BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

AltitudeomicsDB
Protein Official symbol BNIP3
Aliases BNIP3 NIP3
Chromosomal Location 10
Length 259
Uniprot ID Q12983
EC number None
Protein family Information(Pfam) PF06553;
PDB id 2J5D;2KA1;2KA2;
InterPro ID IPR010548;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
BNIP3 RHEB 0.975
BNIP3 GABARAPL1 0.943
BNIP3 BCL2L1 0.933
BNIP3 GABARAP 0.929
BNIP3 GABARAPL2 0.924
GABARAP GABARAPL2 0.909
GABARAPL1 GABARAPL2 0.905
GABARAP GABARAPL1 0.903
Gene Ontology Semantic Similarity
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# 664 (BNIP3) 11337 (GABARAP) 23710 (GABARAPL1) 6009 (RHEB) 598 (BCL2L1) 11345 (GABARAPL2)
664 (BNIP3) 1.00 0.74 0.74 0.56 0.89 0.73
11337 (GABARAP) 0.74 1.00 0.97 0.52 0.71 0.92
23710 (GABARAPL1) 0.74 0.97 1.00 0.54 0.71 0.90
6009 (RHEB) 0.56 0.52 0.54 1.00 0.55 0.56
598 (BCL2L1) 0.89 0.71 0.71 0.55 1.00 0.70
11345 (GABARAPL2) 0.73 0.92 0.90 0.56 0.70 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
BNIP3 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 13 RT-qPCR Western US C57BL/6 mice 4.3 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
BNIP3 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 30.6 RT-qPCR Western US C57BL/6 mice 4.3 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
HIF1A 3091 BNIP3 664 Unknown 18320073 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT000305 hsa-miR-145-5p Homo sapiens BNIP3 664 Homo sapiens Microarray//qRT-PCR Functional MTI (Weak) 22815788
MIRT000305 hsa-miR-145-5p Homo sapiens BNIP3 664 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 20332243
MIRT004753 hsa-miR-221-3p Homo sapiens BNIP3 664 Homo sapiens Luciferase reporter assay//Microarray//qRT-PCR//Western blot Functional MTI 20018759
MIRT437693 hsa-miR-27a-3p Homo sapiens BNIP3 664 Homo sapiens Microarray//qRT-PCR Functional MTI (Weak) 22815788
MIRT437701 hsa-miR-27b-3p Homo sapiens BNIP3 664 Homo sapiens Microarray//qRT-PCR Functional MTI (Weak) 22815788
MIRT437785 hsa-miR-210-3p Homo sapiens BNIP3 664 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 23688833
MIRT733973 hsa-miR-34a-5p Homo sapiens BNIP3 664 Homo sapiens PCR array Functional MTI (Weak) 28097098
MIRT734397 hsa-miR-103a-3p Homo sapiens BNIP3 664 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26000071
Gene Ontology
ID GO ID GO Term GO Type
664 GO:0006915 apoptotic process GOTERM_BP_DIRECT
664 GO:0008626 granzyme-mediated apoptotic signaling pathway GOTERM_BP_DIRECT
664 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
664 GO:0005741 mitochondrial outer membrane GOTERM_CC_DIRECT
664 GO:0010637 negative regulation of mitochondrial fusion GOTERM_BP_DIRECT
664 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
664 GO:0043653 mitochondrial fragmentation involved in apoptotic process GOTERM_BP_DIRECT
664 GO:0050873 brown fat cell differentiation GOTERM_BP_DIRECT
664 GO:0051402 neuron apoptotic process GOTERM_BP_DIRECT
664 GO:0071279 cellular response to cobalt ion GOTERM_BP_DIRECT
664 GO:0072593 reactive oxygen species metabolic process GOTERM_BP_DIRECT
664 GO:0090200 positive regulation of release of cytochrome c from mitochondria GOTERM_BP_DIRECT
664 GO:0046982 thyroid hormone receptor binding GOTERM_MF_DIRECT
664 GO:0031307 integral component of mitochondrial outer membrane GOTERM_CC_DIRECT
664 GO:0008219 cell death GOTERM_BP_DIRECT
664 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
664 GO:0043068 positive regulation of programmed cell death GOTERM_BP_DIRECT
664 GO:0010508 positive regulation of autophagy GOTERM_BP_DIRECT
664 GO:0010666 positive regulation of cardiac muscle cell apoptotic process GOTERM_BP_DIRECT
664 GO:0043243 positive regulation of protein complex disassembly GOTERM_BP_DIRECT
664 GO:2000378 negative regulation of reactive oxygen species metabolic process GOTERM_BP_DIRECT
664 GO:0035694 mitochondrial protein catabolic process GOTERM_BP_DIRECT
664 GO:0045837 negative regulation of membrane potential GOTERM_BP_DIRECT
664 GO:0060548 negative regulation of cell death GOTERM_BP_DIRECT
664 GO:0005515 protein binding GOTERM_MF_DIRECT
664 GO:0005740 mitochondrial envelope GOTERM_CC_DIRECT
664 GO:0014069 postsynaptic density GOTERM_CC_DIRECT
664 GO:0048102 autophagic cell death GOTERM_BP_DIRECT
664 GO:0055093 response to hyperoxia GOTERM_BP_DIRECT
664 GO:0071260 cellular response to mechanical stimulus GOTERM_BP_DIRECT
664 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
664 GO:0051607 defense response to virus GOTERM_BP_DIRECT
664 GO:0070301 cellular response to hydrogen peroxide GOTERM_BP_DIRECT
664 GO:0051020 mitogen-activated protein kinase binding GOTERM_MF_DIRECT
664 GO:0046902 regulation of mitochondrial membrane permeability GOTERM_BP_DIRECT
664 GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia GOTERM_BP_DIRECT
664 GO:0030425 dendrite GOTERM_CC_DIRECT
664 GO:0090141 positive regulation of mitochondrial fission GOTERM_BP_DIRECT
664 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
664 GO:0000422 mitophagy GOTERM_BP_DIRECT
664 GO:0016239 positive regulation of macroautophagy GOTERM_BP_DIRECT
664 GO:0005634 nucleus GOTERM_CC_DIRECT
664 GO:0005635 nuclear envelope GOTERM_CC_DIRECT
664 GO:0031966 mitochondrial membrane GOTERM_CC_DIRECT
664 GO:0097345 mitochondrial outer membrane permeabilization GOTERM_BP_DIRECT
664 GO:0005737 cytoplasm GOTERM_CC_DIRECT
664 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
664 GO:1901998 toxin transport GOTERM_BP_DIRECT
664 GO:0042802 ATPase coupled ion transmembrane transporter activity GOTERM_MF_DIRECT
664 GO:0005739 mitochondrion GOTERM_CC_DIRECT
664 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
664 GO:1903715 regulation of aerobic respiration GOTERM_BP_DIRECT
664 GO:0071456 cellular response to hypoxia GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
664 hsa04068 FoxO signaling pathway
664 hsa05134 Legionellosis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
BNIP3 664 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.32 0.569 0.621 disease
BNIP3 664 Prostatic Neoplasms C0033578 Neoplastic Process 0.31 0.569 0.621 group
BNIP3 664 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.569 0.621 disease
BNIP3 664 Multiple Myeloma C0026764 Neoplastic Process 0.32 0.569 0.621 disease
BNIP3 664 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.31 0.569 0.621 disease
BNIP3 664 Manganese Poisoning C0677050 Injury or Poisoning 0.3 0.569 0.621 disease
BNIP3 664 Stomach Neoplasms C0038356 Neoplastic Process 0.3 0.569 0.621 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types