ALTITUDEOMICSDB

Retinoic acid receptor, alpha

AltitudeomicsDB

Protein Official symbol	RARA
Aliases	RARA NR1B1
Chromosomal Location	17
Length	462
Uniprot ID	P10276
EC number	None
Protein family Information(Pfam)	PF00104;PF00105;
PDB id	1DKF;1DSZ;3A9E;3KMR;3KMZ;4DQM;5K13;
InterPro ID	IPR035500;IPR000536;IPR001723;IPR003078;IPR001628;IPR013088;
dbSNP	None

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
CCNH	CDK7	0.999
NCOR2	HDAC3	0.999
MNAT1	CDK7	0.999
NCOA1	CREBBP	0.999
SUMO2	UBE2I	0.999
MNAT1	CCNH	0.999
NCOA3	CREBBP	0.999
EZH2	SUZ12	0.999
NCOA2	NR3C1	0.998
RXRA	RARA	0.998
RXRB	RARA	0.998
NCOR1	RARA	0.998
NCOA1	RARB	0.997
RXRA	NCOA2	0.997
RXRA	NCOA1	0.997
RXRA	NCOR2	0.997
KDM6A	KMT2D	0.996
RARG	RXRB	0.996
HDAC1	EZH2	0.996
NCOA1	EP300	0.995
RXRA	THRB	0.995
HDAC3	NCOR1	0.995
NCOA3	EP300	0.995
PBX1	HOXB1	0.994
KMT2D	EP300	0.994
NCOR2	HDAC1	0.994
HDAC1	NCOR1	0.993
EZH2	YY1	0.993
KAT2B	EP300	0.993
HDAC1	SUZ12	0.993
RARB	RARA	0.992
HDAC1	EP300	0.991
RXRA	CREBBP	0.991
HDAC1	YY1	0.99
NCOA1	RARA	0.99
EP300	CREBBP	0.99
NCOA3	CARM1	0.99
KAT2B	CREBBP	0.989
NCOR2	RARA	0.989
RXRA	MED1	0.989
RXRA	NCOR1	0.989
NCOA1	NR3C1	0.988
HDAC1	CREBBP	0.988
HIST2H2BE	KAT2B	0.988
HDAC3	KAT2B	0.987
MAPK3	MAPK1	0.987
RXRA	RARB	0.987
NCOA2	CREBBP	0.987
RXRA	RARG	0.987
RARG	NCOA1	0.986
NCOR1	EP300	0.986
NCOA2	EP300	0.986
RARG	NCOR1	0.986
RARG	NCOR2	0.986
NCOR1	NR3C1	0.986
CARM1	EP300	0.985
PBX1	MEIS1	0.985
NCOA3	KAT2B	0.985
SUZ12	CTCF	0.985
NCOR2	RARB	0.985
RARG	RARA	0.985
KDM6A	EZH2	0.985
RXRG	RARA	0.985
HDAC1	KAT2B	0.984
NCOA2	CARM1	0.984
CARM1	CREBBP	0.984
RARB	NCOR1	0.982
RXRB	RARB	0.982
RARG	RXRG	0.982
KMT2D	NCOR1	0.981
NCOR2	RXRG	0.981
NCOR2	CREBBP	0.981
NCOA6	KMT2D	0.981
NCOA1	NCOR1	0.98
RXRB	NCOR1	0.98
NCOA3	NCOR1	0.98
RXRA	NRIP1	0.98
NCOR2	NCOA3	0.98
EP300	NR3C1	0.979
NCOR2	RXRB	0.979
HDAC3	EP300	0.979
KDM6A	NCOA6	0.979
CREBBP	NR3C1	0.978
NCOR1	CREBBP	0.978
KMT2D	CREBBP	0.978
NCOA6	EP300	0.977
NCOR2	EP300	0.977
NCOA1	KAT2B	0.977
RXRG	RARB	0.977
NCOA1	CARM1	0.976
HDAC3	CREBBP	0.976
AKT1	EP300	0.976
EP300	YY1	0.975
NRIP1	NCOR1	0.975
RXRA	EP300	0.975
SUZ12	YY1	0.975
HIST2H2BE	EP300	0.975
EZH2	EP300	0.974
CARM1	KAT2B	0.973
NCOA3	NR3C1	0.973
SUMO2	PML	0.973
RARB	MED1	0.972
HIST2H2BE	CREBBP	0.972
AKT1	NCOR2	0.971
NCOR2	THRB	0.971
AKT1	CREBBP	0.971
NCOA1	NRIP1	0.971
NCOA1	THRB	0.97
NCOA3	MED1	0.97
NCOR2	NRIP1	0.97
NCOA6	MED1	0.97
THRB	RXRG	0.97
NCOA2	NCOR1	0.969
UBE2I	PML	0.969
CTCF	EP300	0.969
EP300	RARA	0.969
NCOA1	NCOA6	0.968
MAPK8	EP300	0.968
RXRG	MED1	0.968
EZH2	CREBBP	0.968
NCOA1	NCOR2	0.968
NRIP1	HDAC1	0.968
RXRA	RXRG	0.967
MED1	RARA	0.967
RXRB	MED1	0.967
NCOR2	MED1	0.967
NCOA1	MED1	0.966
NCOA6	CREBBP	0.966
RXRA	CTCF	0.966
KDM6A	SUZ12	0.966
CREBBP	RARA	0.966
NRIP1	RARA	0.966
UBE2I	SUZ12	0.965
MAPK8	NR3C1	0.965
RXRA	NCOA3	0.965
HOXB4	HOXD4	0.965
CRABP2	RARG	0.964
NCOA2	RARA	0.964
CRABP2	RARB	0.964
HDAC1	UBE2I	0.964
HDAC1	HIST2H2BE	0.964
NCOA2	NCOR2	0.964
KDM6A	EP300	0.964
NCOR2	NCOA6	0.964
NCOA3	RARA	0.964
NCOA2	MED1	0.963
NRIP1	RXRB	0.963
UBE2I	EP300	0.963
EZH2	CTCF	0.963
SUZ12	KMT2D	0.963
CREBBP	YY1	0.962
KAT2B	YY1	0.962
PML	RARA	0.962
KDM6A	CREBBP	0.962
EZH2	HDAC3	0.961
NR3C1	MAPK1	0.961
HOXB1	MEIS1	0.96
KDM6A	HDAC3	0.96
UBE2I	NR3C1	0.96
MED1	NCOR1	0.96
NCOA2	KAT2B	0.96
NCOA6	NCOA3	0.959
NCOA2	NCOA1	0.958
AKT1	RARA	0.958
NRIP1	RARB	0.958
THRB	MED1	0.958
NRIP1	MED1	0.957
HDAC3	YY1	0.957
NCOA2	NCOA6	0.957
NCOR1	KAT2B	0.957
PBX1	HOXA1	0.956
THRB	RXRB	0.956
MED1	EP300	0.955
NCOR2	UBE2I	0.955
NCOA2	NCOA3	0.955
KAT2B	RARA	0.955
NCOA1	NCOA3	0.954
UBE2I	CREBBP	0.954
ZBTB16	RARA	0.954
PML	CREBBP	0.953
KDM6A	HOXB1	0.953
HIST2H2BE	EZH2	0.953
HDAC1	PML	0.953
RXRA	NCOA6	0.953
NCOR2	MAPK1	0.952
CRABP2	RARA	0.952
HIST2H2BE	HDAC3	0.952
HOXB1	KMT2D	0.952
KDM6A	HIST2H2BE	0.952
NCOA6	RARA	0.951
MED1	CREBBP	0.951
NCOA3	RARB	0.951
CARM1	MED1	0.951
HDAC1	KMT2D	0.95
NRIP1	HDAC3	0.95
NCOR2	KAT2B	0.95
RXRA	UBE2I	0.949
EZH2	RARA	0.949
NCOR1	YY1	0.949
AKT1	EZH2	0.949
RARG	NCOA3	0.949
HOXD4	YY1	0.949
RARB	EP300	0.949
PML	EP300	0.949
RARA	NR3C1	0.948
HDAC1	HDAC3	0.948
SUZ12	EP300	0.948
RXRA	HDAC3	0.948
MAPK8	MAPK3	0.948
EZH2	NCOR1	0.948
NCOA6	NCOR1	0.948
PBX1	RARA	0.947
MAPK8	MAPK1	0.947
CARM1	NCOR1	0.946
SUZ12	HDAC3	0.946
NCOR2	NCOR1	0.946
KDM6A	CTCF	0.946
NCOR1	CTCF	0.946
KAT2B	NR3C1	0.945
RXRA	YY1	0.944
MAPK3	NR3C1	0.944
RARB	CREBBP	0.944
THRB	UBE2I	0.944
NRIP1	EP300	0.944
HDAC1	RARA	0.944
HDAC3	RARA	0.944
KMT2D	KAT2B	0.943
PRKCA	RARA	0.943
PRKCA	MAPK3	0.943
CDK7	RARA	0.943
NCOR2	CARM1	0.943
NCOA6	CARM1	0.943
EZH2	MEIS1	0.942
RXRA	SUZ12	0.942
CRABP2	RXRA	0.942
NCOA1	RXRB	0.942
KDM6A	NCOR1	0.942
RXRA	MAPK1	0.941
RARG	CREBBP	0.941
RARG	EP300	0.941
PRKCA	MAPK1	0.941
SUZ12	RARA	0.94
THRB	RARA	0.94
SUMO2	RARA	0.94
RXRA	EZH2	0.94
RARG	AJUBA	0.94
RARA	MAPK1	0.939
RARG	NRIP1	0.939
NRIP1	CREBBP	0.939
NRIP1	RXRG	0.939
CCNH	RARA	0.939
AJUBA	RARA	0.938
HIST2H2BE	CTCF	0.938
RXRA	MAPK3	0.938
RARG	SUZ12	0.938
NCOA2	RARB	0.938
HOXA1	MEIS1	0.938
HIST2H2BE	KMT2D	0.936
MEIS1	RARA	0.936
PBX1	EP300	0.936
CARM1	RARA	0.935
