Peroxiredoxin-2

AltitudeomicsDB
Protein Official symbol PRDX2
Aliases PRDX2 NKEFB TDPX1
Chromosomal Location  19
Length 198
Uniprot ID P32119
EC number 1.11.1.24
Protein family Information(Pfam) PF10417;PF00578;
PDB id 1QMV;5B8A;5B8B;5IJT;
InterPro ID IPR000866;IPR024706;IPR019479;IPR036249;IPR013766;
dbSNP rs34012472

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CDK5 CDK5R1 0.992
TXN PRDX2 0.981
CDK5 PRDX2 0.929
CDK5R1 PRDX2 0.904
Gene Ontology Semantic Similarity
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# 1020 (CDK5) 7295 (TXN) 8851 (CDK5R1) 7001 (PRDX2)
1020 (CDK5) 1.00 0.42 0.70 0.42
7295 (TXN) 0.42 1.00 0.48 0.57
8851 (CDK5R1) 0.70 0.48 1.00 0.47
7001 (PRDX2) 0.42 0.57 0.47 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PRDX2 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
PRDX2 Human Skeletal muscle - 4559 m 9 day downregulated -1.62 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
PRDX2 Rat Plasma - 7620 m 24 hours downregulated 1.42 2-DE Northern indo-australian plate Sprague-dawley rats 1 Male SD rats weighing 220g 24842778
PRDX2 Rat Plasma - 7620 m 6 hours upregulated 0.77 2-DE Northern indo-australian plate Sprague-dawley rats 1 Male SD rats weighing 220g 24842778
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
SMARCA4 6597 PRDX2 7001 proximal_filtered 22955619 TRANSFAC
SRF 6722 PRDX2 7001 proximal_filtered 22955619 TRANSFAC
JUND 3727 PRDX2 7001 proximal_filtered 22955619 TRANSFAC
EP300 2033 PRDX2 7001 proximal_filtered 22955619 TRANSFAC
SMARCB1 6598 PRDX2 7001 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023992 hsa-miR-1-3p Homo sapiens PRDX2 7001 Homo sapiens Proteomics;Microarray Functional MTI (Weak) 18668037
MIRT039753 hsa-miR-615-3p Homo sapiens PRDX2 7001 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042800 hsa-miR-339-5p Homo sapiens PRDX2 7001 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046023 hsa-miR-125b-5p Homo sapiens PRDX2 7001 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT047661 hsa-miR-10a-5p Homo sapiens PRDX2 7001 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT732736 hsa-miR-205-5p Homo sapiens PRDX2 7001 Homo sapiens 2-D Gel Electrophoresis (2DGE)//qRT-PCR//Western blot Functional MTI 26633009
MIRT732737 hsa-miR-153-3p Homo sapiens PRDX2 7001 Homo sapiens 2-D Gel Electrophoresis (2DGE)//qRT-PCR//Western blot Functional MTI 26633009
Gene Ontology
ID GO ID GO Term GO Type
7001 GO:0006979 response to oxidative stress GOTERM_BP_DIRECT
7001 GO:0034599 cellular response to oxidative stress GOTERM_BP_DIRECT
7001 GO:0005737 cytoplasm GOTERM_CC_DIRECT
7001 GO:0045454 cell redox homeostasis GOTERM_BP_DIRECT
7001 GO:0000302 response to reactive oxygen species GOTERM_BP_DIRECT
7001 GO:0019430 removal of superoxide radicals GOTERM_BP_DIRECT
7001 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
7001 GO:0005829 cytosol GOTERM_CC_DIRECT
7001 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
7001 GO:0008379 galactosyltransferase activity GOTERM_MF_DIRECT
7001 GO:0042744 hydrogen peroxide catabolic process GOTERM_BP_DIRECT
7001 GO:0005623 cell GOTERM_CC_DIRECT
7001 GO:0042981 regulation of apoptotic process GOTERM_BP_DIRECT
7001 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
7001 GO:0016209 antioxidant activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PRDX2 7001 Prostatic Neoplasms C0033578 Neoplastic Process 0.31 0.535 0.759 group
PRDX2 7001 Trisomy 21, Meiotic Nondisjunction C0432417 Disease or Syndrome 0.3 0.535 0.759 disease
PRDX2 7001 Pulmonary Fibrosis - from Asbestos Exposure C2930617 Disease or Syndrome 0.3 0.535 0.759 disease
PRDX2 7001 Mammary Neoplasms, Experimental C0024668 Experimental Model of Disease; Neoplastic Process 0.3 0.535 0.759 group
PRDX2 7001 Keloid C0022548 Acquired Abnormality 0.3 0.535 0.759 phenotype
PRDX2 7001 Carcinomatosis C0205699 Neoplastic Process 0.3 0.535 0.759 phenotype
PRDX2 7001 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.34 0.535 0.759 disease
PRDX2 7001 Esophageal Neoplasms C0014859 Neoplastic Process 0.3 0.535 0.759 group
PRDX2 7001 Leukemia, Monocytic, Chronic C0023466 Neoplastic Process 0.3 0.535 0.759 disease
PRDX2 7001 Neoplasm Invasiveness C0027626 Pathologic Function 0.3 0.535 0.759 phenotype
PRDX2 7001 Mammary Carcinoma, Animal C1257925 Neoplastic Process 0.3 0.535 0.759 disease
PRDX2 7001 Osteosarcoma C0029463 Neoplastic Process 0.31 0.535 0.759 disease
PRDX2 7001 Undifferentiated carcinoma C0205698 Neoplastic Process 0.3 0.535 0.759 phenotype
PRDX2 7001 Down Syndrome C0013080 Disease or Syndrome 0.33 0.535 0.759 disease
PRDX2 7001 melanoma C0025202 Neoplastic Process 0.32 0.535 0.759 disease
PRDX2 7001 Carcinoma C0007097 Neoplastic Process 0.3 0.535 0.759 group
PRDX2 7001 Down Syndrome, Partial Trisomy 21 C0432416 Disease or Syndrome 0.3 0.535 0.759 disease
PRDX2 7001 Malignant neoplasm of esophagus C0546837 Neoplastic Process 0.3 0.535 0.759 disease
PRDX2 7001 Myeloid Leukemia C0023470 Neoplastic Process 0.31 0.535 0.759 disease
PRDX2 7001 Animal Mammary Neoplasms C0024667 Neoplastic Process 0.3 0.535 0.759 group
PRDX2 7001 Liver carcinoma C2239176 Neoplastic Process 0.34 0.535 0.759 disease
PRDX2 7001 Asbestosis C0003949 Disease or Syndrome 0.3 0.535 0.759 disease
PRDX2 7001 Anaplastic carcinoma C0205696 Neoplastic Process 0.3 0.535 0.759 disease
PRDX2 7001 Carcinoma, Spindle-Cell C0205697 Neoplastic Process 0.3 0.535 0.759 disease
PRDX2 7001 Trisomy 21, Mitotic Nondisjunction C0751081 Disease or Syndrome 0.3 0.535 0.759 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types