Aurora kinase C

AltitudeomicsDB
Protein Official symbol AURKC
Aliases AURKC AIE2 AIK3 AIRK3 ARK3 STK13
Chromosomal Location  19
Length 309
Uniprot ID Q9UQB9
EC number 2.7.11.1
Protein family Information(Pfam) PF00069;
PDB id 6GR8;6GR9;
InterPro ID IPR030616;IPR030613;IPR011009;IPR000719;IPR017441;IPR008271;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
INCENP CDCA8 0.999
CDCA8 AURKB 0.999
INCENP AURKB 0.999
CDCA8 BIRC5 0.999
INCENP AURKC 0.998
AURKB BIRC5 0.998
INCENP BIRC5 0.992
AURKC BIRC5 0.952
CDCA8 AURKC 0.952
HIST2H3PS2 AURKC 0.939
HIST2H3PS2 AURKB 0.93
AURKB AURKC 0.929
Gene Ontology Semantic Similarity
Download Tab separated file
# 3619 (INCENP) 55143 (CDCA8) 9212 (AURKB) 6795 (AURKC) 332 (BIRC5)
3619 (INCENP) 1.00 1.00 1.00 1.00 1.00
55143 (CDCA8) 1.00 1.00 1.00 1.00 1.00
9212 (AURKB) 1.00 1.00 1.00 0.94 0.61
6795 (AURKC) 1.00 1.00 0.94 1.00 0.58
332 (BIRC5) 1.00 1.00 0.61 0.58 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
AURKC Human Blood - 3650 m 48 hours downregulated 0.695 Microarray Himalayas Indians 1 HAPE Pateints Vs Normal http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
6795 GO:0008608 attachment of spindle microtubules to kinetochore GOTERM_BP_DIRECT
6795 GO:0048599 oocyte development GOTERM_BP_DIRECT
6795 GO:0000780 condensed nuclear chromosome GOTERM_CC_DIRECT
6795 GO:0051255 spindle midzone assembly GOTERM_BP_DIRECT
6795 GO:0035404 histone-serine phosphorylation GOTERM_BP_DIRECT
6795 GO:0051321 meiotic cell cycle GOTERM_BP_DIRECT
6795 GO:0032467 positive regulation of cytokinesis GOTERM_BP_DIRECT
6795 centromericregion None GOTERM_CC_DIRECT
6795 GO:0016570 histone modification GOTERM_BP_DIRECT
6795 GO:0051256 mitotic spindle midzone assembly GOTERM_BP_DIRECT
6795 GO:0035174 phosphatidylinositol binding GOTERM_MF_DIRECT
6795 GO:0006468 protein phosphorylation GOTERM_BP_DIRECT
6795 GO:0004674 protein serine/threonine kinase activity GOTERM_MF_DIRECT
6795 GO:0005524 ATP binding GOTERM_MF_DIRECT
6795 GO:0004672 protein kinase activity GOTERM_MF_DIRECT
6795 GO:0004712 MAP kinase kinase activity GOTERM_MF_DIRECT
6795 GO:0000793 condensed chromosome GOTERM_CC_DIRECT
6795 GO:0000910 cytokinesis GOTERM_BP_DIRECT
6795 GO:0007283 spermatogenesis GOTERM_BP_DIRECT
6795 GO:0005876 spindle microtubule GOTERM_CC_DIRECT
6795 GO:0030496 midbody GOTERM_CC_DIRECT
6795 GO:0032133 chromosome passenger complex GOTERM_CC_DIRECT
6795 GO:0051233 spindle midzone GOTERM_CC_DIRECT
6795 GO:0031616 spindle pole centrosome GOTERM_CC_DIRECT
6795 GO:0005737 cytoplasm GOTERM_CC_DIRECT
6795 GO:0005819 spindle GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
AURKC 6795 Subfertility, Male C0848676 Sign or Symptom 0.3 0.72 0.276 phenotype
AURKC 6795 Male sterility C0917731 Finding 0.3 0.72 0.276 phenotype
AURKC 6795 Male infertility C0021364 Disease or Syndrome 0.42 0.72 0.276 disease
AURKC 6795 Male Infertility with Large-Headed, Multiflagellar, Polyploid Spermatozoa C0403812 Disease or Syndrome 0.6 0.72 0.276 disease
AURKC 6795 Adenocarcinoma of lung (disorder) C0152013 Neoplastic Process 0.3 0.72 0.276 disease
AURKC 6795 Squamous cell carcinoma of lung C0149782 Neoplastic Process 0.3 0.72 0.276 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
AURKC 6795 AMG-900 AMG-900 CHEMBL2140408 inhibitor
AURKC 6795 AMG900 AMG-900 CHEMBL2140408 inhibitor
AURKC 6795 AMG900 AMG-900 CHEMBL2140408 inhibitor
AURKC 6795 AMG900 AMG-900 CHEMBL2140408 None
AURKC 6795 AMG-900 AMG-900 CHEMBL2140408 inhibitor
AURKC 6795 BI847325 None None inhibitor
AURKC 6795 Cenisertib CENISERTIB CHEMBL1614709 inhibitor
AURKC 6795 COMPOUND 38 [PMID: 20817473] None None inhibitor
AURKC 6795 CYC-116 CYC-116 CHEMBL482967 inhibitor
AURKC 6795 CYC116 CYC-116 CHEMBL482967 inhibitor
AURKC 6795 DANUSERTIB DANUSERTIB CHEMBL402548 inhibitor
AURKC 6795 DANUSERTIB DANUSERTIB CHEMBL402548 inhibitor
AURKC 6795 DANUSERTIB DANUSERTIB CHEMBL402548 inhibitor
AURKC 6795 GSK1070916 GSK-1070916 CHEMBL1090479 inhibitor
AURKC 6795 GSK1070916 GSK-1070916 CHEMBL1090479 inhibitor
AURKC 6795 GSK1070916 GSK-1070916 CHEMBL1090479 inhibitor
AURKC 6795 GSK-1070916 GSK-1070916 CHEMBL1090479 inhibitor
AURKC 6795 GSK1070916 GSK-1070916 CHEMBL1090479 inhibitor
AURKC 6795 ILORASERTIB ILORASERTIB CHEMBL1980297 inhibitor
AURKC 6795 MK-6592 MK-6592 CHEMBL3545378 inhibitor
AURKC 6795 MK-5108 MK-5108 CHEMBL3182444 inhibitor
AURKC 6795 None None None None
AURKC 6795 R763 CENISERTIB CHEMBL1614709 None
AURKC 6795 SNS-314 SNS-314 CHEMBL482767 inhibitor
AURKC 6795 SNS-314 SNS-314 CHEMBL482767 inhibitor
AURKC 6795 SNS-314 SNS-314 CHEMBL482767 inhibitor
AURKC 6795 SNS-314 SNS-314 CHEMBL482767 inhibitor
AURKC 6795 SU6656 CHEMBL605003 CHEMBL605003 inhibitor
AURKC 6795 TOZASERTIB TOZASERTIB CHEMBL572878 None
AURKC 6795 TOZASERTIB TOZASERTIB CHEMBL572878 inhibitor
AURKC 6795 TOZASERTIB TOZASERTIB CHEMBL572878 inhibitor
AURKC 6795 TOZASERTIB TOZASERTIB CHEMBL572878 inhibitor
AURKC 6795 TTP-607 TTP-607 CHEMBL3545327 inhibitor