HOXB4	EP300	0.935
CARM1	NR3C1	0.935
KDM6A	YY1	0.935
SUMO2	HIST2H2BE	0.934
UBE2I	RARA	0.934
HIST2H2BE	UBE2I	0.934
KMT2D	CTCF	0.933
PBX1	RARG	0.933
NCOA2	RXRB	0.933
RXRA	KAT2B	0.933
HIST2H2BE	NCOR1	0.932
HIST2H2BE	SUZ12	0.932
CRABP2	RXRG	0.932
RARG	MED1	0.931
SUZ12	MEIS1	0.931
HOXB1	SUZ12	0.931
HOXB1	EP300	0.93
EZH2	KMT2D	0.93
RXRA	KMT2D	0.93
AKT1	RXRA	0.93
SUZ12	CREBBP	0.93
AKT1	PML	0.929
HOXB1	EZH2	0.928
EP300	CDK7	0.928
RARB	HOXD4	0.928
HOXB3	EZH2	0.928
HOXB3	HOXB1	0.928
NCOA2	RARG	0.928
HOXB3	EP300	0.928
NCOA3	EZH2	0.927
KMT2D	MEIS1	0.927
NCOA3	YY1	0.926
RXRG	HDAC3	0.926
KMT2D	YY1	0.926
NRIP1	UBE2I	0.926
RARB	EZH2	0.926
HDAC3	KMT2D	0.926
NCOR2	HIST2H2BE	0.926
HIST2H2BE	YY1	0.926
RXRA	KDM6A	0.925
SUZ12	NCOR1	0.925
NCOA6	HDAC3	0.924
HOXB3	HOXA1	0.924
HDAC3	MED1	0.924
RXRA	CARM1	0.924
KDM6A	MEIS1	0.924
RXRB	HDAC3	0.924
SUMO2	NR3C1	0.924
RXRA	PBX1	0.924
RARB	HOXB4	0.924
CTCF	RARA	0.924
HOXD4	CREBBP	0.924
HOXB1	RARA	0.924
HOXD4	EP300	0.924
RXRA	NR3C1	0.923
KDM6A	RARA	0.923
HDAC1	MED1	0.923
RXRA	MAPK8	0.923
AKT1	NRIP1	0.923
NCOA2	UBE2I	0.923
NCOA6	EZH2	0.922
PBX1	EZH2	0.922
MAPK8	HIST2H2BE	0.921
NCOA2	RXRG	0.921
NCOA1	HDAC3	0.921
NCOA3	KMT2D	0.921
CRABP2	RXRB	0.921
YY1	RARA	0.921
MEIS1	EP300	0.92
RXRA	HDAC1	0.92
PBX1	NCOR1	0.92
AKT1	RARB	0.92
AKT1	RARG	0.92
RARG	HOXB1	0.919
EP300	CCNH	0.919
KMT2D	RARA	0.919
HOXA4	RARB	0.919
HOXA1	RARA	0.919
NCOR2	MAPK3	0.919
MAPK3	RARA	0.919
HDAC1	RARB	0.918
HIST2H2BE	RARA	0.918
HOXA4	RARA	0.918
RARB	KAT2B	0.918
NCOA3	SUZ12	0.918
MAPK8	RARA	0.918
MNAT1	RARA	0.917
NCOA3	HDAC3	0.917
NCOA3	CTCF	0.917
PBX1	KMT2D	0.917
RARG	KAT2B	0.916
RXRA	HOXB3	0.916
RXRG	NCOR1	0.916
NCOA3	HIST2H2BE	0.916
PBX1	CTCF	0.916
HOXB3	NCOR1	0.916
NRIP1	MAPK3	0.916
HOXB4	RARA	0.916
HOXD4	RARA	0.916
RARG	MEIS1	0.915
HOXB3	RARA	0.915
HOXB3	SUZ12	0.915
HIST2H2BE	RARB	0.915
RARG	HIST2H2BE	0.915
NRIP1	MAPK1	0.914
RARB	MAPK3	0.914
PBX1	SUZ12	0.913
PBX1	NCOA3	0.913
MEIS1	NCOR1	0.913
HOXB3	RARG	0.913
AKT1	RXRB	0.912
RXRA	MEIS1	0.912
KDM6A	RARB	0.912
PBX1	KDM6A	0.912
KDM6A	AJUBA	0.912
RXRA	HOXA4	0.912
HOXB1	HOXA1	0.912
RARB	SUZ12	0.911
KDM6A	HOXD4	0.911
HOXA1	EZH2	0.911
RARB	CTCF	0.911
RXRA	HOXB1	0.911
NCOA1	UBE2I	0.911
RXRA	CCNH	0.91
HIST2H2BE	MEIS1	0.91
HOXB1	NCOR1	0.91
EZH2	AJUBA	0.91
NCOA3	HOXA1	0.91
NCOA1	RXRG	0.91
RARB	MAPK1	0.91
NCOA3	MEIS1	0.91
NCOA6	SUZ12	0.91
HOXA4	CTCF	0.91
CARM1	HDAC3	0.91
HOXA1	NCOR1	0.909
KDM6A	HOXB4	0.909
SUZ12	AJUBA	0.909
RARG	CCNH	0.909
KDM6A	NCOA3	0.909
KMT2D	AJUBA	0.909
RARG	KDM6A	0.909
NCOA6	HIST2H2BE	0.909
AKT1	RXRG	0.908
RXRA	PRKCA	0.908
HOXB3	KMT2D	0.908
HOXB1	CTCF	0.908
NCOR1	AJUBA	0.908
RARB	KMT2D	0.908
THRB	RARB	0.908
RARG	EZH2	0.908
RARB	YY1	0.907
RARG	CDK7	0.907
RXRB	MAPK1	0.907
AKT1	MAPK3	0.907
NCOA2	HDAC3	0.907
RARG	MAPK1	0.907
RXRA	HOXD4	0.907
RARG	THRB	0.907
RXRA	HOXB4	0.906
EP300	AJUBA	0.906
RXRB	HDAC1	0.906
HOXA1	SUZ12	0.906
NCOA3	HOXB1	0.905
HOXA4	EP300	0.905
HOXD4	KMT2D	0.905
HIST2H2BE	HOXB4	0.905
RXRA	AJUBA	0.905
HOXA1	KMT2D	0.905
RXRA	RXRB	0.905
RARG	MAPK3	0.905
HIST2H2BE	HOXB1	0.905
AKT1	MAPK1	0.905
HOXB4	KMT2D	0.904
RXRG	MAPK3	0.904
RXRB	MAPK3	0.904
RXRG	MAPK1	0.904
NCOA6	YY1	0.904
HOXB3	HIST2H2BE	0.904
RARG	KMT2D	0.903
RXRB	RXRG	0.903
RARG	NCOA6	0.903
RARG	HDAC1	0.903
NCOA6	CTCF	0.903
RXRA	HOXA1	0.903
RARB	HDAC3	0.903
RARG	HOXA1	0.903
HOXA1	EP300	0.903
NCOA3	HOXA4	0.903
RARG	RARB	0.902
HDAC1	RXRG	0.902
PBX1	HIST2H2BE	0.902
NCOA6	HOXD4	0.902
HOXB3	KDM6A	0.902
NCOA6	AJUBA	0.902
KDM6A	HOXA1	0.902
RARG	MNAT1	0.902
PBX1	NCOA6	0.902
NCOR2	NR3C1	0.901
HOXB3	NCOA3	0.901
RARG	HDAC3	0.9
NCOA3	HOXD4	0.9
HIST2H2BE	HOXA1	0.9
NCOA6	HOXA1	0.9
HDAC3	AJUBA	0.9
PRKCA	RXRB	0.9
HIST2H2BE	HOXD4	0.9
NCOA3	HOXB4	0.9
NCOA6	HOXB4	0.9
HOXB3	NCOA6	0.9
NCOA6	RARB	0.9
PRKCA	RXRG	0.9
RXRA	HIST2H2BE	0.9
NCOA6	HOXB1	0.9
NCOA6	MEIS1	0.9
EP300	MNAT1	0.9
HIST2H2BE	AJUBA	0.9
NCOA3	AJUBA	0.9
HIST2H2BE	HOXA4	0.9

Gene Ontology Semantic Similarity

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#	902 (CCNH)	9612 (NCOR2)	4331 (MNAT1)	8648 (NCOA1)	6613 (SUMO2)	8202 (NCOA3)	2146 (EZH2)	10499 (NCOA2)	6256 (RXRA)	6257 (RXRB)	9611 (NCOR1)	7403 (KDM6A)	5916 (RARG)	3065 (HDAC1)	8841 (HDAC3)	5087 (PBX1)	8085 (KMT2D)	8850 (KAT2B)	5915 (RARB)	2033 (EP300)	8349 (HIST2H2BE)	5595 (MAPK3)	10498 (CARM1)	23512 (SUZ12)	6258 (RXRG)	23054 (NCOA6)	1387 (CREBBP)	207 (AKT1)	8204 (NRIP1)	7068 (THRB)	7329 (UBE2I)	10664 (CTCF)	5599 (MAPK8)	5469 (MED1)	3214 (HOXB4)	1382 (CRABP2)	5371 (PML)	2908 (NR3C1)	3211 (HOXB1)	7704 (ZBTB16)	3233 (HOXD4)	5914 (RARA)	5578 (PRKCA)	1022 (CDK7)	84962 (AJUBA)	3198 (HOXA1)	4211 (MEIS1)	3213 (HOXB3)	7528 (YY1)	3201 (HOXA4)	5594 (MAPK1)
902 (CCNH)	1.00	0.48	0.81	0.50	0.49	0.43	0.34	0.47	0.40	0.31	0.43	0.27	0.36	0.49	0.54	0.38	0.38	0.47	0.28	0.41	0.37	0.69	0.36	0.42	0.43	0.46	0.43	0.64	0.42	0.38	0.54	0.32	0.69	0.44	0.28	0.47	0.53	0.37	0.29	0.41	0.28	0.43	0.69	0.76	0.48	0.44	0.42	0.18	0.33	0.28	0.73
9612 (NCOR2)	0.48	1.00	0.53	0.78	0.61	0.69	0.66	0.75	0.76	0.75	0.94	0.52	0.74	0.70	0.72	0.77	0.74	0.61	0.67	0.60	0.88	0.51	0.55	0.56	0.67	0.73	0.68	0.48	0.75	0.76	0.61	0.80	0.51	0.78	0.61	0.56	0.61	0.66	0.69	0.76	0.61	0.74	0.47	0.50	0.68	0.78	0.76	0.47	0.77	0.61	0.49
