5C;6U5D;6U5E;6U5G;
InterPro ID	IPR029000;IPR024936;IPR020892;IPR002130;
dbSNP	None

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
PPP3CA	PPP3R1	0.996
PPP3CB	PPP3R1	0.985
NFATC3	PPP3R1	0.973
PPIA	BSG	0.967
NFATC2	PPP3R1	0.957
NFATC1	PPP3R1	0.955
NFATC1	PPP3CA	0.952
PPP3CA	NFATC3	0.948
NFATC1	MAPK3	0.946
PPP3CB	NFATC3	0.943
NFATC2	PPP3CA	0.942
NFATC1	PPP3CB	0.941
BSG	MAPK3	0.938
NFATC2	PPP3CB	0.938
PPIA	PPP3R1	0.934
PPIA	MAPK3	0.933
PPIA	PPP3CA	0.932
PPIA	MAPK1	0.926
PPIA	PPP3CB	0.923
BSG	MAPK1	0.922
PPIA	NFATC1	0.919
NFATC2	NFATC3	0.919
NFATC1	NFATC2	0.918
PPIA	NFATC2	0.915
NFATC1	NFATC3	0.914
PPIA	NFATC3	0.905
PPP3CA	PPP3CB	0.904
PPIA	STAT4	0.902
MAPK3	MAPK1	0.902

Gene Ontology Semantic Similarity

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#	5530 (PPP3CA)	4772 (NFATC1)	5478 (PPIA)	5532 (PPP3CB)	5595 (MAPK3)	4775 (NFATC3)	4773 (NFATC2)	682 (BSG)	1072 (CFL1)	5534 (PPP3R1)	5594 (MAPK1)	9131 (AIFM1)	6775 (STAT4)
5530 (PPP3CA)	1.00	0.51	0.65	0.96	0.53	0.50	0.55	0.57	0.59	0.92	0.52	0.55	1.00
4772 (NFATC1)	0.51	1.00	0.51	0.52	0.41	0.69	0.71	0.46	0.48	0.49	0.42	0.42	1.00
5478 (PPIA)	0.65	0.51	1.00	0.60	0.52	0.50	0.64	0.57	0.61	0.68	0.52	0.56	1.00
5532 (PPP3CB)	0.96	0.52	0.60	1.00	0.56	0.51	0.57	0.58	0.61	0.86	0.55	0.56	1.00
5595 (MAPK3)	0.53	0.41	0.52	0.56	1.00	0.40	0.47	0.49	0.52	0.51	0.98	0.50	1.00
4775 (NFATC3)	0.50	0.69	0.50	0.51	0.40	1.00	0.68	0.47	0.50	0.50	0.41	0.41	1.00
4773 (NFATC2)	0.55	0.71	0.64	0.57	0.47	0.68	1.00	0.57	0.63	0.57	0.47	0.50	1.00
682 (BSG)	0.57	0.46	0.57	0.58	0.49	0.47	0.57	1.00	0.66	0.59	0.49	0.53	1.00
1072 (CFL1)	0.59	0.48	0.61	0.61	0.52	0.50	0.63	0.66	1.00	0.62	0.51	0.58	1.00
5534 (PPP3R1)	0.92	0.49	0.68	0.86	0.51	0.50	0.57	0.59	0.62	1.00	0.51	0.55	1.00
5594 (MAPK1)	0.52	0.42	0.52	0.55	0.98	0.41	0.47	0.49	0.51	0.51	1.00	0.50	1.00
9131 (AIFM1)	0.55	0.42	0.56	0.56	0.50	0.41	0.50	0.53	0.58	0.55	0.50	1.00	1.00
6775 (STAT4)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
PPIA	Human	Blood	-	3600 m	Native	upregulated	-	TMT-based proteomic analysis/LC-MS	Central Asia	Tibetans	-	High altitude native vs. low Lander	30908922
PPIA	Rat	Kidney	-	7628 m	7 day	downregulated	-2.28	2-DE	Northern indo-australian plate	Male sprague-dawley	1	Male SD rats weighing 250-260g	30005088

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
MYC	4609	PPIA	5478	proximal_filtered	22955619	TRANSFAC
TAF1	6872	PPIA	5478	proximal_filtered	22955619	TRANSFAC
PBX3	5090	PPIA	5478	proximal_filtered	22955619	TRANSFAC
E2F6	1876	PPIA	5478	proximal_filtered	22955619	TRANSFAC
MAX	4149	PPIA	5478	proximal_filtered	22955619	TRANSFAC
SREBF1	6720	PPIA	5478	proximal_filtered	22955619	TRANSFAC
FOS	2353	PPIA	5478	proximal_filtered	22955619	TRANSFAC
NFYB	4801	PPIA	5478	proximal_filtered	22955619	TRANSFAC
ESRRA	2101	PPIA	5478	proximal_filtered	22955619	TRANSFAC

