BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

AltitudeomicsDB
Protein Official symbol BNIP3L
Aliases BNIP3L BNIP3A BNIP3H NIX
Chromosomal Location  8
Length 219
Uniprot ID O60238
EC number None
Protein family Information(Pfam) PF06553;
PDB id None
InterPro ID IPR010548;
dbSNP None

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
STEAP3 BNIP3L 0.995
TP53 CREBBP 0.983
BNIP3L TP53 0.943
STEAP3 TP53 0.938
BNIP3L GABARAPL2 0.938
BNIP3L GABARAP 0.934
BNIP3L GABARAPL1 0.933
GABARAP GABARAPL2 0.909
GABARAPL1 GABARAPL2 0.905
BNIP3L CREBBP 0.903
GABARAP GABARAPL1 0.903
STEAP3 CREBBP 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 55240 (STEAP3) 7157 (TP53) 665 (BNIP3L) 11337 (GABARAP) 23710 (GABARAPL1) 1387 (CREBBP) 11345 (GABARAPL2)
55240 (STEAP3) 1.00 0.48 0.60 0.55 0.57 0.43 0.58
7157 (TP53) 0.48 1.00 0.56 0.54 0.55 0.70 0.56
665 (BNIP3L) 0.60 0.56 1.00 0.76 0.75 0.52 0.74
11337 (GABARAP) 0.55 0.54 0.76 1.00 0.97 0.49 0.92
23710 (GABARAPL1) 0.57 0.55 0.75 0.97 1.00 0.51 0.90
1387 (CREBBP) 0.43 0.70 0.52 0.49 0.51 1.00 0.51
11345 (GABARAPL2) 0.58 0.56 0.74 0.92 0.90 0.51 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
BNIP3L Mice Blood 8% Oxygen 7600 m 24 hours upregulated 34.1 RT-qPCR Western US C57BL/6 mice 3 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
BNIP3L Mice Blood 8% Oxygen 7600 m 24 hours upregulated 48 RT-qPCR Western US C57BL/6 mice 3 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
JUND 3727 BNIP3L 665 distal 22955619 TRANSFAC
TAL1 6886 BNIP3L 665 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT003359 hsa-miR-221-3p Homo sapiens BNIP3L 665 Homo sapiens Reporter assay;Western blot;qRT-PCR;Microarray Functional MTI 20018759
MIRT052099 hsa-let-7b-5p Homo sapiens BNIP3L 665 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052472 hsa-let-7a-5p Homo sapiens BNIP3L 665 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT054568 hsa-miR-137 Homo sapiens BNIP3L 665 Homo sapiens Immunofluorescence//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24573672
MIRT438872 hsa-miR-30d-5p Homo sapiens BNIP3L 665 Homo sapiens Luciferase reporter assay Functional MTI 23274497
MIRT660170 hsa-miR-7109-3p Homo sapiens BNIP3L 665 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660167 hsa-miR-4778-3p Homo sapiens BNIP3L 665 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660166 hsa-miR-2682-3p Homo sapiens BNIP3L 665 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660168 hsa-miR-877-3p Homo sapiens BNIP3L 665 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660165 hsa-miR-6781-3p Homo sapiens BNIP3L 665 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660169 hsa-miR-6877-3p Homo sapiens BNIP3L 665 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660171 hsa-miR-6819-3p Homo sapiens BNIP3L 665 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT734912 hsa-miR-30a-5p Homo sapiens BNIP3L 665 Homo sapiens qRT-PCR Functional MTI (Weak) 26472042
Gene Ontology
ID GO ID GO Term GO Type
665 GO:0042981 regulation of apoptotic process GOTERM_BP_DIRECT
665 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
665 GO:0097345 mitochondrial outer membrane permeabilization GOTERM_BP_DIRECT
665 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
665 GO:0005515 protein binding GOTERM_MF_DIRECT
665 GO:0071456 cellular response to hypoxia GOTERM_BP_DIRECT
665 GO:0042802 ATPase activity GOTERM_MF_DIRECT
665 GO:0005741 mitochondrial outer membrane GOTERM_CC_DIRECT
665 GO:0005829 cytosol GOTERM_CC_DIRECT
665 GO:0046982 retinoid X receptor binding GOTERM_MF_DIRECT
665 GO:0060548 negative regulation of cell death GOTERM_BP_DIRECT
665 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
665 GO:0031224 intrinsic component of membrane GOTERM_CC_DIRECT
665 GO:1903214 regulation of protein targeting to mitochondrion GOTERM_BP_DIRECT
665 GO:0035694 mitochondrial protein catabolic process GOTERM_BP_DIRECT
665 GO:0016239 positive regulation of macroautophagy GOTERM_BP_DIRECT
665 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
665 GO:0051607 defense response to virus GOTERM_BP_DIRECT
665 GO:0005635 nuclear envelope GOTERM_CC_DIRECT
665 GO:0005521 insulin-like growth factor binding GOTERM_MF_DIRECT
665 GO:1903146 regulation of mitophagy GOTERM_BP_DIRECT
665 GO:0005739 mitochondrion GOTERM_CC_DIRECT
665 GO:0005740 mitochondrial envelope GOTERM_CC_DIRECT
665 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types