4331 (MNAT1)	0.81	0.53	1.00	0.55	0.54	0.48	0.38	0.51	0.47	0.36	0.47	0.29	0.40	0.52	0.57	0.44	0.42	0.44	0.32	0.43	0.37	0.71	0.39	0.48	0.51	0.50	0.45	0.62	0.46	0.41	0.58	0.46	0.66	0.46	0.32	0.54	0.56	0.40	0.33	0.45	0.32	0.45	0.71	0.78	0.55	0.49	0.49	0.18	0.42	0.32	0.75
8648 (NCOA1)	0.50	0.78	0.55	1.00	0.58	0.85	0.50	0.95	0.67	0.76	0.73	0.28	0.71	0.59	0.67	0.64	0.69	0.61	0.62	0.58	0.37	0.54	0.57	0.52	0.68	0.84	0.64	0.50	0.82	0.71	0.60	0.64	0.52	0.81	0.53	0.58	0.70	0.60	0.54	0.63	0.53	0.72	0.49	0.63	0.68	0.68	0.66	0.36	0.60	0.53	0.52
6613 (SUMO2)	0.49	0.61	0.54	0.58	1.00	0.50	0.48	0.57	0.55	0.44	0.58	0.41	0.53	0.57	0.61	0.60	0.55	0.47	0.48	0.48	0.75	0.54	0.44	0.56	0.60	0.56	0.53	0.50	0.52	0.54	0.71	0.50	0.50	0.52	0.43	0.62	0.66	0.47	0.48	0.59	0.43	0.54	0.47	0.43	0.62	0.62	0.67	0.26	0.54	0.43	0.51
8202 (NCOA3)	0.43	0.69	0.48	0.85	0.50	1.00	0.46	0.81	0.64	0.68	0.67	0.26	0.64	0.54	0.58	0.56	0.61	0.68	0.56	0.66	0.37	0.48	0.53	0.45	0.58	0.73	0.69	0.46	0.72	0.63	0.53	0.57	0.45	0.75	0.46	0.49	0.63	0.54	0.48	0.57	0.46	0.67	0.43	0.57	0.59	0.59	0.56	0.32	0.56	0.46	0.46
2146 (EZH2)	0.34	0.66	0.38	0.50	0.48	0.46	1.00	0.48	0.63	0.57	0.64	0.62	0.61	0.60	0.53	0.66	0.80	0.47	0.56	0.56	1.00	0.43	0.65	0.79	0.47	0.49	0.63	0.42	0.46	0.60	0.53	0.65	0.40	0.57	0.51	0.37	0.46	0.59	0.65	0.66	0.51	0.61	0.37	0.37	0.38	0.61	0.60	0.49	0.65	0.51	0.42
10499 (NCOA2)	0.47	0.75	0.51	0.95	0.57	0.81	0.48	1.00	0.67	0.79	0.71	0.28	0.72	0.56	0.65	0.65	0.70	0.60	0.65	0.54	0.37	0.51	0.57	0.50	0.71	0.80	0.64	0.47	0.77	0.71	0.58	0.64	0.47	0.80	0.56	0.57	0.71	0.59	0.59	0.64	0.56	0.72	0.45	0.57	0.71	0.70	0.67	0.41	0.60	0.56	0.49
6256 (RXRA)	0.40	0.76	0.47	0.67	0.55	0.64	0.63	0.67	1.00	0.77	0.77	0.45	0.81	0.66	0.52	0.75	0.74	0.48	0.76	0.57	1.00	0.44	0.57	0.49	0.55	0.56	0.67	0.44	0.61	0.80	0.56	0.81	0.44	0.78	0.59	0.46	0.52	0.72	0.71	0.75	0.59	0.85	0.41	0.44	0.48	0.70	0.71	0.48	0.82	0.59	0.43
6257 (RXRB)	0.31	0.75	0.36	0.76	0.44	0.68	0.57	0.79	0.77	1.00	0.72	0.35	0.87	0.60	0.51	0.82	0.73	0.46	0.85	0.47	0.49	0.39	0.47	0.36	0.72	0.55	0.67	0.37	0.58	0.84	0.45	0.75	0.36	0.74	0.79	0.37	0.53	0.76	0.79	0.76	0.79	0.81	0.33	0.40	0.49	0.77	0.73	0.74	0.75	0.79	0.37
9611 (NCOR1)	0.43	0.94	0.47	0.73	0.58	0.67	0.64	0.71	0.77	0.72	1.00	0.52	0.74	0.71	0.69	0.73	0.73	0.59	0.68	0.63	0.88	0.47	0.56	0.52	0.61	0.72	0.71	0.45	0.74	0.76	0.60	0.80	0.47	0.79	0.64	0.50	0.57	0.65	0.67	0.74	0.64	0.74	0.43	0.47	0.62	0.74	0.73	0.47	0.77	0.64	0.45
7403 (KDM6A)	0.27	0.52	0.29	0.28	0.41	0.26	0.62	0.28	0.45	0.35	0.52	1.00	0.45	0.49	0.42	0.53	0.43	0.38	0.47	0.44	0.88	0.32	0.34	0.47	0.29	0.38	0.46	0.30	0.37	0.44	0.41	0.55	0.30	0.39	0.39	0.31	0.32	0.37	0.52	0.50	0.39	0.41	0.29	0.28	0.30	0.47	0.49	0.39	0.53	0.39	0.31
5916 (RARG)	0.36	0.74	0.40	0.71	0.53	0.64	0.61	0.72	0.81	0.87	0.74	0.45	1.00	0.68	0.54	0.81	0.72	0.48	0.96	0.56	1.00	0.42	0.52	0.45	0.59	0.62	0.71	0.40	0.66	0.93	0.54	0.75	0.40	0.81	0.71	0.42	0.53	0.74	0.75	0.78	0.71	0.86	0.36	0.42	0.49	0.72	0.72	0.60	0.79	0.71	0.40
3065 (HDAC1)	0.49	0.70	0.52	0.59	0.57	0.54	0.60	0.56	0.66	0.60	0.71	0.49	0.68	1.00	0.79	0.64	0.63	0.58	0.66	0.63	0.73	0.52	0.59	0.56	0.50	0.58	0.68	0.50	0.67	0.72	0.64	0.67	0.52	0.68	0.58	0.51	0.57	0.58	0.57	0.62	0.58	0.73	0.49	0.51	0.58	0.58	0.59	0.34	0.72	0.58	0.51
8841 (HDAC3)	0.54	0.72	0.57	0.67	0.61	0.58	0.53	0.65	0.52	0.51	0.69	0.42	0.54	0.79	1.00	0.52	0.55	0.68	0.48	0.55	0.37	0.58	0.52	0.57	0.58	0.73	0.62	0.54	0.64	0.61	0.67	0.55	0.58	0.65	0.43	0.60	0.66	0.46	0.40	0.51	0.43	0.62	0.53	0.54	0.73	0.56	0.57	0.20	0.50	0.43	0.56
5087 (PBX1)	0.38	0.77	0.44	0.64	0.60	0.56	0.66	0.65	0.75	0.82	0.73	0.53	0.81	0.64	0.52	1.00	0.72	0.40	0.78	0.50	1.00	0.45	0.42	0.51	0.77	0.47	0.66	0.43	0.54	0.78	0.59	0.80	0.41	0.61	0.84	0.49	0.51	0.73	0.90	0.90	0.84	0.70	0.38	0.35	0.50	0.88	0.91	0.78	0.77	0.84	0.42
8085 (KMT2D)	0.38	0.74	0.42	0.69	0.55	0.61	0.80	0.70	0.74	0.73	0.73	0.43	0.72	0.63	0.55	0.72	1.00	0.51	0.69	0.54	1.00	0.45	0.76	0.71	0.58	0.59	0.65	0.43	0.59	0.72	0.57	0.73	0.42	0.68	0.57	0.44	0.61	0.63	0.67	0.72	0.57	0.72	0.39	0.47	0.55	0.71	0.72	0.49	0.76	0.57	0.43
8850 (KAT2B)	0.47	0.61	0.44	0.61	0.47	0.68	0.47	0.60	0.48	0.46	0.59	0.38	0.48	0.58	0.68	0.40	0.51	1.00	0.43	0.74	0.37	0.49	0.53	0.47	0.43	0.67	0.77	0.49	0.56	0.52	0.56	0.46	0.51	0.63	0.31	0.44	0.62	0.41	0.31	0.41	0.31	0.58	0.45	0.53	0.56	0.43	0.42	0.18	0.46	0.31	0.48
5915 (RARB)	0.28	0.67	0.32	0.62	0.48	0.56	0.56	0.65	0.76	0.85	0.68	0.47	0.96	0.66	0.48	0.78	0.69	0.43	1.00	0.51	1.00	0.35	0.49	0.40	0.52	0.53	0.66	0.33	0.56	0.91	0.49	0.71	0.33	0.75	0.72	0.34	0.47	0.70	0.76	0.73	0.72	0.81	0.29	0.35	0.44	0.69	0.68	0.62	0.77	0.72	0.33
2033 (EP300)	0.41	0.60	0.43	0.58	0.48	0.66	0.56	0.54	0.57	0.47	0.63	0.44	0.56	0.63	0.55	0.50	0.54	0.74	0.51	1.00	1.00	0.48	0.55	0.48	0.41	0.57	0.79	0.47	0.61	0.56	0.56	0.52	0.47	0.64	0.40	0.41	0.54	0.46	0.45	0.51	0.40	0.58	0.44	0.55	0.46	0.47	0.48	0.24	0.59	0.40	0.48