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT023905	hsa-miR-1-3p	Homo sapiens	PPIA	5478	Homo sapiens	Proteomics	Functional MTI (Weak)	18668040
MIRT035823	hsa-miR-1307-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT036191	hsa-miR-320b	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT036511	hsa-miR-1226-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT036733	hsa-miR-760	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT038227	hsa-miR-342-5p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT038540	hsa-miR-30c-1-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT037899	hsa-miR-455-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT038227	hsa-miR-342-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT038051	hsa-miR-423-5p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT038938	hsa-miR-31-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT040751	hsa-miR-18a-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT043038	hsa-miR-324-5p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT044321	hsa-miR-106b-5p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT044403	hsa-miR-320a	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT046998	hsa-miR-218-5p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT048054	hsa-miR-197-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT050185	hsa-miR-26a-5p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT050789	hsa-miR-17-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT050690	hsa-miR-18a-5p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT052825	hsa-miR-3200-3p	Homo sapiens	PPIA	5478	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT452658	hsa-miR-548v	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452658	hsa-miR-548v	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452661	hsa-miR-7978	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452655	hsa-miR-1200	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452657	hsa-miR-323a-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452668	hsa-miR-544b	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452667	hsa-miR-3653-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452668	hsa-miR-544b	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452663	hsa-miR-548q	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452664	hsa-miR-4299	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452664	hsa-miR-4299	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452665	hsa-miR-6845-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452655	hsa-miR-1200	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452656	hsa-miR-876-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452657	hsa-miR-323a-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452659	hsa-miR-610	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452658	hsa-miR-548v	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452659	hsa-miR-610	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452660	hsa-miR-1252-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452656	hsa-miR-876-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452660	hsa-miR-1252-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452666	hsa-miR-1976	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452669	hsa-miR-4324	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452665	hsa-miR-6845-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452665	hsa-miR-6845-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452669	hsa-miR-4324	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452669	hsa-miR-4324	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452662	hsa-miR-4456	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452660	hsa-miR-1252-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452655	hsa-miR-1200	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452656	hsa-miR-876-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452657	hsa-miR-323a-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452670	hsa-miR-4662a-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452663	hsa-miR-548q	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452666	hsa-miR-1976	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452670	hsa-miR-4662a-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452667	hsa-miR-3653-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452662	hsa-miR-4456	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452664	hsa-miR-4299	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452661	hsa-miR-7978	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452661	hsa-miR-7978	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452659	hsa-miR-610	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452667	hsa-miR-3653-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452662	hsa-miR-4456	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452666	hsa-miR-1976	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT452670	hsa-miR-4662a-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT452663	hsa-miR-548q	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT452668	hsa-miR-544b	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	26701625
MIRT526481	hsa-miR-4668-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT526482	hsa-miR-3148	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT526487	hsa-miR-548d-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT526487	hsa-miR-548d-3p	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526483	hsa-miR-548ay-3p	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526484	hsa-miR-548at-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT526486	hsa-miR-548h-3p	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526483	hsa-miR-548ay-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT526482	hsa-miR-3148	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526488	hsa-miR-548bb-3p	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526489	hsa-miR-548ac	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT526481	hsa-miR-4668-5p	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526485	hsa-miR-548z	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526484	hsa-miR-548at-3p	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526485	hsa-miR-548z	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT526489	hsa-miR-548ac	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT526486	hsa-miR-548h-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT526488	hsa-miR-548bb-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22012620
MIRT615272	hsa-miR-6783-5p	Homo sapiens	PPIA	5478	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23824327
MIRT761201	hsa-miR-1184	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT761606	hsa-miR-1249-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT763196	hsa-miR-186-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT763398	hsa-miR-1914-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT766230	hsa-miR-363-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT767580	hsa-miR-3907	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT768736	hsa-miR-4418	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT769473	hsa-miR-4471	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT770735	hsa-miR-4651	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT770815	hsa-miR-4664-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT772555	hsa-miR-4802-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT773624	hsa-miR-5194	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT773264	hsa-miR-509-3-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT773302	hsa-miR-509-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT775236	hsa-miR-570-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT775425	hsa-miR-6068	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT775761	hsa-miR-608	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT777041	hsa-miR-6515-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT777025	hsa-miR-651-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT778317	hsa-miR-6747-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT778095	hsa-miR-6737-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT778103	hsa-miR-6738-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT778198	hsa-miR-6745	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT778342	hsa-miR-6750-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT779062	hsa-miR-6782-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT779371	hsa-miR-6797-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT779775	hsa-miR-6812-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT779854	hsa-miR-6819-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT779867	hsa-miR-6822-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT780002	hsa-miR-6830-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT780846	hsa-miR-6880-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT781157	hsa-miR-6890-5p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT782162	hsa-miR-7847-3p	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT782333	hsa-miR-8059	Homo sapiens	PPIA	5478	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025

