C-C motif chemokine ligand 24

AltitudeomicsDB
Protein Official symbol CCL24
Aliases CCL24 MPIF2 SCYA24
Chromosomal Location 7
Length 119
Uniprot ID O00175
EC number None
Protein family Information(Pfam) PF00048;
PDB id 1EIG;1EIH;
InterPro ID IPR039809;IPR001811;IPR036048;
dbSNP rs2302006 rs11465293 rs11465312 rs11465313

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PRPF4 PRPF3 0.996
PRPF31 PRPF6 0.995
PRPF31 PRPF3 0.994
PRPF8 PRPF31 0.993
PRPF8 PRPF6 0.992
PRPF8 PRPF3 0.992
PRPF3 PRPF6 0.991
PRPF8 PRPF4 0.988
PRPF4 PRPF31 0.986
PRPF4 PRPF6 0.986
PRPF3 RP9 0.877
PRPF31 RP9 0.814
PRPF8 RP9 0.809
PRPF4 RP9 0.797
IMPDH1 PRPF31 0.777
RP9 BBS9 0.744
FSCN2 RP9 0.735
FKBP9 RP9 0.731
FKBP9 KBTBD2 0.725
RP9 PRPF6 0.724
FSCN2 PRPF31 0.721
KBTBD2 RP9 0.721
IMPDH1 PRPF3 0.712
FSCN2 PRPF3 0.701
IMPDH1 RP9 0.7
Gene Ontology Semantic Similarity
Download Tab separated file
# 9129 (PRPF3) 24148 (PRPF6) 26121 (PRPF31) 9128 (PRPF4) 6100 (RP9) 27241 (BBS9) 10594 (PRPF8) 3614 (IMPDH1) 25794 (FSCN2) 11328 (FKBP9)
9129 (PRPF3) 1.00 0.75 0.81 0.86 0.96 0.73 0.80 0.57 0.54 0.36
24148 (PRPF6) 0.75 1.00 0.83 0.69 0.74 0.59 0.71 0.47 0.43 0.36
26121 (PRPF31) 0.81 0.83 1.00 0.80 0.81 0.54 0.75 0.57 0.41 0.36
9128 (PRPF4) 0.86 0.69 0.80 1.00 0.87 0.62 0.77 0.54 0.46 0.36
6100 (RP9) 0.96 0.74 0.81 0.87 1.00 0.71 0.79 0.61 0.53 0.36
27241 (BBS9) 0.73 0.59 0.54 0.62 0.71 1.00 0.49 0.36 0.55 0.36
10594 (PRPF8) 0.80 0.71 0.75 0.77 0.79 0.49 1.00 0.61 0.33 0.36
3614 (IMPDH1) 0.57 0.47 0.57 0.54 0.61 0.36 0.61 1.00 0.23 0.25
25794 (FSCN2) 0.54 0.43 0.41 0.46 0.53 0.55 0.33 0.23 1.00 0.24
11328 (FKBP9) 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.25 0.24 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CCL24 Human Blood - 3250 m 4 day downregulated -1.6283 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT017589 hsa-miR-335-5p Homo sapiens CCL24 6369 Homo sapiens Microarray Functional MTI (Weak) 18185580
Gene Ontology
ID GO ID GO Term GO Type
6369 GO:0001938 positive regulation of endothelial cell proliferation GOTERM_BP_DIRECT
6369 GO:0007010 cytoskeleton organization GOTERM_BP_DIRECT
6369 GO:0050729 positive regulation of inflammatory response GOTERM_BP_DIRECT
6369 GO:0070374 positive regulation of ERK1 and ERK2 cascade GOTERM_BP_DIRECT
6369 GO:0030593 neutrophil chemotaxis GOTERM_BP_DIRECT
6369 GO:0007186 G-protein coupled receptor signaling pathway GOTERM_BP_DIRECT
6369 GO:0048245 eosinophil chemotaxis GOTERM_BP_DIRECT
6369 GO:0030838 positive regulation of actin filament polymerization GOTERM_BP_DIRECT
6369 GO:0048247 lymphocyte chemotaxis GOTERM_BP_DIRECT
6369 GO:0002548 monocyte chemotaxis GOTERM_BP_DIRECT
6369 GO:0008360 regulation of cell shape GOTERM_BP_DIRECT
6369 GO:0043547 positive regulation of GTPase activity GOTERM_BP_DIRECT
6369 GO:2000418 positive regulation of eosinophil migration GOTERM_BP_DIRECT
6369 GO:0030335 positive regulation of cell migration GOTERM_BP_DIRECT
6369 GO:0070098 chemokine-mediated signaling pathway GOTERM_BP_DIRECT
6369 GO:0048020 receptor antagonist activity GOTERM_MF_DIRECT
6369 GO:0007267 cell-cell signaling GOTERM_BP_DIRECT
6369 GO:0045766 positive regulation of angiogenesis GOTERM_BP_DIRECT
6369 GO:0008009 phospholipid transporter activity GOTERM_MF_DIRECT
6369 GO:0006935 chemotaxis GOTERM_BP_DIRECT
6369 GO:0006954 inflammatory response GOTERM_BP_DIRECT
6369 GO:0007165 signal transduction GOTERM_BP_DIRECT
6369 GO:0005615 extracellular space GOTERM_CC_DIRECT
6369 GO:0006955 immune response GOTERM_BP_DIRECT
6369 GO:0071347 cellular response to interleukin-1 GOTERM_BP_DIRECT
6369 GO:0071356 cellular response to tumor necrosis factor GOTERM_BP_DIRECT
6369 GO:0071346 cellular response to interferon-gamma GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
6369 hsa04062 Chemokine signaling pathway
6369 hsa04060 Cytokine-cytokine receptor interaction
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CCL24 6369 Dermatitis, Atopic C0011615 Disease or Syndrome 0.31 0.69 0.448 disease
CCL24 6369 Eczema, Infantile C0086196 Disease or Syndrome 0.3 0.69 0.448 disease
CCL24 6369 Pneumonia C0032285 Disease or Syndrome 0.32 0.69 0.448 disease
CCL24 6369 Pneumonitis C3714636 Disease or Syndrome 0.32 0.69 0.448 disease
CCL24 6369 Drug Allergy C0013182 Pathologic Function 0.3 0.69 0.448 phenotype
CCL24 6369 Allergic Reaction C1527304 Pathologic Function 0.3 0.69 0.448 phenotype
CCL24 6369 Lobar Pneumonia C0032300 Disease or Syndrome 0.3 0.69 0.448 disease
CCL24 6369 Hypersensitivity C0020517 Pathologic Function 0.3 0.69 0.448 group
CCL24 6369 Experimental Lung Inflammation C0887898 Experimental Model of Disease 0.3 0.69 0.448 disease
CCL24 6369 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.3 0.69 0.448 disease
CCL24 6369 Major Depressive Disorder C1269683 Mental or Behavioral Dysfunction 0.31 0.69 0.448 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types