8349 (HIST2H2BE)	0.37	0.88	0.37	0.37	0.75	0.37	1.00	0.37	1.00	0.49	0.88	0.88	1.00	0.73	0.37	1.00	1.00	0.37	1.00	1.00	1.00	0.37	0.73	0.68	0.37	0.37	0.88	0.37	0.43	1.00	0.75	0.88	0.37	0.67	0.49	0.37	0.37	0.67	1.00	1.00	0.49	0.68	0.37	0.37	0.37	0.88	1.00	0.43	1.00	0.49	0.37
5595 (MAPK3)	0.69	0.51	0.71	0.54	0.54	0.48	0.43	0.51	0.44	0.39	0.47	0.32	0.42	0.52	0.58	0.45	0.45	0.49	0.35	0.48	0.37	1.00	0.46	0.53	0.52	0.52	0.49	0.77	0.47	0.44	0.64	0.38	0.88	0.47	0.33	0.54	0.62	0.42	0.34	0.49	0.33	0.47	0.84	0.78	0.55	0.53	0.50	0.19	0.37	0.33	0.99
10498 (CARM1)	0.36	0.55	0.39	0.57	0.44	0.53	0.65	0.57	0.57	0.47	0.56	0.34	0.52	0.59	0.52	0.42	0.76	0.53	0.49	0.55	0.73	0.46	1.00	0.68	0.36	0.56	0.55	0.44	0.55	0.54	0.52	0.49	0.43	0.60	0.31	0.37	0.61	0.41	0.36	0.44	0.31	0.59	0.40	0.51	0.49	0.41	0.41	0.22	0.56	0.31	0.45
23512 (SUZ12)	0.42	0.56	0.48	0.52	0.56	0.45	0.79	0.50	0.49	0.36	0.52	0.47	0.45	0.56	0.57	0.51	0.71	0.47	0.40	0.48	0.68	0.53	0.68	1.00	0.49	0.52	0.50	0.48	0.46	0.46	0.61	0.48	0.48	0.48	0.34	0.52	0.57	0.42	0.41	0.51	0.34	0.52	0.44	0.43	0.52	0.53	0.56	0.21	0.45	0.34	0.50
6258 (RXRG)	0.43	0.67	0.51	0.68	0.60	0.58	0.47	0.71	0.55	0.72	0.61	0.29	0.59	0.50	0.58	0.77	0.58	0.43	0.52	0.41	0.37	0.52	0.36	0.49	1.00	0.53	0.55	0.45	0.48	0.58	0.59	0.58	0.45	0.54	0.73	0.66	0.59	0.62	0.65	0.70	0.73	0.57	0.41	0.37	0.64	0.86	0.87	0.65	0.49	0.73	0.47
23054 (NCOA6)	0.46	0.73	0.50	0.84	0.56	0.73	0.49	0.80	0.56	0.55	0.72	0.38	0.62	0.58	0.73	0.47	0.59	0.67	0.53	0.57	0.37	0.52	0.56	0.52	0.53	1.00	0.62	0.48	0.83	0.60	0.60	0.51	0.49	0.79	0.37	0.55	0.71	0.43	0.36	0.47	0.37	0.64	0.46	0.58	0.69	0.51	0.52	0.18	0.50	0.37	0.49
1387 (CREBBP)	0.43	0.68	0.45	0.64	0.53	0.69	0.63	0.64	0.67	0.67	0.71	0.46	0.71	0.68	0.62	0.66	0.65	0.77	0.66	0.79	0.88	0.49	0.55	0.50	0.55	0.62	1.00	0.47	0.59	0.71	0.59	0.69	0.47	0.70	0.56	0.46	0.59	0.59	0.59	0.66	0.56	0.70	0.45	0.51	0.53	0.62	0.61	0.42	0.75	0.56	0.48
207 (AKT1)	0.64	0.48	0.62	0.50	0.50	0.46	0.42	0.47	0.44	0.37	0.45	0.30	0.40	0.50	0.54	0.43	0.43	0.49	0.33	0.47	0.37	0.77	0.44	0.48	0.45	0.48	0.47	1.00	0.44	0.42	0.58	0.38	0.77	0.45	0.31	0.47	0.59	0.41	0.33	0.49	0.31	0.46	0.75	0.71	0.47	0.48	0.45	0.18	0.37	0.31	0.77
8204 (NRIP1)	0.42	0.75	0.46	0.82	0.52	0.72	0.46	0.77	0.61	0.58	0.74	0.37	0.66	0.67	0.64	0.54	0.59	0.56	0.56	0.61	0.43	0.47	0.55	0.46	0.48	0.83	0.59	0.44	1.00	0.64	0.53	0.61	0.43	0.77	0.43	0.50	0.65	0.49	0.49	0.52	0.43	0.67	0.41	0.60	0.69	0.51	0.50	0.30	0.64	0.43	0.45
7068 (THRB)	0.38	0.76	0.41	0.71	0.54	0.63	0.60	0.71	0.80	0.84	0.76	0.44	0.93	0.72	0.61	0.78	0.72	0.52	0.91	0.56	1.00	0.44	0.54	0.46	0.58	0.60	0.71	0.42	0.64	1.00	0.56	0.78	0.43	0.79	0.66	0.43	0.56	0.73	0.72	0.75	0.66	0.87	0.39	0.44	0.57	0.70	0.69	0.56	0.81	0.66	0.42
7329 (UBE2I)	0.54	0.61	0.58	0.60	0.71	0.53	0.53	0.58	0.56	0.45	0.60	0.41	0.54	0.64	0.67	0.59	0.57	0.56	0.49	0.56	0.75	0.64	0.52	0.61	0.59	0.60	0.59	0.58	0.53	0.56	1.00	0.51	0.62	0.54	0.44	0.61	0.75	0.48	0.49	0.58	0.44	0.56	0.58	0.53	0.61	0.61	0.64	0.22	0.54	0.44	0.62
10664 (CTCF)	0.32	0.80	0.46	0.64	0.50	0.57	0.65	0.64	0.81	0.75	0.80	0.55	0.75	0.67	0.55	0.80	0.73	0.46	0.71	0.52	0.88	0.38	0.49	0.48	0.58	0.51	0.69	0.38	0.61	0.78	0.51	1.00	0.36	0.68	0.66	0.38	0.49	0.69	0.76	0.78	0.66	0.77	0.34	0.37	0.52	0.75	0.73	0.66	0.89	0.66	0.36
5599 (MAPK8)	0.69	0.51	0.66	0.52	0.50	0.45	0.40	0.47	0.44	0.36	0.47	0.30	0.40	0.52	0.58	0.41	0.42	0.51	0.33	0.47	0.37	0.88	0.43	0.48	0.45	0.49	0.47	0.77	0.43	0.43	0.62	0.36	1.00	0.45	0.30	0.47	0.57	0.40	0.31	0.42	0.30	0.47	0.81	0.74	0.48	0.45	0.44	0.18	0.35	0.30	0.88
5469 (MED1)	0.44	0.78	0.46	0.81	0.52	0.75	0.57	0.80	0.78	0.74	0.79	0.39	0.81	0.68	0.65	0.61	0.68	0.63	0.75	0.64	0.67	0.47	0.60	0.48	0.54	0.79	0.70	0.45	0.77	0.79	0.54	0.68	0.45	1.00	0.53	0.48	0.62	0.64	0.57	0.61	0.53	0.80	0.43	0.56	0.59	0.59	0.58	0.35	0.70	0.53	0.46
3214 (HOXB4)	0.28	0.61	0.32	0.53	0.43	0.46	0.51	0.56	0.59	0.79	0.64	0.39	0.71	0.58	0.43	0.84	0.57	0.31	0.72	0.40	0.49	0.33	0.31	0.34	0.73	0.37	0.56	0.31	0.43	0.66	0.44	0.66	0.30	0.53	1.00	0.37	0.37	0.62	0.84	0.72	1.00	0.58	0.28	0.26	0.38	0.78	0.74	0.79	0.62	1.00	0.31
1382 (CRABP2)	0.47	0.56	0.54	0.58	0.62	0.49	0.37	0.57	0.46	0.37	0.50	0.31	0.42	0.51	0.60	0.49	0.44	0.44	0.34	0.41	0.37	0.54	0.37	0.52	0.66	0.55	0.46	0.47	0.50	0.43	0.61	0.38	0.47	0.48	0.37	1.00	0.61	0.43	0.36	0.48	0.37	0.49	0.43	0.39	0.68	0.56	0.60	0.20	0.37	0.37	0.50
5371 (PML)	0.53	0.61	0.56	0.70	0.66	0.63	0.46	0.71	0.52	0.53	0.57	0.32	0.53	0.57	0.66	0.51	0.61	0.62	0.47	0.54	0.37	0.62	0.61	0.57	0.59	0.71	0.59	0.59	0.65	0.56	0.75	0.49	0.57	0.62	0.37	0.61	1.00	0.47	0.38	0.55	0.37	0.59	0.54	0.61	0.71	0.56	0.57	0.19	0.50	0.37	0.60
2908 (NR3C1)	0.37	0.66	0.40	0.60	0.47	0.54	0.59	0.59	0.72	0.76	0.65	0.37	0.74	0.58	0.46	0.73	0.63	0.41	0.70	0.46	0.67	0.42	0.41	0.42	0.62	0.43	0.59	0.41	0.49	0.73	0.48	0.69	0.40	0.64	0.62	0.43	0.47	1.00	0.72	0.70	0.62	0.72	0.38	0.35	0.42	0.68	0.67	0.61	0.68	0.62	0.40
3211 (HOXB1)	0.29	0.69	0.33	0.54	0.48	0.48	0.65	0.59	0.71	0.79	0.67	0.52	0.75	0.57	0.40	0.90	0.67	0.31	0.76	0.45	1.00	0.34	0.36	0.41	0.65	0.36	0.59	0.33	0.49	0.72	0.49	0.76	0.31	0.57	0.84	0.36	0.38	0.72	1.00	0.81	0.84	0.65	0.29	0.28	0.37	0.82	0.80	0.83	0.74	0.84	0.32