Gene Ontology

ID	GO ID	GO Term	GO Type
5478	GO:0005925	focal adhesion	GOTERM_CC_DIRECT
5478	GO:0019068	virion assembly	GOTERM_BP_DIRECT
5478	GO:0019064	fusion of virus membrane with host plasma membrane	GOTERM_BP_DIRECT
5478	GO:0045069	regulation of viral genome replication	GOTERM_BP_DIRECT
5478	GO:0005576	extracellular region	GOTERM_CC_DIRECT
5478	GO:0006278	RNA-dependent DNA biosynthetic process	GOTERM_BP_DIRECT
5478	GO:0006457	protein folding	GOTERM_BP_DIRECT
5478	GO:0050714	positive regulation of protein secretion	GOTERM_BP_DIRECT
5478	GO:0042277	peptide binding	GOTERM_MF_DIRECT
5478	GO:0030260	entry into host cell	GOTERM_BP_DIRECT
5478	GO:0016020	membrane	GOTERM_CC_DIRECT
5478	GO:0050900	leukocyte migration	GOTERM_BP_DIRECT
5478	GO:0019061	uncoating of virus	GOTERM_BP_DIRECT
5478	GO:0044822	poly	GOTERM_MF_DIRECT
5478	GO:0075713	establishment of integrated proviral latency	GOTERM_BP_DIRECT
5478	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
5478	GO:0045070	positive regulation of viral genome replication	GOTERM_BP_DIRECT
5478	GO:0051082	unfolded protein binding	GOTERM_MF_DIRECT
5478	GO:0005615	extracellular space	GOTERM_CC_DIRECT
5478	GO:0019076	viral release from host cell	GOTERM_BP_DIRECT
5478	GO:0019058	viral life cycle	GOTERM_BP_DIRECT
5478	GO:0005515	protein binding	GOTERM_MF_DIRECT
5478	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GOTERM_MF_DIRECT
5478	GO:0046790	2	GOTERM_MF_DIRECT
5478	GO:0034389	lipid particle organization	GOTERM_BP_DIRECT
5478	GO:0005634	nucleus	GOTERM_CC_DIRECT
5478	GO:0005829	cytosol	GOTERM_CC_DIRECT
5478	GO:0000413	protein peptidyl-prolyl isomerization	GOTERM_BP_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
PPIA	5478	Malignant neoplasm of mouth	C0153381	Neoplastic Process	0.3	0.57	0.724	disease
PPIA	5478	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.57	0.724	disease
PPIA	5478	Neoplasm Metastasis	C0027627	Neoplastic Process	0.34	0.57	0.724	phenotype
PPIA	5478	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.31	0.57	0.724	disease
PPIA	5478	Mouth Neoplasms	C0026640	Neoplastic Process	0.3	0.57	0.724	group
PPIA	5478	Squamous cell carcinoma	C0007137	Neoplastic Process	0.3	0.57	0.724	disease
PPIA	5478	Non-Small Cell Lung Carcinoma	C0007131	Neoplastic Process	0.34	0.57	0.724	disease
PPIA	5478	Stomach Neoplasms	C0038356	Neoplastic Process	0.3	0.57	0.724	group
PPIA	5478	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.31	0.57	0.724	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
PPIA	5478	CSA	CYCLOSPORINE	CHEMBL160	None
PPIA	5478	CYCLOSPORIN A	CYCLOSPORINE	CHEMBL160	inhibitor
PPIA	5478	CYCLOSPORINE	CYCLOSPORINE	CHEMBL160	modulator
PPIA	5478	IMMUNOSUPPRESSIVE	None	None	None
PPIA	5478	L-PROLINE	L-PROLINE	CHEMBL54922	binder
PPIA	5478	SCY-635	CHEMBL1269597	CHEMBL1269597	None
PPIA	5478	VOCLOSPORIN	VOCLOSPORIN	CHEMBL2218919	None