7704 (ZBTB16)	0.41	0.76	0.45	0.63	0.59	0.57	0.66	0.64	0.75	0.76	0.74	0.50	0.78	0.62	0.51	0.90	0.72	0.41	0.73	0.51	1.00	0.49	0.44	0.51	0.70	0.47	0.66	0.49	0.52	0.75	0.58	0.78	0.42	0.61	0.72	0.48	0.55	0.70	0.81	1.00	0.72	0.69	0.40	0.38	0.49	0.89	0.85	0.64	0.78	0.72	0.47
3233 (HOXD4)	0.28	0.61	0.32	0.53	0.43	0.46	0.51	0.56	0.59	0.79	0.64	0.39	0.71	0.58	0.43	0.84	0.57	0.31	0.72	0.40	0.49	0.33	0.31	0.34	0.73	0.37	0.56	0.31	0.43	0.66	0.44	0.66	0.30	0.53	1.00	0.37	0.37	0.62	0.84	0.72	1.00	0.58	0.28	0.26	0.38	0.78	0.74	0.79	0.62	1.00	0.31
5914 (RARA)	0.43	0.74	0.45	0.72	0.54	0.67	0.61	0.72	0.85	0.81	0.74	0.41	0.86	0.73	0.62	0.70	0.72	0.58	0.81	0.58	0.68	0.47	0.59	0.52	0.57	0.64	0.70	0.46	0.67	0.87	0.56	0.77	0.47	0.80	0.58	0.49	0.59	0.72	0.65	0.69	0.58	1.00	0.44	0.50	0.58	0.65	0.64	0.44	0.77	0.58	0.46
5578 (PRKCA)	0.69	0.47	0.71	0.49	0.47	0.43	0.37	0.45	0.41	0.33	0.43	0.29	0.36	0.49	0.53	0.38	0.39	0.45	0.29	0.44	0.37	0.84	0.40	0.44	0.41	0.46	0.45	0.75	0.41	0.39	0.58	0.34	0.81	0.43	0.28	0.43	0.54	0.38	0.29	0.40	0.28	0.44	1.00	0.76	0.45	0.42	0.41	0.16	0.34	0.28	0.84
1022 (CDK7)	0.76	0.50	0.78	0.63	0.43	0.57	0.37	0.57	0.44	0.40	0.47	0.28	0.42	0.51	0.54	0.35	0.47	0.53	0.35	0.55	0.37	0.78	0.51	0.43	0.37	0.58	0.51	0.71	0.60	0.44	0.53	0.37	0.74	0.56	0.26	0.39	0.61	0.35	0.28	0.38	0.26	0.50	0.76	1.00	0.49	0.39	0.37	0.17	0.41	0.26	0.80
84962 (AJUBA)	0.48	0.68	0.55	0.68	0.62	0.59	0.38	0.71	0.48	0.49	0.62	0.30	0.49	0.58	0.73	0.50	0.55	0.56	0.44	0.46	0.37	0.55	0.49	0.52	0.64	0.69	0.53	0.47	0.69	0.57	0.61	0.52	0.48	0.59	0.38	0.68	0.71	0.42	0.37	0.49	0.38	0.58	0.45	0.49	1.00	0.57	0.60	0.21	0.48	0.38	0.51
3198 (HOXA1)	0.44	0.78	0.49	0.68	0.62	0.59	0.61	0.70	0.70	0.77	0.74	0.47	0.72	0.58	0.56	0.88	0.71	0.43	0.69	0.47	0.88	0.53	0.41	0.53	0.86	0.51	0.62	0.48	0.51	0.70	0.61	0.75	0.45	0.59	0.78	0.56	0.56	0.68	0.82	0.89	0.78	0.65	0.42	0.39	0.57	1.00	0.93	0.65	0.69	0.78	0.50
4211 (MEIS1)	0.42	0.76	0.49	0.66	0.67	0.56	0.60	0.67	0.71	0.73	0.73	0.49	0.72	0.59	0.57	0.91	0.72	0.42	0.68	0.48	1.00	0.50	0.41	0.56	0.87	0.52	0.61	0.45	0.50	0.69	0.64	0.73	0.44	0.58	0.74	0.60	0.57	0.67	0.80	0.85	0.74	0.64	0.41	0.37	0.60	0.93	1.00	0.66	0.69	0.74	0.46
3213 (HOXB3)	0.18	0.47	0.18	0.36	0.26	0.32	0.49	0.41	0.48	0.74	0.47	0.39	0.60	0.34	0.20	0.78	0.49	0.18	0.62	0.24	0.43	0.19	0.22	0.21	0.65	0.18	0.42	0.18	0.30	0.56	0.22	0.66	0.18	0.35	0.79	0.20	0.19	0.61	0.83	0.64	0.79	0.44	0.16	0.17	0.21	0.65	0.66	1.00	0.58	0.79	0.18
7528 (YY1)	0.33	0.77	0.42	0.60	0.54	0.56	0.65	0.60	0.82	0.75	0.77	0.53	0.79	0.72	0.50	0.77	0.76	0.46	0.77	0.59	1.00	0.37	0.56	0.45	0.49	0.50	0.75	0.37	0.64	0.81	0.54	0.89	0.35	0.70	0.62	0.37	0.50	0.68	0.74	0.78	0.62	0.77	0.34	0.41	0.48	0.69	0.69	0.58	1.00	0.62	0.36
3201 (HOXA4)	0.28	0.61	0.32	0.53	0.43	0.46	0.51	0.56	0.59	0.79	0.64	0.39	0.71	0.58	0.43	0.84	0.57	0.31	0.72	0.40	0.49	0.33	0.31	0.34	0.73	0.37	0.56	0.31	0.43	0.66	0.44	0.66	0.30	0.53	1.00	0.37	0.37	0.62	0.84	0.72	1.00	0.58	0.28	0.26	0.38	0.78	0.74	0.79	0.62	1.00	0.31
5594 (MAPK1)	0.73	0.49	0.75	0.52	0.51	0.46	0.42	0.49	0.43	0.37	0.45	0.31	0.40	0.51	0.56	0.42	0.43	0.48	0.33	0.48	0.37	0.99	0.45	0.50	0.47	0.49	0.48	0.77	0.45	0.42	0.62	0.36	0.88	0.46	0.31	0.50	0.60	0.40	0.32	0.47	0.31	0.46	0.84	0.80	0.51	0.50	0.46	0.18	0.36	0.31	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
RARA	Human	Blood	-	3650 m	48 hours	downregulated	0.65	Microarray	Himalayas	Indians	1	HAPE Pateints Vs Normal	http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
EBF1	1879	RARA	5914	proximal_filtered	22955619	TRANSFAC
EP300	2033	RARA	5914	proximal_filtered	22955619	TRANSFAC
ESR1	2099	RARA	5914	proximal_filtered	22955619	TRANSFAC
NR3C1	2908	RARA	5914	proximal_filtered	22955619	TRANSFAC
NFKB1	4790	RARA	5914	proximal_filtered	22955619	TRANSFAC
RAD21	5885	RARA	5914	proximal_filtered	22955619	TRANSFAC
TFAP2C	7022	RARA	5914	proximal_filtered	22955619	TRANSFAC
RARA	5914	CXCR5	643	Repression	11912153	TRUSST
RARA	5914	CDKN1A	1026	Repression	22247069	TRUSST
RARA	5914	CRABP1	1381	Unknown	10649433	TRUSST
RARA	5914	CRH	1392	Unknown	9841868	TRUSST
RARA	5914	CYP1A1	1543	Repression	12888570	TRUSST
RARA	5914	ETS1	2113	Activation	22641673	TRUSST
RARA	5914	HCK	3055	Unknown	17786630	TRUSST
RARA	5914	GNRH2	2797	Unknown	7624145	TRUSST
RARA	5914	HSD17B2	3294	Unknown	11112786	TRUSST
RARA	5914	HNF4A	3172	Unknown	20382118	TRUSST
RARA	5914	ICAM1	3383	Unknown	21993313	TRUSST
RARA	5914	MAOB	4129	Activation	10229837	TRUSST
RARA	5914	MUC5AC	4586	Activation	8955077	TRUSST
RARA	5914	PLAU	5328	Repression	12032779	TRUSST
RARA	5914	PRKCA	5578	Repression	11387332	TRUSST
KLF4	9314	RARA	5914	Unknown	10527846	TRUSST
CREBBP	1387	RARA	5914	Unknown	10218980	TRUSST
JUN	3725	RARA	5914	Unknown	10218980	TRUSST
SP1	6667	RARA	5914	Activation	21734268	TRUSST
RARA	5914	SCD	6319	Unknown	17660446	TRUSST
CRABP2	1382	RARA	5914	Unknown	10218980	TRUSST
RARA	5914	RARB	5915	Activation	16488890	TRUSST
RARA	5914	SFTPB	6439	Unknown	11899260	TRUSST
RARA	5914	THBD	7056	Repression	12859951	TRUSST
RARA	5914	CCNA1	8900	Repression	19874710	TRUSST
RARA	5914	ABCC3	8714	Repression	8223441	TRUSST
RARA	5914	NR1I3	9970	Activation	9645961	TRUSST
RARA	5914	FGFBP1	9982	Unknown	15764709	TRUSST
RARA	5914	MACROD1	28992	Repression	20007691	TRUSST
RARA	5914	RPTOR	57521	Activation	17069796	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT004389	hsa-miR-125a-5p	Homo sapiens	RARA	5914	Homo sapiens	Microarray//Northern blot	Functional MTI (Weak)	16331254
MIRT024237	hsa-miR-218-5p	Homo sapiens	RARA	5914	Homo sapiens	Sequencing	Functional MTI (Weak)	20371350
MIRT039873	hsa-miR-615-3p	Homo sapiens	RARA	5914	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT045829	hsa-miR-138-5p	Homo sapiens	RARA	5914	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT045829	hsa-miR-138-5p	Homo sapiens	RARA	5914	Homo sapiens	Luciferase reporter assay//Western blot	Functional MTI	25680531
MIRT469558	hsa-miR-4271	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469562	hsa-miR-4747-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469566	hsa-miR-6130	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469570	hsa-miR-4419a	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469573	hsa-miR-766-3p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469574	hsa-miR-194-3p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469551	hsa-miR-1273h-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469552	hsa-miR-519e-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469563	hsa-miR-6797-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469564	hsa-miR-1249-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469567	hsa-miR-6129	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469577	hsa-miR-4739	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469549	hsa-miR-3689a-3p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469565	hsa-miR-6133	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469576	hsa-miR-4756-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469578	hsa-miR-1321	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469554	hsa-miR-6778-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469556	hsa-miR-6780b-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469548	hsa-miR-3689b-3p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469557	hsa-miR-4725-3p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469572	hsa-miR-3925-3p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469580	hsa-miR-6893-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469550	hsa-miR-30b-3p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469547	hsa-miR-3689c	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469553	hsa-miR-515-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469545	hsa-miR-6780a-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469559	hsa-miR-6799-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469560	hsa-miR-5196-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469571	hsa-miR-605-3p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469546	hsa-miR-6779-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469581	hsa-miR-3714	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469569	hsa-miR-4510	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469579	hsa-miR-940	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469555	hsa-miR-1233-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469561	hsa-miR-7106-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469568	hsa-miR-6127	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469575	hsa-miR-6783-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT469582	hsa-miR-6808-5p	Homo sapiens	RARA	5914	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT733217	hsa-miR-27a-3p	Homo sapiens	RARA	5914	Homo sapiens	Luciferase reporter assay//Microarray//qRT-PCR	Functional MTI	25915942

Gene Ontology

ID	GO ID	GO Term	GO Type
5914	GO:0001657	ureteric bud development	GOTERM_BP_DIRECT
5914	GO:0001889	liver development	GOTERM_BP_DIRECT
5914	GO:0005634	nucleus	GOTERM_CC_DIRECT
5914	GO:0043277	apoptotic cell clearance	GOTERM_BP_DIRECT
5914	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
5914	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GOTERM_MF_DIRECT
5914	GO:0043066	negative regulation of apoptotic process	GOTERM_BP_DIRECT
5914	GO:0007283	spermatogenesis	GOTERM_BP_DIRECT
5914	GO:0045630	positive regulation of T-helper 2 cell differentiation	GOTERM_BP_DIRECT
5914	GO:0008144	drug binding	GOTERM_MF_DIRECT
5914	GO:0031490	chromatin DNA binding	GOTERM_MF_DIRECT
5914	GO:0030425	dendrite	GOTERM_CC_DIRECT
5914	GO:0021766	hippocampus development	GOTERM_BP_DIRECT
5914	GO:0032736	positive regulation of interleukin-13 production	GOTERM_BP_DIRECT
5914	GO:0032754	positive regulation of interleukin-5 production	GOTERM_BP_DIRECT
5914	GO:0048167	regulation of synaptic plasticity	GOTERM_BP_DIRECT
5914	GO:0000790	nuclear chromatin	GOTERM_CC_DIRECT
5914	GO:0019899	enzyme binding	GOTERM_MF_DIRECT
5914	GO:0007281	germ cell development	GOTERM_BP_DIRECT
5914	GO:0031641	regulation of myelination	GOTERM_BP_DIRECT
5914	GO:0045893	positive regulation of transcription	GOTERM_BP_DIRECT
5914	GO:0060534	trachea cartilage development	GOTERM_BP_DIRECT
5914	GO:0042826	histone deacetylase binding	GOTERM_MF_DIRECT
5914	GO:0015629	actin cytoskeleton	GOTERM_CC_DIRECT
5914	GO:0055012	ventricular cardiac muscle cell differentiation	GOTERM_BP_DIRECT
5914	GO:0001972	fibronectin binding	GOTERM_MF_DIRECT
5914	GO:0005515	protein binding	GOTERM_MF_DIRECT
5914	GO:0046982	protein heterodimerization activity	GOTERM_MF_DIRECT
5914	GO:0008285	negative regulation of cell proliferation	GOTERM_BP_DIRECT
5914	GO:0045666	positive regulation of neuron differentiation	GOTERM_BP_DIRECT
5914	GO:0003707	steroid hormone receptor activity	GOTERM_MF_DIRECT
5914	GO:0003708	steroid hormone receptor activity	GOTERM_MF_DIRECT
5914	GO:0008134	transcription factor binding	GOTERM_MF_DIRECT
5914	GO:0019904	protein domain specific binding	GOTERM_MF_DIRECT
5914	GO:0048027	CCR chemokine receptor binding	GOTERM_MF_DIRECT
5914	GO:0051393	NAD binding	GOTERM_MF_DIRECT
5914	GO:0048471	perinuclear region of cytoplasm	GOTERM_CC_DIRECT
5914	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
5914	GO:0001843	neural tube closure	GOTERM_BP_DIRECT
5914	GO:0030853	negative regulation of granulocyte differentiation	GOTERM_BP_DIRECT
5914	GO:0032355	response to estradiol	GOTERM_BP_DIRECT
5914	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
5914	GO:0003148	outflow tract septum morphogenesis	GOTERM_BP_DIRECT
5914	GO:0030852	regulation of granulocyte differentiation	GOTERM_BP_DIRECT
5914	GO:0003713	transcription coactivator activity	GOTERM_MF_DIRECT
5914	GO:0005102	receptor binding	GOTERM_MF_DIRECT
5914	GO:0005654	nucleoplasm	GOTERM_CC_DIRECT
5914	GO:0007565	female pregnancy	GOTERM_BP_DIRECT
5914	GO:0031076	embryonic camera-type eye development	GOTERM_BP_DIRECT
5914	GO:0071391	cellular response to estrogen stimulus	GOTERM_BP_DIRECT
5914	GO:0007165	signal transduction	GOTERM_BP_DIRECT
5914	GO:0043401	steroid hormone mediated signaling pathway	GOTERM_BP_DIRECT
5914	GO:0045471	response to ethanol	GOTERM_BP_DIRECT
5914	GO:0051099	positive regulation of binding	GOTERM_BP_DIRECT
5914	GO:0060010	Sertoli cell fate commitment	GOTERM_BP_DIRECT
5914	GO:0060591	chondroblast differentiation	GOTERM_BP_DIRECT
5914	GO:0043422	heparan sulfate proteoglycan binding	GOTERM_MF_DIRECT
5914	GO:0006351	transcription	GOTERM_BP_DIRECT
5914	GO:0030850	prostate gland development	GOTERM_BP_DIRECT
5914	GO:0032689	negative regulation of interferon-gamma production	GOTERM_BP_DIRECT
5914	GO:0032720	negative regulation of tumor necrosis factor production	GOTERM_BP_DIRECT
5914	GO:0045892	negative regulation of transcription	GOTERM_BP_DIRECT
5914	GO:0071300	cellular response to retinoic acid	GOTERM_BP_DIRECT
5914	GO:0000900	bubble DNA binding	GOTERM_MF_DIRECT
5914	GO:0003714	transcription corepressor activity	GOTERM_MF_DIRECT
5914	GO:0008270	zinc ion binding	GOTERM_MF_DIRECT
5914	GO:0043565	sequence-specific DNA binding	GOTERM_MF_DIRECT
5914	GO:0051018	actin filament binding	GOTERM_MF_DIRECT
5914	GO:0002068	glandular epithelial cell development	GOTERM_BP_DIRECT
5914	GO:0006468	protein phosphorylation	GOTERM_BP_DIRECT
5914	GO:0008284	positive regulation of cell proliferation	GOTERM_BP_DIRECT
5914	GO:0032526	response to retinoic acid	GOTERM_BP_DIRECT
5914	GO:0045787	positive regulation of cell cycle	GOTERM_BP_DIRECT
5914	GO:0060324	face development	GOTERM_BP_DIRECT
5914	GO:0061037	negative regulation of cartilage development	GOTERM_BP_DIRECT
5914	GO:0071222	cellular response to lipopolysaccharide	GOTERM_BP_DIRECT
5914	GO:0003417	growth plate cartilage development	GOTERM_BP_DIRECT
5914	GO:0006367	transcription initiation from RNA polymerase II promoter	GOTERM_BP_DIRECT
5914	GO:0045596	negative regulation of cell differentiation	GOTERM_BP_DIRECT
5914	GO:0048384	retinoic acid receptor signaling pathway	GOTERM_BP_DIRECT
5914	GO:0044323	transcription regulatory region DNA binding	GOTERM_MF_DIRECT
5914	GO:0009986	cell surface	GOTERM_CC_DIRECT
5914	GO:0032753	positive regulation of interleukin-4 production	GOTERM_BP_DIRECT
5914	GO:0033189	response to vitamin A	GOTERM_BP_DIRECT
5914	GO:0034097	response to cytokine	GOTERM_BP_DIRECT
5914	GO:0035264	multicellular organism growth	GOTERM_BP_DIRECT
5914	GO:0045947	negative regulation of translational initiation	GOTERM_BP_DIRECT
5914	GO:0060173	limb development	GOTERM_BP_DIRECT
5914	GO:0003700	transcription factor activity	GOTERM_MF_DIRECT
5914	GO:0043025	neuronal cell body	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
5914	hsa05200	Pathways in cancer
5914	hsa05202	Transcriptional misregulation in cancer
5914	hsa05221	Acute myeloid leukemia

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
RARA	5914	Lesion of Sciatic Nerve	C0154748	Disease or Syndrome	0.3	0.515	0.724	group
RARA	5914	Malignant Cystosarcoma Phyllodes	C0600066	Neoplastic Process	0.3	0.515	0.724	disease
RARA	5914	Neuralgia-Neuritis, Sciatic Nerve	C0751924	Disease or Syndrome	0.3	0.515	0.724	disease
RARA	5914	Sciatic Neuritis	C0242013	Disease or Syndrome	0.3	0.515	0.724	disease
RARA	5914	Breast Carcinoma	C0678222	Neoplastic Process	0.4	0.515	0.724	disease
RARA	5914	Mammary Neoplasms, Human	C1257931	Neoplastic Process	0.3	0.515	0.724	group
RARA	5914	Sciatic Nerve Palsy	C0751925	Disease or Syndrome	0.3	0.515	0.724	disease
RARA	5914	Treatment related secondary malignancy	C0877578	Neoplastic Process	0.3	0.515	0.724	phenotype
RARA	5914	Mammary Neoplasms	C1458155	Neoplastic Process	0.4	0.515	0.724	group
RARA	5914	Malignant neoplasm of breast	C0006142	Neoplastic Process	0.4	0.515	0.724	disease
RARA	5914	Liver carcinoma	C2239176	Neoplastic Process	0.35	0.515	0.724	disease
RARA	5914	Phyllodes Tumor	C0010701	Neoplastic Process	0.31	0.515	0.724	disease
RARA	5914	Neoplasms, Second Primary	C0085183	Neoplastic Process	0.3	0.515	0.724	group
RARA	5914	Neoplasms, Therapy-Associated	C0086696	Neoplastic Process	0.3	0.515	0.724	group
RARA	5914	Sciatic Neuropathy	C0149940	Disease or Syndrome	0.3	0.515	0.724	disease
RARA	5914	Fibroadenoma	C0206650	Neoplastic Process	0.32	0.515	0.724	disease
RARA	5914	Acute Promyelocytic Leukemia	C0023487	Neoplastic Process	0.7	0.515	0.724	disease
RARA	5914	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.32	0.515	0.724	disease
RARA	5914	Mood Disorders	C0525045	Mental or Behavioral Dysfunction	0.31	0.515	0.724	group

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
RARA	5914	ACITRETIN	ACITRETIN	CHEMBL1131	None
RARA	5914	ACITRETIN	ACITRETIN	CHEMBL1131	agonist
RARA	5914	ACITRETIN	ACITRETIN	CHEMBL1131	None
RARA	5914	ADAPALENE	ADAPALENE	CHEMBL1265	agonist
RARA	5914	ADAPALENE	ADAPALENE	CHEMBL1265	None
RARA	5914	AGN193109	CHEMBL358145	CHEMBL358145	antagonist
RARA	5914	ALITRETINOIN	ALITRETINOIN	CHEMBL705	agonist
RARA	5914	ALITRETINOIN	ALITRETINOIN	CHEMBL705	agonist
RARA	5914	ALITRETINOIN	ALITRETINOIN	CHEMBL705	None
RARA	5914	ALL-TRANS-RETINOIC ACID	TRETINOIN	CHEMBL38	None
RARA	5914	ALITRETINOIN	None	None	agonist
RARA	5914	ADAPALENE	ADAPALENE	CHEMBL1265	None
RARA	5914	ADAPALENE	ADAPALENE	CHEMBL1265	agonist
RARA	5914	AGN193836	CHEMBL439780	CHEMBL439780	agonist
RARA	5914	ALITRETIONINE	None	None	None
RARA	5914	ALPHA INTERFERON	CETUXIMAB	CHEMBL1201577	None
RARA	5914	ANTIESTROGENS	None	None	None
RARA	5914	Arsenic Trioxide	ARSENIC TRIOXIDE	CHEMBL1200978	None
RARA	5914	BMS493	CHEMBL472172	CHEMBL472172	antagonist
RARA	5914	BMS614	CHEMBL2385269	CHEMBL2385269	antagonist
RARA	5914	BMS753	CEFTAZIDIME	CHEMBL44354	agonist
RARA	5914	CAROTENOIDS	None	None	None
RARA	5914	CD666	None	None	agonist
RARA	5914	COLCHICINE	COLCHICINE	CHEMBL107	None
RARA	5914	DEXAMETHASONE	DEXAMETHASONE	CHEMBL384467	None
RARA	5914	DIFFERENTIATION AGENTS	None	None	None
RARA	5914	DMSO	DIMETHYL SULFOXIDE	CHEMBL504	None
RARA	5914	DOX	None	None	None
RARA	5914	ETRETINATE	ETRETINATE	CHEMBL464	agonist
RARA	5914	FENRETINIDE	FENRETINIDE	CHEMBL7301	None
RARA	5914	FENRETINIDE	FENRETINIDE	CHEMBL7301	None
RARA	5914	HMBA	HEXAMETHYLENEBISACETAMIDE	CHEMBL291481	None
RARA	5914	IL-6	None	None	None
RARA	5914	ISOTRETINOIN	ISOTRETINOIN	CHEMBL547	None
RARA	5914	ISOTRETINOIN	ISOTRETINOIN	CHEMBL547	None
RARA	5914	INSULIN	None	None	None
RARA	5914	ISOFLAVONES	ISOFLAVONE	CHEMBL366460	None
RARA	5914	IRX4310	IRX4310	CHEMBL3545173	antagonist
RARA	5914	ISOTRETINOIN	ISOTRETINOIN	CHEMBL547	agonist
RARA	5914	LGD-1550	None	None	None
RARA	5914	LG100268	CHEMBL288436	CHEMBL288436	agonist
RARA	5914	LYCOPENE	LYCOPENE	CHEMBL501174	None
RARA	5914	MELATONIN	MELATONIN	CHEMBL45	None
RARA	5914	MNU	N-METHYL-N-NITROSUREA	CHEMBL288958	None
RARA	5914	MOFAROTENE	MOFAROTENE	CHEMBL146506	modulator
RARA	5914	NALOXONE	NALOXONE	CHEMBL80	None
RARA	5914	NRX195183	NRX195183	CHEMBL107430	agonist
RARA	5914	NRX-5183	None	None	None
RARA	5914	R667	PALOVAROTENE	CHEMBL2105648	None
RARA	5914	RETINOIC ACIDS	ETRETINATE	CHEMBL464	None
RARA	5914	RETINOIC ACID	TRETINOIN	CHEMBL38	None
RARA	5914	RETINOIDS	ETRETINATE	CHEMBL464	None
RARA	5914	RO 41-5253	CEFPIRAMIDE	CHEMBL1201204	antagonist
RARA	5914	RO 40-6055	CHEMBL69367	CHEMBL69367	agonist
RARA	5914	SOY PROTEIN ISOLATE	None	None	None
RARA	5914	TAMIBAROTENE	TAMIBAROTENE	CHEMBL25202	binder
RARA	5914	TAZAROTENE	TAZAROTENE	CHEMBL1657	agonist
RARA	5914	TAMIBAROTENE	TAMIBAROTENE	CHEMBL25202	agonist
RARA	5914	TAZAROTENE	TAZAROTENE	CHEMBL1657	None
RARA	5914	TAMIBAROTENE	TAMIBAROTENE	CHEMBL25202	None
RARA	5914	TAMIBAROTENE	TAMIBAROTENE	CHEMBL25202	None
RARA	5914	TAZAROTENE	TAZAROTENE	CHEMBL1657	agonist
RARA	5914	TAZAROTENE	TAZAROTENE	CHEMBL1657	None
RARA	5914	TRIBUTYRIN	TRIBUTYRIN	CHEMBL118722	None
RARA	5914	TRETINOIN	TRETINOIN	CHEMBL38	agonist
RARA	5914	Tretinoin	TRETINOIN	CHEMBL38	None
RARA	5914	TRETINOIN	TRETINOIN	CHEMBL38	agonist
RARA	5914	TTNPB	None	None	agonist